<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXU3</accession>
    <name>A0A183GXU3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS53</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01000012">
        <property type="protein sequence ID" value="VDO24343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXU3"/>
    <dbReference type="STRING" id="387005.A0A183GXU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000005201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000005201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000005201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="230"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO24343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000005201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="785" mass="89643" checksum="70D6D19ADE4D564A" modified="2016-09-07" version="1">MNGDFSFTMDVGEIMRTVDVEADVPDFNSLMLNRTSLNALAKAGFTKPSPVQARAIPFGMLGFDLLVQAKSGTGKTMVFALLAVENLNAQVGCSQVLIVAPTREIASQIVSYIRMLAPPVIHVGMFVGGNEKGIAEDIQKLKKSIHIVVGTTGRLCHLVRINVLRLSYIRLFILDEADKLMEDNFQKEINYLFSALPPEKQVAVFSATYPYQLDATLTHYMRDVHLVRIDTDAQLLGVKQYVIVARNETRKMNILLRLLLRLRYGQCIIFQARFDVVCISGNMPQTERTKAMRRLKNCMVKLLVSTDLTARGIDAPGVNVVINYGSPLVLATYLHRIGRAGRFGTHGAAFTILNSDKELKLFSDFAVEGKLRVKLLQVREDWPSNLIYDDEFFSNSEDFHPYMMRNWRGQQDHNDEEDEVYEFMKVGSNSLPEFEEALKLYKDKIALHQKSKKHIYSNQDFYDIFGSMKNNEIPEMLLKKLIALKIRSPYDLDLTRKNTLMTLRMETKNKNSEDISALERSCHEKSFYLLNKEANFTMNIDINMVRHYVPYRGSKENIYEANPTSSATNYVDISNPKELEFVNFDRLLLENLPKYKPDSESPADRLDEKYVKKSSLVGSSDLQELNAGLDESVEWKKKNAKYEACKELRTKLIKIKSRFNYELVLGMNKIRECITTTGEPDIRSVATQTEAEEKLTATRSAQTDGLSFYANSNFVHSNVLCILEIIGRLGIFEINVYMIMTQTLDYSFGHSRFLNCEAVESGEQLFQHFRSGIIENCKLRLNRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYF3</accession>
    <name>A0A183GYF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS263</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000074">
        <property type="protein sequence ID" value="VDO25177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000026201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000026201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000026201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000026201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10877" checksum="8AF89715DDE0199C" modified="2016-09-07" version="1">MEYKEIDVIENSDLFNDMKLKYNVRTVPQIFVNDENGNYMYHIAGCDKLINFEKGGKLDDILNNSKDYIDVTAYIGSNYECEEYVIPPDDNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYG6</accession>
    <name>A0A183GYG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS276</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000080">
        <property type="protein sequence ID" value="VDO25220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYG6"/>
    <dbReference type="WBParaSite" id="OFLC_0000027501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000027501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000027501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048413">
        <property type="entry name" value="Htt_C-HEAT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO25220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000027501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2414" mass="273591" checksum="006F44667266B67A" modified="2016-09-07" version="1">KELLYSFFINLSFRKDPKYSDEFNRAVKILFEYINHRNSDLRMLSEQTMDSVLRHLVIDMNASRVIFILMSEIRRNGSSRSLVFAFSRLLDAVKYVKINHSRAIGMQLISVLPKILSRPEEIVQSALERYLPPVFTFFGSDFETQSNDNVLKLYEAALSNLELPGVTNRAAAVIISQLATYAGVIRRKVFLHFLKVLSEASEQQNRNLLVGTLNSLRLLWPVYLSKNNEYELENLRSIIRDSLRCLFSPHSEIVVASLEFLEKVVSSPLAALDVESFYPQQSKILKSDVKEQDTAVPTNVASCMSSLTASPVNFLSVSLSCAAVDLADNNVQSSFSLPLCADSSSLKMQIESNSEDGTDVIDPLRHLEISDDLIMCSNSSEESLPEITSISSTLIPEDLPLDIFYLIIYVRFICASGPFLAYTTVLLAKRFLLSGQCFKLLADSEVRVSHKILAMSCLSSLALYLPKFADITLQPKGGLGIQTLKDLQLYLNHEDDQLKAIAITVFVNAEKCRFRALGEPFYEFGCSFASFVYDAIRVHRAHCSRSLLIALKSAKKLVYQTGIVHDVAKFACENYRDNYFLLRIAVVEYLASIEWAFACSFATHLPDEIFEIYMYLLADDDQRVRNVAAKHLCLLTENANYISTPNNFALEEPADYLCSDFPKNPLTVGMSPYYDFLQQPFNFIIAGNLSFVLRKMFYILTTSANEKQQAGVAAGLFELLCCFKSRHYAQAWGLESNIDSSRTGLIIALISKCDCCCVDVQTFIQFLNIATHMTAGLYTVSIMKNANKSNNIVSQCPKYFIYEQLILLQLRVINLYYSLIIDHRQQYSFSRSSPLSPVRKAFPVSTNNVASWEQRMAAISTFTGISVKMSRNTSFLQSSSLIHFADSLKGGYFNYMNTLAFDASERFTALLISALNCLACTLEVMRLPQVADILEEILLYCQTVIKFVPGESIRVAMQLFKVLFGSNVANLSPDALRDLKLSHVSQPKDLFDICMLRSANFFTEFIVNTGRVDYGEAQLIREVISHVTMFEPFVSLAILLYQSTNSLDVQCSVLDLLCVLVRGGINYSMLDPETRLLNFVIEQKLLNSIFNYFLSLSHTESRGQVIMGMDRIHSFVELLIKACNARPYLTPCEFAPLSTLNCLQIVVVNCIGMHLSFDVTLLKMLQMIDQLATVCPTRVLQLWILAVVGSHINGDAQSWTKTSLSLFESLQQLHPKNWDLTTAFNAVILLRLCYTAITQPMDSFFKKMISILEDDLHCFSRLVVILPYLFIFLCVLKEDSTFTRIEQICDHAVEKIGRLLMILLGQCLEALQRLTSLDSINEENNENLVIWYLLILSHAVRSGNMESITNTFDAHFSMDFVDLQNLSMFYPRTYAQLFAFVNAAGFHRHRHLFYSSSSKQLGDLCMMTQCGAMDPDGAGDIARLFDFCSPDILLTIVVRGWLACHMSDLDSKVQNTLLENIINLSKNCCSYAVDLDVIELIAFTDVPETSVAIEFLKNKLGESRVLDWLIALFCDQSKNVAFKALLIHFMTSEQYSTDFFFEKTPKLDTKKQNLRFGDPSQFTPGIFADVLQQIIDRKSQAEFICIMLCNVEGRHAEMLLRNAYKCKRYDVLSSFIDMLDQFKIAKECSGELCDELSSSSPLKIEALSASFVSLAFDPSINSSLQLFVQSRIANKPESITYKKASDWVTENSLFDHWIQRYVDSLAVQNGSKTSEAANAIAFGITRRSFLATIDQAQNSKKVVEQQLCLAVSVARLIQCIFEQCNMLPYSGLQKSGDHFWNMKVIDRSGKKDFDIAFFSDAIRTAFNVTQKIQEIFRKKRLKIRLYSHLERLAKAVSRLPFLNDISCIPRSAILCGWKPEPEIHRASISIPTVNIHYLGNVDILQDFVWRILWAGWNRRSNFDNFSMSLFGVISSTPSGSELANANVNMTEQLMASTVAIEGLTNLLLETLLYPERGDPVTGKFIVKPRDVSSDFLSTSYGQRLTMLQAKLLGVAAVDSIHKKNLEILNDRGKKYRPGQFSVFTSWNMAGVLDQERDLYKDIMQINNQPKERLPSSDSSYLLNSGHDTTYESCLRMLFDTYSHWFRAGIDAVPLPLLSATVKSMSLLSDLFTEMDQYHFVFGHMKTLFSIRSYLDNVDIGNIIYSLLKCVSILGIEDSFMPKVEAQKIVLTWVELGLTSEFTEIRIRTLQGCLFLLQAIGFDELKTVFLFLESFLMDFSQMSGSGLYEYETTLWTVRFSFLDNPSYSSDNSRNAFISMICEKFVAVTTPGWLMNLISVGIEKLIIGSRIYVLTFSRIAVQALENYFYAPQKFLYALRIFIACLYRGLEEGRVQHLCTQPYDPRIHLMEQHAMIFRILAEGTEDDASQLMKVLPYLLIDSLNQSEFINSILKELIHRYTDLPHPRSAAIFRIIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYX4</accession>
    <name>A0A183GYX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS434</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000141">
        <property type="protein sequence ID" value="VDO25782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYX4"/>
    <dbReference type="WBParaSite" id="OFLC_0000043301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000043301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000043301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO25782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000043301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11178" checksum="AF035C45DF97CF99" modified="2016-09-07" version="1">MFINSRREGDGKSSSKLFEDGRGGIKRSCSGRTGGAERARTECCKEDRLPLRANTGSVEGSTKGGSTLSFGDYGLKTTETGRILCKHSEAVRRVISGTMKRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZC7</accession>
    <name>A0A183GZC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Jag_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS587</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000204">
        <property type="protein sequence ID" value="VDO26320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZC7"/>
    <dbReference type="STRING" id="387005.A0A183GZC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000058601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000058601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000058601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000058601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6773" checksum="EE5298BDA2245D89" modified="2016-09-07" version="1">MSLVEAEKVALSILKQVMEEKLTSSNVEIVAITPVKDSKGRLTGKFERLSKERLDTLVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H092</accession>
    <name>A0A183H092_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiolase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS902</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000365">
        <property type="protein sequence ID" value="VDO27503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H092"/>
    <dbReference type="STRING" id="387005.A0A183H092"/>
    <dbReference type="WBParaSite" id="OFLC_0000090101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000090101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000090101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF153">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO27503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000090101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40982" checksum="112BF5900987B98C" modified="2016-09-07" version="1">MSRYLSSINPGSICRIRSLYSISCFSNSTASATSTKTFSKSDRPNIILVDAVRTPFLQSRTTFKNMMAIDLQRAALLALVDRTKISMQEIGHIVCGTVIQEHKTSNVAREAALTAGFSKKIPAHTVTLACISSNVAITDIMNMLATGYCNAGIAGGVELLSDVPIRYNRKARSAMLSLDRAKKLSDKLTAVKDIAANFFSPELPAVAEFTTGETMGHSGDRLAAAFGVSRREQDEFAMRSHVLADRAMKENLLSDVIPVFVPGSKPVLVRKDNGIRVSSMEKLAQLKPAFVKFHGTVTPGNSSFLTDGASASLIMTEDYALKKGYKPKAYLRDFLYVAQDPTDQLLLSPAYAIPKLLDKAKIFYLFELLLCLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0I0</accession>
    <name>A0A183H0I0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000409">
        <property type="protein sequence ID" value="VDO27811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0I0"/>
    <dbReference type="STRING" id="387005.A0A183H0I0"/>
    <dbReference type="WBParaSite" id="OFLC_0000098901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000098901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000098901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000098901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14883" checksum="BB9C35D319B76533" modified="2016-09-07" version="1">MNVFKRGGGATKSGRTTPRKSSGLKSDLKSAFENGITKRISSSSDRSFDYNSNENSSTSRSTLDFSRFEHPLKSISSSSLQVTEDDATIKSVKSVEKSSDTQILPPPLPPRRTKISLLLPHHVSTLSFPMEASHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2H3</accession>
    <name>A0A183H2H3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1683</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="UZAJ01000842">
        <property type="protein sequence ID" value="VDO30429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2H3"/>
    <dbReference type="STRING" id="387005.A0A183H2H3"/>
    <dbReference type="WBParaSite" id="OFLC_0000168201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000168201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000168201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO30429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000168201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28652" checksum="CC6195266E9B4E15" modified="2016-09-07" version="1">MLGSDVNERLSSRGKVMLVENFTDLNDKLGLYLREILEKAIAERNCAKIAVSGGSMPTLIAPLLTRLEDIDWSKVRIFAVDERMVPLNDIESNTGAYMKILPSNISQSFVHYGPVDDTVQCAKNYEEQIRHFIKDTEEGWPIFDLLLLGIGPDGHTCSLFPEHPLLRENVKWIAAIEDSPKPPPRRITLTLPVINHARYVAFISTGRNKGELIRGIINGQNSNFPAAMVKPKSGNISWFMDKEAFDAYDCFTNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2R2</accession>
    <name>A0A183H2R2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS1772</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000898">
        <property type="protein sequence ID" value="VDO30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2R2"/>
    <dbReference type="STRING" id="387005.A0A183H2R2"/>
    <dbReference type="WBParaSite" id="OFLC_0000177101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000177101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000177101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDO30729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000177101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49483" checksum="71D88B1A7DFFE112" modified="2016-09-07" version="1">MREIISLHVGQAGVQIGNACWELFCLEHGIQPNGEVVSESNQAARYDASSLTTFFSETASGHYVPRALLADLEPTVVDVIRTGKYKHLFHPEQMVTGYEDAANNYARGHYSIGGDMIDTVVDRVRRLADNCDGLQGFLLFHSFGGGTGSGFTSLLMECLTSDYEKKSKLEFSIYPAPQISTAVVEPYNSILTTHATLEHSNCSFIMDNEAIYEICHRNLDVERPSYSNLNRLIAQIVSSITTSLRFDGVLNVDLMEFQTNLVPYPRIHFPLVTYAPVISVEKAYHESLSVMDITKACFDTPNQMVKCDPAKGKYMSVCLLYRGDVTPTDVNKTISSVRHHRQIHFVDWCPTGFKIGINYKPPTVVPDGDVAPVPRTLCMLANTTAIAEAWARLDVKFDRMFAKRAFVHWYVGEGMEEGEFTEAREDMAALEKDYEEVLYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H416</accession>
    <name>A0A183H416_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2226</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001236">
        <property type="protein sequence ID" value="VDO32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H416"/>
    <dbReference type="STRING" id="387005.A0A183H416"/>
    <dbReference type="WBParaSite" id="OFLC_0000222501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000222501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000222501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000222501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9778" checksum="CF1C874B2FD9DF0D" modified="2016-09-07" version="1">MWNGDIDVNNLENGYGVYFSAANIQQIAPNPPATMLVLSSHYVKLTHLRKHCYIQKCLCITHGMRVENHLNNANEENQLTETWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H551</accession>
    <name>A0A183H551_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2611</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001533">
        <property type="protein sequence ID" value="VDO33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H551"/>
    <dbReference type="WBParaSite" id="OFLC_0000261001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000261001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000261001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000261001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27040" checksum="A7F2E8586B4992F2" modified="2016-09-07" version="1">MDEENHSNHPRHPILRMLDRHIIYTAECPTHSTEVEEADRPQIIKRFVLNEEHIPVSIKASTCFRSSRSGCVKCFNSSLSFKISILKREPPPNKLENGLPSLPQIAPSHKTKGIGRQSHSFHSCAMRRGERGREVGVLAVVRYSSYLETVSRPGAAIRWRDWFAYVDIQEGMFRRRGDKRVVMTQCSSFPLSRYFGLLRCVNICRPSSLRSYCARPGYRFQDEEGCSFTGHHPCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H554</accession>
    <name>A0A183H554_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2614</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001536">
        <property type="protein sequence ID" value="VDO33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H554"/>
    <dbReference type="STRING" id="387005.A0A183H554"/>
    <dbReference type="WBParaSite" id="OFLC_0000261301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000261301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000261301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000261301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14362" checksum="C88176A124A2E78D" modified="2016-09-07" version="1">MASELSKSATFHNFCDETNVLSPLPSQAPTPNTFASWIQFFLLRKRHSTIGRQIVLRPSVSLYQVCPSRAVVDETKALGSDGESIEVSPCSSDQCANQSDRHVINVKMRQKPTRRWNEWRTARGIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Z9</accession>
    <name>A0A183H5Z9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01001801">
        <property type="protein sequence ID" value="VDO34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Z9"/>
    <dbReference type="STRING" id="387005.A0A183H5Z9"/>
    <dbReference type="WBParaSite" id="OFLC_0000290901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000290901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000290901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF1">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000290901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21036" checksum="DEF20D69094B88CA" modified="2016-09-07" version="1">MTELLSTHFDFSAPSYLSNYFVIDKHKQRQIIGMDIKLAEGYSFVELDPKRHADTIASCWKFSTHGERDQFEAKIRRLPSIGVQSHDGTLVSFTVLDAAGFFNNQFTFAEHRQRGLADRSELRLCQKVISFGLYPMKFVEHENTAVLDRSCRSQWWNTVNDEAGIPVINDHRAVYRRIPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6J3</accession>
    <name>A0A183H6J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001973">
        <property type="protein sequence ID" value="VDO35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6J3"/>
    <dbReference type="STRING" id="387005.A0A183H6J3"/>
    <dbReference type="WBParaSite" id="OFLC_0000310401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000310401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000310401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000310401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19967" checksum="4002ACBACA1A2450" modified="2016-09-07" version="1">MQFVKALAEVKKATGYYIGGIMLSIAFFVLKITNGLCNFVFSMKDECGLDRREHEIMVFLVIMIVYKNRKAANWMHCLANMFLFCKLANIFLFLRADFIAGVIYICICLVHSVFYPEPVCEESESTVIYNNTELYEEIQRNTKITWLIYFYTSWSPDCRHISPVFAELSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6R6</accession>
    <name>A0A183H6R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA_bind_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002049">
        <property type="protein sequence ID" value="VDO35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6R6"/>
    <dbReference type="STRING" id="387005.A0A183H6R6"/>
    <dbReference type="WBParaSite" id="OFLC_0000317701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000317701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000317701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Possible tRNA binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000317701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30658" checksum="9A1684F8EA558837" modified="2016-09-07" version="1">MALSILQLKNDEIVKQCRREVLTREKLGLFLSNSDLRRLSQYARNMIDHHLITDILPILALLYFEERFDEEVGEILFFMYSIIKLSSVQSAILLGIGLQHKTVDVLVTELDLPANQLLALFNKAIRKLSEYLDQICMDAVRQEIDSQEINEHSADVTSMQPVPISLDDELHEAAVEIKRRQDRDRARLKEEIGRELKQYAIKGNEDDWTNALQSTDLKTAKKTGTILSVKSSRITFHWGQCIRKGFSWAYGYFKNRNNLEKFPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H734</accession>
    <name>A0A183H734_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3296</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002165">
        <property type="protein sequence ID" value="VDO36015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H734"/>
    <dbReference type="STRING" id="387005.A0A183H734"/>
    <dbReference type="WBParaSite" id="OFLC_0000329501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000329501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000329501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO36015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000329501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="22282" checksum="A54D97BAEE0E445A" modified="2016-09-07" version="1">MIRRNDCTRRMPYNEKSCYDIRLLQKIIYFFNFLFYRIEFIIFEFQMQISSVAFIGLAIWTYTMKYTMIGSLLYSSRYLQSIILCFVIGLAVFVVASSGCWAISRRKQLLLLLYTVLVLLTMLMELALCIMTYAYIEHLKNNLGTTLFMSVIRDHSERNDISEALHYLHQQVQQHMLIHENHYLLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7R9</accession>
    <name>A0A183H7R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002384">
        <property type="protein sequence ID" value="VDO36846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7R9"/>
    <dbReference type="WBParaSite" id="OFLC_0000353001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000353001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000353001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000353001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7849" checksum="A08A47248B8F8CCE" modified="2016-09-07" version="1">MVLSDSEISPVKIVLSDSEISPVEMVLSDSEISPVEMVLNDSEISPVEIVLSDTARPKANANAMRDFKFIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H863</accession>
    <name>A0A183H863_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002545">
        <property type="protein sequence ID" value="VDO37385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H863"/>
    <dbReference type="STRING" id="387005.A0A183H863"/>
    <dbReference type="WBParaSite" id="OFLC_0000367401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000367401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000367401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000367401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20989" checksum="5D0AD06B58B6BB5B" modified="2016-09-07" version="1">MATPTSNATITEITEVSTMEVGKQQQSRETSPPSPIIVLRSAPGRATWTKRLSKTIQRRSGSFINTLTAFRKNIDQNQSNANSDKLVLPSPLHHKRRASASPIVSLQTPTIKGVSSIFGNEKLSDISVATATATAATAGVVALISSGMQQEDIGEREGNVDSEIYSEEKKKQQQQKQQQKHQQQRKQHQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8H1</accession>
    <name>A0A183H8H1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3782</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002640">
        <property type="protein sequence ID" value="VDO37725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8H1"/>
    <dbReference type="STRING" id="387005.A0A183H8H1"/>
    <dbReference type="WBParaSite" id="OFLC_0000378201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000378201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000378201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF209">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO37725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000378201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51768" checksum="77EEB45C29B34F38" modified="2016-09-07" version="1">MTTTEYAGVRRNSDGGSEYSWRDALPASMISKSELSIWSVLKKCIGKDLTRISIPVVFNEPLSFLQRLAEYMEYAELLEKANKCTDAVERFEYVAAFIVSSLSCNYMRLSKPFNPLWFETYELDRSEKSNYRFIAEQVSHHPPKSALHAESKSYEFDGVVSPRLKFWGTCIEVQPSGTFQLKLLNYSEIYTWKALNVTVHNIVMGQMYMQLANTNFKWNLININWDFFFQEGYLHVQCNTGLECKLSFKNNDNGPSRRSTFFQGYISKQEKILRAIYGNWTAFLATCDITNFEFRYNNWLEIGKQFFQNCSIPKDIPLIQGSKLIWKNHPRPSNSSAVSMYNFTSFTFLLNDPAGITDLLPPTDSRRRPDIRLLEAGQAEAAEKEKERLEIKQRQARALMRYTKEKLPKWFKKVNIISKDQLSWIFTYKYWNREYCDCEDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H989</accession>
    <name>A0A183H989_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4051</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002931">
        <property type="protein sequence ID" value="VDO38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H989"/>
    <dbReference type="STRING" id="387005.A0A183H989"/>
    <dbReference type="WBParaSite" id="OFLC_0000405001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000405001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000405001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000405001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17555" checksum="961BB07D2C7CC454" modified="2016-09-07" version="1">DIKPSNFATGRSDVAYGVRKIFLIDFGLCYHYVDSKDQVKHVRRDMSFKGTLRYAPLGSHRRHPPGRRDDLESWMYQQIEFTKGRLPWKNLDDEQSIMNVKEIARTNDGMQKLLRSCPKKYMEIMKHICKLKYTSKPDYDLIYKVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9H9</accession>
    <name>A0A183H9H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4139</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003031">
        <property type="protein sequence ID" value="VDO39056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9H9"/>
    <dbReference type="STRING" id="387005.A0A183H9H9"/>
    <dbReference type="WBParaSite" id="OFLC_0000414001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000414001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000414001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO39056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000414001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16675" checksum="1DDE27AAE3B88F56" modified="2016-09-07" version="1">WKLLKSTLKQEKDENAPSPLLRPNPRIVISEDGQAANTHPTTKRDKFAPIDYNSGGYVVNCRSSTARNFRSRAIRISFQLVAAYIICWLPYNGLSLYQYVDPQGFFEAHVNKVYCLHSIMVFNAVINPYLYGLFGNFLPQKRTGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Q8</accession>
    <name>A0A183H9Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003115">
        <property type="protein sequence ID" value="VDO39318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0000421901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000421901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000421901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000421901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14073" checksum="B2A9678161013BA5" modified="2016-09-07" version="1">MEASGCSQQLLQNQQCRIHPNMKVTREIQVNGKSIETKYAGEYMYISSEGQAMFINYAPNEESCYNDDFPVHAYQVHTPTIYNGDDCLSKRWAEITQKLDRFAQNNCEKNRWNAIDETDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9U7</accession>
    <name>A0A183H9U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4259</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003158">
        <property type="protein sequence ID" value="VDO39449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9U7"/>
    <dbReference type="STRING" id="387005.A0A183H9U7"/>
    <dbReference type="WBParaSite" id="OFLC_0000425801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000425801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000425801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000425801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15774" checksum="FD562204244BE8B8" modified="2016-09-07" version="1">MANVDGLQCAATSQRTISEYSRRELQEAFSKCDPEGTGATSIKNLKTILRSLGFEPRNDEIRILTAKIEENGKQQKDKVTFEELSDLLSEKLDERNGISEMHAAFELFDCDLKGYITIDDLRRVAEELGETIAEDQLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAP9</accession>
    <name>A0A183HAP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LETM1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4561</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003512">
        <property type="protein sequence ID" value="VDO40332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAP9"/>
    <dbReference type="WBParaSite" id="OFLC_0000456001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000456001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000456001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000456001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17363" checksum="5785BE27EA17BAE3" modified="2016-09-07" version="1">MLIIRNIHLSVFGSKLVPLDLWLKNGEIPQLLVPKLQMIIDNSANNHSSSTANNQPKGLMARYESFLSRRYPKVYAVHKMVTNGCKWCWSDVKIYYRLKKDLRTKTRQLSELKRSELEILLQTKEELLKLAVIVILIPLPFTIYIIALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAX7</accession>
    <name>A0A183HAX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4641</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003626">
        <property type="protein sequence ID" value="VDO40598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAX7"/>
    <dbReference type="STRING" id="387005.A0A183HAX7"/>
    <dbReference type="WBParaSite" id="OFLC_0000463801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000463801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000463801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000463801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7570" checksum="22494C76143075AA" modified="2016-09-07" version="1">MFDKKDCGKISEEELMKILHNKRGEPFDDEEIKAMYKGKPPIENGQVDYKAFAHLITTGAAEELAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB11</accession>
    <name>A0A183HB11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4673</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003666">
        <property type="protein sequence ID" value="VDO40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB11"/>
    <dbReference type="STRING" id="387005.A0A183HB11"/>
    <dbReference type="WBParaSite" id="OFLC_0000467201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000467201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000467201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000467201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19249" checksum="5415838AAF3E0567" modified="2016-09-07" version="1">MAMQQAESLTIRNNQEGDELFTDVVCFGSRSVAALLTLGIDVGVAQLQLASRCELAALLDPSDAMGRDWSILAVKLNLTDQLPEVDSTGQSLSRTDQLLAEWALQCPLTATVGRLCTVLEELGRQDARDALYRTVPLYLFAPLEEQQMIHLTEYGDSGVVSSTQSTTDPRSASTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB20</accession>
    <name>A0A183HB20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4685</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003680">
        <property type="protein sequence ID" value="VDO40729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB20"/>
    <dbReference type="WBParaSite" id="OFLC_0000468101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000468101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000468101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000468101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9589" checksum="E9A7A015FCEA2D08" modified="2016-09-07" version="1">MYPLGGSRRQGKGGELDRDGSLGWSLVTGMTKLNRTGRRASRQCSALHFLPFENQKQKQPLSFKNPLSLILSAPFSIIANFVQILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB75</accession>
    <name>A0A183HB75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4739</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003750">
        <property type="protein sequence ID" value="VDO40907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB75"/>
    <dbReference type="STRING" id="387005.A0A183HB75"/>
    <dbReference type="WBParaSite" id="OFLC_0000473601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000473601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000473601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF296">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000473601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17374" checksum="9846303DA62847F6" modified="2016-09-07" version="1">MEDDADREQQLSKLSKIRDTYRKIAEIASEECSIASKQSHFRPQLFQSLSKLSSFMEGRDFLLDPDVNQLEELILPKWTAVPSILYALSILTTTGYLSAVPMTKLGQFIAIIYGLVGIPLMVLAAVDIGRFLSDIVLGLYQKVISSMTNLKLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBN2</accession>
    <name>A0A183HBN2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS4894</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01003949">
        <property type="protein sequence ID" value="VDO41365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBN2"/>
    <dbReference type="STRING" id="387005.A0A183HBN2"/>
    <dbReference type="WBParaSite" id="OFLC_0000489301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000489301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000489301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="53"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO41365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000489301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40697" checksum="2529C1E45669850B" modified="2016-09-07" version="1">MACFLKENKPFYLNGFPWTARYAKRRDYKQELFHLCTQKSIQPWRLRKTILDLSNPIKLGEGTFGEVFRVNYKSEVVALKVIPIGGTKMINGDKQKSFRDITAELIVSKELSDLKQTEDGYSTQGFIHLMGAVVVKGSYPKSLVIAWEQYDKRMKSENDHPCIFDSSQHFLLLAFEDGGIDLEKYVIANVLQAYSIIYQVLLALSVAEYRLSFEHRDLHCGNILIRNVQSDAVVKTDYNGAEISVCTYGVEVKIIDFTLSRMSKGTSTIFFDLAKDDELFAGENCLQYEIYRAMRMVNKNNWFPFCSMTNVLWLIYLVRYLYDSMDEKSIGSQSERKDFIYHFKDLHRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBP8</accession>
    <name>A0A183HBP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4910</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003971">
        <property type="protein sequence ID" value="VDO41417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBP8"/>
    <dbReference type="WBParaSite" id="OFLC_0000490901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000490901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000490901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000490901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10037" checksum="8CA3750DCCEC1DB6" modified="2016-09-07" version="1">MLLSWLRLAAKRTDIRPLHKRILTDNVLDKLYSMTVISLIGGALCMTSVAMVNIVMYYKVVKPVREADRERLEKDLIEADEAGFSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC30</accession>
    <name>A0A183HC30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trichohyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004134">
        <property type="protein sequence ID" value="VDO41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC30"/>
    <dbReference type="STRING" id="387005.A0A183HC30"/>
    <dbReference type="WBParaSite" id="OFLC_0000504101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000504101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000504101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000504101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41913" checksum="D48E226A1055D3D9" modified="2016-09-07" version="1">MAGTSGKEQKLMTRSFEQKREQRTSGIAGQEKKEEAAGTLAQEKGKAARTPEQKYEKGTTTSEQKQDRPMVISMRKRKREAGSFVQKQVIKIPEQEERTGIVVQKEERTFRTPDQEKKETTGALMLEEKKTIETSTYEQERRTAISYQKQKEVIRTSQQRQDEAIRIPMQKQEGTIRIIKRRQERTYGAPTQMQEDTTTSSVQKQKKTSATPMQKQERASTIPKQRQESAAGIPKQKPESATGTPVQKQGTPVQKQERTIRTPTQKQERTLLQRQEATTRTPTQKQEKATGTSTQKQESTSVQKRERIIETPTQKQGTLVQKQGKTTGTSTQKQERTSMQRQKATTGTPTQKQERTTGTPTQKQERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDU2</accession>
    <name>A0A183HDU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5653</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004969">
        <property type="protein sequence ID" value="VDO43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000565301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000565301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000565301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000565301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16610" checksum="0AA0C134FD6FF765" modified="2016-09-07" version="1">MPTNIHPPTHPSSLSRPFFTPNNHLSPTIIVKLSGSIRNDSIRFDSIRLDPVLSRRQSTIDNDIECFFFLSIVQTDTYTDRPIHAHKRTDTYYKQTDTYTYSDRHMYRQADTYTDRLTYTHRQTDIRKHRRTSSNRQMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFI5</accession>
    <name>A0A183HFI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005833">
        <property type="protein sequence ID" value="VDO45908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFI5"/>
    <dbReference type="WBParaSite" id="OFLC_0000624601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000624601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000624601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000624601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13872" checksum="4E7A6CA23F35A0E5" modified="2016-09-07" version="1">MCKNENLLFGTNVQWRTEICRASDRLLQDYVEIPDHLGKSAKRSTSWNILTSIAGNWEPERCRLINDRMFFNNIKRRFKRLQFPIHLAFLFTTSWTQATLRVANPASLWGPTTLRVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFL5</accession>
    <name>A0A183HFL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005871">
        <property type="protein sequence ID" value="VDO46004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFL5"/>
    <dbReference type="STRING" id="387005.A0A183HFL5"/>
    <dbReference type="WBParaSite" id="OFLC_0000627601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000627601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000627601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000627601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28615" checksum="E02FB10D90BADA16" modified="2016-09-07" version="1">MAGLVTGIVDDSSTTLQELPSVNNDEPEIPKSSETPLSLNKLNNGALEQVQDNKREETERTMILHEEVEKASSGIKREEFSIRSSGSSDSVTVQPDPALDEVIDSLFEASKMVDNARKTADELENHVQDLTTQVINNAHSAGAADITSCMEQLTTGRDIFDGQVTSITHDINDNASALANQNAYEEKRAEEMYLPPMTSAARARAKPVVNGVKTKPKLSQPLYFDIVFVPHHGANPILKDEEAAKAFVTSIRSRQCFIEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFU8</accession>
    <name>A0A183HFU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006001">
        <property type="protein sequence ID" value="VDO46324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFU8"/>
    <dbReference type="STRING" id="387005.A0A183HFU8"/>
    <dbReference type="WBParaSite" id="OFLC_0000635901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000635901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000635901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000635901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19571" checksum="85305D4BC90651B9" modified="2016-09-07" version="1">MAQYSFDKLKNCRDANNRTGYALALGSLHRYVGSLGSGQHLNTSVSILLALAQDATSSLVQSWSLVALSLIADTGGGMFRGYVEPSLNLCLKLLLDTPSANVDVMQCTGKFVSALINTMGPELQLVGAVEGTRTSFLIASIMMLNSSDSLVQAEAISCLQQLHLFTPRHVHLDRLVIRLCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG53</accession>
    <name>A0A183HG53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6463</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006153">
        <property type="protein sequence ID" value="VDO46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG53"/>
    <dbReference type="WBParaSite" id="OFLC_0000646401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000646401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000646401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000646401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11257" checksum="4F7815C34D81D59F" modified="2016-09-07" version="1">MRKAGELKGSKTVTTNAKNDHSQQHKKFLWQLNSKSGALQLSVRLAKLNEVAEKEEDYLALKHDISAEENAEHLSESELSENKENEREDEEDNMFQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHS1</accession>
    <name>A0A183HHS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7032</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007078">
        <property type="protein sequence ID" value="VDO48962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHS1"/>
    <dbReference type="STRING" id="387005.A0A183HHS1"/>
    <dbReference type="WBParaSite" id="OFLC_0000703201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000703201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000703201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000703201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12590" checksum="FF62FB735175B5F2" modified="2016-09-07" version="1">MVLVTESETDEICSLCIWNKQISQLESFLFIRGSKTSKSQDADEAGTAGEQKISSLEIIIRTFLGTLIRMQKGMQCDLVGLGKETVAQLEELKSLLALSKRLYASANEYAAKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHU4</accession>
    <name>A0A183HHU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7054</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007110">
        <property type="protein sequence ID" value="VDO49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHU4"/>
    <dbReference type="WBParaSite" id="OFLC_0000705501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000705501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000705501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000705501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8071" checksum="2315311426E72A9D" modified="2016-09-07" version="1">MRYLGGRRSGALKQESSKISSLALGDIVAAVFVPFFSSSTHTTDDCSFSFIPLIASNNSQFFDDSILQLPKHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI94</accession>
    <name>A0A183HI94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EHD_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7205</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007362">
        <property type="protein sequence ID" value="VDO49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI94"/>
    <dbReference type="STRING" id="387005.A0A183HI94"/>
    <dbReference type="WBParaSite" id="OFLC_0000720501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000720501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000720501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000720501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14042" checksum="4B086CD305395C7A" modified="2016-09-07" version="1">MLSSALARHIRPRKMFSWLGGDSSKKKQQQDEEEGKQRVKEQRNRSRVVRPFSDYRIQPFSSPLQVEIFTFEGVLETVSDGLRKIYKQKLLPLEEYYKFHDFHSPALGKCVYCCFLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI96</accession>
    <name>A0A183HI96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007364">
        <property type="protein sequence ID" value="VDO49819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI96"/>
    <dbReference type="WBParaSite" id="OFLC_0000720701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000720701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000720701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000720701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9142" checksum="BE46095C9303D840" modified="2016-09-07" version="1">MDAAIWGKSTNDSNATERPAAKLEDERLRAHRSCSAASDLLCSEQNECCKLRLAERRQQETRNQRQTGLRVQSPCILIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIT5</accession>
    <name>A0A183HIT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vigilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7393</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007698">
        <property type="protein sequence ID" value="VDO50797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIT5"/>
    <dbReference type="STRING" id="387005.A0A183HIT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000739601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000739601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000739601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22414">
        <property type="entry name" value="KH-I_Vigilin_rpt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO50797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000739601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26798" checksum="272A483FF620CF98" modified="2016-09-07" version="1">ANITTVEVNIPQKIHSRLLGGGRRLILDIQDECGGVHIKFPLEKTTSDKVSIRGPKDDVARAEKMLMALAKDRELSSFEDSVSAKPEFHRFIIGKGGSRIRKIREMYPDVRILFPRDSDTDKDIIHLVGKKEDVTEVKKQLESMITELNENVEAKMEVDPKHHRHFVIRGAAVLREIQDQNGGVIISFPRAGTNDSKVTLKGSKQCVECAKARIEEIVEDLVSLNILLEKDYLKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ48</accession>
    <name>A0A183HJ48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7510</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007892">
        <property type="protein sequence ID" value="VDO51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ48"/>
    <dbReference type="STRING" id="387005.A0A183HJ48"/>
    <dbReference type="WBParaSite" id="OFLC_0000750901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000750901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000750901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000750901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12307" checksum="93833AED6B09C47D" modified="2016-09-07" version="1">MLVGIPPFQGDTITDIYAEMLTGRIHFPKKMDYFIKDFIKMLLQLDPAKRLGNLKGGVADIKIHKWFSDIIWDDVINMKITVIFATFTCNIIYAKFYEFDSFQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ87</accession>
    <name>A0A183HJ87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7548</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007958">
        <property type="protein sequence ID" value="VDO51489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ87"/>
    <dbReference type="STRING" id="387005.A0A183HJ87"/>
    <dbReference type="WBParaSite" id="OFLC_0000754801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000754801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000754801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO51489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000754801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10088" checksum="EDEEB8CABFC01973" modified="2016-09-07" version="1">MGALFLPFAVGFKFSHKQFAVYLESVQQTPIYALTLPIAIIWTEKCVRKSTQKNRQKAMELKGTEAANYYFVCILIHFIFTKLSFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJK4</accession>
    <name>A0A183HJK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7668</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008165">
        <property type="protein sequence ID" value="VDO52119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000766501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000766501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000766501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552559" evidence="1">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000766501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20101" checksum="AE855799AAFD762C" modified="2016-09-07" version="1">MILFLLLFSAKTVSAIGVCTQREMACGSQIRSYPLLRSHETFRRDVESVMEDIPLYDESFTPANIFDFSKAANVTSERICECRNDTSCDSKEENIIKLDEMITLIFCDRIDDIFVRPCRGPRSLIRVIGRIHESGEALTTVVKTLLFCKCERGYQRIHVEPWSDHLYGFIYRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT6</accession>
    <name>A0A183HJT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RR_TM4-6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7747</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008284">
        <property type="protein sequence ID" value="VDO52391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT6"/>
    <dbReference type="STRING" id="387005.A0A183HJT6"/>
    <dbReference type="WBParaSite" id="OFLC_0000774701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000774701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000774701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine Receptor TM 4-6" evidence="2">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO52391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000774701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25892" checksum="1033DA35FE1250A9" modified="2016-09-07" version="1">MTWAQLIFAIVTLSIKASVKVAMFIYLIICTLFRFGYYLMTPDRDDLEVEQAALPMPESADIQYTSPVWPSFQQSHRSGNYDVFGVRLPSTYAQTPTTPMGQPKPEVTNASSPIQQSEAVLKPSTQQDPSMYETQTVSDNACYNQIASPAVSEYGVADYYEPKIAEQISSRSRGSLLNMLARNFKPIEKTTLYLAFFINVILLFHRIRITEDETPAGEMVTYENVNIDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV7</accession>
    <name>A0A183HJV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008326">
        <property type="protein sequence ID" value="VDO52444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV7"/>
    <dbReference type="STRING" id="387005.A0A183HJV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000776801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9198" checksum="E9B4DEB8FD2D1AC1" modified="2016-09-07" version="1">MGWFLGCRTKVSEARRGRKRMKSGTSRLFELLPDPYDISQRRFFRICLFSDVKNAPELRQALVAGSIDAALIKPELVRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK03</accession>
    <name>A0A183HK03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7819</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008412">
        <property type="protein sequence ID" value="VDO52656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK03"/>
    <dbReference type="STRING" id="387005.A0A183HK03"/>
    <dbReference type="WBParaSite" id="OFLC_0000781401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000781401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000781401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO52656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000781401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19679" checksum="A563878396E44633" modified="2016-09-07" version="1">MQDTIETEKQLLEDKTMHLNEEITRKNAMIEELEANLDEHAQLAVSSVSSYTIDDQVLRQLFLSYFTADKDKQPEIAVLLASVLGYSQEDIAKINAANHSSSRGWFSFGSSSKFPQQNISLAEQFVRFLEKESLTTPHFLPVQQSEEKETIRSNVPLNCSRTSSATDLYSILNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKB6</accession>
    <name>A0A183HKB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase_C_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7929</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008611">
        <property type="protein sequence ID" value="VDO53205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKB6"/>
    <dbReference type="STRING" id="387005.A0A183HKB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000792701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000792701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000792701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase XPB/Ssl2 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO53205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000792701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17280" checksum="4558CD0EE42487E6" modified="2016-09-07" version="1">MKLKPDHASRPLWVAPDGHIFLESFSPVYKHAHDFLIAISEPVCRPEFIHEYQLTAYSLYAAVSIGLQTNDIIEYLERLSKSSLPKGIIEFIKICTVSYGKVKLVLKYNRYFIESRHSDVVQTLLKDKVIQQCLVEDKPAIEVPQTVSFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKN0</accession>
    <name>A0A183HKN0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8041</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01008812">
        <property type="protein sequence ID" value="VDO53767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKN0"/>
    <dbReference type="STRING" id="387005.A0A183HKN0"/>
    <dbReference type="WBParaSite" id="OFLC_0000804101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000804101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000804101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO53767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000804101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22909" checksum="79E06295566315E3" modified="2016-09-07" version="1">MQTVDLDEVTSRDIRLKVEETMRMKLDKYKDFISRQMMVIMGQMDKASQIFPYLYLGTEWNACDWQWLENNGIKYIVNVTNEVENFFPARLKYLKIRVSDEASTELLKYWNQTNQFIKEAKEKGSSVLVHCKKGISRSSSTVIAFAMKEYGWALSQAIEHVKNKRGCITPNIGFVEQLRTFEGSLDKFKIYLCLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL63</accession>
    <name>A0A183HL63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spaetzle domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8226</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009139">
        <property type="protein sequence ID" value="VDO54659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL63"/>
    <dbReference type="STRING" id="387005.A0A183HL63"/>
    <dbReference type="WBParaSite" id="OFLC_0000822401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000822401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000822401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000822401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15028" checksum="840B34B14843EEB0" modified="2016-09-07" version="1">KNSRIRFEFTETRYKCDPVCEEYVEVKHKLDFQSSGFRSCCLPIVAQPTKSRLLTPVYKTTPAMKINFIRCQCRIIFVKCKITYPTKNRSELNSSLSARRSLNAQLPAKSSNYKKSYNYYRYSKPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLM3</accession>
    <name>A0A183HLM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dzip-like_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8385</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009431">
        <property type="protein sequence ID" value="VDO55413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLM3"/>
    <dbReference type="STRING" id="387005.A0A183HLM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000838401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000838401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000838401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000838401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15548" checksum="B6412232123BB4A8" modified="2016-09-07" version="1">MACSFEKLVVILFRDRVERLFESNLIEGVCCDPNMPLYGARLVYSRHISHRNLSSLPDTFKPFKLLNRIISYIDDVTGATEIREAHTILKQNEKKLQDAQALRREKRGELDALQIRMKQIHSELDRYSRGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM10</accession>
    <name>A0A183HM10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS8522</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009709">
        <property type="protein sequence ID" value="VDO56096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM10"/>
    <dbReference type="STRING" id="387005.A0A183HM10"/>
    <dbReference type="WBParaSite" id="OFLC_0000852101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000852101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000852101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO56096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000852101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18291" checksum="B765B19572ABC66E" modified="2016-09-07" version="1">MFGRSSDYWFFILPYPIHGVFFREITRVMLPCSHIFLFYYSTCDVQVVSMTIGFETVTKQRKTASSFRDGYLFDIFELSTSMLRKTVNGSRINERELSTVSCLLQLSLNCLSFDFIGSLADETNDDNATVQVPTLWRLGYFLHLFEIKKKLKLFCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMD6</accession>
    <name>A0A183HMD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009953">
        <property type="protein sequence ID" value="VDO56704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMD6"/>
    <dbReference type="STRING" id="387005.A0A183HMD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000864701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000864701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000864701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000864701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27413" checksum="4A03C006A41B48FA" modified="2016-09-07" version="1">MTKPLQSSLCRCVKSKCEPKSFVTKNSFTKSLTEKFIREGRLYVDKNDSIVDTTIGAIIDDSVFICVKCKGLHLGDENILKHLRICLQKDVESPDPEKHFDLMDSKTVIRLTQSHCSPNGRISCPECECKVTSCSIASLRRHLALDHGIFAYYNIPESHRAVGIMEYIPSRCKTTKDTKLDVAARINLELNLTPTGDFKLRQDKRPQSPSLTSGNFFIRFVLGTVQNEFIGSSITKRKVEGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMK3</accession>
    <name>A0A183HMK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8714</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010077">
        <property type="protein sequence ID" value="VDO57019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000871401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000871401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000871401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO57019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000871401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8276" checksum="8FAA5E7CE0764528" modified="2016-09-07" version="1">MPLFGPKKVLIPDCCCRIRWRLMEEPEVDNVRVVVRCRPLSHAEHEQGYQTIVSVDSANNSISVTNPNNDQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN00</accession>
    <name>A0A183HN00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8863</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010375">
        <property type="protein sequence ID" value="VDO57778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN00"/>
    <dbReference type="STRING" id="387005.A0A183HN00"/>
    <dbReference type="WBParaSite" id="OFLC_0000886101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000886101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000886101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="10">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO57778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000886101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16816" checksum="7BEC8FD6DB26906E" modified="2016-09-07" version="1">MDASAFVKTAKTWQNVPEHHACITTFPTFLKREINDEIVTVVKFHTDACEGQKNEINFLEHVQLILDAYYPIRGHLSISIISPKGLLSMNLISMSTRTQLLSVRRKDRSSDGFRHWPFMSVHTWGENPRGIWQLHVEDKVNRPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNF3</accession>
    <name>A0A183HNF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010655">
        <property type="protein sequence ID" value="VDO58380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNF3"/>
    <dbReference type="STRING" id="387005.A0A183HNF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000901401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000901401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000901401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000901401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11942" checksum="E3566763B76CB844" modified="2016-09-07" version="1">MLFLTNLQANDKVGPYIFRLEVTDNKQQNDSTTVDILVNKAINSAPIPYAGGNQTFQLPIESVVLDGNVKDDGQIVSYNWFQIRQYLIFISKTTGYPRTNMKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNP9</accession>
    <name>A0A183HNP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity phosphatase, catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9109</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010837">
        <property type="protein sequence ID" value="VDO58741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNP9"/>
    <dbReference type="STRING" id="387005.A0A183HNP9"/>
    <dbReference type="WBParaSite" id="OFLC_0000911001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000911001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000911001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO58741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000911001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26805" checksum="377D3E8CABC7911C" modified="2016-09-07" version="1">MQDAGQINREEKLGVKALFEWRSRSWYGMTQILPYLYLGGLRDANDVEQLEEKQISHIVSIHELSGRLDGISKDLNILRIHMADLPEANISEHFAETATFIHRARLAKKSVLVHCVAGVSRSVCIVAAYLIVACDMSYAGALAYIVSKRPCANPNFGFRMQLAEYAGKRSLSDGKMMRSQFDSEAFDELKASDKKILQLDCPAASLSNASNESDVLNNIKSPSSNTSTKSIYLLYSNLIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPI1</accession>
    <name>A0A183HPI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9391</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011459">
        <property type="protein sequence ID" value="VDO60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPI1"/>
    <dbReference type="STRING" id="387005.A0A183HPI1"/>
    <dbReference type="WBParaSite" id="OFLC_0000939201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000939201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000939201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000939201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="14020" checksum="A8AC5F21D71291E0" modified="2016-09-07" version="1">MHIRKIFAVSSTSENILQGNMAEIYPSCDFSRKKWEYKEKQKTRIIIARSIEHVMEILNKLRERQKEGTIIEETVAGAEEQRDEAKESCMNIKEKLTKEENKLLEMEKEFEKEELLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ04</accession>
    <name>A0A183HQ04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011862">
        <property type="protein sequence ID" value="VDO61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ04"/>
    <dbReference type="STRING" id="387005.A0A183HQ04"/>
    <dbReference type="WBParaSite" id="OFLC_0000956501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000956501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000956501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000956501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25162" checksum="6021B769181AA71B" modified="2016-09-07" version="1">MHSWSILLLILLYCWLDIAISVIAFGFYQTSFKFNAQIIWDCVTFNVPYDFISSPVDFLIFAVFRLLVMLICIILKMNGEQSWLEKSFMPLLGVFILNWIFSLIKLLAFSEKIEQFAYFGFWLNVIWNVLSAALIIVIWNFAFRTNTSWGYRTLTSSEARDVTSSVEDKSNRSDTYRHILRLLEYCKKQWKWFAAGFFFLLIYSFSMNLYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ24</accession>
    <name>A0A183HQ24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9587</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011916">
        <property type="protein sequence ID" value="VDO61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ24"/>
    <dbReference type="STRING" id="387005.A0A183HQ24"/>
    <dbReference type="WBParaSite" id="OFLC_0000958501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000958501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000958501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000958501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11347" checksum="5CD2900FE4A25199" modified="2016-09-07" version="1">MKAVFAVATIGSACAVILSLTVIAIIFNDISKLYDNVMMEMEEFKMIAEDTWSEITYVNGNPYGTIKTAPFTLSSIFRAKRQSNKCSKFCFSRTASLILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ53</accession>
    <name>A0A183HQ53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9615</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011983">
        <property type="protein sequence ID" value="VDO61934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ53"/>
    <dbReference type="STRING" id="387005.A0A183HQ53"/>
    <dbReference type="WBParaSite" id="OFLC_0000961401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000961401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000961401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000961401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51898" checksum="06E3837EB7DE558A" modified="2016-09-07" version="1">MGSISIEGEEDEENGTEVEQEDNDKTPVLSRENSDVQNKSIKPMRKWKKSDEKRKIEEKSFSRGPSICSNSSKRNTIINDENSDKRNIDYKLRREFGTSSPCRRKIEGSPVSLRRSGTLEGSPSSIRKSVTFDPESPVSVRKSSTISTASLHSDSTLQASVPTELPESPILLRRGSSKRAERSPIIQRKTITDSGIYFASPLPPRRREMDPQSLTSPVIKRKDLETNSYSPVVRRKESLLSQTRHESFRRQSENSNSEPGPSSIRDNVTRKYSFPEDKIWYINGTSTYHQNVGEAKSFQMPVITSPILRTTNNHNKFLIRRASERVGNVETTMSKLLPRQSLPIKSDLKLNSTSARDLNSIPNKFDVNNSKDITIRSNPENRNRNNKPETHITSNNELRHSITNEIRKATVTNTSQIQPKLLSRQPSIKEISKCSTETAATSVKKDIRSHVPLQQREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ94</accession>
    <name>A0A183HQ94_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBX domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9655</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012081">
        <property type="protein sequence ID" value="VDO62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ94"/>
    <dbReference type="STRING" id="387005.A0A183HQ94"/>
    <dbReference type="WBParaSite" id="OFLC_0000965501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000965501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000965501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="74"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000965501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22094" checksum="9E998E8BBC057411" modified="2016-09-07" version="1">MAEAKMSREERERREIVEQKNREKREQEAYLKKLRQQIKADKEERMNGILNNSMEQNQKAKSALHQTDMPSSVSNSAGCRIQCKFSDGSTLIHQFASTDIFSQLIEIIKKDGRQGDDFYIVQMYPRREFPDITQTFAELGLTPSATVLVLSVNLYSFISCTFYCFYGLKMSSRISKFKNTSKIMFKYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQK5</accession>
    <name>A0A183HQK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9765</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012325">
        <property type="protein sequence ID" value="VDO63082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQK5"/>
    <dbReference type="STRING" id="387005.A0A183HQK5"/>
    <dbReference type="WBParaSite" id="OFLC_0000976601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000976601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000976601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO63082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000976601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18154" checksum="E29F6C7E1245E7A4" modified="2016-09-07" version="1">MIVPIIIQFLFEKTSKFFSRPMNLIAQAQSGTGKTATFVLTMLSRVVPSNKWPQCLCLAPTYELAMQIGQVVQKMSEFLPEIKIRYAVKGERMSRGEKIEEQIIIGTPGKMLDWVMKLRVIDPSKIICLVLDEADVMISQQGHQDQSIRLHKFRMIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR84</accession>
    <name>A0A183HR84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH_dom_type_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10001</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012868">
        <property type="protein sequence ID" value="VDO65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR84"/>
    <dbReference type="STRING" id="387005.A0A183HR84"/>
    <dbReference type="WBParaSite" id="OFLC_0000999501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000999501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000999501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF42">
        <property type="entry name" value="QUAKING RELATED 54B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000999501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19333" checksum="6BA39A881C000332" modified="2016-09-07" version="1">AAAAAAAAGADFHYGNAAGGGAGYNGAGGPPGAFPGGYAGAPGGYGGYGAPGYGGYGGYGYLDTQSPLDAEIQVVIREIHNEQQLMEQGGEWGEQFKNAKRLLAAEADKLENSIDPEWLEVDIAKPIKVSKKVLIPNFRHPHFNFVGKILGPKGATLQAMAKQFKCHIYVLGRGSTKDRAKVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRG1</accession>
    <name>A0A183HRG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10074</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013054">
        <property type="protein sequence ID" value="VDO65654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRG1"/>
    <dbReference type="STRING" id="387005.A0A183HRG1"/>
    <dbReference type="WBParaSite" id="OFLC_0001007201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001007201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001007201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001007201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25780" checksum="A5FC4F38B7CA72C3" modified="2016-09-07" version="1">NSCANKNELSQHAVPSSSSISDLSQDPASISVLNKIFSSPCQRPFHSQFLPESHVAPSVQGVLRVEDLERNFQKESIPGNPSVLPTSIDGFGNFVTNEQLPSNSRQSYLSQTIKGNPLGDPHQQAHLLNKLNKFARLQNGTMDDVARITEDSLTLPSKISLAPTHHLSGIPLNSQASSHPAVPPSFSDVTFHAAFLRSQYEKAAALHTLAANQRSTLASNTQAVDSTVFSLILVMYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSJ1</accession>
    <name>A0A183HSJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013944">
        <property type="protein sequence ID" value="VDO68599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001045201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001045201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001045201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001045201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5473" checksum="6FA6BE08D0F4BDC1" modified="2016-09-07" version="1">MGFVIEIRAKKLVRNGVILVIELNFSSENCELKLGTFCQEILWWSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSZ1</accession>
    <name>A0A183HSZ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10600</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014310">
        <property type="protein sequence ID" value="VDO69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSZ1"/>
    <dbReference type="STRING" id="387005.A0A183HSZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001060301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001060301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001060301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001060301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9324" checksum="090DF0DB3C1439C5" modified="2016-09-07" version="1">MSNSTKTKIALTALVFVYGTLKRGEPNAAILADPATGTQRFVGTGKTVNAFPLIIASQFNIPFCLNKPGIGKVSFTLSYFQNRGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTC8</accession>
    <name>A0A183HTC8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014676">
        <property type="protein sequence ID" value="VDO71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTC8"/>
    <dbReference type="WBParaSite" id="OFLC_0001074001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001074001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001074001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001074001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17438" checksum="CF2DA139876D1DC6" modified="2016-09-07" version="1">MEDPGKLYPCRRPAFYLAIELASMPQESLITPHIADFLEQMFETIPESNINSSLNLSNIDQNEMINSDVSIVEMDTSVIPLDVLFYLTVQSSTIRFEGQQQRTAAADCLLKLPSLTLMASTRPHCEGTTNSSVADTAGSGIHVVATLSAFSLNIYSPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUT2</accession>
    <name>A0A183HUT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016002">
        <property type="protein sequence ID" value="VDO75039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUT2"/>
    <dbReference type="WBParaSite" id="OFLC_0001124401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001124401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001124401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001124401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8893" checksum="BCA9632B3398202B" modified="2016-09-07" version="1">MIIALNEYGSNLLIQHFASIIMLITFLSPYLLLSLSTISYDFRLFARKVVEFYFSSHICYALFLSLFQLFIWRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV65</accession>
    <name>A0A183HV65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11379</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016375">
        <property type="protein sequence ID" value="VDO75994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV65"/>
    <dbReference type="STRING" id="387005.A0A183HV65"/>
    <dbReference type="WBParaSite" id="OFLC_0001137701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001137701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001137701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001137701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15872" checksum="28579FD727ED0D68" modified="2016-09-07" version="1">MLRSFQSELGTISSDMKRLQQQSIDISQQLQNRQKIRGELSQFVDDMVVSQNMIQAIVERDVGDREFLEQLHELQHKLQFLKAQEFRDAKATSDVHDVIENLKYKAGHGEDKRVATFKNFIFQKAVDKLSNSTRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVI3</accession>
    <name>A0A183HVI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11491</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016644">
        <property type="protein sequence ID" value="VDO76846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVI3"/>
    <dbReference type="STRING" id="387005.A0A183HVI3"/>
    <dbReference type="WBParaSite" id="OFLC_0001149501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001149501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001149501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001149501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15747" checksum="9445CCD82C4E5327" modified="2016-09-07" version="1">MRNERKNEQKEIVCENEISLTDEAEIDGNSNLESSDTAKHLEISDVEKQRNNVSNDKCQDENKMKEEMTDAGLKEDIGTLTISEYRDLVCKEGKLIDLVSITAEESLLKAACLLSKQRIHRLPVLDPFDGSPLFILTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVU3</accession>
    <name>A0A183HVU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS11609</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016994">
        <property type="protein sequence ID" value="VDO77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVU3"/>
    <dbReference type="WBParaSite" id="OFLC_0001160501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001160501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001160501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF30">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552650" evidence="5">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001160501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13637" checksum="3872AB417EEE90AC" modified="2016-09-07" version="1">MFINCVILLSLSIVSTFAMGSIKNITVQGQVACSDRSQKDVEIQLWERDTLDPDDLLNTTMTDSRGNFKVYGEENEVNNIEPYLIIKHSCDNGVVNPVNSIFVYKNSNLCNKFVFMLYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXM0</accession>
    <name>A0A183HXM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5678 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018725">
        <property type="protein sequence ID" value="VDO83000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXM0"/>
    <dbReference type="STRING" id="387005.A0A183HXM0"/>
    <dbReference type="WBParaSite" id="OFLC_0001223301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001223301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001223301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001223301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9009" checksum="2BD9387129BCD473" modified="2016-09-07" version="1">MTARRPVPLEHFLYTGQDGKTKKDMFKIIDSNGQFIQKGYSLASAAKANIRKANANVGPVGYRPNNKILSYFENSRTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP5</accession>
    <name>A0A183HXP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12254</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018791">
        <property type="protein sequence ID" value="VDO83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP5"/>
    <dbReference type="STRING" id="387005.A0A183HXP5"/>
    <dbReference type="WBParaSite" id="OFLC_0001225801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001225801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001225801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001225801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15716" checksum="D673C2B7C9FC426F" modified="2016-09-07" version="1">MAKDVQSLVFQRHKVANGTFGYVYTAKNLVDPASEKVVRLGREECSENEGCDYAIAIVNRRTGNVDYLPTKLICFENVPTSDFQAILDTGYKRKIDYSIDNSISRESWADKRRALTDDFGSVKRVKMLDAAKRRQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYE9</accession>
    <name>A0A183HYE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039857">
        <property type="protein sequence ID" value="VDP11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYE9"/>
    <dbReference type="WBParaSite" id="OFLC_0001251201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001251201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001251201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001251201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32242" checksum="06C7E245BC169E50" modified="2016-09-07" version="1">MLASLQYNNSPFLQFFSNENIGRLTQMATDLLASAAKHSAAANIESLTRPGHPEPGPVSLNSRPSEMFGQSITNALSPTITKLAEISTVENRGLMPSQHERKTYDTKSNSGTKSLIDIAEAFLGTSGPDKSNTFFGAKTQTYPKNADISLLPTIRQLAPGAINNFGIPKGEGCLPFLNEFMKIAYGNCVKVADAKTWDVWGNQITKALSGGKIDFIGASKETCKRGAERHHCGQLRKMISECDILGSLQVGMEMQRAIQRCEEFSGVIDQNPIQVLNQVNSIIGGEFAQGFLHKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZA9</accession>
    <name>A0A183HZA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12821</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SOLO family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039945">
        <property type="protein sequence ID" value="VDP12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZA9"/>
    <dbReference type="STRING" id="387005.A0A183HZA9"/>
    <dbReference type="WBParaSite" id="OFLC_0001282201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001282201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001282201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056804">
        <property type="entry name" value="Spectrin_SESTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46607">
        <property type="entry name" value="SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46607:SF1">
        <property type="entry name" value="SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24915">
        <property type="entry name" value="Spectrin_SESTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001282201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="715" mass="83136" checksum="AA029E2DCDB8C27C" modified="2016-09-07" version="1">MQQKDRLLIESSVIALPGCRDRTGSPLLFINFMDGNSKQLSVKRVNAPSYEELTSVISYLSQIPGENVRKLGFTIVIDGRKAIIKHVRGALRACQQALYRQIRFVLVIQPEKFLDQQKLNFELIKEAYQFKCTLISLHKLSRFVDVAQLPDVLGGTLHYDPYSWILLRQKLENYVKRANSWIENNKRLDSAIHTTSNQSALEEDSFNSSELLKAGNDLFDELTQNSGMRAVKKSVNVDWDSAAQNVDLLMKQIKNIQKRIEVMEHREERNASLKVLEDHTEGVHNLVNWILNAGERWLLTLHEIGESYDDAKQLLKEHNELEGKSIDLEEQSRELIAVGHDLQREFPKHTVALQQNIDSVQQLVRAFCTRVVRQKKVALRSVNFYRMLADFSRKTNLLLESLCTNVKAIDIATAEKERNEMESKVDEMEKIYHDMIISGISFIDELCIYESNSVGRPITRDYSAGIVHIREILEESRGRRRRCQNLADVRRLKIHQLLQLYTCEEDGQQAVLWIEELYETLVNGYDETLYDFKQLYLMQENRIKLEKTARSTYKYGKQLCQVVLVLRRSLRMEVQPGLKLNQKLESIWGKFCFALNEKETKLGIIGAFHSTIQKVSERLDELVLRLDGEAFEKRLEETSLQSFTDEKRSIANDIHELKQISDILIQELNNKISRSRSNTEISWVRALNEIQRKFDEIKRKQNKLEKIRKIKNIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZK0</accession>
    <name>A0A183HZK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12912</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039973">
        <property type="protein sequence ID" value="VDP12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZK0"/>
    <dbReference type="STRING" id="387005.A0A183HZK0"/>
    <dbReference type="WBParaSite" id="OFLC_0001291301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001291301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001291301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF17">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001291301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13269" checksum="9F411029FA1E5C0B" modified="2016-09-07" version="1">MNNRSYISSQLITGFRKLNSRPGIRALKEIRKYQKSTMLLIRKLPFARLVKEIANEVSDSSFGYRFAVEAIAALQEAAEAFMVQFFENALLCSQHAKRITVMPRDIQLVRRLFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZN5</accession>
    <name>A0A183HZN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lysine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS12947</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01039986">
        <property type="protein sequence ID" value="VDP12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZN5"/>
    <dbReference type="STRING" id="387005.A0A183HZN5"/>
    <dbReference type="WBParaSite" id="OFLC_0001294801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001294801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001294801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="16"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001294801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42272" checksum="30E39F3B0A8C4AD3" modified="2016-09-07" version="1">MRYLDLIMNPDVKNRFVTRSRMISFLRRYFDNIGFLEVETPVMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTTCEFYMAYADYEDLMKITEDLLSKMVHSIHGTYKIQYHPNGIDDDLVYEVDFTPPFRRINIYDGLQEKLGVQFPSADSLDTDDVPSFSEANKFFDKLAMENNVECPAPRTTARLLDKLVGEFLEPTFISPTFLTGHPQLMSPLAKWHRSVPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFEEQAKQKQAGDDEAQIIDENFCTALEYGLPPTAGWGIGIDRLTMILTDTNNIKEVLFFPAMRPEEKVTSPLHESTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZX1</accession>
    <name>A0A183HZX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NOA36 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13033</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOA36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040019">
        <property type="protein sequence ID" value="VDP12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZX1"/>
    <dbReference type="STRING" id="387005.A0A183HZX1"/>
    <dbReference type="WBParaSite" id="OFLC_0001303401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001303401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001303401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010531">
        <property type="entry name" value="NOA36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06524">
        <property type="entry name" value="NOA36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001303401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32940" checksum="74D72D55C81F0F54" modified="2016-09-07" version="1">MPKKKTGARKKAEKQREIQKKIRNNVVKEIALHPSNGLMACPHCTNTLRRLDLTENWQCDQCSRDQKTRAFCYFCSALNKAPVCAACGKQKCLMKSGDCVIKHAGKFTVGLQMVGAICDFCEAFICHSKKCLTNHPCTCPLRDAQCLECRRGVWDHGGRIFQCAFCQNFLCEDDQFEHQASCQQLDSENYKCMSCNRHGQYTCMRCKICCCDDHVRKKGFKYNKDMKELPCPKCGYATSETKDFSVSARKHAYGRQAQEDAYNYDSDERASNFSRYDKRKKRFDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0V8</accession>
    <name>A0A183I0V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13370</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040167">
        <property type="protein sequence ID" value="VDP13568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0V8"/>
    <dbReference type="STRING" id="387005.A0A183I0V8"/>
    <dbReference type="WBParaSite" id="OFLC_0001337101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001337101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001337101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001319">
        <property type="entry name" value="Gastrulation defective protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP13568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001337101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51600" checksum="95DE0C882146E594" modified="2016-09-07" version="1">MFFDLPNIIFHIINGLAFSSNGEKLLVASGHAQIRILDRQGKQWAETVRGDQYLVDLSNTKGHTGSVNACCWHPVAKSEFLSCADDGTLRIWSIDDYKEITRCINKQRKVIKTKNATGKRAIPTTCCYSRDGKYVAAGCNDGSIQIWKHGNLYVSVNTAYLNRTAHTAPITSLQFSPNIDGTLKLWQLETFNKPCHVVENLKNEFVSTDCGFAPHGEMVYTGTSFNDENGFDGMLVFFDSRSFDLVYRITYPKLSCIKISWHPKINQILVGLSDGSLRLYYDPVNSLRGALLCVSRPLRRARQQEVIREELVLSPLTLEMFQPRGEEGEEKEVTTWRLKKYLRMMDNKLRPEFRKPADMPMSGPSSGGRVAASGGTLHSYIAKQVGTKRNRDFLADTDVRASILRHAEEAEKNPYYVTKAYLKNQPVTIFQEKTTAPEEDEEADTELEPLYKISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I195</accession>
    <name>A0A183I195_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="7">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13507</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01040234">
        <property type="protein sequence ID" value="VDP13926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I195"/>
    <dbReference type="STRING" id="387005.A0A183I195"/>
    <dbReference type="WBParaSite" id="OFLC_0001350801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001350801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001350801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000115">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF15">
        <property type="entry name" value="SRC-LIKE-ADAPTER 2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="127"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001350801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35209" checksum="E1F92EFBCF8A6D07" modified="2016-09-07" version="1">MGNCFSGSPRQSSPSSGILNERNSPKFSTDHGSIEPLKEANCSEALTPRRQENHSLQDPTPGKEILVALYAYESRADGDLSFRKGDVMYLLDQSNSDWWYVRHSKGGTGYVPRNFVARQQTVESEEWFAGRIARNRAERLVLASNLPKGTFLIREREADTREYALTIRDSDDQRGGTVKHYKIKRLDGDAGFFITTRRTFATLRDLVKVADGLCCQLSFPAPRIAPTRPDLSHDTQQVGMHNREVIEQVELGYRMPLPRGCPEQIYTEVMLKCWDKIPDRRPTFDYLFHFFDDYFVSSQPSYVPPSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1C9</accession>
    <name>A0A183I1C9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13541</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01040256">
        <property type="protein sequence ID" value="VDP14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1C9"/>
    <dbReference type="STRING" id="387005.A0A183I1C9"/>
    <dbReference type="WBParaSite" id="OFLC_0001354201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001354201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001354201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10519">
        <property type="entry name" value="SET_EZH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="9">
        <location>
            <begin position="210"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="322"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001354201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52255" checksum="4C5A8AEB9001DFBC" modified="2016-09-07" version="1">DQVIYRAVYEQFPNKASVQQLPFLFEDLKRRFGPSDLFTEDNNQSEFLDTKALHSFQLLLCNRCLTYDCLIHGVNATEMEVRRRRGITSVEPCGPHCFRHLTKEMEEVKRRCVSPPDAKTINAILNIKTENINWTPQQETMFIALRRTYKNDFCKLAEVLNLVVENAPPKSCRELYAYSFRIAPISPRADISPNSPPKKKKNMKDQHRTFRAVKWAKTEGKVGNTHVYEPCSHSGPCSAENNCSCVSVDNLCTKFCRCGEQCKYRFPGCRCAPGLCRTKQCQCFYANWECDPDVCKSCKCDVLDDPNVATCKNVAMQRGLQKKLVIAPSQVAGWGCFAEEDIEKNDFISEYCGEVISHDESERRGKIYDKLKCSYLFGLNDEMVVDATRKGNVIRFANHSKDPNCMAKVFMVNGDHRIGIFARRPIVAGEELFFDYSYNSYQQVKVKFVSKERPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2A6</accession>
    <name>A0A183I2A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040440">
        <property type="protein sequence ID" value="VDP14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2A6"/>
    <dbReference type="WBParaSite" id="OFLC_0001386901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001386901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001386901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001386901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12938" checksum="E8FB0D2064AB0114" modified="2016-09-07" version="1">MSEKEPSESGILSAPIEENSSSNIIDHTTASYQQPPPVQPDLLLGPQSPVRSDMGLPPYREPPPSYQAAMAYPAASGPYSTNSNNTTFPKPYTAVPPYPLLSLRNQLFPPTTPPLLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I331</accession>
    <name>A0A183I331_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS14143</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040621">
        <property type="protein sequence ID" value="VDP15648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I331"/>
    <dbReference type="STRING" id="387005.A0A183I331"/>
    <dbReference type="WBParaSite" id="OFLC_0001415101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001415101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001415101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF334">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP15648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001415101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54729" checksum="E971878190419D5B" modified="2016-09-07" version="1">MFQTLSELLIIDLHQRIENVHFYFIFQNAKQQMVGWIISIITFIIMGSVLPEGISRRKNESKKGTATTSNNYLCQVCGDRASGFHYGVFACEGCKGFFRRSIQQKIQYRPCTRSQQCIVARNNRNRCQHCRLQKCIKVGMSREAVRFGRVPKHEKVRMAEELARVTARTLTDAGTLFQTIVLAMLSSLNSDKTLIMLHPPIRHVHQYFYSPLNVFLQKFSTLKLTNQQVALIGAAGMCISDKPLVHHPELAAFIHSRLSDLFQETFSEECRAAAPQLLHTILCELRMQNAVHQQSLEAITIWPVTCCSSSSSVASTSDDSTVSNTVRTGMSDGASRNTETELLILGNCGLLRGQQQPEQPLQELISPLSVENQSHDDIQKGQTRSGYNQCRSENNPESLQFPSGALSRPQPSIVETHRSVASLLNQPPILPIAIAAIRNSFTQNCQSEVLYRASTPMLRSTSLHMKASNEVLESTDEEPLDLSIKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3F6</accession>
    <name>A0A183I3F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14268</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040726">
        <property type="protein sequence ID" value="VDP16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3F6"/>
    <dbReference type="STRING" id="387005.A0A183I3F6"/>
    <dbReference type="WBParaSite" id="OFLC_0001427601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001427601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001427601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05128">
        <property type="entry name" value="RasGAP_GAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF148">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="91"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="338"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001427601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="66558" checksum="A6B43F723C53F749" modified="2016-09-07" version="1">MRYYLRPRMTGDESDDGIHDGTSDVLAGDNQNPLNGYQQLGELRLRFFYTAEHVLPFEFYKPLQMNLLKSLTLQPFCASPAGILEYLPSVDILTIARPLMKIFVQAELIRPLLRVLCSDNILKCQDINTLFRSQSLATKIIHEQMKFFGHHYLVISIKPVIDMIYCERKCCEIDPMKLKQGDSMESNKLNLIVYGEIAFSRVVDSSHRCPLVLREMFSDLRELAAQHFPGREDIQRLILSSFIIMRFFAAALMNPKSFGLKRDQPEGVVCRTLVLLSKILQRLSNCVVSANSLTEKEPWLSSVLERFTDEQHKLAMLKFLNTISMKETTADINGENLSVVRDGFFIERKTREKRRILKNLVNQKRRYVVLTENEICWQKTKADAEPKGRMRLQEVNQIEPVVDAKNVFKIASSDCEIQFQAPSTVEMNEWLDVLKQRKRQLMIALRTNESNDAFEIDTERELEAIHAIIYENAETLKQWKNILEGAEIPTVHPCIPSALQDQLKNNENPEQAKQLFYSSLQEILHSTLLIEKSHNEIVNRFIKQIRYGKGTRELPIGDDNYLLLKSRFRKSLDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3K9</accession>
    <name>A0A183I3K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14322</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040766">
        <property type="protein sequence ID" value="VDP16500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3K9"/>
    <dbReference type="WBParaSite" id="OFLC_0001432901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001432901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001432901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552752" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001432901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7784" checksum="D8241D170A92B3D9" modified="2016-09-07" version="1">MSCPTLVVVTILLQVTLVENLDCFTGRLDFGLMFAECSSSINYCVKATSIDPECGRVIDKGCDMENFCHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3S4</accession>
    <name>A0A183I3S4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14386</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01040813">
        <property type="protein sequence ID" value="VDP16825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3S4"/>
    <dbReference type="STRING" id="387005.A0A183I3S4"/>
    <dbReference type="WBParaSite" id="OFLC_0001439401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001439401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001439401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP16825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001439401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11793" checksum="0D2F806FE1C953BE" modified="2016-09-07" version="1">MSIRRRTKKVDISMPTNFEHRYHAGFDPVTGQYHGLPKQWQAIIGITPNRRGRPRPMVDPSCITPTEIAEIKTVVRGDLPESCQKPRLQYVLLKHQQNYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I419</accession>
    <name>A0A183I419_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14481</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the microviridae F protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040893">
        <property type="protein sequence ID" value="VDP17254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I419"/>
    <dbReference type="STRING" id="387005.A0A183I419"/>
    <dbReference type="WBParaSite" id="OFLC_0001448901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001448901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001448901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.169.10">
        <property type="entry name" value="Microviridae F protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016184">
        <property type="entry name" value="Capsid/spike_ssDNA_virus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003514">
        <property type="entry name" value="Microviridae_protein_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037002">
        <property type="entry name" value="Microviridae_protein_F_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02305">
        <property type="entry name" value="Phage_F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88645">
        <property type="entry name" value="ssDNA viruses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001448901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31135" checksum="6D5C992469791B53" modified="2016-09-07" version="1">MPHDLSHLGFLAGQIGRLITISTTPVIAGDSFEMDAVGALRLSPLRRGLAIDSTGYLNIYNNYFKAPWMPDRTEANPNELNQDDARYGFRCCHLKNIWTAPLPPETELSRQMTTSTTSIDIMGLQAAYANLHTDQERDYFMQRYHDVISSFGGKTSYDADNRPLLVMRSNLWASGYDVDGTDQTSLGQFSGRVQQTYKHSVPRFFVPEHGTMFTLALVRFPPTATKEIQYLNAKGALTYTDIAGDPVLYGNLPPREISMKDVFRSGDSSKKFKIAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6H9</accession>
    <name>A0A183I6H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15340</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041983">
        <property type="protein sequence ID" value="VDP21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6H9"/>
    <dbReference type="STRING" id="387005.A0A183I6H9"/>
    <dbReference type="WBParaSite" id="OFLC_0001535201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001535201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001535201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001535201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="25992" checksum="5AB5811E0A27CF46" modified="2016-09-07" version="1">MSTSRTQLNVAGSAHSSTSNVFSSGIGTPSVPVQQSSGSFGSFPFGTTGFGASSRDMLAAAQQMQSRQQQQGNLPGSMQIFGSNTGTNLCAPGSTTGPFTQSNELLKATNATNVLQPNFNGNHALSMSPSAQMMRTGFMSSGIPTTQARSGPGWSMPVGIPGTGGVRTTPSSSSGPTSTFDFRVPPGAPGSAGSVLNGNNSFVHNPAGQQQQQQSNGGSTGRITVPPAPMDDLTSVQFSEEIQNEANMYFQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6K2</accession>
    <name>A0A183I6K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15363</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042014">
        <property type="protein sequence ID" value="VDP21521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6K2"/>
    <dbReference type="STRING" id="387005.A0A183I6K2"/>
    <dbReference type="WBParaSite" id="OFLC_0001537501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001537501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001537501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP21521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001537501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15506" checksum="6FED9A7420E83F11" modified="2016-09-07" version="1">MYYLPACWYHSNRWLLNSNQFIIKRNSGTGQPTSLQEVSDVEWTSARCPISFENACISYALLKSVAAIDRSPDGRYIAVILSNGMIRFYQYPTTTILASYKETYGYSVSARNVAFVGKLLISDGSTDGAIYQWKLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7R8</accession>
    <name>A0A183I7R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042870">
        <property type="protein sequence ID" value="VDP23853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7R8"/>
    <dbReference type="WBParaSite" id="OFLC_0001579301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001579301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001579301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001579301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12713" checksum="F6EEE15C781442EB" modified="2016-09-07" version="1">MHGDPVKFIFCNDLNNWFFPFDEQWSESMRSAKLIIFFRSIVHEPYDIESVINSDIAPYIESQSIPICYAHQLDETPLDSGSRLFLMFGGRNVETSTFLVESIDEEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I810</accession>
    <name>A0A183I810_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15872</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043109">
        <property type="protein sequence ID" value="VDP24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I810"/>
    <dbReference type="WBParaSite" id="OFLC_0001588501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001588501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001588501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001588501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5982" checksum="3A7D48289099C58C" modified="2016-09-07" version="1">MALFWRQTVFLFGQKRSVVLMVLLFESHAIVFRIGVDLLNGRWTLVNDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I833</accession>
    <name>A0A183I833_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adipocyte plasma membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15895</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043164">
        <property type="protein sequence ID" value="VDP24650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I833"/>
    <dbReference type="STRING" id="387005.A0A183I833"/>
    <dbReference type="WBParaSite" id="OFLC_0001590801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001590801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001590801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001590801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15297" checksum="2493A4A466E5EB79" modified="2016-09-07" version="1">MGETEIFVDNLPGFPENIRLGSNGTFWVGLASVRHNDRFSLLDFLADKVYMRKCILQLVPDRYWQWLVSKFVKKHGLILQLNEEGQIIASAHDPTGQVIEAVSQVTETDEYLYLGYYRAPFIARLRKDLINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UDF0</accession>
    <name>A0A3P7UDF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001415">
        <property type="protein sequence ID" value="VDO33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H4P5"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="156" mass="17575" checksum="58A92A3902FEE68C" modified="2026-01-28" version="1">MSDLLKAMKKGLDSKTAPLATMKILSSFVRAVPIGTEIGNFLVLDLGSTSFHVLLIKSDRRNVEMDETIFCVPDNITSGTSEELSDHIAECMVHFMEERDLKHDGMLLFPCQKEDLTYAKLISWTKGFSESNVENKELSHCCMKRANVARILTSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V2T0</accession>
    <name>A0A3P7V2T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002735">
        <property type="protein sequence ID" value="VDO38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H8Q4"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="210" mass="23182" checksum="ECDAAC9ECC1E0829" modified="2026-01-28" version="1">MVWQCELLLLLILCVMNIYATSDDEPKGPKVTDKVVFTIKIGDEEIGKVTIGLFGKTVPKTVKNFIQLSKNTKGEGYIGSKFHRIIKDFMVQGGDFINGDGTGGKSIYGKKFADENFKIKHYGAGWVSMANAGPDSNGSQFFITLKKTPWLDGRHVVFGKVLEGMKVVRKMENTKTTQPGDKPLKDITIANVEYTAIDAPYAVHKTDADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W737</accession>
    <name>A0A3P7W737_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009911">
        <property type="protein sequence ID" value="VDO56576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W737"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8390" checksum="F5C64251988CFC0B" modified="2019-02-13" version="1">MESLIGCLLSVGYDLERQCPEQLAILKDLIRDAFIEVQEPWARKMILLLMELGASGWKLPSEANEYYFQHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XHF8</accession>
    <name>A0A3P7XHF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000549">
        <property type="protein sequence ID" value="VDO28772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H174"/>
    <dbReference type="OrthoDB" id="5787224at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="266" mass="30416" checksum="36D13434EC83ED54" modified="2026-01-28" version="1">MSEVPDVSENLNSSCEPVSESVVSVVIPENDESLQMDAEDSLPASSFSMHHSTNISNAPFVTCSPFTSKLRSFEQREIQPNERDVDVEFFAHLLIFYMIKEDWAKARQCRLRAEASVTNIHLNTIMFVCHHLEDGDTGAALHLIKNSHFDDQIKDLMMEVQKRIILSVLRMVERTYINIEANKLAKMFDAESNDELQKILDRVGWVVEDDYVIPKMTPQLMHKIKKLDASYGPISETSPRVPYEMMKGSVDINKLIQYATFLEINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XPC1</accession>
    <name>A0A3P7XPC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011500">
        <property type="protein sequence ID" value="VDO60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XPC1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="107" mass="12138" checksum="48F653FA0A603873" modified="2019-02-13" version="1">MQAKLENAKRLVPHENLLKYKDTKDADGFVPNLVAKTKAAFAHYQLRFVTEPGNAMYEATVQYDILGNTVTVDMTSISHVNRYGDLSHCIIDINYFLAAYCVCYDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YNY3</accession>
    <name>A0A3P7YNY3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004559">
        <property type="protein sequence ID" value="VDO42868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YNY3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000078">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000139">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000859">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF33">
        <property type="entry name" value="EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO42868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="373" mass="41244" checksum="B7D1336D1C84D7EC" modified="2019-02-13" version="1" fragment="single">MILDIDECLLLADDCLESQRCLNTPGSFKCIRTLSCGTGYALDSDTEQCIDVDECNLGSHDCGPLYQCRNTQGSYRCDPKKCAEGELMNPRTGECTSMDCPIGYKAVRGRCEDVNECQVRAPCKQFEECINTPGSFRCQDRGNICANGYRIDRETGFCVDINECVDGTHLCGEKQCINLLGSYKCRCSAGFEFNVTTKRCEDVDECKKFAGHVCSLHATCENTYGSFKCHCKDGFKIAKDARNCDDIDECSLGKANCTQKCINIPGSYQCICERGYRLGIDGITCEDIDECTLWAGSGDDLCMGKCINTPGSYKCQCPTGYEIQEDGRTCKDIDECAKGECQGSNQICVNTLGSFKCHVIRCPSNYVHDKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z4F8</accession>
    <name>A0A3P7Z4F8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005084">
        <property type="protein sequence ID" value="VDO44135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z4F8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000084">
        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO44135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="355" mass="40105" checksum="3B3042B5509E8D6F" modified="2019-02-13" version="1">MKSWKAEFQQAIEKIKQLPDEQDIPTKLKLYGLYKQATIGDVEGKRPLLLSPSQAKYDAWKEFKGKSMDEAQKMYIDMVNKLSATDAEASPPATCDGLKPVPGLDVIIEDKILWIKLNRPYKYNALTYEMYNGIANALNYANEIDTTITAFTGSGQYFCSGNDLSNFTNINGPEDIPRMASEAGQVLKSYVTAYINHKKPLVALINGPAIGIAVTVLPLFDLVVACDKATFSTPFTSLGQSPEGCSSYTFPMIMGYSKASEILIFDKKLTAQEAFERNLVCRVVPSLNFREETETYVRKISQLPPESLFYNKELLRNIHREALLAQNEREISLLMQRWQSTECRNAIQRFMIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY61</accession>
    <name>A0A183GY61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS171</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000044">
        <property type="protein sequence ID" value="VDO24834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY61"/>
    <dbReference type="STRING" id="387005.A0A183GY61"/>
    <dbReference type="WBParaSite" id="OFLC_0000017001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000017001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000017001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001924">
        <property type="entry name" value="guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO24834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000017001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21986" checksum="2CB27C9DA7D77C18" modified="2016-09-07" version="1">MFEEAKHYARAAAYKQQGLSRNLEISALWDIETGQQVTPFTGHTGDVMSLSLSPDMRTFISGACDASAKLWDIRDGMCKQTFPGHESDINAVSYFPSGHAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDSMRQERAGVLAGHDNRVSCLGVTEDGMAVCTGSWDSFLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYF4</accession>
    <name>A0A183GYF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS264</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000074">
        <property type="protein sequence ID" value="VDO25179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYF4"/>
    <dbReference type="WBParaSite" id="OFLC_0000026301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000026301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000026301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000026301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17360" checksum="7E691C9A5579DC31" modified="2016-09-07" version="1">MTIPIKSYNNQGKVSSYLSESYFILIKLYAEYNSLNHQKTEHIEHVEETAAVKKTSISELQMINAKVHAIEQSTAIIDCNATKLVVVTQPEEMVNKHLNDNLSDFIFDDNYFEDSWGLHSNLLFATYMHQMNTFTSTTVSISCSFDFSNTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ57</accession>
    <name>A0A183GZ57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS517</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000178">
        <property type="protein sequence ID" value="VDO26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ57"/>
    <dbReference type="STRING" id="387005.A0A183GZ57"/>
    <dbReference type="WBParaSite" id="OFLC_0000051601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000051601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000051601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="106"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000051601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63069" checksum="B2AF2B06EF6AD551" modified="2016-09-07" version="1">MPVTQETLFYRSKFEVHFEMKFDELLFTNLGEFGRYQKIQFILVCLPIIFVSMHALSWTFSAASVPHRCRLPNEGLDASYWTQSDLLIIAENCTEKKGRCRYQECQLRNDSTCRFGYVYDLSEIKYSAINRWQIVCEWSVLKAFIQSTYYIGQMGGSLLFGFLGDRIGRKKVFFIAIIILIISGVLMAVVPYWTAFALLRAAVGFAHPGIFVIAVVIGMELVGPSKRKVASVISGIFFSFGQIILGCLAYFIRDYRYLQLAISLPALIFMCYWWIVPESARWLVAQHKYKEADKILQRAAKINGARLPEKWWDQIDFPEKTAQNRSPQRKYNYLDLVRTPRIRMRTFACLFLWPVVSMIYYGVSMKTDFLGGDFYGTFIIGGIAEIPALLLIFAFIDKIGRKPLFAGGYFLAALCMLSSLLLPAEVHWIISVLQFLIAKASITGCYAVIYTVTPELYPTVIRNLAMGCCSMVARVGANLSCYIVMWIVERFGAWAMIIPFGSLSLVAGLVVIFCIPETVGKPLPETIEEIEDNYRSANEELLTLSNASKKKNDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZE9</accession>
    <name>A0A183GZE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000214">
        <property type="protein sequence ID" value="VDO26389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZE9"/>
    <dbReference type="WBParaSite" id="OFLC_0000060801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000060801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000060801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000060801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4733" checksum="F0C4EB85C856459C" modified="2016-09-07" version="1">MDIRRGGNCSIKIKKFSMIAMLSRNSQKKTSDNERPTSDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0B9</accession>
    <name>A0A183H0B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor SLU7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS929</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000380">
        <property type="protein sequence ID" value="VDO27605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0B9"/>
    <dbReference type="STRING" id="387005.A0A183H0B9"/>
    <dbReference type="WBParaSite" id="OFLC_0000092801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000092801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000092801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000092801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24860" checksum="9DE5ABC1D577AD04" modified="2016-09-07" version="1">MPTGKEQDKRDNYKKPQNKGFSTASWEDRLADNREEDDGAITDPELIAEKEYALEHGTEFDVNLNGGGDLAMVVGSEPERKSADKAKKDTLISAKIKQAKADRKARGRGVSGSMCKKDKDISYGGFHTLMDMDVYYGLDDEYGTYISDTEEPFDGHEDGYEGAVCQDKKEKIDQSKTDLISEDVNKMSLNDKDEGEDSDRPGPSRSHHGTSDDEKPKRLYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H135</accession>
    <name>A0A183H135_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA-decapping enzyme 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1195</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000527">
        <property type="protein sequence ID" value="VDO28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H135"/>
    <dbReference type="STRING" id="387005.A0A183H135"/>
    <dbReference type="WBParaSite" id="OFLC_0000119401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="279"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53298" checksum="9ABDC93137CD3E4F" modified="2016-09-07" version="1">MRLVEIASSNYARRYLVFVSSNREAQRRPELMSDSMSSMMRKHYPTRMVIYNRNLRSFDSSDVSGSVFLTCSCTGHFHFTFHKAQKSNCLFLVKNLCLCTGLARNEYLRTTSGSGERYENSRRGRQKNGSKKSSVGARMYKGSNDFGMFSSLNCGPDCLMTAIFSGSSTEDGKSSDSRTKNSMSFGPPIPDDILDDLCFRFLINIPDDQKNTPVRLCFQIELAHWFYIDFYCKRNNANVKCPEVSLRDLVGQIFNHCDFLVQYTDSVDKVMEEWRIYKSGVPTYGAALLDSSLNYVLLVQGYFAKNSWGFPKGKVNEEEEAMACASREVMEEVGFDISDKICKTHLIQCFVNDTLIRLYIIRDVPIDFPFAPNTRNEIGKIQWFCIWDLPKDRNDVVTCERIGMSPSNFYTVIPFVKELQAYVCRYHNMHNKPRHKPMDAINISTRSSSAFSPVQPQRTFLFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H168</accession>
    <name>A0A183H168_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000547">
        <property type="protein sequence ID" value="VDO28757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H168"/>
    <dbReference type="WBParaSite" id="OFLC_0000122701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000122701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000122701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000122701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18069" checksum="F8E90D4800849858" modified="2016-09-07" version="1">MLQCFPTLPAKRDFLIRDYVKLTNEMGKKNYGKNRATTKRYHINFRIFLMGKRILPKRLRQHFCFSLHIRSGHKSSCYTTYFGEGDVKDSNNTNNVLGVTQQIFELISLPINLFACRNLEEKEKSGCLPHNNLVMVVIWQVSVNDEGHLWTDTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H327</accession>
    <name>A0A183H327_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1887</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000987">
        <property type="protein sequence ID" value="VDO31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H327"/>
    <dbReference type="STRING" id="387005.A0A183H327"/>
    <dbReference type="WBParaSite" id="OFLC_0000188601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000188601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000188601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000188601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12591" checksum="9567296A592559CC" modified="2016-09-07" version="1">MGSKKDEISPSDVTLNMDSIKQVNAKPLRANAFSAEEEMRNQEEHEKQKIGHRRIDRQGEVSYKRVPSNALMGAIQLGIANSVGSLASIPKRDLLLQDFDVIHAVSFPSYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H383</accession>
    <name>A0A183H383_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1943</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001033">
        <property type="protein sequence ID" value="VDO31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H383"/>
    <dbReference type="WBParaSite" id="OFLC_0000194201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000194201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000194201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000194201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3163" checksum="51BA0ECDF2A3C369" modified="2016-09-07" version="1">MGGVGVCEWWLRDRVGVIGGPCFVVFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3W6</accession>
    <name>A0A183H3W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001196">
        <property type="protein sequence ID" value="VDO32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3W6"/>
    <dbReference type="STRING" id="387005.A0A183H3W6"/>
    <dbReference type="WBParaSite" id="OFLC_0000217501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000217501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000217501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000217501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19015" checksum="D9C4CC04D472685A" modified="2016-09-07" version="1">MVSKNLLCMLRELTLGPSLQGQPGIPDRITLSLLDDVACAFALTNHLILHFPFFLNASLISTMFLNFHAIFHAGYCHSLSVVTLEVAIRYLNSQKKKKNHPMMTTTQQMSKKRKAVQDGIFKAELNNFLMKELAEDGYSGVEVRRTPARAEVALFVIFYIIIFFESCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H471</accession>
    <name>A0A183H471_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XdhC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001277">
        <property type="protein sequence ID" value="VDO32473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H471"/>
    <dbReference type="STRING" id="387005.A0A183H471"/>
    <dbReference type="WBParaSite" id="OFLC_0000228001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000228001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000228001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000228001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19579" checksum="FCFE537C42CB0AD2" modified="2016-09-07" version="1">MIAQLKNTEQRQMIVIEKICPKEFLLCLLIKDETFDGRQDLVLRTLVPEKFPDFVIAQILLQTVTGWQSWLSAITRVQCHAVALLPSNYQQIMLTAPFLTESLSKVDSAVGYDRVLLIGLGARSIANYIHHNLFRVEIDELIFPEKDQYLNKLWLRNPTWNHLTITDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H486</accession>
    <name>A0A183H486_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SOCS box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2296</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001289">
        <property type="protein sequence ID" value="VDO32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H486"/>
    <dbReference type="STRING" id="387005.A0A183H486"/>
    <dbReference type="WBParaSite" id="OFLC_0000229501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000229501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000229501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000229501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38241" checksum="369E9AD1ACE1E6A2" modified="2016-09-07" version="1">MCMVYFTNSEVGEVLQSNAMCITASELYREEHEYMLKFLLVGDSDVGKDEIANFLGPAVSFTPNAFFIHEYIGLLNRFTVFLAFAVPKTTTILLEGKFVRLQLWDASGQGRFSTIIKSYSRGVQGILLVYDITNRWSFDGIRRWLAEIDEHAPGVPRILIGNRLHLEFNRAVPRREAEYFARKRNMQYFEVAFFILSYSVESVNKFPKPLTISTLAYFNVHESITELARLVISRNGMHWLWKSSQVASLQDLCCRTIVKNILNVHAIDRLPIPSFLQLKVRSFVSGADLCMRSVIRRECTTPYCNSATKYITRFVRSRNTKDHLRNANCDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4I1</accession>
    <name>A0A183H4I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001370">
        <property type="protein sequence ID" value="VDO32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4I1"/>
    <dbReference type="STRING" id="387005.A0A183H4I1"/>
    <dbReference type="WBParaSite" id="OFLC_0000239001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000239001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000239001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000239001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44549" checksum="CDBCC8DFAF51455B" modified="2016-09-07" version="1">MYRHIFRYTQTSISNGSDSSVLARERLYNRRSADDDDFSRSSSRRTSRYRSKLEKARKEFLSNDANSASDAVSERFRQTSDDILRSRPEYHSPLSQKSQKNEFSSKPELNQFPYSSIGPSPYDQEYNRLFERAERYWMPYKQRLSQPNLYSRTRGYSTSYLETNLDTGIGDIVSAQRQVEETNLDDVHRSGSMINYNRFSRRDAPQSIVVHVRSKSADYLMDRKMREESAPPENELQKFSEKTPNVSEHELRFRKSTEKLHVPDWYRERHIGRSIEHERRTVPAGTYFDHSSSVSYNGTRRTECEMSEMRYTTPLCYEQGRYSAPPQVVPISTSSLTSGAAVVIPYGMFDKYKDEIEEMRRSRTSLNQIGTSDDKRKVCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4R9</accession>
    <name>A0A183H4R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2479</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001434">
        <property type="protein sequence ID" value="VDO33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4R9"/>
    <dbReference type="STRING" id="387005.A0A183H4R9"/>
    <dbReference type="WBParaSite" id="OFLC_0000247801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000247801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000247801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000247801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34561" checksum="89D2406411D72F75" modified="2016-09-07" version="1">MLGEVGEKSVNRMEARSDKDSDNSACATSSDSNDDSAGSSDEVAQRNFRQLYEPPPNDVNATAYDCSQNPGFTWKMVLSCGLCDNEEYRTASLVDELEKKYLCNVDIDESIILLKSMTGTSPCKLASEHTLLLLVLNHKYIDRIGDKVDLAWNKLSSWEEIIAIFSLPRLEVLNLGYNPLQSFLTVPSFPLAMNLELFILNGTDLPMSTVRRLLNKMPKLKELHLSENRNLKNRFDVSDEVMSISLESLHVSKCDIEYWETVISLWRFFPNLVSLSLCENPIRYTSCKMKVVVSSFFRSCVVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H665</accession>
    <name>A0A183H665_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2976</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001858">
        <property type="protein sequence ID" value="VDO34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H665"/>
    <dbReference type="STRING" id="387005.A0A183H665"/>
    <dbReference type="WBParaSite" id="OFLC_0000297501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000297501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000297501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000297501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="571" mass="64009" checksum="874C6FF7BB554000" modified="2016-09-07" version="1">MSQLLYIFNVVILPLICYFKLDIAKYKLCCRREEGKYKNNVLICSNRKKGLLFVRSSRLKERVGNAVEAANRAATIAQQKADIAVSRTTTARERSEQADFIALQAREDADTARICAKQFVPEFRQLGTEVIRAQMNCLQQQHSTGTITSANHVSFDSPPTPKSSHESRDLSDELVILNSPSLPGASAETTYSPSQQPQTPGGISYQPQQSMVNLSSYQQGIMTNSDVDCTPSPLQQQHHQSSNPGGYQSNSGFQGSNVASIYQQQQQQQQPQQSVNSIGYAGPQQTSVFGPVSYQMLPSASSSYKIAGYQASTQLPAISSKPLPVVQMPYISSSSSYRPNAVPHHNVNLPHQYQQKQQHHQNVLASYLDTGFTIPDQQSFILHSDITSLEQPNNATSNITGELQQRQFSNGTTDPYVIQNTSPASSRSLLQNLYRRSTLATASDKRLENVVRRGREGGGGNDEYDEAEGRGSLPNLVELEVSGVHMRREEAARLASQQRQELQRLLEEEQLLRNNPLRYLFHPAFRNCMYTSLQAWIIRWKMPLVLSVANIFLLMVFYNLLTYEKRAHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6E0</accession>
    <name>A0A183H6E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3051</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001920">
        <property type="protein sequence ID" value="VDO35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6E0"/>
    <dbReference type="STRING" id="387005.A0A183H6E0"/>
    <dbReference type="WBParaSite" id="OFLC_0000305001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000305001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000305001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000305001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16872" checksum="4C7DE2FC27DA24AD" modified="2016-09-07" version="1">MPEGLKHSLKKMENNRKNDLHRQLNHCFPCSLPPKKQVIFKESTYESRHLPKPSITSILSSLLHSQPINNAKKKDFAYSSSDDESREPGNTNTYNECSKNLNDSDSNITCHNFYNQEKLDNVRDKDRYYTICHSRDFETNEKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6P2</accession>
    <name>A0A183H6P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3154</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002023">
        <property type="protein sequence ID" value="VDO35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6P2"/>
    <dbReference type="WBParaSite" id="OFLC_0000315301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000315301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000315301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000315301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11139" checksum="21AD0D8E0DBC1295" modified="2016-09-07" version="1">MDFDDLDSKQHLSSVKQTKSEKTTTTSASSASSGKASIKHEDSAEIARLVLQLNAAVQNKMTAEEASKSGRAQQARERLRRKFEEGQKSQKSKKKGRDGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H993</accession>
    <name>A0A183H993_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4056</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002936">
        <property type="protein sequence ID" value="VDO38723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H993"/>
    <dbReference type="STRING" id="387005.A0A183H993"/>
    <dbReference type="WBParaSite" id="OFLC_0000405401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000405401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000405401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO38723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000405401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26221" checksum="E40D2FC138E52E0E" modified="2016-09-07" version="1">PANWCVISYYEFNTKVGETFAVSAPAVYIDGGVDPSAPGRFCLGSLSNVQRTDESERCRKHIGRGIRLDVKGEGDVWLTCLSDRPVFVQSSYLDREAGRVPGDAVHKIYSQATLKVFDLRQCYHQLRQQNMYQLIAAEILNNSSDNTRNPLFGMDRKSAEFAGRLNQAANVGVDELRNLCSLAVSFVKGWGPDYNRKSIKETPCWIEVQINRALQLLDEVLHNPTLNSFSSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9G6</accession>
    <name>A0A183H9G6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003021">
        <property type="protein sequence ID" value="VDO39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9G6"/>
    <dbReference type="STRING" id="387005.A0A183H9G6"/>
    <dbReference type="WBParaSite" id="OFLC_0000412701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000412701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000412701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000412701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51234" checksum="14CCCE1DD81F34BB" modified="2016-09-07" version="1">PVASKQADIVVACGDDDALRLIVGKNCKNGNIEEGTGNVTQETDAEIVLAVVESLKNITVRSLGEETGPDKLTNKMIMAEYYKTLPIDWDGAPEFQWRMCKDESDRRVVIFENVLPADMRNPWFYTALLRCKRVIMDFPLSAGKIDADFDHLYGRIEAYFQSDHPIAYCAVNNLIHIRTGAHRVKIYLPQTKWVRKYKDILESRLGRMREPMESMRYLIVKPISDEVTEKQIRETCFKNYPIESVRFERDMLGQRMAVLLFPTAREAVAAHSNNDFIHFGARNVSSNYVKVYFPNVDFHGWDRLIVPTPETDMYCLLTYKEFISYTQSKKVEQEQEKLSKTSVTMETKQIRNDNAEMTQDRKLAFETERKKDIIESVGGNNSDSNATRFCESIKPAEKNVGVRNLQSKPTFPKKSQSSGDAKRVVEDNGSGPIRKRRRLIIKIFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9K1</accession>
    <name>A0A183H9K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SURF6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4163</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003059">
        <property type="protein sequence ID" value="VDO39135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9K1"/>
    <dbReference type="STRING" id="387005.A0A183H9K1"/>
    <dbReference type="WBParaSite" id="OFLC_0000416201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000416201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000416201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000416201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24204" checksum="67429ED39390E479" modified="2016-09-07" version="1">MVEKGKDDRQLAWIYEGTKSLVNREDYLLGKRVDKNFELYSDAVIKEKESGIEAIEKPQRYVNASSSTKISNLEVDIVRTEDPLVAIKMKEERIWQEKMENPLIQLRMQKLMKKVIEKREKKRLKKLKKLERKEKKRKHSTECNDNVDHVEKKRHHVDDEKHATVSSGTTKIGKSSSSESDNNEDEDKIYKKSRKEKYGLVKTGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9L6</accession>
    <name>A0A183H9L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CYTOSOL_AP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4179</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003076">
        <property type="protein sequence ID" value="VDO39199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9L6"/>
    <dbReference type="STRING" id="387005.A0A183H9L6"/>
    <dbReference type="WBParaSite" id="OFLC_0000417701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000417701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000417701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF4">
        <property type="entry name" value="AMINOPEPTIDASE NPEPL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO39199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000417701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="23689" checksum="824EB497451423C3" modified="2016-09-07" version="1">MKNDMGGAAALLSSFYMLIKLGFKQNLHCLLCIADNAISPTANRPDDIITMLSGKTVEIMNTDAEGRLVLADGVYYAKNTLKADTIIDMATLTGAQGLATGKLHAAVLTNSEEWENRACKAGRASGDLVHPLPFCPDLHFNDLRSTVADMRNSTFSKMQGPATSIAGLFIASHIDFGSGLNWIHFDIASPVESCSRATGYGPALICALLASDLDVPLLKTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9U5</accession>
    <name>A0A183H9U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003157">
        <property type="protein sequence ID" value="VDO39442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9U5"/>
    <dbReference type="STRING" id="387005.A0A183H9U5"/>
    <dbReference type="WBParaSite" id="OFLC_0000425601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000425601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000425601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000425601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62954" checksum="E3BCE07AF66109B7" modified="2016-09-07" version="1">ILPSKSTLWKIIEPPVVEHIRASFRNHDKKHSNLLNSEINMTLHFILERCLLLLIFVITLTLRYFRYFFVARENIVHFLADISLILLPLLGPMIPVFCLIGKNLGFVLGDDRNLQHSESNSEVVAACIFVNRNRKGSITSGFKTIYQYFTGHFHTSMDFVFTCGGLTSCTFLDKKGLLSWPNATIEKVLCFHSDGKGEERKLVPKILDLTMNGVESFPVHFDDSSWLECYKGSLLPFGISSILNGCSLLPDYTLFLDHINGISETVPNTISISNRHCLCPLTQLLGIGDEVLGKFNASDTKTIGFYKRLQGEGSDNELRKFRMPLENAFVTITKDAISKYYHIMSQGTADLLLDACTHVWCDNFLEPYTPNLHKRVLDFYQRNTMTGFCLVLGYRTLGCTISDTLSGKYIDISLLEKYEEVKERISIPRAISLDMELLKEFYRQSPLHTAYECFEEVMHEQTLCGLLALQYQARSDVVQLVEQLGHACIRFIYFSKENELRSRVFAEKLGLEAGWNCHISLVSEDERYEIFDVGKYSYRHPTELALHRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAT0</accession>
    <name>A0A183HAT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4592</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003556">
        <property type="protein sequence ID" value="VDO40434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAT0"/>
    <dbReference type="STRING" id="387005.A0A183HAT0"/>
    <dbReference type="WBParaSite" id="OFLC_0000459101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000459101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000459101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF65">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000459101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16637" checksum="FD20904A644B2312" modified="2016-09-07" version="1">TNVSHKIPKKWCNQLAINIIPAILIGPFVIAFYTYKTYVSAGSLGIGIIYGYFVIGVIVNKFLLSPMVKWNARVEKAEGDFRYKHVSIRNNAESIAFYEAEPFEQYECNRIFMLLWWRQFKFMCWKLPNLCKFIKYQIRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB41</accession>
    <name>A0A183HB41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003702">
        <property type="protein sequence ID" value="VDO40791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB41"/>
    <dbReference type="STRING" id="387005.A0A183HB41"/>
    <dbReference type="WBParaSite" id="OFLC_0000470201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000470201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000470201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000470201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13485" checksum="9297D64770257843" modified="2016-09-07" version="1">MEQFDICKLLSKVRLMIDICPSLQLLNRNIFVVLQGNEDSASIRLRAEIERLRKESGENSDDEMGDTKSSSGSSTVASSESGDSDSECNDGSRRSASMVSKNMHISDDSRSRSSDSGDDDDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB71</accession>
    <name>A0A183HB71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4733</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003743">
        <property type="protein sequence ID" value="VDO40890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB71"/>
    <dbReference type="STRING" id="387005.A0A183HB71"/>
    <dbReference type="WBParaSite" id="OFLC_0000473201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000473201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000473201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000473201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34537" checksum="E3B098E65B9811CE" modified="2016-09-07" version="1">MLIPVKSYDCTHLQCFDLSNFLKMNEKRPTWKCAVCSNGAPYKKLMIDGYFERVLKDTTSNITEVELLHDGDWRPINEENKSVSDNEEEISSSNDSKSHAQSIKNSVLNNGNRMNVVVDDDIIILDSDDDNEILQQLPSQNSMSRAQKRNITPSVVCIDLDDSDPVDLSPHSYQASRISSTPLSFSNSTSMVTSTSSASTTGTVITIGGSTQISATRPVMHYSQQQQQQQSPHPSQSMPYFPNPAVSLVPPPDAVIAGTNNSNYFHSFEQPYPYYQQDFNTRLIAEELRQFMANIQQSTSAPNFPRYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBH9</accession>
    <name>A0A183HBH9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4841</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01003877">
        <property type="protein sequence ID" value="VDO41219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBH9"/>
    <dbReference type="STRING" id="387005.A0A183HBH9"/>
    <dbReference type="WBParaSite" id="OFLC_0000484001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000484001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000484001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO41219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000484001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38572" checksum="77CEB28AF7DF6AD5" modified="2016-09-07" version="1">MRILITGAAGFIGSHVTLELLEAGYDVICVDNFSNSLQDSDGNAVSLKRVSQIINKEVPFIFADCSNEEQLENVFKKYSINGVIHLAGWKAVGESVKRPLDYYSNNLTATLVLLKMCGKYNVKNFVFSSSATVYGSPTNLPIKETDPVGYKITNPYGHTKYMIEQILMDLANSDKSWNIIILRYFNPVGAHPSGLIGEDPKGVPNNLMPHMSQVAIGKLPVLYIFGTEFDTADGTGIRDYIHIVDLARGHVAAFDYLNKQQNFGCEVYNLGTGKGYSVLEMVAAFEKATGRKVKTENGPPRPGDIACIYCDPLLAAQKLGWKCKYSLEEMCLDLWNWQVKNPNGYIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCB7</accession>
    <name>A0A183HCB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004248">
        <property type="protein sequence ID" value="VDO42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCB7"/>
    <dbReference type="WBParaSite" id="OFLC_0000512801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000512801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000512801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552477" evidence="1">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000512801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12519" checksum="D71613F8D5C51A4A" modified="2016-09-07" version="1">MSRETMCTSYHFTKCFTLLILLQSSIAIPVSYSRKLTLNPDEFLLTYVPSENSLSRGAYESWSDVLEDTHSDRVHYLPFRRPTRNTGGADEARYHIRHVGDLPMFRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCJ8</accession>
    <name>A0A183HCJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3819 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5212</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004355">
        <property type="protein sequence ID" value="VDO42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCJ8"/>
    <dbReference type="STRING" id="387005.A0A183HCJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000520901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000520901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000520901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="3">
        <location>
            <begin position="227"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000520901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57507" checksum="3519382BD13BB259" modified="2016-09-07" version="1">MTTYFYRFQDFALEPDEQKMRRASQHMIRAMTAGMASITCREPLSSTILGFLKTAFTNSLRCNITPEQQKLIDEAATTIAEDNVELATNFIVKTACEKATPEMDKRLESEFATRKQSRLEGRQYADPVALARAQQTPEKIRLRIGSVTNQQMVVYDEFSSRICGFKPTTAEDMIVDYSVMKSSTPTAMQPVIQQPGMDKEVEQFVTALQVLLHDIDSVLSAYGVPNYRASAAIANIRDAISQLASNPREPIQMHNCIQRIVEQVLCAYRNAELQQHQLSLPEADWNRRLKDVFLQLCRILLTQIPLNDLARRVTRVIVDCRLDYRFNVDAMDLLAKHMLIQMNVYDQNLAMLIDSGSNFEALIFAQRFLKLLTINNPTHSRQAVSESMPLTMEQLAKAQQFGQNRPTPESFTTTALPLSNDVALINSRSVTSLPPPSTIADRVHNSLPAALAASAPASGPTGNSTHLRSDNMEDGAELQSKVEMILREWIQLCYTPQAQKEPQQALAQIVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD69</accession>
    <name>A0A183HD69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tub domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5435</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004665">
        <property type="protein sequence ID" value="VDO43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD69"/>
    <dbReference type="STRING" id="387005.A0A183HD69"/>
    <dbReference type="WBParaSite" id="OFLC_0000543001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000543001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000543001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000543001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31223" checksum="1E56B291DE3F6498" modified="2016-09-07" version="1">MEEHLRQKRRLSSTNVRPNDTSLMLMAMARDYNKPYIYNGPLSYTSLDDPDRTSPTLASESIVGTVDFESTVPTAAYESTFSAVISKSTIATVASGSSVAPVTSGSTVATVMTSHCNESSSEENICKPTHNLTTTTSVPSSTMIENPDLNTIITNLEIFVTSPARRNVTYKCRITRDKKGVDRSIYPIYYLHLEKDDEKRIFLLAARRRKKSATANYLFSIDPTDLKRSGSSFIGKVRSNALGTQFTLYDNGENPKKSWVIGDSVRQELAAVIYVRMLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDB9</accession>
    <name>A0A183HDB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5481</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004734">
        <property type="protein sequence ID" value="VDO43303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDB9"/>
    <dbReference type="STRING" id="387005.A0A183HDB9"/>
    <dbReference type="WBParaSite" id="OFLC_0000548001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000548001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000548001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000548001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17381" checksum="9253404B394E55DF" modified="2016-09-07" version="1">MYFNCSVSDVNEINNCGAIVIPMQMLRSLSPEGVMLRIAISYPFLDAGSFIIVDSRRMFSFLSEKETNIIMVPVNTSIELTNLPLSLYTNAQYFDSLSQPPTFISNCVICDESFSSQEESDAHFVSEDHETAQVTAAHHTSRNNDYVGEYSEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE44</accession>
    <name>A0A183HE44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5758</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005119">
        <property type="protein sequence ID" value="VDO44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE44"/>
    <dbReference type="WBParaSite" id="OFLC_0000575501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000575501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000575501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000575501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18967" checksum="B2CF4E88AE5B7F69" modified="2016-09-07" version="1">MRTSHTLPKAISPFLQSFDNDEREERPITVTPKLRSTRRSTTITTTTTTTTTVMPIITTITVTSPTPYPILLSRLSSATHVDETKRDKVQARWRKLGPLVKSVQYPYSRRNWHRTVLTKDDSLEVSNRIKQIIKQRLQQQQQQKQQRRQQQQQQEQEQQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF96</accession>
    <name>A0A183HF96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6158</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005707">
        <property type="protein sequence ID" value="VDO45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF96"/>
    <dbReference type="STRING" id="387005.A0A183HF96"/>
    <dbReference type="WBParaSite" id="OFLC_0000615701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000615701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000615701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000615701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10837" checksum="F54EB00C9A9A45A2" modified="2016-09-07" version="1">MLSERQAYEIRKRYFAALLRQQMSWYDKNETGALTNKLSVGIEKIKHGIGDKFGALLQASAHFIVGVIIACYYRYFNAILHEIGARISINDPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFK0</accession>
    <name>A0A183HFK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005845">
        <property type="protein sequence ID" value="VDO45937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFK0"/>
    <dbReference type="STRING" id="387005.A0A183HFK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000626101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000626101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000626101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000626101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13181" checksum="EA52A3E945612E83" modified="2016-09-07" version="1">MMVDIVLGEDENSSPSSPELQNDAWLIEQARKMFLLCDHNGKGFVVKMDLARIDGMIPNISQQQLELFFDNADIFKTNYITENQFIDNISKFILYSDSVDMLQVKLIFLMQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG86</accession>
    <name>A0A183HG86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6499</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006205">
        <property type="protein sequence ID" value="VDO46740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG86"/>
    <dbReference type="STRING" id="387005.A0A183HG86"/>
    <dbReference type="WBParaSite" id="OFLC_0000649701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000649701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000649701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000649701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5241" checksum="05B41836D829FEBF" modified="2016-09-07" version="1">MSAQNTEDINEMVSWTKQLIKRIDTIQASVAAKDALSNSSKLRSQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHU1</accession>
    <name>A0A183HHU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad21_Rec8_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7057</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007114">
        <property type="protein sequence ID" value="VDO49113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHU1"/>
    <dbReference type="STRING" id="387005.A0A183HHU1"/>
    <dbReference type="WBParaSite" id="OFLC_0000705201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000705201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000705201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO49113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000705201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18454" checksum="35543AD74B923A36" modified="2016-09-07" version="1">MFYAQFVLSKKGPLAKIWLAAHWEKKLSKAQIYETNVQDAVDEILKPKVKMALRTTGHLLLGIVRIYSRKAKYLLADCNEAFLKIKMAFRPGQVELDEDGQQAAIAAINLPEVFHDFDAALPDFNELDLHTQIHINQSRIDDITLKEDLIPEATDMPFGGEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHZ4</accession>
    <name>A0A183HHZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7106</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007188">
        <property type="protein sequence ID" value="VDO49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000710501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000710501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000710501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000710501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14101" checksum="123BD672738C03DA" modified="2016-09-07" version="1">MEDDLDLLAPSEQNVTTNQKIRDPYISAKHITDKNQSKLTKIIKSRSESGMDIKCNSQELKELMLENISDNSSVSKRAINDRAEAKFGGSIDVICSKGHFSYVYSSNLYCEAMKGNVTCIAFRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI15</accession>
    <name>A0A183HI15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7128</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007228">
        <property type="protein sequence ID" value="VDO49458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI15"/>
    <dbReference type="STRING" id="387005.A0A183HI15"/>
    <dbReference type="WBParaSite" id="OFLC_0000712601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000712601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000712601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="5 6">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO49458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000712601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27371" checksum="0EDED327F8FE816E" modified="2016-09-07" version="1">MLTIYFEIQGRFCENRCQKGFYGINCASKCFCYNENECDPVTGNCHCIGFTGKHCENPCPDGTFGEEVTRCHPMNGTCICLEGFQGERCDEKICPFDRFGPNCENECACNRKNTKLCHPTIGFCSCHAGYTGAGCNSPCPTSYYGENCEKKCECNLNTGSQCDPVTGQCICAAGYQGIRYGLTVLLIFEYLIRFTCDEKCPEGLFGMNCESKCNCKNGASCDHRFGTCNCTAGRLLSFTILRLFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI75</accession>
    <name>A0A183HI75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycos_transf_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7189</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007331">
        <property type="protein sequence ID" value="VDO49737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI75"/>
    <dbReference type="STRING" id="387005.A0A183HI75"/>
    <dbReference type="WBParaSite" id="OFLC_0000718601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000718601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000718601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO49737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000718601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27698" checksum="FC8B294F204B548C" modified="2016-09-07" version="1">WTRNHIVALWDTDDRTYLVYPPCNVDNLLRINSRAEKLLTEERRVQMLSIGQIRPEKDHRLQICFLAELKKRLLKENLDYKIRLVICGGCRDMDDVQRAKDLQLYAEDMGLSTDDLEWALNAPVDKVAALLEESLIGIHTMQNEHFGISVVEGIAAGQIMIAHNSGGPKLDILNANAVGSKTSLGLLAVSVHDFVDSVLEIIRMSPEERNSIRDAARCSVNRFTETNFEKRWNTVIKKLLPAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIP0</accession>
    <name>A0A183HIP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carn_acyltransf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7353</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007628">
        <property type="protein sequence ID" value="VDO50595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIP0"/>
    <dbReference type="STRING" id="387005.A0A183HIP0"/>
    <dbReference type="WBParaSite" id="OFLC_0000735101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000735101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000735101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="50"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO50595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000735101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31348" checksum="739F9D04E0F3A898" modified="2016-09-07" version="1">MQASCRGISLIRLRRISTSCIAQKLKGDDYQYVHKSDIPTYHFQQSLRRLPIPKLSDSCRRLIGAAEAILRKEELESLKELVEDFKAHEGPKLQRELILHDKRNLHTSYISEPWFDMYLSDRIPCPINYNPFMVYAPDPDPAYNDQLTRATNLIISYGRIKRALDSEYLKPEIYYLNPKTATSKPFNWLCKNLSKNLRWYGAAAFGAFPLDMSQYKSLFGGSRIPQKGKDWLLHCADSKHFIVLHGGRIYSVDLFDKHGMLLIEMSSSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIQ0</accession>
    <name>A0A183HIQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007638">
        <property type="protein sequence ID" value="VDO50625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000736101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000736101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000736101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000736101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28272" checksum="034EA0171E2A8E32" modified="2016-09-07" version="1">MVVIQDDLEVPLALIANHELVAVPRQVFPVEEVTAAFMAKKTSVTTDVEWPEFTTIGRSIEGRILNAPPWIREFTNPAVKKIALSVQRFGRDREGFAVIKEHIGRGVILTPIDEEDKKICGDLFFPYEMRTDASCTMRKYEDIYRLGSKWYFRACPELPNRKYKYRVYSLNSLNDVISGTCTMRERFPEQILNPSIATNHEPVVDISTNAVSSTSHQPDDSNQLIDFDNEPLSVGLIDYIDHSSRTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJQ9</accession>
    <name>A0A183HJQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NPH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008239">
        <property type="protein sequence ID" value="VDO52299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJQ9"/>
    <dbReference type="STRING" id="387005.A0A183HJQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000772001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000772001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000772001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000772001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14081" checksum="FBAD5C4E6657A6B2" modified="2016-09-07" version="1">MGESDRLSSSDIRGFLKVSMNVRRSLDPTPAPSLRSTVLHEDDDILFSGSLMHYTMLIRIFQLCEIADHLRMHNDDVAKLALQVQIGKESEMTHVLQALYEVIDINEEIMLPVVWPTVVKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKB1</accession>
    <name>A0A183HKB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N2,N2-dimethylguanosine tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7922</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008594">
        <property type="protein sequence ID" value="VDO53147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKB1"/>
    <dbReference type="STRING" id="387005.A0A183HKB1"/>
    <dbReference type="WBParaSite" id="OFLC_0000792201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000792201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000792201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000792201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9483" checksum="4D379FA01B609BC3" modified="2016-09-07" version="1">MLIQYKTNDTGDYISAHHYLFEGCMVLELGAGCTGIPGLVAAKCGAELVIFTDHPENEEAFKILEQNCIGNDLDKNSFLIRVSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKC6</accession>
    <name>A0A183HKC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotran_1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008634">
        <property type="protein sequence ID" value="VDO53269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKC6"/>
    <dbReference type="STRING" id="387005.A0A183HKC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000793701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000793701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000793701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000793701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7627" checksum="61328A0021DA476C" modified="2016-09-07" version="1">MLKRRVGIVVVSFPATSITESRIRICLSAAHTKEMLNFVLDAIKEVAEASNILSSRIKQKNANLEIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLJ9</accession>
    <name>A0A183HLJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8363</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009392">
        <property type="protein sequence ID" value="VDO55301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000836001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000836001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000836001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000836001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3570" checksum="C86167A606E46050" modified="2016-09-07" version="1">MSSFSTNVPRSPGGDGCPEKMSTHSETSMSSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM15</accession>
    <name>A0A183HM15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009718">
        <property type="protein sequence ID" value="VDO56113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM15"/>
    <dbReference type="STRING" id="387005.A0A183HM15"/>
    <dbReference type="WBParaSite" id="OFLC_0000852601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000852601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000852601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B-box C-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000852601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22335" checksum="6CE83A834D0F6D18" modified="2016-09-07" version="1">MECTQVDHVQPAHQYELISDVADKQMAIMETLVQDARLKHSELLETYKMVDAAQNRLSCSLTRAHQNVDDATQTLIRIIEDNRRQIIKDLDNAYGAKQLQLTVIDKKVQQMAEKLAQTIEFTSRLVKYAAPTEVMVFKQLLHTRLQVYFSFNPDSNNILQTACELDFPPLNPNVARQQIISIMGVFIFFLRIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMP4</accession>
    <name>A0A183HMP4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large subunit GTPase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8755</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010157">
        <property type="protein sequence ID" value="VDO57235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMP4"/>
    <dbReference type="STRING" id="387005.A0A183HMP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000875501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000875501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000875501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="61"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO57235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000875501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34816" checksum="B03C211E326553F3" modified="2016-09-07" version="1">YRKYGDRLRIPRRPPKYAWETVDDLIRLENEYFLEWRKNLADLQEGHGVLLTPYERNLELWRQLWRVIERSDIIIQILDARNPLLFRNLDLETYVKECDVAKQNIYLINKVDLLSKEQIESWRKWFLENNIDAIFWSALEPKASSINEKVMKEMSQSDGSESSGSSDENEKKVEKKRQDSEESSSDTNEDDDSNKSENSSEAKLWQNKEKVPIIHCAAELISFLKSRGHVQTGDMERCPLVVGMVGYPNVGKSSTINKLLDQKKVSVSATPGKTRHLQTLIVDDEVFYNFGNKLKISTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMX7</accession>
    <name>A0A183HMX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane 9 superfamily member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8838</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010323">
        <property type="protein sequence ID" value="VDO57659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMX7"/>
    <dbReference type="WBParaSite" id="OFLC_0000883801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000883801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000883801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000883801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11593" checksum="C5945021E598A9B8" modified="2016-09-07" version="1">MMVGLFGVVVVGFLLGFSWYRVKWIYQFTEDRQDISHFAACFLIGSTTVLSFTFYALPPYRGRERGMYMQVLYLPGAENKIRVSLLKTINYIAMWGFPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNE8</accession>
    <name>A0A183HNE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010650">
        <property type="protein sequence ID" value="VDO58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNE8"/>
    <dbReference type="WBParaSite" id="OFLC_0000900901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000900901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000900901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000900901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14806" checksum="F7B18F6EC15E786D" modified="2016-09-07" version="1">MSIADSLEMKVTLLFRDRTTVCIPLYSNNYQPFTSALLLGLKDAEAMVKFVRGVKAEVKFSNLKIMFAENFEHFIEKSWNNGQEVTLTNFIFFPLGDCKIVVKSSKREEYKRIASVQCSMKSLIFDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNG6</accession>
    <name>A0A183HNG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9027</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010681">
        <property type="protein sequence ID" value="VDO58421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNG6"/>
    <dbReference type="STRING" id="387005.A0A183HNG6"/>
    <dbReference type="WBParaSite" id="OFLC_0000902701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000902701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000902701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO58421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000902701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19127" checksum="CEC78DE6C23CB0CA" modified="2016-09-07" version="1">MLCILIVSSEKLKFIIITVYFSGIAYAVLAGADPVYGLYTSFFPVFFYMFFGTSKHASIGTFAVISIMAAVASNEIIQELKMSNTIVMNNTVISLTYVEVTTTLAFTIGIVELAAGIFQLEFVTAYFSDTLVSGFITAAAIHVVYAQLDGFFGFTAPKFNGIGYLFKVFDGIINSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNN7</accession>
    <name>A0A183HNN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_S9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010813">
        <property type="protein sequence ID" value="VDO58703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNN7"/>
    <dbReference type="STRING" id="387005.A0A183HNN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000909801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000909801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000909801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000909801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12121" checksum="8D72C40B00733EE2" modified="2016-09-07" version="1">MSGMRVAFPGTQRTWCCDAFPSIDKVARVRCPTLVIHGTDDEVIDFSHGVSIYEHCPSSVEPLWVPGAGHNDVELHAAYLDRLRAFIENEAYGGKESSITTTATSAASHVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQJ7</accession>
    <name>A0A183HQJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012309">
        <property type="protein sequence ID" value="VDO63009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQJ7"/>
    <dbReference type="STRING" id="387005.A0A183HQJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000975801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000975801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000975801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000975801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11409" checksum="A331C84DEDE181B1" modified="2016-09-07" version="1">MHEKNETKKAELFKRLDTNDIIPFLDRYEWFLRNSPTGYFVGKKISLADLAVFNMLNILDGQIKLNKYPKLAKFFGQIGQMPQIKQWIDTRPQTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQZ8</accession>
    <name>A0A183HQZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012664">
        <property type="protein sequence ID" value="VDO64379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQZ8"/>
    <dbReference type="STRING" id="387005.A0A183HQZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000990901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000990901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000990901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000990901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8084" checksum="FC95FCCA7F60878F" modified="2016-09-07" version="1">MACGIALKRPYDYDDYLIAEGSEAKRARHTQTHCSPFRAQIGTIAASLPTSGASSALMQLRDPKVISFYSFCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRN7</accession>
    <name>A0A183HRN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013236">
        <property type="protein sequence ID" value="VDO66217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRN7"/>
    <dbReference type="WBParaSite" id="OFLC_0001014801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001014801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001014801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001014801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15146" checksum="AEC9B66D37523E21" modified="2016-09-07" version="1">MTFVCNGEIFIQVYQSECGNTPDHLPDPCKPDPDDFYFSCSHVGNILNGQISAEDRETIPNRTASRCALVGPSPYREILDRSQQLRYTYGYLEDIALMHLQDKGNNVLIIDGMQMIPPSESETFDTTTADSDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRZ4</accession>
    <name>A0A183HRZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10254</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013469">
        <property type="protein sequence ID" value="VDO67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRZ4"/>
    <dbReference type="STRING" id="387005.A0A183HRZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001025501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001025501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001025501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001025501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13716" checksum="A6DD66B95618DD44" modified="2016-09-07" version="1">MKWAINRIKYLSGATNTGAALKFVLERGFQDARGGEIPKVAVVVTDGQSQDSVAEEAQRLRDAHVMLYAIGVTNLVNVHQLHQIAGNPSRVLTVESFDELSRNLADSLTWDMCKTEFSTFVVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSN2</accession>
    <name>A0A183HSN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10494</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014044">
        <property type="protein sequence ID" value="VDO68928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSN2"/>
    <dbReference type="STRING" id="387005.A0A183HSN2"/>
    <dbReference type="WBParaSite" id="OFLC_0001049301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001049301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001049301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001049301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16500" checksum="5DBE6356E63C4D9A" modified="2016-09-07" version="1">MIRNVELDALQQKFASRMRIMEDTNKSLHSQLVQARRDRDYHREALHTFESKVSEEQRRGESDVKRFEELERKNIDMTKQVEDLKAEVTKLNSDLKLAKEIHEADRALWEVEKSHLKPVMADTNIDNKTIDDAKNVKVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT38</accession>
    <name>A0A183HT38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014418">
        <property type="protein sequence ID" value="VDO70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT38"/>
    <dbReference type="STRING" id="387005.A0A183HT38"/>
    <dbReference type="WBParaSite" id="OFLC_0001065001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001065001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001065001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001065001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="5828" checksum="F6AF6A6CDCCD1510" modified="2016-09-07" version="1">MFDTDPADCSRGPIAVGHCVIGPMCPGAGCAHWLQMIRKTGLPICMWHRLFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTB8</accession>
    <name>A0A183HTB8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="1">ETF-QO</shortName>
            <ecNumber evidence="1">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01014642">
        <property type="protein sequence ID" value="VDO70891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTB8"/>
    <dbReference type="STRING" id="387005.A0A183HTB8"/>
    <dbReference type="WBParaSite" id="OFLC_0001073001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001073001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001073001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001073001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15207" checksum="E353DA4C8E690173" modified="2016-09-07" version="1">WICDFSDIRVCVVEKGAEVGAHTLSGAVIDVRALSELFPNWQELDAPVHQKVTSQSMAILTRKGRYALPFVRGSPLDNMGNYIVRLGHLVKWLGEKATEMGVEIYPGIAAQEILFHDDESVKGIATTDVGIMKDGAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTD1</accession>
    <name>A0A183HTD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxypeptidase-like regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10742</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014665">
        <property type="protein sequence ID" value="VDO70969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTD1"/>
    <dbReference type="STRING" id="387005.A0A183HTD1"/>
    <dbReference type="WBParaSite" id="OFLC_0001074301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001074301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001074301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin TTR-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO70969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001074301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15735" checksum="38F66F84A6FB3222" modified="2016-09-07" version="1">FQFFFFFFQQIKFLVQRDSVQRYADERYFNESFVSVIRGRVLAENGSPITGVRIAEARHPTLTGFTLSRSEDNGGAFDLVVNGGKTVTLQFMRKPFEKLEKSFYIRWNEIIYVGDIKMLLGQQVGSYFTELSKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTE1</accession>
    <name>A0A183HTE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014699">
        <property type="protein sequence ID" value="VDO71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTE1"/>
    <dbReference type="STRING" id="387005.A0A183HTE1"/>
    <dbReference type="WBParaSite" id="OFLC_0001075301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001075301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001075301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001075301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13905" checksum="BFA63D3F03DAAE3A" modified="2016-09-07" version="1">MYNRFDTGLLPRENTNDVTLSTMEHVSILEAHLTSLQSRLAELKLLVEKQQTPGSEVMSDSGHYSCISSTVTSETSKISDVVSSTSNYMMEGKEKKLSLNDSEKQNIQENGIYDVSFPYSVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTJ7</accession>
    <name>A0A183HTJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zf-C3H1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014859">
        <property type="protein sequence ID" value="VDO71539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTJ7"/>
    <dbReference type="STRING" id="387005.A0A183HTJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001080901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001080901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001080901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001080901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15575" checksum="44BFC478522FE72B" modified="2016-09-07" version="1">MSDDKFDEGGISPTYPYHLIAHRALSNKLDPLKPLCYYELLGRCADATCSMQHEEDYLLSDEELICSVLAYCPNLCPPKKMFSEYAREILKENEGKPVGEIIEDMLKSLPDNERRIRICEMATKCRQPSKLPTETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTX7</accession>
    <name>A0A183HTX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10936</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015183">
        <property type="protein sequence ID" value="VDO72524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTX7"/>
    <dbReference type="STRING" id="387005.A0A183HTX7"/>
    <dbReference type="WBParaSite" id="OFLC_0001093901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001093901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001093901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001093901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11723" checksum="08445CBF254FC202" modified="2016-09-07" version="1">MKYNWYLIPIYDWGSRSHVSGKIDSEDLNSKIEVNVEEPIDNQLCNSEIRQIQAGRVVPTHVFAVRGNRIYRIDRSGGSTTTTPVRTLSETNRGVAVIVSSVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU14</accession>
    <name>A0A183HU14_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS10977</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01015276">
        <property type="protein sequence ID" value="VDO72827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU14"/>
    <dbReference type="STRING" id="387005.A0A183HU14"/>
    <dbReference type="WBParaSite" id="OFLC_0001097601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001097601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001097601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO72827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001097601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12613" checksum="0709AA0081FD9A9D" modified="2016-09-07" version="1">MLVALFTTNLIGICVARSLHYQFYSWYFYTLPYLLFAGLPFSNDWFFTGGATSTQKSTGAVSPLSIILRCSILVGIEICWNTYPSTVVSSAMLHWDLGMTNCLCHISMHSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV38</accession>
    <name>A0A183HV38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11351</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016310">
        <property type="protein sequence ID" value="VDO75831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV38"/>
    <dbReference type="WBParaSite" id="OFLC_0001135001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001135001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001135001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001135001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14090" checksum="04ECC7B5DEE84DE4" modified="2016-09-07" version="1">YFSFHDGIFQISYIGTAEQSQQQNLQYLYRNNALANCQSDELTFGFTSIRSNECYDLTDFNKNCNHKSPNFLQQQPIYSKYGDDIMYNGTNQYLANEPSSIDHPKSQIISDIPIFNSSDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVT8</accession>
    <name>A0A183HVT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016968">
        <property type="protein sequence ID" value="VDO77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVT8"/>
    <dbReference type="WBParaSite" id="OFLC_0001160001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001160001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001160001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001160001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7260" checksum="800A38CBA5491220" modified="2016-09-07" version="1">MEAKMAHESNTMKHQAILGEVETDKLCLDGWDVSPAGHCVGNISLKSYASFFFFGYFFCFELLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWT1</accession>
    <name>A0A183HWT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TGFb_propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11947</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017912">
        <property type="protein sequence ID" value="VDO80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWT1"/>
    <dbReference type="STRING" id="387005.A0A183HWT1"/>
    <dbReference type="WBParaSite" id="OFLC_0001194301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001194301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001194301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552656" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001194301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22124" checksum="A17FD943D9A149CB" modified="2016-09-07" version="1">MLLLAASIHSIFLALSLFSSSQSTTTYGTAVWRHLSNNNNNNYSCHGCAEARDELAKIRLEIIKREILEKLGLDAPPQVRPQDGFPTIPQVAKYLKYQLRHDSAAASLQHTSFLADELMMPERKAERTIVLAEQIPAHFNLNPNQVFAHFKFSDELMSKLLLSTVLNIYLQKSTKLHPDSRIAAVQVLVKEVIKNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX83</accession>
    <name>A0A183HX83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TAXi_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12095</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018332">
        <property type="protein sequence ID" value="VDO81878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX83"/>
    <dbReference type="STRING" id="387005.A0A183HX83"/>
    <dbReference type="WBParaSite" id="OFLC_0001209501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001209501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001209501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF276">
        <property type="entry name" value="DEGENERIN DEG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001209501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14098" checksum="73EA24A6D95CCC2B" modified="2016-09-07" version="1">DADFKLHVDPEFGNCYTFNWDKNNNHTSSKAGPMYGIRLLLFVNTSDYMTTSESAGIRLAVHSPTDFPFPDTFGYSAPVGFASSFGLKKHVVQRLSAPYGDCQRKKKMNSSVYIYGDYDYNPEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXF9</accession>
    <name>A0A183HXF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Holliday junction resolvase RecU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12172</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018551">
        <property type="protein sequence ID" value="VDO82507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXF9"/>
    <dbReference type="STRING" id="387005.A0A183HXF9"/>
    <dbReference type="WBParaSite" id="OFLC_0001217101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001217101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001217101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF91">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001217101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13652" checksum="17E165A0BA0B3B1D" modified="2016-09-07" version="1">MGMEQGLDYDKLLIKTDPVVRTIATELELFHGGDQIDIAVVKAPDMTKPMNRKRVEQMIHDFEHMIFGIGPKATQVWIREYQKYANITGAYLQNDHQSWVEGVYQWSRLFAFYKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXH1</accession>
    <name>A0A183HXH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12184</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018583">
        <property type="protein sequence ID" value="VDO82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXH1"/>
    <dbReference type="WBParaSite" id="OFLC_0001218301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001218301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001218301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001218301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11886" checksum="09C54BC2AAE0EC53" modified="2016-09-07" version="1">MDDPDVIRTRNLLIWSQTRYRCATESTLTAFMFSSVRDGYYSEQRRIRKTSQTNRSKISLIDPPDEMLNPALENKRNSGGILDESRKVTTKVKESQNNDTLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXN3</accession>
    <name>A0A183HXN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018770">
        <property type="protein sequence ID" value="VDO83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXN3"/>
    <dbReference type="WBParaSite" id="OFLC_0001224601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001224601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001224601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001224601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7820" checksum="E7AD4544DD9B17DC" modified="2016-09-07" version="1">MLEAVKATISKVSYDWGSLSLCIQCIHALVNEVRMKKTALSNMEQLGTINKTRKKLDKKEQAEVYLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY98</accession>
    <name>A0A183HY98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039848">
        <property type="protein sequence ID" value="VDP11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY98"/>
    <dbReference type="WBParaSite" id="OFLC_0001246101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001246101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001246101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001246101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13943" checksum="39A6464BA65E7013" modified="2016-09-07" version="1">MHIANIKDNCKEWNAKNACREEQSGSASHMYPIHVLHGRHLVHSISSWLHSNPTHHCVSLLRTLSIRRRGLSCEIETMSGHMVSVDLTADTNSRKLGVFHAFHRLIFRIEFYESSIIRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYC5</accession>
    <name>A0A183HYC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12487</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039853">
        <property type="protein sequence ID" value="VDP11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYC5"/>
    <dbReference type="STRING" id="387005.A0A183HYC5"/>
    <dbReference type="WBParaSite" id="OFLC_0001248801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001248801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001248801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001248801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15538" checksum="2ED085A974C5824D" modified="2016-09-07" version="1">MFAAWSLITEKIAITADDSDYDYLNNDLDENQKPADIFWGDVLDDEQQKEINDSFGGNDVQRRNCSTETAIIDKLLNVSRKNLKLEGKINSNYCSSTRTKSIGVKNREKGKDEKNTLGAVDSEFIVLVYLKSPIQVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I013</accession>
    <name>A0A183I013_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">OFLC_LOCUS13075</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040035">
        <property type="protein sequence ID" value="VDP12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I013"/>
    <dbReference type="STRING" id="387005.A0A183I013"/>
    <dbReference type="WBParaSite" id="OFLC_0001307601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001307601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001307601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001307601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="49312" checksum="3B3752DC354F4A83" modified="2016-09-07" version="1">MIGVIAPYLLKFQRSYQSNDIIDRLNYQYTAQIIALTAFTLAATQYVGKPIQCWVPAQFTGAWEKYTETYCFIKGSYHKPLDSEISQEYSQRDESVIEYYQWVPIILAFQAFLFYFPSIVWRTMNFHAGINVKGILNSAAMVKKKFDKSSRLAQVHIAADHLRDALDMQRELRTGSLDCLRRGKRSGIYLISLYLFTKVLYVVNVILQFVIMNAFLGPQYTFWGAGILSDIWSGKEWSESGHFPRVTMCDFHIRVLGNIHRWTVQCVLMINMFNEKVYIFLWWWFILIGILSILSLLYYFFALVLGSNQRQFVIRYLRCAGAIPDSRDPKTEKYLHDFIKRFLRPDGVFILRLIEVWLISKTDRHTVLMIRRLSLQTNGGDLLVGEIVNVMFARYKSRMEEQSETMAVTDGTHLNGSDSLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I049</accession>
    <name>A0A183I049_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13111</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040050">
        <property type="protein sequence ID" value="VDP12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I049"/>
    <dbReference type="WBParaSite" id="OFLC_0001311201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001311201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001311201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001311201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12794" checksum="C5EB8DB2A9F49483" modified="2016-09-07" version="1">MKRNGEVEILFQKSEIHYGIHGEARRYHPNEDLCLCALLCSKAYKRSRLAEMKCHWNAPKNAFVALVHACMHHSARMLLHDRMGDLLQGTTFSHINFESDNVEMIADCHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0G4</accession>
    <name>A0A183I0G4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13226</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040098">
        <property type="protein sequence ID" value="VDP13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0G4"/>
    <dbReference type="WBParaSite" id="OFLC_0001322701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001322701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001322701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17098">
        <property type="entry name" value="FERM_F1_FARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1195"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001322701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1283" mass="143598" checksum="0B33B806711F0B23" modified="2016-09-07" version="1">MKVWSDMGGPGSGMIPKGVGAPPPPGMDNRRGKLMCIKVRMLDDSVGVFHLGHKALGQALFDEVCRHLNLLECDYFSLEFTDCYGNRCWLDKDKPILRQITTTHSDARFYFIVKFYTPNPADLVEEYTRYLFALQIKRDLATGELICNENTAALLASYIVQSDCGDFAAEDYPDDSYLSSARFIPNQSSAFQKKVMENHKKLIGMSPGESDLTLLETARRCDYYGVKLHAAKDVEGTEISLTIAHMGIRVFHQFQCVSTFSWAKIRKLSFKRRKLLIKLHPESHQYYKETIEFLFESRNECKNFWKKCVEHHTFFRCIEVLPMKRTREGRLFSKGSAFRYQGRTQKQLIDYIREHRKRREPFTRPIKLGLSSSTNGRLSRPAYFETNYPAYATVSERSVNLVGSGTLPSRNVPVYCMNGERSINRGPYISKQRHGQGTGQQPVTTGTMSYFPGEIPMNKYGTTASIRNHRHRYSQNYPSNSSAAAVNGERMCLSDMESNDVCSLAGGGTMNSRYRQQQSDFRPLKSSTVKYVKTGAIAVPGNSGNITDTSDNDAITSVSLPNVLGDDVQIVCREFELKCECPPKSASGDNFLELHQPPRDYDNISEGSYKLSDNELRSAHSDIQPVPINPVYATTFTAKRVGNVIVKKVVSNTRSTPNTTDDEDPYSERRLDSGRRKTEIERNQQRTLEHVYRQESSASNQVEIDDANSQRRFCVEKKHSSSAPASYAEYPLHQKLVPIEIDGPNVNLDEHRKLSNKKEMNRIAKVRGNAPPQTPIRAPVTKIESDRWPITTEPQPSISCTNEAQQKHSKIVYTSKGTILQRPKIIPDEDDLSGSENIYSNVSLTHASDNSQSHMTIAEPQQAPKTYGAIRPLPGKIITKENLIITPEGYRERKPKPVVPPKPKNLAYTSETGSTESTSICAAPESKPNHPVVNLQKEGIFPSYTVAPSMPEMNRPALISVQSEDHPEIQQCHLFNSDIPYVLTMRNLSTEAEGSFSTFKDTSSKNTVSEALASTMESGKLHRSLSGSQSPERLKRRKSLDLVPKKRLPSPGNFSSQDHSLSSSTPESGDVLEYLLRKRSVERSSIAKRGCRGDPRRQTQPVRFNIPSSSKTEEQQIGAVSQPNLNDNTEYVMENNGRQERVTKDSGENDRVNSDFKTESERSLETQKKKEEHSKNNGPVIIGNELTDSTNVDDFPPPPPPPPPPPPPPPSIPIVLKHSASPEASQPVTEACMQESVETLPYADESASSRTSCASKDESTDKISSSVPSSTLRTPTGVLWTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I181</accession>
    <name>A0A183I181_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13493</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040230">
        <property type="protein sequence ID" value="VDP13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I181"/>
    <dbReference type="STRING" id="387005.A0A183I181"/>
    <dbReference type="WBParaSite" id="OFLC_0001349401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001349401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001349401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001349401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10028" checksum="42ADE05A08890DAE" modified="2016-09-07" version="1">MYYTKSENMNFILFPKASSINKRIKMIELQSRIKAYKLIGYSAFFFSFLAILSICITLPMVYNYVHHVRQKMISDIEFCKVSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1N7</accession>
    <name>A0A183I1N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI/MSF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040315">
        <property type="protein sequence ID" value="VDP14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1N7"/>
    <dbReference type="STRING" id="387005.A0A183I1N7"/>
    <dbReference type="WBParaSite" id="OFLC_0001365001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001365001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001365001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001365001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12520" checksum="D2D57B4A22B7C1A1" modified="2016-09-07" version="1">MICLVPFGQKIEVDVYKTRQIGVKTRTYVNVGNIMCYFVYKKRKMYRNETLQLEGDSIWGSITLLLSSLTGRPCTGPERAQFYEDILLKSLEKQEKAMLSLLKFSEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Q6</accession>
    <name>A0A183I2Q6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14018</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040539">
        <property type="protein sequence ID" value="VDP15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Q6"/>
    <dbReference type="STRING" id="387005.A0A183I2Q6"/>
    <dbReference type="WBParaSite" id="OFLC_0001402601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001402601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001402601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001402601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10690" checksum="9198E3618E2A1DF7" modified="2016-09-07" version="1">MEEIADKNIIIARSFENAITLLQSMENIETVWNIGGRALYITRVEGDFSADVFFPEVDYSRFIKNTESEEVHEENNIKYKYEVYTIKTDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Q5</accession>
    <name>A0A183I3Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14367</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040797">
        <property type="protein sequence ID" value="VDP16732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Q5"/>
    <dbReference type="STRING" id="387005.A0A183I3Q5"/>
    <dbReference type="WBParaSite" id="OFLC_0001437501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001437501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001437501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001437501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26330" checksum="0F658F1FBAD81453" modified="2016-09-07" version="1">MTMFNNCYTYNPPEYGVYMMAKNLEQYILTKLAAMPPEDFESIFSNCYKFNQNEDDVSLMCKNVENLYREKMKLLPSQEVEIPRPTAKRAAGKSKKSTGRVAIVKGGSRESSVSVQRGAADSSSILDAAANGAIHASASAAVDDVHPTSSQAPVQPVLPSKVQKGVKRKADTTTSFGDDIVSAKIATRRESGRPPKKPNYFIDYNQLKPRFKGKQTEQMKFCQRLVNELFTKVLKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Y3</accession>
    <name>A0A183I3Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome activator complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14445</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040863">
        <property type="protein sequence ID" value="VDP17076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Y3"/>
    <dbReference type="STRING" id="387005.A0A183I3Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0001445301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001445301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001445301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000001">
        <property type="entry name" value="Proteasome activator complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.120">
        <property type="entry name" value="Proteasome activator pa28, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036996">
        <property type="entry name" value="PA28_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003185">
        <property type="entry name" value="Proteasome_activ_PA28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02251">
        <property type="entry name" value="PA28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="4">
        <location>
            <begin position="113"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP17076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001445301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30070" checksum="2B490A110F9845C9" modified="2016-09-07" version="1">MEMRIIRGKLDAYKTNLMKQAEKIVLEEFPKKVLEFNNLLEGEQFSYERLPELLPNIDLGIPYAEQLIEYANDRNSTEHENDDGVLKKKRRIDHANIQPLHGTSVYGFINGTVKCNEKLASLTDVTRPLLRDSVEAVNKVKMWILFLIPRIEDGNNFGVSIQEEALNEVRTVEGEAASFLDQMSRYFVSRARLVTKVAKYPHVEDYRRAILDMDEKQFINIRLVLTEMRNHFATLHDMITKNLEKIKTPRSNNTEHMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5G8</accession>
    <name>A0A183I5G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14980</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041441">
        <property type="protein sequence ID" value="VDP19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5G8"/>
    <dbReference type="STRING" id="387005.A0A183I5G8"/>
    <dbReference type="WBParaSite" id="OFLC_0001499101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001499101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001499101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001499101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34798" checksum="0759E761B677B6A8" modified="2016-09-07" version="1">MDTRSDWTGSNIQPFEEEPIMVESNVTVGVACRLGNVELTQQLLHAGYGSYPDDRSWWPIHEAAYGLHLECCKLLIENGRCNVNAQAHDSVTPLMLVCRMSYRHNEAIEVARYLLNNGANPNARTLDEMTPLIQAIKSKNTFLALLLIDKGANPLDVWYDGWSALHESANTKDLVMMQKLIDLGADIFAIDTSKHTALMVAVQENFYHGVKLLLEVAGDRAAELANISVENGLTCVMAAADAGFADILLLLINHGADCNITQHPVWGDDGSRIHAIAVAALNNHPECVKLLIPHVDKEILKETEVSLDLSLSCFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5N5</accession>
    <name>A0A183I5N5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15047</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041539">
        <property type="protein sequence ID" value="VDP20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5N5"/>
    <dbReference type="STRING" id="387005.A0A183I5N5"/>
    <dbReference type="WBParaSite" id="OFLC_0001505801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001505801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001505801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001505801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17326" checksum="B5A0C2958DD22F4C" modified="2016-09-07" version="1">MTLNEKTYFSRETIVRGSQHHTDSEMSSSEEVSWITWFCGLRGNEFFCEVDEEYIQDKFNLTGLNEQVPHYRQALDMILDLEPDDDFEDNPNQSDLVEQAAEMLYGLIHARYILTNRGIQQMIDKWHDHDFGVCPRVYCENQPMLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I673</accession>
    <name>A0A183I673_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041809">
        <property type="protein sequence ID" value="VDP20952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I673"/>
    <dbReference type="WBParaSite" id="OFLC_0001524601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001524601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001524601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001524601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33995" checksum="00CA749772FE70D3" modified="2016-09-07" version="1">MNEVDHSTNEQQMSHGNAYIEESDIPGFAYDSVTKRYYKVQPQSSGPNIGFRESDLRGNRQHYSFMADRERCCARSCPSVSWLPKMIQRREIYNSNISQFARLVAERTLRAVRKDPSYIQRGYTDIEMLHSCHYVDISDDGKTIVGCWSVRRRRDERWSNSCGARLICFKVTAGHHDRRYVVXXXXARLICFKVTAGHHDRRENEYWNNFGLKIRSSTYGANLMKSNLVDMCVEPVNDNVTCALYVTTQTIVTMHNQFSTLSRVCIEPVAEFSSVYDSAELRLPSYNMRWTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V7</accession>
    <name>A0A183I6V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042196">
        <property type="protein sequence ID" value="VDP22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V7"/>
    <dbReference type="WBParaSite" id="OFLC_0001548001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001548001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001548001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001548001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8594" checksum="ECFF9AFB9B2AE27A" modified="2016-09-07" version="1">MDGTMSSRNIRGKDYDKTTYYYITSIISRKTCMDTHVHIPGHVTYARHSMVNRVPIQYARAISHCNRSGTNSSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7D0</accession>
    <name>A0A183I7D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15642</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042526">
        <property type="protein sequence ID" value="VDP23012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7D0"/>
    <dbReference type="STRING" id="387005.A0A183I7D0"/>
    <dbReference type="WBParaSite" id="OFLC_0001565501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001565501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001565501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001565501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17508" checksum="CBFF516848D343FC" modified="2016-09-07" version="1">MDLVFRKKWDTNVEKLELLRKDDDTDSELIHWIAKFPYPMYPREYVFVRRRYINKKDRCIVIANYAVTDSADIIPRCEKKYVRVKSYRSIMVVRAHKAFDCKGFDYVLSYYDNPESNIPKYAYNWLINYGGPYYLHQVITIKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7L2</accession>
    <name>A0A183I7L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042720">
        <property type="protein sequence ID" value="VDP23484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7L2"/>
    <dbReference type="WBParaSite" id="OFLC_0001573701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001573701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001573701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001573701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5823" checksum="79580B8EC1079F8F" modified="2016-09-07" version="1">MKEAVKKEIGEPRKLSKIRFQALNQYPLIDTSSRSLQRLSNHKNKKKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I880</accession>
    <name>A0A183I880_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15942</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043323">
        <property type="protein sequence ID" value="VDP25201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I880"/>
    <dbReference type="STRING" id="387005.A0A183I880"/>
    <dbReference type="WBParaSite" id="OFLC_0001595501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001595501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001595501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP25201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001595501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18565" checksum="FAB75B12F9586412" modified="2016-09-07" version="1">MLINRGANPNSATKQFMTSLHICAQVNALSCAEVILDHCDSIVDRPDWGGCPPFHYAAYYGNPAFVEFLLKKKANPNTKNKRGMTATHWAALNGHCNIIKLLFNNGVDLKLRDQETRTVLHYAALSGDLDSVKFILENTSIPIDSQCSAGYTPLHYAVLNGRSRVAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8F0</accession>
    <name>A0A183I8F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043594">
        <property type="protein sequence ID" value="VDP25977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8F0"/>
    <dbReference type="WBParaSite" id="OFLC_0001602501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001602501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001602501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001602501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6648" checksum="61FF9F2B2B869A72" modified="2016-09-07" version="1">MTRKFVKRSKFFAEFGNYIELQLARDMCGLRDFSLYRKYRFITPDFSRNSVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TY98</accession>
    <name>A0A3P7TY98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000291">
        <property type="protein sequence ID" value="VDO26976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZV1"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="175" mass="19515" checksum="C7B819A496125FAD" modified="2026-01-28" version="1">MDNDHGASSGTHLLDPSEYLKLKPKKSILKQPSAEEGKRIAEDRAHFDEMNIIATHHPADKDYGHMKIEEPKTPYHGYSDSEDDTDIHATKAPRRVSLVGAVDPVKLAESIEAGSSIQPSCLGKSLPDDDSEVELTPEQIAHKCEFEKKRKMHYNEGAALLRARELLAKDEESME</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UIT7</accession>
    <name>A0A3P7UIT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001094">
        <property type="protein sequence ID" value="VDO31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H3H2"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="178" mass="20408" checksum="2972B8EBF6BD3065" modified="2026-01-28" version="1">MLSSRTIILSRALGIRCFANSTDSSRIHHPVSTVTRKSVDDVLEQPQAPTKIKVSDEMSKEAADLAGVPKDFLRSRRVRIYRPAREATQSGWAGTKTWKIELDNQERWENLLIGWSSTGDPLSNISMAMDFASKEDAIRYCETNNLNYEVVEPNERIIKRKSYAENFSWNKRTRITNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UTR5</accession>
    <name>A0A3P7UTR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002894">
        <property type="protein sequence ID" value="VDO38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UTR5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="96" mass="10804" checksum="9F5913A44FC18632" modified="2019-02-13" version="1">MFAFRALRERVEADKNDKTVKDLVVLLFETALLSSGFTLEDPQLHASRIYRMIKLGLDITEDEEEEVVASVSGEKDECVPNLVGAEEDASRMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V6M3</accession>
    <name>A0A3P7V6M3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004659">
        <property type="protein sequence ID" value="VDO43111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V6M3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36234" checksum="FA9E13D938EE9489" modified="2019-02-13" version="1">MYLKVYTFSLLKNDTLLLVGSAELELRVFELHWLAKEEMDNEDDNSTKKLKIGENPVGYSEDMQGNNIIRCMKKGQILRRSKGRILQLAVSRDEKLIACVGSSHCVDIFRIYEDDESLKRLTKKLRKARKKSAESGDAEAISETDIKKDVTILISRIGEYKPSGKVKWVDFSSSIKQTGDEIRQYQLYILYAANTVLSESILVDFKSNEVQFDDLADLNQLGHRTDVRCLAVAENGFGFVSGSAESAIVWNLHSLKISHTLEDEQMTDITASLFVTGDKHDGNIFLFELATNEMLEMIKKAHDGAVWQLIPTPDKVKEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VUU7</accession>
    <name>A0A3P7VUU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008172">
        <property type="protein sequence ID" value="VDO52130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VUU7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="197" mass="22172" checksum="BBC9B29D31E3A114" modified="2019-02-13" version="1">MSPKRKQRSRSRNSYRSFCSASSPTKSDRTPESSRSYRRSESQNRSRSESSFADERSSDEETRSENERSTSGSGSICSTDRSSQVLSIRKRGVSGIVTPTDGSMSEEDDDEVEVDKEEEEQQKEQEHIEKNFDEIRAIGIEEKAVLFVKAEIGENNGCDETESLSSSTAASHLIEQNKIAEELRTRNKEVSALQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VXX3</accession>
    <name>A0A3P7VXX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003288">
        <property type="protein sequence ID" value="VDO39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HA60"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="253" mass="28474" checksum="A7D3E8776A837602" modified="2026-01-28" version="1">MILQLLSHAASVVIGALYPAFKTFKVIREGDFLQMKRWLKYWTVYAGFLAADTVGDILLLPYIIPGYLLMKLSFLLWTASPWTDGASTVHQKLIAPLLTIYERDIDEMLDNMGRSIQRQISKLGSGALDKARLGLLSLATTDDSSACQPFLTGRCVSVTVGQYSAVEEQAEEDIIRLVEEDTNIKRELEESGSNISADTLNRLRKNCAHSDDVNIIKKGRKRSHRNRKMEGDTKNQSHRTRRVTANRSTSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VYZ2</accession>
    <name>A0A3P7VYZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006738">
        <property type="protein sequence ID" value="VDO48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VYZ2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="223" mass="22360" checksum="92783C0ED6CD7EC5" modified="2019-02-13" version="1">MQNYSNLQLQAAAATGVVSASAAAYPGHSATRLTDSYSTVGSVPSTGGTYTSLSDYTNTLRTAAAAAVAASVAANPTSNNSYVGVTRIGTAVTSQPANTSSASGTSSSTSNYNSYDAAVYAAASSYLQSKAAGAANVWMGTTKKSNTTGHDGGSSSFSGMTSSNIAITGGTGSSGISGRSGYTGNRGRGTFSNKRFGQGRSADMQQFYCEVCKISCAGAQIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YNC7</accession>
    <name>A0A3P7YNC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002933">
        <property type="protein sequence ID" value="VDO38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H991"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="81" mass="8551" checksum="31D3C38052477CF4" modified="2026-01-28" version="1">MPVPQYQGVAGHPQVSCWQKMKMGLLMGVFIGCASGAIIGTASALSMGFRGRSLMAQVGRYSTKMGGSFAVFMMIAQGLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YYU2</accession>
    <name>A0A3P7YYU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004305">
        <property type="protein sequence ID" value="VDO42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="82" mass="8965" checksum="8F5864CD5F3ECA09" modified="2026-01-28" version="1">MIAGSGELCKFTANRFVHLDDNDLVCTVQSPSFTSEHSVRIRLCAYVCMNPFMCTMACDVSACVRDAVLCAKVGEHLASVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZHB7</accession>
    <name>A0A3P7ZHB7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS7096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007165">
        <property type="protein sequence ID" value="VDO49292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZHB7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO49292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="131" mass="13612" checksum="64AD244EF6647524" modified="2019-02-13" version="1">MNVFIGSIGKTPKATFESAFALALGIGLQNFPEGLAVSLPLAAFGHTKFRAFIYGQLSGMVEPMGALAGVTAVVLMEPILPYALSFAAGAMIYVVLDDIIPEAQRNGNGRLASLSSVIGFLVMMSLDVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B3N0</accession>
    <name>A0A3P8B3N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039879">
        <property type="protein sequence ID" value="VDP11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYN9"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="152" mass="17272" checksum="A0A2A31EEE5FE8B3" modified="2026-01-28" version="1">MRAVIQRVTKAGVSIDGQLESSIERGICVLLAIGVDDTSDDIQYMVRKLLGIRMFPNVESGKRWDKSVKDLGLEILCVSQFTLYSFLKGNKLDFHRSMTPTESQQFYQNFMSELRKAYAPERIKDGRFGAMMNVQIENDGPVTLILDSKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BM25</accession>
    <name>A0A3P8BM25_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS15583</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042406">
        <property type="protein sequence ID" value="VDP22701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="13">
        <location>
            <begin position="247"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP22701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="368" mass="41626" checksum="6310018D9BC90331" modified="2019-02-13" version="1" fragment="single">MNHNHPTFSAKVQSCNSDSDGTACSKSRKTLTSGKLVLEPSQLASNTERTTSAHEDPLLMTYYKTKIHLTTFLKTLQFSSNISFRRENRDCVPYNSRSSNIMVDSKTKANKHRTESHVNEHGEEPYVNEHRIPRARTWKRSPHGRPQIILRHETKMEGSLIVIVELDICFAFRVVVPVTSKRQXXXXANKHFYSRRDIMKVTSKRQSTSCLPVAPKCKKKCDDIDRGEMLKCSQNGRIFEVPGRVASIELLNFMCHKSLKINFDVFNRNCFFIGGSNGSGKSALFAALNIGLGGRGSQNERGNAVKQYIKDGQNRAKIRIVLTNRGFGRHPDYDDAIAVERTINLTSSAYQLKSITYEEGRCRGSFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BYA6</accession>
    <name>A0A3P8BYA6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018134">
        <property type="protein sequence ID" value="VDO81248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BYA6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO81248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="144" mass="16619" checksum="2BC8D17330D2A410" modified="2019-02-13" version="1" fragment="single">MISPRNILNFSKLFQGKISIHKWCKCVENISGLHLPWYSLAPQIVTVTDDGKNVLYKQNPSVVQIVSGNKKIMQKKPYVIETLYRHKNTLEALFRFMDKDNSGFVSLDEFIDACKILGQYTRNPLKIPHLEQIAECIDFNKDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXU2</accession>
    <name>A0A183GXU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytosolic non-specific dipeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS52</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000012">
        <property type="protein sequence ID" value="VDO24342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXU2"/>
    <dbReference type="STRING" id="387005.A0A183GXU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000005101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000005101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000005101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="208"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO24342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000005101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="52993" checksum="75CE20522B7F78E0" modified="2016-09-07" version="1">MDLYHKFAKEVDANQKKFVERLREAVAIPSVSGQSQRRADVIRMVQWTKTQLEKLGAKVELCDIGKQVLSDDSKIDLPPVLFATLGDDKSKKTLLIYGHLDVQPADNLDGWNTEPFSLVEKDGKLYGRGSTDDKGPVIAWINALETLRKCEIPIPVNIKFCFEAMEESGSVGLEKILEEKKDTFLNDVNFTCISDSYWLGKTKPCISYGLRGLCYYFIEITGCKQDLHSGVFGGSIYEPMSDLTWVMSQLTDVKGNIMIGGIMDLVASITDEEKKLYETLDFNVEEYRNDIGAIKLLDDSKEKILMNRWRNPTLSLHGIVGASSGEDANTIIPAKVIGKFSIRLVPNMEPAKVDSLVIHHLNALWKTRGSPNQFEVKPHNSGIYWLSDFKDPHYQCAARAIQKVYGVEPDYIREGGSIPITIRFQDLTKGSVLLLPIGASDDMAHSQNEKINLVNYIEGIKLMGTYILELCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H007</accession>
    <name>A0A183H007_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CXXC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS817</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000324">
        <property type="protein sequence ID" value="VDO27197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H007"/>
    <dbReference type="STRING" id="387005.A0A183H007"/>
    <dbReference type="WBParaSite" id="OFLC_0000081601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000081601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000081601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO27197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000081601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17244" checksum="6CC0547F29417A3C" modified="2016-09-07" version="1">MSVPLSMGPMLLMESRQTNGPIYHGAHYMQPGPPLSSAVPNGTHIPPHLMQPHHSVHGQAAPSGQHIITSSMNRSQRCGVCRGCQCKPCGQCTYCQDSPQFGGPGVKKQSCIERRCLRVLENRLQRDAPTFKARVGCNQCEDCRMPDCQICLVCLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H074</accession>
    <name>A0A183H074_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS884</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000360">
        <property type="protein sequence ID" value="VDO27448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H074"/>
    <dbReference type="WBParaSite" id="OFLC_0000088301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000088301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000088301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="5">
        <location>
            <begin position="654"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO27448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000088301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1599" mass="177298" checksum="576A0E2FD530F131" modified="2016-09-07" version="1">MLDGQLSTMYSSGSPEAGSDNAETRGEFLDKLTKARNAVPPGSLLHSIFSVPDINKMIEVGSWILASPKVNELTVTNRDGNPQRLIIVEDLPGFIFESNRQTKHCFQAERTLGLDFVTGWAARGGGRRLRFRAETQKAKLQEMAKEIWDNYLKEAHSKPRDALIELQKASSMVKEICQRKNGRLPEHMLSELEAALKCMRSSVVNDRLLSTFELSISGIVDALLAFLKFVQKDIDCEIAIIFRKVFADQRSLSALVCKMVSILDAVEKFPQYLYDTPGGSSFGLQLLNRRIKLKLEQFNPNTPSQMQLLDRSGRTMKIEPLSTVKQLKYYILRMVAKQWYDRGRETFHFVEEIRNAKKRGAKISFTYTNDFDDRGIIYWLGTNGKTVAEWTNPASVHVVFVTSSDGEHLPYGQHEDILSRDALNCHTSDDKNAYFTIDLGVYFYPNTYTLRHARGYGRSALRNWLLQASHNGRIWDILVVHENDTSLNYPGSTATWPIVCPESKGPYRYIRIAQNGKNASNQNHYLSLSGFEIYGDVVDVVVDDFKMLEEKPSMSSRRSKKCIASTKEISVKENSASEAPLASTNADIRMATSLNDASVVHLSGSQTNNKIVSGIVESDLMHSTTNTMKNRTFRYRRGSRLLAANITGRGVRIANVSDAMVCPVGSRVVRGPDWKWDDQGSNMEGTVISVIDNGWVDVQWDDCTSNSYRFGADGKYDIELKSIEWTSSLRRGFRIVGTRRENHAAVTLPSTGSGQVPPGFARQLPPVPRGFMDCSPTGTLRKVKPGGSSFSRYHQSISSRNSAETGGFDRNISDSCLHCGSQEHRTKDCTNGLDCSNSQKSEINAEEGGSTSDAKVITNNQLSSTIAQKSMSTTNLFDGSEAEKRASVASTNQAASAESLQHQTPSLENLLARSKIFDVPEVVSDDIPAVENSSTAVDTDQESVSTNNYAGLDTSFESFDGAVTVIEQTHDVNVSLKTSTYVGGSQPMLLDEDRETFGKTQVIKQRDTCSHSQDSVKSTVQNDPAIINNNITRSLEEANARNLASLSVSAPNLVVLRQLQQSGTMSSADQVLVSGDDDLVRNILQDLANDPLRSLRRFALAGSGSSLNNENDNAIRESIRRYLFNEEDERIMDESFGALTHEIIRRNADMSNEVSDRIDAITPIADDESNETRLEDGWKQRGDLSGMQGNTLTLEPVKISLVPMMLQSFSAGRRIITEENSGHREASTDEISTGGSAVFYSTDGRASSSSCSRRQFPEEDTSDKVEPSMEATGSNQSDGSQKTPSRLSFGTASRSVSGTQSVAYSRRSMQNTGGSFRSRLGSYADVLRTVVMQQIIDSGGSLNGLELEEIEDDIYDDEMQDEGNEDDCDEEYSSGLSVEALAQAAAALRRQSSGANTGSSGELKLNWKQIVMGEAGRLINDRGLRVSTSPSDNKQSRRGISRNWDDEFVLKHQLPALIPAFDPRPGRTNVNQIQDVELPHDINESQSEAAFPSDYSVLHSEEEEPELRLYIQGPNLANINNVTVELDDNDRSIFFYLQQLVQSVEWGQKNERTRRVWEPTYTLIYGDACDNNELPRTVNKKVAEMNDVPENVAHVSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0M0</accession>
    <name>A0A183H0M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1030</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000438">
        <property type="protein sequence ID" value="VDO27952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0M0"/>
    <dbReference type="WBParaSite" id="OFLC_0000102901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000102901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000102901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000102901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22633" checksum="369C1E962581B8A1" modified="2016-09-07" version="1">MYDIADVDDFPITFLISSIIIALPIVPVLILCQFKKMEKKKQTVLSVSHFPAIENNDSEFTDRKATNQTNAPVVAKLKSIETMHKIETPLWTKTNQSIEYMADNKGKHGLILEGEEIDHQMRKSSQKSNSSDYSLFDSQTSRRDIREQRLRLLKLNTTVARRVAAALEESEISRSAQDKKKKPTNQAVSFKLLYISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Y8</accession>
    <name>A0A183H0Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1148</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000501">
        <property type="protein sequence ID" value="VDO28426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Y8"/>
    <dbReference type="STRING" id="387005.A0A183H0Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0000114701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000114701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000114701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000114701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43238" checksum="A866A6F56F19A634" modified="2016-09-07" version="1">MAVKGCLNGDDQVASSSTSGSTESVKTTGQRDELIEFVNPIPVRYNYDDDVTIRFELFCTEKPMSSTGSDYRRNSDIIVRFRSSSEVLFWDSVDSMECELNAVVHRGRLSEEEDGNIREGSPGRFIVISERLPINRAFSEKQIRMEVSISQLEKRGKMKYTDLEVYLAIHRKNLKEDYIIVYRSPKTVQITSTSLHKFPEIVIPCEKLFGSVESRVIYFTLRNAANGDIIGEAGVFYSNLVADGKVNLKLRSRDINSNTLFGVSKRSFHSVGVLHINFYMDNNVMNFSSRNNTECRHRSAIELSSSLSFTKDRCQHLIKNTDDEKSGFSRSTNNVMLASGRTQAYLVSLLAPTIEVRLRQQSIQLAKPLIDNNFHKCSSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1E0</accession>
    <name>A0A183H1E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000589">
        <property type="protein sequence ID" value="VDO29025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1E0"/>
    <dbReference type="WBParaSite" id="OFLC_0000129901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000129901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000129901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000129901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="7212" checksum="EDC72FD2071C8AC9" modified="2016-09-07" version="1">MRYFTAYTLNVPLNALLLRRWVHLVLWLLHQRMKEMKKWIHYEIYHLHVFPCLHQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1G6</accession>
    <name>A0A183H1G6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000604">
        <property type="protein sequence ID" value="VDO29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1G6"/>
    <dbReference type="STRING" id="387005.A0A183H1G6"/>
    <dbReference type="WBParaSite" id="OFLC_0000132501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000132501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000132501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000132501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9811" checksum="7E00CE4D8876D320" modified="2016-09-07" version="1">MGKAWLGSSNSGGRDDCETEAISLDSCASVLEPSHREGKLDHMELVFIFTIFPVYCTVDGYIHSLCNPPLRVVSVYHNFFDCNPLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H252</accession>
    <name>A0A183H252_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Digestive organ expansion factor homolog (Trinotate prediction)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1562</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000762">
        <property type="protein sequence ID" value="VDO29993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H252"/>
    <dbReference type="STRING" id="387005.A0A183H252"/>
    <dbReference type="WBParaSite" id="OFLC_0000156101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000156101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000156101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 C-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000156101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="21429" checksum="4F14C86A876BD049" modified="2016-09-07" version="1">FQIEIPYCQELQRIDVDVAENQSDIRFKFFKEKILPKCELGTVIFIPSYFDFVRIRNYLKNENESFVQLHEYAKEGKVAKARELFYKKEKKFMLITERFHFYRRYNIKGIKSLTFYQSPVQPKFYHEMINQVDCNYAHVRLLYTKFDFLRMTHIFGDNCIRQIMSSTKTMHVLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2C6</accession>
    <name>A0A183H2C6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exportin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Importin-alpha re-exporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1636</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000813">
        <property type="protein sequence ID" value="VDO30255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2C6"/>
    <dbReference type="STRING" id="387005.A0A183H2C6"/>
    <dbReference type="WBParaSite" id="OFLC_0000163501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000163501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000163501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO30255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000163501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="949" mass="107531" checksum="5CEDDD37B3F9EECD" modified="2016-09-07" version="1">MASGAEAVMVAECLQRTLEPNAQIRRNAENQLKQMEQLPGFGMVCFDLIFDQQMLPAVALASAVSLKNFVKENWNKEKCMVEINDAERAQLRSKALQSMLGSSGNIQKQLSQVVCVMGKHDFPEEWPDLITILAQNLAEINPEKLTSTLYTLDELCKKYRYEVKSTKLWQELVIVLQAIAAPLTDLFAKMVECIPNKDLMSEAECQSWIEVTTLITKCFHSLCSQDLPEYFEDHLSTWINGFMALLKLQIAQMDAKSIDSEANILDKLKCCICEIITLYSQRYEEEIMPFMMPSDNNLMKAEKAEQRCWLIECVWQLLVSIDQKARYDTLVNASLGFLSSICQRSQYSVIFEHEEMLKTLYEDVIIKNVMLRKCDFELFEDDPFEYMRKDVEGSDIGTRRRGASDFLRALCRRPEESRILGILSGVLQSFLQESVTDLINNWLKKDVVYCLITAVAVKAETVKHGATITSDVVDVVDFYQTHVHSDLFMFDVDTLPILKTDALKYIVVFRNHLRPDHLIEVISAFLKLLSSRHTILHQYTAYALERLLLVKSKETGKVLLTHENVPVGQLIFALFACFETDSKAQNSHYLMKALMRCFNIIDIETAKSSAHIVDKLATMIGVAVKNPVNPLHLHYVFESLCVLIRQVYAVVDGGIDKFVVPLIESIFSSDAIDFVPYALQITALLLDQAEAQKQKTGTSCVDSYLPFFANLMKGELWLRTANIPAALLVIESFMRSHGKHILANYANNLLAVFQKLISSKALDQYGFQLANIFLHYVNQADVLTDSSLLIPMLRRIQFTKTTKFMKNFVLFLARFAVVRGSVILYQVLELIQTGMFTMVIDKILIPELSKMYNTTTYDEKRLCCIGFANLAADTVDKLGPQYGILVESLVQLVEASGCGPTPLNADDVEEQGTGFSTLELEQNDPYCKLSYAQHPDIIAAEIVNFKAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2M0</accession>
    <name>A0A183H2M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000869">
        <property type="protein sequence ID" value="VDO30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2M0"/>
    <dbReference type="STRING" id="387005.A0A183H2M0"/>
    <dbReference type="WBParaSite" id="OFLC_0000172901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000172901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000172901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002601">
        <property type="entry name" value="C6_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01681">
        <property type="entry name" value="C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C6" evidence="2">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000172901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27920" checksum="8E8BC1EFC17901BE" modified="2016-09-07" version="1">MRAKRQIEICSGCNNVLPISGMHLRNGERNGYLAVVYGANPFGCRTADLICDAGFLVNQTAIIYANGVKSTPLAMSLTGTAQIILTCDENVRWKAPNSRMNIWNVTCIFRDQPIPTTPVPPTVPPQPCSTCTNLIAARVKNPALNEGEGKLAIEYTLNEFGCRVAKITCSTSDEKVETIIYFNGMKNMPVVSSKVGAATISLSCHDNRRFRADNSRDNVENVTCLTRGSFPFIINYILIMLFNIYIYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Q5</accession>
    <name>A0A183H2Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1765</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000893">
        <property type="protein sequence ID" value="VDO30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Q5"/>
    <dbReference type="STRING" id="387005.A0A183H2Q5"/>
    <dbReference type="WBParaSite" id="OFLC_0000176401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000176401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000176401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000169">
        <property type="entry name" value="Serine/threonine-protein kinase 32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000176401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43264" checksum="B5276E8932CBDD25" modified="2016-09-07" version="1">MGGRCSRRAPSPTHPKLSDFLIIRSIGGGTFGKVCIAQYRRTKKYFTFKYINKRRCVQHMITDNVLYELNLLAHLSHPFIINLWFTFQDERHIYMVSDLLLGGNLRYHLNQQGRFAEDRSKLYVYEIALALDYLHKEMIIHRDVKPENILLDDEGHAHLTDFNLATRLAPNTYATSISGTRPYMAPEILLCSLGYLAGYDHRVDWYSLGICFYEMLMGRRPFEYAVHSSSQQILCLMSKSLMALPSQWPSDLISFISCMLRYEVGSRIASFKAFSQHRYMERINMNDVFARKTAPVFIPRSSIANCDPTYEVGIGILDSSSTNRQRCRMVISKEEIEQKVNEFTQAFVSYNREHQYRMNQKVTNVMAFLIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H403</accession>
    <name>A0A183H403_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IF rod domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2213</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001226">
        <property type="protein sequence ID" value="VDO32254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H403"/>
    <dbReference type="STRING" id="387005.A0A183H403"/>
    <dbReference type="WBParaSite" id="OFLC_0000221201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000221201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000221201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF6">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="4">
        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO32254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000221201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15009" checksum="C1DB6D9DB20C483A" modified="2016-09-07" version="1">MYASESLRSLPGASGGKLISNEIDEYKIKLIIFFGFISDSCLKSLGRVLKMVTEMGSASIGGISPALSANAAKSFLEATDKEKKEMQGLNDRLGNYIDRVKKLEEQNRKLVADLEELRGRWGKDTSEIKVKLMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5I8</accession>
    <name>A0A183H5I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GXGXG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2748</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001653">
        <property type="protein sequence ID" value="VDO34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5I8"/>
    <dbReference type="STRING" id="387005.A0A183H5I8"/>
    <dbReference type="WBParaSite" id="OFLC_0000274701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000274701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000274701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate synthase alpha subunit C-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000274701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12757" checksum="21B406F233DDA725" modified="2016-09-07" version="1">MDHKAESDSRLALFRDVADERYAVRYSGTDVIIESIGDYGCHYMTGGKVITLHITEPNFAPAMSGGLGQSSHFISMTTLDLEEPNSEDLEQMKQMIDMFVREIRPEIGSVILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7C6</accession>
    <name>A0A183H7C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3391</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002250">
        <property type="protein sequence ID" value="VDO36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7C6"/>
    <dbReference type="STRING" id="387005.A0A183H7C6"/>
    <dbReference type="WBParaSite" id="OFLC_0000338701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000338701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000338701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000338701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36827" checksum="50CF25D2C1E8F45E" modified="2016-09-07" version="1">MKTFPLHKIDWEDVMAEREYEKYLQFSRTKLMNHLTSFALHRLLVRQGCQFRVTSNVVDVGNMEPRGRRSRSTSLSSSDTALVLTSGVGTLLTLIESPAFENVSGKYFDCHGKQTRSSSDATDERLQQKLWEMSEQLCKDYLNSSSHISTNCTTNDVNYLAHYVLSRSLFTLLKNNVPSRLVLVSSICYEWYPLDWSDLQSSKNYEKYTQYSRTKLMIHLMTFKLARLFSGSGVICNVLEPGVIETKLLRAGGYSGAPVCEGSRVCVFLCTSDSVTTNGAYYDNNCKRITKLFKDSVDEKQQENLWQLTDKLCEEKGIILPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8R5</accession>
    <name>A0A183H8R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3877</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002745">
        <property type="protein sequence ID" value="VDO38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8R5"/>
    <dbReference type="STRING" id="387005.A0A183H8R5"/>
    <dbReference type="WBParaSite" id="OFLC_0000387601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000387601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000387601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAN2-PAN3 deadenylation complex catalytic subunit PAN2 N-terminal" evidence="1">
        <location>
            <begin position="52"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000387601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45831" checksum="93F34643774A2459" modified="2016-09-07" version="1">MYGSSPGHSEDVLISADGLTPMNNEVRIPEGGFALLSTAPQNATLAHFITALAFDPYQELLWTGNNMGRVVSFYGAQLDKYTAFLSEANSNIRALLASEAVIFSLTSKRLKANRRQGISLFTHTSDHMTDLTCMHRLPDVPHKLLLGGNQQQIIQFDVETQKEIRIVSVKQKNCLALRSNQKFLFSSDSEGNVTLRHLTTVDAIHALQAHQGSVADFDVCGNKLITCGYSPRILMRGFHCRLGKMAGDRFIMIYDLRTLRSLPPVPLPMAPSYCRFLPSYSDGRIMVCSQTGELIIMDLNEQSSQIPIQLDTNGFVITSLDVSTSKQCIAFGDQTGLIHLFSDRMEPIFNENSWGTDFPDPIAFHPPVNIDDPEPSYGVFPLPFPMDDHYASDWPEQLCIKRFRYVFNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9F6</accession>
    <name>A0A183H9F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003010">
        <property type="protein sequence ID" value="VDO38952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9F6"/>
    <dbReference type="STRING" id="387005.A0A183H9F6"/>
    <dbReference type="WBParaSite" id="OFLC_0000411701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000411701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000411701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000411701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14384" checksum="3F628690CE65A56B" modified="2016-09-07" version="1">MPVRHREKLPSTIETSICTASRDINRPISVFIDHCVQQWGSTSSDPSEEEKTKIMSEKLCEKRKRITREPWHRYIVPGYDGEDGFPEYRFRWELFGEAVFYTSVDMSLQPVTFCCFSRAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9G2</accession>
    <name>A0A183H9G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4124</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003015">
        <property type="protein sequence ID" value="VDO38982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9G2"/>
    <dbReference type="STRING" id="387005.A0A183H9G2"/>
    <dbReference type="WBParaSite" id="OFLC_0000412301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000412301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000412301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000412301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6312" checksum="7E14857E029172B2" modified="2016-09-07" version="1">MADCIDKLRSAMLECQEVLDGVKNREVKLDPRVEVKHDMQRRLAAYENNAQMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9H8</accession>
    <name>A0A183H9H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4141</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003033">
        <property type="protein sequence ID" value="VDO39064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9H8"/>
    <dbReference type="STRING" id="387005.A0A183H9H8"/>
    <dbReference type="WBParaSite" id="OFLC_0000413901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000413901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000413901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF4">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000413901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="62870" checksum="B748D51374E4CB9E" modified="2016-09-07" version="1">QFRSLKVRLVRTSASEVCVTDFHGHLWKYGGGRLEFDSLGRVQVRPLQLAPRRKVLQLCAGRKHFVCLAVPLIDGKNDTDVENSPTLGIRQSNKCEKCREEYELRLSTLMYMADQKNESRVSFASCEKGLVVKANFDAHNPCLFLDANKSPREHQTFVQCSSSRSTKTAVVRPWKQASFDEFEMTEMKNAWDGLGKNSTFVSIENLPDMYYKQNTKFVDMEDFSSSHTIYNGNYSKSDERISLADSQDDSDLLPEIWTWGANESGQLGHGDLAVRREPFKVIDLSSMYCIKVAAGDDHTIALTGAGKLYVWGSNSDGQLKQADESYVTKPTLFKVGSHSFVLDAFASGCQTGIIVGGVANSPTAYLCGRNTAKKSPQSISLPKEIGWPGWILIENKNIAIGVYESTNEIDEYFLEVFIFFRYAEFMQRICQLCQKMHERSHTVNNPPLSTLLNKLILSSAGYSTHMFNKNESNRKRLMKMVRDNLCDTGSVSFGKTLKTYITKYFLNSFFQFHADFVECLAYGCFTELDIGYDFSILYDIMAKCIDRNLLFFLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Y5</accession>
    <name>A0A183H9Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4296</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003202">
        <property type="protein sequence ID" value="VDO39553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Y5"/>
    <dbReference type="STRING" id="387005.A0A183H9Y5"/>
    <dbReference type="WBParaSite" id="OFLC_0000429601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000429601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000429601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF45">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN SHOC-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO39553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000429601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30443" checksum="42EE008DF8491415" modified="2016-09-07" version="1">MGNDSSKTESSSAEAHGSSGKKKINFGNKHRLSSSVVHHHLETAQKSRVLQLRNYGMKILPEQLQEVCEILRNLDVSQNKIRTLPTFIGLFNNLKQLHLSNNELESLPDEIGVLKKLEILDLSCNRLNCLPQSLAGLCSLKTLNLSKNRFTHLPICVCHLSALNILDISSNFIEFLPDEVKFLKTSELNLNQNRLNSLNAANLVHCEALRTLRVEENCLNKTDFISDFLINSNVSLIAYAGNLFQEKDFQNLPGYDEYQNRYTATKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA97</accession>
    <name>A0A183HA97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4410</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003331">
        <property type="protein sequence ID" value="VDO39918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA97"/>
    <dbReference type="STRING" id="387005.A0A183HA97"/>
    <dbReference type="WBParaSite" id="OFLC_0000440801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000440801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000440801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO39918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000440801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16686" checksum="F1957EE1075C0609" modified="2016-09-07" version="1">MNTVRIIVFSDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIDLDGKTIKLQIIDLQWDTAGQERFRTITSSYYRGAHGIIVVYDITDQESFNNVKQWLQEIDRYACENVNKLLVGNKCDLTTRRAVEQSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAX5</accession>
    <name>A0A183HAX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4638</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003623">
        <property type="protein sequence ID" value="VDO40588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAX5"/>
    <dbReference type="STRING" id="387005.A0A183HAX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000463601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000463601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000463601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000463601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26322" checksum="8308B99A2F0E82B5" modified="2016-09-07" version="1">MVSDQEKFRSDSNYSCTEDDKNYINDTNYDNMKLTGISMSSSSSLSSSSTSTTLKSAESDLNEKALEKLSTYYRSTTTTPTRSLVAQESITNSTTSGRDWGHVSAETLIRPSRTYRIIDSDVSQKILQRLVADKVAAVQTSTGKGTRFLKRKGSSKETSTSLFQRQPNFGSQVWNKSEELSLISTTPNFRNHFEVVRTSSFNENQTQIIRKHLDYNRNSLPLNIISLNNELVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB77</accession>
    <name>A0A183HB77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphorylase b kinase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003749">
        <property type="protein sequence ID" value="VDO40905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB77"/>
    <dbReference type="STRING" id="387005.A0A183HB77"/>
    <dbReference type="WBParaSite" id="OFLC_0000473801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000473801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000473801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000473801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15811" checksum="444C4AB8929F268B" modified="2016-09-07" version="1">MKKKKQLKEQVYRAKLRIRLGDERKEFFKNSLPILDYILVMIDGLTLEADPPYQQIQYMFEKLMIEMGVKWDDFYDWEETEKIQSKQLVSMNGVISTTSTAMDIYSKCRSTQLRVAMTTTASTESSSSLPYVQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBB3</accession>
    <name>A0A183HBB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA-synt_2d domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4774</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003799">
        <property type="protein sequence ID" value="VDO41000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBB3"/>
    <dbReference type="STRING" id="387005.A0A183HBB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000477401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000477401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000477401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenylalanyl-tRNA synthetase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000477401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9323" checksum="34D38E245ED4FFFA" modified="2016-09-07" version="1">MEIFAFHKGLGKWVEIGNSGMFRPEMLLPMGLPADVNVAGYGLSLERPTMIRYGIDNIRDLFGPKVDLRMIYENPICYLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBQ2</accession>
    <name>A0A183HBQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4913</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003976">
        <property type="protein sequence ID" value="VDO41422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBQ2"/>
    <dbReference type="STRING" id="387005.A0A183HBQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000491301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000491301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000491301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190:SF1">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000491301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="57732" checksum="E763CAE12FC6CF79" modified="2016-09-07" version="1">MMMPSSLGGDSENAKHHQQLVQSASMLPSPYSFLPSVFGNAQLDMPLFRPPESNLGAIYLSQLATAAALNQGQNGSNGSTINEQQEEAIGENNRTEVTASTSSEIATSSCGAESPLSSKPFNTVEREMKCANERNSADNAALSPTKVSAEDTIVTENENLQPSSASELQQLDLSKWISDFFPGLPNNVSALNMAALTQRMPPMLEQMQLMNQYFSPGSVEDSLRVLAALGNTNGSAGTVPSANCSPGSILNSSFASSAGHSKDTYCEICDKNFCNRYFLRTHKWKKHGIPFPGKYSPFECDVTSLASPTVSQNLSLDLPTTSTGMNLSPAELIAALCNQNVLEASQISPSKTALSQPTSVIVNCLSSADPSPIKRARMTDEGNKNDELIGAVRSDSIKIDEEVFASVASQLPNTGDLFAMIARQAQENAIAQELLSSLKTEGIQTQQQSSPLKHSSASKEACEMCGQECESRATLQHHLLLQHNILNSFLNSFNLLSPLGQLQSQQQSQKQQNNQGNDADRTRNSMAVPGMVTSPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBV6</accession>
    <name>A0A183HBV6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4967</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004055">
        <property type="protein sequence ID" value="VDO41619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBV6"/>
    <dbReference type="STRING" id="387005.A0A183HBV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000496701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000496701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000496701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO41619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000496701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27816" checksum="B497D1FB6E29F5D7" modified="2016-09-07" version="1">MYARFGGKQWIRQMVFGAFLLPCLVSSVAFLVNIVAISYHASRAIPFTIMLAVTAICLFVILPLTLVGTVLGRNVKGQSDNPCRVNAVPRPIPDKKWFLEPSLIVLLGGILPFGSIFIEMYFIFTSFWAYKIYYVFGFMLLVTLILAIVTMCVTVVCTYFLLNAEDYRWRWTSFLAGASTSFYVYLYSIYYFLFKTKMYGLFQTVFYFGYMGLFSAALGFMCGTIGYWGAAKFIHKIYSTVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBX4</accession>
    <name>A0A183HBX4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4986</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004072">
        <property type="protein sequence ID" value="VDO41679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBX4"/>
    <dbReference type="STRING" id="387005.A0A183HBX4"/>
    <dbReference type="WBParaSite" id="OFLC_0000498501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000498501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000498501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO41679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000498501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29842" checksum="991A783EB2162CAF" modified="2016-09-07" version="1">MIGILNDMVFNLHLIPLDRLLTSLVLHPTDDGATEIAMLIIHSLQFPELSYKEMEAKMRREMQIELGMRPIEQPIVSPELHMPIYYGNIMERILPVVDIILFRAIETVVADQLFTTLLMCFKPCYRYHPQPAAYMYSVLYCLDKTISHTVRARDFVLEICGQLEDRDGKYALLTPSFISDNHQLSLPSQFCQALVDRILQASNYAHQPPAFANKDWRFAEMPPAGQALTGACIELLASPHAPLITAHALIDLVFIRPLHQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCD8</accession>
    <name>A0A183HCD8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">OFLC_LOCUS5150</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01004281">
        <property type="protein sequence ID" value="VDO42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCD8"/>
    <dbReference type="STRING" id="387005.A0A183HCD8"/>
    <dbReference type="WBParaSite" id="OFLC_0000514901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000514901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000514901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="20">
        <location>
            <begin position="13"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="316"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDO42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000514901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43985" checksum="B5B3BB5DA3942DCD" modified="2016-09-07" version="1">MEGFSSVKTLCKDRSDRATAEQVLDKRTLLVLRRLLQRDIFDEIEGCISTGKEANVYHALTVDGKSLAVKVYKTSILIFRDRDRYVSGEFRYRHGYCKRNPRKLITVWAEKEMRNLSRMYSAGLPVPKPIIVKQNVLVMDFIGINSWPAALLKDAELSFELADALYVELVGHMRKMYRDCRLVHADLSEYNIMVMEGKLYIIDVSQSVEHDHPRSLEFLRSDCSNVTKFFRSRGVPVLSTRDLFLLVADPSIKTENDLQKLMSKRNFETLANDTLFMNAFIAQKLEQVLYFERDQQIAKDGGEIPNPFQTMISQVKTDKDESINEENEFKNTELEDQRDLDQYSDSTRSFSSEEKEQKNHKTTIYVRNRDESPNTKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCP2</accession>
    <name>A0A183HCP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5254</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004422">
        <property type="protein sequence ID" value="VDO42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCP2"/>
    <dbReference type="STRING" id="387005.A0A183HCP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000525301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000525301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000525301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000525301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39906" checksum="DF1AF3A35E761B7A" modified="2016-09-07" version="1">MNRRTNIMSQKKPFIRPTPQIPLLKKSLTAVTIGSSTQNKLNSRGMTTGNDNLVLSKVLPSLPSSSESSVHLQRQNSDNTPVHNKNACENLASEYAHLSESIDTSMKTDLIVKTGSSSQDQNVKDDDDVSIAGTVFNEPWDSNVWENLLDLAHYGDEKPSTLTRNHDTNQIVLDEAIAEEGDDEVICSLEMSYDGDEGRSFQKLLSSVDDSRNNDDYGVVIRRSDNHLNNNVESDGRRNGIININTHLKSEDSLDRQQQLETICKSVTSGSGDPEASNSIMNVSNAGEMSDGTATIDSHKSTNTHSLPHILPRYSKLDDSWLESLDDIPTSIRALSPIISPPRLKNSLSADPGTKIQEYVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCU5</accession>
    <name>A0A183HCU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004488">
        <property type="protein sequence ID" value="VDO42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCU5"/>
    <dbReference type="STRING" id="387005.A0A183HCU5"/>
    <dbReference type="WBParaSite" id="OFLC_0000530601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000530601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000530601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000530601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19241" checksum="3B4C6D538207E34A" modified="2016-09-07" version="1">MESETSIDILESADLVNEKRRRMLARLEARHTKDTAGTKISSTDTTDFDELLAKATCLINSSEMNIEPEFLQELEIALTLIPPGRQSRRLKDALNVLRCQMQERIGLAHQQTAFSFSSKEENAAKLTEQKAKIAEYSPLGPIQTTVKSLKQKAITITAEHGKELVLKGGDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD56</accession>
    <name>A0A183HD56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004643">
        <property type="protein sequence ID" value="VDO43072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD56"/>
    <dbReference type="WBParaSite" id="OFLC_0000541701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000541701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000541701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000541701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18219" checksum="89D7BCA761825742" modified="2016-09-07" version="1">MRKIGKVEGKLGQVAAMSVQSFIISDCRNSMCEYRYNSLGQIAKATTTCVFTSPFDAVSGVFEMPSLQPELEVSPSLQTIKPLLSSLIEKKRKDIEIIQWTEYCMVVIYAFTIALVFIIKLLIEVCILILHPDDIPIFEQYFTTVYKCLFFGLAAENLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE56</accession>
    <name>A0A183HE56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5768</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005135">
        <property type="protein sequence ID" value="VDO44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE56"/>
    <dbReference type="STRING" id="387005.A0A183HE56"/>
    <dbReference type="WBParaSite" id="OFLC_0000576701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000576701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000576701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000576701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16721" checksum="5B16526442459EAA" modified="2016-09-07" version="1">MLIDWWYSELAEMLFHNISILITSLIICTIISCKYQRKPKSLKFIDENDPQADTLYNIKTEIAFPKRISDEKQSSFKKDANIAMSWSREYESNMPQSLSLSSPKTVLNSTKYFKLASCDDTQTPSSPDRLNRMQTSPNSAIILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE88</accession>
    <name>A0A183HE88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase_S8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS5800</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005180">
        <property type="protein sequence ID" value="VDO44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE88"/>
    <dbReference type="STRING" id="387005.A0A183HE88"/>
    <dbReference type="WBParaSite" id="OFLC_0000579901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000579901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000579901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000021">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="13"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000579901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27115" checksum="E1CD77FD331D39B2" modified="2016-09-07" version="1">MNVIKAWELGYTGKGVVVTVLDDGIQHNHTDIASNYDPQASYDLNDNDPDPMPILNKINGHGTRCAGEIAMAPNNSFCGVGIAYNAKIGGVRMLDGKVTDRIEAEALSYNIDHIDIYSASWGPKDDGKTVDGPGRLTQKAILKGIQQGRGGKGVIYVWASGNGGMQDDDCNCDGYMDTIYTLSVSSVTADGTSPWYAEKCAATLASTFSNGQYEKQMITTTDIGNKCTGTFAGTSASSPMAAAIIALGLDAKFVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEK4</accession>
    <name>A0A183HEK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mon2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5917</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005349">
        <property type="protein sequence ID" value="VDO44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000591501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000591501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000591501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000591501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15399" checksum="DA1BFFD72A211323" modified="2016-09-07" version="1">VGSNADTDEDETVEEFIKLGLYKPEETDGNEEHYPKLMRLIAGLFYCVSSLFRALLLIDVGPRYMISRLNIALSDLDIIKTAVDIVDLIIRTLDDAAKADSASAMARILQTARNIVELYAWTSPRKHDSEISSVPVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEX1</accession>
    <name>A0A183HEX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UNC80_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6032</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005506">
        <property type="protein sequence ID" value="VDO45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEX1"/>
    <dbReference type="STRING" id="387005.A0A183HEX1"/>
    <dbReference type="WBParaSite" id="OFLC_0000603201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000603201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000603201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000603201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25607" checksum="73646CD85B4CC48E" modified="2016-09-07" version="1">MTLLWPRIFKIIRDLLGKKIGGIALYSFIDFMIDVNLPISLIILPFLQSKMAQKVLTEQEVAWQAEFKERLQLLGCASGMKIRGYGSLLAELSQELQMMKEEFSIKAFETARSHTPTITELHSDSGSSQSTVGHRHSNARLSNNEGRRLSTATIMKLNRIASSVHHKEAIPERTIVEGREDDNLNTMSSSMTTTNSHPSGSERRTIVELHDLPLFSKCRKSPNVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF62</accession>
    <name>A0A183HF62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spindle pole body component 110-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6124</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005651">
        <property type="protein sequence ID" value="VDO45513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF62"/>
    <dbReference type="STRING" id="387005.A0A183HF62"/>
    <dbReference type="WBParaSite" id="OFLC_0000612301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000612301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000612301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000612301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18163" checksum="7B7D31C82AF08C1D" modified="2016-09-07" version="1">MGYEEAWGLTSKNIAVDDMERNFVYEINDQDSQDAMQDSLTEEAKSLLSTHKPTQIDFFQKESTPLDYQNSASTPNTIKRTRSVSSDATPVATAFSEGTLSLPHRRAYLNIAETKEENKKLKAEVFDLKSQVFMLKRNLPSIVDSEGKDFAEEMTSDIHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFD0</accession>
    <name>A0A183HFD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PRKG1_interact domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6192</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005752">
        <property type="protein sequence ID" value="VDO45731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFD0"/>
    <dbReference type="STRING" id="387005.A0A183HFD0"/>
    <dbReference type="WBParaSite" id="OFLC_0000619101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000619101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000619101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21930">
        <property type="entry name" value="IPD_PPP1R12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO45731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000619101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27315" checksum="58974328DD2F88AF" modified="2016-09-07" version="1">MEPNMPNESEAERRSRAKRQRDSRRSTQGVTREQLRVATTLTVRRDDREKERENEIQRNGKSSSSSLESTSLHEIEKKVGEERKDLDTKTYSPSQSLSAVRRRSQAPRTTRRVTGPVRIDDLQSEETSDDSLQKSGGDLSSIGTIIRSSPNDLSNPVTATTSYNFRDNALTTVAYNQAALTNKIRTAQTNSIHIGGSTASFQMLNSRANCQESAVDYKTLYEKEKQETERLRRRIEELSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFR0</accession>
    <name>A0A183HFR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6321</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005941">
        <property type="protein sequence ID" value="VDO46145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFR0"/>
    <dbReference type="STRING" id="387005.A0A183HFR0"/>
    <dbReference type="WBParaSite" id="OFLC_0000632101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000632101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000632101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000632101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18498" checksum="C36FBFBD33A7C45E" modified="2016-09-07" version="1">MLQCCRLIAHLNYKHAELSKKEREEMITKGDKLLEKLRDISSNRLLAYRSRILPMLSPTVDITRQITPIHFPSLAQAETISISVTAAATTTSNDQSLIPISATTDIISTNHILKKMIESVKFDGNDETSLKRIKSNVLDFDNFDTEPSIIHTTGIIVYQVPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFW9</accession>
    <name>A0A183HFW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6381</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006028">
        <property type="protein sequence ID" value="VDO46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFW9"/>
    <dbReference type="STRING" id="387005.A0A183HFW9"/>
    <dbReference type="WBParaSite" id="OFLC_0000638001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000638001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000638001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000638001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26641" checksum="F8DC4515AE9A5462" modified="2016-09-07" version="1">MDHKKNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIKSTAISLFFELEAKDLSFIKGESQVEVNTVNGEQKKLPGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEELYQTFQRIVENINVIIATYGDDDGPMGPIMVDPAVGNVGFGSGLHGWAFTLKQFAEIYAEKFGVQVCELCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG03</accession>
    <name>A0A183HG03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006078">
        <property type="protein sequence ID" value="VDO46478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG03"/>
    <dbReference type="STRING" id="387005.A0A183HG03"/>
    <dbReference type="WBParaSite" id="OFLC_0000641401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000641401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000641401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000641401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="16036" checksum="E6D9FCEB299818FF" modified="2016-09-07" version="1">MSVEEQVLERRRLNRSKERRRRRKNLAKNLPIKEPLNFVLQVYIDFGFAQRMSDKEIGRLVRQMGRVWGLQKKNPGLQVTLLSPDERFLCEGRQKLTGFDHFNWIISNKNINEVRSMLCFNFIQCCLYSLIVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGF1</accession>
    <name>A0A183HGF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6559</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006305">
        <property type="protein sequence ID" value="VDO46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGF1"/>
    <dbReference type="STRING" id="387005.A0A183HGF1"/>
    <dbReference type="WBParaSite" id="OFLC_0000656201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000656201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000656201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000656201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13822" checksum="25DF7B5BDC6DCDAE" modified="2016-09-07" version="1">TIKHCYSGRISSSSVCNSAKPPEEYVTFKSSLDLELAESPNPSSKSRVIMPVTKSQDLSNTSQISSKNEVSSHSGKKHSSSISASRHSEAFYMEAKGMIIIALIIVILILCIQIFLETKSEAEWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGJ2</accession>
    <name>A0A183HGJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DCB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6603</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006378">
        <property type="protein sequence ID" value="VDO47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGJ2"/>
    <dbReference type="STRING" id="387005.A0A183HGJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000660301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000660301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000660301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000660301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27222" checksum="A7320680D316AC38" modified="2016-09-07" version="1">MERYKTCKSVSRYLHDENAFDMDNELRKAAAMFLRNAIGRILADRDIKKKEHAQLRKACEQAIEELSADRMNEDQGVTTNVLPSKAQYIYADRYFLPFDLACHSKSPRIVIIALDCLQKLIAYGHLVGNGIDVANPDRLLIDRIVEAICSPFYGPNTDDGVQLQILKAILAVVLAPTCEVHRATLLLAVRTCFNIYLASRSPINQSTAKASLTQVINTVFGSALNAENGASSPHQNDEKVIFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGZ6</accession>
    <name>A0A183HGZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006615">
        <property type="protein sequence ID" value="VDO47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000675701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000675701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000675701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000675701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8589" checksum="D3CA145FA0251D96" modified="2016-09-07" version="1">MYQTLVRCLRSSSLLLTYDTALKDQLLNGVIEEVPSEDERGVVPYLPHHEVSIPSKNQHINEDLKASMKFYIEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH50</accession>
    <name>A0A183HH50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006698">
        <property type="protein sequence ID" value="VDO47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH50"/>
    <dbReference type="STRING" id="387005.A0A183HH50"/>
    <dbReference type="WBParaSite" id="OFLC_0000681101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000681101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000681101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000681101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19281" checksum="D0FB4FD2620F8C0D" modified="2016-09-07" version="1">MGTEEKLQIVLELLKYLKIFPQTEECLTSSPLLLEEHQEDSGIENNCRSSSIDDHSPAASVDFFPSIELNQLDTRNSFTSSLSPSPPNHQHYCYQHLELSSSSILSFPEKSFTHPTLSHSSTATEDNYLTPSTSKLFRTGTITKADFPEQVSEFRLLIIIVIFIVIIINDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHL2</accession>
    <name>A0A183HHL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6978</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006984">
        <property type="protein sequence ID" value="VDO48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHL2"/>
    <dbReference type="STRING" id="387005.A0A183HHL2"/>
    <dbReference type="WBParaSite" id="OFLC_0000697301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000697301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000697301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000697301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14281" checksum="BDD29F73C4D116B5" modified="2016-09-07" version="1">MIPNDTNSCCVSEGINESYEYQRLKYAMDAVGFSKQSQQNIFAVISAVLLLGNIQYARRSGYHSDESVYIDNEEILEPISSLLHIKASNLQQALSVRRTVMKNDVVVSQYNLSEVSSISRPFSLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKD2</accession>
    <name>A0A183HKD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7942</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008637">
        <property type="protein sequence ID" value="VDO53274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKD2"/>
    <dbReference type="STRING" id="387005.A0A183HKD2"/>
    <dbReference type="WBParaSite" id="OFLC_0000794301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000794301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000794301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO53274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000794301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20141" checksum="21B90C787D1BD18E" modified="2016-09-07" version="1">MENEVLLVYGHRLISLLLAVDLGWEWVARAFNVELFENESMMLRFSIIMEDVKTEQSEIVAEEGAETETKAETAAETAAETEVEETSVKTATNKEVDPNMSNYIRLRGLPFSAKEDDVRAFLKGLEVRSVTFTLTSMGRASGECYVELVDKIAAEEAKRFDKQEMNNRYIEGYFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKL5</accession>
    <name>A0A183HKL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8024</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008782">
        <property type="protein sequence ID" value="VDO53703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKL5"/>
    <dbReference type="STRING" id="387005.A0A183HKL5"/>
    <dbReference type="WBParaSite" id="OFLC_0000802601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000802601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000802601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000802601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25097" checksum="EB295F046BEC04C9" modified="2016-09-07" version="1">MKFKNSSKSDRLLNKMDEREILTADTYDLHQTICVFTYSACNYAIKDDNEQTIPIFHLLKYDCWPRYLRAGGVAPTFDDSPDETTETPTTSDSTFRKCRGDKKRKSLIWHGLKPRFSRWKKTWSDADDSLERNCDHRSSLQETTKQYTSPQFSKSQFSSRHSLTQVQLESSVYTGNTRDPLFVKPDSELRIGTLSKHGSIRRRGFAAAGKHRLLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKW8</accession>
    <name>A0A183HKW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8129</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008961">
        <property type="protein sequence ID" value="VDO54145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000812901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000812901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000812901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000812901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25800" checksum="3A78E67E14076CC0" modified="2016-09-07" version="1">MPLLDNLWRQNIMDMKSFIVLSIVLYQAISINITSTVEVIDEKSNESAIYDYRKLFITTPVQNAISKYLTREDLKTVTTINEMASFANSELNRRLRILHFRYGKIMPSTQEALNYLSRRNSIDMRHEEWVADTCILFGDKDPMNITGMLQNNLIIAIASRKDHLKVEWNFDKINEFASNDGEGTLINGMIYPCNCIPCGEFPMSCLPLEDIKFEQFILKIQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL39</accession>
    <name>A0A183HL39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009089">
        <property type="protein sequence ID" value="VDO54538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL39"/>
    <dbReference type="STRING" id="387005.A0A183HL39"/>
    <dbReference type="WBParaSite" id="OFLC_0000820001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF334">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="22392" checksum="7D7AEA2FE4BF897B" modified="2016-09-07" version="1">MEGENGCPRGPTGPPGEPGIKGENGLDGLPGKDGVPGIAAVPYAIPDKGPCAPCPPGRPGLRGYKGQRGLRGPIGKKGEAGTPGRDGMVGEEGPEGEVGPAGPQGLPGEKGLPGLDGYLYIRGPPGEKGEPGPRGPEGDQGPPGERGDQGEQGLPGKPGRPGQPGPEGLIGVPGPDGQPGPAGADAEYCPCPSRDGKGHGTYEQTEKPPAYEQTEKPPAYEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLB1</accession>
    <name>A0A183HLB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009221">
        <property type="protein sequence ID" value="VDO54902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLB1"/>
    <dbReference type="WBParaSite" id="OFLC_0000827201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000827201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000827201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000827201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15434" checksum="01A459AC1AAE8DCD" modified="2016-09-07" version="1">MARYRRRRFVGRRMRRRRYRYGARVSRDITFASGCFDLQAGGRSHPLFASSFGLPTDCPVKIYGAVVWMATNKDCSPGVLRVQVGGGDKTDVVASRLTCITAGIVRRMWLRMPSHVDYHLFLPTTAVISLAHGTEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLK0</accession>
    <name>A0A183HLK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009393">
        <property type="protein sequence ID" value="VDO55309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLK0"/>
    <dbReference type="STRING" id="387005.A0A183HLK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000836101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000836101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000836101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000836101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15065" checksum="81C12E61A82EDAC9" modified="2016-09-07" version="1">MLEAINILNQAATVAQFLRAPTWHVEAMNFPRYGYTVHLNPELQITHVATSLLEPNPQQQISPSSVLYHAVPPCIVPVSNSSQSLTAVHGLDTYADVNLLPFPTSDDIFVSTAFIEHLIEIGRIDVYALDKHGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ58</accession>
    <name>A0A183HQ58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9624</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012007">
        <property type="protein sequence ID" value="VDO61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ58"/>
    <dbReference type="STRING" id="387005.A0A183HQ58"/>
    <dbReference type="WBParaSite" id="OFLC_0000961901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000961901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000961901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057339">
        <property type="entry name" value="RBD_SIN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25322">
        <property type="entry name" value="RBD_SIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Target of rapamycin complex 2 subunit MAPKAP1-like Ras-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000961901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18596" checksum="3DD8D8FEDA1EEF3F" modified="2016-09-07" version="1">YTISGKQYEFSIDSPEVPLRWLRDQAIKKRIEDEGQEFMSDCTALREYILETVKQPDIVLDLNKPISSVACSEFLLLRVNSSRGDFSPTGCSNFAEKHSSTSKIYDDLISSSSLERQQYFDMTQKKHSRTSTIANISSLSSFDITDSLGKSIAFYPVEKIHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ92</accession>
    <name>A0A183HQ92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9649</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012068">
        <property type="protein sequence ID" value="VDO62167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ92"/>
    <dbReference type="WBParaSite" id="OFLC_0000965301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000965301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000965301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO62167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000965301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18825" checksum="AFB1EF9114C05875" modified="2016-09-07" version="1">MLLFVITKYSTVLMIITILVIAETQRITLNFNILSFNNNTAGDNSLNNNGNAVESSSSARETSTKIKQTKKNKKDYDSSYDYDYYDEVSTRRTPCGSLSISCGRVVEYPTSESVEVIEVHISQKRDVSHISQKRDVSHISEKRDVGHVPIYRKYDVVDLPIFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC5</accession>
    <name>A0A183HQC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9688</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012156">
        <property type="protein sequence ID" value="VDO62485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC5"/>
    <dbReference type="STRING" id="387005.A0A183HQC5"/>
    <dbReference type="WBParaSite" id="OFLC_0000968601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO62485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="22597" checksum="888C9E80D67D0594" modified="2016-09-07" version="1">EERKKEVEAELGEQLKERSKEHEKHKYQEHEESFKALLIDLIKSADYTWHEARRILRKDSRYENCDLLEKDAKERLFDAHVQHLERKRREVFFQLLNETKDITPSMKWREAKKIIEKDERFTKFNISERKTERDYKEWMEERKEAVMKDFKDLLKETKIITYKSLKMIQENEQHLRDILAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQH0</accession>
    <name>A0A183HQH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9729</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012253">
        <property type="protein sequence ID" value="VDO62836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQH0"/>
    <dbReference type="STRING" id="387005.A0A183HQH0"/>
    <dbReference type="WBParaSite" id="OFLC_0000973101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000973101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000973101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000973101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6874" checksum="CA601BC2047753A5" modified="2016-09-07" version="1">MTAEMMQRCNVNFCWPLSINRTYNSQLIGCSVDDGAADTVIYDELMHRVIQEVHQVQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRM4</accession>
    <name>A0A183HRM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10135</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013218">
        <property type="protein sequence ID" value="VDO66135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRM4"/>
    <dbReference type="STRING" id="387005.A0A183HRM4"/>
    <dbReference type="WBParaSite" id="OFLC_0001013501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001013501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001013501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001013501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19391" checksum="2285396A2300D025" modified="2016-09-07" version="1">MRKKKLAISPLLFAPFGDPPTVFISEDYSNRKEISTVEVKMVPEPLLLNLAHSDSSFLTFSSDNLYGYSENDSDEPNAVFENSASRMNIPFFLDNEHFYGYFFDHSLRSLDFQRKALRYLLADWIANSGLMPIVHSSFLAVTYPRPSLFDVDKIYLINLERRNERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSI3</accession>
    <name>A0A183HSI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013939">
        <property type="protein sequence ID" value="VDO68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSI3"/>
    <dbReference type="WBParaSite" id="OFLC_0001044401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001044401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001044401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001044401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18662" checksum="850BF48BF5A07D00" modified="2016-09-07" version="1">MDKTDFCPQVRHYKGEMIASEAISIKFHVPKRSTLSPVVHTLYDNSFYSSIYQPIAINIDGSWLDFLRTQQIIFTCDCLWHPIYHPYESDLPTRIRTIATTRNPAHPFDLEPNFAQIEIVVQPPELFLSGFACWIIKNYINDYFILYYQVRYNTILFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT51</accession>
    <name>A0A183HT51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGM_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014445">
        <property type="protein sequence ID" value="VDO70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT51"/>
    <dbReference type="STRING" id="387005.A0A183HT51"/>
    <dbReference type="WBParaSite" id="OFLC_0001066301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001066301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001066301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF6">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE B HOMOLOG DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001066301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13761" checksum="804247AA620BBA33" modified="2016-09-07" version="1">IVKKNERCTSRKQYEAGSEDEQLPNSFTDGSIFVGNTGRKTVEIKAVNQTSVEIMLRYIATKISIRRHGAYLSVALRIPERIVQACCSRGEVVKLEEALANPISFTRCHGVRMKIPLKLAIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTP3</accession>
    <name>A0A183HTP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014945">
        <property type="protein sequence ID" value="VDO71826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTP3"/>
    <dbReference type="STRING" id="387005.A0A183HTP3"/>
    <dbReference type="WBParaSite" id="OFLC_0001085501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001085501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001085501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001085501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19533" checksum="968E19B9B309F2B0" modified="2016-09-07" version="1">MVQRDSLCAPEIDIFRAIREWIRQHPDQQEDAQMIVARLRLSLIKLDDLLNIIRPSGLVVSDAILDAIKERSEKKSGELPYRGFLLPNVNVMSSSFNATVLSGEGSTTLLSGETNRYDMERGFTTHAIGDKNPGIIIQLGRPFIINHIRLLLWDRDQRSYNYYVEVNFTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU29</accession>
    <name>A0A183HU29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10994</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015310">
        <property type="protein sequence ID" value="VDO72966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU29"/>
    <dbReference type="STRING" id="387005.A0A183HU29"/>
    <dbReference type="WBParaSite" id="OFLC_0001099101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001099101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001099101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO72966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001099101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12378" checksum="662E4C4486AD23AD" modified="2016-09-07" version="1">MAPICDLSDQRLLLLPDKLFSVGVNRQIVTLNLRRNSLQFRPSNQIQNTLLGWLDDIERLRSLRSLNIADNSLYHFPIAVTHLSNLTELILSGNRISYIPKQIAELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU45</accession>
    <name>A0A183HU45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IstB_IS21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11010</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015344">
        <property type="protein sequence ID" value="VDO73074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU45"/>
    <dbReference type="STRING" id="387005.A0A183HU45"/>
    <dbReference type="WBParaSite" id="OFLC_0001100701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001100701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001100701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001100701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12600" checksum="520D31AC17166424" modified="2016-09-07" version="1">MDCLFPRSTIDLLLKALLQNRRLVLFGATGIGKSNLARLLARYLCIKVGGTLQNTIADIKIGDDDNDRNMAQVRKIDIDLKFSFSFRFSGFSAYRFLSFENIVFLFGNILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUA2</accession>
    <name>A0A183HUA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015493">
        <property type="protein sequence ID" value="VDO73488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUA2"/>
    <dbReference type="STRING" id="387005.A0A183HUA2"/>
    <dbReference type="WBParaSite" id="OFLC_0001106401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001106401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001106401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001106401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8798" checksum="1CAF8171360620A9" modified="2016-09-07" version="1">MEEIVEAIHDMIGNVIDLPKNEDTPEKRVAKIFSSMDQNLDGKLTLEEFKIGSKNDPCIVQALTTDLHKNSVQSTHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV91</accession>
    <name>A0A183HV91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11401</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016424">
        <property type="protein sequence ID" value="VDO76151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV91"/>
    <dbReference type="STRING" id="387005.A0A183HV91"/>
    <dbReference type="WBParaSite" id="OFLC_0001140301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001140301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001140301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO76151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001140301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18778" checksum="9A41AB9574D09B59" modified="2016-09-07" version="1">MVMETIENIVSLMGANEIDARLEEQLIDGIVYAFQEQTQEDAVMLDGFGTVCKGLGRRTKPYLPQICGTILWRLNNKSAKVRQQAADLIAKLAPVMNICQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRYLLIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVP9</accession>
    <name>A0A183HVP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11555</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016811">
        <property type="protein sequence ID" value="VDO77333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVP9"/>
    <dbReference type="STRING" id="387005.A0A183HVP9"/>
    <dbReference type="WBParaSite" id="OFLC_0001156101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001156101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001156101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001156101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18331" checksum="B85437CB9C3AB1EF" modified="2016-09-07" version="1">MVWGERAKDNYEKLRQLGEALHTKLTADQVLDYLDPKLMWNTLLQSEQTTNIKMPEKNSNHFYDARFILRLLATLIDHGTKMNSRKFIDVNGLSLAFAATSFVNRSERCVAYLVLRRFLLHLTELNADSFPEKCLYIYLLQIFKNSIENPIQRLPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY72</accession>
    <name>A0A183HY72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12434</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039842">
        <property type="protein sequence ID" value="VDP11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY72"/>
    <dbReference type="WBParaSite" id="OFLC_0001243501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001243501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001243501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001243501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8967" checksum="B8EF5272A0B0ABD7" modified="2016-09-07" version="1">MMLLCYRTRAATVYSNTGNYDGRRRASALRSETEGGAKGYKGRQWVRERRGDVDHSADKSRGERNATQRPSGRTVEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYI0</accession>
    <name>A0A183HYI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3715 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12542</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039863">
        <property type="protein sequence ID" value="VDP11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYI0"/>
    <dbReference type="STRING" id="387005.A0A183HYI0"/>
    <dbReference type="WBParaSite" id="OFLC_0001254301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001254301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001254301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056242">
        <property type="entry name" value="PIN_TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF11">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24630">
        <property type="entry name" value="PIN_TASOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR PIN" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001254301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1124" mass="126018" checksum="D3CF4E2DF590299C" modified="2016-09-07" version="1">MVLWESDLRVDIVWGLLIHWKFCSGDEDGKLTCYQFTGNCPSQHYISDIALNCEAFRNIYQQVILSHLSNSRQDREAIRIVRCRVISNKQLEARFSNFRQSLESQWLPSDVSFGYTLLSDNLREMELIAQWGLSVNNNFVGDLGEPAYGVYLSEHPDLVTPAPFLGRTKLKILACKILKGKCNIVGLGSYHLLPKRGYNSHAALQPVDCKLSRHDNYRCDQIFLFEEKGTGYSKSPANVLPFAVYDLEFPPNTVLSFKGTDSVVWSGNLLIGNKRYSRVSLCSLAAATKPPLLDTFEITDLIHWTACLAFPPILELLKPPALGEIALKKEVLLIDSKRLVYYFTLFSEDDSHDLVLLHESMRIKQAAGITIFPSIGIFILLPNGLFSDLLTLPKTAGSIFHCLYLTSDLNCSLINGAFEAMSTDENDEFMRPLLLQERIDGLDVHVQELIRNIARNTSFSEENSNKSGIQGEISNASSEAIDMDIADSDDDEEKRGWHDERMDKIFGMETPSREHLVSTPSSKLKLSSPHSIGEAVSKDTRLLSSDPRREKVFINRDPRKRLINSQDLPIPSCSVLRRKISDSSSLREHSDAKKKSLASSSDLSATDFHGYSPSDAISSGGSSPRGVSESQRSPSSSSPNFEDSNSTVLVGSFLRNESEFDNTESPASPPHEPGVFVATAPKIISDYDMRSTTDASFQTPVRQYRPPEVTPFTALASVEAMKNPEPLVGNIDKKHEGKIDFEGIHSTSAQNNENLIVDDEPSYILPELVSFSRHSIQGNPTENKKSNSSLNPSPQHLQWDILPSSKVDNRNLSFWKTKTESVSSGDVDMRTIHKVSSVPDISREAIASTTHHVTSVMQAPIVFSNGDTDHRIISSAVRPSTSAQPPECFTNESSGHFHIHPFSSFTPLPSTEAFQYHNTSSTNYTSGFKQSHMYGFFNQPTIHRQPKPYYAQDVRVSLLTMGGSSSINFQKRGVLMIDDAQFTIGALDSKFFRMILERFSNWRKNSSILWWVKLHEHLRQTLTSDSVSSNSNPKIVEKYAHYEEIIKEYENLKVIQTMKSHECDRSKHDTNLLLKCLNHTASTNRKCSMIYLTDIAKDSLMGKQIADTGFEIYCCAELSKKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ61</accession>
    <name>A0A183HZ61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12773</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039928">
        <property type="protein sequence ID" value="VDP12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ61"/>
    <dbReference type="WBParaSite" id="OFLC_0001277401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001277401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001277401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001277401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9838" checksum="EF59EA4AE129C929" modified="2016-09-07" version="1">MAHFIKKIVDRTRSRSKSPVKYHRNDYEQWKEMQHPQHSSHMVTSMRTYDYFVHPTYDQQFQNFHASISFCLNGNSINLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ67</accession>
    <name>A0A183HZ67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C-mannosyltransferase dpy-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12779</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039930">
        <property type="protein sequence ID" value="VDP12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ67"/>
    <dbReference type="STRING" id="387005.A0A183HZ67"/>
    <dbReference type="WBParaSite" id="OFLC_0001278001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001278001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001278001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF3">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001278001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="614" mass="70986" checksum="F870F1EFDC3F1E6F" modified="2016-09-07" version="1">MDYEICKSAERIPLSSYRILYNRLNVNFNAFMNYIGFLFALLCGFIFGKYMQELHETKLWFSHIEQVEQEISLRTEAGLYYSYYKFAVHPQMSLNNIVYALMHDNSWLYGLLVFTWMLANIDDSTRVFFTVNLRENFALPFFWLQNACIVVVLRLSDTACKKYYFIFFFSTFLFALFWQFNQFILVLQSISLVGMSLIIPHLSSIVTSFLLLQSQAFFLVVLAQFGQPMNITSICTAFNLSSIVILRLTAKTERNQMNIILLKSVCIVALTLSLSWFIRYLVDAEADTHIWTFVKAKIGLISRSSVPFESALYLCHGAFAYLDSDFFWRTSLNGCFPLFVTAILIVTVMTAYSVMLQCCDREFVPALIDHFGPEIIFIIIQSVLCGIIAVFTLRMKYLWFPQIAVVACILPVMISKFSGRFIVQVVVIAAITAILYNHYGIYKEQMANEQEFYDPDTVALMEWIKRSTQPLTSWSGSMQLMAGVKACTGRYLANHPHFEDKWLRDRTLQLYQMYGRKTLSEMHEILTAHKVDYIILEDSICLATSTGCSTKDLVDAANGDTPEYAMPKKIDPKNLSIKLRFCDRIRYADYETRLYFKLVFENPTFRVYEVLGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH0</accession>
    <name>A0A183HZH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein 1.8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12882</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039963">
        <property type="protein sequence ID" value="VDP12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH0"/>
    <dbReference type="WBParaSite" id="OFLC_0001288301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="23754" checksum="17E3EAB7843B290F" modified="2016-09-07" version="1">MGLFTYAGSPRGTYSTDDGAAGNGDGGCACEGGDGASGEGGGATGGEACVCEDGGCAYGSGDKGGFGRQHEGRVGVGGCGYGGGYGKDEGRQHEGICGCKGGYGKGGSGGGYGKGGGGGEGAAAEQHEEDCGCKGGYGKGGSGSEGAAGEQHEGGCGCKGGYGKGGSGGEGGAGNCDCEDGYEVGYGKGGNGKGGYGSGGEGAIGEQHEGARGWQHEGAGGWQHEGGEGVESGLQHGQKRFKRGLKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I081</accession>
    <name>A0A183I081_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13143</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040063">
        <property type="protein sequence ID" value="VDP13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I081"/>
    <dbReference type="STRING" id="387005.A0A183I081"/>
    <dbReference type="WBParaSite" id="OFLC_0001314401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001314401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001314401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="5">
        <location>
            <begin position="287"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001314401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64377" checksum="05003D4ADA528E13" modified="2016-09-07" version="1">MSQFGCVVIDEVHERTLYTDLCLGMMKKILRLRPDMKLVISSATLDAEPLLNYFAEFQAKKLEVPGRQYPIKICYEPPNSGCKGLKSLMRDYIDRTVEKVINICESEAKKQPFEDISWKDSLETHAAHIMAFLSKYDDELIPHETLIAEECLTKRLAELKHNVQVKIMTLYGNMPVEDRVEVFAPLEPEYHHKVKKFDAVRQTNILELGLISKTAAKQRAGRTGRTAPGICYRLYSEEQYEEMETTNVPEILLTNFAEVVLYLIAAGITDPAEFDFIEKPHSSILMRSQALLRSLKAIEYRGTKLVLTQIGKKMKQLPLEPRLAKMVLDSMEYNLVVETAVVCACVHVGSLFHRGNNQNKFILADQKKLAFCEDSGDPMTSLVVFHQYIRTPKDRLKHWCFENYVNSKRMKSVFNTAYKICNVVSHFTGVNADINKIDISKARTIIPSLFCRSFGSNLAIYSGLPERGYYDFNEKKYVFIHPSSALKYIDVTPEFIVYECSVYTSNDFILNVCAADPSWLNDMDKNVLEEKRKNKLVPYNIKCGTVIKKWIMAHMDIIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0S2</accession>
    <name>A0A183I0S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13334</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040149">
        <property type="protein sequence ID" value="VDP13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0S2"/>
    <dbReference type="STRING" id="387005.A0A183I0S2"/>
    <dbReference type="WBParaSite" id="OFLC_0001333501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001333501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001333501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001333501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9061" checksum="9C6A8779FD075713" modified="2016-09-07" version="1">MSVLIGNIRQCDCIESGCVGHMSMHLLYLLIGPQNPQRTNLDSEMANLKNQPDKCAIAKRRKENKKAKEAKNSYVVESKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1R7</accession>
    <name>A0A183I1R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SHNi-TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13679</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040330">
        <property type="protein sequence ID" value="VDP14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1R7"/>
    <dbReference type="STRING" id="387005.A0A183I1R7"/>
    <dbReference type="WBParaSite" id="OFLC_0001368001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001368001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001368001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001368001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30005" checksum="4C7875C4933A83D6" modified="2016-09-07" version="1">MEDEEEEGKNKVEDEEEKDGRLDEDNKDGISEENDSKDGSEAGDVEYLQLAWENLEVARTICDKHLEEEGWKEKKVEVLLDLADCSTDAENYKQAIDDIDACIILSESIFDEVDRRIAQAYFIKGRTHNLAKDFGNAAKVFGKSKEILETRLAKLETQLTYENQEEVEKIKKEIDELKSLLPEIQMKIDDSLESARSLTKESVIVEDNEGEISLKSSIKEMPVDDVSNLVRKKLKRPAGNETQKKTKRPKDGDDPVNIEVDSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1T1</accession>
    <name>A0A183I1T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13693</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040340">
        <property type="protein sequence ID" value="VDP14419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1T1"/>
    <dbReference type="STRING" id="387005.A0A183I1T1"/>
    <dbReference type="WBParaSite" id="OFLC_0001369401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001369401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001369401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001369401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12404" checksum="D3ADB49739CF172A" modified="2016-09-07" version="1">MECSFAPEFRNRTRYEPSWTVVAGDLPRHLTRNGVSFSKQHYELLQTSGAYNLQIRHVVFRRDNGKFFCTVLDKESGAQYTVQANIIVVGLFSCMIIRIFFSNPCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1X8</accession>
    <name>A0A183I1X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13740</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040368">
        <property type="protein sequence ID" value="VDP14537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1X8"/>
    <dbReference type="STRING" id="387005.A0A183I1X8"/>
    <dbReference type="WBParaSite" id="OFLC_0001374101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001374101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001374101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001374101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19447" checksum="829B975309BFA3E3" modified="2016-09-07" version="1">MPCLLPCTCTVVALTFAIYMLRPFYPNCEPPGGLPALLAIVLLIILTAINCMSIRLATFVQDFFTVAKLFALCLIIGTGALLLISGKPQYRESFENIFENTTPDIGTASLAFYSGLFAYQGWNYLNFIVEELQNPTRNLPLAIAISCTICTVIYTLTNVALYTVITPDEMLSSPAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I223</accession>
    <name>A0A183I223_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13785</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040393">
        <property type="protein sequence ID" value="VDP14643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I223"/>
    <dbReference type="STRING" id="387005.A0A183I223"/>
    <dbReference type="WBParaSite" id="OFLC_0001378601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001378601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001378601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027844">
        <property type="entry name" value="INTS15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14540">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14540:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14964">
        <property type="entry name" value="INTS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001378601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12352" checksum="B66AC6D3B30F858B" modified="2016-09-07" version="1">MDRRGSSQSSGVGAASPRKHQSFPACVTDVLEQVTKVCGQQGQKWRGPAALRNNELQYQLDNDLFCISPDRRVSRLNQIQQLRLMQILCDYFRVRFFFASISPFIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2F7</accession>
    <name>A0A183I2F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13919</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040468">
        <property type="protein sequence ID" value="VDP15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2F7"/>
    <dbReference type="STRING" id="387005.A0A183I2F7"/>
    <dbReference type="WBParaSite" id="OFLC_0001392001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001392001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001392001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552742" evidence="1">
        <location>
            <begin position="20"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="3">
        <location>
            <begin position="283"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="4">
        <location>
            <begin position="428"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001392001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63997" checksum="9F15F297A88C6D43" modified="2016-09-07" version="1">MKSLWIVIILSALPSVIDSAVKKKSVITSLHAKWSQTSFIAEASEFMAQESDTLFWAYVDEIVEKLNVDEWHTYSDARQYELAIRLAGNLLEEARVNLLKFALSLRAHSPTVVLFQKLGAERDKSCTAFADVHGAIICDVNDLEKVIENGVRGSAPTVYSIDHVFPTTKEHNVTLIVYGELATASWRKFHLVAKALSRRGKDVRDDKLLLSGYGVELAIKSTEYKAVDDSNTVIDKITVEESSEEYTDNEEGNYGFNFTTLRKLHGDLKDSIEQFRLHLLERDELTPLKVWQVQELSYQAAQTVVLAGTQKALNVLIDSSQNFPLAARSLSRQLVRKEFISEVNTNQEQLIEYGVSEGESVFFINGIMVDVDALDVFQVLDMLKQEEKLANGFFRMGIKNEYLSMLMDLESSNEHISYAVDFRPAIPEYLNNLDTDKQYRQWANSVGLLLQPYFPGMLRPIARNFFTLIFVVDPSQKETRDLLQYALRFYAHEIPIRLGVVFVVNDEKEVSGFDDASVAMLNLYNFVKINDGIQKAMNILTEVKNCQVFFFFFDGLIPNPCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2K8</accession>
    <name>A0A183I2K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SUMO-activating enzyme subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13970</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040507">
        <property type="protein sequence ID" value="VDP15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2K8"/>
    <dbReference type="STRING" id="387005.A0A183I2K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001397101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001397101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001397101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="11">
        <location>
            <begin position="320"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001397101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44655" checksum="EB2B4E140F6408CA" modified="2016-09-07" version="1">MTWQNKQFLEVLQCPVLVVGVGGIGCELLKNLALTGFSNIEIIDLDTIDVSNLNRQFLFRREHVGKPKAIIAAEAVRSFAPNVKIVCYHDSVLKEEYGVDFFQKFTVVLSALDNIAARNHINRLCLAARVPLIESGSSGYLGHASLFIVIVRPIIRDYTECYECNPKTVQKTYPGCTIRNTPSEHIHCIVWAKHLFNQLFGEPDDEDEVSPDFTDEENLDGASTNSDKNNGNTALNTGKKSEDSPSMHGDSDGFLNRINTRKWAAENGYDPKILFKKFFHDDINYLLSMTNLWKQRRKPFPLDWDNLPNENASSSSNEPNAELWTVMQCKIEFETAVSTLSKLVKDGSVLLWDKDDDPAMHFVAACANLRAHIFSIPLKTLFDIKCKFLEGILAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2M1</accession>
    <name>A0A183I2M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13983</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040515">
        <property type="protein sequence ID" value="VDP15186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2M1"/>
    <dbReference type="STRING" id="387005.A0A183I2M1"/>
    <dbReference type="WBParaSite" id="OFLC_0001398401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001398401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001398401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP15186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001398401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="45390" checksum="D123A2A6EFAF5E2C" modified="2016-09-07" version="1">MTSEMTSINCASEGINEGKNSNTAVEESNESVEYVIVSETEDSERLELPLLPEDCSLSLNTLVHAFPGAHGLKYKNSTTGASRALLMDPQGTRFLAPPDGWKNKTFIVIYPHRGSGMYLCEQEGDSEDSQGGRGGQFTAKQKRIEDPSGEKACIDLIVLGLPFKTSAETCKAYFENFGEVGDTGSPVVTRIFVGRVQEKTTVDTLRKFFNGEAAKIDPNAFVTDVFIPRPFRSFAFVNFSSAAVAKELMRQGDFIIDGSSVAVSAAAPRESDFSPRYGQSASYGLPSQGRHSRRFSDKYGYSPETVSFKSPDYTSYPYDPMVSRSVDNWRASTYRSSDTRASNRFSPGYSNSPRYSTPARSGTSQALASGLDALNLNKMNVNPDMMDAAWQAFWSTLSNNSGNGGSGTSATNSSGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2P7</accession>
    <name>A0A183I2P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14009</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040532">
        <property type="protein sequence ID" value="VDP15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2P7"/>
    <dbReference type="STRING" id="387005.A0A183I2P7"/>
    <dbReference type="WBParaSite" id="OFLC_0001401001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001401001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001401001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001401001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18422" checksum="C562A7ECFEC8860F" modified="2016-09-07" version="1">MLRRTILDWSIQTYSLQKVLILQLCAAAVVSVSRIYHPQHCSNDTDVIDHLLTEAALRHNRHKLPSRPVIVRIEMWIQEVTYVSELTQDFEIDLYVNEFWEDPALNYEVLLPCNGNLSFDHSIQEIIWIPNTCFINSKKALIHSSPFRNVFLMVFPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I399</accession>
    <name>A0A183I399_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0183 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14213</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040678">
        <property type="protein sequence ID" value="VDP15998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I399"/>
    <dbReference type="STRING" id="387005.A0A183I399"/>
    <dbReference type="WBParaSite" id="OFLC_0001421901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001421901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001421901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001421901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44129" checksum="857579A16C306563" modified="2016-09-07" version="1">MLQVEVMPGCGVRNDYIELLLGMPINQAIAAIQNASRHIQNVELTYSSKEPLSRDVMIRLAKDGIRLYFEPNTQLLRLIEVYDLSNIILQYGGVVFSSPKDEADVNKVEGCFGATHPGVYVAEQSLYELSWKGLSFSFPTLNETSKVQTSSIDATGLGSLQFRSNSPPLLAKMSIYPDTYNSPKPPKISAASLCGVICPVEVKSISDGSKISGLFFIFAAETPLADSSSRKQAFGLRKIERSIFFGDTSESVLSSLGAPSKVFYTKADRMLIHRGEDSKKLRGPRPNYFFNYFSLGIDILFDCITNRVQKFVLHTNLPGHFDFGIYARCNFCIAVTGGPIITPSSKRENFLGAFCGDTTVQPVVLSRSGTENPFGSTFCYGTNQIIVEVSCFKNQLIVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4G3</accession>
    <name>A0A183I4G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14625</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041016">
        <property type="protein sequence ID" value="VDP17927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4G3"/>
    <dbReference type="STRING" id="387005.A0A183I4G3"/>
    <dbReference type="WBParaSite" id="OFLC_0001463601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001463601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001463601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001463601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30390" checksum="0DCDE0C3DBC740EA" modified="2016-09-07" version="1">MLKCRSIFTESYPSHISQRFSSSDGPMFCNKKLRVITLDALNTLIRLKQSPGHTYADFAKHFNIQCSGDELNEAFRRNFRTLSKRKLCYGFRKDGEVAWWIELVKNCFADIGKKSTEIDKLAHKLFVYYGTVEPWRLVDNQVRDHLKELQNRKIRLGVISNFDSRLRTILDGLNLSSYFEVMFLSGEVGIEKPNKQIFEKVAKYFQISEMEEILHVGDDEEKDFNGARKAGARAVLLNPDKVSCDNKKYILCSLKDIIDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4U3</accession>
    <name>A0A183I4U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041162">
        <property type="protein sequence ID" value="VDP18607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4U3"/>
    <dbReference type="WBParaSite" id="OFLC_0001476601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001476601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001476601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001476601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32614" checksum="BF1E386968534D6D" modified="2016-09-07" version="1">MSFNPKFREIKVRKDVEAGGSITMESIDESQATSKKSSDKQKEMSRDESIDSVRKKSERLQRTTSMKPGISETSEEFELQNRPNSPSRKSLFSSEIERLEPASLHLATAMYPARKLEAQITTKTPLLKKISQDIKEEIPTPSSPSSSRQQQQSTPLIGNGPVSSSISGRPLANHIGALNEKEKSRKTSNTGSSQILILQEALKHGLASTKQQLMQTSETLDGMRNLRYMESEKQKLSDPKVLAKLTKLPTFMSRMDSSEKKQESSTIPGTSLKSPNGSSTVSGQNLEGRKGDTGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I572</accession>
    <name>A0A183I572_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14884</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041320">
        <property type="protein sequence ID" value="VDP19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I572"/>
    <dbReference type="STRING" id="387005.A0A183I572"/>
    <dbReference type="WBParaSite" id="OFLC_0001489501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001489501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001489501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001489501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14162" checksum="89635569FD105E5F" modified="2016-09-07" version="1">MVVQNIWQSGTNWDDKLKMQDRYQCEKLTEAFIDAPEITVPQWVPKENRDLHVFVDLRYGQSGLRMIYGKLILVPKKGANNKSAIIPRLELLALGTRIIEFLRQESEVKDAYLWTDSTCAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5R0</accession>
    <name>A0A183I5R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15073</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041573">
        <property type="protein sequence ID" value="VDP20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5R0"/>
    <dbReference type="STRING" id="387005.A0A183I5R0"/>
    <dbReference type="WBParaSite" id="OFLC_0001508301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001508301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001508301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001508301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29393" checksum="63A62DC35B7F4F84" modified="2016-09-07" version="1">MGAGAACASILAVSPKTKGKFIQISSDHYMKNGNWDLSYVIPSYLHANYKQVQKAVEYQYLNDYPQNLNEAERRDIILNILSDQHFVAPAAREALLYARKNLIVYAYIFQYENAQLLASVRKNGASHGNDCSFIFNNPTLSGSSLKTIEWNDDDRKIIQQLVSQMVNFIRKRNLSEDGFERFRTIYRIATLISNRNITDPVEFYSNVTEFWHKIIPTVEQLHIAPQYRVLLQPCTMCQYPYKIPFYIILTVLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I788</accession>
    <name>A0A183I788_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xpo1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15600</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042434">
        <property type="protein sequence ID" value="VDP22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I788"/>
    <dbReference type="STRING" id="387005.A0A183I788"/>
    <dbReference type="WBParaSite" id="OFLC_0001561301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001561301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001561301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001561301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32803" checksum="80AB723FB2B78E5D" modified="2016-09-07" version="1">MADIVGASKVNDNLCLNNMIILRLLSEEVFDFDGEMTQAKAHHLKKTFCSEFQAVFNLCYTVMESSDNAPLVDATLHTLHRFMSWIPIGYIFETNLIDLLTKKFLGVAIFRCITVQCLSEIASLSVAQMEQQNPLYINQIKSLFRNSMMQITNTIDPAVDLADAYRRGTDADQKFIANLAQFLGTFLKENSQLVEVFGDKLDQKSAVELDLKNAHEMALQYLLKISMVDDVEVFKICLDYWNWLCAELYREFPFQIDRPIISAFPMFVGHQEPPRRLLYNNVLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7E3</accession>
    <name>A0A183I7E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042556">
        <property type="protein sequence ID" value="VDP23073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7E3"/>
    <dbReference type="STRING" id="387005.A0A183I7E3"/>
    <dbReference type="WBParaSite" id="OFLC_0001566801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001566801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001566801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001566801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14357" checksum="478469FFB0D8C55C" modified="2016-09-07" version="1">DAGADAIAQKWFNWLGETFPSVVISYLNKPFNDVRISSLRLLLALFDHPWAIRIFYSSAGFLISILNRGTENNAEGKQYKYDVICKLIDSADSAISPEDMIRLKMYRREGAFYVERNPQVDMEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7J8</accession>
    <name>A0A183I7J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15710</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042687">
        <property type="protein sequence ID" value="VDP23382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7J8"/>
    <dbReference type="STRING" id="387005.A0A183I7J8"/>
    <dbReference type="WBParaSite" id="OFLC_0001572301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001572301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001572301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001572301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15708" checksum="AC5862DBDCE4A166" modified="2016-09-07" version="1">MVKFDTVKLATGADLPLFGLGTWQSTDSIALTAALKTALDAGYPLIDTAYFYGNEAIIGKVLQEYFTSGKLKREDIFITTKLPYIAHKPDEVEEMVKKQLRDLQVDYIDLYLIHCPCPCKVCTFFLSCYLLNVDLKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I814</accession>
    <name>A0A183I814_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS15876</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043113">
        <property type="protein sequence ID" value="VDP24486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I814"/>
    <dbReference type="STRING" id="387005.A0A183I814"/>
    <dbReference type="WBParaSite" id="OFLC_0001588901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001588901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001588901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP24486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001588901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13011" checksum="A1F032BCA347EB46" modified="2016-09-07" version="1">MRCACRACRFDKCVAVGMNPKAIQCSRTGRLSSPQETPTSSTSFYPYFESDLPQQQLSTSSSMEKELYCLLPQTTDSNRKRSSTSPDSESASKRAYTISALLGFPESESISTADENSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UPE6</accession>
    <name>A0A3P7UPE6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001586">
        <property type="protein sequence ID" value="VDO33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UPE6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="186" mass="22601" checksum="58BE4CBD541F4E12" modified="2019-02-13" version="1">MQRENPKRPHEVSSKIPVSKFRNVFANEKLERPIFDPRFDNRCGEFNDYIYRNNYSFLNEIRQREKKILMEELKNVTEENINRNRLKEALRKMKNQEKTQADVNRRKEIIREIRHENNERMCQGLPPIFKTRAQIRELLWRKKYDELKGGKKLEKYLRRKTKKQDKLFDINASVSCNDEVVLCPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UUB8</accession>
    <name>A0A3P7UUB8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002950">
        <property type="protein sequence ID" value="VDO38760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UUB8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="234" mass="27649" checksum="C9A2252932EFF378" modified="2019-02-13" version="1">MKIDDGKALKFEVVGTRNRAKEVEGQLCQSLEKLRINYADLYLIHMPTSFDVIIWMRQRFHFLRGMEDVFKKGLTKAIGVSNFSIKQIERVKSQLLRKIIMFRNRTVIFHEYSIWTSFFKFCVILGECHLYLPQFALHEVCKNHDISLTSSASFESPGRVDYEVPNREYLIERDIAVIPKSVKEHGVKENFEIFDFELTESEVKGCKNVKHCQHLFLFDYMTNHPEDPFKDERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UXK9</accession>
    <name>A0A3P7UXK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000057">
        <property type="protein sequence ID" value="VDO25003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="89" mass="10439" checksum="96543F0B102F9364" modified="2026-01-28" version="1">MSSDEEWTNSEASRLRKKDRIPSYVKANESYSDKEHFVGNSILIEGEKEPASVKDRKLGIYSALRAAKYTPKFKAIRERHIQYQFDIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W5V3</accession>
    <name>A0A3P7W5V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002904">
        <property type="protein sequence ID" value="VDO38623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5851336at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="322" mass="36702" checksum="B6C6EE664522A089" modified="2026-01-28" version="1">MNIDLPTSSTVSYFLHVYAYLIIGPILVLMNTSVFLVVMTSKALRIPYLILAVVFLSNALTGISAILIGMKRLIISTVEEQYIVHYDCVLNVPILLLTTFFLNGWSLLMSSAERFFAVAYPAYYYTHTKQVIYPLIVMQYTITIIAVTSVIPASLTEPTRYVSHFCALEDVYSSYFHVTLVSLSSCSSIFSIALMFTVATILQKKLGTEFLSIYSHNRNLIRFLKKQIRYTQTALFFCCFTFCFVVVPLIVQCIYMTDPTVKSQTIVICSTYLPLLNSFNMVAFFMYRQKDLQDAAIHSLKWLFGKEKHNVQSVTTIVRFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WAX9</accession>
    <name>A0A3P7WAX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003509">
        <property type="protein sequence ID" value="VDO40323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WAX9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="101" mass="11627" checksum="7F254465CA8C4D5C" modified="2019-02-13" version="1">MKIFFVIVWESDILAYRTDLIRVQCCVINDVCLVNPGIIRMVVENQLLHNTSHSKQNLLTSSLPQIIQNKIPTNTDRCSDQFLCPTTFIADKIHFKSNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WG44</accession>
    <name>A0A3P7WG44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006017">
        <property type="protein sequence ID" value="VDO46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WG44"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="183" mass="20085" checksum="378E4BE46D488861" modified="2019-02-13" version="1">MQERRRSQSIRGISWINQRNRQAIKEAILSGQIQVETSSQDDPFTRKNARMKPVPGRDKMTQHLNNKRDTVVSNDGEHSAISSKSTMIDLNDQKSLSQKGSIGASGVRGSNGPVSDLFNAHNFDVDIDIAIPAAVTLSSSASSLNSMDVNSRHAGLGNNRSAINRGSSRPLSLEDYKRRKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WY91</accession>
    <name>A0A3P7WY91_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010920">
        <property type="protein sequence ID" value="VDO58889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WY91"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO58889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="96" mass="11323" checksum="E8FFD751CF505655" modified="2019-02-13" version="1">MSFYLHFSEFFPFQILDFHEIKFKDYNVLGDDELREGIKKYSDWPTIPQVYLNGNFVGGCDILVEMHKKGEITDLFEKEGIKTRFSEAPGENQKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y223</accession>
    <name>A0A3P7Y223_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013371">
        <property type="protein sequence ID" value="VDO66737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="94" mass="10670" checksum="81DA69A7DE595D73" modified="2026-01-28" version="1">MPYNSLPYRIGNENAYTCQLISPHAPQFTAEQPERSCRGKLASEQLQPMMPNVSPPAFLLSMQTHKIAQTAAECFRQCEESRSILFCHPIIARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YVE9</accession>
    <name>A0A3P7YVE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005496">
        <property type="protein sequence ID" value="VDO45138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865991at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="91" mass="10301" checksum="9F57FBA150DB4FB5" modified="2026-01-28" version="1">MHNGVGLQTARGSDTNRFVQAIWQTCAVEETRGCNSEAELNEPKLKLTAEQRIQVAYGELDMDAEMDNRDTHVYIKAAMKNRVGYALFHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AD10</accession>
    <name>A0A3P8AD10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010786">
        <property type="protein sequence ID" value="VDO58642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AD10"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="47" mass="5596" checksum="7A1321C8C9FCA4D8" modified="2019-02-13" version="1">MISAIQVIRLNSEEQQQLQKRLISLQQQQSKNFQRRKLLGILPECKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ANM3</accession>
    <name>A0A3P8ANM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039927">
        <property type="protein sequence ID" value="VDP12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZ55"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF530">
        <property type="entry name" value="MSTPROX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="359" mass="40421" checksum="609CF171B4CE9A40" modified="2026-01-28" version="1">MPAFRICVFLLFLAVNAQRSQFDVDCPRLCHCNKTTVECRHTKIRGSGMFVNVRPEAYPDLDTIAITGNDIGDLAGSNIFGVNVTNRYVSLVNLSDNAISSIDSYTFRGLPAVEYFYLHDNAIERIGADPFRWNIRLRVLDISNFFSSSISFAERSRLLASTFANSVNEFNDLQELIVRDNGLIEILPETFCKLNGLIRLHLSGNKIRKFNVKSGCLQNLIVLDLSENEFSTISTHLWETLPSLTTVDISSNPLNCDCDIMPAIKELSRSPTFSLNQGYAICAAPESRKGQNIFEISDFACESNHRFVYWTLFVVLLCAAMIFSRIYRSRIKVRHLPLIAGYSKLGGENEQVISTPQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C4D9</accession>
    <name>A0A3P8C4D9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017617">
        <property type="protein sequence ID" value="VDO79585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8C4D9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22917">
        <property type="entry name" value="HFD_TAF6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="93" mass="9810" checksum="8A29C3C3A75BE6F5" modified="2019-02-13" version="1">MLIGTTNTHTSNSGAANVDAEYGVSYVKIVAESVGVAGLSDVCASQIAVQTTYAIKMVIEQAKKFAVHGRRKRVIAEDIDSALTMAGYPYVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EZI6</accession>
    <name>A0A3P8EZI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040009">
        <property type="protein sequence ID" value="VDP12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="120" mass="14017" checksum="40FBE5DCAB8709FD" modified="2026-01-28" version="1">MRSDGHFRRNCWRELKDEIWGIVGISCCLCTQNPQLNLRTDLERSILRKSAVCPNFDSMLTHHPIHFSPSTTTVVIRQQEIVSLVNPPPPFKLFEKAATFLKTIRRHENCLRNSKRVEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY27</accession>
    <name>A0A183GY27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS137</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000033">
        <property type="protein sequence ID" value="VDO24678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY27"/>
    <dbReference type="STRING" id="387005.A0A183GY27"/>
    <dbReference type="WBParaSite" id="OFLC_0000013601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000013601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000013601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000013601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26776" checksum="8CFA464F605BE193" modified="2016-09-07" version="1">MAESAFQKIIRVRSVDWAVLDESAFYEAIYADSSLPNRRFYEIESPFRMDSQASVIFEKDSVTNKNKPKRKRKHHMSSNITSDLRDVSVTLKKVLEKVVAMGAFTKKQHEPIPCSSVEASVNFNNCLARQLALTAASVPCPLSRYVKQQCIIKQNIREIPLNEEKKIIDDILNELVMWVNAEPKVMIVECKDEKFILPPFSSFIINDVCASRALIRHGKRFDFILLDPPWENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYB8</accession>
    <name>A0A183GYB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS228</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000065">
        <property type="protein sequence ID" value="VDO25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYB8"/>
    <dbReference type="STRING" id="387005.A0A183GYB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000022701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000022701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000022701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000022701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35391" checksum="A96B233EA9B8228C" modified="2016-09-07" version="1">MKKWQLGAIGCKVSTWINSTTSCASIFTLVAVTADRYLAICHTMKYAVWDSRWTLYVIAGIWMLSGMLAAPTLAIYDEILFTLDPPNGTLVARLCIATQDETMNFIIVNLLLAFTIPFTLISALYTRIFITVSSHRSFAVNAKIRDERVKLRVAQMMFTVIIVFALCWLPLHGIYSYFFLAKDYSTSTFQFASQVLRPIFQWLSLLSSSLNPLIYIVYSQKYRRAFRQLLILPCRQRYERTRSMAQSTLRSRLKSHSPDETLFWRRFNGDSKSACDIITLPSITILSTLNVSFPPQSERTRYYATTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYG9</accession>
    <name>A0A183GYG9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS279</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000081">
        <property type="protein sequence ID" value="VDO25234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYG9"/>
    <dbReference type="STRING" id="387005.A0A183GYG9"/>
    <dbReference type="WBParaSite" id="OFLC_0000027801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000027801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000027801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="724"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO25234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000027801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="794" mass="88700" checksum="91846750706438AC" modified="2016-09-07" version="1">MNDRTRLLTTLDPNEDPVTGLERVASFTNENAEVRRRHREQSQRELEESHRYKSHKNEEKEGAVSSRYESLNYEIVENELYRAEEMESDHQRKLFRQSVNRWVVCFFIGVFTAIIAAAIDIMIYYSSLIKFRLIISNLLNLCEKRMEVGGGCIWTVEFAWICYNCILITISACLVLYLSPVAAGSGISQVKCFLNGVEIPGVVRLKTLFAKALGVACTVAGGLSAGKEGPMIHSGAVIAAGISQGKCVTFSFDFHIFEQFRNDREKRDFVSAGAAAGVAAAFGAPIGGVLFSLEEGASFWNQSLTWRMFFAAMMSSFTLNFILSVFHGVGGFLSWNGLANFGVFENHSYNIWEIPIFLLIGVLGGLSGALFNFLNLKLSRFRKKYIQSKCQKLMECLLVAAASAFTGFITLFLVNDCQPIGRNPKLTEVTKLWCRKGQYSAVANLFFQSPEESVKSLFHSPANSYAASTLLIFAVEYYFLSLWTYGLSVPSGIFIPTLLTGAAWGRLIGIIVEYMFPNVTGIHPGKYALAGAAAQLGGVVRMTISLTAILVEATRDITFGLPIMLVLMVTKWVGDLFNQGLYDAHIELNEVPILGWCAPELSRNILAGHIMRRDVVTMMSKERVARVIEVLCATSHHGFPVIDEINSPSNEEEIPEYGHLKGLILKSQLITLIQKRVFCEDPDCRILVDGSELVQLSDFAEEYPTKLQLSERDGNCWLDLTPYMHPSPYRVTLNASLSSIFHLFRGLGLRYVAVVDDENKLHGIITRKDLARFKGRRTFGNYAVWELFVSDFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZR7</accession>
    <name>A0A183GZR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS727</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000271">
        <property type="protein sequence ID" value="VDO26845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZR7"/>
    <dbReference type="STRING" id="387005.A0A183GZR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000072601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000072601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000072601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="240"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000072601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="716" mass="79934" checksum="1F1AC3ED8F7E1244" modified="2016-09-07" version="1">MVQCKECWGDPFLQQNDSVQRGSTSCMIGMNPRSVASSFSCLPPTGMTTSSGNKTSMMDKLLTMLKGLPSTLPDGPVAESKILNPTRSNSLRASRSNPDIAGHSVGASRVATMNIAQYYQPASSPCPEHVLKVYRADQSFKYLTVYKETTAQNVVQLALQEFGMSSDSGSLEWALCETTVTPDGVIKQKRLPDQMNNLAERIQLNSRYYLKNNSRSEPLVPDELAPEVLKEAETHLLQLNAQILAAQLTLQDFDVFSAIEPTEYVDNLFSLESKYGWPKLADFESLFNKEMWWVATEICREKTLQKRMKLVKKFIKIARYCRDFRNFNSMFAIVSGLEKPAVRRLHHTWERVPSKYMKMFEDVLHLVDPSRNMSKYRQHLAIVSQEPPVVPIYPVLKKDLTFSHEGNPTYCEKLINFEKLRMIAKAIRSVTKLCNSPYEIGVMAQQSGANDVSDALVNMNSFDGGAGTVATMRKMGPNAMKTATQPRRKLYEQALMVRKVKSYLSNLNVVECEADLDQLSYECEPSCGSASVTRRRAPSPSPSSLSSQSSTSDQHRISAPKFGVESPHAVQKILSLAQNSRLKQGNTGNMMPISPLQSPLLSSKGIRLRNTPLPIRRVPSTSHHHSTVTTTSDVQPVDLNAESSSVTSLYAPRINSSVRQIFSPFTVSGVFIFCMVKILYSTQLKDASFIHRFSQDTHTHSQILAGVNQELDTTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H001</accession>
    <name>A0A183H001_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS811</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000319">
        <property type="protein sequence ID" value="VDO27167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H001"/>
    <dbReference type="STRING" id="387005.A0A183H001"/>
    <dbReference type="WBParaSite" id="OFLC_0000081001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000081001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000081001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000081001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="21011" checksum="5EE79B7F70820228" modified="2016-09-07" version="1">MIIAAVDEDIEDDPGRILHGVIYRFIFLLTDSSLLSSRRHRDDRERDRDSERYREKDRDRESRSRRHRSRSGSLYESSRSSRRKEERDNKDKEKRRNKKDESGMRTKEELIEEKDDDKREGSERKKEDSERSDRDKDKGKDRDRKKRRHRSDDDSPDKREKEKKTKTKDDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H061</accession>
    <name>A0A183H061_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS871</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000350">
        <property type="protein sequence ID" value="VDO27390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H061"/>
    <dbReference type="STRING" id="387005.A0A183H061"/>
    <dbReference type="WBParaSite" id="OFLC_0000087001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000087001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000087001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000131">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2/3/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO27390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000087001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34699" checksum="6E2E7D4C040E79D5" modified="2016-09-07" version="1">MTLPGFVINSDQRENVDQTTLRLNKVSPFGQLLESLRCAAIEMGIWNDDMHRDLPKRWEKHGNMIILPHNCFKHPNWRLMGPKLWHMVTELLNASRLAKKRFIEGDDFHEPHIDLLYGEDGWVEHIDGNIRFFYDVTKCFFNVDNASEKQRISEFDCHQEVVTDMFAGIGYYTLPYLINAHAKHVYAIDWNENAIEALKRSLESNGVRDRCSVIHGDCRKVIPIGVSDHVNLGVLPSSRPYLLTACKCLKSTGGILHIHEAVKISKQHNGNLKLSDKLAANSKLTRKTQKPFKSISLWLSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H079</accession>
    <name>A0A183H079_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS889</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000362">
        <property type="protein sequence ID" value="VDO27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H079"/>
    <dbReference type="STRING" id="387005.A0A183H079"/>
    <dbReference type="WBParaSite" id="OFLC_0000088801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000088801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000088801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="12">
        <location>
            <begin position="149"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000088801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="782" mass="89675" checksum="121A8F145C26CF82" modified="2016-09-07" version="1">MRIKDAMRENCNYSLALMWTQILTESNDLKTRVLCLDVIACYIDWIDLELVVNNTTIPVIINCLKNEHTCESAVSAISAMVTKGMDAEKKLLLIASLCTVLHENGSFDLKENDIDDVLRTGALICSLGCALIDCHTCFSKLGDMEKSMRCEVLLQEQADIALLCFSNEDMDASETVVEFLRRYVCVLKTHEFEKRHYFTSQMICIAMDRYKAANDVDLGNTNGEIVAEFMAYRRQLRNMLSAIGNFEPEPILMKLETSVRNICENWKQCHTNVIEATLALVYDLADLIHTNFGSNNGLITERAKTLVIEILQSTINLYGLSCINILFFEIACRYEKILQNSTDSLPMILEAFLDTRGLHQPSLQSRSRIIYLFCRFVKAHKLFLGNQAEHILAQLESFFTETSEEDYQLSKEDQMYLYESASVLIIHSSLAVERKQECMKVLGLSLLQKFSCITERLSQTKNVEEVQQLHQRCADVIGYSARVTKAFTNSYTMQYCQCTIIFIELMEIFLDKVTANNMEGLGALRQYLHRMVTCLDGEILAMLPAICNKYLDVGSDLKVMHDFLILLQQIFCKFKKRLLKIGLNITALFEILWTAQRISFDTSNENRVRDMIYYNRAFLQTILSILTHDLTIMLTDCGTEFLYKIADSLVSFMSSNDVPTQRITFQIINKLFLKLSNDGSTDFIEFLWEKAIYGGLQIPLNGYHDLTDAQCVLLQHEIYVCLQTLRSCSLERFDQCLRLFLPADFARNFRHCISSYKGKQLEKALDTQYAQLRLMKADDIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0F4</accession>
    <name>A0A183H0F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS964</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000400">
        <property type="protein sequence ID" value="VDO27734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0F4"/>
    <dbReference type="STRING" id="387005.A0A183H0F4"/>
    <dbReference type="WBParaSite" id="OFLC_0000096301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000096301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000096301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000096301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7473" checksum="C2CD81577BB297F7" modified="2016-09-07" version="1">MKMLQNIEWDYSVGQTTGLPTYLAWTCVFINLFAAMTFALGSHKHKGSRAATAEFEIEDRPIHIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0S3</accession>
    <name>A0A183H0S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-1,3-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1083</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000465">
        <property type="protein sequence ID" value="VDO28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0S3"/>
    <dbReference type="STRING" id="387005.A0A183H0S3"/>
    <dbReference type="WBParaSite" id="OFLC_0000108201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000108201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000108201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000008">
        <property type="entry name" value="Beta-1,3-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="200"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000108201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49977" checksum="1F47E5CF4C282F7F" modified="2016-09-07" version="1">FVILSQNADYDARRTSVLFDSLKKQFSENTNLHADILKTYEDLPGLIGAWAVWPMLGSLSQKYQKMEWDWLLICEPDTVVNVTALIGYLNSFDKGVDHAVGRGLIDETNTIIHHFFKYEDDEHFLYPDFASGLALSWTLLQSANVLAWEGFTIDAKHEFARLLKDKRGIRLNNTLSFCLLGHESQCITRYIPPDFQCTNKITNNDVYFAVKTFSEFHKTRIVVVKRTWAKTAKFVEYFSDMEDHYVPTVNLGIQNTERGHCGKTFGIMAYYLKNEEMSKTRWLVITDDDTLISVSRLYELLSCYDAKKEIIIGERYGYGFSTDGREGYDYPTGGAGMIFSRKAVEKIASFCSCPSIDSPDDMIIGMCARRLYIPIIHSAAFHQAQPEDYSELYLKRIRPISFHKFMDINPYEVYMKRLHEASDQIASRPLHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Y1</accession>
    <name>A0A183H0Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1141</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000497">
        <property type="protein sequence ID" value="VDO28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Y1"/>
    <dbReference type="STRING" id="387005.A0A183H0Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0000114001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000114001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000114001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000064">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000114001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="60578" checksum="D81D22BF511F1ACB" modified="2016-09-07" version="1">MSQLISTSTRIPIQTGKDGVSMSEPSTSDLSVDAKLSIPSLRGRAGQSKPVVSLNNSNTESVGLSLNDNDSLKTPTALGNTDVTLKTPTVLGSPTKGPLSAGTHVDELITPKLSLNNFSAPNNQTQAFFGEHEPLLTANIEISTILPQSSIANVTPGGAAVGSNGAQNDIRDQKATITFKGSISTSISTFGSQSVNSPGLSATMFQFSPLVEHFLQSITKSQQTNANLPLLVLDPNAKASSAADTPDLFKVFQDNKDAVNLPANGIQQLSTSQPSVSSVSGTHQVLSDYIQIGRAGVNRRTTPPPGPSGVRQNGFSSASTPNSVCSGIHCTQQQDARIRPVVSVGASELTSSPAQIHQHKYHIHQNITCTVSPIETQNSNQSNSAGAQRTSYQTCNFLTCSGVPCPSRTLQSQASISGASNIYRPDFQPKPEPADEYYSAPLSFTQSGPQYPQTNSAKVGKCSNRLLKPSSHERPYKCPIENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRAFSRSDHLTTHVRTHTGEKPFSCDICGRKFARSDERKRHTKVHTKQKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Y6</accession>
    <name>A0A183H0Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000500">
        <property type="protein sequence ID" value="VDO28419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0000114501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000114501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000114501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000114501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22479" checksum="A070652479B2EC2C" modified="2016-09-07" version="1">MNEKINWNLHGRSRDAELAEKFVNLKIQLEWSEWSSCEQGTTVRTREGHCYLRKIDPSKDVGEMIGSIFAAYDLFNWVTRLKNHMSKIPEFNVTGIRLYSGLVSKLIHEGAFGGDKIYDDCYTMRDIFFKTPKVTKRWISAIFAAFGIDDAESMLKTSDRLCLYYYNKPTVRTDEVPASVFVGTHLVDTQRCPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H101</accession>
    <name>A0A183H101_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WG repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1161</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000507">
        <property type="protein sequence ID" value="VDO28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H101"/>
    <dbReference type="STRING" id="387005.A0A183H101"/>
    <dbReference type="WBParaSite" id="OFLC_0000116001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000116001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000116001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000116001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30914" checksum="F68C6006B73EB1E9" modified="2016-09-07" version="1">MDRFGKLLFQEKNDFAKKAEPFCQVSFYENKIIYAYSEYMSGLTLLKILTLNGETISEQFVDGKIQSLSVNDSGEMFLTKRVRGNDSIIYSSDISCPSCWNEMICEDEYIFKTVCALSSDLLVVSTCTLPTNMYSRQFLRLINVTEGKVTKSFSKEGKEDGQIFFPLSIQKYGNDILVLDKTGRVQQFTQDGEFVRVAAKIDAYLGNAFVVDGNIAVIACSGIVLDRKNETICDDWLEKVPLDGTRWLPDPDFIDKKEKNATNHFQENYKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H167</accession>
    <name>A0A183H167_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1229</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000547">
        <property type="protein sequence ID" value="VDO28756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H167"/>
    <dbReference type="WBParaSite" id="OFLC_0000122601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000122601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000122601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000122601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="9894" checksum="F54D1ADB6F518456" modified="2016-09-07" version="1">MKDVKIEDCEAEAVYPLISAESNSLFALMWTQNLAALAAGAGTSASTNSFMQPLLNSTSGTLQQLNPFLQTLAVQSGIGFTSPKTNAIIPFPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3T1</accession>
    <name>A0A183H3T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPX2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2139</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001171">
        <property type="protein sequence ID" value="VDO32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3T1"/>
    <dbReference type="STRING" id="387005.A0A183H3T1"/>
    <dbReference type="WBParaSite" id="OFLC_0000214001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000214001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000214001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000214001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39047" checksum="0BB9B948A94D7912" modified="2016-09-07" version="1">MNETLPSEEPSSLEGTNTYLSKEKVEKDSNERIAEKSSEKVENGTARKTFKEKRLDSKESSSLSGSKEYVKVNLGFREATKKSSGSRELSKEISDSTEYIKENYGIQEKRIDGIKNHDKCEQNIVPTSLFQERHAAEKVFEKTTKRKSRPYFYDRIRDAIPKSLKEEKLVESVRKRTPRPFCYDESLDGVTKSLLNSIELGDDETKAVMTRSFKYPFVQPSSHTQEMSKDNRTKETEDFAENQAEESEADVVQEMEKMTDKFNLLKGDSSVFDPRDRSTANDVLSAQKLVKGENVMDFTCSYIFSKKSLEEVMKLEHKFLWRQQRHISDFRRSEAVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H497</accession>
    <name>A0A183H497_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brain protein I3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2307</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001298">
        <property type="protein sequence ID" value="VDO32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H497"/>
    <dbReference type="WBParaSite" id="OFLC_0000230601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000230601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000230601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000230601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8279" checksum="45276BB30B822EA3" modified="2016-09-07" version="1">MLLIIVSASASSQPPPIAIPRSGHCAHCGIGTISGQTDLFCLICLVLLAVCTFPVGLLFLCFIPCTVHKRCSHCRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4C6</accession>
    <name>A0A183H4C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GatB_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2337</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001321">
        <property type="protein sequence ID" value="VDO32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4C6"/>
    <dbReference type="STRING" id="387005.A0A183H4C6"/>
    <dbReference type="WBParaSite" id="OFLC_0000233501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000233501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000233501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic" evidence="5">
        <location>
            <begin position="21"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000233501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40580" checksum="49F215F1430DDB69" modified="2016-09-07" version="1">MRLWNKLFCASREITVEYRPLIGLEIHAQIMTRTKLFSGAAFDDDAHANSSVALFDMAIPGTLPVLNKTALMKGITAGLLLNCMIPKRCQFVRKHYFYADMPAGYQITQQDHPIAHSGFFEFYSFVPYKKRVDILRIQLEHDSGRTIHDLSNNRSLIDLNRAGVSLLEIVTSPCMNSALEAYCFTEQLRLTFMENDLCEGEMQKAQFRVDVNVSLGKDSIDDKGVRTEIKNLNSLRMVRIAVNNEIARQNEILRAGGTILNETRTVDRYGHTIAMREKEIETDYRFMPEPNLPPVHIKQEWIENCRLMLLKPRYLKNIEEYGIEPEVALQIAVSYYSAPHEIKPEITPNFKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4J6</accession>
    <name>A0A183H4J6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS2406</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001379">
        <property type="protein sequence ID" value="VDO32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4J6"/>
    <dbReference type="STRING" id="387005.A0A183H4J6"/>
    <dbReference type="WBParaSite" id="OFLC_0000240501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000240501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000240501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000240501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24806" checksum="438EF35367A66678" modified="2016-09-07" version="1">MNIFRLTADLAHLIAIFILALKMWTTRSVAGISGRSQLLFAAVFTSRYLDLFTNFISIYNSAMKVFFLISSFGTLYLMWIKFRATYDRNHDTFRIEFLVLPCVILALLINHEFTVMEVMWTFSIYLEAVAIMPQLFMLSRTGSAETITAHYLFALGSYRALYILNWIYRYYTDGFFDPIAVISGIVQTVLYADFFYLYISRVLRQKRGLQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Y9</accession>
    <name>A0A183H5Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001793">
        <property type="protein sequence ID" value="VDO34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0000289901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000289901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000289901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000289901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7159" checksum="8D2A0F57E8962481" modified="2016-09-07" version="1">TNYPAERAEGPTDRPEVSSVHRSICPRRFPLPSFLSGGAAVCYLQQQINQSTVLAFSFLHAVIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H684</accession>
    <name>A0A183H684_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YL1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2994</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001872">
        <property type="protein sequence ID" value="VDO34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H684"/>
    <dbReference type="STRING" id="387005.A0A183H684"/>
    <dbReference type="WBParaSite" id="OFLC_0000299401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000299401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000299401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000299401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10085" checksum="3C4FF49EFD09B7B7" modified="2016-09-07" version="1">MKQEPEGGEELKEEVENMEIDNDRNDESNEEDDDESGISSSGEESVELMVTTREKRSNAGNKMAQLLESAEQEDEFYKNTYNGGFLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H710</accession>
    <name>A0A183H710_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3272</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002137">
        <property type="protein sequence ID" value="VDO35908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H710"/>
    <dbReference type="STRING" id="387005.A0A183H710"/>
    <dbReference type="WBParaSite" id="OFLC_0000327101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000327101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000327101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000169">
        <property type="entry name" value="DNA-binding protein SATB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO35908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000327101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13752" checksum="2B178A23BBC040F8" modified="2016-09-07" version="1">MSPKPTGGETIGHQQITTNGNGNGNGTAGQPPQTQTPSNTVARSRLMFDPLTELPVLEKWFEENPHPTWLQIDHYTEALNSCQYRQSYPPISTHNVKIWFKNRRAKCKRMQTGDLNLKMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7F0</accession>
    <name>A0A183H7F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3412</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002270">
        <property type="protein sequence ID" value="VDO36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7F0"/>
    <dbReference type="WBParaSite" id="OFLC_0000341101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000341101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000341101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000341101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15632" checksum="467225F045132054" modified="2016-09-07" version="1">MHDPRLSPGSPCMSPNSRQTNRYTILDKWACQAHNNNARRRVSSSQPNSMSFSLSCRNERKRDEIFRIDYMSNEERKKERDCLDGGGAVDNELSVCLSVCASLGHLRGRSVVLWQKPIDHCLLCVVGLFGSVYEVKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7J2</accession>
    <name>A0A183H7J2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="10">HMG-CoA synthase</shortName>
            <ecNumber evidence="3 10">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3454</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3 10"/>
    <dbReference type="EMBL" id="UZAJ01002309">
        <property type="protein sequence ID" value="VDO36550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7J2"/>
    <dbReference type="STRING" id="387005.A0A183H7J2"/>
    <dbReference type="WBParaSite" id="OFLC_0000345301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000345301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000345301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="12">
        <location>
            <begin position="183"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO36550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000345301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55283" checksum="16C5A2AA14D90908" modified="2016-09-07" version="1">MKTIREVWLADQVGIRGIELYIPKLYINQKDLEVYDNVEKGKYTIGLGQDEMSFCADHEDITSICLTVVSKLLRNYRLSAKDIGFLCVGTETLIDKSKSIKTSLMKLFEENSDIEGVDVKNACYGGTQALFHAIDWVYANWELENRYAIVVMADIAVYDVGPARCTGGVGAFAALVGPNAVLTFERGLRATYMVDVYDFYKPNQPVLSEYPVVEGQGSLQAYLIAVDETYKLYCQKAEKLKNEVVKISNFDAVFFHCPFTRLVQKGFGILAFIDFKRGLSDHLTDIERAKPTAFLLEPREINYMSRDFTKMSTQISSKLWAQKTEPFLLLNRRIGNTYTASLYLQLISFFHRQVSRYFFSHLSGSSVEEDLNGRRLLFFSYGSGAASAMFSARIFLLDKDTKDQFTQMKQSADAAVALLEQRLCINPKRYSEIMALREKLLSSAVPYRPEGVRSNFTNEFSLFPNTYYLMNIGDKYRRYYAQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7T3</accession>
    <name>A0A183H7T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3544</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002398">
        <property type="protein sequence ID" value="VDO36898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7T3"/>
    <dbReference type="STRING" id="387005.A0A183H7T3"/>
    <dbReference type="WBParaSite" id="OFLC_0000354401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000354401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000354401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000037">
        <property type="entry name" value="B-cell lymphoma/leukemia 11A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO36898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000354401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="43382" checksum="0CCF920BE72F28BC" modified="2016-09-07" version="1">MQPNIPNMLALMQEYYAQFSLNNAASYLLGAGSPSVAPRNNNNGSAFNAITKITSSPEEPSPVAPNSATQSLGLAGFARSDTTAQDQLSSPGMKQGHWNGLGAFGSKRQRSSNNGSETLSPATPSGAPLHSKLSRLDDENNEDTKSTMLNVVDGDDLAFAEPAARRDTNAKKDRCTFCCKVFTNRSNLIVHLRSHTGEKPYKCRLCSYACAQSSKLTRHMRTHGQQGKETYHCNICQMPFSVHSTLEKHMRKCVVANNQNRENNQQFSPAEAKTIDNPSKMAAAAASTLADATSLLAFSNVSLNGSQLPANITQSNKIVLNWLQAMNVNRNSTPVPTPTSGAGIGSGDGHCASTNGVILPTGAEDSKGTGDTTGKGEDEEMLVEECESFSDMQKTLLKKETAALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8X6</accession>
    <name>A0A183H8X6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3938</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01002810">
        <property type="protein sequence ID" value="VDO38300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8X6"/>
    <dbReference type="STRING" id="387005.A0A183H8X6"/>
    <dbReference type="WBParaSite" id="OFLC_0000393701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000393701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000393701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000007">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="211"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="327"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO38300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000393701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="49719" checksum="2EF3E663E4E490CD" modified="2016-09-07" version="1">MSSPFKVITVKTKPYEGQKPGTSGLRKREAVETFIMFKVPEFQQENYTQNFIQCTLDAGLGDKKKGATLVVGGDGRYYCPETVNIIIQMAAANGLRKLIVGQNGFLSTPAVSCLIRKREINDGSLINGGIILTASHNPGGPKADFGIKFNCENGGPAPEKLTEAIYALSKSISEYYICNDLHADFTKIGKTDYNIDGYDVFTVHVIDSVKDYVQLMEQIFDFSKIKELLSGQTMGQFNVLIDSLYGATGPYVNTILVEKLSVDPKFLCHTTPKPDFGGGHPDPNLTYAKQLVDTMEKGEHDFGAAFDGDGDRNMILGKNGFFVTPSDSLAVIAANMKCIPYFQRHGIKGYARSMPTAGAVDRVAKETGLPIYETPTGWKFFGNLMDAGKLSLCGEESFGTGSDHIREKDGIWAMLAWLQILQEKKQSVENVIKEHWSIYGRNVFTRYFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA10</accession>
    <name>A0A183HA10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectonucleotide pyrophosphatase/phosphodiesterase family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4322</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003231">
        <property type="protein sequence ID" value="VDO39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA10"/>
    <dbReference type="STRING" id="387005.A0A183HA10"/>
    <dbReference type="WBParaSite" id="OFLC_0000432101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000432101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000432101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000432101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31574" checksum="8EC27058DFFB2A0A" modified="2016-09-07" version="1">MQSRHTRHSEPITKVYEFKEDISINSVEKNGKLPKSTILAWGIVIPLLIIANIIFGGIYMIARAKFQKDKRMPPDYSDLSVCKRKFNAPPLLIISSDGFRDSYLDQNITPAIQRLINYGTHSKFMIPTFPSKTFPNHYSIATGLYPAWHGIVDNHFYDPQFKAFFKKSTNQSGWFLGEPIWKTAQKAGLKSGVFFWPGSEAMGKLPSLWMKYNSSVPFTYRVDTLIKWLKLPDDERPSLIQAYFEEPDLAGHMSGPNSDTVILSHMLLSGIKFIICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAE2</accession>
    <name>A0A183HAE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4454</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003390">
        <property type="protein sequence ID" value="VDO40063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAE2"/>
    <dbReference type="WBParaSite" id="OFLC_0000445301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000445301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000445301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000445301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13344" checksum="2C3262B693D91EB4" modified="2016-09-07" version="1">METVTRLRRVAYGFDCVVGYAGCRCSEVLGYCVAVFVVTAWSQVIRGLGMTKDSSLLAVLVWMGSGIYIFSVVILHFTLLEGLILFIAFGLFCLKVSGCLWRILLFVVSRYVFLKVVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBC8</accession>
    <name>A0A183HBC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003818">
        <property type="protein sequence ID" value="VDO41047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBC8"/>
    <dbReference type="STRING" id="387005.A0A183HBC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000478901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000478901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000478901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552458" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000478901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="7096" checksum="D69C42EE25FEC09F" modified="2016-09-07" version="1">MNSRIVCWNLAFLILVLAKRKLKEQEIIQRTLKDYDWRVRPRGNNLSWPGMQFLKLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBQ1</accession>
    <name>A0A183HBQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vigilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4912</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003974">
        <property type="protein sequence ID" value="VDO41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBQ1"/>
    <dbReference type="STRING" id="387005.A0A183HBQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000491201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000491201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000491201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="206"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="278"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000491201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37136" checksum="1F462889380354E5" modified="2016-09-07" version="1">MIPRVYYPFIRGPFNETIDELASKTGAKINIPPPTASSEVIVITGEKEGVHHAAAAVRQIYENMKAIVKPVTCQVTRAQHRYVVGPQRRGLAEILKATGVSVEVPPEEEDSDTITLRGDPTKLGEALAMVYAKASSVITAEITCDPWMHKFLIGPKGATLENLVPNKDKVQIGFEQDGLIYLEGAPEEVKKAQMSLGCEIKRLTEKMSSETIKVSPSLHRHVIGRGGALISKIKDETGVQISIPNEQTNSDEIKIEGNKEGVKKAIEEITEIVKRIENEKSRDILIEQRFHKQLIGAKGETVQKLREQFPSVIFSFPDPGKKSDIVNLRGDRVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCB8</accession>
    <name>A0A183HCB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PCP_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004249">
        <property type="protein sequence ID" value="VDO42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCB8"/>
    <dbReference type="STRING" id="387005.A0A183HCB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000512901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000512901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000512901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000512901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="6102" checksum="0ADCF0F9E0510A8D" modified="2016-09-07" version="1">MIRLMADDVVPRWTRDERRKWAEQKHQDMVNGLIPLPKGIGLSEILSKSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDA8</accession>
    <name>A0A183HDA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PFU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004716">
        <property type="protein sequence ID" value="VDO43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDA8"/>
    <dbReference type="STRING" id="387005.A0A183HDA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000546901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000546901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000546901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PFU" evidence="4">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000546901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37968" checksum="0737A70E3E1B3556" modified="2016-09-07" version="1">MANSGEGGFLEIWDVNDDGSLTHKQLIRTPAQSLWSLTFLRNSDIAVGADDGNIYIFSTVANRKANASIMGSFQCAVAKKIAEVEAVLSAQQNEIVKIKVALDDGEPHIELRYKKGSDPYDAAQTFLMENNLPASYLNEVAEYIIENIPEARQTTNKKMAQSQSTEKEWDYVLDVTTEDGRILKLPYNVGEDTNWAAQRFIEKHNLPIKFLEKVSTVLRLQVPGTIGNSSSSRFDNFNDPFTEGRYVPGAIKNQTPNEIGFVTDPFTGGNAYVSNSASIVPNMRLLIDKKRPRSEFVPLSNFFQFGIEQASAKAIIKLRELNETQSKYRLNEEQDLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDI4</accession>
    <name>A0A183HDI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5545</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004822">
        <property type="protein sequence ID" value="VDO43495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDI4"/>
    <dbReference type="STRING" id="387005.A0A183HDI4"/>
    <dbReference type="WBParaSite" id="OFLC_0000554501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000554501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000554501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14534">
        <property type="entry name" value="PTP-MTMR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000554501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58815" checksum="740C1834EFC28552" modified="2016-09-07" version="1">MIDPTTSGLHRHYLIDYDRLGLNHGSFRLTNVNRRYELTKSYPNIIVVPANTPDDNFTKIGKGFRHGRFPVITWKSDNGALLVRGAGFSAQTVVSRLRKQANFLGSSDNQNMGYNGSYMSLNSRDMALPNSVELQERYVSMFAALSPRMANGDGHSLMSESVESLLSLYSMITADGLSLNSGTPDLYRKSQTDIARHAANFVRNSGGRSGIKPANGDRFVGYVDNNIQPRHTNLGRGQTVKPLISLTRKALYVLGDRNQAKMLKLDKRCEFIPVNYPSAHNVKIAFKKFLRAACPSWPLYVDPSLTFLKQIDESLWLHMVSSLLHLACAIVDLIDVQLSTVVICIEDGWDATCQLTALSELLLDPYYRTFEGFRVLVEKEWLAFGHRFSHRHNHTAASQSSGIAPMFLLFLDAVHQTWEQYPSAFEFNDFYLRFLAYHSTSACFRTFLHDSEAERIKFDSLTLSAGEPRAASLWTYIDQKRLGSPLFDNFMYVAEMHTVLRPQSSVASITLWPFYCEDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEN5</accession>
    <name>A0A183HEN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deleted in lung and esophageal cancer protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005390">
        <property type="protein sequence ID" value="VDO44893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEN5"/>
    <dbReference type="STRING" id="387005.A0A183HEN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000594601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000594601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000594601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000594601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32646" checksum="23BC1A33E43E0FB2" modified="2016-09-07" version="1">MKITVSDGSKEGEQLPLYEFTADNIEVSPRKETVKMYKMSLPHSCCTTARQLMVNGLSLEMGSVHSSVYGTIDWDAQSLSYGTYDNSYMNSILDACVGWTTLKIEPREAHFRLEGSDQSEALLGEIATVPLSFICEESSPVESIRLDWCLDLKEELVGTLVFVNEENQFVANDTKVLKYNSPQIPPFKVQLNIRYCTQIVCSANLSVVVSIPLDDITAQKRFLISLRSRPPFDISSKILTINNDIVDNPLAEINFFIRTNITTVADVVISDISWKPGIEIETDKDENMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEZ7</accession>
    <name>A0A183HEZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005549">
        <property type="protein sequence ID" value="VDO45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000605801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000605801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000605801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000605801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32495" checksum="580E7397731798D0" modified="2016-09-07" version="1">MTVEYSVSSSDERIAILSSASDVRTCKSLSSPIFTNSTPINSENFNVCPITLSEKDSQKEHEKIAKQKDEIRITGGTERKWTTRIIRRVHSEEVISYGERIADDLINEYCDKLNTALRNRFDGMLAIQYIALDPQNLDRLITGKKPVLQILLDQKREHYVLVERTLIDDIVVVFDSLATSRKKARDALNHGLAEQIFNMFKHLSLTKEVKVRYEIAIEKQDDVWSCGLRTVAYITCRAFDRNPQCYIFNMEKVFKYFCNLLNVQNPNVEEFRHAFRRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF43</accession>
    <name>A0A183HF43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005619">
        <property type="protein sequence ID" value="VDO45425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF43"/>
    <dbReference type="WBParaSite" id="OFLC_0000610401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000610401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000610401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000610401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4573" checksum="55C7EB74D7A2487C" modified="2016-09-07" version="1">MKMVIQFVYFVMKNWVLNMIGLNISNWKSRNLSKILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFX5</accession>
    <name>A0A183HFX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6389</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006039">
        <property type="protein sequence ID" value="VDO46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFX5"/>
    <dbReference type="STRING" id="387005.A0A183HFX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000638601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000638601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000638601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000638601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9607" checksum="684206ECAF1431B7" modified="2016-09-07" version="1">MLLGNKCDMAERRVVSRERGEKIASDHGIRFLETSAKANIQIDKAFYDLAEAILDKMPVKDEGMKQPTIRPAEPQSNVTIGRLSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGN5</accession>
    <name>A0A183HGN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006441">
        <property type="protein sequence ID" value="VDO47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000664601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000664601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000664601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000664601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5662" checksum="8E4C7906C7B8D205" modified="2016-09-07" version="1">MEFKKENEISVVELSNCYANTSVPIMVIPYQLIFMRLNLKAHLVHRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHG3</accession>
    <name>A0A183HHG3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6926</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01006899">
        <property type="protein sequence ID" value="VDO48493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHG3"/>
    <dbReference type="STRING" id="387005.A0A183HHG3"/>
    <dbReference type="WBParaSite" id="OFLC_0000692401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000692401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000692401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF2">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO48493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000692401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21486" checksum="D61BBB4310C600EE" modified="2016-09-07" version="1">MAMMYSRFKQWSLFRSSSFSFLFSNITKIASTSNIAKIAKENLNVGTIGHVDHGKTTLTAAITKILSTKGKTKFIKFEEIDKAKEEQRRGITINVAHIGYESDARRYAHTDCPGHSDFIKNMICGAAQMDVAILVIAATDGVMAQTKEHLLLAKQVGVSSIIVFINKVDLVDNDVVTLVEIEARELLEYHGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI61</accession>
    <name>A0A183HI61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArgoN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007312">
        <property type="protein sequence ID" value="VDO49699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI61"/>
    <dbReference type="STRING" id="387005.A0A183HI61"/>
    <dbReference type="WBParaSite" id="OFLC_0000717201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000717201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000717201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000717201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8795" checksum="084958BBC267F21E" modified="2016-09-07" version="1">MELGRASVSGPPVRLAEKIAPGTRACESLDIITNVWGLIPRQNIPVYRYDFRVLEEYPPKKGSNEPAIKEVTKQTRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJJ3</accession>
    <name>A0A183HJJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008136">
        <property type="protein sequence ID" value="VDO52056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJJ3"/>
    <dbReference type="STRING" id="387005.A0A183HJJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000765401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000765401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000765401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000765401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11785" checksum="FEC7D5F541537A15" modified="2016-09-07" version="1">MPREVRDTTNTILRNDLDLVHVIYMHEKPQEPIHCNLAELLKPPSERESVKALRDNQKLGHYTRQMIYKRAEKEWKAIPKSYPIAEPEIIGRLKPHKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJR4</accession>
    <name>A0A183HJR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7729</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008253">
        <property type="protein sequence ID" value="VDO52328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJR4"/>
    <dbReference type="STRING" id="387005.A0A183HJR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000772501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000772501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000772501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO52328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000772501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16209" checksum="0CA4491A7C4B7D5D" modified="2016-09-07" version="1">MESVVVETNGKELLEQLRPLETPGENNSSEVPPEWMTFIWPYISALGERVRLMLNPDHPYNFEYSPEWKGLNKEMMASEAARRLTFQNWPHMDYRWALPYQMAEAGFYHQPNSAGDDRVLCFSCFVCLVCWEPSDEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL31</accession>
    <name>A0A183HL31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8192</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009068">
        <property type="protein sequence ID" value="VDO54475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL31"/>
    <dbReference type="STRING" id="387005.A0A183HL31"/>
    <dbReference type="WBParaSite" id="OFLC_0000819201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000819201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000819201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000819201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18907" checksum="2089743564853B02" modified="2016-09-07" version="1">MVGSVVKKVIPVGEKKSLKETYPDHETRILHQLERKLATTQLSCVKITPESRKKFQTGKTMKSKSLFLSGEGAIQESDERHALAEHLRSIAPFNRRWQVTETINEGTYGVVFAVRDVETGVHGVIKVAKSVGKDAGNQAAEWEGFVLEKIYKSVSFLLHLHKIKKFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLA4</accession>
    <name>A0A183HLA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8267</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009208">
        <property type="protein sequence ID" value="VDO54863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000826501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000826501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000826501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000826501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8258" checksum="7FC8D3BF8EEB69A8" modified="2016-09-07" version="1">MEEGICRVTHRSDRPTGRRVDWWINGRAQMAHLLRKFFPLRAVAVILSNRPNETISPTHPFIDRAQDDDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLB5</accession>
    <name>A0A183HLB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009226">
        <property type="protein sequence ID" value="VDO54919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLB5"/>
    <dbReference type="STRING" id="387005.A0A183HLB5"/>
    <dbReference type="WBParaSite" id="OFLC_0000827601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000827601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000827601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01776">
        <property type="entry name" value="RA_Rin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000827601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12571" checksum="A16C318A8DD47DBF" modified="2016-09-07" version="1">SVSPVLLSSSDAFVKVAVPDELDGSIRYHTFPGVPQMTAGKLCRVIAHQFGITNPEDHGLYLLVDGYETCLLANECPDLIRHQLRQAHKAHLFAYKRHEAKIAWPKFTVSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLM5</accession>
    <name>A0A183HLM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8389</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009440">
        <property type="protein sequence ID" value="VDO55433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLM5"/>
    <dbReference type="WBParaSite" id="OFLC_0000838601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000838601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000838601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000838601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3565" checksum="3B326E9A9A7CC23C" modified="2016-09-07" version="1">MLERWQIVSFSGKKVISLMNEYLMILSFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLP5</accession>
    <name>A0A183HLP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAP1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8405</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009469">
        <property type="protein sequence ID" value="VDO55518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLP5"/>
    <dbReference type="STRING" id="387005.A0A183HLP5"/>
    <dbReference type="WBParaSite" id="OFLC_0000840601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000840601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000840601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552572" evidence="2">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO55518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000840601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25392" checksum="1124946BBE92A906" modified="2016-09-07" version="1">FGVINLLILLEFISFLFDVSRLQSQLRKCYSRMELRQVQYDEEVNAFRRESEEAKLQLTKVKSRLSELEKECIAYREKAMAVDANRNSAVASSLEKISAQEREIATLRNDLERHMQLVKNLERMKKEYEFLELQNEALNAKLDSKEATIRDLEDNIHTMKMDTSRKIESGSVTPKADAFSFFDAEHMKFLSNSKETNARETVSFYYLITDLMEDCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLW7</accession>
    <name>A0A183HLW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8479</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009628">
        <property type="protein sequence ID" value="VDO55853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLW7"/>
    <dbReference type="WBParaSite" id="OFLC_0000847801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000847801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000847801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000847801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22947" checksum="E480FCB1AE0A9DD8" modified="2016-09-07" version="1">MKWIEKHNTEGEKKKDINKIVGDQTSESILKIWSQANPDAKNDQLFGKHRDAVMEVKGGRQFSQKELDASRAAIPKFQDPRETAAAKAQKASVISIFTRCNGLVENKQTETGNAKRNEDNVLDSNYMAWIGGQLTLQSESNPNDLQKSHDIISKSYFDRVMSEKEYVMGKAKKEKREKAKLRSKFELDGRERKIKETEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLY7</accession>
    <name>A0A183HLY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8498</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009658">
        <property type="protein sequence ID" value="VDO55965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLY7"/>
    <dbReference type="WBParaSite" id="OFLC_0000849801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000849801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000849801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000849801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13141" checksum="68273488C50CD7FB" modified="2016-09-07" version="1">MSKRNLQSSNSSPKSETVRLQEYSKNEGDFDAETCSPSISSFDENFNCDETYIITIDDPHVDAATSALSITDSNNSDKTQFAAKIPARSISRVMDEEMRQKIKTKVVCFFILFFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMC2</accession>
    <name>A0A183HMC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variable large protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8635</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009933">
        <property type="protein sequence ID" value="VDO56649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMC2"/>
    <dbReference type="STRING" id="387005.A0A183HMC2"/>
    <dbReference type="WBParaSite" id="OFLC_0000863301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000863301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000863301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000863301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="3897" checksum="1A0770A012016C94" modified="2016-09-07" version="1">MRQTVAVGVIKGVEKTEGGSGKVTKAAQKVGTAPAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMJ4</accession>
    <name>A0A183HMJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8706</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010065">
        <property type="protein sequence ID" value="VDO56982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMJ4"/>
    <dbReference type="STRING" id="387005.A0A183HMJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000870501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000870501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000870501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000870501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16149" checksum="4D93B6418C5A9FA3" modified="2016-09-07" version="1">MWFRCIISCRRLKCEHVAGSIFHPKIAVTQYHLQNDSSKISLQSSLILSENLENNTKGWILLGCFGVLTLTGGVSLLKHLLRIGHADARSNLKIEKRDDLPSYRMEEVRKHGKNAETIWVTYQGVCPFSLIYFNFHFNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNB8</accession>
    <name>A0A183HNB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8978</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010592">
        <property type="protein sequence ID" value="VDO58250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNB8"/>
    <dbReference type="STRING" id="387005.A0A183HNB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000897901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000897901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000897901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000897901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10803" checksum="3CB97EC23AE6558F" modified="2016-09-07" version="1">MVDAIVTDRIRCILFARVLKLKSLVEWTPQRTRGNPPQDIIVFVIGGGNYVEYQNIVDYGKSKGLTRITYGCTELVNPKQFVEQKSSKISELQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP16</accession>
    <name>A0A183HP16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9229</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011107">
        <property type="protein sequence ID" value="VDO59271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP16"/>
    <dbReference type="STRING" id="387005.A0A183HP16"/>
    <dbReference type="WBParaSite" id="OFLC_0000922701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000922701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000922701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000922701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17161" checksum="5C76DC75DCE03AE3" modified="2016-09-07" version="1">MLRSLQGDIEIDGFAPEPLNAEKLLKVDDPLEEASKFVQPLLQLNSEQFGSYILGFEVYYRKKKVLLMLQCLNKARKLRPNSPDLHVAASKYLHYYEKAQLEGTVKELAAELTSTLFRDTKSASEFNTAFKSANINSFPHRLAGIHCYFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP49</accession>
    <name>A0A183HP49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011176">
        <property type="protein sequence ID" value="VDO59418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP49"/>
    <dbReference type="STRING" id="387005.A0A183HP49"/>
    <dbReference type="WBParaSite" id="OFLC_0000926001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000926001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000926001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000926001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9689" checksum="379DF24F01956F7A" modified="2016-09-07" version="1">MDLLQTAVPTHLVHTARQQFAKSPPTIYTEHYNQTSVVYCRLVGLEDILSCCSAQDSALLLNEFNTRIDQIIKVNIIFDLSFFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPA4</accession>
    <name>A0A183HPA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011297">
        <property type="protein sequence ID" value="VDO59681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000931501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000931501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000931501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000931501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3841" checksum="84DB5902B93BA0F0" modified="2016-09-07" version="1">MRMLPLEDRLIYLDTPELTRNCSDDQCPEYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPG4</accession>
    <name>A0A183HPG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9376</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011425">
        <property type="protein sequence ID" value="VDO60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPG4"/>
    <dbReference type="STRING" id="387005.A0A183HPG4"/>
    <dbReference type="WBParaSite" id="OFLC_0000937501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000937501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000937501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000937501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24064" checksum="A54E5B6F617ECBBF" modified="2016-09-07" version="1">MKDEGNTAEVIRLTVENAIHRKAFEIAQCANNKQESLLRQLLAVTFQAAKEGYSLDIYAQIRSPLILALLALNFCAKGTTVAVIQDIFDVSPVKRCEELFVIVEDNLPQWKMSIFYEPCKNMILRMCNDLLKRLSRTVDTSFCGRILVLLARALPLCEKSGLNLVSHFNLGNVTKYDLADSCLAADVNLTEDNDIMEVGEISERYLFYFQISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRM1</accession>
    <name>A0A183HRM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10137</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013220">
        <property type="protein sequence ID" value="VDO66147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRM1"/>
    <dbReference type="STRING" id="387005.A0A183HRM1"/>
    <dbReference type="WBParaSite" id="OFLC_0001013201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001013201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001013201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF5">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0868">Chloride</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO66147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001013201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13614" checksum="FE64A1F9BC2E2722" modified="2016-09-07" version="1">MIHNVFCITRSTTYGELRELLLATPHLRSYPLVTDSKSKILLGSVARKYLNYLLYEKLGSDSMIVRRRTNTTSEILNHLRRSSRLSTTNLLTDRNISGNTLLANSPLHDDRIGGNYKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS39</accession>
    <name>A0A183HS39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013572">
        <property type="protein sequence ID" value="VDO67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS39"/>
    <dbReference type="STRING" id="387005.A0A183HS39"/>
    <dbReference type="WBParaSite" id="OFLC_0001030001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001030001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001030001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001030001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10256" checksum="2390477B57A7FD5F" modified="2016-09-07" version="1">MDCGSSSSSGCSSATANNDHCGESLAITSSSSAASSLSSLCSGNIQTSLNSVQERTVYGTNRAATSLLSSANHQNIKHNKNSSVIEAGIRNEAVVFGKAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSE6</accession>
    <name>A0A183HSE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013833">
        <property type="protein sequence ID" value="VDO68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSE6"/>
    <dbReference type="STRING" id="387005.A0A183HSE6"/>
    <dbReference type="WBParaSite" id="OFLC_0001040701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001040701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001040701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001040701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8684" checksum="36EF7257D3C881D6" modified="2016-09-07" version="1">MQFCLELSEQKRVPLCLSFMVDILLERIEKKMEVKDSAAQAIQILQELKELDPIRKNYWDYNEKLVNNLIEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTA7</accession>
    <name>A0A183HTA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014599">
        <property type="protein sequence ID" value="VDO70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTA7"/>
    <dbReference type="STRING" id="387005.A0A183HTA7"/>
    <dbReference type="WBParaSite" id="OFLC_0001071901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001071901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001071901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001071901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11693" checksum="2210AC81F808395D" modified="2016-09-07" version="1">TKKVEKNEKNEARIRESEENAWKCLIKLTIVICLLSEMDELHTTAPTTTADTRQPFHGWDGWKDWTNRNIFTSSVDETTFIHGYQNQETTDTFANDSVQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTX8</accession>
    <name>A0A183HTX8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lateral signaling target protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS10939</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of epidermal growth factor receptor (EGFR) signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lst-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015187">
        <property type="protein sequence ID" value="VDO72550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTX8"/>
    <dbReference type="STRING" id="387005.A0A183HTX8"/>
    <dbReference type="WBParaSite" id="OFLC_0001094001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001094001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001094001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO72550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001094001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13218" checksum="C76AFDC2A6C9B9C3" modified="2016-09-07" version="1">MGVEVQEALPLPSLIGVRWVPDSDCEQCTACGAQFTLVRRRHHCRNCGRIFCSRCSANSLPLPELGYDRKVRVCNLCFLYKINPFSPCTSQSHSSRNHSSSAFNNAVTPAASGIVFNLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUE9</accession>
    <name>A0A183HUE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11111</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015627">
        <property type="protein sequence ID" value="VDO73945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUE9"/>
    <dbReference type="WBParaSite" id="OFLC_0001111101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001111101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001111101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001111101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16895" checksum="1D273D1C20C676A7" modified="2016-09-07" version="1">MSSGAFYPSPSPALTYPSPIIQFQPATSESEQQHSANTGKISTDTQATQHFSACLYICQDNCMQQCLEQNRSTKHCSISCSSVCHDNCAKQRQQQQQLMQSQELPQLIHHQPQQISRIQHSPPFTQIRQVQEIQNSKISHEQYYQSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUH9</accession>
    <name>A0A183HUH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015697">
        <property type="protein sequence ID" value="VDO74178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUH9"/>
    <dbReference type="STRING" id="387005.A0A183HUH9"/>
    <dbReference type="WBParaSite" id="OFLC_0001114101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001114101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001114101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001114101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8079" checksum="3E1ADB84CD882646" modified="2016-09-07" version="1">MERDSRPSRRRALTLRKGPENREMLIQMKAFCTTTVATGVQANITHLFFLSFFLDQNSILMAPCVSVKNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV83</accession>
    <name>A0A183HV83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016407">
        <property type="protein sequence ID" value="VDO76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV83"/>
    <dbReference type="WBParaSite" id="OFLC_0001139501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001139501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001139501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001139501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7959" checksum="6764B57093022DCB" modified="2016-09-07" version="1">MSALIDRGLRFAGISTRSNFLAPDNHFLPHLQPVSSPVRQQQPFQPVVQQQFPPFAQQQFPTVARQQFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVC8</accession>
    <name>A0A183HVC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11441</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016517">
        <property type="protein sequence ID" value="VDO76478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVC8"/>
    <dbReference type="STRING" id="387005.A0A183HVC8"/>
    <dbReference type="WBParaSite" id="OFLC_0001144001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001144001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001144001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001144001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12093" checksum="BF30207CB067F662" modified="2016-09-07" version="1">MISEDQQINFSSNDQFPKKITPPSLLYPRKLPPITPTSNESAPSTRLPCIPTLNRPPTQTRTVPFSHILDTVLNSPSSNKSETDEDIVEEIIPDDLLQSDNNSDASISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW96</accession>
    <name>A0A183HW96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disintegrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11759</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017435">
        <property type="protein sequence ID" value="VDO78992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW96"/>
    <dbReference type="STRING" id="387005.A0A183HW96"/>
    <dbReference type="WBParaSite" id="OFLC_0001175801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001175801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001175801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF248">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN UNC-71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disintegrin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001175801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6638" checksum="F98F7592353BD46C" modified="2016-09-07" version="1">MHSILQSGYLQCLLNKPLQASTLQQCGNGIIDGEEECDCGLRENCLDPCCDPLTCTLRAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWU1</accession>
    <name>A0A183HWU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11956</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017926">
        <property type="protein sequence ID" value="VDO80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWU1"/>
    <dbReference type="STRING" id="387005.A0A183HWU1"/>
    <dbReference type="WBParaSite" id="OFLC_0001195301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001195301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001195301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001195301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8557" checksum="2350CDE1901527DF" modified="2016-09-07" version="1">MSLVSSLSKKVNDLEEERMNSGEEKARLRADNAVLIERVHILEEQLQAAEQRFHHALIISLIIQQLLIIYSKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY43</accession>
    <name>A0A183HY43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039837">
        <property type="protein sequence ID" value="VDP11251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY43"/>
    <dbReference type="WBParaSite" id="OFLC_0001240601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001240601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001240601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001240601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9856" checksum="0BDA28D861FDB841" modified="2016-09-07" version="1">MADNQSHGCRKAMERNEKKTFVFGSSTPRDLSYMYSVPASLRTYDSKIKPIKRTKDETLSHYMRQARSITRNQSGKWSFVFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ1</accession>
    <name>A0A183HYQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12613</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039883">
        <property type="protein sequence ID" value="VDP11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ1"/>
    <dbReference type="STRING" id="387005.A0A183HYQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001261401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF37">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="117"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50497" checksum="314217BD4AA0A43E" modified="2016-09-07" version="1">MSGSVVGRERNICLGLVDQYVQTIATETNPTYCMANFDRSLCWKKTAVGEIAQRKCPFSYCLNVEGCEGIKNNYTVQRMCNENGSWAEPIYAQCIDVLKYHSHCIVGFCKTCPDLLREMVINVSLTLSIISVILLVTTLILFNTLNSIQCRRLSIHKNLASSFVFRFAVLALWTIAQTSNFFQDCSYYNSMPLYEYEWICKLLLWLVIYFQVASVMWMFIEGGYLYSRFTIFAMRSIDCPNYAFLFCGWGMPFVVVISWTIIHQKRSSQNQNSFCWLPYAKGAHLWVLSGTMGLALILNLLFLLGIVIILVQKLRAENTAESKKIWRTVKSTLLLVPLLGVSNIPLFYEPSQPSSVYMLGSAILQHSQGIFIAVLYCFLNGEVQNALKRQLPKLKMHILSEEPRFEIERSYTPDKLNELGSKFGMPMGELNNAGGSKRPHNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ5</accession>
    <name>A0A183HYQ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM3</name>
        <name evidence="12" type="ORF">OFLC_LOCUS12617</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039884">
        <property type="protein sequence ID" value="VDP11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ5"/>
    <dbReference type="STRING" id="387005.A0A183HYQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001261801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12027" checksum="2BB0FAA141496C2A" modified="2016-09-07" version="1">MTTEQGQTNVLSTGVEEPLDLIRLSLDERIYVKMRNDREVRGRLHAFDQHLNMILSQVEETVTTIELDEENFEEMHKQTKRQIPMLFVRGDAIILVAPPLRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ29</accession>
    <name>A0A183HZ29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12741</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039919">
        <property type="protein sequence ID" value="VDP12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ29"/>
    <dbReference type="STRING" id="387005.A0A183HZ29"/>
    <dbReference type="WBParaSite" id="OFLC_0001274201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001274201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001274201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001274201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="505" mass="55280" checksum="9BFD9EA2BBA8B97E" modified="2016-09-07" version="1">MENRKSEQIPGQLPPFSGRHISIHLSSHLVTPLHASQIRIKADVFHDSGRGITVTSIAHFDVDIILLCWSRLRQAYIEKFVVVIRLKYDTVAVSLEYGTADDCVVSFGRITTMYGHQSIPRSVSAGQLNAMMSHPGMVITSQQMINTPQGVMVSQAGYPQGMINTGQPPPQMMPSQAHMGQQMMNTHMSVVQSLNQPGHMNVQHQQMQQMQQVQMTPQQAYIQQQGMSHPNFVNGQARSPAVGPGPQGISQQGTPGRPSSTSGPPSNNPQTPLNAISTLNPSSQQLSTPATPQQAPSSVQSTTTQDNISVPTIVPPDPVSLARNLLLRDLRYSLQDWSKTAAEMIRPSTLRQQQDGSSAALHNPMSVNPQSVNPQSVNPQSVNPLSANPSSVKSLDEPKSVENLEKKILSPSEAYINSFDYFLGTCDQIENDIMVVQEAQKQSVKFDKMFAGELKIVGEMANVNYSQYAQGYVESTARVRNAITRTLKNLNAAMERMNAAKIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZL8</accession>
    <name>A0A183HZL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MRP-L46 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039981">
        <property type="protein sequence ID" value="VDP12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZL8"/>
    <dbReference type="STRING" id="387005.A0A183HZL8"/>
    <dbReference type="WBParaSite" id="OFLC_0001293101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001293101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001293101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="1">
        <location>
            <begin position="88"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001293101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="23040" checksum="C1092EED39FBDA04" modified="2016-09-07" version="1">MSNYHYNPFHHQRLRHFDKCGFYPYETLKYQWLLLVKCNVVSLWSGVERVVRNDVTLELVIIMGHRILHQVLRFHSSMAVSSKCSHVWDIFASVALIRPPIIAPPMLDIEKRYHDLMLQKELENSLRCDFELRQLRDERLLKERERLKMDGERANLQEEIGILASVDEENWRKEADRIRKELGIGDLTKVMHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZM6</accession>
    <name>A0A183HZM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS12938</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039983">
        <property type="protein sequence ID" value="VDP12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZM6"/>
    <dbReference type="WBParaSite" id="OFLC_0001293901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001293901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001293901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="12">
        <location>
            <begin position="396"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="11">
        <location>
            <begin position="1556"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="9">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001293901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1658" mass="188144" checksum="E62DB6E34858EA4A" modified="2016-09-07" version="1">MCAFVAAHAGAGTHPYKTEDICLKAVCKSKGDIVEAIKELENDFRTNCGFGSNLTFNGHVECEAAFISSEDHVFGAVGVVSRLRNPIEIAAMVAKEQLCGDKKFVLPTVLVGLGAEDWAKKRGIELCDPASLISKRSQQQWREAREIVRNWENETMDTVGAVSYENGCCNAACSSGGIILKAEGRLGHTIQVGGAIWADQRDSKSIAIALSGCGEYIAQTLNCEEDVILDKIKHVFNTAFLHSPYLQNRNERHILAGGLILFVDRENGCAELISFHNTKELTFAFFGNETGMKYRSRSVSNDFIAHSFSLRDHINLWGMHNPVKKFVIPSRDDDLLEESDDFCTIKFRHDIDAGRWSRIIDRFDYLFFTIKPFSEGEPWRLRSQLVALLNAGLKLTLDSIEELLPMLTSEAEAELAQDLSAEREMHARAFLIYIYLLCRLAVLFEKESSNRQSEASSTKKGRKTMSDKADDQYMIQWACDRGKTLKLLRRAFSMNSIDAQGRRRNTAIRFLWQPSIVPPELLKISKDLAFKFLENPELSKVSGREWLQAIFGYLKIICIDYNETAKIGAKLVNLMKRLDYLSLPSLTQSPFVDAIESVSYYDDMDILFQSMLSALSRLSKNDFARNDVSTRPFALFIVSLAEKKPYLLNKHIVNIASFLSDDPATLRCAVLTAFVEIVIVVYKGNLPEGNFRRSRDRLLLHLQDHTVDVNAVVRSRALQLWTRLARASQIPIVFISGGLIRDAGGRLIDKSVSVRRSAATFLSAILEYNPFGASLNADDLADAISHLEAERSELKNTNPEKEGIRKAYVEWASMKENVIHWITKAVKQRLSKRNAEASEEESVDNAIDQNGNENAAGDTENIYAVVSETDGISTTAIDECIIDDDVTLEELITKIVHALENRETCRAAIEVLVRAALDGRFPTVNKLQIKLLCYKFIEKLQVPLFHTDFRNGSADEIIRECYESLQVYYFDEHKKMQLADDKEMLELEDRIGDYQKTMEELDNKIKLHENALMFSLEIENCMKLALRSVMYGQANELTEIIHFIVEANKFAIRGSEKSVRELFKVIWRRDNAVKEIIVNAARDLFISANKDRDVSARKSAENLMKIFLGIGEEERVSVEEVLCLMARENRWDIDLLDVLSAVVFETQGASRIAALRLFSIVCRANKEFMRERLNFFIELTQREGFFDNDDGALAAEFFNAIAMLGSTPNMKDVGTLCEPPFRLPETHRILQCVHAVLVQNVANTSYNWLNMMQKAVNTIFYVAARPSLCCRLIASGLMHEAKRSLAYFFLKKREVKQIETINFENPPNSADVDEFEDLLAMRKERLRDCSETEDEELLESQNVDLVDDEKLSKMKKDALELLEKDKEQFFLVWETVAERVCAFAGQIALKTLVHTDVSFVAEMKRKNEILHIIRTTLNDIDLNKLEKANCVEEFSTSRTLSTLEAESIERHGFFEVNEQEEGDRLGLTGISEEERILERAQRICESAVSRKGSLLHRLSKFLVAIVKSKKNTCSEKLRSTAILALSKFMLLSMKTCIRLMPLFLEYFKNSPSSECRSNLMIAIGDLCFRFPNVIEKYSEHLYHGINDKDDYVRQTSIIVLSYLMLNDMVKVRGTVADLAQCINDENVNVGQLAKFFFSELAKKITVGNGFMSFYFICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I072</accession>
    <name>A0A183I072_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heme transporter hrg-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13134</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRG family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040058">
        <property type="protein sequence ID" value="VDP12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I072"/>
    <dbReference type="WBParaSite" id="OFLC_0001313501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001313501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001313501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026218">
        <property type="entry name" value="HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525:SF1">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16954">
        <property type="entry name" value="HRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02095">
        <property type="entry name" value="TRNSPORTRHRG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001313501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17291" checksum="782A00F80442A070" modified="2016-09-07" version="1">MALTCKMKFRLLCPIIGIISGIMAGLCFAIIYQNWSATTMAFISSLAAANLLFIHGKHIKGTMPVLSEVKITLILAINSILSALCFVGCLACIMLAGILHQNLTHKSLMNENLWITAVWFWMTFKWFMLSTYFFHEYTSQTMKGNFELFKGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0N0</accession>
    <name>A0A183I0N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13292</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040127">
        <property type="protein sequence ID" value="VDP13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0N0"/>
    <dbReference type="STRING" id="387005.A0A183I0N0"/>
    <dbReference type="WBParaSite" id="OFLC_0001329301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001329301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001329301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000026">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="387"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001329301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="830" mass="93116" checksum="F282853CCBBD59D8" modified="2016-09-07" version="1">MALADLYAARHTVLIAQRADDLQRISRKCREIGALAHGEICRVLNELHTAMRTYQLCFLESSTIESKFRQVEGNKARYEENNPTKLGVTRKHRCLAKLYNKRLEKYNTVKLKCLKARNEYLLCVQAANAALHKYFADDLSDLIDCMDLGMDQWLKGFINCTVSARKDICQKEMDALAELCGFKESLDLKADKQRGQLGDTVSTVSTTDVVAEELQQRHLQIERRLANVRIESEEIWKTLESTEKAVAERFMEAMTSSIAAAEVSNDASREDCNDANIYNFKNRINANELYDFYLGKFSHYMLNSNLIERLEARANGIASALNGYSNKNFDDSTSSAVVPSPNSFYRMFSNEDGDDSEIFSSARTRTKKRIGSGLLSDSIRRPKLFGGSLDEYVEATGETIPLIITSTIRVLSQFALHHQGIFRISGSQIEINIFREAFEKGEDPLRHVIDATDVNSIAGVLKLYLRELRESLFPIFLFDQLTECAKCSNADEFVKQVAPLIQKLSQPTQLVLRYLFAFLNHLSEFSDENMMDPYNLAICFGPTLLPIPEGKDQVFYHNFVNELVKNLIVYHEQIFPAILPGPRYEKYLVESEQALFIDEQESAISGDEETITTPIFDFSNEKSLTELKISAITPSCGAADIAVEMLSAASNITACALYNLPQSTVASNDQNPVVSNLSDDSMLATELISGPNNDVVKHFESGNNTAVIAAQNLSSMNNNEIPSNQERKQLQIWSRRGCGVSSLREQLHHSRVQQQVFTSDKSPSSSSLDALIFDNRFDGVIFGNKVSSIGNESLNRKTLSPSLSHENASISFSRFPNIPPANRHKKNANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1M7</accession>
    <name>A0A183I1M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13639</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040309">
        <property type="protein sequence ID" value="VDP14273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1M7"/>
    <dbReference type="WBParaSite" id="OFLC_0001364001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001364001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001364001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001364001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8969" checksum="3A31CF0F9549D1D2" modified="2016-09-07" version="1">MRNTKAKVARHNSKNDDKNVTQKRFNSQKNDKDRRSYSDSSEFQGFRLDSSKRSNSRNNSTAQLNSILPHQRQRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1V7</accession>
    <name>A0A183I1V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040355">
        <property type="protein sequence ID" value="VDP14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1V7"/>
    <dbReference type="STRING" id="387005.A0A183I1V7"/>
    <dbReference type="WBParaSite" id="OFLC_0001372001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001372001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001372001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001372001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26295" checksum="09A92D6597FACD06" modified="2016-09-07" version="1">MRPKITHVIFDLDGVLIDSERINFQIYQKLWSKYGKTFTPELMLRITGTPVASSASFLIQHFDMERQLSVQEYRKHYNALADEFLPKCPIIPGVMRLVRHLAKHKIHMAVCTSSSKIEFNVKTAMHLELFSLIPLIVLAGDDPEIKRGKPAPDPFLVTMNRFKEKAENAVNVLVFEDSANGVRSAIAAGMQVVMIPDMSYMKPPVEVIDKIGCILKSFEEFKPESMGLPPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2K5</accession>
    <name>A0A183I2K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CUB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13967</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040505">
        <property type="protein sequence ID" value="VDP15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2K5"/>
    <dbReference type="STRING" id="387005.A0A183I2K5"/>
    <dbReference type="WBParaSite" id="OFLC_0001396801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001396801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001396801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="306"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="438"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="559"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="683"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="754"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001396801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="888" mass="99987" checksum="5FD95B0204FCCC51" modified="2016-09-07" version="1">MYHLECNPSSSEQISRTCATRELRSTGSVLSVHLKGLNNMHLEHIHFSYSTQIESCGGTIHSIAGVIYYPFMENDFECECKLKLPFSEYCAESYLEVRENNNSGKIMTRACSFEDVAPTVTSRAFWIRLRYSGSEDDSGDIEPLKPELMIKFKKVFGGVTNNAVVSSPAAEDWQSIDFAPLEWILIGEEDNWLRISIKSIEIPDERDESNIDIEQRDTLKGLVFNEGICMLNGKNDGCGRVEFVHAGYTPPNDFFIKSHLATVLFNAPPGSSFRFHWENIPITVANASLPKANQTIIEDSMQEFACGGTLTATFDSQYLTNPGAKSADGQFTTVIPHASTVGIWRSISMYRLSRWHGGYANGLKCRWTIIRPMFAGLRLKIISMDLEEHVDCRFDYVAISSDVDGVNYENGQLIGNIVKFCKHKDVGTEELFSSEDAVTIFFMTDRNRGGRGFSPNYPNEYSNNLSCSWSVMLESNRPILAKFLIMDIEESALCTKDNIIVHSNPIYLDGATSDDKLCGNRTGWNKTFPNGRVFISFTTDSNTTRKGFALQLMEQIYDCSSDQLVLTEDDSPKVLSSPGFPKMSPNSLDCIWTISASGGHRIKFTVDPISFNLEDTTMVDACTSNYLEIRDGPSKLSALIGRYCGKEPPSTIFSTGSYLNIHYQTDSFAHFAGWNATYEIASCGGSVVIPKNGNRVITSPNYPEPYPSQATCEWTVVAPRGHYVNATFDHLWILFTENCTEDSIALRERDSTECGGDIIDDSGYITTPGYPNQLQAHIICEWTFRAGIGFRYVFDFAFVKHETTYNEVNCYPDIYITNGLNKMMDYYGFVDRNFCSNETRFVSTADLVTIRYNDRAAAYEKQNMRERGIPPEKIYAPFRISYFKVLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Y0</accession>
    <name>A0A183I2Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P4Ha_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14092</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040592">
        <property type="protein sequence ID" value="VDP15468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Y0"/>
    <dbReference type="STRING" id="387005.A0A183I2Y0"/>
    <dbReference type="WBParaSite" id="OFLC_0001410001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001410001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001410001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase N-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase peptide-substrate-binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001410001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="53741" checksum="46BA80189509BBD1" modified="2016-09-07" version="1">MYTSGSSSSRQSESSDFVKTGEGRKIIHYLPLVKFPLHKGKVDVLNTGKMISYTVMNIFLSIATVSAEFYTSLIMLKTVIGAEKDIPIMTNSYMKKELERLDYLKKFAREIQERNDKVIRDGEKTTRNPINALLLIKRMTADWNKLVKIMQSNSADDVIRNVTCQKDIKHTYYPTQEDLSGAVIGLLRLQDTYQMGTRDIADGRILSSQMRRITLTAGDCFEIGLAAYRKYDYYHTILWMQEARERTKTEAVPTANLEDILDYLAFSLYKQGNLKRALLLTDELYHINPDHPRAKDNVKNYEDLLEDDGVERIDMRRNIPRINNVRIENEFDEGVKLTYEALCRQEVLVDTKAQSQFYCYYKMDRPYLRLAPFKVEIVRQNPLIALFHDIMSDEEAGIIQMLGFNGQAKINLFFSWRNFLFHNEFIVSASLKSTEHEIVKRIDRRLEFATNLEMGTAEDLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I310</accession>
    <name>A0A183I310_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TRANSKETOLASE_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14122</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040612">
        <property type="protein sequence ID" value="VDP15564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I310"/>
    <dbReference type="STRING" id="387005.A0A183I310"/>
    <dbReference type="WBParaSite" id="OFLC_0001413001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001413001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001413001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP15564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001413001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="42255" checksum="CA347B354201902C" modified="2016-09-07" version="1">MGKIDIQQLNDMANHLRIDSIKMTCAAKSGHPTSSCSAAEIVATLFFSEMKIDKAFPKNPSADRFVLSKGHACPVLYAAWHQAGHISTADMMNIRKISCDLEGHPTPRLDFIDVATGSLGQGLSCAAGMAYAGKYIDKASYRVYCLLGDGECAEGSVWEAAAFASYYKLDNLVTIVDMNRLGQTQQTMLGHDAEALAKRFESFGCHTIIVDGSNVVELLNAYDIARQTKDRPTAIVAKTLKGKGIVGIEDENNWHGKPVPENTIEAIEQRLMNKEDMTGTLQTKLPVNDAPCVQLPFGCIKMAPPEYKIGDKVATRQAYGTALAKLGDACPRIIGLDGDTKNSTFSENLLKKHPEQFVECFIAEQNLVGVAVGLQCRDRAIPFASALFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3X2</accession>
    <name>A0A183I3X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14434</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040854">
        <property type="protein sequence ID" value="VDP17032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3X2"/>
    <dbReference type="WBParaSite" id="OFLC_0001444201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001444201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001444201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001444201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="8113" checksum="7A683F473CCCF44D" modified="2016-09-07" version="1">MGEERNSRKERKSEGGNLQETDVLREKRRKTDELREKRRKTDELREKRRKTDELRENESITVNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I571</accession>
    <name>A0A183I571_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14883</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041319">
        <property type="protein sequence ID" value="VDP19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I571"/>
    <dbReference type="STRING" id="387005.A0A183I571"/>
    <dbReference type="WBParaSite" id="OFLC_0001489401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001489401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001489401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001489401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20578" checksum="06A4C999623085DF" modified="2016-09-07" version="1">MFFSSNMEKLNGLNSKVNGWIKNMEDELTTINQETAELKQKKAVLIENLKCIQRQVSKRSHDFTLKREDWEDERQKLSLEVDVAQNEHDSLHALRNGKLSVHEQLAETRKILQSRQIECDEAKKKIVNEVAVKFSTLVEQWEHLKNCYDQLRNFEKLLREALNNLTDDKKQLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5B0</accession>
    <name>A0A183I5B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14923</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041361">
        <property type="protein sequence ID" value="VDP19605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5B0"/>
    <dbReference type="STRING" id="387005.A0A183I5B0"/>
    <dbReference type="WBParaSite" id="OFLC_0001493301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001493301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001493301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="98"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001493301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39704" checksum="3E714E4845E75AD5" modified="2016-09-07" version="1">MLLEKHSRILTIAMEALIQDFEPRDAIPYMCSEEIFNDDQQEIILGMIFTMKHLANLLSKDYIPEDRPLLAPDALENRLFLEGNVPRLPFYHVLRMNLLEKLKNLLIDLSSRDRFWLVIHGFPGCGKSFLAASVLHAHPILLSRYYEYVIWVEDGRTTASHLSEVFSNFVFLVTDALVLTGKEIPAQFLPLAKTALREKPNTLVILNDIYLQESVRWFDQLNCRILATSRNLEIFQVTSTNPVHFAIDPPGFSLTEMEKMFQQPHFSTAMDSFSYNEYLFHIYEKTMGLPALLGILRQQACDNHNNFYNLSGLLNYTIATISNYTYYKHKNMIDAIMESYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5W9</accession>
    <name>A0A183I5W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15131</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041660">
        <property type="protein sequence ID" value="VDP20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5W9"/>
    <dbReference type="STRING" id="387005.A0A183I5W9"/>
    <dbReference type="WBParaSite" id="OFLC_0001514201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001514201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001514201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001514201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50699" checksum="8BA8784B86E6CDA0" modified="2016-09-07" version="1">MMISLARLLLCGSSSNIGQTSYILPVIINHLDHLPVFSLSMANLFSYGSPEERFSHCVQSAIRASSSGTPCLLLIPSIDRWYSSVPPSVWNLLLSAISSFTGFTSILLLSTAECSYSDLHADVGSCYIILLSKSSEVKFKIQSIFRSQDSIEITPPPVDRLEAYFRHVIVESACTPPITFNADDYPALPKADVVQPSNRLTSDEIKELKKLYDQYHLEVILHYEETIARLIRDRRFTAFVQPVDPVDVPDYYTHIKNPMDLGTMFSKTSSYKTPEEFLNDFRLIHRNAVEYNPLTDYEGRQIRIMAKVLLDMGQRAVLELDSKFLKRLEDVKKLLKENGIKVDGDSDEGDRGEQRNGYVANDCEIHTKNDQLTMDEPEELKKTSIKRRGLHTYKLSRKRRCIKKSLKKCRTSHPILNSQTEGIDVEDSVLSEGDQPITDDDKDFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6A1</accession>
    <name>A0A183I6A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15263</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041844">
        <property type="protein sequence ID" value="VDP21063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6A1"/>
    <dbReference type="WBParaSite" id="OFLC_0001527401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001527401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001527401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001527401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="6257" checksum="C570EDF80864A47E" modified="2016-09-07" version="1">MARVGSMKQKQYDEVTCHLNVIFSVIREISGFRGFTGVSVFRVFLFMFRMEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6F4</accession>
    <name>A0A183I6F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041943">
        <property type="protein sequence ID" value="VDP21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6F4"/>
    <dbReference type="WBParaSite" id="OFLC_0001532701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001532701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001532701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001532701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8835" checksum="2B185C1F9225045A" modified="2016-09-07" version="1">MRYIFDAARISFQNDVCAFCGGDLDMERQMVTHNGCIVNRRSETLRQVDQWKGKKGHPRSTTVSQSLILTHNGPVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6J6</accession>
    <name>A0A183I6J6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15359</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042010">
        <property type="protein sequence ID" value="VDP21500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6J6"/>
    <dbReference type="STRING" id="387005.A0A183I6J6"/>
    <dbReference type="WBParaSite" id="OFLC_0001536901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001536901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001536901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP21500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001536901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21151" checksum="053D66B60A7B3070" modified="2016-09-07" version="1">MTAIYFCLSDPTKPVQLQAVTPIAERFHSAAWPQLTQRNPDRPRVKNYYRNAQVGFWNGLVPQLHASGKEGVPVPEEHHFLPNHFKRDSFFGTVRPYASYANEPFPPPPLPPTPLPKFIEKLTTLSSRETNSDRPSTTPVPLVKASQNSTMLSITVAVGCGLLFLNICIGLGLYRQVRSQVPKILLSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Z9</accession>
    <name>A0A183I6Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042277">
        <property type="protein sequence ID" value="VDP22280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Z9"/>
    <dbReference type="STRING" id="387005.A0A183I6Z9"/>
    <dbReference type="WBParaSite" id="OFLC_0001552201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001552201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001552201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF6">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001552201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27848" checksum="A2C64F3A5F109F24" modified="2016-09-07" version="1">MLNNCPPGYQCQQSSTMGHYLCCTSGHLNTRYAGYCPMGQIPYVRYANEEPQTCHMTLHPCPTVAQYMCIYSAEKLNSYCCAPIDTTYMGQSGISMQQYRQQIPTVEDGSGCPMGSQSLMDQWNRIQGCNPGMCPQMYSCHYSVQYNRYQCCSNMPGSFKMASAIAADIAENSECEPGSTRIKVLYLGQKGCTENEQCSVRVAEARCKRNYCVCPSNKLIHQSKCVTHCPEGLFHVSLLFSFIYRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I758</accession>
    <name>A0A183I758_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS15570</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042382">
        <property type="protein sequence ID" value="VDP22638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I758"/>
    <dbReference type="STRING" id="387005.A0A183I758"/>
    <dbReference type="WBParaSite" id="OFLC_0001558301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001558301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001558301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP22638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001558301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35378" checksum="BDB14C5A79D654D5" modified="2016-09-07" version="1">IQIFVVQAKLNQLSERLGETVTLSPEVHSSSNDPLSARKEINRKGSSQMRKKLKTALRVPPGRLVQSLKVVSDSSRRCRYVRSFVGHRDGIWHVTVSRGTQPILASASADQTCLLWSLDAGSCLAQYTGHVGSVNGVAFGPSTTDSTEFMLATASGDRTAHIWKIAVPGNTQPPVLSSEDDELAEKEQANGGNEMQGGGEIHASSIVRQPLRRLTGHANAVMAVEWFSAGEQLITASWDRTANIYDAERGEIVNILSGHDDELNHCNAHPSQKLIVTASRDSTFRLWDFRESIQSVAVFQGHSDSVTSVVFSSGDKLVSGSDDRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7F1</accession>
    <name>A0A183I7F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UmuC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042575">
        <property type="protein sequence ID" value="VDP23130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7F1"/>
    <dbReference type="STRING" id="387005.A0A183I7F1"/>
    <dbReference type="WBParaSite" id="OFLC_0001567601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001567601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001567601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001567601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26482" checksum="757235EC70DC9489" modified="2016-09-07" version="1">MKRYVNELRENQANNFPSRVHLEHLVDENSPKETICHIDLDCFFVSVALRTRPELIGKPVAITHSRGIEGAGMSEIASCSYEARAQGVRNGCFIKNARKVCPDLICLPYQFDDYREVSKEIYSILLGYTLNIRAVSCDEMYVDLESLCKEMHITNVMEIISVIRSEILTKTGCNASVGIGNTMLIARIATQHAKPNGQFMIKLGDIDEVIKKEKISSLPGIGYNICAKLRKCGFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7U0</accession>
    <name>A0A183I7U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1943 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15802</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042911">
        <property type="protein sequence ID" value="VDP23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7U0"/>
    <dbReference type="STRING" id="387005.A0A183I7U0"/>
    <dbReference type="WBParaSite" id="OFLC_0001581501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001581501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001581501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001581501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29188" checksum="C38C7C149D630862" modified="2016-09-07" version="1">MDTPGSEINRKMEVDFEVSIPRKKLKFGITAPFKTIILDGNLQQMSQSQDYATNLKLLVDDKSYILDGMLKATEAGDRNSYRLNARSVAESVTAAEVAAELQYSISKPYAMLDFHLDKVFSKPITLKTLINPERPKYESKLEYSGPDFNGKLDTSIIRQGMLDWKGTISSEYQIVNHPKHALEIGFEQAFQKRGTNHHFKHALHATSTIFNKFHFQLLSDRTGNNMNNLLEATYLGEQLLANLDVTRGPNNIYKAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I802</accession>
    <name>A0A183I802_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15864</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043087">
        <property type="protein sequence ID" value="VDP24397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I802"/>
    <dbReference type="WBParaSite" id="OFLC_0001587701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001587701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001587701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001587701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8395" checksum="55095044A02384E1" modified="2016-09-07" version="1">MCVYRSKGNKPNKSNHMESIGEWNEEAADSDDNSTMVILMPKSEGRRSEEEDWLRRRGKKVEKRMCECEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8F9</accession>
    <name>A0A183I8F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16021</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043630">
        <property type="protein sequence ID" value="VDP26101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8F9"/>
    <dbReference type="STRING" id="387005.A0A183I8F9"/>
    <dbReference type="WBParaSite" id="OFLC_0001603401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001603401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001603401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001603401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7928" checksum="CC5CE945B05CF242" modified="2016-09-07" version="1">MMESLRNNLVQACDGERITLHCPRNTQILLENIFYGRLVPSDQLCPWPSEQQQLANEDTSCDVVQAHAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VC78</accession>
    <name>A0A3P7VC78_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM adjacent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001305">
        <property type="protein sequence ID" value="VDO32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM adjacent" evidence="2">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="1619" mass="184785" checksum="8847FE21364150F0" modified="2019-02-13" version="1">MIQPEEKPHKGLFRWGSARFRYQGRTQFQSKMASQMFCNSQPVQRSQSVRLAQDDGTKISRSAGLFPRKFSDDDFRGQPHYISDNLCESRSNMSASRKEKDRKFLPVEDTAVVYHPGHYEEEMIGSHNRRFHEPPVEPGDDFVLVHRPKLASTGKIFHQNGAETDILIKEEDIETYPIRYFVDIYHSDFPRSGNGKKDFEVFEHKKHLGTNDVMDKSKINKEKYPTNEKFKGPISRTERSVELPTEPLTAHVYVYNQGYYDTMDPNRTDIDEKGNIRHWLRCYKRPEKSQTKLLKEKNTEFRKKTEKNASKLINDDRTINKSGSINEQENETKKIALIHVKQPSYERQSMQASYNVESSEKRLQQTTYLNESKPTIVESDANKSSSIDTKEETYDSTQLKQTCHLISASDSYRARPGAYGVPSTSYDELLHNIRPEEELPPLPIHEHAVIYHPGISIIKDRKRRKFLIRKEQQKTSSSETSTDVEVPVDERKKYTAVINISDTGKSDLTNAVDVEKRLVDEEIPKKHIKQEMEEKKYLDQMKGSIKVDSKTQKSMHKIEKDTKLADVQNVKSENSHQKMKAVLHLSEGQSKPSSSNMKNETVLRRVEESKGVKHAILPTYNKSDTGRSLERSKKTKLFEQSQNEHILDNTPPSMMLSRIDEISYQPLHLAVKVQNQDQNPSHYYKTFKRAKHEGTVEIVAKENINPASYKLERATYQGPLETTHFIKGLQFAPIHEHSAVYHPGNTYLKTRKIKKRKNASKLQSEPKSSALKAKKTAILYLKRNDTDAKHHKEEKSNSEAFLSKNESPAITYTAETACTIPTNERMKVKKDPFKHRTVSGDVEIVEKCFVKPETYNLITVPYDGPLSFLEYEKELSFIPLQESSSIYHSGISYKKPKKLRDSSTESSSTTSFSSSSSTSSAYLSENHKEFEKKIMLLDKRDISNGTDESAKHKGIFSFWRKSFRSEKGDLPDDKREKLEASSELQFIQQQQQPELSVDFAKSGTSSSPLQIVSKVDSVEEPKADLHLRNKNKKMKANLYLKDEPLTTSENEEDNSKRGKFDLFHFWRSPDKESKISSKKITDMNISNEESPDYTTKFDPSYEEATAGLTTEGKKKPIIVTNKDVSSNVKANELSRSKDMKEESLNRSLVSPSNQDITNVETQENTFIYLKRDSELSDELPLNLKSIPGIPEQEITSAAVTAIPSPDQINVTEMSSNNSENVGYIAKITVKREMRNIGDDLQQDSNLKRKGTNASNDGVNKRSSFVVKGFHLRGPPCDSEEEIATYSSTKYRREKDTQVTEPTETTAISITEKHETDSVNSAAKPITREETEVLRIKKGAMAEGDIKSKGNKKNGSKSSRGHFFSSLWRGSKPKSNDQEEHQKQQKLIKSDVHGTEPTHVNTTSPTSELEYNILRTKIIFDYGCKEVKPSSNISRIEEQIKQDFVPVYDFSYIPTFVSEDSARKPDEIIIDEVADGIGVSGGNEFKQQFNYRSKDVDEYNNTSTLSANQNENWRNEQSAVNMEKQTSMKKMFVSELNREKLDTKEMKKHSIQGTGSETFEVGKLFHRSEISGGETSEEPYTFTQTPPDIPVSVVYTSDSKAPGDFVEQIKQQVTQVRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VZ48</accession>
    <name>A0A3P7VZ48_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RPRD1A/B C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008780">
        <property type="protein sequence ID" value="VDO53700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VZ48"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPRD1A/B C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO53700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="140" mass="15876" checksum="09CE1336E08E0F07" modified="2019-02-13" version="1">MIASFPETIANPALLKPIRSESQAVELLKKIKEAEPVVKEYCKRLAAEMEDRRSLQQLLPEYFGFLKASAVRNDEMLRSVREKVEKLEQEKTSVKEHFDSLPDLADLPASALPPLPSLGELFKSGKNENEDNVEVEKHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X5T7</accession>
    <name>A0A3P7X5T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000100">
        <property type="protein sequence ID" value="VDO25418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="64" mass="7535" checksum="8DFBFF8977FF3BCB" modified="2026-01-28" version="1">MERSVRLTPDIQHYQMMDHSGRSKTIAVMDQHIIKLKRLNRRAGMWGGEKCFGLIPQSWKFSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X8P9</accession>
    <name>A0A3P7X8P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009588">
        <property type="protein sequence ID" value="VDO55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X8P9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="379" mass="40915" checksum="076107C850C16EDC" modified="2019-02-13" version="1">MIYFLLPVYFDSFLQNSGIKQTVALNPPSIHQPITTVGYQLADPVFGSQNERSGAAQPDQFTFPASDAARSSAVACKIRPHDGTSRIWSDVGISGGFKSDNSDGIKSKNGYFVQGTNVSSHPTPIQHVTEARYQLVNPRFVTHKAATSTSSVQFIPSSDNNAGGIGRGISNFVQDSNVPMGAVRYEMAGPIFITENSQSTSRQFVLPISNTVSSDTEHFIQKNNVIQTILTSTEGTTEPSASCDTNDRGSMPSSPIKENSLLRELHSAPSMDKSIEVMLQENSTECYRFVEQFASTMNSRSNVVSNVISAENEITRIAHQLAQSAGDALRSVDGSNVKMGSNDDNGSAIAVDDTGVSKSVENDTIGIRLDNDNKEMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XHR3</accession>
    <name>A0A3P7XHR3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WASH complex subunit 7 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011061">
        <property type="protein sequence ID" value="VDO59177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XHR3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="1">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="140" mass="15588" checksum="4F8ADBF9EC41CA99" modified="2019-02-13" version="1">MHKIFPVTFQYPINRAQGFNAAIRLLGVADDLYLDKLRILITEIGNVMGYVRLVRSGGVEASIQSLGFLPNLDDIPSFESLAVSANLSSESIDAAKVLDNVFDMAKKNINQSDNYLQACDQNFAYLFYDVSLPKNPHIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XYT6</accession>
    <name>A0A3P7XYT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017838">
        <property type="protein sequence ID" value="VDO80360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HWQ7"/>
    <dbReference type="OrthoDB" id="5831964at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="68" mass="7723" checksum="C712E6AD7CCE1106" modified="2026-01-28" version="1">MNNSIMNITNNSGVNGNNDDVTAMDTWEDRRISITLQYGSLKEVLVLERSGNPQHHDIPRYLNCFGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YF17</accession>
    <name>A0A3P7YF17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002093">
        <property type="protein sequence ID" value="VDO35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855638at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="78" mass="9330" checksum="7A00C1F8EB56BC73" modified="2026-01-28" version="1">MFAELLFYCILPVLALAQNTLTDEANEYRQNLWPYVDDTEHWPNDLSNFLYYDPPLKRWASQLRFGKRANWASKVRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C7K7</accession>
    <name>A0A3P8C7K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040310">
        <property type="protein sequence ID" value="VDP14275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="91" mass="9991" checksum="1584E50813955D87" modified="2026-01-28" version="1">MEEIITVMCRSVLPLMAGQFPIEVEGGCEISCFSDGRGKCEVSQFVREVLSIFDGWGKHIISGTVQSKLSLSLVKESFHFAGRNHGIEKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F391</accession>
    <name>A0A3P8F391_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040731">
        <property type="protein sequence ID" value="VDP16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I3G3"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="128" mass="14140" checksum="620FDC515C834A69" modified="2026-01-28" version="1">MAGSETDSLKNRKQSVLTYFTAVYGGVEGPDAMYVKLISSDGHEFIIKKDLALTSGTIKAMLSGPGSYSENETNEVNFREIPSHVLQKVCQYFAYKVRYTNSATEIPEFSIPPEVALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXZ8</accession>
    <name>A0A183GXZ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS108</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01000026">
        <property type="protein sequence ID" value="VDO24566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXZ8"/>
    <dbReference type="STRING" id="387005.A0A183GXZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000010701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000010701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000010701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="46"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO24566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000010701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="596" mass="66481" checksum="1F96D3FAE1EFFAA9" modified="2016-09-07" version="1">MPLNLFGIGAGGVKSQQLDNSSRGNAGTSDGKDWRGSVVKLPNHTVTLEKKLAEGGFAIVYLASDKQGRHYALKRQFISDDVRQLEACRRECRIISCLAGHKNIVSYIDHMILKNNCGVYECSLLTTYYKSSVLQLMNERHLTGRCLSANEILKIFCDVCEAVARLHHSQTPVIHRDLKAENVLIDEHRPGAPVYVLCDFGSATTKVLSSDTQSLQFIEEEIHRYTTLAYRAPEMIDIYSGKPIGTKIDVWALGVMLYRLCFFSLPFGESSLAIQNCSYNFPVEPNYPEELRAIIKVLLEPDLVRRPDIYQVSTLAFEAAGQRCPIGNLNKVPALRLIDAMRNLHHEEVNTTTVASTSTRTSAFTDFDSRVAPKKIATSINPRLRPKPYNNAVRLNLDDSSSHLLNVPISKQQNSSSHPEIDFPNAESSRKSSCGIAEEHGTETLKSSAFRPYSASSESNTKVVIAGFKAEPFETVAVTVASPVNLPVENDDISWNPFLIAPFNSQRHSSATLQNAAMDDHSFGHCFDRLPRHLKHFISSKMEEEDANLEIDENDPFAAAPIHRYQMRFVYDIGTWGFLMFSPLPIASLSAHAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYB9</accession>
    <name>A0A183GYB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zf-3CxxC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS229</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000065">
        <property type="protein sequence ID" value="VDO25068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYB9"/>
    <dbReference type="STRING" id="387005.A0A183GYB9"/>
    <dbReference type="WBParaSite" id="OFLC_0000022801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000022801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000022801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO25068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000022801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15706" checksum="7D7EF374CDAA9165" modified="2016-09-07" version="1">MDSRRMKLLSSHSYSARQKRLLHLSTSVTFVTALGIIFPIVQWFRFNSPYEELTPYQGRKKCYGEFQCQQCKRKWTSQNSVANEAQSCIKCHISVFPHKQLPVDKAVAMGLVKAQRVIPTKLGPIGHGRPPFNTNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYJ2</accession>
    <name>A0A183GYJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000088">
        <property type="protein sequence ID" value="VDO25318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYJ2"/>
    <dbReference type="STRING" id="387005.A0A183GYJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000030101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000030101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000030101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000030101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28329" checksum="E58000F42A86B8DB" modified="2016-09-07" version="1">MNRVRIQFDDNTRNFIGNQRFTALQVSPVSIDSGFSTERNISLNNSAHTDLSIISNAAGQISPQSPRSIHKNTEDENKENIRPILRERRNDTAILFMDGLDSLPERRNNVVNVRCLAYKKENLLRLFSRPFLNNEHENHDEHEREASTSLLSVEHRLLRSSSVTSLHRWPNFWPRFGTYPINGTPRHSPVRRRARILTEEAKFVSLEDLPEVNPFGPNGTPPRTPSRESFVFFENQSPNEVLIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZX2</accession>
    <name>A0A183GZX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS782</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000303">
        <property type="protein sequence ID" value="VDO27045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZX2"/>
    <dbReference type="STRING" id="387005.A0A183GZX2"/>
    <dbReference type="WBParaSite" id="OFLC_0000078101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000078101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000078101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="256"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO27045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000078101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48273" checksum="4B072B8436ECE124" modified="2016-09-07" version="1">MIARNTSICSLLLDLFRLHRSSSVNFSFDFMDGQQQLQEAARKFVAEEVIPVEAKYDKNNQFPWDVLKKAHANGFMNVTIPSHYGGLELDMVTSALIYERFGYGCTGICTAMLTNLLAETPLILAASDEIKKKYLGRMIEEPLMASYAVTESCAGSDVAAIRTYSEKKGDEYVINGSKMWITNAGVANWFFVLTRNNNDPKTPVSKAFTAFVVDADAPGISIGKKEINMGQRASDTRAITFEDVQVSKSHIIGDPGDGFKIAMKTFDTTRPLVAAMATGLAARCLDEASKYALERKAFGAQIANNQGISFMLADMAVNLELSRLMTYRSAWDVTLAQNSPTSYYSSIAKCFAADTANIAASNAVQIFGGKKLSPIFILHLTIHLRRNGFNTEYPVEKLMRDAKILQIYEGTNQIQRIIISRKLITQVRESGTSSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H042</accession>
    <name>A0A183H042_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS852</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000341">
        <property type="protein sequence ID" value="VDO27318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H042"/>
    <dbReference type="WBParaSite" id="OFLC_0000085101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000085101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000085101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552319" evidence="2">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000085101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33610" checksum="752167B07BBAE7A7" modified="2016-09-07" version="1">MFRCSLFCLIFYLGFLILSATMNEIDIRRKIDHSKRPYNHFGRHYEYIYETPSIFDQRPRFRLSYGTIGGDTNTIGDIDTNKQISSAESHRPKKNWQSDVRKHRLENRRNDYTTKFSHNSNNEHDHAWEESESARKHVQKEYEIVRQFADDVFNQAKKELSKLPTFDIPHFQKVFSAVTNEPVLLSDFLFGREANPTLQGQYDRHKIVTNGKQKMKADKEIMENHGKNTVGRWSKNVSRNDASYQMFGILPKFDPRFPFDRAYKLMKGLQPPEMFKFPLTSFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H082</accession>
    <name>A0A183H082_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS892</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000363">
        <property type="protein sequence ID" value="VDO27475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H082"/>
    <dbReference type="WBParaSite" id="OFLC_0000089101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000089101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000089101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000089101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18596" checksum="6508EA4E0E0A8E8C" modified="2016-09-07" version="1">MKNQQEKETRLWRDRSLTHCVDCSSSSNCTSNMKKWYHLFRAIEISFMMDKEYHDGFTTSKVFRIGTVSRKHTAQCNGEKNLFQGETIRTTNIDSGGKLIEDEHRSVHLDRERQYAIYLLFMLQTIKVMTVERNMERQSGFLIVQAGKYGTNKLTDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0A1</accession>
    <name>A0A183H0A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mcl1_mid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS911</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000370">
        <property type="protein sequence ID" value="VDO27539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0A1"/>
    <dbReference type="STRING" id="387005.A0A183H0A1"/>
    <dbReference type="WBParaSite" id="OFLC_0000091001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000091001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000091001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="7">
        <location>
            <begin position="10"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="5">
        <location>
            <begin position="471"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="6">
        <location>
            <begin position="754"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO27539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000091001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="845" mass="95340" checksum="3F89BAA8B6723289" modified="2016-09-07" version="1">MYSGEFAEPRLLHSKGFIQLCVDKSATDNTGSFLSVGTDGDIWMWTGDELDEAEYCPKNIKGRTHCAIAWHGNDIYIGHTSTDDETGIQKSIVSRFEKDSLRMIAPITTFSLDVSSIDISKSGKFLAAGAVDHVLKIVNLEAGDVVHVEADGQIMCVSFNSKDEYLAVTATDGMLRVFDISLLKANEIPKPVAVRICSRIIDIEPSKSRLQLCWDPSGNSLFVPVLGCVKKFSKHSFKEINKFFLTSNSYVIHSHSHYYFNCSCEMFSICCVSSCGTYLASSTMNGSICVWQIETGDLLTCSKYQINGQPKVICSMFWHHLLQDTLFFADTEEHICSLSKCTRKITSNDYNNIDLELQSEKNGTIAKFDDDENSQLSADLGSIKKSYGFDEEGHFHGITDENKKNLQIFTPTEPLISYKPLVVPKAFVTGSTPEYQRQRYLVNLFSKFSAMLLLRYLCSILFLKDTISQKWNQYGTIISSYNGDDARIEINWHDTSIHPEIIIDNTSNFSIGDMTDDIVALASKAEGENLSELQVHCIKAWDYSSRQWSITLPDGESVENIVIGKKFLVLATSQRYFRTFSHAGTQKMVFCYAGPLLTMCAFNDMFTAVVLKGGAYYEDDEPEFNFVATIYKMKTEGWYKCQSLVQTVPISVGRNAKLNWIGYTNRGTLCAMDSKYCCRIFSSSGIWIPVYDFTNNLRTKSDHIFLISFMDYPQSEVRYIYCQGMEYPLVENRSVPAIVKWQLPLCNQDSEKSKLEEKLLLAEIRKCALNSDDEGEKESELSVRFSHDISTAYTKDVVRLFALACKTDRQCRAAEFAAYTHSGQIVQSMCNFASKTRHPLLAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1C6</accession>
    <name>A0A183H1C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium:neurotransmitter symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1286</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000582">
        <property type="protein sequence ID" value="VDO28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1C6"/>
    <dbReference type="STRING" id="387005.A0A183H1C6"/>
    <dbReference type="WBParaSite" id="OFLC_0000128501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000128501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000128501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF324">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000128501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="794" mass="89467" checksum="57BC8F6DADC65021" modified="2016-09-07" version="1">MHLCLGQYSGLTASGAFRKLMPIASGIGWTLVLLALPVSIYYNIIVAWSIYYFWFSLKGFFVGDLPWSQCNPEWPENTPCCLLNGPAECFLQPHAISSPEAYFHYEVLNRVAIHPHSQFTITNATMVLLNATFSGIDLSVANENIVDSALGPIQSHLVISLAFAWILVFLGVFNGIGSIGWAVSITSTLPYLLLGILLLCGMSLPGAAQGLMFLFKPEIGKIWSIPMWKAAAEQVFYSLGIDAGPLISMASFSRYRNNIYRDAVAVVLINAFTSIFAGMVIFSFTGFIAQSQQRPIDDILQRDPLYIAFTIYPGATTFMDMMGPLCAILFFAMLILFSIDAQFAWIEMIVSSIINKFNTADKRTETRLMGGIFLFNSIENMNANWNSFSLSLLQITLICYIYGVNNFITDAGEMLRVSTSLKEILKSENLSIQQVNLWRKLKFFFGPTGGYIRWTWSLCSPCILLFLLITSIFNYQRVAFEDYPLPLRYELIAWFTMVGPLIVIPCTAFRTLYEMWRNRMPLLSAFDCSQWRHKNVEGGELGPKHIADESHDYWSIADPVSRVASSRRPNASLMDEVGYETMVEMINEWAKKNAATLCDRFVDENDAESQQNNKQLNKKFLSRKSLIQQNSTELTLFGAPPTVEISEKTNTVIYRPKKGDQVRKPLLEDNSLKSTKCNSPSPLLSQTRRVSWTGSVKKDNGRPTQLLRRSSSVEKLALDYRLAHFEHMLQHCDSTDHHSFSSISITPIDLDFARNCSSSTISYLDDTSETSSKRNLPILKRPEPINAPTPFTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1K2</accession>
    <name>A0A183H1K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPN2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1362</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000623">
        <property type="protein sequence ID" value="VDO29242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1K2"/>
    <dbReference type="STRING" id="387005.A0A183H1K2"/>
    <dbReference type="WBParaSite" id="OFLC_0000136101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000136101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000136101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO29242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000136101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38178" checksum="74DD4E79E0C055D0" modified="2016-09-07" version="1">MTYKGEAIALLDPLLSAKENFVRQGAVIALSFILIQQTDSICPKVNEFRKTLTKMITEKGEDSITKLGAILAQGIIDAGGRNVTISLHNRNGHPDMPSVVGTFVFLQYWYWHSLAHFSSLAFKPTCVIGLNLNLEMPKTEFRCNSKPSTFAYPPPLEEKKKEENEKVETAVLSVTHKKKSSVLDRSSTAVVKEEAKTKEEKDKEEEMEVDSTPAAAITAVADSVTAVPLSAIANLEHKLPESKRLRFIRVIFSKEPEPTSYTLQNPARIVRLQLKTLQMTENNRYKPLKALSQGGIIMLHDRKAGQEKEEIVALAAAGGTRVEGKDSSEEAKPHTPFEINITSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1P9</accession>
    <name>A0A183H1P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1409</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000655">
        <property type="protein sequence ID" value="VDO29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1P9"/>
    <dbReference type="STRING" id="387005.A0A183H1P9"/>
    <dbReference type="WBParaSite" id="OFLC_0000140801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000140801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000140801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053341">
        <property type="entry name" value="Oxidative_stress_globin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768">
        <property type="entry name" value="GLOBIN RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768:SF2">
        <property type="entry name" value="GLOBIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="3">
        <location>
            <begin position="57"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000140801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30539" checksum="DBB74E1C5F3B776F" modified="2016-09-07" version="1">MNADNQPNSSSEVPEASDGSTTFATVVKELTENVDYLSVDNQPITVGQTGGTKHKKWLSKSQRVTIENSWKRATKSNAREQVGIELLGRILTARPEMKHLFGLQKIPEGRLKYDPRFRRHAIVFTKSFDYIVKNIAYREKLEQHFQALGERHTTFQGRGFDPGYWDTFNDCMKQTVSFWDKGKGHKTANTWNLLISFVLQNMKIGFNRANSRHLRRVPRPLQHHSTYSTSSSTRQGIDPIQFYKQFCLQQKKSSKRRLLQLSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H255</accession>
    <name>A0A183H255_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000762">
        <property type="protein sequence ID" value="VDO29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H255"/>
    <dbReference type="STRING" id="387005.A0A183H255"/>
    <dbReference type="WBParaSite" id="OFLC_0000156401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000156401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000156401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000156401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8312" checksum="1D3189D653431F62" modified="2016-09-07" version="1">MSLLFVHLKWRLHFEFVTCSDFNEEVKEGLWQAPANVNIETMAWDLDIKIFPCSPHNAALTLRSPTAPASIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2E6</accession>
    <name>A0A183H2E6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1656</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000826">
        <property type="protein sequence ID" value="VDO30336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2E6"/>
    <dbReference type="STRING" id="387005.A0A183H2E6"/>
    <dbReference type="WBParaSite" id="OFLC_0000165501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000165501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000165501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029445">
        <property type="entry name" value="INTS5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14837">
        <property type="entry name" value="INTS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO30336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000165501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="820" mass="92659" checksum="314BC88064E256BE" modified="2016-09-07" version="1">MLQRYMVDIYAITGAVDDIGMVYRNLRPIWANNTVSHLVDPCIKILSKIPSSRPAVLNYVGMLTHEATHLYLSKKENPHIAADSANIERAVRKLTSEFRRLLIRTQSKGFAFDILVWACNLFVEICKYNYERPIAKNAGISPPSLLGLFDSCPAVSSVIKLTDKAIALLLNTTPDECLSTLIDASAHGFCFAWIWLHIAVSFPDTIVAHLLKIGMQDFKRYLNAVLTNQAPIEVHENHKQKFLPICDVFTFLASQNNAELRNAMRELISNDREVLENPTATSEQLQNLSLPFLVKIVANSAEVLRFLVHNVYDLITTSFIISGSKYVSQLNKQCLLPLLPNMEYTYTAFMRQIAFYLNSDALAHIVELMLPIAFNDNIFEKLGNYDQPFQQSMKDSALQILTEIIGMVVSLVHNQVMHNVGESALLKRCASNFEVLEEAVQYSMAGGEKSKLFIPYVHAFCIASGPVRTTEVIARYIIEAKDDEQLICLIALLTSLIIFAPNTSEDAIINFFANRTTLMLEKKRESAKKFAQINSLSSAAFFKDDFYDIKWLYNLRTLNEWEKMADDEHAIKSIRFEMSKHYGELATEILRWALDVLSSLKRKEKTDESIKAMRDSTAQAVLSLCSSIGPPSVLEPKYPYKLSAQFASLIIFLLDYVGREDDPTGLALFTNACTCASEFLASQVGYVREQFIIHLLDEAFAKAFSLFGCSSLNAWETELQFSSGFQRTNYSTDILDADEDDELEESLFDLARKLPLYQQKAVHLAHSGIIGRGAKRLEVKNVKGGNMMRRLVFFECLQRFCSTVGPDRNLIPFQQVHKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H380</accession>
    <name>A0A183H380_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001031">
        <property type="protein sequence ID" value="VDO31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H380"/>
    <dbReference type="STRING" id="387005.A0A183H380"/>
    <dbReference type="WBParaSite" id="OFLC_0000193901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000193901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000193901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000193901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23675" checksum="BAB257B7F27E2938" modified="2016-09-07" version="1">MSLYDIFGEDPVHEKGDDGRSSKKGLPSALRLLQSQIHIKKTQLSQQRSVVTPVVDLSAKNRPSKASFLRPHKAMPLGDGPPLSFIPKALKEDKVFLFGEILVEDEYNPTAPTDYAKHKQKMDERRAKEKIAKEIAERLNREHQEEIAKRTAGAAIAPPKILMEEDSKVELPTNSDGNTASEMPPPSFIPSFGAGKGLGVAANIMSKFGYKGIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3B2</accession>
    <name>A0A183H3B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HRDC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1972</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001051">
        <property type="protein sequence ID" value="VDO31436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3B2"/>
    <dbReference type="STRING" id="387005.A0A183H3B2"/>
    <dbReference type="WBParaSite" id="OFLC_0000197101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000197101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000197101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="227"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO31436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000197101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="594" mass="68950" checksum="D4FB26E8A8F339C9" modified="2016-09-07" version="1">MTEPLKTLSDTELIYIDTTEKLKTLRDILNKQQEFSVDLEHNAQRSFLGLTCLMQISTRQTDYIIDPFPLWNDMHILNEPFTDPNILKVFHGADSDIAWLQRDFGIYVVNMFDTYKAMRVLNYSKFSYQYLVQSCCNLTLDKKFQKADWRLRPLTDAHKTYARSDTHYLLHCYDQLHKKLLDQGDAVNNLLELVYSESAQTCLTVYKKPTFESDGYEKLLVGRKPLNSRQQFALAALWKWRDERARADDESPQYVLPCHMMLQIAEVLPREMQGILACCCPVPLHVKQDLHVLHQIINTSRDQPLVKHSAYVPNIGSLTLEGVTSQLNKMNAIKAILSCHLDFSSTKYNEEIRDIVTQKVDETICEDGAIKGSGDGLLSTELYIIGEDNEKESKHLTKVMEKLEDWATPYECYRIAITEQSSKANIESKRKEEDPTKSGQSISKKKKLWSHLDSATNRPGYTEQKVSASELQLESEQRKNAEREMNIYEEMTLTKKELKKRKKRGAREINIPTTQEASRTRKNSSEVVRKRGRKSNWTDAVENCDQRVDYNSFNPDIFNKNAAPISDTYDPFKHWKREKCKSRRGRMMQRGPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4F8</accession>
    <name>A0A183H4F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2368</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001349">
        <property type="protein sequence ID" value="VDO32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4F8"/>
    <dbReference type="STRING" id="387005.A0A183H4F8"/>
    <dbReference type="WBParaSite" id="OFLC_0000236701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000236701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000236701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000236701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31508" checksum="828C12B9045B0578" modified="2016-09-07" version="1">MGEAHVKVQKCKNSKKKPVNILKTQSNVKATSRNFSLSSIVSNRQVHSSLEVPSVLYPYRPARSEALCVQPSSSMIKDYVSRKDVEELLVEINNALALVTDQDYSELREKIAHHLNNLHRENCRFRQTLHQLRSELDSLSNNSTVNRCNLLMKQNSELREQKVLADIKCEAQMEEARKLLERIRILEVRNKDLEDFRNRLIKQKRQKYLNGERKYPHIDLVNDLSRMEAEDLMDIELDSLLLNGNGNEVVKNDKSNNDKVKWGNDAWMLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5P2</accession>
    <name>A0A183H5P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aurora borealis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001706">
        <property type="protein sequence ID" value="VDO34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5P2"/>
    <dbReference type="WBParaSite" id="OFLC_0000280101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000280101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000280101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000280101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41391" checksum="85B0970D1B35EFC5" modified="2016-09-07" version="1">MRIKMVDDLTMKAMEREGAGRRSVTYKGHFQWPSKSSVLGTPERKRSRRSISFADSGLGSSIFGSPPSKSITMPDTATTLKTPTRKKSPNTNSPSSQSPLKQVLLSFLHVSAFSDAFCPPENCSPPSKFRLSDPGKAVEYRFSGTSVPENETPINMADDALNGAVPSTSFKDSSFRSACRSLEIQLTCSLTRSSLDDENDDNVTDSAISYGMVETPSKGFKNEMNMAAGFIDDSFSLLTSTPLHIGSNDDISRNHAFIPSHYTIPEQANGPLESRFEVGWSLKRSLCEPVDQFRLHTASFLSPVKSTDAETIVLPVTRISQAEKINPSQRRIEQFYPRLISNSTVANSSRVCLRESNYNNRPFRPPTKALKVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5V0</accession>
    <name>A0A183H5V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2861</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001752">
        <property type="protein sequence ID" value="VDO34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5V0"/>
    <dbReference type="STRING" id="387005.A0A183H5V0"/>
    <dbReference type="WBParaSite" id="OFLC_0000286001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000286001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000286001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="142"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000286001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33555" checksum="FDC316A638404D46" modified="2016-09-07" version="1">MIEEEEDVTPLGQLKAAHRKERKELQSKITSMKHSIAKGDKKRKKEIVAEIAKMEEEVKERHEKELAELELSLPEISVEPTVVEQNQEKEPRISKAQRRREKKAELNRKREEAAMQARIDAENGPRKLESDEIERILMDRGLMIYDIEPDGDCLYNAVAHQLSLVTSHQFRGAEIRQKAAAYMRTHKDDFLPFLIDDNGEAVDEIEFEEYCMKVEKCCTDGGVWGGEPELRAIACALERSIEVIQPGGCILPFGEEYSDRKSLVITFHRFAYNLGEHYNSTVPNTIINFPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6L3</accession>
    <name>A0A183H6L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3125</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001994">
        <property type="protein sequence ID" value="VDO35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6L3"/>
    <dbReference type="STRING" id="387005.A0A183H6L3"/>
    <dbReference type="WBParaSite" id="OFLC_0000312401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000312401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000312401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000312401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9586" checksum="A518EC81382ABA42" modified="2016-09-07" version="1">MDVNDNEPYFEKKLYVGSVAETASIDSAVISISALDKDTEASDNIFSYELINEHQYFYITTETGSSSTSVGVLRVKKVFFFFHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7F1</accession>
    <name>A0A183H7F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002270">
        <property type="protein sequence ID" value="VDO36418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7F1"/>
    <dbReference type="STRING" id="387005.A0A183H7F1"/>
    <dbReference type="WBParaSite" id="OFLC_0000341201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000341201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000341201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000341201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11856" checksum="6EE958DE0137FD7F" modified="2016-09-07" version="1">MVLSELVHFLRRRVRPPESESEHCLLDTEPTCCSIVRLPSPQRQHIDALLYHCLTTKILTFVCTPQITHTRIHTLHPLIQMACVFLKRPYLKDRKASNQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7G7</accession>
    <name>A0A183H7G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LsmAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3429</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002284">
        <property type="protein sequence ID" value="VDO36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7G7"/>
    <dbReference type="STRING" id="387005.A0A183H7G7"/>
    <dbReference type="WBParaSite" id="OFLC_0000342801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000342801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000342801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000342801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52878" checksum="335E09B6E0E87BFD" modified="2016-09-07" version="1">MEEEEEFKMSPKSAGSELNQRISPVLHNPSSLTQKICMDSSVNLPETSLVTHTTRSLYDVDVRHVCEIMEEVDRSKRLPKPIGFEWEQKMARMNYSVNRSETSFARGTEGLLYDFDWHNCETKKEIERIKMLSKHTDFELKQKTVLIDHSVNRSETSIARFTEKSLPAEVQLDETEPRKSFSDNQIDALNFQLEDLTVAAPTPSTDASVITVSTVSDNKPITSTFPESDRISPSTDVARTVFSDTQSPVTSTAVCEMEQTHQSSTVISAKTTEANAPTSNWKQFTWNPDAPPFIPHNSTSNYNTGSQNHHSTSYGIGTSDASITFMPSHITAPIQMQTLAFADQQTLSGQNMPSIVHAALPQMFSSGYANAYNAATPVHYNIPVVQNVPNSAAPMITATNYLTGSQQIYSNANRSGYVTYVPSYYNAPAAQNMSNIAAPMTTATNYVTRSRQIYSNVNESGYGTYVSYYYSAPVAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H806</accession>
    <name>A0A183H806_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Importin beta-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Karyopherin beta-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3619</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002484">
        <property type="protein sequence ID" value="VDO37178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H806"/>
    <dbReference type="STRING" id="387005.A0A183H806"/>
    <dbReference type="WBParaSite" id="OFLC_0000361701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000361701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000361701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="12">
        <location>
            <begin position="150"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO37178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000361701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61382" checksum="BFB02FCE34855859" modified="2016-09-07" version="1">MDGDDDGDDDSSTEWNLRMLFDAFLYDVCYCHIRKCSAASLDVLSSIFNDDFLPTLLPILKETLFHNNWLIKESGILALGAVAEGCMSGITPHLPELIPFLITSLQDRKALVRSITCWTLSRYCHYVVQQDHNMYFKQLLKELLARILDGSKRVQEAACSAFATLEEEANLELVPYLPEILATLVEAFNRYQAKNLLILYDAVGTLADSVGPNLNEPQYVETIMRPLMAKWAALGDDDKELFPLLECLSSVATALHEAFLPFCEPVFQRCTALIGRCLQQSQLAMERPSEYDMPDKDFLIVALDLLSGLAEGLAEHIDSLVGPSQIIALIYQCAMDSSAEVRQSSFALLGDLSKACYHYLQPHINIFLPILAQNLDPDSISVCNNSIWAIGEIAMKMGEDMRPHVLGLIPALMIVMNREKGPKTLLENTAITLGRLGISCANEVAPFLSQFIRPWCLALRNIRDNEEKESAFRGLCNMITLNPAGVLAEFIFLCDAIASWNNPQPELKMMFSRILHGFRQQVGDLNWTAFTSQFPIPLKQRLANQYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8G2</accession>
    <name>A0A183H8G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3774</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002631">
        <property type="protein sequence ID" value="VDO37700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8G2"/>
    <dbReference type="STRING" id="387005.A0A183H8G2"/>
    <dbReference type="WBParaSite" id="OFLC_0000377301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000377301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000377301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO37700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000377301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48458" checksum="AE0F08A729B48008" modified="2016-09-07" version="1">MQFHGERRATATADYGKWKPSDLQLPHMSTSEDRTLYVQNIPETWDKWKLLNIFRRFGRIDNIKILKKHEDSLACAFVYMMTVADANSVITATANNDGEIQLPELSKPLKIQFVKQKGDASSKTELSAAINKEAERMKRLFVFSIQLNERIKTFFLIVSIKICFSYFSIDAVELGLTGGMIRKSIIYNDRLHRHAYLPVGKPLQIELVKPIAKFLHWPMLFYVITETHECETENLIITNRDLDSNLVAHFKRAAQVTYVVENELLVAAPNKPGQVPLRCRVLEELDDKKIRIYALDLGQTLVVQMSDLKVISDYLASIPARAVPCMLYGITNPTSTFAQNASCLLESIDHLIILVVSFQGAVALVRAFSLNGSSEIAKILANKDLCDYKPPSKRKTYSRETLLFLREKQVNAYEYYYNLHCLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9I9</accession>
    <name>A0A183H9I9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4152</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003044">
        <property type="protein sequence ID" value="VDO39102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9I9"/>
    <dbReference type="STRING" id="387005.A0A183H9I9"/>
    <dbReference type="WBParaSite" id="OFLC_0000415001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000415001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000415001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="476"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO39102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000415001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61264" checksum="2EE01B897ADAAAF3" modified="2016-09-07" version="1">MFSESKGKYFRGSGFTDGQGPAEVAANHVIFRTDAGSEQRNYMQQSASKHLRLDDRRKEFGNCFDTCGAAAFSSTEKVFKATGKERNSESGIRGTTPKCDVKSLGQLPPADTFRTFLTDERRQENESSKRNLEVLKKKTDQVYAEELDPVKAKFGKEKNPFKRVCDGDLLFDKEKLYIKDRTSGKLKSKESEKERKKERQHYSLEKVKKSGRERETPHIQNVYGKERDQTRRDEKGLGIVGEKKEAQQDRQKDESDRGKGKKMGLVGLRSGNISGDCIAENDKKYREKLGKITGSGERRKRKGTNRDEKSGKDMEKDAKGNAKEKGCSSETKDKGKHHSKKTDMEEKVKGRDKDFRNVEKRTKHSSSRGREHSTGKSSKEIEKVSSGEEGDFGGSSYVKTKNSSKDALTGESNNSHLPYNPLLKTEQVIFAKEQLSKRCSADSDIFGRISPAAESLTKSSDKKSATLDSDDSLDNMWICPECSVAYVEGATDMVGCDACDNWFHWNCVGLLVAPPDDAPWYCQNCAKKKLKKKSLSKSSNSKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9T7</accession>
    <name>A0A183H9T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4249</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003148">
        <property type="protein sequence ID" value="VDO39414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9T7"/>
    <dbReference type="STRING" id="387005.A0A183H9T7"/>
    <dbReference type="WBParaSite" id="OFLC_0000424801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000424801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000424801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="8">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000424801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39104" checksum="C9E14093559621FE" modified="2016-09-07" version="1">MGRPCNDGMLRVGSPITCYLGKQFFRSLLSTHRKTSLSVHFSLVHSLSKKCPLKASPSILLPSDQPRSSLLERSFGSSSVLYAISDKDGDRGKEDSSKESDNGRLRKFVTGLLIGSVVATVIMSASTSMWQTRYTNQLTVQDFLTYIVPSGQIEQIVITGNNVARVVMKPGPIENLPFSECGYNMFRPGVGWQKVYVLTAMDAKKLEADIRAVETSIGRSPEQWAPVAVINTSLEGFLDLLLLLLLALMLFGASKSLPSMKNSFQDVLGLKMKLNIIKPNDINAQKIRFKDVAGLHEAKVEIKEFVDYLKHPEKYMKLGARLPKGALLTGPPGCGKTFLAKALAAESSVPFISMNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA15</accession>
    <name>A0A183HA15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RyR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4327</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003236">
        <property type="protein sequence ID" value="VDO39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA15"/>
    <dbReference type="STRING" id="387005.A0A183HA15"/>
    <dbReference type="WBParaSite" id="OFLC_0000432601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000432601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000432601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ryanodine receptor Ryr" evidence="1">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000432601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29017" checksum="46AA0F0DD97A8792" modified="2016-09-07" version="1">MTPNILVGVVEGSSQFRRWYYEAEVEHIEQMTSMQPYLRIGWANSMGYKPFPGSGDGWGCIGIGDDYYSYGFDGRCIYCGPNFSCRFMFGGTEGRLRFGPPSGFSPLIEAAANQLEIGECLSFGDIAKNMYTGPSILRQNTEPFVPVLVDISNVVLPEFAMEIHEKLAENLHELWAMRKIELGWSYGEVRDEKTRRHPCLTSFQQLPQNEKTYNINLAIDTMKTIEALRYHMILDEPAVRMRCLRLPQKYEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAG6</accession>
    <name>A0A183HAG6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS4478</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01003413">
        <property type="protein sequence ID" value="VDO40112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAG6"/>
    <dbReference type="STRING" id="387005.A0A183HAG6"/>
    <dbReference type="WBParaSite" id="OFLC_0000447701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000447701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000447701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20338">
        <property type="entry name" value="BRcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000001">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO40112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000447701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46396" checksum="A9E64E187B1075EC" modified="2016-09-07" version="1">MVRINNDHTLSNANASSVSLLDSRILQDSCSSSVDEKSQFVNSEDEHGFGVNNNETDFEQTLQDSSNSGAGATSETSSTQPVAQHSPLSNSSALSRKYWECPLCFIRQPSANFPRLSCCNHRSCKSCLVQAKRNSFFTSFKISIYLQYLQVEIMESRVQITCPECSEMLHPTDIYYLMAHCPNLIQKYETFALRRVLMMDPDTRWCPAPDCTYAVIATACAACPELRCERPGCGALFCYHCKGPWHASQTCDEARKERGEIYRRSVPQLSAAQESILKPGDIKACPRCRTYIVKMNDGSCNHMVCAMCSAQFCWLCLREINDLHYLSPTGCTFWGKKPWTRKKKLLCQVGTLIGAPVGIALIAGLAIPGIIFGVPVFVGRKVNQRFAYLTKIRRRCLTAGSIIGSLIVSPVLAVMAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAL2</accession>
    <name>A0A183HAL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rb_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4523</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003466">
        <property type="protein sequence ID" value="VDO40223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAL2"/>
    <dbReference type="WBParaSite" id="OFLC_0000452301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000452301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000452301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000452301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18189" checksum="75AEE8B4FEB557AE" modified="2016-09-07" version="1">NRRESARRSLRCCSPIPSWRSDKEAIYISGASWTRPSAPYSVITAPKKGKQTRSCPGGVSIFPIKSSNNNKKYDSVESKNVGIAADVRNLDAEIKTSEYGSADPSPTDSSQSAHMPFLESKTDAQFKAEIQKYEFEIRRLRKRLKEERHYFKGQIIAVQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAX0</accession>
    <name>A0A183HAX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003615">
        <property type="protein sequence ID" value="VDO40570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAX0"/>
    <dbReference type="STRING" id="387005.A0A183HAX0"/>
    <dbReference type="WBParaSite" id="OFLC_0000463101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000463101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000463101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000463101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8814" checksum="3548D07438F9FE1A" modified="2016-09-07" version="1">MADAFRATRFNLETEWKNNFPRMRELDRDELFDKAKGEILDEIVNLSLLPAEQWEKLLKKKLWNTVSHLFYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC23</accession>
    <name>A0A183HC23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5035</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004127">
        <property type="protein sequence ID" value="VDO41837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC23"/>
    <dbReference type="STRING" id="387005.A0A183HC23"/>
    <dbReference type="WBParaSite" id="OFLC_0000503401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000503401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000503401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21019">
        <property type="entry name" value="Spectrin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000503401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="40086" checksum="E8D559D0431C76DC" modified="2016-09-07" version="1">MEKIKINIRLYRIYFQAEISAEDTHEYCELLSILESEYQQLRDLSAGRMLDLDTLIAFIRGAQHEIVWINEREDIEVSRNWSDIKQLDLPMLQNYYKQLLHEIELREPRFNDVHNKGAALLNQGHPAIHVIEFYLNAMQRKWDWLLALSKCLEQHLRDALNLNSFMEDANAAEEWMIKQSEMLARKYNKSEFSLEEGEQMLRELDEISELIKKYHSILMTLTERSSQISPLWQRGEQIQRPISVIALADYTDKDITIREGDECILVDNSDLIRWKIRGPSSAEIFVPSVVFRILPPDSRITAYLNRLHTNLEKLRRLWAQKHRMVRYNMVLNTMAQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC50</accession>
    <name>A0A183HC50_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5062</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01004160">
        <property type="protein sequence ID" value="VDO41929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC50"/>
    <dbReference type="STRING" id="387005.A0A183HC50"/>
    <dbReference type="WBParaSite" id="OFLC_0000506101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000506101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000506101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO41929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000506101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26094" checksum="057568A909C36015" modified="2016-09-07" version="1">MVHVFCPAEAANVIKGYSPELMVHPSYDKGTIVESLHRIDAFILGPGLGREEKTLSVVECVVESARKKNIPIIIDADGLFLLAKNLNIIHDYEQAILTPNHSEFNRLYQSVFKVDKIDRGKIESGEAARQLANHTGCTIFQKGPHDIITNGEELYREESTGSPRRCGGQGDLLNGALAIFSYWAIRKNDSKPMISASIAASQLIRWAAEVSFERNGRSSTASDMIAEIPGLIKLCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCB1</accession>
    <name>A0A183HCB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5122</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004237">
        <property type="protein sequence ID" value="VDO42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCB1"/>
    <dbReference type="STRING" id="387005.A0A183HCB1"/>
    <dbReference type="WBParaSite" id="OFLC_0000512201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000512201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000512201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000512201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25539" checksum="326C394C118AC4C6" modified="2016-09-07" version="1">MTRIRQIIALRKALKAGPLLPPISKRLLVKHSSNRLIGIHPFELKFLESFDVQHYSREKHSGDGLCTNKVTARDILEIDLRISELKTDLFAFNDIVCLISIYKNSSESPWKLVTTTEIISKNTDTFSIPNAFSVEYTFKRDQYLKIEICDCNEDEVTIIGATTFFVTEIVTTLPNLSKPLIQSNGDKHIAVLTISYTAQPKVQTILLQFCGKNFPKKGFENTQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCE0</accession>
    <name>A0A183HCE0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004282">
        <property type="protein sequence ID" value="VDO42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCE0"/>
    <dbReference type="STRING" id="387005.A0A183HCE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000515101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000515101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000515101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000515101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14391" checksum="EDF1099D8143BB3E" modified="2016-09-07" version="1">MYSRRINAMRSTSPPLYYIIVIEQIDVKRIIASATLFLEFKFTHEAGCLGRIGDIVVDKTVLDLFFPKILFQYLASLARHIGVFKLLLECNVDIISCYEELGFKKDTKDISLALNFKKKKQRGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD66</accession>
    <name>A0A183HD66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5428</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004657">
        <property type="protein sequence ID" value="VDO43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD66"/>
    <dbReference type="WBParaSite" id="OFLC_0000542701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000542701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000542701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000542701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10753" checksum="D7B9E59FC8C2CBBB" modified="2016-09-07" version="1">MLSRCFQNCAFTINNNIRRAVRIIKRIIKEKCCDSFSSAYAFTADPNEVNHKFYTIKVVLTITCAMDTLMKRNTGLKEKVYIEVKEMKCFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDI2</accession>
    <name>A0A183HDI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PI4K_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5543</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004820">
        <property type="protein sequence ID" value="VDO43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDI2"/>
    <dbReference type="STRING" id="387005.A0A183HDI2"/>
    <dbReference type="WBParaSite" id="OFLC_0000554301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000554301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000554301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI4-kinase N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000554301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48327" checksum="E18EF65438C7C34F" modified="2016-09-07" version="1">MILSFKKYIAGINPGCTGNFRLTVEAILKSLNDASGCTNDTSPSLYLSSLHLRSLYLGKVKGMIETFKTEVETKSQEQLADLFEQQLEKACANGCDKEISESILKLAALFVLMKEISNQKLDGRLLHILVFIPLKNFTASTMRLCVIAWNWILVTREEIQLQFLREMATCWTIASQDQLGIFQRDSEIVSPLSLQCCSAPKRSHIVPHNIWICFLVERVDIAKYSSREQLDILELMFVQTLPLNVGRLRVDVNSPLYISSDSSFNRVDLAHVTMTRNVEAIGLRCHLLNCVLSMIQRDSISFHISKNILRQRVYCAMLDYFSVAAQTPTQNSAQLKNDIRWLITFWNTLFSDVKYIKKEVFASIDNELNLESLQQILNGNYKSETTYNRADMQTRHALTTSGYNWVTLVAAQGRATLLQKNALSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDY3</accession>
    <name>A0A183HDY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005037">
        <property type="protein sequence ID" value="VDO44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDY3"/>
    <dbReference type="STRING" id="387005.A0A183HDY3"/>
    <dbReference type="WBParaSite" id="OFLC_0000569401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000569401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000569401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000569401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13834" checksum="0844E2DE42258C75" modified="2016-09-07" version="1">MEEDGVLSSGFLLDYATRRKLAELFDVPTDPTKDWRGLAKKLNLHRYIQYFATRPGLSPTSLILDLWEAVEFGSQRAVLDLLQTVRIMGRPDAVMIMSKIWGRYIERSIFQQSYELLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE80</accession>
    <name>A0A183HE80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5792</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005171">
        <property type="protein sequence ID" value="VDO44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE80"/>
    <dbReference type="WBParaSite" id="OFLC_0000579101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000579101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000579101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000579101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8029" checksum="6B516BC8BEA393A8" modified="2016-09-07" version="1">MLGEENDKDRENLHHTCNMDVSIEFEEDLTQVDNGEMETLKTSNATWDNSLGSSEVLSIQDDIVQTGSNIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEM4</accession>
    <name>A0A183HEM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maelstrom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5938</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005380">
        <property type="protein sequence ID" value="VDO44869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEM4"/>
    <dbReference type="STRING" id="387005.A0A183HEM4"/>
    <dbReference type="WBParaSite" id="OFLC_0000593501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000593501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000593501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000593501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18526" checksum="642654BD066CF6E8" modified="2016-09-07" version="1">FTPIIRSSLRTGNTNRPQQIQPIFVGDEKGRRWLVCLNHECEKIRASLEYLKEAQGLSYDGFPTTEDRFWYADAVVDALAEYADGTPNLEYKLWMDIFGKRQPFEIDALQFNTPWERRVNVFCRLHGVTRNCCCASATAIRSCFAMFFALRELLNLTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF94</accession>
    <name>A0A183HF94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6156</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005706">
        <property type="protein sequence ID" value="VDO45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF94"/>
    <dbReference type="STRING" id="387005.A0A183HF94"/>
    <dbReference type="WBParaSite" id="OFLC_0000615501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000615501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000615501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="7">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000615501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11746" checksum="B6A26656BA896107" modified="2016-09-07" version="1">MEISNPNQSGAVLLNSKLVINRKRQEGNPVLKYIRNVPFEWADIKADFEAGKEMGILYLSLKWHKLHPNYIETRINNDGIGYAVKVRWSKKIRNFNTNSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHX6</accession>
    <name>A0A183HHX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7087</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007153">
        <property type="protein sequence ID" value="VDO49257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHX6"/>
    <dbReference type="STRING" id="387005.A0A183HHX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000708701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000708701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000708701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000043">
        <property type="entry name" value="Acyl CoA DeHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="5">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO49257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000708701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26823" checksum="C690FCC8F070B335" modified="2016-09-07" version="1">MLRKLQYCSIQFQNRFISLVLSDTEREYRDVAMKFAKEKIMPVAAHYDSTGEFPWDIVKEAHRIGLMNPQIPKKYGGLELTNLETVLVVEALAYGCSAIQLCIMGSSLAVAPLNIAGNEEQKKKYLGMLTAEPIIAAYCVTEPSAGSDVSSIKMKAEKKGDSYILNGTKAWITGGGLAQWFFVLARTDPDLKTPPGKAFSAFIVDGDTKGISRGKKEQNMGQRCSDTRTITFENVIVPKEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI24</accession>
    <name>A0A183HI24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7137</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007246">
        <property type="protein sequence ID" value="VDO49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI24"/>
    <dbReference type="STRING" id="387005.A0A183HI24"/>
    <dbReference type="WBParaSite" id="OFLC_0000713501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000713501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000713501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000713501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9574" checksum="1E76BC54A9264024" modified="2016-09-07" version="1">MCDLLRQYKWRQLIQVYRLSSRPIPLTFDKFGSEIETECRVSPVVILHGLFGQKTNWQLIANNLCRLLRTVIFTLDLRNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI54</accession>
    <name>A0A183HI54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007304">
        <property type="protein sequence ID" value="VDO49663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI54"/>
    <dbReference type="WBParaSite" id="OFLC_0000716501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000716501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000716501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056655">
        <property type="entry name" value="DUF7753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24936">
        <property type="entry name" value="DUF7753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7753" evidence="1">
        <location>
            <begin position="103"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000716501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18381" checksum="418D5782D9BA8316" modified="2016-09-07" version="1">MYYNYYCDICESLHQLQSGRENSALTNQLKGISCPKYPGFYTFRKEFCINDWSAFDSDGDCQFDFFQDEKFSNYRTAFSSLQQIGYGTVVAKLRLAANATGKIAERKRIKEELIEETVRKELEERRKTWNINDEQFEEFRLWYTNNRNNIWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIH7</accession>
    <name>A0A183HIH7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7289</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007496">
        <property type="protein sequence ID" value="VDO50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIH7"/>
    <dbReference type="STRING" id="387005.A0A183HIH7"/>
    <dbReference type="WBParaSite" id="OFLC_0000728801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000728801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000728801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000728801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15510" checksum="9273418936E51ED1" modified="2016-09-07" version="1">MICVDNSEWMRNGDFAPTRLQCQQDAVNLVLQCKLRANPENAVGLIAMAEYGKMHNCSTVEVLTTLTQENGKLFMKLHQVEPKGSSDFINAIKVAHLALKHRQNRNHKMRIIVFVGSPIDHLNFAEVCLLFSICCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIS2</accession>
    <name>A0A183HIS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS7384</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007683">
        <property type="protein sequence ID" value="VDO50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIS2"/>
    <dbReference type="STRING" id="387005.A0A183HIS2"/>
    <dbReference type="WBParaSite" id="OFLC_0000738301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000738301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000738301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000016">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily A, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000738301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16961" checksum="0E9BD999DDCD4393" modified="2016-09-07" version="1">MNGGGRMNGPVDTTLYDILKVKPNATEDEIKKSYRHLAKEYHPDKNPSHGDKFKEISFAYEVLSNPERRGVYDARGLDGIKEGDSGGFSGAEDLFSTLFGGGGLSSFFGGSGGRRRKMRGQDMAHPLKVSLEDLYNGKKSKLQLSKRVICSSCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ57</accession>
    <name>A0A183HJ57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007907">
        <property type="protein sequence ID" value="VDO51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ57"/>
    <dbReference type="WBParaSite" id="OFLC_0000751801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000751801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000751801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000751801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21297" checksum="A04178E23AAA7C5C" modified="2016-09-07" version="1">MRKRWGEKLTKGGKIILYTFFPNPSGIPIKNEYSVIEGYKHGQTRKVGLMQCPGHWEKSVELVDNSQKRPVSDVFEDNIENDAQRFLDLCESASFTNRISYPRLGALFFCSTNHEVIRWNSSNLTLREIKQLTVPTDRLAAVVLTTRALVRNTDKREQQRMTNEAMIDCLDIFWQFYIMFSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJA8</accession>
    <name>A0A183HJA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007994">
        <property type="protein sequence ID" value="VDO51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJA8"/>
    <dbReference type="STRING" id="387005.A0A183HJA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000756901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000756901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000756901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000756901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23652" checksum="775BAEA12A4B4D1F" modified="2016-09-07" version="1">MQGLTGINQIELDPDASPHEPSFACHLYPWTCGLNHSQVITQFIKSVSRNVTNDTTTKTSENSKPVINLAKAPRKKLTTEALTTTTTTTTTEAPTTTTTEAPTTSTTTTEAPTTSTTTEAPTTSTTTTEAPTTSTTTTEAPTTTTTTEARTRRVTIPTTEEPSTRPIRYPGQARTAQEAMGNLKKAIHQAVCDFDIQFQLKRSNILKDILLITTLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJJ4</accession>
    <name>A0A183HJJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008136">
        <property type="protein sequence ID" value="VDO52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000765501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000765501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000765501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000765501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9488" checksum="91F260E2B39CA9C7" modified="2016-09-07" version="1">MNKEQLRQRGNPRHDLILKVRGGIESKNSVCSRECGAGRSQEIQPVQLIIAVTGQSTEYDLNKSKESTADIWTAEGNQDVTTKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKV9</accession>
    <name>A0A183HKV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IRK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS8122</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008942">
        <property type="protein sequence ID" value="VDO54105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKV9"/>
    <dbReference type="STRING" id="387005.A0A183HKV9"/>
    <dbReference type="WBParaSite" id="OFLC_0000812001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000812001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000812001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO54105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000812001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14065" checksum="4937A4C371F23B0D" modified="2016-09-07" version="1">MILAGIEPITVKHLIDDQSPLFAMTPDELHNADFELIMIVEGIVEATGMTFQARTSFLPNEILWGYRFRSMVILNEKIGKYEIQYKLFDEIESIDGINFKVMEIDDDNNDNYDSSRNHSGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL47</accession>
    <name>A0A183HL47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GT23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8210</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009107">
        <property type="protein sequence ID" value="VDO54574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL47"/>
    <dbReference type="STRING" id="387005.A0A183HL47"/>
    <dbReference type="WBParaSite" id="OFLC_0000820801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GT23" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO54574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11182" checksum="112B0B53E32E42AD" modified="2016-09-07" version="1">MKLIVFRYPNYEIYGDPKISNLAQVHSRYTTGSLIGIVIDIELLSRCMYLVCTFSSQVCRMGYELMQVRFGDAGDRFHSLDDIYYFGGQQVAVHQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL89</accession>
    <name>A0A183HL89_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS8247</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01009173">
        <property type="protein sequence ID" value="VDO54771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL89"/>
    <dbReference type="STRING" id="387005.A0A183HL89"/>
    <dbReference type="WBParaSite" id="OFLC_0000825001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000825001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000825001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO54771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000825001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8549" checksum="8E7C46CD8A20BC6F" modified="2016-09-07" version="1">MDCLDRTNVVQSMLAKESLKDQLCYMKIISNGFEVDSYPELSITFKRIWADNGDECSRQYAGTGALKVQWLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL98</accession>
    <name>A0A183HL98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAM-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8259</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009194">
        <property type="protein sequence ID" value="VDO54827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL98"/>
    <dbReference type="STRING" id="387005.A0A183HL98"/>
    <dbReference type="WBParaSite" id="OFLC_0000825901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000825901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000825901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000825901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17053" checksum="37656F547B64FF26" modified="2016-09-07" version="1">MNRVSESIEVIAETNENEPSTSGIAKDKLVRSYTYSSWKRLRDVCRALQETQEKAVLQRKKLDALLANEQEYRDLAERVKCEQVELQALRDCVERQKCRIMTCRMKLIHFNDEKFQKDMMANKRSNEVIKIQEDLLKRKTALSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM27</accession>
    <name>A0A183HM27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8539</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009746">
        <property type="protein sequence ID" value="VDO56168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM27"/>
    <dbReference type="STRING" id="387005.A0A183HM27"/>
    <dbReference type="WBParaSite" id="OFLC_0000853801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000853801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000853801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF23">
        <property type="entry name" value="RAB11 INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO56168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000853801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17242" checksum="C3D920B9BE52E046" modified="2016-09-07" version="1">MQPFPFPHYTKNFRQSFIVIAYVISARGLSLKGHNKLEVFANLTISGKGNWKSKVQTDVIRTTADCKWDQRCEFTLNDMDSVLTISVNHRTVLGTTDCIGAIELPLNSLIPKRMPTWYRLCKKGKYDENEQQTKYRGEICLKFEFSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNR8</accession>
    <name>A0A183HNR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9126</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010877">
        <property type="protein sequence ID" value="VDO58805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNR8"/>
    <dbReference type="STRING" id="387005.A0A183HNR8"/>
    <dbReference type="WBParaSite" id="OFLC_0000912901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000912901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000912901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF26">
        <property type="entry name" value="5' EXONUCLEASE APOLLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000912901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22652" checksum="F681689863BF2D6A" modified="2016-09-07" version="1">MYCSPITAKVLSVISSRKKQRGISKKWIRALDLNVWHKMDGFRVMLIDANYAPGAVMFIIEGEYRNVLGRILYTGFFRADARFYQDKKFDVICIDTTYVDFTRDSTGQKEFPSRRSSAKKAADLIPVLKRRGVENVAIPVPLIGHEGFLVNISRELNCKIWLHPERFEIAHILGISDYFSDTKEDTYIWTCSEMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNZ3</accession>
    <name>A0A183HNZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MyTH4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9205</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011052">
        <property type="protein sequence ID" value="VDO59171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNZ3"/>
    <dbReference type="STRING" id="387005.A0A183HNZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000920401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000920401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000920401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="1">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000920401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18929" checksum="D54235C12E36DC2E" modified="2016-09-07" version="1">METRNIRRLNLYAETSEGCENNTAIIAEHNRTTDLSSLADVQYIDLPKNVEKELENGLFANRMPDIRTVYHYIPYNKRIDKSLKLPAETIEQFAENNFKGHLLQMRREPIATPFLHKETEIEFNQSVEMFAMILRYMNNTQMSCEQLAILGKAIIQIYWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP34</accession>
    <name>A0A183HP34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9245</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011145">
        <property type="protein sequence ID" value="VDO59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP34"/>
    <dbReference type="STRING" id="387005.A0A183HP34"/>
    <dbReference type="WBParaSite" id="OFLC_0000924501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000924501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000924501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000924501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8984" checksum="854AE7D4A5803BA8" modified="2016-09-07" version="1">MFRGNSLATKAMEAYMKLVADKYLQNTLGEFVKVIQQSDKDCEVDPLKMANISVLSLEKNRHQLVANVKTVWSQILARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPI7</accession>
    <name>A0A183HPI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011471">
        <property type="protein sequence ID" value="VDO60281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPI7"/>
    <dbReference type="WBParaSite" id="OFLC_0000939801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000939801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000939801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000939801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9082" checksum="9F9151385853D513" modified="2016-09-07" version="1">MILNFFIDGQVFHIVTLVLPQLIDQVYPLQDNHRAIILHMVHMVLNINVPPTILLVEFHIHRKLSILISMEIIHQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQE6</accession>
    <name>A0A183HQE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MENTAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9706</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012202">
        <property type="protein sequence ID" value="VDO62651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQE6"/>
    <dbReference type="STRING" id="387005.A0A183HQE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000970701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000970701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000970701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="6">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO62651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000970701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14878" checksum="4456CE8899E91131" modified="2016-09-07" version="1">MSGAVELKSSTRNNEENQIRPYPKMSDTEEFFLSGESRISKDRRRFTVVTVFDVCLTALLWVISTVSKGSDWPVVFFREIDISQPDFMKLSLFDVVVSYFISFFSHFILKYKFQELFESFKYDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR94</accession>
    <name>A0A183HR94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10006</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012877">
        <property type="protein sequence ID" value="VDO65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR94"/>
    <dbReference type="STRING" id="387005.A0A183HR94"/>
    <dbReference type="WBParaSite" id="OFLC_0001000501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001000501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001000501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001000501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16998" checksum="DF439FA47702EE0C" modified="2016-09-07" version="1">IPNPFFDLAGITCGHFLVPFWKFFLATLIGKAIFKMHLQMFFVVLAFSENTVEHLLVHLKAIPVFGVRFHQKLMEYLAFQKIKLHKNGSSHIEVVFVSSFTELDSTMLQKCASFIVTSMIIWFLLSIINSLAQNWHKRLCNAKKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRC9</accession>
    <name>A0A183HRC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS10039</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012959">
        <property type="protein sequence ID" value="VDO65317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRC9"/>
    <dbReference type="STRING" id="387005.A0A183HRC9"/>
    <dbReference type="WBParaSite" id="OFLC_0001004001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001004001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001004001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000260">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO65317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001004001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21262" checksum="59CF4DC70F26102C" modified="2016-09-07" version="1">MQVILNLIPGDKPFKCEVCNRAFTTRGNLKVHMGTHMWQQSPSRRGRRIFEFGADNILRSEFLPAFGLGTEGALRIGPFDPKINPVHPGRFGLDLPPSQSLAVPPAPPAPPSPFSVLPFPLPLLPQVTNSGSCISNQMDTVMWMWKTVCSVCQKICASPQELEKHLKQHLNGTVRTDNTNTARITPLLQKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRL9</accession>
    <name>A0A183HRL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10131</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013206">
        <property type="protein sequence ID" value="VDO66096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRL9"/>
    <dbReference type="WBParaSite" id="OFLC_0001013001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001013001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001013001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001013001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6895" checksum="E2E0C4246E776271" modified="2016-09-07" version="1">MAFKLGDELMHMIGDFANMNRSPDFKVKTNNENPQKAPKPRTERIHSINLAVGVSVSKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRW9</accession>
    <name>A0A183HRW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HCO3_cotransp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10226</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013398">
        <property type="protein sequence ID" value="VDO66811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRW9"/>
    <dbReference type="STRING" id="387005.A0A183HRW9"/>
    <dbReference type="WBParaSite" id="OFLC_0001023001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001023001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001023001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001023001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15371" checksum="50BA5C6676E49FCC" modified="2016-09-07" version="1">MKSFMASMIASMLLLIFGHNSPYLIILFMFSDSILVHSISPLYQVLLADYIDEDMTYYSRPKPISTIIYGLVAVLVRPAQSFAPFIVVVILTQFGYKVTVKSFCFILFLILDIFIDNHKFNANASEIRFYSVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS22</accession>
    <name>A0A183HS22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10287</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013539">
        <property type="protein sequence ID" value="VDO67304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS22"/>
    <dbReference type="WBParaSite" id="OFLC_0001028301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001028301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001028301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001028301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5152" checksum="D6A9168EAFEE7ADD" modified="2016-09-07" version="1">MAMMLILIVSVRPLVHHPFSAIFDGIVFIRLVMITNMNLRRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT80</accession>
    <name>A0A183HT80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014533">
        <property type="protein sequence ID" value="VDO70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT80"/>
    <dbReference type="STRING" id="387005.A0A183HT80"/>
    <dbReference type="WBParaSite" id="OFLC_0001069201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001069201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001069201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001069201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9827" checksum="61CA42F0E0697B5B" modified="2016-09-07" version="1">MESAQHDGDASLLQINSTLGQDEDMEFRARSPQHVEMYTFRDAIDVNYQRMAVTGEELSGVCKDSNWLNVCILIEKNFKRMEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT91</accession>
    <name>A0A183HT91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1943 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10703</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014551">
        <property type="protein sequence ID" value="VDO70600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT91"/>
    <dbReference type="STRING" id="387005.A0A183HT91"/>
    <dbReference type="WBParaSite" id="OFLC_0001070301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001070301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001070301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Vitellinogen open beta-sheet" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO70600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001070301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19022" checksum="092744CF85405D40" modified="2016-09-07" version="1">MDTSILLVPNGYIPREVAFNFTVHLFGKSINILEIGARTENMEEAEEELFGPDGYISNPNGHVFREKRFQSRYPKLNHLKELHMRRNIGIESQMRASFYMRMFGDDLQYCGFQRDHRQFLDEVKESIELDRVLTKLMQEKTKKVKDRNCVALFFNFRSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTL1</accession>
    <name>A0A183HTL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10821</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT43 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014877">
        <property type="protein sequence ID" value="VDO71599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTL1"/>
    <dbReference type="WBParaSite" id="OFLC_0001082301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001082301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001082301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO71599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001082301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11707" checksum="601BFAD4EC1EE304" modified="2016-09-07" version="1">MFFIFVLHDVANAPNLNVNQISTTSQLDFTNSKNISLAKLDDIDLSLLSRFLCLEEEVNDEKISWTWDYLFANISTEMRDEWAQDEEHDDGDYEDKNLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTR1</accession>
    <name>A0A183HTR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10875</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015010">
        <property type="protein sequence ID" value="VDO72057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTR1"/>
    <dbReference type="STRING" id="387005.A0A183HTR1"/>
    <dbReference type="WBParaSite" id="OFLC_0001087301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001087301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001087301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001087301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19723" checksum="43D127E4142111D9" modified="2016-09-07" version="1">FLGTAFICLQNLVKTFKYGGRQFLLSGNEIEAITVIMGKTLKRQLYHLPGGHRKVINTRSVTVVEEIIQQLCQELNIRSAAEQQEFCLCYILESEDKLKMLANDEYVMDICTELEHNQKQYFLLLKRTVWIHPLRMDNALYIDVMFFQVLFTFSFTLINSNNLNYLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTS6</accession>
    <name>A0A183HTS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015050">
        <property type="protein sequence ID" value="VDO72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTS6"/>
    <dbReference type="STRING" id="387005.A0A183HTS6"/>
    <dbReference type="WBParaSite" id="OFLC_0001088801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001088801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001088801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001088801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20091" checksum="3A0C59AD1B23AF64" modified="2016-09-07" version="1">MFPTGVTKFVKIAAMSSELIALGDNGFFYSWSWKNDGHGSMTAHPFGIKLLTSAPDEEKFIDVVSCAYRACVITNMNRVASFMDGEACGIKISNMLLTPLMEIPDGEKYASLYVCPMGIYPFNERRKLWERMRSKSRRNSNLTSPEVVEGCEVRTKSHPIYTTGSVALNFSSGTPMVGVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTZ1</accession>
    <name>A0A183HTZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular sulfur oxidation protein DsrF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10953</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015219">
        <property type="protein sequence ID" value="VDO72654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTZ1"/>
    <dbReference type="STRING" id="387005.A0A183HTZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001095301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001095301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001095301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001095301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17405" checksum="926383AF660CAD36" modified="2016-09-07" version="1">MFGIYLTYALYFVQPESYVAQVRVTPDQMADLIDFVNERLIPERHIDAFAALFKLINGGAFRIYAFEKEHNPLLHRRFDLRELDEGGLDESETQEPNFLKALGDDVVLTQADIICKRYLAAKEKAKLPVDSGINLVQTTVSEIYNDSPILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUJ0</accession>
    <name>A0A183HUJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11157</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015753">
        <property type="protein sequence ID" value="VDO74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUJ0"/>
    <dbReference type="STRING" id="387005.A0A183HUJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001115201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001115201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001115201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001115201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16806" checksum="17A3D41C96E5217C" modified="2016-09-07" version="1">GIYIAEAAKRQAESYFQFEKCGQFWRIVNDRHHYGDSNLPSSILFPNLKRFSLVTVPQAINRLLQTISSANDTLLKNNASMGGRRKKRIDKLALMNGKKSTDKDDSGRSIMNNYLLYFRNQQMEKAYQVQFDQWFVPALAISIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUV4</accession>
    <name>A0A183HUV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11267</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016070">
        <property type="protein sequence ID" value="VDO75225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUV4"/>
    <dbReference type="STRING" id="387005.A0A183HUV4"/>
    <dbReference type="WBParaSite" id="OFLC_0001126601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001126601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001126601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF25">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001126601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18735" checksum="BD3DFE067E387A87" modified="2016-09-07" version="1">PSAFAFSLFFFSFFQDKAGIPPIYVTKWWFGCFLDRVPFPLALRLWDVFLLEGDVILIAMAYNIMKMHEKTMRKLQMENFMEYIQTVIAQDFGFSDEETMKSLQDCLKKLHSDRMLLPAPPKPGDIPETPVKPFGPVLSRSMVDIRLDIAEIQSRSSRANCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWF3</accession>
    <name>A0A183HWF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017571">
        <property type="protein sequence ID" value="VDO79453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWF3"/>
    <dbReference type="WBParaSite" id="OFLC_0001181501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001181501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001181501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001181501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7781" checksum="876AE1E9DA3BB192" modified="2016-09-07" version="1">MTSSETTEDRMGKTRVMASFFKKLGEKLRNYQRYQKPEQFSDLSSSRSYSLDLIKNKRILSSGVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXD2</accession>
    <name>A0A183HXD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12147</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018485">
        <property type="protein sequence ID" value="VDO82294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXD2"/>
    <dbReference type="WBParaSite" id="OFLC_0001214401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001214401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001214401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001214401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9060" checksum="A63FA5FB55B2CE61" modified="2016-09-07" version="1">MKTERICTTTNIEPKESDDNDNESQYRIVVVESENGDVKTYTELMNYSASFSDAAYENGDTLWSTDVYDLSTKEEIDVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXM9</accession>
    <name>A0A183HXM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PNP_UDP_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12246</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018772">
        <property type="protein sequence ID" value="VDO83176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXM9"/>
    <dbReference type="STRING" id="387005.A0A183HXM9"/>
    <dbReference type="WBParaSite" id="OFLC_0001224201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001224201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001224201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001224201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="5674" checksum="320DB2727A3DF3D4" modified="2016-09-07" version="1">MFHGIGIPSLSIVIVELIKLLYYAKAKDVLAIRMGTSGGVGAAPGTVVLTSAAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXY1</accession>
    <name>A0A183HXY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019073">
        <property type="protein sequence ID" value="VDO84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXY1"/>
    <dbReference type="WBParaSite" id="OFLC_0001234401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001234401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001234401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001234401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8893" checksum="7B2D6AEA345F667C" modified="2016-09-07" version="1">MVFNSIELGIASRYHCDWARSAIGVEKIRKITYYEQNVFKIKKREDNFKWTNKGRNICCQDNKHVYRPKYFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXY9</accession>
    <name>A0A183HXY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12353</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019099">
        <property type="protein sequence ID" value="VDO84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXY9"/>
    <dbReference type="STRING" id="387005.A0A183HXY9"/>
    <dbReference type="WBParaSite" id="OFLC_0001235201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001235201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001235201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001235201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16514" checksum="2DB570202EFB39FE" modified="2016-09-07" version="1">MKLFVLQNGTSHFQSSPRSSIMNPGQTDHASFVKDEIFDNQISLQPPSVATTSSTHLLTPSSTPTTQRKNRRISNLFQRPKDHGHDDKSHRSAAEISMGMGRAIPVKQGHLYKRSSKTLNKEWKKKYVCLHSNGRLSYHQTLKVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY41</accession>
    <name>A0A183HY41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12403</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039836">
        <property type="protein sequence ID" value="VDP11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY41"/>
    <dbReference type="WBParaSite" id="OFLC_0001240401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001240401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001240401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1373"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001240401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2174" mass="246599" checksum="4A2FC369676557B6" modified="2016-09-07" version="1">MVFESVVAEVLNRVLGNFVNNLDASQLNIGIWGGDVKLTNLEVKETALDDFDLPVKLKFGCLTKLVLKIPWNDLYRQPVIASIEGLNLIVVPNKGVVYNEEKAKKNEKEEKDKALTRLEENRKRRRKPPDLASDTFVEKFIATVIKNLQVTIRNIHIRYEDKYSHRSRPFVVGATLEGIDFKTTDENWNETIHKEVVKVVYKLVSLKNFAIYWNSDSKLISDSNDSAVISQTMNDDIVIGSRKPLGYKYMLEPINMQVKLALNQKPETDNSNWQIPKIKLILDLDTLTIAVGKFQYQDLLLLLEAQERFRTAAQYLKYRPHLNDYKDHYKEWWLFAYSAIIEEIVRRRRNNWNWKRMKKHRESMKAYKDAWLKKQTEKNLSSKDRSIIEETEEHLDVFNINIARQQADMEIDRRGLKRLEDQPQGWISWVGNWWSGGSDQKSKALPSSDIMTKFEEALTAEEKAKLFDAIDYQENTPPTDYPKHFVENVVIANLNLLMIVIEDALTLKFAIITTKIEHRASAQAINLKSGIKKVAINGCGQQVLFVQDDSIDWLTVLVETNPLNRDKVGYDQYIKVALAPTVMKYHAPAINTAIEALRPPESVRLNQLTAAAMARYEDVKARSLTGLAHVVDTRTKLVLDIRIAPLTIIISENGIFNEGKRNLIADLGLLTITTVEDDSFIETSLLSNKEAERRADLLNRAYDKFSVKLTDVQLIFSDSYQSGMNAKLEPKSNFHLLQPTGLNIAFHKSSIDDLQLPKIKIMGELPDIIITISDERLLELVKLILSIPTPAPEKEINALSTAFPPAERARIKDLAKMHAIMEANEISEVEEDLKVKKNDPQKQKQKKTDVQQIQLEVKLTLKQIEIVIGTSDGVFLSVQIKNLGCGLQMRTFDMVAVAYLGDLIIEQPQYKSLVPERNTLFVIDNIHNTDQNLLQFKYVQANKESPFFATDYNSMEQAIDISFKAMIVSLHQDALISLKKYFETLQIKIAELQNQGKPVQDQSDAKIPANDIAMFHEKKMLSRSSSQQSVSASELKLSHAKRERELAQTRNDIVIKVHVNAVFDALLVYIGSTKCLDTALSINVVKIAVTMRMRTMEMEGGIKTISMEDRTGTTIHKHLLALCGEDKEMLSFTFKQYNRTEAEKKHMQPSDLDFFIKGRFARIRFVLLFLWLERMKRFAVPFQAEAAQVAAQAQSYASEKASQAAQKIKHLMEESPLRIGLDIELAAPTILVPKNSMSLNALFVDFGKLTVVNSVSAAQHERKAIIDSMQINLTDMCFGISLFSEGSIDVLSTCQILKPITFSLLIYRNLSFEWYKTAPQMLVDAHLPRIEIGMTEEDYATILKTLSGNLAEGSESSSEPSPSINPSIRRKRSIDEKRQGSSEKAASESDEIPLSDSKAKSLVFSFKLDEIAALLYRGSSNLENSKGEIARETTAGFAAVRLKKIKLSGSRTENGELDVAVSLEVFIMDDERSEKTKIRRLFDKKPDSTGKINEEFIAARYQANTAGDKIITFSSSAFFLCLCPEFLGALMKFFAVKKTPEELAREIEKVNVSNITQNKEKVEAIPSAGTTTINCTMHKAEIILIEDAVNLENSQALILSFNVDLKTNLESEKQIMIGGIKNLQIISTYYLESKRDQTPYEILKRTDINVQLTTEQKAMSENFVVHIGQLYLKISPAIIRLLSAVSSNFLSAANEDSFTAQKHVLKKYPNYWEKRKINRNKHWWFNVLAEKQEDFEYAVDVSSTINREQRGTIIMESLMVTLEAGVENRTVPMVLLESSTMINASQWNALLAVDANVQFQISYYNETFCVWEPIVEPVEVSDNTWKSWNLKVELRTHGEDELSADGALPLPQRTIDVKASELLNITVTKSLILLSHNLMDSFERAAKLISPSMMRTFPGNSKYLILNNAGISTKVGNTETISADGQSVDATPCTFVDLSVPVDSNEKIGLTQSQITKKAELRLIFDEIDTERYVNIMRSESRTFELPMKNDDGKQWKIVVETKVENMRRLIYLHSIFVNHLDIPFEIHSMRDGRLDFCGIAETNGEPLDIALPLLYTATGELFIKPSQDDAYEMSNESICWNKFEDKARYIVRCDLSEDMKQGLFIALIVEEVPLKAERSRNLDDSSYVVHIFSPLTLHNFLPFPLKLISPIQKELSGGEEVSLNIIPGQNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ26</accession>
    <name>A0A183HZ26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039918">
        <property type="protein sequence ID" value="VDP12036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ26"/>
    <dbReference type="STRING" id="387005.A0A183HZ26"/>
    <dbReference type="WBParaSite" id="OFLC_0001273901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001273901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001273901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001273901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66218" checksum="0A67C517A0A029B1" modified="2016-09-07" version="1">MNFRRSSFFLLIIWLFWSYSVFQLAIEFANFFRHESGDGSGPFILKKVVIDDEGDAKESDNGIEDAVIGLSYQDHNYGRRSGNAQKNDGENGEKFPIIGGLASYIDRGTDRCRPLTINMLHLGDEVSKVPVGQHSRDANSGHYVRSHPYGTHNRKISEMDPRTPCRIYSAAVGGCRTNQTRRQVFANKENERFLSYFAILWLPVSTNEQIFSRQTSVTATQNYRAARRGMTQISANNQSDVLFRSRQFVGSGGAFGVSTPSNKRVLRPAHPPTPAVSTCRQSMRQVIPTNKSISTTMPAYAMAVNAAGADSETHSTDMSVGLAPFLVPSRRPRPVVRNRGYFFLYFIHIVSKLSGEYHMLSTIVQKDSAVHAENQSNALITTPRQHLKKNVALNSGVVKQQYIMAEPLEPCHVPCLQHTVQHAVSNAESMVNMMNEKLTSKNVQNSSAAAVHCKEEEQQSSLQNLSVDSREPVYVVNEDRIQNSEPTAQPCTAFPRRSHQDIARYVEEHYQKSRKVPQLSLQESFVANSRQLLTRQLDELQMLQPRICHSEVAAFDNSKRMKKVDQQSVTQPVISVSVNTPPKELLQVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ53</accession>
    <name>A0A183HZ53_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12765</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01039927">
        <property type="protein sequence ID" value="VDP12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ53"/>
    <dbReference type="STRING" id="387005.A0A183HZ53"/>
    <dbReference type="WBParaSite" id="OFLC_0001276601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001276601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001276601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001276601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25361" checksum="5638EACC0042C219" modified="2016-09-07" version="1">MNLSLFICRDSTCKHCRQCNKCISGFDHHCKWLNNCIGAKEEERVKARIIFAGTLQFTVQILFLLLVLSVSFISAITSICLIVIVAISFINIGLLSNTEKLPIKVMLWRGLCFAASVPYSIVAVLCAHLLYFHYKLCQSMEITLQNCLCNIINNRTFFILEKKFITRTIRASSMESSCAFHRKRGMTTYNFIRVNRKCKAIAKHNRDKKLYPARILSLFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0S7</accession>
    <name>A0A183I0S7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13339</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040152">
        <property type="protein sequence ID" value="VDP13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0S7"/>
    <dbReference type="STRING" id="387005.A0A183I0S7"/>
    <dbReference type="WBParaSite" id="OFLC_0001334001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001334001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001334001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="226"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="491"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001334001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="740" mass="83093" checksum="346B9A54370A86F0" modified="2016-09-07" version="1">MVIIQLDRPFSSPAILYYLFSVGGLSRFVDWYETLSYEPLMDRRKRSSNGLYAPLSLQFASHNRSFHLILHSLDDSTNVFSDNFIFDVDGKDEHVSMEDFLVHGHDKNDPESTLYGSFRDGIFDGHIIYSNGESYTVDKIDRYLHWKHRPKHFHSIIYSDSSINFWKQRKKRSAKETNQDCGLDHTIQQKMEIIQNGVIVEDEENMQSYRGGAFDERYIFESRSKRAANQTKIINGKEIYKVRTREEIASLFYNHIKAVNQIYESTSFGGINGITFVIQRISLYTPNTCKDGKPKGISQENPFCEENVDVSNYLNLNSRKNHSDFCLAYAFTFRDFVGGTLGLAWVASPNHNTAGGICQQYTKYSEASNFVYRSLNTGIITLVNYGNRVPNRVSQLTLAHEIGHNFGSPHDYPMECQPGLPDGNYIMFASATSGDKKNNAQFSNCSIANITLVLTEVLQQRPVDSEFDFRLGGFGNNMGAGKRNCFREAKSSFCGNQVKEPGEDCDCGYNAEDCQTMKDNCCNPRQSGPASRCKRIHSAQCSPSEGPCCDASSCQPYASRKTCRAESECLKQQQCNSTSPECPPSDPKENGLPCQDSTKVCNDGNCNGSVCAQVGLKDCFLTVGSPEHLCHLACEDENGKLFFVLVACRSTLTLPQFAVGKYKQSGRANKPGLILLPGSPCNNYKGYCDIFRKCRSVDADGPLARLKNVIFNPKTLYEVKYWIQVNWWAVVLGGLGLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I161</accession>
    <name>A0A183I161_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Clathrin adaptor complex small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13473</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040218">
        <property type="protein sequence ID" value="VDP13854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I161"/>
    <dbReference type="STRING" id="387005.A0A183I161"/>
    <dbReference type="WBParaSite" id="OFLC_0001347401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001347401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001347401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="194"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP13854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001347401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52036" checksum="B8000838C1A8FDE0" modified="2016-09-07" version="1">MDIADDRKSWLGSLFTALHSHYSESVMIGGLFVYNHKGEVLISRIYRDDVSRNAVDAFRVNVIHARQQVRSPVTNMARTSFFHIKRGNVWICAVTRQNVNAAMVFEFLNRFADTMQSYFGKLNEENVKNNFVLIYELLDEILDFGYPQNTDPGVLKTFITQQGVRTASKEEQAQITSQVTGQIGWRREGIKYRRNELFLDVIEYVNLLMSQQGQVLSAHVAGKVAMKSYLSGMPECKFGINDKLTIEGKGRAGSDDPTKSTRISVAIDDCQFHQCVKLTKFDTEHAISFIPPDGEYELMRYRTTKDIQLPFRVIPLVKVVVKSNFKPSLLAQKIEVRIPTPPNTSGVQLICMKGKAKYKAGENAIVWKIKRMGGLKESQISAEIDILSTGSAEKKKWNRPPVSMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGLYETRNSTKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3B5</accession>
    <name>A0A183I3B5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14227</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01040688">
        <property type="protein sequence ID" value="VDP16071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3B5"/>
    <dbReference type="STRING" id="387005.A0A183I3B5"/>
    <dbReference type="WBParaSite" id="OFLC_0001423501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001423501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001423501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP16071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001423501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21542" checksum="AC5690AF6EA8A668" modified="2016-09-07" version="1">MYTSFLHNLFKRGPTTRLQAMMLLNGSSHNIQISWESAINVELIAINIRGTFRSGRLFKTDKNRFLAQVRQHEFELERSHFTEEVVKMDEESDAKSAEQRQFIINMTKFAWSNYRKYAWGFNELKPLSHSGHSASIFGSGKLGATIVDALDTLYIMGLKEEYEEGRNWVEKFFDLKLSVSFCISIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3N3</accession>
    <name>A0A183I3N3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14344</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040782">
        <property type="protein sequence ID" value="VDP16641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3N3"/>
    <dbReference type="STRING" id="387005.A0A183I3N3"/>
    <dbReference type="WBParaSite" id="OFLC_0001435301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001435301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001435301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP16641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001435301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13372" checksum="FB7E618441D46A6B" modified="2016-09-07" version="1">MADPTVLKDIAIKTGVVKRLIKELCYYEKEEEKLMNKLQTMQAGGDVDEHILKKQVELLQETKQMIPECARRLTNSIENLKKVIGEHEALLQDTSEYIAAAEQIKVGTEECLKIKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Q4</accession>
    <name>A0A183I3Q4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Anion exchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14366</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040796">
        <property type="protein sequence ID" value="VDP16731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Q4"/>
    <dbReference type="STRING" id="387005.A0A183I3Q4"/>
    <dbReference type="WBParaSite" id="OFLC_0001437401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001437401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001437401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="158"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="349"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP16731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001437401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="708" mass="79660" checksum="64C5DBF868F33F31" modified="2016-09-07" version="1">MLELEKGDKGKRQWKQVARWIKYEQTIEGDGTRFSKPHITLLSVVGLMQLKNCLRKGVILLDVEAYSFNEIAGISFAITVKPLAELLFLCLKISLIFSDKICASWVERGLVEAENSATVKDLLLCPKYHLIGKNMLPSTEIKNDVKAAVKILPTDDIENDLQDENILDLTSKEMKKLAEGTEGAAVMAGIFNGIDKPVCAFLRLDKARVLFPELPNVSIPLRFVFVLLNPHDHYENETRGIGRAVGALLSDEIFKKVALCSLEPYTIADALEEFFAQVVVIPPGNCTIETRWEPNANTDQKFDMCNYIFKFWINRSVGMFYASYDDPFDEESILDGKKDTHNDIVRSGRLFGGLCNDIKRKAPYFVSDFTDFFYGRLSQSFAAAIFLFFANITSIITFGAVMERALHHQAVIENILCGGISGVIFALFSGQPLNILSATGPTLVFETILFDFCSRHGWEFLPFRFWVSAWIGVVLLVLVATDMSALVSLITRFTEEAFAALISIVFIIQSFQKLIEIGRDAPIIINPKRVFDSPCVCYLNEPMVLLNNISTRPKIMDIDPAECSRRGGEAFGLQCHFKPDVYMLSILLTFGTFALASGLNLFRRTYFLNSMIRNSISDFGVLIAIVVMTAVSQFIGLDLPVLNIPANFRPTMDRPWLINPLLVDWYVALLAVIPAIFYAILIVMDQQITAVIINRKDNKLRVWLFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I481</accession>
    <name>A0A183I481_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator complex subunit 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14543</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040943">
        <property type="protein sequence ID" value="VDP17539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I481"/>
    <dbReference type="STRING" id="387005.A0A183I481"/>
    <dbReference type="WBParaSite" id="OFLC_0001455101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001455101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001455101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001455101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38750" checksum="7E0168A48CDB1B72" modified="2016-09-07" version="1">MNYVDQQQFIMQQGQRMQNPRMISVPTTMTPQQLHRQQRTISDALSRLPPEVQQMAQQQINAETNAEKKRQVALGFIQGRVRLTQQYPGQGTMNTGGMMISVGLNQQVGMSQGNTQMVRMGTVQGGPVPYPPQNVSLQTGVGQMGPTQVSVQRMPNHYMASGMNAPQNIQYQSQDLGNVQNYNSQQQVTLTQPSSVGSAVQQTSSLHHKGPSSVPSAIYTQHHPENSAPAHSTAASEGDKSSDEPLYSQKLELLKPYHEHIKRLLERNRLDGQAPKSKFERLLEIMENRRKVELKLLEKLVVSVRNLIERDSLCFPLIDALRLESAESTKTSLPDPWGDFHQYAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4T9</accession>
    <name>A0A183I4T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14751</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041160">
        <property type="protein sequence ID" value="VDP18594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4T9"/>
    <dbReference type="WBParaSite" id="OFLC_0001476201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001476201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001476201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001476201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8093" checksum="BA69AD92A513FDDF" modified="2016-09-07" version="1">MGGDEIADFRPGEVHGGFATNVCSDEIASGEKDQYYGLIRDVIALHQVGFVHRDVKRGNMVIGINERDCRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4W4</accession>
    <name>A0A183I4W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14776</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041182">
        <property type="protein sequence ID" value="VDP18709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4W4"/>
    <dbReference type="STRING" id="387005.A0A183I4W4"/>
    <dbReference type="WBParaSite" id="OFLC_0001478701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001478701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001478701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP18709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001478701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46470" checksum="401983A89427CC2B" modified="2016-09-07" version="1">MIEFMNKKKENCELVPQFILEDAAERQQGVRIFCTQPRRLPVLAVSARVAKERNEKLGSTVGYHIRLEQKTSEQTVLTYCTSGVLLRLLTNDTNASNISHIILDEIHEREQKTDYLLIALRQALKNRDDLRIVLMSATMEESRELFKRYFGPGNVFCLDIPSTLHKVEMFYLPEILALTDYKHTSSFTGGTFFGKTARSLNDDQTYNRYNGDEMNSCYEIMPSRRIASSASTSSQVSPAVINQFNNRQLCPQISSNPSQEKGYYANCSGIIMQLESTIYDGYQIYSSPSGLTGFNCSQPPPNYVYAQQVPMTSYGMMAPYIGAPQMMYATYHVVPAQNDCQNYYVMPSNVQDYTQPPKFYISANNMNGFGTQWNSNGSSFSNQGSSFSLANVHTGHRDAVCLKYFHAWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Z5</accession>
    <name>A0A183I4Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14807</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041226">
        <property type="protein sequence ID" value="VDP18907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Z5"/>
    <dbReference type="STRING" id="387005.A0A183I4Z5"/>
    <dbReference type="WBParaSite" id="OFLC_0001481801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001481801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001481801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP18907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001481801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36381" checksum="27EA2535712E6D63" modified="2016-09-07" version="1">MLIGKPPFEADTLEKTYVKIALCDYSFPPKPKICISAEDLISKTQESYSVKKKENNIFQLSKAANFYQGFGESYSIGDSGIGSEGGLNTRPRSICDCRILYKQLLLGYYTVSHEASRPLDFQLNMVSKWVDYTNKYGFGCVLSDGTHCTLFSEKEAGRYLMISDTDQDPWTFLEWTTLDTISDQRLAKKIHVVELFSNYMDKELQPVYEYSTVRQQLDALVYQKRRSGVLLMFLALGTIQINFLDSHEKLVISRDEYGRLLLTVIDQCIGFHMYQLLPCASTPIRPNCQKVQQLLEKACQLLEGEEALLPRTYYATQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6K1</accession>
    <name>A0A183I6K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15362</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042014">
        <property type="protein sequence ID" value="VDP21518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6K1"/>
    <dbReference type="WBParaSite" id="OFLC_0001537401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001537401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001537401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001537401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12630" checksum="DFB8B17DC68EEAD8" modified="2016-09-07" version="1">MIPRRKQYFGICMLKMKYVALIFIHKVNSLPLVLRVENGLYIVIRIGRKFIRLRRERTMRLQPCDFQQLAIFWLSQPKEKNYQFMPYRVIFDTMLKYQRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6S6</accession>
    <name>A0A183I6S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15438</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042146">
        <property type="protein sequence ID" value="VDP21888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6S6"/>
    <dbReference type="STRING" id="387005.A0A183I6S6"/>
    <dbReference type="WBParaSite" id="OFLC_0001544901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001544901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001544901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP21888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001544901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17536" checksum="C84BF3A6C45D2D43" modified="2016-09-07" version="1">MQTEHKSPRSVEIRIPSKGEIVLVNETNAPRGTWKSAKIKELNTSADGRIRSVQIELPHGKILNHPINMLYPMEINQNEISTIPIQDSVEKIEEEEPIARRTRSVTRKQQIQELKDDDKQKPSIAKRFENITTQQQIAKRKNKPNTLLKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7U2</accession>
    <name>A0A183I7U2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15804</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042916">
        <property type="protein sequence ID" value="VDP23972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I7U2"/>
    <dbReference type="WBParaSite" id="OFLC_0001581701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001581701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001581701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000553">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="56"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP23972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001581701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22020" checksum="EC7F7DEC7CE4E378" modified="2016-09-07" version="1">MAYVQQILDVKFNLDNTPYKSIENIGTGAXXXXXXXXXXXXXXXXXXXXXXXXTPYKSIENIGTGAYGVVCKAHDQQSGQKVAIKKITRAFSVAILLKRSLREIRILRCLRHENIISVHDVFANTGSQGLDVYMVLDLMETDLHQIIHSRQDLTNQHYQYFLYQILRGLKVNFYNLLSLSIISIFCIRYYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UCM9</accession>
    <name>A0A3P7UCM9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">High-affinity choline transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2196</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001211">
        <property type="protein sequence ID" value="VDO32196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UCM9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000025">
        <property type="entry name" value="High-affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO32196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="59962" checksum="18764C9644657B51" modified="2019-02-13" version="1">MISFSATWVGGAYINGTAEALYNGGLLGCQAPFGYALSLVIGGILFAKKMREEGYITMLDPFQMKYGQRVGGLLFIPALLGEVFWTAAILSALGATLSVILAIDMTLSVIISAIIAVFYTFTGGLYAVAYTDVVQLFCIFVGLWVCVPASLLQDKTKDISRNAADWIGTIGGFKETTLWIDCMLLLIFGGIPWQAGKQKAKLHNFKVYFQRVLSSKSSSGAQNLSFVAGIGCILMAIPPALIGAIARNTDWRLTDYNPWNNGTKSESIPPEQTNMVVPLVFQYLTPKWVAFIGLGAVSAAVMSSADSSVLSAASMFAHNIWKLAIRPNAYEEEVICVMRIAIIAVGFSATLMALTINSIYGLWYLCADLVYVILFPQLVCVVYFKHSNTYGSITGYVVGLLLRLSGGEPLLSFPAFIHYPMYEEVIKEDGTALGTQFFPFRTMAMLGSFIACIGISYLSEYLFTNGILPIGMDFLKCVVNIPPERIALHSDVSFNISSETLNAQKPKDFEENYVKRNYLKPSDASTITELSTLQPSNNKDYLTLSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VZD8</accession>
    <name>A0A3P7VZD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002294">
        <property type="protein sequence ID" value="VDO36503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VZD8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="475" mass="54671" checksum="A7948800E33BAABD" modified="2019-02-13" version="1">MKLFDFSCYLSDNEADSSDLSDENTVDSEEDNRSSSSLMDRLLDDVAANCSGIFDYSEDSKSDEHNKISIDDNDDGDRDDKDEDELIRRYRKPRKRRLLFTPDDSDEDKENEEKDALKSIKNVHNLEADDRNDIETGIVSNQKKTNSADDVNALINESDEFNVNNQDSFLFSDEDDGRERNVIEPIDEANDENEQVEGMEEADSSDDELKIFRKLERTQKAKKKLILKSEYIDEEASLSGDDVGSDENDDEDQLDVYEAEEGDNDELPDDETIREQLHKQWLKQQQDEEDRKLLYWKDQLLIDGDLTEETDRTFRFKLRVTENENANEKMDDVAVDAENEVDDDEICKRRREISKWKIETKKVELHGESTLLKKTNPLLKAASKIIDKGNLNGNSQSDEQADTLVCKNSLLYHRKSLSQVLNQTKITLYTKCAETSSAHANGHIKRPLPSQEARRCVDVCLAPHYNDFLSFCLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W5C0</accession>
    <name>A0A3P7W5C0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SNARE domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002846">
        <property type="protein sequence ID" value="VDO38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W5C0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22310" checksum="D425762321D31239" modified="2019-02-13" version="1">MTQQLGNENSVETISLKSDISSVPDSVLSDSIIFGKDGLRKRKNQKADIMDNGIKNSEQDGWSDVQVPDFQEIEKTDDLDLLNNLDDDERTQLMIENERLYSQSLQVDSDIQKVEKQMAELYQLQETFAEKVSEQERDINFVNETTLLTVENIRIGNEQIRQAIQNMASRRVILLFCIIVLTFTLLFLDWYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WKW6</accession>
    <name>A0A3P7WKW6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011834">
        <property type="protein sequence ID" value="VDO61406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WKW6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19639" checksum="FE2472CAA6762337" modified="2019-02-13" version="1">MEEVQQEITDLGNTHAEYEETVPSDDISENQDSEFAQKVENELDSVYMRGEAGLRQFRQSGEIASLEERTRSKAQSSNSVNIKKINITGFEGQYAELPKKNHSLTYPSDLVIYSFPKGDLSDYPPPPKDEVGTPGWWLLDGGSVAPVLALGLTEESNILDMCAAPGGKSLLIVQSNLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XBT7</accession>
    <name>A0A3P7XBT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000271">
        <property type="protein sequence ID" value="VDO26842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZR6"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="168" mass="19657" checksum="980B5BB02678E050" modified="2026-01-28" version="1">MEHDWVHCVDRLLKAWTGYQLAVRMLSGGPETYQKAGWFAEVLAEHVFNSQNLQVHNLSEWISDILDHEFDLLLEDNSIEWLASSLLKCKLWLRNCQKAELEDFLSQLPSENAVQTAATESQVILDNSEEENIDFEEFEHETQDEQTKKSSKRRMKTDEDGWTTVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XG23</accession>
    <name>A0A3P7XG23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000031">
        <property type="protein sequence ID" value="VDO24655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871823at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="274" mass="32535" checksum="07EE8ABDD8A1998E" modified="2026-01-28" version="1">MWFIWIIVVNLHFNKINAQFNNQIWQYRSPAKYQIMEKPTFFSNHEQSHLRIPIPVYEFKPNLYPISFPVSVYPSLSPQAFTVPTPSLQNLPFQSTWMTNNPPQFTNQKEYIGYVTEIKKSDDVINRISTKPENDYDISIQLRNNLPDFLCGTSDDVQKKFYKIVLNPDESFQQKQSKLDQLVSTLDKKNQELYDRYRQMKELEERKKRDRVHAIVASMSNKAQTVFAKLSAVLMNPKMKDMDRMNKINDFYKNVDDDVKKEFKDRINDLNLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XPB3</accession>
    <name>A0A3P7XPB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011880">
        <property type="protein sequence ID" value="VDO61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XPB3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="200" mass="22452" checksum="B85BF5A946190145" modified="2019-02-13" version="1">MVDFLKQVWGAAAGQVFYSLLCCTGGLVTLASYNRFHNNILKDAWILCIVDIVTSLFCGALASSALGFLCYELELPLERFSFKGGAQLIFVYLPEAIAKLPVAPIYSILYFAMINVMVETVVSSICDEFPEVLRRNHRRILSAACIIFFALGMPFCFAAGFYWLLLLDYFTTTWTLVLLAFLECMAISWAYGSSFSFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z8K0</accession>
    <name>A0A3P7Z8K0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS6115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01005632">
        <property type="protein sequence ID" value="VDO45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z8K0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08003">
        <property type="entry name" value="WGR_PARP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WGR" evidence="15">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="357" mass="41071" checksum="27249A200E57DCD9" modified="2019-02-13" version="1">MQTKKKEDSKIDISGNDDNDEEEINKPERTSNSESQKSNDSDSITNKDMKKVILKGIAAVDPECRELIDTAHVYTESGDVYDALLNQTSAQHNNNKYFIMQLLESDGSKQYWVWFHWGRVGYKGQTSLNSCETDLMLAKKLFCDKFLDKTKNRWAERTNFEKVAGKYDYLPTDYSKIIEEKKNDNDIDDKKEVESKLDPDLQHLLTLICNIRAMEETMTELEYDATKAPLGKVTDEQIKAGYAALGKIEQHIKKKDFSSSFVEAVNNYYTKIPHFFGMRQPPMIKTIKQLKTEIKLLEALSEIGVAIRTFKKKGDVNIHPIDRHYMNMKCEISIVCADDPKYKNGFSIDIENGPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A1X4</accession>
    <name>A0A3P8A1X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009629">
        <property type="protein sequence ID" value="VDO55855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HLW5"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="162" mass="18414" checksum="6EFD790222AC2705" modified="2026-01-28" version="1">MLTIALLASAYLGICQETLYKVYGKHTEEAMFIIHGASLPLFAFMGEDIYKSVIAFSRSYPIDILGFRVPHMWAYLAATCLLQWMCISFIYRLNATFESLTVTMVVTVRKFLSLLISILWFRNSFTLAHWIGAALVFTGTLAFADIWTNPNGTAKETKEKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A5E5</accession>
    <name>A0A3P8A5E5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">60S ribosomal export protein NMD3 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010048">
        <property type="protein sequence ID" value="VDO56935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8A5E5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="157" mass="18436" checksum="40BEA7BB6503AC58" modified="2019-02-13" version="1">MQIGQDNQEVCTRSHLGHLLKPGDLVLGYDLRNSNVNSTLLDKMKTDRIPDIVLVRKVYDRSIRRERRNWKLKRLVQNDGDIYDSSSIGNEFEAWFFNFLEDLEEDEQMRQKINIYRDNTKQQAVCSDDITSDFPRGPSLHEMLDDLDLNADVEMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ERA8</accession>
    <name>A0A3P8ERA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039877">
        <property type="protein sequence ID" value="VDP11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278121at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="163" mass="18939" checksum="513B7813A22E3A61" modified="2026-01-28" version="1">MKIVFYLVIFTSTMAFKCFQCNNGVDEDDTKPCFDQETKCPKNAESCSTILYVAQQNDKMHMRKFCTTPDTSVSQYLRLFPSSVMCQNIFMNQEHVQHMTLMERRRREELPPAPPRQYKNNLLCISATSLCNGSIHREVIDRIMLNSTRHNVDIDSSLQDLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY73</accession>
    <name>A0A183GY73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000046">
        <property type="protein sequence ID" value="VDO24869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY73"/>
    <dbReference type="WBParaSite" id="OFLC_0000018201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000018201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000018201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000018201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8207" checksum="6C3A2C3D30542D56" modified="2016-09-07" version="1">MNGVSLHITLSFAREANGPKPRRFAIDDNLLCGDDTAYRNDFITVKIFRFNPSIFRYNLSHSRGSATSNRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYL0</accession>
    <name>A0A183GYL0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS320</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000095">
        <property type="protein sequence ID" value="VDO25381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYL0"/>
    <dbReference type="STRING" id="387005.A0A183GYL0"/>
    <dbReference type="WBParaSite" id="OFLC_0000031901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000031901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000031901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000031901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20401" checksum="D89BB8EA6D565123" modified="2016-09-07" version="1">MVGKCGAGISFWTRSGIGPFQPLKPMIMGHECSGIVSDLGPDVKRFAICRYNYVDVDDTIYAMKWNFLHFHCRWRYAKFFTVGAGYCFKLIQNNMSMEEASFLELLSSGLHVCRKANIGIGSHVLVLCADETVIVKDLSTQETARIIVEKLGEAADVVVECCGAQCSIKFAVKAVKDGGKIMLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYV9</accession>
    <name>A0A183GYV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorein_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS419</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000134">
        <property type="protein sequence ID" value="VDO25724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYV9"/>
    <dbReference type="STRING" id="387005.A0A183GYV9"/>
    <dbReference type="WBParaSite" id="OFLC_0000041801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000041801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000041801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000041801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="782" mass="88991" checksum="AC8A89573164A20F" modified="2016-09-07" version="1">MASIIKNQIIKHLSKFSKKYVDEMVCHFHPNFRFVRNITADQISVQILSGKGELKNIELNETVLSEVLELPTWLRVKRAICNRIAVKVPWTKLKSQPVQLFIDEVRIEVELSSEEVVGCESNPLSAFGDSTYGFANRVAEGMSLYVSSVEINFDSGVFRGSLTLSRLAVESKSPSWQPASDLRYTRIIDTASNRLLMFKMVTWQLLRIEASAQAKLSGNVINAPLRLITSSGKSRVCVKKSIIGTSLLKFSSLDGSVLGGRIQVILDNILWIATLPQVRSAIAFYDHIINIIKAAPKKVSTLQTQRIDLKFLPMRKSPSSIPVSNIFRSFDFERTSYHVYVGKIDLHLCDDNQTSDDYPEDWDIICGALQVTLLRLSIDFYPINNAISDRSDWIRYDDANHCAAWDHKILQFHLRKLCTELDDSEQDRIVDMWPKLMSQNFVIRMYDIIVQCVTDMNSKKEALFNLFMSDRKSSTAVRSDIPLFHLEFASFYHPTSENFPVPSNITHLLLGPFFLVIDQRTIRWLLFVIDDIKYALQISNAMPEVTKIPKTSLRINLLMPKIIVPLREPFISDIRFARRIVISMSTLLATNCEAISGDESCSFFKPISSNIIDFIDRIDLLVSKEKLKEFIFQLNQNSYEDIDQGERIWITTSPIWINTDFGEGTSSTPLLADTAFHALLSLKSMKVSVALQPMWKIRVVVNHFQFLQIMRLISSISVFMNQLIRDQKFFSSTRSNGSGTAVEVVCFLEEAELNILLPNQPIPTPYDLQEIMLQSSTISSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYX5</accession>
    <name>A0A183GYX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS435</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000141">
        <property type="protein sequence ID" value="VDO25783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYX5"/>
    <dbReference type="STRING" id="387005.A0A183GYX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000043401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000043401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000043401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000043401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39613" checksum="326DFAA2AAF38502" modified="2016-09-07" version="1">MSSPDLRVFGALFSQTASKPTWKSAKYCLNQKASCFDISPDGSSFLIGQANGQLVALCISDGELTVSDSCERHQSKITDVAFNPTADLIATCSSENKIELSSFRTDLSKSGNRRISMSMNEPVRALTFMEDLASHSNILFSGMGRQICMIDCSSGASFRILKGHKGVVTGFCTWGGCLLASSSTDKTIRIWDARVTEAVKVFDPLIKPGGLFSNAFFNRQVAGAFHVDGSGRILVRGDGSGQVHLYDTLSTKKIITKRISMRPISCLRIADPQRFMAIADEKKISLCDLRDIFQIPEPSCVTKCTRKCVALKFVILFGTFNVSEILKGWHPMKPSFAMLDNESALNLWQLEYKKSCTMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ04</accession>
    <name>A0A183GZ04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS464</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000153">
        <property type="protein sequence ID" value="VDO25888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ04"/>
    <dbReference type="STRING" id="387005.A0A183GZ04"/>
    <dbReference type="WBParaSite" id="OFLC_0000046301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000046301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000046301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="206"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000046301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45678" checksum="DFF2534479EEA7F5" modified="2016-09-07" version="1">MDEAKNMALLFFMDHLMQKNGRRTIHDLSCQFGARGFTAEMRDAVGTTQEGLTDFLTQHPSLFTVEGDQVCLNGFGDMTVKNNPLLQATANARNRDYVKEAVQFFEAKLQKFGPELQECLVYYTIFSLMQKRSIKSLLGHRSQAAPEVRLVSGRHLKDFCEFLQSQNDHFVVEGDRVRLKNMPEPSNAGIELDDEGKPLAGVKAKQAAVEYLKSIVEQNDEQPIPMDVFYQKFCDRFSHTVRQEVATNPKELLQFLKLNRNVFFIRSNKVSLVKNRASEDGSESGSTESSEFENNSSHLSHNAINRINLVKALKPAQESVLSINAEIDSMEERVVGVDFKTVILGVQGEEFLSLVILATTTQIVVFDVVHSDTILLESGVKEILESEKIIKVCLIVFSITFMVISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZP6</accession>
    <name>A0A183GZP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS709</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000261">
        <property type="protein sequence ID" value="VDO26780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZP6"/>
    <dbReference type="STRING" id="387005.A0A183GZP6"/>
    <dbReference type="WBParaSite" id="OFLC_0000070501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000070501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000070501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08688">
        <property type="entry name" value="C2_KIAA0528-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037785">
        <property type="entry name" value="C2_C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000070501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="716" mass="80103" checksum="BC968A15DD908A85" modified="2016-09-07" version="1">MLVPCTTNNLPAKLSVRVIAARGLPVMDKSNVTTDAFVEVHFDNEVYKTDVCSKSLSPVWNSDVFVFETDEQQLFDNSIQFRVMDYDTYSANDAIGRVFYDANLLVSKIRCSKVDSNSMEFTNWLPIYDSVYGIRGEIQIFISLKLLLSSDYEYVRIISASTISSSLIDDIIGLVSDISTVTDPEYEWIDRIRSPRASNEARQSIIRKSLRELARNIAQKAHSLGSNAVLGYHEFVDIESDATELITFRAFGTAVRLSQTDGKAAADERIMQHVLPKIYNYKCGAVVCTRSAQMLTNDSDAVTTRKKWWDDLKTELIRQALNLHCNLIIGYTEQISIRKKMALLSCTGTAVSVILTGTEHIPNCTIFHAACFTGYALPNENLNLCSCCKSSDAVCPDIILSSCSLPASDYLYGTVRPLQIYVKREVNSSESDDQLAYTIIQSLPFLEHELYNELMGEIRSGNTKYNAIFDFKSVVVIQEGALFAIVMGALCTLKALLKTDGSHILNRPDSFHQNDDMRSTSRVGLLDAARILRVSKFSDKVVLHLQPLHIRVDTDDSTKRPPQSNYKKMIKCFRKKVVDRERLAKMISEREISLQLGAFDDMKSTTSPASYAGIRVNNSSRFNISAKSAKSSNIPQRYAGVLIREVTRTMEDIADLDTFLDEALRDLVNLATSHVETVGATSFSIFEVPSVSLSISRDQASILLFITTDFDYPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1C1</accession>
    <name>A0A183H1C1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS1281</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="UZAJ01000580">
        <property type="protein sequence ID" value="VDO28962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1C1"/>
    <dbReference type="STRING" id="387005.A0A183H1C1"/>
    <dbReference type="WBParaSite" id="OFLC_0000128001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000128001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000128001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="441"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO28962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000128001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65847" checksum="6EC6AC1A592C3C05" modified="2016-09-07" version="1">MICSMIRYFIPRYKAGVLLNIIFIMMLILFIAFYTHNPLWFQLPTRKRERNVMVHEVPDYSKKRTGPGEDGSGVYLTGKQKIQGKADMKKWFMNLVASDMISLDRSLPDHRHEQCREISYPDNLPVASVVIIFTDEAWSPLLRTVHSVINRTPFKFLQEIILVDDFSQRDELKDRLEEYIKRFGNKVHLIRARKRLGLIRAKLLGAKEAIGDVLVFLDSHCEVSKGWLEPLLARIKDNRSAVLCPIIDHISAETLAYSGNDRVTDVGGFWWSLHFRWDPVPKEYRDIDPTKPIRSPTMAGGLLAIDRLYFFEIGGYDPKMDIWGGENLEISFRVWMCGGSIEFIPCSHVGHIFRAGHPYNMTGPGNNKDVHGTNSKRLAEVWMDDYKRFYYIHRSDLKEKDVGDLSERKALREKLKCRSFKWYLENIAKNKFVLDENVVAFGALRNPSSGLCLDTLQRDEKMAISLGVFSCQSGKSEAQLFSLTNDGKLRRELTCAKINRNAIVDNKAIVQLADCREDEKDDKWILKDGKLQNEDVDLCLDVMGLKNNDNIVARSCINDLDTQKWEILKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1D0</accession>
    <name>A0A183H1D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-complex protein 1 subunit zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1290</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000584">
        <property type="protein sequence ID" value="VDO28989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1D0"/>
    <dbReference type="STRING" id="387005.A0A183H1D0"/>
    <dbReference type="WBParaSite" id="OFLC_0000128901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000128901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000128901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000128901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47413" checksum="4BCE9D9400346EF2" modified="2016-09-07" version="1">MASIRCLNPKAELARHAAALELNVSGAKGLMEVMRTNLGPKGTMKMLVSGSGDIKLTKDGNVLLHEMQIQHPTAAMIAKATTAQDDVTGDGTTSTVLFIGELLKQADLYVSEGVHPRLITEGFEYASKKTLEFLENFKQTPKIDRELLIEVARTSLRTKLSQKLADHITECVVDAVLAIRIGNDPHPNLHMIEMQEMQHESDMDTTLVRGLVLDHGARHPDMPKNLKNAYILTCNVSLEYEKTEVNSGFFYKSAAEREKLVIAEREFIMRKVQKIVDLKKKVCDEAEKADGKKRGFVVINQKGIDPPSLDVLAKNGILALRRAKRRNMERLQLAVGGEAVNAVDDLTPDVLGHAGTVYEHVLGEDKYTFIEDCKDPKSVTILLKGPNKHTITQIKDALHDGIRAVFNTFSDRMYLYRYSITFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1M0</accession>
    <name>A0A183H1M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1382</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000637">
        <property type="protein sequence ID" value="VDO29331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1M0"/>
    <dbReference type="STRING" id="387005.A0A183H1M0"/>
    <dbReference type="WBParaSite" id="OFLC_0000137901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000137901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000137901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552334" evidence="2">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="301"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO29331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000137901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51077" checksum="B6C211A9AC2CF367" modified="2016-09-07" version="1">MTMSSIQYFWLILLLRTVKYSKPCVDVVFVLDGSASVKQHFQQMINMAGNMAKQFDIDKRGHRIAILEFSSKAIFSKWLRYPFDQFKVISVQSFIFYCNHMKYFPSEYHMKCYRDSEEVQQNVANLVDKPNVQLFVATASKPYNVQGLLVLVGNDSSHIVTNASFLNISRKILKPYSECLDSRTDFIRKKITSLPTATNNTFSTLSFATAATKHRINRLSGTLSEFVFRQVRFASTLPIKPVDAAAQSLVSTMTTKSILTKLNIKPGYSMIISQWPRYIILARNEHLRYFISVKLITSEGAIKDLHQAPSNGGTIRTGEAICYAVHEFNEKFGARKGARKMMVIFTNGYSQISTSFTIFISIFHLLYASCLVSVFRESWNLILKGEIEDNPIKASQLAHSKGIELKALSVADENVPPDTEQIISITGNPSVCIIFKLLNYIKLVVLNNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H314</accession>
    <name>A0A183H314_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1872</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000976">
        <property type="protein sequence ID" value="VDO31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H314"/>
    <dbReference type="WBParaSite" id="OFLC_0000187301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000187301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000187301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000187301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12268" checksum="283B177025D3E5E0" modified="2016-09-07" version="1">MPLPFRVPVAQVISRLAQHFRHLEQAGSPPVMFPSAFSHQQLVAATVELSCSAMKSASVSSNFDSSPRVYQETGNLCLIQKCVLCGSECCYSMSAKKESPDTIDCCCNSKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3F5</accession>
    <name>A0A183H3F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001081">
        <property type="protein sequence ID" value="VDO31583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3F5"/>
    <dbReference type="WBParaSite" id="OFLC_0000201401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000201401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000201401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000201401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9104" checksum="308854165581D9AD" modified="2016-09-07" version="1">MISLSRILHNGYFTKFRKLTKAGESDILSSRDNLPKHFNIFHSIVSSTQQALRTTFETDLYRNDWGFFDISLCSHTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H431</accession>
    <name>A0A183H431_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2241</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01001246">
        <property type="protein sequence ID" value="VDO32336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H431"/>
    <dbReference type="STRING" id="387005.A0A183H431"/>
    <dbReference type="WBParaSite" id="OFLC_0000224001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000224001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000224001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO32336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000224001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36767" checksum="5B6E9E267D2C7DEB" modified="2016-09-07" version="1">MENKVNLKCSKRNPHGRHAPQYFKEGQIIDCKFRVDKLIGGGGFGQIYRVIDERTKSILAIKIEPESHEPGRMILEQKVMLKLRGTPHIPQFYASGNFCGYNFIAMQILGKNLSELRKCQPKRRLSVPTVSRVGMQLVTALKAVHDIGYIHRDVKPSNICIGLYSHKRTIYIVDFGMARQYRFDDGMVRKERYYAGFRGTMRYVSVTVHERRDQGPVDDFWSLFYSLIELVQGSLPWSAFVEPNEIAKFKKNIIFDEFGRLVPKEMEKIMKHLSQLHYHQIPDYELLIAEFNKMLPKDMPEDLQYDWETIQNDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H559</accession>
    <name>A0A183H559_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2619</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001541">
        <property type="protein sequence ID" value="VDO33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H559"/>
    <dbReference type="STRING" id="387005.A0A183H559"/>
    <dbReference type="WBParaSite" id="OFLC_0000261801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000261801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000261801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000261801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14342" checksum="D77DC2921C508622" modified="2016-09-07" version="1">MQHIDFRSAFFFFSHDKRPEVQQQHPEWKVGQVAQELGRFWKALGEEERAVYERKALEDKERYAEEMRNYKGTPVQTITPMKMPMMATVEGVPTTGMMQMGVPPQHAQQMVQPQEVNDEGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H581</accession>
    <name>A0A183H581_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2641</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001555">
        <property type="protein sequence ID" value="VDO33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H581"/>
    <dbReference type="STRING" id="387005.A0A183H581"/>
    <dbReference type="WBParaSite" id="OFLC_0000264001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000264001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000264001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000264001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="861" mass="94580" checksum="804FE4B122E9C50C" modified="2016-09-07" version="1">MSVKKFNIYRASTSTLPEQSQVVCGSISEVESKPSAMMPPFSISTDIVGEVDLSSLSPAERNQIISVMKAAESEESNIIPPASSFISVLPPITQVDDEFHDNLARLSPFEKHQILAVMKAAQEEHFEATHAVLSHPLSQRTSGAYDEGNEWRESKNSGYTNDTCAKNAEKNILEIEKIEILTSFMESSATSSVDVTLPQLNSDYTRIEDSNCDPSVTNVNMISSVVIGTDIQEAGSPSAPGSSDYGSTDFDYTYGDDRRFIFDGVTQMEDSSKENQDADSGVGTFDWSDQGHYEWTERKPRMWTTVFSEEEEKSDIDMQKHGKSAEDYIKAVDSHHQIVALTDDSENTIKESSVITEKNLCKADTAHDSDEQCFIKTDSSSKKTVETAAQHEILKTAHIMRTPPAITVTDHGDGIRIAVDDDSDAETSPSSDEDDYPDQVIEVPSAPSKSYDEVEKEQEQQEAFGKAVLQQIQAFGEAANDEFDVQWVHDNLIKNEVISNIFAHDESTTPAVAYDTILLSVETEHADKTPNLNTINSERKNPFLNTGNNDSTLKIVEENENSLESEDLDYTAAASYYNSQSFLTHRPGSVYTIPEDKEQDDGQVSTDSKFYAKEMVRRVRAESSILKAACKSSLLSDATTALNIVSTLNSAQKDRDVTITVYSSDYYSQLQKRQNEALKQTLFHGAETDTRTPAVETNVDSFEASFQLKHITTSSSTVVQKEPAFSLSSSGVSSCNSAMLFDVSSHRMALGGFSGIKNGWIDEVEISTNSAANKNDSGTDALKMSAGITRHLKIETSPNSVCNIPSFHKKLGQSFNSPSKAKSALLSETLGSGLDSNVTAISPRFENDPIATRSPTFDLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5M5</accession>
    <name>A0A183H5M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2785</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001688">
        <property type="protein sequence ID" value="VDO34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5M5"/>
    <dbReference type="WBParaSite" id="OFLC_0000278401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000278401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000278401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000278401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7659" checksum="B2AF5800FDAA4780" modified="2016-09-07" version="1">MLAIKIRQIKVYNSSNLRLKGGADVLWSLFNGDAPLLNNQNLSPPPYTPHAPNIYVDIDVLSKARNAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5U6</accession>
    <name>A0A183H5U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2857</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001749">
        <property type="protein sequence ID" value="VDO34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5U6"/>
    <dbReference type="STRING" id="387005.A0A183H5U6"/>
    <dbReference type="WBParaSite" id="OFLC_0000285601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000285601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000285601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000698">
        <property type="entry name" value="Myoblast growth factor receptor egl-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000285601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="731" mass="81951" checksum="3E6D2941B365A075" modified="2016-09-07" version="1">MPSTYQIHVEPIATSGTRRPRLSSDLTFLSDYEIPPDPAWEVERSRLHFVEMLGEGAFGEVWKAILRIPVARTAINQGNMREEEVAVKKLKTSAHEKELIDLVSEMETFKIIGHHENLLRLIGCCTGTGPLYVIVELCKHGNLRDFLRAHRPRDADSGSQVPETTNFGASVGGNSDHYLEPRKLQRKLTIASAHDQPVLIKHLTQRHLVQFAWQVAKGMEFMASRKIIHRDLAARNVLVADGFVMKISDFGLSRDVHYNDYYRKKGNGRLPIKWMALEALDSHVYTIYSDKRLMPHIFLFSSWSFGILLWEIMTLGGTPYPSIAMQQLYSCLKEGYRMEAPDNCPEEVYDVMVACWQEKPENRPSFDTLVDYFDWMLTQSARDHENYLEVQSITSNGNEVRNIPPPPPPPLRSTESPSRHRKARPLSEPVISPSEPVVDPDSDSEFDNDSHPLLSGKKAVLYEKQSRSGVRHAFVRRCPALPIADTSLFNELSLNSTATASIDSAIGSPLWSAGATSALLDSDANERSDSPMFCKKYRLSNGPCSYSEAEEKNEITDEKNGTEDITCNSGVLYPQYVNVESAQSASAEKSKLRGTKFPFPPLRHTRFSDSTAYEADSIHMDNIRKPTFKGSSSAFIVNQASTLLTEMDKENPNETSVPKSNSSNQQRRFSIESNSSGRGGSSGMSSAEGLGGVTEFCHIECSRAETTPYELYSQQQKPERKIPLSILKVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H610</accession>
    <name>A0A183H610_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipocalin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2921</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001814">
        <property type="protein sequence ID" value="VDO34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H610"/>
    <dbReference type="STRING" id="387005.A0A183H610"/>
    <dbReference type="WBParaSite" id="OFLC_0000292001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000292001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000292001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000292001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="7152" checksum="BEF4F8B3F43B8977" modified="2016-09-07" version="1">MFYSCTLFESFVLQASQNNWPGEADWMENGKHILSKENTLKNEHAKEISAEGEPVWVMRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H770</accession>
    <name>A0A183H770_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCAPER_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3334</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002198">
        <property type="protein sequence ID" value="VDO36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H770"/>
    <dbReference type="STRING" id="387005.A0A183H770"/>
    <dbReference type="WBParaSite" id="OFLC_0000333101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000333101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000333101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000333101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11709" checksum="BA856737D19035ED" modified="2016-09-07" version="1">MDLNVASETQKTHRRTVSDIPMFDDDNDSVETASLDSLDQEVVEVLQYIIDCICAQEESEMEIRACFAGERLCSHVQTTLISDTHCTESEISEKEKSFGLVCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7G4</accession>
    <name>A0A183H7G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3426</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002280">
        <property type="protein sequence ID" value="VDO36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7G4"/>
    <dbReference type="WBParaSite" id="OFLC_0000342501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000342501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000342501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000342501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8617" checksum="1A5BF2F069A43FBF" modified="2016-09-07" version="1">MAIYWKHDLLDSLGRLGALMQPPVNSPLLSPTVTIKFIPFSIHLLLFTLCSSVVISKKVHLFNLNDRFVAVVVVGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7L5</accession>
    <name>A0A183H7L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3477</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002329">
        <property type="protein sequence ID" value="VDO36639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7L5"/>
    <dbReference type="STRING" id="387005.A0A183H7L5"/>
    <dbReference type="WBParaSite" id="OFLC_0000347601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000347601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000347601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000347601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="36425" checksum="954FE40F081F6042" modified="2016-09-07" version="1">MDHFGSPSQSTSVITSLGGQTPNSGHTVGPASILTGSGPSSVLGPASILGAPSLSLGPGSMVMGSASGPTSNLSNVGCAGPSSVLANAGPSSVLGSSILGQHGGPGSILNSQGGPGSLLSYSGERGGPSSVINVGGNPGSVFQDMNPASVGPGNLAVPMTPLAGDHFQQPASNIPMVSTNPPQTPGSQLIDVPSPALQNIVSTVNLGESSENEGGVPLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEESSRLAARKYARIVQKLGFNAKFTEFKVQNMVGSCDVRFPIQLEGLCLTHTQFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVSLKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7T7</accession>
    <name>A0A183H7T7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3549</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002406">
        <property type="protein sequence ID" value="VDO36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7T7"/>
    <dbReference type="WBParaSite" id="OFLC_0000354801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000354801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000354801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF3">
        <property type="entry name" value="PROTEIN CBG09935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552425" description="C2 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000354801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17072" checksum="EC576C305A4FD09B" modified="2016-09-07" version="1">MKIFPIITLSLSWSIFCTILDSSQAIFWLTSKLENIEWRKGCLTTAGCAQPRFQLALLNTITNEKLSKNWLITPKLMQERQRIYVTHWSDGNPNDIQISCEVVGVDPTYGFPRICDSSASINIYQNEMRNVSEVKISTAYAFMLKLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8F0</accession>
    <name>A0A183H8F0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">OFLC_LOCUS3761</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="19">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="19"/>
    <dbReference type="EMBL" id="UZAJ01002621">
        <property type="protein sequence ID" value="VDO37668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8F0"/>
    <dbReference type="STRING" id="387005.A0A183H8F0"/>
    <dbReference type="WBParaSite" id="OFLC_0000376101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000376101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000376101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000373">
        <property type="entry name" value="Mitogen-activated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDO37668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000376101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45165" checksum="2C1AFC63A26E0C7E" modified="2016-09-07" version="1">MTTTVEVQTKNGVEEVHGQIFEVGPRYVNLCYIGEGAYGMVVSALDTETHERVAIKKISPFEHQTFCQRTLREIKILTKFKHENIINIQEIIRAPSVEQMKDIYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVIHRDLKPSNLLLNTTCDLKICDFGLARVTDPEHDHTGVLTEYVATRWYRAPEIMLNSKGYTKSIDVWSIGCILAEMLSNRPIFPGKHYLDQLNLILGVIGSPSQEDLQCIINEKARSYLLSLPHKIKQPWLRMYPNADPRALDLLDKMLTFNPNKRISIEDALAHPYLEQYYDPNDEVLYFLPICEEPFTYEIEYDDLPKETLKQLIFKETEDHYKRTLVAKKVTSPEEVELDSGIDSTIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8L4</accession>
    <name>A0A183H8L4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="6">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3821</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01002687">
        <property type="protein sequence ID" value="VDO37866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8L4"/>
    <dbReference type="STRING" id="387005.A0A183H8L4"/>
    <dbReference type="WBParaSite" id="OFLC_0000382501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000382501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000382501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000382501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25780" checksum="3FC9969492089704" modified="2016-09-07" version="1">MYKEPGLEYAEWYHGLLSRKDINKLLTKHGQFLQGLQPVLSVKWNDMIMHFTICQNDGKVSIEKCEFASICELISRNLAKTSSNFVCNYRYHMITKDPITDQSGAMLLYVVPRQNWEVKHEQVKILNEFTYPSHKNSLYPIELGELLGEGALSAVYKGILKNNEREKEVAIKVRKGRRLDREIVEQICREARIMRKLEHPNLVRLYGIAISKVLNSCLINQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Q6</accession>
    <name>A0A183H8Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3869</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002736">
        <property type="protein sequence ID" value="VDO38034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Q6"/>
    <dbReference type="WBParaSite" id="OFLC_0000386701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000386701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000386701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552423" evidence="2">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000386701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10283" checksum="9754AE5A39D466A6" modified="2016-09-07" version="1">MQCVGRRTLLVVAATLIWSSVNARQIFAINSECTSCSYYTTHVCISPFLYNERLVNSIEKQISSRFQPCLNGSQQKAKQPLRSTKIIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H925</accession>
    <name>A0A183H925_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3987</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002864">
        <property type="protein sequence ID" value="VDO38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H925"/>
    <dbReference type="STRING" id="387005.A0A183H925"/>
    <dbReference type="WBParaSite" id="OFLC_0000398601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000398601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000398601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="1">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000398601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18237" checksum="D515C39BB240F9F1" modified="2016-09-07" version="1">MSVNTSSTPDGRGVLIYNGEMILLYTEQVNCHFEDGPDNIFRGNKSGNLYLTSHRVIFINRKNDSLRSFSMPFHCMKDVKLEQPVFGANFLKGIAVAQPGGEYFVNFKPRHICWMKPYNLHELILGNWNGEVTWKLTFSKGGCIDFGMALLRAVDMGLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9K7</accession>
    <name>A0A183H9K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003066">
        <property type="protein sequence ID" value="VDO39160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9K7"/>
    <dbReference type="WBParaSite" id="OFLC_0000416801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000416801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000416801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000416801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8060" checksum="96CA88073856050D" modified="2016-09-07" version="1">MVIIISGNMNRNLLILARVFARNYCVKPPGRKNWPRPMMLGPQTTRHPKFPGWSLYVSSIMFYSYICIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAD5</accession>
    <name>A0A183HAD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4448</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003384">
        <property type="protein sequence ID" value="VDO40045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAD5"/>
    <dbReference type="STRING" id="387005.A0A183HAD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000444601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000444601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000444601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF3">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000444601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55848" checksum="D5BD030C45AF1397" modified="2016-09-07" version="1">MVSLNFSFDSNFWSLADYVLNFNKCPKDVVTIISDAASVGKASFAAVDYCIRNRMLSRYIDDPTILYFAALLGPLRASSVESFAAKRTEEFRQKCRNVLLRVEKLTSSSKEWELAIVNYLGSVKQNDLNGRAVAYTYVGFRESFSTLMRDLRGLPPSDDRINVRWAHHLVKKCAAKYYYEKTWKIENLYEVIWTILAQRPSMRKFVVQTLSKDFKDPQAAEMWRICKIPSDARKHIAHNSKEEHLDPRTPNPPYLSIPESVEPIEFVRHSSHLKRVANLLEDYANDNFPPVGIDAEWSSYVSYSKATILQLAIPYHIFIIDIDGIKSDVLVDFFEKLFVEWKLLKIGYQFDEDLVQLRNAVQSCSALYHPKNLICVGKLVKSLMKESSKRPEINLDGVFHPEKVETNERPVEQGRNGIMSTEMDGGAWNHVTDCEENVEAGMNFVPVVISHVMNKSDDVALTSTIEIDGMKELATVSFVPFFLYFLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAZ0</accession>
    <name>A0A183HAZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4652</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003641">
        <property type="protein sequence ID" value="VDO40635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAZ0"/>
    <dbReference type="STRING" id="387005.A0A183HAZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000465101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000465101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000465101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000465101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36147" checksum="0B42513FBBB88DB6" modified="2016-09-07" version="1">MLTNFTCFVPSILLLLNRRSNRWAILLMVADILCIIVQIIVLWMLPNLNASFRNFTFTLPLCLILISLGWWQNFAHVESVLAPIRALARFAVQLNERRSKTYVFISVWKCIVYLLTVLFVLTNNITSKDLFKKDPFGEKLLVITARNMSQTQINKFYNRLEMEMANNGMQIKNAPPVLKNHGGRDNHDSRFFPDKSQSINRKPSPKLLPETQLFQKINEQDNRNTITSSPVIKPKELLENTVREESEKSSRNRKKRRIDDDEYEIPPNTYNIYDDYVELNQYTVPFDALWIVLIQAIAVILTYHTSKFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB50</accession>
    <name>A0A183HB50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4712</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003714">
        <property type="protein sequence ID" value="VDO40825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB50"/>
    <dbReference type="STRING" id="387005.A0A183HB50"/>
    <dbReference type="WBParaSite" id="OFLC_0000471101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000471101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000471101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000471101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20669" checksum="B3912DA1657E07E5" modified="2016-09-07" version="1">MQRESFNSASAFRSSVSSKACGSYECGYMLRSNRQEKIIEAKRRVIRMLITIVIAFVICWTPSFIWWLTIRTTDLIRIHLWNRRANAYITLLTHISACANPITYCFINERFRKHITAYLCSCTYQTYKEPLQEKSAMNQYSLRRAKFMTQYNDDLFSNESNVERAVAIPFLSNDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCD9</accession>
    <name>A0A183HCD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vac14_Fab1_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004282">
        <property type="protein sequence ID" value="VDO42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCD9"/>
    <dbReference type="STRING" id="387005.A0A183HCD9"/>
    <dbReference type="WBParaSite" id="OFLC_0000515001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000515001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000515001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552475" evidence="1">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000515001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15863" checksum="B71038865032F705" modified="2016-09-07" version="1">MLLELDLTLFITEVLGYLSQYDLQSDAIKNMVDAQYAPLTATLVRTLTDKLYEKRKAAALDIEKQVRDLLQANHLSQLEKLLVVLKGLTIAQNAHVRKGGLIGLAAAAIALGKNTADYTSQLIEPVLTCFNDPDPRVRYYACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD70</accession>
    <name>A0A183HD70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5432</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004663">
        <property type="protein sequence ID" value="VDO43127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD70"/>
    <dbReference type="STRING" id="387005.A0A183HD70"/>
    <dbReference type="WBParaSite" id="OFLC_0000543101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000543101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000543101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000543101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49053" checksum="222B7A8625B679F7" modified="2016-09-07" version="1">LLPGCYELADGDYSTGCVADFITCTDGSEIHKKCPNSTVFSNVLRECVDYEQCAFLMYRVLASFYPSDRALSQWLKHKSARTIPSVSPPELSLPEANSSGGKSCRYVQAHCLSTSNENAVNMPVSGGDMNRCEYAKKQCINEANEKVYQISTVEHQETSGSHSEEANKNHFCLQEISERETDSIRCDKMDDGLYAFDCSNKIVVCSSSWRKIYGCPRGKLFIPALLKCDDFWKCTKTNLCRSGFVGVIYLGKVGSMRLSTSLPSTNSFSCESKEDGNYGKQCSPIYIKCIQQKRFLMRCSIGQVFDQRFRRCIPSKHCPMLLTNLVHDSLKHSSQLNPYLKPNQYDRSLYNLGLPYMQPITATSYGNPYMFSGMLQAPSSSTYIPQMPSQQHVPSIFDNSAGPFRIVKDTFRFIPSLVVSNSVSLRFRLNIQTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF25</accession>
    <name>A0A183HF25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6087</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005590">
        <property type="protein sequence ID" value="VDO45348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF25"/>
    <dbReference type="STRING" id="387005.A0A183HF25"/>
    <dbReference type="WBParaSite" id="OFLC_0000608601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000608601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000608601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO45348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000608601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21340" checksum="05FEF06B30FA89C8" modified="2016-09-07" version="1">AASAASYAPSANRQYPSQIQYSSTKTLRTTNPTHPYGAVRSDISIDITKRPYDRIRGATISDELTARNNYRAPSPMALSWVHCNNCYLIPSAQSTIKREPFALASCGHIFCSTCLDKCVSGKMCIVCRRSPFSYESVGRHMSEKTKKYFQTPNTLLVNALRKITSVIKFQQNQYNIMRNNVNRMVSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFI0</accession>
    <name>A0A183HFI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6242</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005824">
        <property type="protein sequence ID" value="VDO45885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFI0"/>
    <dbReference type="STRING" id="387005.A0A183HFI0"/>
    <dbReference type="WBParaSite" id="OFLC_0000624101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000624101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000624101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000624101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19896" checksum="857B1A0054D1D760" modified="2016-09-07" version="1">MWNRQDIMEFKNAIRKEGSESIIKVGHGETVTVRVPTHEEGSCLFWEFATDHYDIGFGVFFEWTISQTNRVSIFKVSVHVSESSDEEADEEFLQADLSGDLESGSSAKEKQMDQNKPHVDEIVPIYRRDCHEEVYAGSHLYPGRGVYLLKFDNSYSLWRSKTLYYRVYYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFM4</accession>
    <name>A0A183HFM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6286</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005885">
        <property type="protein sequence ID" value="VDO46028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFM4"/>
    <dbReference type="STRING" id="387005.A0A183HFM4"/>
    <dbReference type="WBParaSite" id="OFLC_0000628501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000628501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000628501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000628501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17520" checksum="930CEA1092EED0CC" modified="2016-09-07" version="1">MGKVDSTIPESSAEQQLPEEIAVEDKPLPTSPSLIPSADIKYNEIELDNLPLHQKHIMNRLESIRGNKQRILATLRELKENAAEGELPNKELMSKMIGSYDALTAQEEQYVQLMQKIVVSLTLHENAAEDVQHENERNSEKLITDGDNNTNQSSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG04</accession>
    <name>A0A183HG04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leukocidin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006081">
        <property type="protein sequence ID" value="VDO46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG04"/>
    <dbReference type="WBParaSite" id="OFLC_0000641501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000641501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000641501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000641501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9124" checksum="EEBA10F6A48D4AE9" modified="2016-09-07" version="1">MNLKTDVTYTVSINDEGLTATVHMNRSIICEKLWINRYPYTVRYKQVGGYIRYTADKWVNSIRYGAKTNNSIIWGQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG97</accession>
    <name>A0A183HG97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4604 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6508</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006215">
        <property type="protein sequence ID" value="VDO46768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG97"/>
    <dbReference type="STRING" id="387005.A0A183HG97"/>
    <dbReference type="WBParaSite" id="OFLC_0000650801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000650801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000650801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000650801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16299" checksum="4864437DBD74AA70" modified="2016-09-07" version="1">MGEFTPKFERDLESRSTGPKALPTAGAIAVRNEKGEMTMQKVKVVRYMAGKVPTYALGKNDSSGGEQSDEEQEKPLNDTWQRETKRTTDVSKEEVGAASSSDDDEEAEKRRTRARLRRMQLEMQEAPVEEDEPDEDDEVSMIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHF1</accession>
    <name>A0A183HHF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low-density lipoprotein receptor-related protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6914</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006877">
        <property type="protein sequence ID" value="VDO48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHF1"/>
    <dbReference type="STRING" id="387005.A0A183HHF1"/>
    <dbReference type="WBParaSite" id="OFLC_0000691201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000691201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000691201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000691201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34885" checksum="559630C6282406D8" modified="2016-09-07" version="1">MHNAGRIEVCPLDGQTSCAIALYSGFENQNSRVDALHSLVLDPVDGYMYWLNRVHKRIERAWMDGRHHDPHCFKDDTTDVIATSALTLEQASRMLYYVRTRTSLDNSQIWSCSLYDRESCRAVINKVNAFYLDVFSDYLIWTSVTSQNSGITICEKVDCDHTAREVVNSSGVEALIVFDKQIQSLRQSLNPCGSKNGGCSHICVLIPGVPWRSCLCPVGVRLLQDRLTCSPNGIERLLYVATISGLIFISLDTAHHTPLPFPNAASEIRDTKVVHIDFDPVDKKLFMIDGDMGVIRRCNPDGTGMEVITLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIH8</accession>
    <name>A0A183HIH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007497">
        <property type="protein sequence ID" value="VDO50238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000728901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000728901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000728901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000728901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16706" checksum="323D958E755CFC44" modified="2016-09-07" version="1">MLCPDKSREQSKQLELSKAIALASHYEKLIDSKRLRSIRQAVIYMRELDTIEDRIDSIIETLDQITNEVDNKIDCCAVNFKKAFTLIAVSRNGLCQNQFLSVQLQKQQKTINDIAHQFSNSMRLINSMHDNFEEYKSLLKKVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ09</accession>
    <name>A0A183HJ09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3967 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7471</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007826">
        <property type="protein sequence ID" value="VDO51145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ09"/>
    <dbReference type="STRING" id="387005.A0A183HJ09"/>
    <dbReference type="WBParaSite" id="OFLC_0000747001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000747001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000747001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000747001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="8008" checksum="492B7EE8ED5ACF6B" modified="2016-09-07" version="1">MQTELDNEKVRRVEMEQMWHSQKKKLDEERLKFESERKDWEKERERLLMDRDELVAELKEVAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ58</accession>
    <name>A0A183HJ58_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7521</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007910">
        <property type="protein sequence ID" value="VDO51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ58"/>
    <dbReference type="WBParaSite" id="OFLC_0000751901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000751901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000751901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000751901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13599" checksum="C53304951A991AB0" modified="2016-09-07" version="1">MKFHSLSSVPGRHYFGLRPEECDPAGCMVELVIQLAIIMCGKQFWNGFVEFAWPVLMTWLRSLRLLETKKQRDERTKHELIEKLSGRGRIAKWEQDYILNPVYGQFLFDEYLEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ81</accession>
    <name>A0A183HJ81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7542</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007950">
        <property type="protein sequence ID" value="VDO51462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ81"/>
    <dbReference type="STRING" id="387005.A0A183HJ81"/>
    <dbReference type="WBParaSite" id="OFLC_0000754201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000754201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000754201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000754201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13801" checksum="FA1989D32C23B8E7" modified="2016-09-07" version="1">MIFQWSDSVELNVNDEICQIAKERILSNNFIKKFEITHYMEDIIQPPVSPVTGQGVTIEHPYILLFVAGVPTESHFGNLEPIYRSTIPNLLGCMRGLMIGDKLIDMRDQYFWSHYPTEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKX9</accession>
    <name>A0A183HKX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008985">
        <property type="protein sequence ID" value="VDO54228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000814001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000814001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000814001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552567" evidence="1">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000814001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14488" checksum="E487635569BB323C" modified="2016-09-07" version="1">MALFLIISLNVKIINADVENYMDFEDLNNKKLKIRSVSVPDQSDDQGSGNISEEQIQELSKEVIADSESFDINRVPLSLGDQNVMDLVIEMPTKRYSGRLCGTRLMEVILRVCNGCVKPLGSKLVEIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLZ1</accession>
    <name>A0A183HLZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009670">
        <property type="protein sequence ID" value="VDO55994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000850201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000850201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000850201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000850201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7722" checksum="4DDDD0F2EFCA8CE5" modified="2016-09-07" version="1">MQDVEMVKAHQKSAFFVTKSRPRTEKSVRSKLEKTHDYKYNDIRKYILASLASYTLQLRLMNHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMV6</accession>
    <name>A0A183HMV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8819</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010287">
        <property type="protein sequence ID" value="VDO57553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMV6"/>
    <dbReference type="STRING" id="387005.A0A183HMV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000881701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000881701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000881701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000881701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16012" checksum="ECE344D7500F9FA0" modified="2016-09-07" version="1">MHLKKISSSLKRKLEKERGKARRKKSAKLQKISEYNCKKVDGSLPKKYQDACSSDESSWSDYGPSSSGNHRSSTPFAFRADRYTSDVSESDSEIDPEFEAHKQLLRRQRWEELRGKFETQQKWDEDRERNFVFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNA8</accession>
    <name>A0A183HNA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8973</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010576">
        <property type="protein sequence ID" value="VDO58227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNA8"/>
    <dbReference type="STRING" id="387005.A0A183HNA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000896901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000896901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000896901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO58227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000896901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11117" checksum="EFDCC994BA48BCB3" modified="2016-09-07" version="1">MFMGRRYSEPTLLMPHHHSGSGRRKSREGQVNYLWEFLLRLLQNKEYSPKYIKWLDYSKGIFKLVDSKAVSRLWGLHKNKPGMNYETMGRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNG5</accession>
    <name>A0A183HNG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IC domain protein, HAD ATPase, P-type family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9028</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010688">
        <property type="protein sequence ID" value="VDO58423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNG5"/>
    <dbReference type="STRING" id="387005.A0A183HNG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000902601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000902601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000902601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF506">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE PMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000902601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14198" checksum="02A9FD6B6D19FF64" modified="2016-09-07" version="1">MVGIMDPPRPGVAESIEIVQSAGVKVKMVTGDALETACSIGAHLKLFTADDLCLSGPEIDRMTDLDLERVIKAVTIFYRTSPKHKLRIVKALQNLGDVVAMTGDGVNDVVALKKADIGIAMGSTGTDVCKVVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP03</accession>
    <name>A0A183HP03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharide flippase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9214</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011068">
        <property type="protein sequence ID" value="VDO59184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP03"/>
    <dbReference type="STRING" id="387005.A0A183HP03"/>
    <dbReference type="WBParaSite" id="OFLC_0000921401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000921401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000921401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO59184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000921401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13571" checksum="1B6E99F971F9FB1A" modified="2016-09-07" version="1">MKDLIVSKIDQLLHFVFPNRCYELMLLKYDFLNQECVSMVMSRLLGLGITLGSMLIFIPQILKIQFAQSGEGISLLSQLLGLFACFVITSYSYAKGYVFRFVIFSFYFHFFFNKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP38</accession>
    <name>A0A183HP38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1088 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9251</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011156">
        <property type="protein sequence ID" value="VDO59391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP38"/>
    <dbReference type="STRING" id="387005.A0A183HP38"/>
    <dbReference type="WBParaSite" id="OFLC_0000924901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000924901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000924901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1088" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000924901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23455" checksum="9746DF94863F2E07" modified="2016-09-07" version="1">MAHATRDHILRVANEADFILNRLRAEDISKHAQFESDAAEQMHRRRKEEQVNDHLVTANRKRDLLVSARLLERLTSLLSYSGGAWNDPCQNLNTFWKLDVWEDDSRRRKRFVRNPYGCHHSAACLKTVLENKSSDKEVDKAREDLLRDLIAQRLISLGSLKAGSALSELVDETDFEKWATEPDAAIDLQKGRKFPKSYLAVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPB5</accession>
    <name>A0A183HPB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9327</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011324">
        <property type="protein sequence ID" value="VDO59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPB5"/>
    <dbReference type="STRING" id="387005.A0A183HPB5"/>
    <dbReference type="WBParaSite" id="OFLC_0000932601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16123" checksum="B8D1C830EC1278AA" modified="2016-09-07" version="1">VLLTLPNITIFLRSRDSYLKRVQREENQSNEEIMEVNKNAEKLEPTSDEAINETESLLSKDEQGGDDGIKAKKGSKKEVIVHEPAVLIEGVLFRARYLGSTQLICEGRPTKASRMMQAQEAVARVKVRKILFYFIKISKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPP0</accession>
    <name>A0A183HPP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011593">
        <property type="protein sequence ID" value="VDO60734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPP0"/>
    <dbReference type="STRING" id="387005.A0A183HPP0"/>
    <dbReference type="WBParaSite" id="OFLC_0000945101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000945101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000945101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000945101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7913" checksum="5BF94CAB04FE9A1C" modified="2016-09-07" version="1">MTDWTCVSFDEAKNTLRKWREDHARRSVETVGLWQRILSHRPRSLGDELWLVYEQIVTSLTYYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQB9</accession>
    <name>A0A183HQB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012136">
        <property type="protein sequence ID" value="VDO62416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQB9"/>
    <dbReference type="STRING" id="387005.A0A183HQB9"/>
    <dbReference type="WBParaSite" id="OFLC_0000968001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8667" checksum="964B4EF6A1341AF1" modified="2016-09-07" version="1">MTNDNLLIMKLTANFEILSESQSQNRSVTTVKATCALKDRPALRLDSRLVCKYEVLAVIGKGSFSQVRFVTVIELFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQH4</accession>
    <name>A0A183HQH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9735</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012266">
        <property type="protein sequence ID" value="VDO62870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQH4"/>
    <dbReference type="STRING" id="387005.A0A183HQH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000973501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000973501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000973501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO62870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000973501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19547" checksum="8975FA98E3FF6504" modified="2016-09-07" version="1">GWVARFVRRNNITLQVTNSTSTISPKLVTKSDNNSNIIDNLINRSDGNPICCNTSNMMSNSSCPLPSTASRISDLTVANANMCRQNDVTKVNATTITTTTTISTTTTTMTTATVAITTINNNSTISAKKRRKNFTPKKVVPNDRGVYSEAGKFGLPVEYSIRNTVFHVLFITINTVSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR92</accession>
    <name>A0A183HR92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SLC3A2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10007</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012881">
        <property type="protein sequence ID" value="VDO65083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR92"/>
    <dbReference type="WBParaSite" id="OFLC_0001000301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001000301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001000301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO65083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001000301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10560" checksum="31CDAD2219EC89D1" modified="2016-09-07" version="1">MDSEMLTPLESPNISPSSEAKNVKDVVQTLDFETVGSEMIGQEQKLGIQEWLNLTLDRECTPVLYVYFAGIAILVVITAGIVVIVGMQSNWNFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRC4</accession>
    <name>A0A183HRC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10037</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012955">
        <property type="protein sequence ID" value="VDO65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRC4"/>
    <dbReference type="STRING" id="387005.A0A183HRC4"/>
    <dbReference type="WBParaSite" id="OFLC_0001003501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001003501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001003501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001003501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9701" checksum="24D33AFB6C287FCD" modified="2016-09-07" version="1">MARWTIVYYLICCYYCPLATVLAFNLDIHAPIYKIGPNGSYFGFAVAEHFKANLPVEMLEEEDERSKMLINEVSHAFPRAKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRU5</accession>
    <name>A0A183HRU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZU5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10202</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013342">
        <property type="protein sequence ID" value="VDO66628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRU5"/>
    <dbReference type="STRING" id="387005.A0A183HRU5"/>
    <dbReference type="WBParaSite" id="OFLC_0001020601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001020601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001020601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001020601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13895" checksum="0A84E6D54E1424C4" modified="2016-09-07" version="1">MIDFRGGILNCPKTGVSLIIPEGAINEGVQQEIYVKVCRASDPGNRPPLDESRGESLMSPLVMCGPQDLQFNVPVELRLPHSVSNSSENWSLALKSGTGQQWDQMALDKNTSSVVTDHFVSIKISHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS95</accession>
    <name>A0A183HS95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Yippee domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013707">
        <property type="protein sequence ID" value="VDO67808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS95"/>
    <dbReference type="WBParaSite" id="OFLC_0001035601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001035601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001035601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001035601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5244" checksum="AC272B76FA315D16" modified="2016-09-07" version="1">MSFGICKSYYRIMHSTISDGNLLRNTHPLQFYLRNCKCDSCIAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSY4</accession>
    <name>A0A183HSY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10591</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014291">
        <property type="protein sequence ID" value="VDO69779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSY4"/>
    <dbReference type="STRING" id="387005.A0A183HSY4"/>
    <dbReference type="WBParaSite" id="OFLC_0001059601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001059601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001059601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001059601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6865" checksum="303E67A041D3A127" modified="2016-09-07" version="1">IRIEILDVDEPPAFQNGPKPYQAVVAYDQPIGMHIYQFVARDEAGDGDDDVEYRLINTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTT5</accession>
    <name>A0A183HTT5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10896</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015070">
        <property type="protein sequence ID" value="VDO72222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTT5"/>
    <dbReference type="STRING" id="387005.A0A183HTT5"/>
    <dbReference type="WBParaSite" id="OFLC_0001089701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001089701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001089701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001089701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9887" checksum="E7E93165A5D4B0DB" modified="2016-09-07" version="1">MNVIQRVCMEYEKDESEDLEEMKRRFDNITALMMELQSYGYPPEELVGEAPPGWVTDPQTGLPKVDDVSKAAEFCSLIRINYFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU01</accession>
    <name>A0A183HU01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10963</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015245">
        <property type="protein sequence ID" value="VDO72732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU01"/>
    <dbReference type="STRING" id="387005.A0A183HU01"/>
    <dbReference type="WBParaSite" id="OFLC_0001096301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001096301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001096301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001096301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7842" checksum="5AC394654E761753" modified="2016-09-07" version="1">MEEVKRRCISPPDAKTINAIISIKTENINWTSQQEIMFIVLRRIYKNDFSPISPKADVSPNSPPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUR9</accession>
    <name>A0A183HUR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015958">
        <property type="protein sequence ID" value="VDO74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUR9"/>
    <dbReference type="STRING" id="387005.A0A183HUR9"/>
    <dbReference type="WBParaSite" id="OFLC_0001123101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001123101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001123101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001123101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14616" checksum="C15CEAA31D6D5EB7" modified="2016-09-07" version="1">MVEKHMDLERIREMQKYFEQYTEEFVEMETQETPCEIITKSDRLRQRLEPLLNFQQDSSASPFSVKEIVDILRAERAEDIICIKVPIDDSQNRHVIICTPHNMRHGEAIVLAIRKCFKLKTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVG2</accession>
    <name>A0A183HVG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11474</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016604">
        <property type="protein sequence ID" value="VDO76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVG2"/>
    <dbReference type="WBParaSite" id="OFLC_0001147401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001147401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001147401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001147401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10952" checksum="5DE7D4D69379BC45" modified="2016-09-07" version="1">MKRDVNAFIDYTYVKNDDQTTSYPKIPLNYPLNSLSRGSNKLNHSMPLRRTRNENAKPNVNVLRKELIRICSKRKSVDLKAYLDIHFYALDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVU1</accession>
    <name>A0A183HVU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger BED domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11604</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016971">
        <property type="protein sequence ID" value="VDO77750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVU1"/>
    <dbReference type="STRING" id="387005.A0A183HVU1"/>
    <dbReference type="WBParaSite" id="OFLC_0001160301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001160301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001160301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001160301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15909" checksum="38C6BA22F110545D" modified="2016-09-07" version="1">CIHIYRLATDEDETVTFTLTSPTSQKENNAVDILAEKLTAELIEEEVMRLCKLTYSKSLAHSLTTTLYGNILEDCLKPCCQEILIAAKLLHRRKLAASVAKQKEDEIRLLLDSLNESVLHEVVDKFIEDISKKWIMYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWA8</accession>
    <name>A0A183HWA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11768</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017456">
        <property type="protein sequence ID" value="VDO79072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWA8"/>
    <dbReference type="WBParaSite" id="OFLC_0001177001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001177001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001177001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001177001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7495" checksum="AF1AE1CF4FC2194D" modified="2016-09-07" version="1">MTESSLVTVIVAIVVAVIVAVVATVVVVVVIHDDGLQFQRLLFGQTTEHPIAEVDFDDDEEGGKAVKFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWS7</accession>
    <name>A0A183HWS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017889">
        <property type="protein sequence ID" value="VDO80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWS7"/>
    <dbReference type="STRING" id="387005.A0A183HWS7"/>
    <dbReference type="WBParaSite" id="OFLC_0001193901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17677" checksum="992FFC2B75272343" modified="2016-09-07" version="1">MLKKRTKHKKRRKNENGSGDENGTPDMEAVLNQMAIAFEQHQSSLNSLNEASINFGMEVTPSTTEIQQHSQTSSHISAENSPFIGSTGTGEEEEDDDLSGEQDVQTVSTGDEPEIEISKSKKRRERRLRLQKQFELMKTGNFWKINEMQKEKFGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXC9</accession>
    <name>A0A183HXC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12149</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018487">
        <property type="protein sequence ID" value="VDO82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXC9"/>
    <dbReference type="WBParaSite" id="OFLC_0001214101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001214101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001214101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001214101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3607" checksum="3828B7E50EF06AE2" modified="2016-09-07" version="1">MKMIENAVMIMMIRERLLIRLFPIILVFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXE3</accession>
    <name>A0A183HXE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor RpoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12156</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018513">
        <property type="protein sequence ID" value="VDO82373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXE3"/>
    <dbReference type="WBParaSite" id="OFLC_0001215501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001215501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001215501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001215501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5486" checksum="453E3D6328AA8F5C" modified="2016-09-07" version="1">MSRETEVEADDEETEEEFLIGDNDNDNELKDVLRDIAKLNENDIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXX5</accession>
    <name>A0A183HXX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12338</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019055">
        <property type="protein sequence ID" value="VDO84045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXX5"/>
    <dbReference type="WBParaSite" id="OFLC_0001233801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001233801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001233801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO84045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001233801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7986" checksum="392DBD5D8FBE4CDF" modified="2016-09-07" version="1">MFTQSEINERKMLIAVCFRDQSGCLANATLRMDGQSRREGNGRSSLSWIQDSLPLDGRVYARRQVPILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY28</accession>
    <name>A0A183HY28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039834">
        <property type="protein sequence ID" value="VDP11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY28"/>
    <dbReference type="WBParaSite" id="OFLC_0001239101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001239101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001239101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552668" evidence="1">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001239101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11797" checksum="A282D9060BB292B6" modified="2016-09-07" version="1">MRRITLLFTIIYTVSAQMTFTDNWDKRALPNLFRGWQQDDLQRRKIENNFRTINEACSWNIIAEVIRELKQIYKRQNELINLIGRCNVLEHPVFVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY34</accession>
    <name>A0A183HY34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12396</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039835">
        <property type="protein sequence ID" value="VDP11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY34"/>
    <dbReference type="STRING" id="387005.A0A183HY34"/>
    <dbReference type="WBParaSite" id="OFLC_0001239701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001239701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001239701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000070">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="397"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="795"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001239701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128442" checksum="07B376C17DC5D629" modified="2016-09-07" version="1">MALNYIVTAYKPTVVTHALVGSFIVPTELNLVLAKTNRVELFLVTPEGLKPHRECPVFGRIATIKLFRAPDEDVDSLLILTAKYHLAIIRWTATSELRTRASGHIVDRVGRPSETGMIATVHSSGLMVFRLYDGLLKVVQWNEGKDLRGFNVRCDDLYIIDITFMSDPDRPTLAYIYQDDNGRHIKVVTLNIDDKELSSPLWKHDNLEGEASMVISVPEPVGGCLIAGPDAISYHKGGDDALRYAGVPGSRLHNTHPHCYAPVDRDGQRYLVADLAGNLYMLLLELDRDHEDDNLAIIVRDMKVESLGETCIAECMCYLDNGVCFIGSRFGDSQLIRLSTEPRADGTGYISLLDSYTNLAPIRDMTIMRCNGQQQILTCSGAYKDGTIRIIRNGIGIEELASVELKGIKNMFSLRINDHEFDNYLILSFDSETHILLINGEELEDTQIAGFATEGATLWAGCLFHSKTILQVTHGEVILIDGSNIQIWKAPKWITLVAVNEITGMNLLLPIIGQLVVACGALLVYLEADLAGIKVITELECEFEISCIDITPIGNNTVRSEICAVGYWTDLSVALRTLPQLMEVVREKIAGDMLSRSIMLSPMEGHVYLLVALGDGTVHYFQIDMKTGALLDPKKATLGTQPIHLRKFRSRCSPIHNIFVCSDRPAVIYSSNQKLLFSNVNLRMVSIMTPLHAEAYPDALVLTDGHSLVIGRIDDIQKLHIRTVPLGESPSRIAYQSETNTIAVTVERLEFVDAMGKHHFGQCASKNAMETSSSRLSSMRREPTPECLAEEMEVSSVLLLDSNTFEILHSHELEGSEMAMSLASCQLGNDSQPYFVVGTAVIMSDETESKMGRILMFQASEGPERMRLVYEKEIKGAAYSIQSMDGKLVVAVNSCVRLFEWTADKELRLECSDFDNVTALYLKTKNDLILVGDLMRSLSLLSYKSMESTFEKVARDFMTNWMSACEIIDSDNFLGAENSFNLFTVIKDSFTVFKEEGTRLQELGLFYLGEMVNVFCHGSLTATQVDVAPLYHSSILYGTSDGGIGVIVQIPPILYTFLQDVQKRLAEYTENCMRISHTQYRTFETEKRSEPPNGFIDGDLIESFLDMSKDSVGQIIKGLKMPLLNNISAFETTELVDATAEDVLKLVEDLSRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ21</accession>
    <name>A0A183HZ21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12733</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039917">
        <property type="protein sequence ID" value="VDP12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ21"/>
    <dbReference type="WBParaSite" id="OFLC_0001273401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001273401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001273401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001273401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13949" checksum="856B96BFA3984A10" modified="2016-09-07" version="1">FFGEFRKNGSFEFIEPPTKLACNPRVNHCFVEFYRLAYFTWFNGQCDNSFACIHESDYSFSSGCQATLHGGDRCCCSYKLCNFDIILKERPYFAKYLPQQKVLKSENILLESHCGKVKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ78</accession>
    <name>A0A183HZ78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12790</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039933">
        <property type="protein sequence ID" value="VDP12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ78"/>
    <dbReference type="STRING" id="387005.A0A183HZ78"/>
    <dbReference type="WBParaSite" id="OFLC_0001279101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001279101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001279101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001279101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="66601" checksum="D0EC26E213E1A5EB" modified="2016-09-07" version="1">MRFSAQIIYGLYQFNEVQKRQIITIHNHLRAREPASNMQELVWDQRLADLAYGHAMRCDAWHRSAYERRGHGYFYIGENIWWSNEAYLRPYLQSVMLDFFNERPYYDYNTNRCMEGAQCGHYTQFVWGETCAVGCAAVHCNGIRNGRGIYQGHIIICNYGEGGNQFGKRPYLYGPRCTRCRCGGPCTSEGLCPSCCIGLRYFQQSFLYPPAPITEQYRKSWQNKVCIQQKQKNYEQKRNNKLYNCAKMELYFYSNVLSHKISECRDLDPYCEYWARTIGCHSNYRDFMIKRCPKTCKICYPLISAKSQVRNCVDKNSNYDLWVRYSECICSWKTYLSTSCQHSRGFCTPSIHHERRYQNNSLNGILSIILYSLKNSKRILKYLFNDMTSKRNVFHGLAKKSEFPVATGFHLIILSLVNCTCDGYSSYHRMDYGYSIQIFPKWLESVIQKLSDAIFKYPGLVVTVLLTFCISFIIFKKIIDHQLYEYYKTILRYEVTLQLLKDALEENYKDYHWNDPKFCKAYLELYAAYRELRMMAKRDYRGEVDPGDERWIRFDDIKPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZA8</accession>
    <name>A0A183HZA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12820</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039945">
        <property type="protein sequence ID" value="VDP12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZA8"/>
    <dbReference type="WBParaSite" id="OFLC_0001282101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001282101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001282101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001282101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11464" checksum="C940A32F384B2B08" modified="2016-09-07" version="1">MLSSPTIKKHTQTHITANVESRALWNRSRYLSMVLLMVLALVVPLVFHNTTSIHHYFSFHSHCHSMLLFLAQSTEITLELYNFLYDFINFYRVLFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZJ3</accession>
    <name>A0A183HZJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12905</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039971">
        <property type="protein sequence ID" value="VDP12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZJ3"/>
    <dbReference type="STRING" id="387005.A0A183HZJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001290601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001290601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001290601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001290601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="28957" checksum="5B3DEF49F7D7E508" modified="2016-09-07" version="1">MEYKFQPNNVGHPGDLYQPIQSIQETVIDADQNVPVTDLSALQMSSNTQTQDAANPAQNDDSVFSPIKPATFYSNPTQNGQLYYQGTPKMPDSYGTGGQFYPSLFFQTWPYPSATANSSVAATIAGASPCSSNATELSFTQSTTVITDPTQMLVAPNQTTAQNFFPQTYQAYSTTDYYNPLHSANLLAAQSRLTTPTVACSSSGSASSRSSTGVSGAAPEGRECVNCGAVQTPLWRRDGTGHYLCNACGLYHKMNGQNRPLVKPKKRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1M3</accession>
    <name>A0A183I1M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040307">
        <property type="protein sequence ID" value="VDP14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1M3"/>
    <dbReference type="STRING" id="387005.A0A183I1M3"/>
    <dbReference type="WBParaSite" id="OFLC_0001363601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001363601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001363601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001363601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27401" checksum="CE448BF90B621462" modified="2016-09-07" version="1">MNHNNWWTGDDLPPPSMRVKYKHALVQRFLPSSRLSQQNRQSDEKDKILEQRLTNLNMNKSEDEIETLASLEERAKMLKMHNGNQDTPSVSDIEERLAKLRDVPVESIGNSRFAVVNGDETEEETVEKLMRRAKDEAMLETMCDRSGKSGKHNVDPEEFIRICRNDASFPDGISIYIFQYYFSFNKLAESLLGTVIYLYFKIVLEAEKAENEAIQIIKDSKKNGKKSGIFSRIFRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1R2</accession>
    <name>A0A183I1R2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13674</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01040327">
        <property type="protein sequence ID" value="VDP14355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1R2"/>
    <dbReference type="STRING" id="387005.A0A183I1R2"/>
    <dbReference type="WBParaSite" id="OFLC_0001367501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001367501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001367501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="9">
        <location>
            <begin position="93"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP14355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001367501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55090" checksum="B034FAF7EAA15FCF" modified="2016-09-07" version="1">SEQVPVGSIPRSLTVNIIGENTRVCVPGDVVRVTGTFAPLMRTGFRQFTGGLTTEVFIEAHHIENVNMNNEDILGEQYELTDEEIEVVSQDNFYELLAYSIAPEIYGHLDVKKSLLLALVGGVDKNVKGMKVRGCINILLMGDPGVAKSQLLSYVDRLAIRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADRGICCIDEFDKMMSADRTAIHEVMEQQTISIAKAGILTTLNARVSIIAAANPSFGRYNPKRSIEHNIDLPAALLSRFDLLWLIQDRPDRENDKRLAEHITYVHMKGREPEKEGMKPLDMSLIRRYIALCKRKQPIVEEKLRDRLVDMYVDLRKDARNNKNSVFTSPRSLLAVIRLSSALARLRLSDVVQSSDIDEAVRLLEVLRFCLACRASITIEQLKQQHEISLLDQAFAVIRDLYHGISDDENHSLPLQTVYKKCFAKGISEEVVQECINTYTANGILMLDRQQRIVFTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1U0</accession>
    <name>A0A183I1U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13702</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040347">
        <property type="protein sequence ID" value="VDP14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1U0"/>
    <dbReference type="STRING" id="387005.A0A183I1U0"/>
    <dbReference type="WBParaSite" id="OFLC_0001370301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001370301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001370301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF354">
        <property type="entry name" value="GM14138P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001370301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62339" checksum="9BAA9683AD411FE6" modified="2016-09-07" version="1">MLAKVRSAIGGSAVNDNDQDNSRNDAQIGLVIDVTESDFFGSLLPAMANSQKLRYPYTRPEFLHFSDEEISLSADQSTRPILCPKDPSKIPVYAGYAEVINAGKTVQNEDQASAKLLNLIQQGCDAEEARDLTVHDQQTENEKHSSRTSNEIPKDSTRNINAIKQHADDELIIVPEKCISNADDPAMERAGAIFFAIFDGHAGSGAAIMAANCLHEHIRNRLCQVLETVVYLNKQESFFGCPTQLSSSYALLNTCNSSYPNHNITCDSLVVGAIEAAFIDMDDQIAEERQLWRIRGGCTAIAALFFLGKLYVANAGDCRALLVTTKDTQQLSHDFTPETERKRLQFLAYKNPDLISNYFTRYEYNRFLTRNDLRRKVLYRDWFMDGWAAKTVRESDLKMPLISECGKKRRLLNTIGVSRGFGDHNLFTIDNKIPIKPFLSPVPEVKVFDLYKFDSLCDKDVLVLASDGLWDVLNNDNVSMIVKTALNNSESADYLKYMIAAQELAIAARGNPTKSYRWQMPDGDYASTDDITVFIIPLKYALLATRRADDDVELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I208</accession>
    <name>A0A183I208_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040385">
        <property type="protein sequence ID" value="VDP14611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I208"/>
    <dbReference type="STRING" id="387005.A0A183I208"/>
    <dbReference type="WBParaSite" id="OFLC_0001377101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001377101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001377101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000768">
        <property type="term" value="P:syncytium formation by plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.60">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3980">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029213">
        <property type="entry name" value="Fusogen_EFF/AFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043076">
        <property type="entry name" value="Fusogen_EFF/AFF_dom3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415">
        <property type="entry name" value="EFF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415:SF2">
        <property type="entry name" value="EFF-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14884">
        <property type="entry name" value="EFF-AFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001377101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62215" checksum="A775072B38FDB380" modified="2016-09-07" version="1">MNIRIGLQNTACFRLENITNDRDPLFTDVLNARSQDEGWLHTLTLSRLEHHHPISQQYEFAIPEVRTSCICECDVNSDVCSARTYSFTHCSNTNITQSLQENCFRTFHPNQADTGCSPGSQSKLCCEVSFTPYQNKSYVAIKLEQPTTFVTFKYVAYDYTAENFLLLTSKFHESKFRWRRLELGVSAGGRASHQLETGMYFAANNPDSEMDELRQQIINEINENNFEKLGWFRKDALGHFIIRNGKVKIQRIHLAKVENCKDQKSQSFLDAHHYVDYNDPENPERFALEAAVKRIYPWIRSAKVANGSGRHVVVTHSEGTNVEVALQLHEEKYSLSFVHDFSKMDDFSGTVIVDFKSNRFFNLTVYNATGIIHGTVKKSTDKSSSDEFHFTTYIGDMRNANKTLIVPLPALIDGGDRMICLHADNGSSEQEICRIIAFKEVALEINLLENTWREIDGHCPECNKLTMGGFLSNFNPINWASGISSISNFVMMITDVIVYIILLLIIYFILTRCLIPCCRCAFCFSTSSLCCSFNSPRCKSKNAQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2B9</accession>
    <name>A0A183I2B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC173 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13881</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040447">
        <property type="protein sequence ID" value="VDP14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2B9"/>
    <dbReference type="STRING" id="387005.A0A183I2B9"/>
    <dbReference type="WBParaSite" id="OFLC_0001388201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001388201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001388201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 HEAT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001388201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="696" mass="79555" checksum="E7F58CDCEC9DD56E" modified="2016-09-07" version="1">NQLWDLLPVLLSSATDFVQNFPHLAEILDKVLLEQQNLRLIVLSSLRSALRYALQPDGIEAKKEVMRFLAYSFLRKLFVLYTVSNVTMESLEGVTGNSLKTLRCSILETVRMYMNLTPINVIDNFINLAVEKTEIKEIVLDQKIRILDLMAALVKKASMSGLSKIFSVIHPWFISSEVALQKKAFRILEEIMKRMNDEAVVDFFSSSADEINNVLDQDLDNIAKSARAALIAVYYAKLSSLTSFKDIEIFEKKFLPRIIICLDKSHNIRTRSNALKCFVKLCQQLMFFGGDESKDSSSVLHPVMDMIFDMLNPEELSSSEDSLEIIRSSTIALNIIAQKFTRILDASQLSRLIAHACSWIGDGRPMIRVLIIRLLRMLAKKLPDYTMRQYQELLLSAVFDGQLTANVTQKVRKANKLLLEVLVDRYGAEILIARTNKLDWIKQLKAIAKIRLTILYYRRRQKHRNVKEVRNANIYEEQDHDVVSTAASARTAGADTILNMLCDSDSENEAETDHESIGGRTRGSSIWLKNDGDEDMMDLLDRNKVLKNIATTRSNLLEDKKSQELNNNDFKLAKDGRLIIENLDIDQQDKRKRKQLARLLDMPDKKLKKNSDSKNDSDSIHRNLCKSSTDTTSANEFSKRRGAGAISKKSKKYEPYIYVPINKRRVEKNELKTLIKGTKKGAIFDSKVKKMRRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2G1</accession>
    <name>A0A183I2G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13923</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040472">
        <property type="protein sequence ID" value="VDP15018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2G1"/>
    <dbReference type="WBParaSite" id="OFLC_0001392401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001392401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001392401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001392401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7803" checksum="86680D2C405192EB" modified="2016-09-07" version="1">MLQKNEKHLCAVVIAVVTTVVATLAYYCYKEGKWPFEKLPPSVPDHQNGANAARQLKELMFNESIKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2U4</accession>
    <name>A0A183I2U4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS14056</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01040567">
        <property type="protein sequence ID" value="VDP15383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2U4"/>
    <dbReference type="STRING" id="387005.A0A183I2U4"/>
    <dbReference type="WBParaSite" id="OFLC_0001406401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001406401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001406401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP15383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001406401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15527" checksum="03C690B07F900D2B" modified="2016-09-07" version="1">MMVLNPEQWVEPMKKAGASQFVFHVEALESDKVARCLLIELKVLVGVAIKPLTPIEKIATLVGVDMILVMTVEPGFGGQKFMADMMEKVRILRSTHPFLNIQVDGGVTLENVEVCAKAGANVIVSGTGILKTPNPAVAITKEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3K5</accession>
    <name>A0A183I3K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040761">
        <property type="protein sequence ID" value="VDP16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3K5"/>
    <dbReference type="STRING" id="387005.A0A183I3K5"/>
    <dbReference type="WBParaSite" id="OFLC_0001432501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001432501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001432501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001432501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8235" checksum="AACB1C9950757882" modified="2016-09-07" version="1">MVTSLFGASTLPVIQFEAPPSSTFSDHIPVSFTVTLSVNQPVIVTVNLLTADFRPHHLVITPQQSVVHIAESTTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3P3</accession>
    <name>A0A183I3P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14355</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040789">
        <property type="protein sequence ID" value="VDP16690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3P3"/>
    <dbReference type="WBParaSite" id="OFLC_0001436301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001436301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001436301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001436301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6205" checksum="28A36191A96778F9" modified="2016-09-07" version="1">MDGWMDGWMDGWMDGWIVVVMMEIAAAAKTLLSSPLRYEKCSVITTSQKVHSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I478</accession>
    <name>A0A183I478_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040940">
        <property type="protein sequence ID" value="VDP17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I478"/>
    <dbReference type="STRING" id="387005.A0A183I478"/>
    <dbReference type="WBParaSite" id="OFLC_0001454801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001454801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001454801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001454801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24135" checksum="162C7946339D9F5C" modified="2016-09-07" version="1">MTMVASSPLPLTTNMGCASCRQLHADIKDCVAQLSDKLDQLRVRVETLFALRQPGYGVDVAVSAEDDSTVERSIILKDEVISECGTEEKETPSPSLLENSDTTIGNAESEMIPTDNHNHALSGSRKRKPNREAVHKVEKINSNNNLLAQDLVSTQFCFRKTAALFDSFSLAANLMATGGANAAAQQNILSMLCQQPAAAHPPTSSTPNSTDDGLNDLVMEGRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4G2</accession>
    <name>A0A183I4G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDT1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14624</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041015">
        <property type="protein sequence ID" value="VDP17923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4G2"/>
    <dbReference type="STRING" id="387005.A0A183I4G2"/>
    <dbReference type="WBParaSite" id="OFLC_0001463201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001463201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001463201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001463201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="643" mass="70353" checksum="1307D1EA35E5CB6D" modified="2016-09-07" version="1">MIEKKRKISSDEETSDSKRTCILSPAKPPVDNSSSLMESVKGSSPLSPVRLSSSGAAPTAKPNDIPRNRFLTQQFIKKRRLLGQPPMAKIQSPAVKAAMGVKKKLKPQVKRTTVEMTDEDLAGFLKDMAGGEIEPVEEMENVISVAKEQICQKTTSTPIEHDTDVNKPVTPSEKIPQPQVASSSGLAAPSSTVVISKRSPGRPPGSTVQHKQLPIMSDKLRAMIDTYKQKTKEFGAPNKKIRLPPSLVDLCIRIEEQCTLECLNHQQKTRIFDLLANWVCVQRNSLYIRMKAHRDRHEPNATSDSDINADELMSETKEVPRSISSEKLSSSNDSSSSVIAISSPVVFDSSRRSPPETLTPEKKKEQLIGVKNTTSSDAARSSGAKHPPAAIKEGTEKMGTTPTTSDATFSSISTTKNRNSSGSSKPACDSSKAPLTTNVTSALNNPQLLSAFATMMQQTRGDSSSQQQRGVDNLTTQMNAQILNSKQQSELLSQYQLSLSNLVKINTTTPTSKLKNLALSKPTTSKNDPQSSKLLLKPNRSLSSTSSSSLSPTKVKGLKQTSNEKASRTLKEINNALAQVILVESLSKLWISYEIRTALKKQITALFTNLEQHGDSTHIVNTTIVQYLYYTVRPLFKDYVKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4I0</accession>
    <name>A0A183I4I0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxisomal assembly protein PEX3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14642</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PEX19.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041035">
        <property type="protein sequence ID" value="VDP18008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4I0"/>
    <dbReference type="STRING" id="387005.A0A183I4I0"/>
    <dbReference type="WBParaSite" id="OFLC_0001465301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001465301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001465301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP18008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001465301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24833" checksum="00F96F144EDFA741" modified="2016-09-07" version="1">MSGIWDFVKRHRGKIVAGAVVAGGAFVIQQTWRNPSLQFFSSRWNRDREFIRNQLKARRHYIYDTQHRTCDASILDLLPGIAKRIELYFDVEALIKDLKNNKELSKEQRIIQWQDIKVKAIGRMVAVAYAFSLITVILKCQISILASQLCSSLMEKEDNWWNHYLPENLKFSTSLMHITTSQKCTVNSSSQQIFMRCCQYFISTGKASSNLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5S8</accession>
    <name>A0A183I5S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041599">
        <property type="protein sequence ID" value="VDP20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5S8"/>
    <dbReference type="STRING" id="387005.A0A183I5S8"/>
    <dbReference type="WBParaSite" id="OFLC_0001510101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001510101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001510101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20541">
        <property type="entry name" value="CYCLIN_CNTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615:SF2">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001510101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30357" checksum="56AF07D4F48AC630" modified="2016-09-07" version="1">MDPDFLDKTACLPPDMYNDWLSVLAAENSRRINDANEWNHAFHTSRSAEYIFTACTRLRLPQEVKYSALLIFDNFMVQLVSRLHESVYNSKRSDRKKYQEWNRIEATLSRQTTLRMLSAIQIASKMHSYHESLSIKTVKLCLKTLGFAYTEESVVRSELRVLSMIDWEPSYHCTPLIYKRMMVNVMGPSANIVTREQMCRVQADWFLLACGVIVTAVCCVDGMQAADEVTNELHRLSNIPLADITDMSVAIIECVISQQGSTCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I742</accession>
    <name>A0A183I742_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042357">
        <property type="protein sequence ID" value="VDP22541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I742"/>
    <dbReference type="WBParaSite" id="OFLC_0001556701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001556701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001556701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001556701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39596" checksum="2209A7E487623702" modified="2016-09-07" version="1">RPITPNSSVPCYTLDNVTTTGNSDAFYENFAVKLSSAEMPAGANEGILSECFDDLKPVMSTLQSVLAVAEATANLKQEAAAVAEKKKELSSTLENGFETDGDSDMNCSDISACNGKISKEPCRSSSPSSPQASIVSAQEDGNLRSARLHSGCSSPSQEQQRLHDGPSRLPVFDGSNVVSSPCTSEAGLEADEIVHVHASCPVKSQEYHDAVNNVSSSTVILPHQSSSTSVPPIALGKTGNPVSFKSMISHPTRTSPYRLPVYSSVRFRARNMKKQQQQQQMNLTKTFQQVNSINNTNISDADWINDEEMLFARFVGIRLKKMNSHYRSMARMKIMQILDGCEEGMIDXXXXPGTNENYANIGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7F2</accession>
    <name>A0A183I7F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15664</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042576">
        <property type="protein sequence ID" value="VDP23138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7F2"/>
    <dbReference type="WBParaSite" id="OFLC_0001567701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001567701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001567701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001567701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9008" checksum="BCA10F2AC4EFB937" modified="2016-09-07" version="1">MVLDWGQEVLIFVGNLRECSYSREVVKSYVRAVFVGRVHQSNCHLYSELNCLYTTSPTNTYYVIDPSIIHDSIIHITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I808</accession>
    <name>A0A183I808_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apoptotic chromatin condensation inducer in the nucleus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043105">
        <property type="protein sequence ID" value="VDP24439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I808"/>
    <dbReference type="STRING" id="387005.A0A183I808"/>
    <dbReference type="WBParaSite" id="OFLC_0001588301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001588301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001588301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001588301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20904" checksum="3D16E378BE3366DD" modified="2016-09-07" version="1">MEEKERLRSTSSNSLNMVIHPNIPLKRMSTEEKTKKTKLDEQDEKKELKDGDYSFIVEDKSPSPSVEVRLPFPMKQQLDTSESPSEEERSISKSNSEECSEEKTTSISESKSSDTDKDGSSAPESITSSESDQKRNLAMPERLAGIVTVTVPSSPAPAVSTSISESKSSSEVVRNSTSPSSSTSIIRIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I818</accession>
    <name>A0A183I818_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043122">
        <property type="protein sequence ID" value="VDP24517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I818"/>
    <dbReference type="STRING" id="387005.A0A183I818"/>
    <dbReference type="WBParaSite" id="OFLC_0001589301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001589301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001589301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP24517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001589301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20315" checksum="735D43FF3AD2DCDB" modified="2016-09-07" version="1">MVKLIEKVKIDNLLYTIHPEGKLEFEINLGENASRLQNRDPDGLIHLLHDIVPRGSVLIFCPTKQNCEKVCKMISRLMPRYIREGKKTEKIAAIEAIKSEEDGKVSSLLELSIMNGVAYHHGGLTAEERKIIEEAFEVDGIINIICCTSTLAAGINLPVRRVIIKAPFVGKEPLRKAQYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I881</accession>
    <name>A0A183I881_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15943</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043325">
        <property type="protein sequence ID" value="VDP25207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I881"/>
    <dbReference type="STRING" id="387005.A0A183I881"/>
    <dbReference type="WBParaSite" id="OFLC_0001595601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001595601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001595601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP25207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001595601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18316" checksum="3107C61B3471E311" modified="2016-09-07" version="1">MNQEILDEDDIIPGQSWIACNMCCRSASISPSRIAFYLTRCGHIFCNKCLIDTTRICLYCKKKITICKISRNMPQKVRTYFRCPRELLAESMVEIMQVIRFQTMHAACLAKRFNIMRTNYEKLRRFCCEILQKKTTLERELMNKVGLSDHNNTSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8J9</accession>
    <name>A0A183I8J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043868">
        <property type="protein sequence ID" value="VDP26662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8J9"/>
    <dbReference type="WBParaSite" id="OFLC_0001607401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001607401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001607401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001607401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9854" checksum="78CA59E65627CE33" modified="2016-09-07" version="1">MFQILQDVCHRVQREITFQLGRLRGFGPATVNFRLSLVRILANKTSPLRFANRKGDCRVFLWKGRILTRNEYLKMNNISIDGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TW90</accession>
    <name>A0A3P7TW90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000191">
        <property type="protein sequence ID" value="VDO26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZ91"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="224" mass="25867" checksum="72C17D8EB1E2EDBF" modified="2026-01-28" version="1">MSLMLDHYLDSLSTLPCDLAKNLQGIRKYDMECHKRSAEIDRKLRTFTLFAEIERLSNEKIRLASDTYELVDKHIRRLDNDSVKLQATIRQKYLDAAAAAAAKANKNGDEMLDRKRKSVANRKDKKKLKEDHWSQKSAASASTSFQPFLDAPSVMEMPVDPNEPTYCICHQVSHGQMIMCDNKQCPIEWFHFQCVGLMEAPKGKWYCERCNEQRKKKNSFGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VYW5</accession>
    <name>A0A3P7VYW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008644">
        <property type="protein sequence ID" value="VDO53296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HKD4"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="104" mass="11446" checksum="149A88C823CF8AC9" modified="2026-01-28" version="1">MGVLSLKIEFSGGAESLFDMQKEFDIQVPNESGPLLVSDLIRYINVNLIPDKSRSHLLVDKDGENVRPGILVLVNEVDWELLQGPKTILEDGDVISFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X0L6</accession>
    <name>A0A3P7X0L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011300">
        <property type="protein sequence ID" value="VDO59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X0L6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="138" mass="15524" checksum="5CFA9FD4CC1FD5F9" modified="2019-02-13" version="1" fragment="single">MLGHFWGVYRGRNIDFTTDKAGGRQYTSFEGGRKEMEPRSPPKPLTPPPVEDVPIDVDTDDYKVDANEIICFSGRQHFLSNLYPVTLTVDGHDYPSVEHYYQACKLYTLGGARLAAQLRNIPDVGLIKAHTKKLLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XTH9</accession>
    <name>A0A3P7XTH9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11190</name>
        <name evidence="3" type="ORF">OFLC_LOCUS11639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015845">
        <property type="protein sequence ID" value="VDO74568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UZAJ01017065">
        <property type="protein sequence ID" value="VDO78046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XTH9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13234" checksum="35C3E1603CA0CEAA" modified="2019-02-13" version="1" fragment="single">MQNSFQIRLLREELKQARHKIAAQAADLEKAEIDADEAERSTRETIDELEEEVRSLQEKLKIVEIGEENQSKRLLIAEEEMMRSQEISEKYEKKCEMLTKDLEEVRGALADANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YGS8</accession>
    <name>A0A3P7YGS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003676">
        <property type="protein sequence ID" value="VDO40708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HB18"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="150" mass="17050" checksum="136410B2AFD2D75D" modified="2026-01-28" version="1">MSGRKRKMISDVPKKVAGNTNETKSIVFKNGPMSNDDFTDEFHSLPCRIEYDGPAKVSQYFVIDELGDDTKIATFRGHILNGVQQQFPDGYRLYIVVEKRNNDNNRVFEVSGSATSFMRWEYDRNANYQSPLVQAMGYLSIAGTFAKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AD64</accession>
    <name>A0A3P8AD64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039940">
        <property type="protein sequence ID" value="VDP12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZ94"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016615">
        <property type="entry name" value="Otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013503">
        <property type="entry name" value="Ubiquitin_thioesterase_Otubain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="283" mass="33030" checksum="928FB3C1B4F579A2" modified="2026-01-28" version="1">MSKLTEMKETVKSNEGNEVCSADQQLTMNGATLIEQINRQKKEIEDEVRKEQALVAQKESISVLLNEYDQDKSAEYYQKSKELAKVYSSLRRIRGDGCCFYRALLCAQLEYILNDSDELIRFTEVCKGWRQRLTKLGFPEFTTNDFCDWFDELLDDIAAAKYNENLLVEALNEEGRSNYYVTFFRLITSGYLRENAADYEGFIDGGRTMEQFCQSEIEPMFKDCDHLAIIALTKAIGVSIRIEYMDRTAAPHHGWFYDFVVNKELPKHFFLYRPGHYDIIYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B7I8</accession>
    <name>A0A3P8B7I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040096">
        <property type="protein sequence ID" value="VDP13210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0G2"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008048">
        <property type="term" value="F:calcium sensitive guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="191" mass="22108" checksum="B430CEDC718E766F" modified="2026-01-28" version="1">MGKPNSKLKRDQVRTLTKQTYFTEKEIKQWHKGFVRDCPNGMLTEAGFQKIYKQFFPQGDPSDFASFVFKVFDENKDGAIEFHEFIRALSITSRGNLDEKLHWAFRLYDLDNDGYITRDEMLSIVGSIYKMVGSTVKLPKEENTPEKRVDRIFKMMDKNNDSQLTLEEFKEGAKADPSIVHALSLYEGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F548</accession>
    <name>A0A3P8F548_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040855">
        <property type="protein sequence ID" value="VDP17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="96" mass="10662" checksum="BBD5D35698FB4691" modified="2026-01-28" version="1">MGTAISYCLIGEEEAHATHIPYPALSPKRTLDNIGILVSEGSSKIDPYNYSHNTAVSHDMKYFLANEMCTGTPQHYPKFTWNIRSDVIGEAICSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYU8</accession>
    <name>A0A183GYU8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS408</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="EMBL" id="UZAJ01000130">
        <property type="protein sequence ID" value="VDO25689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="501" mass="57325" checksum="351E6A7E0AA4D778" modified="2016-09-07" version="1">MDEVLLRNEDDSMLEYYPKLELIDRKLIKQLSDDAIDWAHAHGMVMRTAATADRSDICQTVPFTLFPSPFPHSLFQEAMNIQQAFNFLYFRVSWDFDFLIKSHAEVTKTDDFIRHFVEILNAVRTSSFCQKKTLLIQRNDYMCHEDNHGNRSLKQIEVNNIAASMGSHAERVTCIHRRTLETLGIPNKIIKMVIPDNHPTITIAKGIYEAWCDYGVPEAIILFVVEDVNQNQIDQRQVEYRIDELSSRNARCLRVTLTDGAKRLKLDETSHHLLLDNSLRVAIVYFRAGYLPDNYPTEIEWTTRRIIELSDAVKCPWIGLQLANTKKIQQVLSEKDVLEKYITDDNICARIRKTFVSLWGLESDDDKTLKIIQDAIAHPEKFVLKPQLEGGGGNYYGKDVAEKLKTMSRDEMAAHIIMERITPMVVKNYLIRPQEEPVLMDVVGELGIYAYLYGSPAVSNTPEEHIMKNYVSGHIIRSKGKNVDKGGIAVGAAVIDSPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZN9</accession>
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        </submittedName>
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        <name evidence="11" type="ORF">OFLC_LOCUS699</name>
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        <name type="scientific">Onchocerca flexuosa</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
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        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Myosin binding protein Ha"/>
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        <property type="entry name" value="Obscurin/Obscurin-like_Reg"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="2" id="KW-0787">Thick filament</keyword>
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            <begin position="488"/>
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            <begin position="1355"/>
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        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1575"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="2579" mass="291319" checksum="940E8CF8F0CD6860" modified="2016-09-07" version="1">MIRPSMTYTLSETETEVSSNVHITHAAESYDHYFSSIQPETFALGYSCLASTSKVHDDSVIITHESVQKAIEREQEVSEAYVNLNVNVERTPSLFKHDARILQSADESVTIFRREPRYTRAEEVIQTNDIFLISDQHILQYRQSVLNATATVVFEKPPQRALHEVTCLYDDKAHVSKENVQAVSTIDLQKVEIVNEFFNTIIAAEERFCEAYAEVNVDVRRPDALFDHFIMVVESEHEHLEVHLIAPVLVKNLATCDFHFQQKPESLQAESVHTDHPRRNAAAEQRIVILESSFQKFSEAITWSLKKVSKVATDSGMTAVHANIKIYKPEEIGEHATTIVDTRKIVPELFAIAAAASKFKLTSIFVTFTKKGDVAHQALVIEYESFVEDEATLNVATLTAPGFHSKQESVWSIGKKYEKAEGIEADVVAAFVEVNAICPNQNIELVASVSLPLSAPGITEITRSSKPLLELSSASLSESSSTGLFQAPKFVKTLENMTAIVGQFHQFKCIVSGTPAPRIRWYVDGDIIRDSDVYQTIYEDGVCILKIRELAIEDEGEYTCEAVNDAGRAITKCFLQTITEADVLKYQQQAIFKNILYSNSGSNTNNSSDNVAFLDNLKSFNNTDGVMYRNPAANCDDLAERDDNSRDYLVVNYEFDRTEPVSAETAVIVTRYTSSQKEFHKNFASEERSFNISVFLPDAAVECAFVWALINREKIELSLMPSFQTVDFVIQNFQPQQVQKADLLLNVKKLTIENVSFAICQPWEEILLVKKPENSFIWDSEYCRTQKAQVGIFTKSSNENGSSQNQSEKNIVMGSGCLSQSFDYFDLVGKDDTKSLTSQANSTLSMKGNVNISEKAKSEQNEEMVRFKNEQEESRIPILPQKITYQKQEVDILIKNDDNKFKYELSRQKFDDSETNTNVLSAIRKYVDELFDFDSVTAITCEQKDVSKPNTISNQIESGLDFADEVYLDCSFCRRSEHAEASENQNLSVSEMETLASSSSHLIENFSSSKNASLNLNPISKNMLSNEKSIESIAKVRSLACEANCDSNENSKQNLDNPVNKKLHSKLDTCNSFTTPDMEPHSDLSTETYPLHFTNSIASTNAAETFDASEEFEIFSASANPRLQHCESFSTPSHPSANNFHVLEAEHSKSPHISSETVNVSTSNTRISTKEPLSTHGSITDELSRTGVADKIRNKEIKNEIKIKSEDNEKAFQIECAIYDISEQIEKIERQQSLTEAQAEASEELLKTILENIIKNVGQNSVVETMVAYKKPVVLLREKLTDLEETLMREDLESRKSSESILEAQPIFSKSLNEEDLYAVRQSSIEREIRGTSLCALRQVGIIDKEEIRRMTPLTSNIKEQLQSLECMLEEVEKEEENDEEELTEETKVTIPVYSDDKRHEVHNILMQINNEISIIKRSCQRNISKTSVDAAIRLLHKVRNNVSSMIDLISVYRKRLKRKSPATNRERMKSSKRTSHHLFPTSRTGFFFKTDASVNFYLMKREESEIINAIVKLCSLSNKSGNQMSRSQDSEISTYEDALFDDKSMILQRTGINNAPWTAVLEPVAEKNDKVSLSNFGESQSNSFPPHSLQDSQEAIPIPPPRRLRGMSQQSFPPPIPPPRMKRRSKSYDNYKNLVLSRASDTQNSLSALQQNTTMNEKGKASISASDYSDPVNIKDLEDVEKSNLSIFQQNFKKINEINSERIIRKGESFYSCSYTWPSKVKYRISFEIFDESSPMQLLCEDSDYLPESLMHSFSLFEPTKRVQEENEGELLQTLELFSDLNTSKVETVVENAEKRRENFAKLKDEREAKNFHSIQKSTTPELDESYNQHISEYLTDVGQKINENSKMIENPRGSSSEDENFEDIQKPAQYLHASPNIKARGSILANPLEDEANSLHEIESIADRDEILDELDDLLVICNPHTDVIDVIDSLPTIMEDSENSKIADPFMSMSTNTVISVCISDTDIPGTSQDDQQVVVENRKQSDITTPTSESSLERKNLIAKTVNVPFRRSNKDGITYLDSYKKKIILICENDTKQVSEETTINIIYKSCPSKLKVLATLSPEVRAQVEACAVNGEDFDVLVEQPDEAQDFTVKLLDHISDSISLDLTLPNTVEVNLSLIRSEQYEGILSYQIGYLLDGETDEERINTTSDYKQHHHSSKTTEDRVRHTGISVNIVARSMHDVARASLEEIPWGEVSMYIVMQPLMTRSISDSGTRNSLIQNVTVSESNETEKRSLHSHESFRSSSRQSFDWTEFSDRSASWQNLNVPSYVVREGSTATITCEFNNFLAPGSLIDWFKGKTVMQIVPGKTDRISHDLLEVLVISHVSLMDGDVYSIRVNDVIYPVACLIVENIDTSSEKINSDIHFISPPQTLFVMEGQPSIISCQVNSANQKVEWCKDNKKWVAENERIRLEADQFGFHRIIIDKSELEDQGTYYAFLGDHFTTVTLVVEERIDEREVTISALGTETGEDDYREYLVPLGSTATIACELENSDEVQELVWRKNGAKIEFPDDAKLEHVVNGLKHYLVIHDTQADDSACYSICINDIEFKIANLIVSNCSTSIGSKHTKRISRNSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZW6</accession>
    <name>A0A183GZW6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAF3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS776</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000299">
        <property type="protein sequence ID" value="VDO27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZW6"/>
    <dbReference type="STRING" id="387005.A0A183GZW6"/>
    <dbReference type="WBParaSite" id="OFLC_0000077501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000077501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000077501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.50:FF:000001">
        <property type="entry name" value="TRAF3-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000077501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34631" checksum="A349B4FEC92A3883" modified="2016-09-07" version="1">MYTEKTKELFACLIDRPLLTDQLLQRPPFRFLHDIVKITIQNTGFLMNNFTNEEMDAATITDKTAKTSFLKKLIKALNDDGSLKDVKVAKIIAGKEPEMTNLMLQKLAIDAATYRDSKLKDTAKEEKQKKEKKAHKKEQNNKGVERKNNHNESRKVERDRRYSSKSKEKRKKESEYKTTIIKQTVGDNKRKDSINERHFKDIAPETLPTNTERMIHTDQEPTATTKMEDSVIVDKIINETEQPLISPTLKEQARLSTSSVRPRTSLSRLGTAAARPAPPKIKKKRVEEIERKPEIVSFSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H018</accession>
    <name>A0A183H018_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS829</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000330">
        <property type="protein sequence ID" value="VDO27248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H018"/>
    <dbReference type="WBParaSite" id="OFLC_0000082701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000082701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000082701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000082701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7902" checksum="9DA4FCAF66A4434D" modified="2016-09-07" version="1">MWMFNVIQSLTQQKPILSSKTRKAISGLPAPRRHQPVPFEFSKYVAISKILLYKIKFGPNLPKSPDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H063</accession>
    <name>A0A183H063_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20 21">Poly [ADP-ribose] polymerase</fullName>
            <ecNumber evidence="5 20">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">OFLC_LOCUS873</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 20">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="5 20"/>
    <dbReference type="EMBL" id="UZAJ01000352">
        <property type="protein sequence ID" value="VDO27406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H063"/>
    <dbReference type="STRING" id="387005.A0A183H063"/>
    <dbReference type="WBParaSite" id="OFLC_0000087201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000087201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000087201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:nucleotidyltransferase activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:double-strand break repair"/>
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    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
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        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
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        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Aha1"/>
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    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
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    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
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    <dbReference type="InterPro" id="IPR038650">
        <property type="entry name" value="PADR1_C_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008288">
        <property type="entry name" value="PARP"/>
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    <dbReference type="InterPro" id="IPR049296">
        <property type="entry name" value="PARP1-like_PADR1_N"/>
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    <dbReference type="InterPro" id="IPR012982">
        <property type="entry name" value="PARP1-like_PADR1_Zn_ribbon"/>
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        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
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    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
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        <property type="entry name" value="WGR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
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    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
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    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08063">
        <property type="entry name" value="Zn_ribbon_PADR1"/>
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    </dbReference>
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        <property type="entry name" value="NAD_ADPRT"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
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    </dbReference>
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        <property type="entry name" value="PADR1"/>
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        <property type="entry name" value="ADP-ribosylation"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
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        <location>
            <begin position="107"/>
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        </location>
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        <location>
            <begin position="652"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="VDO27406.1"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1015" mass="117300" checksum="8292D8F8107103C4" modified="2016-09-07" version="1">MASMGRDLSYGAEYAKSNRAACKGCHGLISQNSLRMSFRKPSRFFDGLQDNWFHFACFWKKIKQDHINEASIRGMELLKWSDQERIRKKIIENQAGVSCVEDLSVVLISEYAATGRSKCVNCKKNIKKNTLRLGMKSSWYHVNCFEKMRQYAICTEKIVGFQNLSESDQDLLKLMFNKQIKTTIKKKSAEINDAATKRAKMDQFDTEEKMKRLKAQANEMWSVREKLSKCLSKNDIQTLLQANHQALPKRGGESKLLDRLVDCMVFGCPLPCEHCKEGNIVYSSSERSYVCTGYISEYTRCMYTCRNPPRKPFVIPDEMKKIISEFQNFEVRDPKNREYSALEHEKLIEPEPSKILSRDVGEMSNEFMKHGNANLRDARSGIQRQIIKNGTVVDAECLLQEVVHVWKDEKGKLWETTLGKADFQTGANSFYKLQLLKHDFKQKYYLFRSWGRVGTDIGGSKTDKYNGDLEGAKIAFEKLFNEKTANNWNDVENFRKIPGKMSLIETDYRNSKDLQAFIGKPGSSSKLPESIQQIIKMIFDVDAMNDILKSLEIDTNKMPLGMLSMRHIKNAYKILTELQKLMEVDNAKYEDYLDATNRFFTLIPHNFGMNKPPLLNSQKRLIDKTKLLDDLLELEVTYSILKTDDEAYRKRDPVDVHYEKLHAQLEILDKQSDEYKRILQYAANTHAPTHDQYRLEIIDIIRVKREGESERFKKNIPNHYLLWHGSRITNYAGILSQGLRVAPSEAPVTGYMFGKGIYFADLISKSANYCYAVNTEGFILLCEVALGEIQEEINAKSIIKPDRGKHSVKGLGQTIPDPCEYFITEDGVTIPMGKPVDTKRRDLTLLYNEYIVYDVAQVEIKYLVHWDVIFTALQRFQSILENWLGGSVSVLCLQVLLRVLYFRSCFTGLHSFTAMAKWGEGDPRWIVEERPDAINVNNWHWTEKNATPWSKQRLKELLEGQKYENGSTVIMFKELKKLDGEATANNRKAKLIFLFEWIIELSFEGLFFSTLNKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H069</accession>
    <name>A0A183H069_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxide-inducible transcript 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000357">
        <property type="protein sequence ID" value="VDO27432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H069"/>
    <dbReference type="WBParaSite" id="OFLC_0000087801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000087801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000087801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000087801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20762" checksum="C69B5E2B3942037A" modified="2016-09-07" version="1">MMKEIKGAEVRATVEQALSIFEKLSLKADDSRDSEDDGDSRIPRISKKSFKTIYFCQKTQQPSTASGYTARLSRDRTRHRYKPYLLPLMSKKVDTLKRNSVLEKLWNIKLEGDVDDLRLTLSEQPSITERSKSSSCSVEASRCSPWDLADEGVDGEVAELAEYFNQFVNICLKMSALAESMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H085</accession>
    <name>A0A183H085_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS895</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000364">
        <property type="protein sequence ID" value="VDO27485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H085"/>
    <dbReference type="STRING" id="387005.A0A183H085"/>
    <dbReference type="WBParaSite" id="OFLC_0000089401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000089401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000089401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052324">
        <property type="entry name" value="NFATC2-Int_DNA_Repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47187">
        <property type="entry name" value="NFATC2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47187:SF1">
        <property type="entry name" value="NFATC2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000089401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36075" checksum="43C5BB2F326A8CF4" modified="2016-09-07" version="1">MSQGEDTLGDDEDDYFDNPLKHLLSKVTSTRKSRNQTGTTTKDISKGESTKKDTSRRKTNVLDDLNNDGDDLLTLKGKRKVKEDSVLSKVEQEIKELEIFSNISAFPSSSLNPLTSSPTKNHSKRKRKVTDDNNSKSSANPIIIDGGTVEADDNIFAKEVFVVEPHCSIEIGDLEKCDICIKRWKMSETFTNIVKIYASNWSCSPDNVILSLRNGKRISAEDTPCSVAFSEKDVNYLSVYKNGSQKANKITVKWLLPERNKPIITAVPKDIPFIILKRDFAVDNGLDEEKLTLVFDSERINLQETVSTLGIEDGDCIDVYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V4</accession>
    <name>A0A183H0V4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1114</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000478">
        <property type="protein sequence ID" value="VDO28295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V4"/>
    <dbReference type="WBParaSite" id="OFLC_0000111301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8451" checksum="FE7A4FCBBA526FDA" modified="2016-09-07" version="1">MVIVTMMMMTMMTMMMMMMTTMMMMAMMMTMMMMEIWKIVMEMKFSWGSQIFRSFIHKPIFKFLEFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Y3</accession>
    <name>A0A183H0Y3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS1143</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01000498">
        <property type="protein sequence ID" value="VDO28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Y3"/>
    <dbReference type="STRING" id="387005.A0A183H0Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000114201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000114201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000114201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF30">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000114201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27787" checksum="2294A66E5F6EA4CD" modified="2016-09-07" version="1">MEETEFNGLSMQRVTKTDFDGIKKFLLTDFLYNEPLNRSVNLSAEDSDELFNELVDVGIASSLSYILQTPDGKIVALRLASILDRPAEEHPSEHIDESTWNKIGAKNNNDRMAKKTKRLSPKAQIIANILQELESKACEFIWILINPRLKRLLLWSVISVHKDYTRSGLAKKLLCYKLHEAKQMGCQGCISEASSFKSQLLFKKLGYETIHELKHGDWLDDRGQQIFQCDDSTNSIHLVFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1B2</accession>
    <name>A0A183H1B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1272</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000572">
        <property type="protein sequence ID" value="VDO28919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1B2"/>
    <dbReference type="WBParaSite" id="OFLC_0000127101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000127101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000127101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000127101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15177" checksum="1A3B9CD5D04DC304" modified="2016-09-07" version="1">MAATATSRSSREVEESIDMKYTKCKPFPYFFAQSSSSCAKQLETEEQSGIFLPQQYLHSSIIAYYNILVEWELFTHLMQCIMHFTTGNFDLLSDGQQNPEIDHNLLDCLWYILCLRYHLYLYERLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1C5</accession>
    <name>A0A183H1C5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1285</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000581">
        <property type="protein sequence ID" value="VDO28969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1C5"/>
    <dbReference type="STRING" id="387005.A0A183H1C5"/>
    <dbReference type="WBParaSite" id="OFLC_0000128401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000128401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000128401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO28969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000128401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26963" checksum="96EF72CD1E914EB5" modified="2016-09-07" version="1">MITQLRSWVTWSWTYLWALWFLLVIALVYILRGPLHITESLESVSIYFNNLTPKFYVALTGTSSLVSGIILIFEWWYFKKSFYIIKYLESPVTSVLIYSNAGDNGTGSEDDSDNEDGLDSASRNVPECKVWRNPTALFRGAEYQRFTKMTGKEPLTYYDMNLSAQDHQNFFTCEGDVGKQDYEIMQVAWRERDSYSRINAAYKALEINPECAPALILLAEEQCQTIADVEQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1M4</accession>
    <name>A0A183H1M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Legume-like lectin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1384</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000638">
        <property type="protein sequence ID" value="VDO29336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1M4"/>
    <dbReference type="STRING" id="387005.A0A183H1M4"/>
    <dbReference type="WBParaSite" id="OFLC_0000138301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000138301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000138301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552337" evidence="7">
        <location>
            <begin position="23"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO29336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000138301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58852" checksum="E7FB06BEA8368FAB" modified="2016-09-07" version="1">MWTLLSFLSLITIHRLSLLTQATDGPVQRRFEYKHSFRAPDLCLNDGSIPFWTIVGDAVATKEQLRLAPSMRSRKGLAWNKRVMAESDHFEIQIAFRVTGQGRIGADGIAVWYTAQQPTIGPVFGANDYWTGMGLFLDSFDNDAQKNNPFVALMINDGTRQYDHQTDGSQQMLSGMYSLELQFDFWGTIKVTSCQKDFRNKPYPVRLKIEYLHNVLTVSLSDGLQATPRYELCIRSENIFLPKNGFFGISAATGGLADDHDIIEYSVFSLYTDRAPVASALPQEEKQKYDAEFERQMKEYEKERQKFKEEHPEKVKPDTLEEEIAEIYEDASQRELRMIFEMQTNIHLILQNLESRLQNIGQQQNVQSALIQQCATKAGGGASDKPGEVAVGAGGFQQHEKNEVLQILRDLTSSARDMKSYMNEIFTRTYNLEQKMGSGNAVAPPSGITPDPTLRSLVETIQNDVRQIRTTQLGTPSAQVGGNCPNVACLSSSFFMTIILAQSAIMILVIWMKSKPEKAKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H207</accession>
    <name>A0A183H207_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1517</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000728">
        <property type="protein sequence ID" value="VDO29828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H207"/>
    <dbReference type="STRING" id="387005.A0A183H207"/>
    <dbReference type="WBParaSite" id="OFLC_0000151601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000151601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000151601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000151601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25989" checksum="C26C9EA120256EE3" modified="2016-09-07" version="1">MPYLGYCAVPDDQPCSSSDELTLINKNSELRQSGNGRSQANLDSKNNPMHCPRSFMKNVFHAEYSSIRRTVPLNERSIDVISLNGSERGVDILSPIHSLPPRPPSRSNSIGRFSQNRPPPPTYQSKNCIKQPAVSNKPPPPPPYKSRVMVRLSENLRKTPTKQITEFSPKATSTPKLEHSESEPCSEDERSTVCDRTERNEKTRSIYENVDHSDISVKAEIGTVWYEYGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2D5</accession>
    <name>A0A183H2D5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1645</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000818">
        <property type="protein sequence ID" value="VDO30287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2D5"/>
    <dbReference type="WBParaSite" id="OFLC_0000164401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000164401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000164401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000164401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="13855" checksum="2F114574F1B0C56B" modified="2016-09-07" version="1">MTTTYSVHPPGATATRGFLSHHSHSPHLQHRLHQASSFDSIRPTATIISPSSVQRIINGTDSSTVTAIPPATIGIIPPPPPPFDTTAAPNPAIAALNGTICRPSSSDCGGSSSGLGGMTKTDIISSDESSLASRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2X4</accession>
    <name>A0A183H2X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1834</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000945">
        <property type="protein sequence ID" value="VDO30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2X4"/>
    <dbReference type="STRING" id="387005.A0A183H2X4"/>
    <dbReference type="WBParaSite" id="OFLC_0000183301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000183301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000183301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000183301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19253" checksum="1681CBB5F659EDC4" modified="2016-09-07" version="1">MYSKTFRLTIGVMFDAEHNTAPHISDVVAAIFFLSTIGPDSLFRMILCKPSSERTLQELEHVYRELLHVKALTHLSTMVKRELAAVVFFEQHQHAGHILFRQGDEGNCWYIVLKGSVDVIIHGKGVVCTLREGDDFGKLALVNDAPRAATVALREDKSQFLRIDKNDFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H307</accession>
    <name>A0A183H307_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000973">
        <property type="protein sequence ID" value="VDO31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H307"/>
    <dbReference type="WBParaSite" id="OFLC_0000186601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000186601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000186601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552350" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000186601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26880" checksum="D8E88C2AC756390C" modified="2016-09-07" version="1">MRLLLCCIILIIIGRNAMMCYICHVYSQDLNKLRKEGDSVPKSVLLVRKFSYNFIIFEYLNHQATSCSFCFGIIRLNMFITGCRRQNGTESKTLNEFYGLSFYIVNIFHHFLIRVMCSRNPTYCGPNLCCCASTSCYDELRNHFLQGLLRSKKDIICDVYRQQWIGNRRKRLNISLYPTSEQLYRRIACDACASRVDEKGVEMICIEKDIEIACRGMNVFVGDDIACNGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H310</accession>
    <name>A0A183H310_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1869</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000974">
        <property type="protein sequence ID" value="VDO31067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H310"/>
    <dbReference type="STRING" id="387005.A0A183H310"/>
    <dbReference type="WBParaSite" id="OFLC_0000186901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000186901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000186901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000004">
        <property type="entry name" value="Peptide methionine sulfoxide reductase A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000186901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24305" checksum="F0365392761FE407" modified="2016-09-07" version="1">MTNLQKAYLGMQCFWGAESTFAKLDGVLATRVGYAGGTTQAPNYRNIGDHTEITEVQFDEKIISYDKILDYFWEHHDPTLEYKKQYKSAILYIDDQQKETAKKSFKKLQEKYGNRKLNTYVQKLIRFYQAEDYHQKYWLRCQTAIFNKLNLNNEEVVSSVLATKVNAFLAGYENFDVLKQLADQYRLDDDVVKLIESIAITGGYGSACHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H343</accession>
    <name>A0A183H343_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1903</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001002">
        <property type="protein sequence ID" value="VDO31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H343"/>
    <dbReference type="WBParaSite" id="OFLC_0000190201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000190201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000190201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000190201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10961" checksum="B379231CB42DEAF7" modified="2016-09-07" version="1">MRKSGEEINEYHILNDLDHFPRCNLWDVSPDHLIHNYFSANWIRPCEAWKRGRIQSVKGRVSILFCIFYHPPSKAKSFSTVSSRGPECPSNSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3A9</accession>
    <name>A0A183H3A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EIF2A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1969</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001048">
        <property type="protein sequence ID" value="VDO31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3A9"/>
    <dbReference type="STRING" id="387005.A0A183H3A9"/>
    <dbReference type="WBParaSite" id="OFLC_0000196801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000196801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000196801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="6">
        <location>
            <begin position="256"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000196801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66807" checksum="364E4A160EE0F7C3" modified="2016-09-07" version="1">GDLWSWLQNEKCYDQFAVHYERDAHGSKYGSVSPFVGVYEYRKGQDPVPITERHYWTETVFRWSPSGTFFVSVHRMGVALWAGANFERFSRYSHENVVMLDFSPCERFLVTYSLPENRWADDTNCLRIFDTMTGEMRRGFSLLSQEGSNELPCWPYFQWSADTRTLGSDETYLTCLEANGFVACPKPGGNGINVYETKNFTLLDKKHVIIEGLRTFRWSPTRPILAYYCDERTSDNAPAEIGLLEIPSKKKLRAQRIFSVSEAELFWNKNGDRLAVHTERYQKKNIKTSASGAIEEIKYTNPTSHIEIFDARGKDISVLSMPLSESFIAFDWEPSGDKFCVLVGSQHKSTPFIYYLDTTKHAPQLISKFEPMERFSDVLWAPAGGWLVVFSAGTASGNIMFIDSNGTRPTRTNLVEYPGFNKGSWDPTGRYFTAACTIGGGKGDTGYRIYTFQGRELYRKPLDRLMQFKWRPRLPVKLPDEIIKMIRKNLKTTSAKFEEEDKMERGKATKEVSEKRKKIMADFVQIRNICMKKLAEEAELRLQLRGGLDMLKADNEDLVEETITVPLTTEKVKLQEVTIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3B0</accession>
    <name>A0A183H3B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001049">
        <property type="protein sequence ID" value="VDO31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3B0"/>
    <dbReference type="WBParaSite" id="OFLC_0000196901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000196901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000196901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000196901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19214" checksum="E268B4E7143E8339" modified="2016-09-07" version="1">MAEYCCCDTDSCNGATTITTTKFEKKNQCLYDCEDDNLKLPDSRHSYKGLCEILNEYKIETEDLKECLWKFQLRFHSVQYSAQICITLCSYFFASFLMLIEPLEVITNQGIWEVYGDKMDDKLIGLIISVDLQVILPRQHSPNRNTIAVPLLIISTKNNDVMNHPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3W4</accession>
    <name>A0A183H3W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate-gated chloride channel subunit beta family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2173</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001193">
        <property type="protein sequence ID" value="VDO32105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3W4"/>
    <dbReference type="STRING" id="387005.A0A183H3W4"/>
    <dbReference type="WBParaSite" id="OFLC_0000217301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000217301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000217301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000084">
        <property type="entry name" value="Glutamate-gated chloride channel subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="262"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO32105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000217301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51337" checksum="071E830A1F12E070" modified="2016-09-07" version="1">MESMKHGTSTALSFDNSQKMRGSSEEQLILEKLLKDYDQRVRPPPTNSSATTGPVIVKVNIMLRMLSKIDVVNMEYSMQITFRERWLDRRLAYENMHVTNMPNFLTVPYVKNSIWIPDSFFPTEKAAHRHHIDTENMFLRIYPNGQILYSVRLSLTLSCPMYLQLYPLDVQYCDFDLISYAHTVTDIVYEWEKEGGPPVQRKPGVGSDLPNFLLTSIETNHECTSHTNTGRINEVRNTCLFYICMLEFLIKKPNQNYYLIQLYGPTTMIVIVSWVSFWIDMHSTAGRIALGVTTLLTMTTLTSSINAKLPPVSYVKVVDIWLGACQAFVFGALLEYAFVSYKDNCLQEKKNSMIRKRNRRIDKRNIENQPIYQQQCTCHLLSMHPRERTVDRMKRFFMRPTYFPAKIDFYARFCVPIAFILFNIIYWTACFVMTSGYGPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4X9</accession>
    <name>A0A183H4X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuferricin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2539</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001479">
        <property type="protein sequence ID" value="VDO33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4X9"/>
    <dbReference type="STRING" id="387005.A0A183H4X9"/>
    <dbReference type="WBParaSite" id="OFLC_0000253801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000253801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000253801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000253801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40562" checksum="8043DE35B855F496" modified="2016-09-07" version="1">MVNQQSLRSERSVSSARRRLYYPRPQLQTSALVYCALQVVITAFLFSYNGLSAGDVLLPALSWISEHSRKLPLVESIIDSVRRFLQNILSSIIDKNNIKTSTSSTKKSRMKQKVDTNSIIFMEKVDASLPVLTKEQLSFFDGTRPSKGTYLAILGRIYDVQKGAKHYGPGGSYHFFAGRDATRAFVSGDFSEKGLVDDIENLGDQDLLGIFDWIKFYEKDYDLVGYLQGTYYDASGKPTSRLKEVIKLIKNALHWKNTQLEETKVFPPCNSEWQKNIGGRVWCTKKSGGIEREWAGVPRKLFDARSKSYRCACVKNFGSPLSNFPGMDKNSENGDLENPNLEEYKDCKPTSTTCRNENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5E0</accession>
    <name>A0A183H5E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DC_STAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2700</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001610">
        <property type="protein sequence ID" value="VDO33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5E0"/>
    <dbReference type="STRING" id="387005.A0A183H5E0"/>
    <dbReference type="WBParaSite" id="OFLC_0000269901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000269901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000269901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="252"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000269901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="66379" checksum="6FC3A218FB585250" modified="2016-09-07" version="1">MNTTHNLQMLAESVACVSDSAIQVGNKLIGEVNRQTNKFSLSGLKEVMHFFGKHLKNFRDIMRKLQNTVVKFGKQTKDFLVQLLAVKEYCQRFFIGPYYFCLRIFDEGAQHCDRLTLYRGLTPCKFVKDMRKICEAARFSEMVCVIPDKITRTLKAGFLPFAKNKMKTAMNVVMNDYNISFIVKEAKVAKKTWEELGISVNYTVESNRTKMFELEKMKEELEKILNQFKVFVDILSIMIKFIIPNMRKEKADNVYITEEFRNIDMIREAQGQPSLLPLLPKERKIYIEGFTLHMTSKEKMRMLFAFAITLITGFLPTFLILLDIFTYQMLYFTYSFLQSNSTRTDRLDFYNLKAAGEGFVAKLLQKILTIFHPITGSQFSDDDWRQCFIEPNPPDFQLIRFMMLLYLIALLLCIIQVYAARFRHLIAQYYWPERTKPRTLWLYNKVLEGRKNILTQLVKAAKEKEVKDQLVEDEYSGRGNLANRGLTVLDADQYRCTRCFRPDLSITDASNTRICPNCNNLYCTDCYAVKKKCLECGASLQSVLDETEFYMDSSCEEDEPVQDETSVQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5W5</accession>
    <name>A0A183H5W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2876</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001769">
        <property type="protein sequence ID" value="VDO34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5W5"/>
    <dbReference type="WBParaSite" id="OFLC_0000287501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000287501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000287501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000287501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9756" checksum="6AAED86C107C126E" modified="2016-09-07" version="1">MLQLDLGTPSLSYFPSSLFLLNSNGRGKRKRNRYDIESSIHKWVHGPCHVNYSFETNRDETRCPYNYQHHFHCRCHHQQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7F5</accession>
    <name>A0A183H7F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3417</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002273">
        <property type="protein sequence ID" value="VDO36429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7F5"/>
    <dbReference type="STRING" id="387005.A0A183H7F5"/>
    <dbReference type="WBParaSite" id="OFLC_0000341601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000341601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000341601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000341601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22669" checksum="6EDA580E55270C8F" modified="2016-09-07" version="1">ENSIVISPGANLETSPSRIDELEKVVASAKLVLCQNETAYESVKRIFELARKHNVQTFLNFAPVEETFGNNILKLTDILCANEIEAEYLTDQHIGSIEDAQKAAKKLLEIGPLIVILTLGEKGAVYDSKHGDSSYITVPKVEVVETTGAGDSFCGAFAYFHVKRSELELKEQIRRAAYIATLSVQRKGTRDSYLPPKDLPPNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H810</accession>
    <name>A0A183H810_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3622</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002488">
        <property type="protein sequence ID" value="VDO37192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H810"/>
    <dbReference type="STRING" id="387005.A0A183H810"/>
    <dbReference type="WBParaSite" id="OFLC_0000362101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000362101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000362101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO37192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000362101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24652" checksum="CC3384B4998F8AC3" modified="2016-09-07" version="1">MLLLIEPPGTNKHHEVTGSVTQSGQHLLEYTSPEDDEEPDNDNVIASTTVGIGAFCGQKMDQFLVGKSNSYEFSERWKHEFSERPSWYDADMALQQIKRGKARGNRAALYSRSLIQKALFTLGTFVHHHTCLVLFTVVMFFIFCCYGLQYVRIETDIVKLWVARGGRLEEELNFLSRIEKLSSDKADGETGLGGAYQVLSCFYPHNFIFIFFYQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H844</accession>
    <name>A0A183H844_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3655</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002525">
        <property type="protein sequence ID" value="VDO37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H844"/>
    <dbReference type="STRING" id="387005.A0A183H844"/>
    <dbReference type="WBParaSite" id="OFLC_0000365501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000365501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000365501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000365501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18651" checksum="ABFAE2D2B5B548D7" modified="2016-09-07" version="1">IVGLPADSTIIRTRAIASNGLNPVWNEKFSFKVYCPEIALLRLYVEDGDFMGPKMDPFIGQAVYPLDCIRTGFRSVTLRNQYSEELELSSLLVYLDMRRQNNEAEVLNPHIALQAGRCLSGGLQKTSASPGIFSARLNSTDQNDFTPPLSPILSASNHVPIPMDLAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8P1</accession>
    <name>A0A183H8P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA ligase (ATP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002719">
        <property type="protein sequence ID" value="VDO37985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8P1"/>
    <dbReference type="WBParaSite" id="OFLC_0000385201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000385201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000385201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000385201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42592" checksum="8519FB54B6DA6554" modified="2016-09-07" version="1">MAICRLFDVKEEEINDLSEFLKSCLYNHVAVTKQANNDILLTVIDDDDDIDEFENLSFIDIPTQKSLPSESFVVKNGTFSPNQYRNESQDRPIDPTTSANVGTTAKSSLPDSEFARLTANDRFEYWKGSTLASAKIRSKDDCLPYKVLGDKILSFVRAKGSLKVSDLSEIFFEEDGRYIDPKNYKEGTWENIIKKLLSAGGHPELVVRDGILDLDRKDFQKFVSPPTYSSNNSDNTKNENGRSASLTVPAVIIYDLLMESGRPLLLKELVEKLSSKGIKVNACQLTVKLITEFKDFFCCEFHSTGTLISLLHGAKRPEEPAKSSCLSSFTESVKIVTHVMSDYCSTIESPSNIFKPVSFFWIYTSFLYDMQFEKPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H977</accession>
    <name>A0A183H977_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4039</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002917">
        <property type="protein sequence ID" value="VDO38675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H977"/>
    <dbReference type="STRING" id="387005.A0A183H977"/>
    <dbReference type="WBParaSite" id="OFLC_0000403801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000403801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000403801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000403801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17423" checksum="821E4B6E834C691D" modified="2016-09-07" version="1">MRYNKWTHEKTISPVLLVKMITVMETMNEKERKPIVVHGSQGIRRTAVFVITSLLIRQVRPSGLIIYVTFSRKQESIAKTRRMSVLKAAMAVCRRRYGVLRFVADYRLALQSALCYAKECDLIKNEKTFMDAINVSESPSCNRFANETIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9M4</accession>
    <name>A0A183H9M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 18 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4187</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003083">
        <property type="protein sequence ID" value="VDO39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9M4"/>
    <dbReference type="STRING" id="387005.A0A183H9M4"/>
    <dbReference type="WBParaSite" id="OFLC_0000418501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000418501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000418501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="5">
        <location>
            <begin position="13"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000418501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="72044" checksum="068745FF30C995F3" modified="2016-09-07" version="1">MYEIILPIWALFVCFPGRLYCLSGQINMKHDVTGIQPVVSTIWSSAFAEHSPAILQPLFASKAPLRYHSMDDGQRTLPSTFVVYPKVNNEQPITFCWVGADGYTLGRIDLTVSEPYDMIVEEAHVQHQLMDGRYNYPLDVALTEYHVLLLYSNHIEAVSLLNQKLMFDDIIGTDSGQVKGMCRDAVSEMVWVYTDITVWKYRPNEEFRDIWQIYLERGEYDKARTITNKLSNPAPHQLVVKKEAEKYIEEKNFTAAAEVLIESTDPFEVILLKFLSAKEDRRSGLKRFLELKLKSLSNAEDKIRRDILVLWLLEVQLTEFAELRRNGRRMQLEGTDLASEQTTFEQQIKNMRQQIEQFLTHSTVLAAVEVNRDAVYRLITSHAHFDIQLYLAQKLKDYATIVNVYLLQSDYEKVLEIIRKQNILELYYKHSPMLIEKIPTELIAAWIDEGKALVSDRLLPALYRCQDVSKTKMVTAALKYLSFVINENWASQAMHNFMITLCAEFKPEELLNYFEKYGYDRNLIPYDVEYALRVCIEKQALKRCCVFLYCVDELYDEAVSLALTVPVFEIDVELAKTCAKQMVKSNENEYDFLPPNSTKPKFSVDMRRKVWLQIGISYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAC6</accession>
    <name>A0A183HAC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003374">
        <property type="protein sequence ID" value="VDO40012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000443701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000443701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000443701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000443701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9062" checksum="7305DD3303E7DC23" modified="2016-09-07" version="1">MVKCGHGRRAGKRLETEHCRTTREWHESKNASVRCSSDDPTRRFGCGYFIDIVDASDSSYHPDAACPTDPCHSDTQFTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW3</accession>
    <name>A0A183HAW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003608">
        <property type="protein sequence ID" value="VDO40549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW3"/>
    <dbReference type="STRING" id="387005.A0A183HAW3"/>
    <dbReference type="WBParaSite" id="OFLC_0000462401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9834" checksum="A4E09D82019C3947" modified="2016-09-07" version="1">MHNVNNVEELAHHKYQVLEDCLYYKLSQDANKMQGKANAISILPPTVAAGETLDTEILEIALKQLWMNEIWHVMNINGHFLIMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA5</accession>
    <name>A0A183HBA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AF-4_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4766</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003792">
        <property type="protein sequence ID" value="VDO40980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA5"/>
    <dbReference type="STRING" id="387005.A0A183HBA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000476601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="2">
        <location>
            <begin position="214"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44146" checksum="7CE55F3B250CAC12" modified="2016-09-07" version="1">MIKVIKVTVSRRLKFQKFIKQCDKTYVTASATSNIKESERRNKRDGSTPTNCGSEQLPSTSKLGKKSLQPKSASHVSNDELADVLKGKDKKGCLDNEHSREKEKSAASRRKDCNGLNDQQVNSGIATTQLHEVKKKHMNDAAVSTVNNDNMRVKIAKNSKYKDAETPAKKCKKDTNVENKFADEMQEVDGDFICCRSHTAPAKKAVLEKNDDGSYKCANYYLDEVARPLKHRADKENGDHVRKTLAYMDAAVYFILSSATERENRQRQYMIARDSAELMKTIIKWSGASAASLSPLERHFISRFRMLSFRVQAVLNYYLYSLKMGSCMSNFGALTKWELQLTELDAAAVRNDGAASVNSQGGSSANTETPSPASSTNSGHLERQKEVSPLLEHQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBB2</accession>
    <name>A0A183HBB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4773</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003799">
        <property type="protein sequence ID" value="VDO40999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBB2"/>
    <dbReference type="STRING" id="387005.A0A183HBB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000477301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000477301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000477301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000477301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15072" checksum="D31C919B13145789" modified="2016-09-07" version="1">MLSTLMKCSCKLTTKSPKLVFFQPIRSRFGLNKKEKYRRRIDEFKENIEQSKQKLPYQEDVIPLRPLRDLYKAFGFTVGVGVISFAVAAIFDLKRSNNRYVLNFLRFLFFLHVQQKIFFILNVVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBT9</accession>
    <name>A0A183HBT9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4951</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004027">
        <property type="protein sequence ID" value="VDO41567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBT9"/>
    <dbReference type="STRING" id="387005.A0A183HBT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000495001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000495001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000495001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO41567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000495001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18632" checksum="387C7E72D27DC9C9" modified="2016-09-07" version="1">MKSEDDAIKDCTDRLPRTLVIRNFDIFCSIFSAASYLADIGSDILAAYIHYCEHRVDRRLKIQIWAFIFVTILTVLPSLLLNVVSFLWWIDDVSPYAVQREMKHSKQLIFRIVICLLQISPVVWYVEAILAAIKFRMAGKRNEKLSSYMAMIQAERDAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCS1</accession>
    <name>A0A183HCS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5284</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004463">
        <property type="protein sequence ID" value="VDO42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCS1"/>
    <dbReference type="STRING" id="387005.A0A183HCS1"/>
    <dbReference type="WBParaSite" id="OFLC_0000528201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000528201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000528201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000528201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20184" checksum="087C76486BE3092D" modified="2016-09-07" version="1">MSCSAIYILDLKGKVIISRNYRGDIDMSIIDKFMPLLLEREEEGRQIVSTSRKNVNVALVLTFLYKIVEVFGDYLKDVEEESIRDNFVIIYELLDEMMDFGYPQTTEGKILQEFITQEGHKLEIAPRPPMAVTNAVSWRSEGLKYRKNEVFLDVIESVNLLANANGVVLQSEIVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDN0</accession>
    <name>A0A183HDN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHR-BD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5591</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004881">
        <property type="protein sequence ID" value="VDO43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDN0"/>
    <dbReference type="STRING" id="387005.A0A183HDN0"/>
    <dbReference type="WBParaSite" id="OFLC_0000559101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000559101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000559101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000559101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45725" checksum="4AA50E30EA592966" modified="2016-09-07" version="1">MICVKRDDVKYWSCPFRIDLISSFHVTMRDVDETPQFLRVEVILNSAIFYVTFTDVRHYPPPIQLENLSDVPVLYQQKIERSQSSHLRTICKARSTVDYAWDDHYAEKLLILQVFENKSNFYDPQKPGMGPPLVKPEDGFTDELELALEVLHKGKVILNKLNPSDSSRNQLWRFAQDGCLENIGMNNRAKMGERYVLDVLDNGGFVLMMLKRNSARDRFQKWQFTSKKQLRCMVEGMFVEARKTEVVLAIPNKKSKLNKKGIPLEQIWELQSQLPGSGILDVECFHRGPTLVVRITDREKPYQAHAVHHSGELFHLQSPSGACETNFNSVWNFEVNVSMRNGIGLSFINGLHEELIYARFQGIVLHVNRQGSTYQITGSVEVIQVRFILRQMQISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFC9</accession>
    <name>A0A183HFC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6191</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005750">
        <property type="protein sequence ID" value="VDO45730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFC9"/>
    <dbReference type="STRING" id="387005.A0A183HFC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000619001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000619001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000619001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF604">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000619001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24216" checksum="D0F30366DB4ECBE8" modified="2016-09-07" version="1">MSNDYDTFFLDGRNFCMPTPDSIYPYQKRLKFLKRALQHLLVDDIFIELTDNKLGQGAVGFVFKGYVYPRKRSKLQRVFAAVKMSYPMPQKSIGLLEEAYRMSKLDHPNIVKLIAVSKLSFQAFRPMIAIEWLPGGSLVEYFREHIRKNERPPLIYVRDIINILRQIGNALKYLHESHDSAGNEVSHGDVAARNVLLTEANLRFFFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFF6</accession>
    <name>A0A183HFF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6215</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005782">
        <property type="protein sequence ID" value="VDO45807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFF6"/>
    <dbReference type="STRING" id="387005.A0A183HFF6"/>
    <dbReference type="WBParaSite" id="OFLC_0000621701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000621701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000621701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000621701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9587" checksum="22EA3735CE88AAF2" modified="2016-09-07" version="1">MQKSVQVAKVGRKGFNGRKALADMVTEFLEIISHTVLFNYGGYPAETFDTASYGSILFHVSTILERFVFYSFIDQFILALKISVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFT2</accession>
    <name>A0A183HFT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein S-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005982">
        <property type="protein sequence ID" value="VDO46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFT2"/>
    <dbReference type="STRING" id="387005.A0A183HFT2"/>
    <dbReference type="WBParaSite" id="OFLC_0000634301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000634301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000634301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000634301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27647" checksum="B50777E4622FD83C" modified="2016-09-07" version="1">MLGSRYYRIIILQCFTLCRKFLDIIKLSLTKYFTVYLSPDKAADVIDYFTGIVFYNCTLHSLLEITDYFFTSLSIGAMDEVDSQHDVKYVDREGGDYVLLIMFTSTIDIETRVMTLRKICKSVSQALPATVAWSLIIVCTGCFFYLLAPAIILQFSAWGYILCAIDAILFLFVMSNLFMATTMDPGIHPFASAAEETQLDDFRSPLYKNVEINGITVRMKWCVTCKFYRPPRASHCSVCNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGQ9</accession>
    <name>A0A183HGQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6672</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006486">
        <property type="protein sequence ID" value="VDO47427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGQ9"/>
    <dbReference type="STRING" id="387005.A0A183HGQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000667001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000667001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000667001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18631">
        <property type="entry name" value="CD_HP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000007">
        <property type="entry name" value="Chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO47427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000667001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9944" checksum="BCD633B12160CE7A" modified="2016-09-07" version="1">MILFQDQEYVVEKIIDKRIRNGVTEYYLSWKGFPSSENTWEPEENLDCPDLIQAFEVQEKRTKEQKRAKSLERLGRGFFDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH36</accession>
    <name>A0A183HH36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6795</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006673">
        <property type="protein sequence ID" value="VDO47937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH36"/>
    <dbReference type="WBParaSite" id="OFLC_0000679701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000679701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000679701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000679701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7628" checksum="CF8EBA2E6682137D" modified="2016-09-07" version="1">MKKERNQQLLLKLTSNIVHLRGSNSLLISHSSLQLFTIRRLFYSQDNLPIDPSHNFLCHFIHVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHI4</accession>
    <name>A0A183HHI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006936">
        <property type="protein sequence ID" value="VDO48613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHI4"/>
    <dbReference type="WBParaSite" id="OFLC_0000694501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000694501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000694501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000694501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9553" checksum="7B24DA55F2648A1C" modified="2016-09-07" version="1">MECFDLNYILSVLMTISCRWTLLSKLDMVDDIHPRCPRMNREERGKRRGKFCFDQMKKIEKEWKERKVGKKRWKGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHM1</accession>
    <name>A0A183HHM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006986">
        <property type="protein sequence ID" value="VDO48717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHM1"/>
    <dbReference type="STRING" id="387005.A0A183HHM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000698201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000698201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000698201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000698201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29559" checksum="F76AB4A638193061" modified="2016-09-07" version="1">MLSIQDAPGNRMSSISRESGGSHSEHSTVDSRSCSASRGITREAMWGNFSPEMRKEMRALELVAVEREYNELLQTTLKEKRLRVERLSDLLSENDNTSSNQQLQTVPPLLPPGFPLSPLVLQTKTSSKISPVCTVSTFQSLEQEPFSHVETSSNIRDDELAQWLRSFGCDNNTIGRIQAEEYTKQDLLDFVTREDLMRLNLRGGIVCRIWRKILQNRERQQFSGFSSTTDFHSRHDSSEDFHSMPNDQEIFSVTELNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIU2</accession>
    <name>A0A183HIU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS7404</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007714">
        <property type="protein sequence ID" value="VDO50836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIU2"/>
    <dbReference type="STRING" id="387005.A0A183HIU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000740301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000740301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000740301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552552" evidence="8">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO50836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000740301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34514" checksum="3FCAF65771898CAD" modified="2016-09-07" version="1">MIYLVIFVISGTSQADCAVLVVACGTGEFEAGISKNGQTREHALLAQTLGVKQMIVACNKMDSTDPPFSEARFGEVTTEVSNYIKKIGYNPKSIPFVPISGFNGDNMLEPSTNMPWFKGWSVERKEGTMTGKTLLEALDSVVPPQRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILKPGMIVTFAPQNLTTEVKSVEMHHEALQEALPGDNVGFNVKNISIKDIRRGSVASDSKNDPAKETKMFTAQAIRFSSAKGHLMICGIWVIIMNHPGQISAGYTPVLDCHTAHIACKFAELKEKVDRRSGKKVEDNPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIY8</accession>
    <name>A0A183HIY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7449</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007796">
        <property type="protein sequence ID" value="VDO51072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIY8"/>
    <dbReference type="STRING" id="387005.A0A183HIY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000744901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000744901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000744901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="2">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000744901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24641" checksum="E1D27416F5D5FADC" modified="2016-09-07" version="1">MIIQNRDGLGIVYYNTALSSAKATHGGTVVSREADIVTAHELGHNWGATHDDLSQECSPPYSSGGSYIMNTFSVSGYDENNNRFSPCSRRLIGKVLSKKANICFEPEMSAFCGNGKVENDTNGFAEECDVGGLLSGTTDELRSGFIWFEDFGNIKWQMARTYSVASKMNLKHAVHQIVVSNRMQSVHQKTVHAVQVIVNFFHQLIFVFMKIDFNANFPLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJE2</accession>
    <name>A0A183HJE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008052">
        <property type="protein sequence ID" value="VDO51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJE2"/>
    <dbReference type="STRING" id="387005.A0A183HJE2"/>
    <dbReference type="WBParaSite" id="OFLC_0000760301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000760301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000760301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000760301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25190" checksum="474B16DB42960672" modified="2016-09-07" version="1">MVFNEFLIVFYPASVKMDQVTIHDYFYLIQMGCTPLSLPKVRRLPFDPLKHQTIHLERLMRSKGLVDPRLDEEYPLSYSENFPCNSNIGETVLLGDHNYSRFPTSPPPSPTTDIAESEMDYRIHYSYCMLYLLKKVAELLEHMRKTSNNPSILLSINQLSVIETAFEFIIPTAIRPYVDDGVILHLGKSNLVEHWRPIVGDIKFRKKQVIFVNDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJI1</accession>
    <name>A0A183HJI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation_ATPase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008118">
        <property type="protein sequence ID" value="VDO52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJI1"/>
    <dbReference type="STRING" id="387005.A0A183HJI1"/>
    <dbReference type="WBParaSite" id="OFLC_0000764201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000764201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000764201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000764201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4150" checksum="76F82E7F1B0B5513" modified="2016-09-07" version="1">MNTADAQDILGLSNNSAKDESLIPAGGLTDVDRKVLFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJJ2</accession>
    <name>A0A183HJJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF577 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008143">
        <property type="protein sequence ID" value="VDO52075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJJ2"/>
    <dbReference type="STRING" id="387005.A0A183HJJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000765301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000765301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000765301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000765301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="24026" checksum="8666D6E5782B5738" modified="2016-09-07" version="1">MHDDNSYRLREFLGKVRSSCMDYDGYWIEKLVKVLPKDNETNDALIESLKFGADKLSNQSNFYFIHLSLIKEIISNGDKNLWNCDFIKNFVRQFLNNTTFDGSAVVMNTLFMLYRELEEKNFFYEDEEVVQKALQLLNDNMDSVLKVTICNYLNKTFGRKYNTCWASAIIGLLKTSNSGSQHKRIGSSAWRERLFNGFWTRHFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJP2</accession>
    <name>A0A183HJP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008212">
        <property type="protein sequence ID" value="VDO52233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJP2"/>
    <dbReference type="STRING" id="387005.A0A183HJP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000770301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000770301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000770301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000770301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13943" checksum="10E8D6FE603DFE11" modified="2016-09-07" version="1">MYSDRIAQRPSEGSFVFSKLTAADEGVYQCEATNDNGTAISEKITLKQTWIRYFPKAEPEIIRVDLGDPYQRNCTPPESNPPARVYWIFKVLFFISFLFSCSLKGYSGSNRTIARFLRKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJR6</accession>
    <name>A0A183HJR6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7730</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
            <location evidence="1 5">Cytoskeleton</location>
            <location evidence="1 5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008254">
        <property type="protein sequence ID" value="VDO52329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJR6"/>
    <dbReference type="STRING" id="387005.A0A183HJR6"/>
    <dbReference type="WBParaSite" id="OFLC_0000772701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000772701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000772701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO52329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000772701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27225" checksum="8A429F80B2D9296E" modified="2016-09-07" version="1">MTEVIKVKLQLRFLFVLTFIRKSRHVRLLTPQPFALTGRAAQLSVVCEEELTRHMLMALQGIEGTYIICRGDKHAELQLSSMLAVDDTLRVQLLRLLPIANAYLQLRHESQKPTSDRLARAFSTGLSEVLASYMGLISMLYTKYMSNPRLFTCLDILVALSNWEILLPLFLKLVCVFERLKGMQIFNMLCSIYWSTANQFVQQFLYALLRPMLYIFHDCLHNWLVYGRLVDPGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJZ5</accession>
    <name>A0A183HJZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008391">
        <property type="protein sequence ID" value="VDO52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJZ5"/>
    <dbReference type="STRING" id="387005.A0A183HJZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000780601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000780601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000780601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000780601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26510" checksum="1452FF0600BF9106" modified="2016-09-07" version="1">MPSRRRLNIKERVTEIENHSIRSVPLLSAPKILDKTSHLVGNLINEEGETPFAVPSSQNINKSLNGHSRKKVIDHPHIIDFPKGGMDVKINTQNVAIVNDDRLKEQYQEDNVRIPEQSNHQLSRMKNGESPLLEVEKEHFLNDSFQEIEKQTNRVHIESEELLEELLEEVEPVVELEKRILKTIRPDATIIESQVSSIFFLFVLFTEISCILWKSLSILFKYRIIISEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLC8</accession>
    <name>A0A183HLC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8293</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009251">
        <property type="protein sequence ID" value="VDO54985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLC8"/>
    <dbReference type="STRING" id="387005.A0A183HLC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000828901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000828901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000828901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000828901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18743" checksum="F35B2C2A305941E4" modified="2016-09-07" version="1">MATRSRRSAAGSDSLNPAMIQLYDTGRLRRELKQRGLDTTGTRNVLADRLQEAVLSERNSRQAYSPPPQPEKLAKRGTKRSLKGDEENESELQTESIISPNAKRSQHSEEFDEINLIEESFSIELSRFVFNTALKIKCFRKNNNLKMNNLLSNSEFFLFSNLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLN6</accession>
    <name>A0A183HLN6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8396</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009452">
        <property type="protein sequence ID" value="VDO55470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLN6"/>
    <dbReference type="STRING" id="387005.A0A183HLN6"/>
    <dbReference type="WBParaSite" id="OFLC_0000839701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000839701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000839701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO55470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000839701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="26836" checksum="85A135C7EF63DF98" modified="2016-09-07" version="1">MELRYIGGIYAGNVKPTPFLCLCLKMLQIQPEKDIAVEFIRQEEYKYIRALGAMYIRLTFTSIEVYKYLEPLYNDYRKLRMMNNEGRFEIVHMDEFIDNLLREERYCDIHLPRIQKRITLEEVGELQVYVSALDEDLDKLSSSDSEEDDDRVHKRKERSKGMPRRRSYSRERERDVDRGRDRDRERERDRERERDNDRDKDRNRDRDRRHRSPDYRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMC9</accession>
    <name>A0A183HMC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8644</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009948">
        <property type="protein sequence ID" value="VDO56688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMC9"/>
    <dbReference type="STRING" id="387005.A0A183HMC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000864001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000864001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000864001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69979">
        <property type="entry name" value="Eea1 homodimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO56688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000864001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21483" checksum="144FB80CD4B6F32B" modified="2016-09-07" version="1">DKEESLSKLHVQLETEKNRLKEASKYNEEKNENLKQMKEDLNELRIVQRDLEKKKAEWLQEKRALQERCLTAESDLEFERERAIVNKRNFDDVQTAIRELGQVNQNLQMDFAKQISRKWLEDSEAINCRACDKPFTLTNRKHHCRQCGQIFCASCSSFTAKIASSRNPVRVCNACHEEIMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HND9</accession>
    <name>A0A183HND9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gag_p10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010630">
        <property type="protein sequence ID" value="VDO58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HND9"/>
    <dbReference type="STRING" id="387005.A0A183HND9"/>
    <dbReference type="WBParaSite" id="OFLC_0000900001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000900001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000900001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000900001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16018" checksum="02C993DB6AE7C295" modified="2016-09-07" version="1">MANFIGFYNNPAQNKRVGIDFPNITEWPQGFVPVPIHTVGKNTDYVGIPDAHCPRQNWLMKLVQQTPEWKNLVKKYTGVLEELATICKQSLSLKEVPRCVDAFYCEKLHAFKIPVSDNQFDQLQQLSYEIQNYENGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNQ6</accession>
    <name>A0A183HNQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9121</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010867">
        <property type="protein sequence ID" value="VDO58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNQ6"/>
    <dbReference type="STRING" id="387005.A0A183HNQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000911701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000911701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000911701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000911701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21055" checksum="1544AF74BF5B9E12" modified="2016-09-07" version="1">MIVPEEHHVESQLSLIGTEVEIKRDGKVYSATIKYCRQSGGYKVQFSDGHFEWVSEDEIRLLHGGIPRKRNDHESYSEKAGTVSSGAVDEEALSKNISGRRCISQIPGIKVTPTNGCHKQEEPNFCCVVCDQKVYQKEPQYIVIRIPACDACVEQKMVLLDGNTKNCEAQTCTSFLKNGRRIATDDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPA5</accession>
    <name>A0A183HPA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9316</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011293">
        <property type="protein sequence ID" value="VDO59669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000931601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000931601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000931601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF6">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552584" evidence="6">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO59669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000931601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11508" checksum="501B8BE6E9909353" modified="2016-09-07" version="1">MFTGCFISLILSFAFVIDVDAMRKQGVAVRGQFLCGSAPANQTKVRIVDTDTGPDPDDVLDENTTDSDGKFELNGSTRELTDIDPVLYVWTDCNDGLTPCQRKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPB0</accession>
    <name>A0A183HPB0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS9322</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="UZAJ01011306">
        <property type="protein sequence ID" value="VDO59703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPB0"/>
    <dbReference type="STRING" id="387005.A0A183HPB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000932101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO59703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19223" checksum="141518BEEB929074" modified="2016-09-07" version="1">MDYDAQMSLEWMEQRRPLFMILITAYVLFVVRAPRIWGRKRSRELASIIFYWNAFNALTNIVLFLGLLPEFLSSFHEGFYSSLCLTAGLYKSPRSGRAIFTFHISKIWELLDTVLVILDGRKTNILHVAHHIVTSISMIYSYQHIGAMARWIAITNLAAHSALYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPE0</accession>
    <name>A0A183HPE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab11 family-interacting protein 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9352</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011381">
        <property type="protein sequence ID" value="VDO59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPE0"/>
    <dbReference type="STRING" id="387005.A0A183HPE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000935101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000935101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000935101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47728:SF1">
        <property type="entry name" value="RAB GTPASE ACTIVATING PROTEIN 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47728">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000935101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24274" checksum="BE089D112949863D" modified="2016-09-07" version="1">MERENLQLKETVMRLERENDDLAHELVTSKIELRKNLDTAEDSVESLQGQLERCTRTIKDLEDENSGLRTEYDQVKEMCRREVQRLETEATRSQDIIKNYKGICSDLSYRLEKQQDDFKILRTRVAGVISQCEQCSIALAEFTEQKNGSLSKKVSPTEDGCGFKMIELMDKLEESEQRVRQLELSLAQTKLELVEAQCKNQDLNHQVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPM5</accession>
    <name>A0A183HPM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SEC63 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9437</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011554">
        <property type="protein sequence ID" value="VDO60567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPM5"/>
    <dbReference type="STRING" id="387005.A0A183HPM5"/>
    <dbReference type="WBParaSite" id="OFLC_0000943601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000943601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000943601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF5">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="8">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO60567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000943601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12059" checksum="3A933D0C61FC609F" modified="2016-09-07" version="1">MERENDLNGMAPPVVAPLFPQKRKEEGWWLVIGDHSSNTLFSIKRLTVHQKAKMVLDFTASAVGKLHYKLYFICDSYLGADQEFDLKFRVEEAGRSRKRARDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ34</accession>
    <name>A0A183HQ34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9598</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011941">
        <property type="protein sequence ID" value="VDO61789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ34"/>
    <dbReference type="WBParaSite" id="OFLC_0000959501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000959501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000959501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Patched" evidence="2">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO61789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000959501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7194" checksum="2DCD634316BCAE7E" modified="2016-09-07" version="1">MFLVVAISLIISALILGVIHPAKLIVAFGVIACPILAITVTFGLFALAQLRTNTIMLIMPFLVMGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQX7</accession>
    <name>A0A183HQX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9893</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012630">
        <property type="protein sequence ID" value="VDO64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQX7"/>
    <dbReference type="STRING" id="387005.A0A183HQX7"/>
    <dbReference type="WBParaSite" id="OFLC_0000988801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000988801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000988801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26/CSB-like winged helix DNA-binding" evidence="10">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000988801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10719" checksum="69C8F9E3C5EA5DA1" modified="2016-09-07" version="1">MLFVEESNHYPSLFNAAETSDLKKADKYDKLAEDIRSFMVHRKGQALTNEILQSFKNRVSSEDSFAFRSILKRLCKLQKNSNLWILKDEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSC0</accession>
    <name>A0A183HSC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10382</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013776">
        <property type="protein sequence ID" value="VDO68047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSC0"/>
    <dbReference type="STRING" id="387005.A0A183HSC0"/>
    <dbReference type="WBParaSite" id="OFLC_0001038101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001038101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001038101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001038101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16929" checksum="3A8DF2CE05B50B40" modified="2016-09-07" version="1">MRLKFSGKDAIRKTSSSLLNESKNLDEFKPPEAKRHRSSLSSSIRTGLKTEQSKGTITTSVIAMDEASSQENSDGDTTDSLNCLQPSNFSTSNHRWGKNTVRFASSAAFLAGPSTAREKNDQQHISTSHKNGRSVVGDITQSVNAKKLIILGFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSG8</accession>
    <name>A0A183HSG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013888">
        <property type="protein sequence ID" value="VDO68395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSG8"/>
    <dbReference type="STRING" id="387005.A0A183HSG8"/>
    <dbReference type="WBParaSite" id="OFLC_0001042901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001042901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001042901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001042901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14669" checksum="BCDE0519E47E1866" modified="2016-09-07" version="1">DIWRGKPSAVQGSIFRSFSYIVSGIGKSCWERNLHGETSLSEIALFGLDRLGKVERVIACSVDLSYFFQRFSASIIILCVLAFARAIELTFELPDNANQCFFEDIKAGIDCVIEYQELRKRTWFFPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTJ0</accession>
    <name>A0A183HTJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rad21_Rec8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10808</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014840">
        <property type="protein sequence ID" value="VDO71469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTJ0"/>
    <dbReference type="STRING" id="387005.A0A183HTJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001080201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001080201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001080201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001080201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24541" checksum="49D773C93CC9FC85" modified="2016-09-07" version="1">HLGSSICGIQQENSYIRIFFSEFCIKNYEPFSFLDGALDGWPEINEGKHDVGSRSSFATAAKILEGISSFDADEEQKDLNVDVSGLNDEIFGFDESLEGTVSTEFPFDNQLDKKLSNAVLAKNTEMAEDVFARTESLKREVFGHYGYYLPMNSIVATLIQTDSVEVEADMMRSKQREEEMEITQVIDTSSQYDSLNRTDFETAMDTAEVLPNTQPFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUC3</accession>
    <name>A0A183HUC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UNC80_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11090</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015561">
        <property type="protein sequence ID" value="VDO73738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUC3"/>
    <dbReference type="STRING" id="387005.A0A183HUC3"/>
    <dbReference type="WBParaSite" id="OFLC_0001108501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001108501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001108501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001108501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18798" checksum="578280A2906A3669" modified="2016-09-07" version="1">MSDMFEKMENAFMFGDLHLFINVINGVTLLHCENVTILRRCMATYLSMAIHFSTLFTNQGFFLIMPTILRCYSQRQTNPLLCRTIEYVCKQFYIIHRKPFLLQMAGAVANILDTTDNNFEVNPLKVKAKYWFNLLHSMEDMTDMNDPIDILDLVNEAKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUJ1</accession>
    <name>A0A183HUJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11153</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015740">
        <property type="protein sequence ID" value="VDO74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001115301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001115301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001115301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001115301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="7044" checksum="1E92416F351EC10C" modified="2016-09-07" version="1">MVLKMMMMMMVIVTLYLNQFLHVVVRELDSLRQLNITSMMMMMMIFLNCLIVHHRHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUN5</accession>
    <name>A0A183HUN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11198</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015865">
        <property type="protein sequence ID" value="VDO74638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUN5"/>
    <dbReference type="STRING" id="387005.A0A183HUN5"/>
    <dbReference type="WBParaSite" id="OFLC_0001119701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001119701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001119701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001119701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7837" checksum="5CF4EC25F3F214EF" modified="2016-09-07" version="1">MLVLSGRYLSRCIVSLPKRWSSDSIVVHRDSKINNPQTPFKFTAENMKRIEVMLTKYPVEYKNPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUW5</accession>
    <name>A0A183HUW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016104">
        <property type="protein sequence ID" value="VDO75283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUW5"/>
    <dbReference type="STRING" id="387005.A0A183HUW5"/>
    <dbReference type="WBParaSite" id="OFLC_0001127701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001127701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001127701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001127701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7517" checksum="B6D7D8E1F341E60F" modified="2016-09-07" version="1">MYPRLHIELAPIYEHLHDQISRFQQPTVTPFDIIKRRRRFDDLLRVWYFSVPIFFEYGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVJ0</accession>
    <name>A0A183HVJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11504</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016669">
        <property type="protein sequence ID" value="VDO76935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVJ0"/>
    <dbReference type="STRING" id="387005.A0A183HVJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001150201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001150201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001150201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="1">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001150201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7793" checksum="93E1E9F8E2E7201A" modified="2016-09-07" version="1">MPMLGAAYLNTVAILSSLNEITLFKEEEKNSLATVKIELEPTGMALGPKHFAISLNNRAWLYEIEDKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVJ6</accession>
    <name>A0A183HVJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11508</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016680">
        <property type="protein sequence ID" value="VDO76960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001150801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001150801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001150801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001150801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13802" checksum="F4519F9BCA4C3804" modified="2016-09-07" version="1">MKSIYFNELSNRKLHSEDDDAKLPQQKLNDVLFTMFHCYLYVWKKNISLNSGRNTLLLGRKRKKKEREREGGRRRKGEKGEETVVCLYVEGTGAYVRFVEHFVKSGRDFADFSSFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW77</accession>
    <name>A0A183HW77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017373">
        <property type="protein sequence ID" value="VDO78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW77"/>
    <dbReference type="STRING" id="387005.A0A183HW77"/>
    <dbReference type="WBParaSite" id="OFLC_0001173901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001173901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001173901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001173901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32494" checksum="CC17C878CC72B0D4" modified="2016-09-07" version="1">MEEVNLDENEEGPIAHHTRDATDRMIENPTKDDEQEHIARRTRDATKPMTEKLTKDDEQEGPIARRTRGALKRLNPPNLINCIWKAILLIAIVFILPVEAKIGEDCNWIAGVPFKVPRAWNCDEILEQHPKLSRVAVHTRTHVRIPAIRCSNITRTVCTKAFLRLSLSVVSDQTTTTPTSSYFCKELNDQRKLNGSILKQVSHNKWSTNHEVQYSYGWFGVRCQSTTNIEFTNGELFLYDGKGLVSDLDRTEHCATQSGVCITNNSIVLWDAKEASSKCLYREIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWA3</accession>
    <name>A0A183HWA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017451">
        <property type="protein sequence ID" value="VDO79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWA3"/>
    <dbReference type="STRING" id="387005.A0A183HWA3"/>
    <dbReference type="WBParaSite" id="OFLC_0001176501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001176501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001176501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001176501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8102" checksum="D1BA33724FAA0848" modified="2016-09-07" version="1">MVNSRTTISDGKPRSCSRSSGNLCPTGFTCTVVRRGTTEISRCCGKNFGCPQNSAAQINPITGSYVSCSITSAKYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX22</accession>
    <name>A0A183HX22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glyco_transf_7C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS12032</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018156">
        <property type="protein sequence ID" value="VDO81314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX22"/>
    <dbReference type="STRING" id="387005.A0A183HX22"/>
    <dbReference type="WBParaSite" id="OFLC_0001203401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001203401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001203401"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF46">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001203401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11580" checksum="BFB0B43167E0670F" modified="2016-09-07" version="1">MNAAFRLAESLNVSCVIFHDVDMFPQDDRNFYGCPPTPRHLGAFVSSLGYQLWYKEIVGGVLAISMDDYRAVNGYSNMYWGWGGEDDDMGQCRRFFIIYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYA6</accession>
    <name>A0A183HYA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cu_amine_oxidN1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12468</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039849">
        <property type="protein sequence ID" value="VDP11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYA6"/>
    <dbReference type="WBParaSite" id="OFLC_0001246901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001246901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001246901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001246901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17102" checksum="6DDF0AEBA2A89E55" modified="2016-09-07" version="1">MVDMSEMLGLSVKYDAKERIQVNSTVVDSLSEVNEYPIASKTMLDHFIQAAVIETGQINFTIESSVGGIDSYGDQVELASDVMEIAQKQIIRFRNLPSTASILPSILRKQQASKACRKIVISENFVELPIGADFDPSKLKPCKGAYIEMGTIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ4</accession>
    <name>A0A183HYQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VP37A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12616</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039883">
        <property type="protein sequence ID" value="VDP11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ4"/>
    <dbReference type="STRING" id="387005.A0A183HYQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001261701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22742" checksum="5335401411DBDACB" modified="2016-09-07" version="1">MATTPDGSLIQKLSSPPTVDLQGGILLDVKEFDEVDETDGCKVHVTEYHILSADGQEEMTKTCRRKLKIECNQSTRKTEIANGREALIEEKTERLFGDIDGFRQPIILVDRSKALMDLSNSEVWDFQDSAVSAVLQKTQEKFLNMLNEQKDQLINMFPELFSEMRTTSSLVDTPQTEVETIVNSDGSTTTRMRSSRAYRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZB5</accession>
    <name>A0A183HZB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039947">
        <property type="protein sequence ID" value="VDP12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZB5"/>
    <dbReference type="STRING" id="387005.A0A183HZB5"/>
    <dbReference type="WBParaSite" id="OFLC_0001282801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001282801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001282801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001282801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17825" checksum="745564CA843B9605" modified="2016-09-07" version="1">MDSSARGTAIHCDNMLTTRTSPSSAAVMLTGEAFYENTKGVRIAAAPLALGNSSVEPPFHYVKIIMRAVLAAMQIIEMDEYRREVSETKKEVISNAELTLSSVGQNSTLSKYEVFYKKQNRKSKGIDSTQDMSEPKDTAKEGIFGAEDVAKCESPHLPWICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZZ8</accession>
    <name>A0A183HZZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040028">
        <property type="protein sequence ID" value="VDP12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZZ8"/>
    <dbReference type="STRING" id="387005.A0A183HZZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001306101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001306101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001306101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF3">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="64"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001306101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25102" checksum="1E9D1D53D5E7224B" modified="2016-09-07" version="1">MASVITSANIPNIIPSSDEKYAEGMRLANDALQDMLELVNMPDFESHEGWKRKSANKNDITTFDFPLRPCFAEHWENFADITKYNKNISSIKIIDDLAPNMDVVYYAMKDFATIKGREFMMCRTFRSFGDEIIEAARSFDFMGAEHDPQKIRGHIILAGGRFRVCPEDSAKTVVDYVMCVDFKEKNIPKIIMDATMSTLIMQDAEFTRKQIEKLKQEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I062</accession>
    <name>A0A183I062_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovate family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13124</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040054">
        <property type="protein sequence ID" value="VDP12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I062"/>
    <dbReference type="WBParaSite" id="OFLC_0001312501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001312501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001312501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001312501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19013" checksum="872BC7EB136BC4A1" modified="2016-09-07" version="1">MPRPRKNFGTPRAMTFVKSNHFDSPFRSPYASPIFPHNTTMSSPYSRHSSLYQHQKRPYCHMSTPTYSVNSLTSGQYSPNWRGPSKAYSPYIYKNPQNMVDVSYLIQEYSGFSSTIPPDNRRDSRMNSGANEQFNVNEYVIPSMTANPWAKLEEFFVNCRLDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I123</accession>
    <name>A0A183I123_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">OFLC_LOCUS13435</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040197">
        <property type="protein sequence ID" value="VDP13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I123"/>
    <dbReference type="STRING" id="387005.A0A183I123"/>
    <dbReference type="WBParaSite" id="OFLC_0001343601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001343601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001343601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF18">
        <property type="entry name" value="INNEXIN UNC-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001343601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="50427" checksum="CD0C359CAB8D6B50" modified="2016-09-07" version="1">MFGTDLFEVKKLLDGTHQLRIDGHHVGSAGPGAGHGHKKEFGPAMILYYLASAFRTLYPRLDDDFVDKLNYYYTTTILASFALLVSAKQYVGFPIQCWVPATFTDAMEQYTENYCWVQNTYWVPMQEDIPREIYSRRNRQIGYYQWVPFILAIEALLFYVPCILWRGMLYWHSGINLQGLVQMACDARLMDTDVKSRTVYTMARHMEDEVQLAHLERHGHARACFPFFQAKGQCGRHCGCYVTMLYIGIKVKFLLCADDLTYGFSLLRDLMHEVEWEQTGMFPRVTLCDFEVRVLGNIHRHTVQCVLMINMFNEKIFLFLWFWFLTVGLITVFNSCYWILVMFIPSQGMSFIRKYLRALSDHPTKPAADDVSLRKFTNQFLRKDGVFMLRMISTHAGELMSSELVLALWQDFNNIDRSSAQFWDAEHGAGTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1D3</accession>
    <name>A0A183I1D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040258">
        <property type="protein sequence ID" value="VDP14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1D3"/>
    <dbReference type="WBParaSite" id="OFLC_0001354601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001354601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001354601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001354601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38511" checksum="3DDF4044EEBC896B" modified="2016-09-07" version="1">MDKISSIRVKNYREFSKMIAHTWKLFVLLIISIFFNAINGAPIDTISTEQTVGFIETNEYLSVMMRSYPVLKRLMQYFATLNSSDLLSAHGTCKSFYGLASKELNRRIRPLIIRNGKVSGRVDQQIYSTYEQKLADTEDFLELRNWQPQIALLFDDCDNRFSKKYMPCACPCYRIIPHNDRFAISFSYPPLGMLGNNYPQSAVIIPEMYNASVDVIYHDIDGWHFPEDVKSYTEQFEIKLIIAFRESVVTPSDIETDIDFIIPPRMENISVPICYVLHIDEIQFPWSDRLFIMFSGNNIKASTFLIGTTDEEKLRKKFLKWKVRLIPYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1M5</accession>
    <name>A0A183I1M5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cardiolipin synthase (CMP-forming)</fullName>
            <ecNumber evidence="10">2.7.8.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS13637</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="2.7.8.41"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.41" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01040308">
        <property type="protein sequence ID" value="VDP14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1M5"/>
    <dbReference type="STRING" id="387005.A0A183I1M5"/>
    <dbReference type="WBParaSite" id="OFLC_0001363801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001363801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001363801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001363801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25155" checksum="DE551635F7F52E59" modified="2016-09-07" version="1">MLCRKALSLAIYPNAVFLPSITFASSSRFLNSNRSIRICASQHTAKIKVRLDEKQNELRSKIATIPNALSFCRVGLTPVIGYLIIKESYIIALALFIVSGTTDWLDGYIARNVRNQSSLVGSIIDPVADKLLVTTLFVTLTYVKLIPLALTILVILRDVSLIVGGAMIRYKTIEKPITLVRYFNPSISPLQVTPTFVSKVNTALQMCTIAGSLAASISGFTDHPFLTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1S0</accession>
    <name>A0A183I1S0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS13682</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040332">
        <property type="protein sequence ID" value="VDP14389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1S0"/>
    <dbReference type="STRING" id="387005.A0A183I1S0"/>
    <dbReference type="WBParaSite" id="OFLC_0001368301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001368301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001368301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="13">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP14389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001368301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16867" checksum="F4848DB0880764A6" modified="2016-09-07" version="1">MVKQEKERTIDRSFKKENSFDATEGKDKNSYHATYEEILELIKKFANLYDKDGMEILKILREFPEFRDSTELQYKIVMSVIVLSYRLVQENVERRRRMIFEILGDQPSENEESENLDNALYRYMNQKAMDEHEINDINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1V9</accession>
    <name>A0A183I1V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13721</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040356">
        <property type="protein sequence ID" value="VDP14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1V9"/>
    <dbReference type="STRING" id="387005.A0A183I1V9"/>
    <dbReference type="WBParaSite" id="OFLC_0001372201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001372201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001372201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001372201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10871" checksum="6DCB5292B686C0F5" modified="2016-09-07" version="1">MALANLWVPQPGKYHEFADATRTYIPGAEYMSFLQNLPRRTFSTGSLFRGDNGDGISSENQTSSSSSVSSQRRNAVDLVDQDIIFERKQKKNTGMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I339</accession>
    <name>A0A183I339_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GAE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14150</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040626">
        <property type="protein sequence ID" value="VDP15683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I339"/>
    <dbReference type="STRING" id="387005.A0A183I339"/>
    <dbReference type="WBParaSite" id="OFLC_0001415901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001415901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001415901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="7">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP15683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001415901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17336" checksum="66C05B4E10014774" modified="2016-09-07" version="1">MKGLINNSSVNKISSKPATATLSDLDPFDLFSMDATEKASQPSTLAINTNGIEGILYVDNVFNENSVAALRLLVTNNNPLPIEAFNFQAAVTKAFQIELLPPSSSDLPANRQGTITQMINIRRISFSHPLKMRIKAFYNIDGRQQLIECLVPKIEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Y7</accession>
    <name>A0A183I3Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-alpha-acetyltransferase 16, NatA auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14449</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040865">
        <property type="protein sequence ID" value="VDP17091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Y7"/>
    <dbReference type="STRING" id="387005.A0A183I3Y7"/>
    <dbReference type="WBParaSite" id="OFLC_0001445701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001445701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001445701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001445701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38850" checksum="498E4E2AD9ABC412" modified="2016-09-07" version="1">MGKHEEAQECVKRGLKADLRSHVCWHVFGLVQRSEKKYDEAMKAYKQALRLDRDNMQILRDLSLLQIQMRDLDGYRDSRYRLLMLRPQQRIAWIGYATAYHLLKDYDMALKIVSEFCNSNRVELPEYDFEQSELILYQNMILRESGQLELALNKLEENASQIVDRVAYMETRAENDIEGRYEVYKKAVSMNPHAATPKRVPLYFLHGTQFESLLFNYLITGLRKGVPSLFKYLIPLYVDTDKVKYKDFINFLLLLCLSSSSKLFLAPFRYNPLPESPTTVLWLYYLLAQHYDKLGSVQQALVYINRAIQHTPTLIELYMIKAKIHKVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4H5</accession>
    <name>A0A183I4H5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14637</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041026">
        <property type="protein sequence ID" value="VDP17983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4H5"/>
    <dbReference type="WBParaSite" id="OFLC_0001464801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001464801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001464801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001464801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7986" checksum="42BBAE175D3C5573" modified="2016-09-07" version="1">MDGWMDGWIGRCRPDKMKGTDVEGRRTRSRGGRIYLKLCVTVTKQKDILKTRVTPDQMTLDMIEITTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4K7</accession>
    <name>A0A183I4K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14669</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041063">
        <property type="protein sequence ID" value="VDP18144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4K7"/>
    <dbReference type="WBParaSite" id="OFLC_0001468001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001468001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001468001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001468001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="11095" checksum="29DCE47A8D07BFDE" modified="2016-09-07" version="1">MEKRLIEMTINHLNQPTIHWDRIRRHHLCRYRINCKQILLLWVLRRKFRLSFGVFEVYYQILSSKIKRSQSNCFLICCFLSLILNFKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6B4</accession>
    <name>A0A183I6B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041867">
        <property type="protein sequence ID" value="VDP21123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6B4"/>
    <dbReference type="WBParaSite" id="OFLC_0001528701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001528701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001528701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="53"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001528701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24128" checksum="69D9BFB7BAF6E745" modified="2016-09-07" version="1">MCSNYSDSQTDDNIKIADIIMAMEISMRFTRGKDILTGRIMSNDTFSQQTRLRQFELIVKKKSIFINAHYLAELSPYFKVLCFENVFREAQNGRAEIKGERYDDIIELLHFICPNDDYVINRNITESNFALLTHFSSLLQLRDLRHQLESYVVNKVRMENYKAKIENLLEMITEALNASFSQDLMNILYQKLARYDLGYVEAVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6D4</accession>
    <name>A0A183I6D4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20S proteasome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041906">
        <property type="protein sequence ID" value="VDP21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6D4"/>
    <dbReference type="STRING" id="387005.A0A183I6D4"/>
    <dbReference type="WBParaSite" id="OFLC_0001530701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001530701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001530701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001530701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19511" checksum="4AE2971A42C3EE2F" modified="2016-09-07" version="1">YFVQILTKFFAELQANTQIYGRRPFGVGLIIAGYDERGTHIVKTDPSAEVVETLASSIGARSQSARTYLERNLDHFPAASLEQLVEFALLALRDTLPAEDSLSKKNTTIAVVGKGMPFKVMEDDDVQPFLDRIAGVPRTGQQSGSEIEFIQILYYGYESDKLIFQQQATTEPMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7D3</accession>
    <name>A0A183I7D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15644</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042534">
        <property type="protein sequence ID" value="VDP23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7D3"/>
    <dbReference type="STRING" id="387005.A0A183I7D3"/>
    <dbReference type="WBParaSite" id="OFLC_0001565801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001565801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001565801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH1" evidence="5">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001565801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9664" checksum="05DB3E6D4E785E6E" modified="2016-09-07" version="1">MMSSLFHEPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKKKNGQGTIEDLEFALANPGSHSKCVTIPRSLDGRLQVVQFYIFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7Y8</accession>
    <name>A0A183I7Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043051">
        <property type="protein sequence ID" value="VDP24253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0001586301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001586301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001586301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001586301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9638" checksum="649DC2A0980C7F39" modified="2016-09-07" version="1">MEGSSSRRDGGIHCLLAAAFCHSLLLLVSGGSFGVCYLPVIIIICRYDRRRRCRHYQNDVVVNLNLLTDRLIGFRPVLRSSSMSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8D5</accession>
    <name>A0A183I8D5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043539">
        <property type="protein sequence ID" value="VDP25803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8D5"/>
    <dbReference type="WBParaSite" id="OFLC_0001601001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001601001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001601001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001601001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8834" checksum="DE60612ECCC01AAA" modified="2016-09-07" version="1">MEAEKMEYEMEQLAQSAVIDVEDGEVPQEDRYNHLITATYRYKEVAVSPVTLPTTVATTSGNFTDMLIFSKSEISINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VPN1</accession>
    <name>A0A3P7VPN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007398">
        <property type="protein sequence ID" value="VDO49886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VPN1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="258" mass="29943" checksum="AD89109FC41AE1F3" modified="2019-02-13" version="1">MKQRYEHLIKPPVQLKRSKKLYGIVELEIEVTELLENISTALCHLQKLDLLSATNYDLRIFQKDIATLTDAVINLKCKVQKTFKNITFQEDIQCLASSKEISREMNSREVIDKTGHSIREPKELDETQNEFRSFHHRLAAGSSIIASEKKHPLITEEIKKKVMPEEKTEKPRRIHADEFEDIIEDSGYNHSESRQSVNLSSYDFSDNSEISTFPFLWKGQNVKKRKGSEGLKPREIKNSENMKQIFNVKAFSVETMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VR85</accession>
    <name>A0A3P7VR85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002595">
        <property type="protein sequence ID" value="VDO37567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H8B3"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="143" mass="16740" checksum="C2526B29D5680DC3" modified="2026-01-28" version="1">MLRRRLFTTLVNRKPFLKKRYLSAETVLSEDEYEKLANETLNKLADYLDTFPDKFSCDGEYDVNSSMGVVTAKISEKGGTYVINKQTPNRQIWLSSPLSGPRRFDLVQRKWISIRDNVSLDALLNNEFRKIFQTEKIDFSEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XBD9</accession>
    <name>A0A3P7XBD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000252">
        <property type="protein sequence ID" value="VDO26712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZM8"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="289" mass="32621" checksum="F31B8DFB29AB5AB1" modified="2026-01-28" version="1">MDAGGGSAGSSQAEAIDKEQVFDWILDLSDSNKREQALLELSKKRETVPDLPLWLWYSFGSMASLLQEVISIYPAIMPPTLTAGQSNRVCNALALMQCVASHKETRSPFLQAHIPLFLYPFLHTTKTSRPFEYLRLTSLGVIGALVKTDEQEVIQFLLSTEIIPLCLRIMENGTELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLHLAKEPSQRLLKHVVRCYSRLSDNPRQALQALRQCLPDQLRDETFTRILADDKSTKHWLKQLLKNIGFSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AMK4</accession>
    <name>A0A3P8AMK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011745">
        <property type="protein sequence ID" value="VDO61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AMK4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="116" mass="13581" checksum="2E34C9DD03C1241F" modified="2019-02-13" version="1">MIFPKFNAIIVSAIIISKFKINICRYLDKLIEIEDYLQSKLSVPYEGRQITYSDFCENNCETSDVVSIFLNMYREVHIRKKGNVKLTYPSMDVFGNRIYLANNIFQVELNNRIGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B3R6</accession>
    <name>A0A3P8B3R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040867">
        <property type="protein sequence ID" value="VDP17101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="98" mass="11123" checksum="4782B02A31707A9D" modified="2026-01-28" version="1">MVGPHAAVDRRMPMRFANIRGLVWRRDSSGTKAFLRSSAVSHFPSSIIPYPTPLCCHKERPVEQTAKIVSICHFVGVSFCTLAYSLKRLRMILEYLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CJ99</accession>
    <name>A0A3P8CJ99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041160">
        <property type="protein sequence ID" value="VDP18595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="100" mass="11770" checksum="2C27D31FA3BBDB05" modified="2026-01-28" version="1">MTDCKLAATLLLVQQPHHYNVTGSKRITQIERVINGSIYLITNPSANSDKRERERERALPDRLRDFEPSPSFFGVGERDFEPVCERDDRLRELRERELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXT5</accession>
    <name>A0A183GXT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS45</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000011">
        <property type="protein sequence ID" value="VDO24326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXT5"/>
    <dbReference type="STRING" id="387005.A0A183GXT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000004401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000004401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000004401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF15">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="191"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000004401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34967" checksum="24DC7349761CB764" modified="2016-09-07" version="1">MDYVIPATKTTEELFPVKYKQSDEDDQHLICIDQTRIVLKINDGDSDFIHASRVPLGNNPNEIIITQLPLSNTVKHFWEMVWQENVQIILLFLTLNEWKQHAENIRLIPGKGKCLHIEDFMILTHKNEFNITPDWLIREYYLSRNDKTRRIFWYHYSAWEPNRSPGDCEHLWPLHSSLRKMRRPYVCMSLAGAGRAGCYAALEWAHLMLHDKEASIINIVDCVHKVRTYRMHAVQTIAQFQFLYMGIQRHIFLIEKIRKEILSERTIFEAAKKCSSIEYKHFRSDDYPADDEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYF8</accession>
    <name>A0A183GYF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PDZ domain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS268</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000076">
        <property type="protein sequence ID" value="VDO25194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYF8"/>
    <dbReference type="STRING" id="387005.A0A183GYF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000026701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000026701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000026701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21674">
        <property type="entry name" value="SMP_PDZD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039275">
        <property type="entry name" value="PDZD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058801">
        <property type="entry name" value="PDZD8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21519">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21519:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26547">
        <property type="entry name" value="PDZD8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="59"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="339"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="919"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO25194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000026701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="129361" checksum="099FB682E0FD0A77" modified="2016-09-07" version="1">MLVFLWGVVVGAVLMLLVIYVLLFNPFGEISSHTAFIEQFQPLRLPEKLKQFLKEGDDEGRTFEWESCYNLSLILHFLFQEHKDSRRLRRWIHKKLQLELSDLTTRNTAGRLIQDIRVRDLSIGCKSPVIKSVCVEDYDLSQDESFKTLKLLVDVDYSGGFQSSVNVSMLFGRFAQLSIKLSRLSGQIRLKLTREPFTHWVFAFVGMPSLEFQVDSQWQGKQVKHLIPIITQKFRRMIQRKHVWPNYKIRYRPLFPNPLYQPSPPIRVGLADVQASSTICKGAFEYIKTTGLLEVTVLRCTRLNTALVNNGNSEVFCVVSVDHRPLMQDASRSSTRCITILLNFSRHGISESIGLTFSKVNSLLKFPIYIYFSPRYEVFQLISNTGVRSVQVSTVESFSSAERCGFKAGDVVLAVNNVPVTSERQLSKLLSGTSSELSVLVDRMIYEESNASFSTLNNDVLGDDSASLGDFDSEISVPENFENVRNKSGQMEKLERGSQRHSQSATGINSNVASNDLTTNILKDTRMHPCTNDKLVDISDLSKHSEPIKKAQTKTERDFILKKHVHIRRVRSEAEITKSDCLDSQKLKPLFTTSLENLPYSAHKQYQEIKRMQTNMTENCIMVSAVNKENSGSICSLNTDISADNYAKDFLQSPSRRQRFQARAAEMAAAGKARMSDFWYRHKDNGSGAEIALDALSQHDVDLMLLHTSLPTSGLEKRKRSPLIKTKRPVVLQNDGRDDTHDLSKVLPKTVTTKSLAMNEDVLWDQSLYFELSADTCRYLNVIVQARPLTVKATDVTISHDGQVEMDSSQMLGYTSIYIPQVLDDCQLTLSNCHQELFTLRPPFCIPARRKLTPKAAEESRRAGFDERLCYGDILLSFRYFPSGLPTDGNRSSAENGEGVKNITEISGMNSFEASSKARHNFETILLRGAAICAVCRGKIWLKMASHCTSCLLVCHNKCLPKVETACSQLPPIDDSVHEERLLPRRRRIAVRVSEKLSSTWKSVGRKRAYFHALTENKKGTIEQKIPIIQVGTDEVMPVERAIPDVFSMLELSENLSQMMYQPGNAYNEQMINAAKMEKIRSIIHQTTVERLNVMKNMKDIQSSGSLSFAVLEDRLQALAVLMLHYCAALQVFFLSINFAYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYT7</accession>
    <name>A0A183GYT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S8_pro-domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS397</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000126">
        <property type="protein sequence ID" value="VDO25646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYT7"/>
    <dbReference type="STRING" id="387005.A0A183GYT7"/>
    <dbReference type="WBParaSite" id="OFLC_0000039601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000039601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000039601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8 pro-domain" evidence="3">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO25646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000039601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27195" checksum="5C398D8282E9950B" modified="2016-09-07" version="1">MVLARKSLLSTYKHSFWDNRKSFCEIRPIEISSETNVVEDELACCSKANVFKPLAKNEKSSVLKRNWIRNRTSSSKLLNKHHRSLSRQQFRFSVTSFRICPLSAIVLSFILLSILEFSLVAADKPNFTDMGTELRPDSGSDNYNSNRSSSSYAAETSQSLRTTLRKVYTNQFAVRIKGGDILEADKLAAKHGFINLGPVLPNDEYFLFESRQTRKRSTRHRRNAQTNSIAREPKVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZQ5</accession>
    <name>A0A183GZQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS715</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000266">
        <property type="protein sequence ID" value="VDO26815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000071401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000071401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000071401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000071401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11171" checksum="6FF13EF51ABF9891" modified="2016-09-07" version="1">MTQIPAKKSSASQAIPSVKKKNSSRRSSRSRSRGRHSRRSTPPRTLASQTIKTDSVEKLLPTAVDHSVRNIVKEDSTSFENHSLVLISPYMNAIAVPFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H099</accession>
    <name>A0A183H099_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carn_acyltransf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS909</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000369">
        <property type="protein sequence ID" value="VDO27533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H099"/>
    <dbReference type="STRING" id="387005.A0A183H099"/>
    <dbReference type="WBParaSite" id="OFLC_0000090801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000090801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000090801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000090801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30893" checksum="9EC60C1D02B8C749" modified="2016-09-07" version="1">MYLKVRLPLPVNSNPAYIFPQQNFNSLDEQLSYTAWLIRGFCDYKDLIDRKLISREISTGRQKVNMCMEQYDRIFRCYREPSSPIDILHYKSTANGNERTNYKEHIITFVVFTRLDGVLLSQAEIAKQLEKVVKMSGIGDNKINTTIGGASVGDRDDAAKFWNFMKEDKQNQESFNWILSASFGVCIDLNSETKWSMNYESNLVHRGLHLLHGFGSKAMGLNRWYDMSIQVKIVLERSPNSRCIPESLIFLNLFTLVVRIILAKITAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0G7</accession>
    <name>A0A183H0G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS977</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000404">
        <property type="protein sequence ID" value="VDO27769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0G7"/>
    <dbReference type="STRING" id="387005.A0A183H0G7"/>
    <dbReference type="WBParaSite" id="OFLC_0000097601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000097601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000097601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO27769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000097601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="48686" checksum="2868D333699D7638" modified="2016-09-07" version="1">MNLPNLKGLFFWLLLFSSTFLGSIFLLFPLTPLMYFAPSTWRKIADCFIGYWLILPSSLCDFMGVKFHITGDMICFSEPALIIMNHRTRLDWMFFWNALYKMDPWLLTTEKISLKKPLKYIPGAGWAMQCAAYLFLERNYKNDMHTISDMITYYKDLGRHYQILFFPEGTDRGERAAKHSDEFAIQHGLPIYNFVLHPRTTGFSYIIQLMRQRNYLKNVYDITVGYPDKIVSSELELLQKGCFPHSVHFDVTKYNENDLPNDNYGLIDWINKIWREKENRLEKFYKADSLHRKFLHSNEKIIWPVKQRICLFFFSRMIEMELLYIEKSAQDIWPVHTTRIGYYCAFLFWTIISLIWIYFIIYFFFVKIYVFFACIFYIYCQWQFAGVQNLALKLSKNNNNNNNISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H222</accession>
    <name>A0A183H222_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000736">
        <property type="protein sequence ID" value="VDO29884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H222"/>
    <dbReference type="STRING" id="387005.A0A183H222"/>
    <dbReference type="WBParaSite" id="OFLC_0000153101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000153101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000153101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000153101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50892" checksum="40E05408823AEDD2" modified="2016-09-07" version="1">MSLCTHHYSCSYFTLASCQSSCEFLSCERPSKNVEIMHNCFCLQSLLKNATERELLLLPTLSYQNDDPSSNIRLRILLENLHCELGKASNVTIEVRDPNFWLEITGGIDQSVLKKLPTKDHQRSSGMCNGSPTRVYISRLSPWRAIIIALLVNPQNILMTTSFVTPTLPLLVFHCDEPLIAHHLARNEPRRCETYVSDHRTKSPTSTLAHLNRQIRKTEKFTKTKTNKLELHWLSTSRISPVENRVHTSFDLHSYCEAIEDQLFSRALIGAVYRCLLQGVHIPYEDLVEVLEDRCEQSDIEVEGVDECVRFLCSHVANICKQTENSATDANDEERNNDFFKDEILYRLNDGDGKSCEEEHEDFQFAFDELLSQNFRKIPNFPSYFYFVQNNGIHLANTNLTINLPETKNFTSGSSPCEDLEICYIEDEEDQEDEDGKRIREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2B1</accession>
    <name>A0A183H2B1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS1621</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000802">
        <property type="protein sequence ID" value="VDO30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2B1"/>
    <dbReference type="STRING" id="387005.A0A183H2B1"/>
    <dbReference type="WBParaSite" id="OFLC_0000162001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000162001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000162001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="590"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000162001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="975" mass="111733" checksum="C55F7368D5B35C12" modified="2016-09-07" version="1">MLCYNRIKALIDHTGLTDVKENDVSYYSNGDRAPVLPGDETTFEVRTEDVHSFGFMISWVAFNTTDMDHRKFLGYQVFYKKVDGPDSILSIDDDRSACSDSWQMHFEPEKGNGNEGLNRGAGIFAVESNTWYAYYVQTKLINHPGARNAISKIHFLKTLFSTPDPPKDVVGKSLIMKPDQIDLVWEPPERPNGDITHYIVKWQVLGDDPSTVSGNVCDDKIGLRHHKYINDRLTHTSSAQQSCSKAGCCECRLLREQQQLQQQSKSSNIFLENERINEADFEKSMQNLVFVQEHSKKSLAEKLRIRRNRRSILKDYNEPNEKLYGDEKFILITQNELNETISLYRSELDIGTHKINVTTRRLSIIGLRHYTQYQIWIHACQNVSAPGGAFCSQRPGWMVVRTAPIASNDLVDNRTIKVINSTSFKQDPRSRNITWQEPSNPNGMILAYRVTVVAENVAQTPISQCVKASNFREREGVVFNGLAEGEYLVQIETISMASLSFHAIKEIAVAHKLFKIVKPTFFTTTIISFIVVIVLLVLSVGSLAAYYISRKILGEKVREYVRQQISANPEYLSQMDVYKPDEWELKRSAIHLEEEIGRGTFGKVYRGYGNNCTSYLGDVFGECAIKTVSEAANSAERLHFLIEASVMKQFNTAFIVKLYGVVSDGQPVLVVMEMMKKGNLRDYLRSRRPNAEENIHGLPVPVEIDFLRWASQIADGMAYLESLKFCHRDLAARNCMVNEFDTVKIGDFGMARDIYYHEYYKPAGRRLMPVRWMAPESLMDGKFTMKSDVWSYGIVIYEMLTLAQQPYLGLANESVFDYIGVKKKILTRPTGCPDFWYELMEQCWKYDPRERPTFAQIVRILLRHARAGIHDFPDDEFREVLFLHMSFVVSNEINIDDDLDEEMFPVNDNTRLVRTISAGYVDQSETSFINTPDKQVLNHSNSSGNIYYLSNNNEENNQTKVSIDLFLITFFLYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2B7</accession>
    <name>A0A183H2B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCM2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1627</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000806">
        <property type="protein sequence ID" value="VDO30225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2B7"/>
    <dbReference type="STRING" id="387005.A0A183H2B7"/>
    <dbReference type="WBParaSite" id="OFLC_0000162601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000162601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000162601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026159">
        <property type="entry name" value="Malcavernin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642:SF6">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS 2 HARMONIN-HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000162601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40807" checksum="49973C6B5216B5CE" modified="2016-09-07" version="1">MTHNPLSATFTGSSSNCQCREYAGLVHDIRGDIDPSGRTDLLKILDLAKVFFSGNSKEYRNNRVSLLQITNQIESFDEKNKFTTNAILQIDLCSITVRSIFENELLLYVPIHLIASVGFVREAHEYILPVKVGYSSARNRDFFDLAVVYCETANVAETICNVLGQCFSQVYKEIASNFEASAAPKKTPTTSSVSLLNHRPLFLTESHQDLRISSGHPPCSTTASHSESAEVQIDDVVEDYMTVLTKCLTTNELSQYATLIVRFRNGSMSIIELAQKSSELYGPDRLHLLTVIQIYPSTLHCSVICLASTDVTHLLDYLCLKKIRIIGMRCLLRNRSKEEIESFDGFIEMLRLSNKGEVQKKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2D9</accession>
    <name>A0A183H2D9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CxC5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000821">
        <property type="protein sequence ID" value="VDO30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2D9"/>
    <dbReference type="WBParaSite" id="OFLC_0000164801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000164801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000164801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000164801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17100" checksum="256A6F16267746C0" modified="2016-09-07" version="1">MFETLVTVLEMIVFCRVKCIESRHTIAYVLVPLSSEATMRLGLKSNGSEIFIPCSNCFFKYDRSNNRLMQYYNRPSFGETPQLCGCFEYLSKGFMNTKTPTLISISRNIIQIEVNVYYGVMKTDQCRLDSIRSARTVDGLQLALQMRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3H8</accession>
    <name>A0A183H3H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1534 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2038</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001096">
        <property type="protein sequence ID" value="VDO31656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3H8"/>
    <dbReference type="WBParaSite" id="OFLC_0000203701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000203701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000203701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000203701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7920" checksum="0331CA8F654F1956" modified="2016-09-07" version="1">MGERGRVLCTAKQAVITRGQNSGRARTCRQNKQAERFLLQAGLLTPRARRDTCDARCTPACKHSSRTALYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3R6</accession>
    <name>A0A183H3R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2126</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM59 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001163">
        <property type="protein sequence ID" value="VDO31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3R6"/>
    <dbReference type="STRING" id="387005.A0A183H3R6"/>
    <dbReference type="WBParaSite" id="OFLC_0000212501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000212501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000212501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022065">
        <property type="entry name" value="Uncharacterised_TMEM59"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12280">
        <property type="entry name" value="BSMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552367" evidence="9">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000212501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17229" checksum="AC99AF16D21830DD" modified="2016-09-07" version="1">MYGFILLGTFLLLLAKTQSQEECVTECDKAQTTEKSKDACKEGCRLQIIFAFASNSDIISTRKDCYNGCAKSYNDDAEKQACSFGCDKQPDMKKSGIRISITNKSPTFQVARGAMEKMMHRISNSFPSPGYVHQDFIGIQIVAVQICSYLLLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3T6</accession>
    <name>A0A183H3T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS2146</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001175">
        <property type="protein sequence ID" value="VDO32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3T6"/>
    <dbReference type="STRING" id="387005.A0A183H3T6"/>
    <dbReference type="WBParaSite" id="OFLC_0000214501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000214501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000214501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="13">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="252"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000214501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69345" checksum="72EBEB1436F491BE" modified="2016-09-07" version="1">MAVDQLIDSYVPYTVKPIIAHAYAGPFAFLYVGWAYLWFNVYGVNEYWELGCIIMATIGILQILTVLFCNWFVNVHCLLTCSYESNVERATVVKVVPTPNNGWAEVVPLHRTKLINGKMKLWFEFQKVHYTFVLERKTFSALELDTNQPMSYFYESRGLETDEAILERKQDLGDNRMEMVIPQFMELFKERATAPFFVFQVFCVGLWCLEDMWYYSLFTLVMLMTFEATLVKQQLKNMSEIRNMGNKPYLINVYRNKRWNRIKTDELLPGDIVSISRSPDEKAVPCDLLLLRGPCIVDESMLTGESVPQMKEPIEDVEKSRYFDIETDSHLHVVFGGTKVVQHTSPAKNEAGMKAPDGGCICYVLRTGFNTSQGKLLRTIMFGVKRVTANNIETFAFILFLLVFAIAAASYLWIKGSEDESRSKYKLFLECSLILTSVIPPELPIELSLAVNNSLMALQKLGVFCTEPFRIPFAGKIDICCFDKTGTLTTDNLIVEGVASTNCLCSSDECHIHRLPSEVPLESIQVLVTCHSLIRFDEDLVGDPLEKACLNWAEWNLTKNDTVIPRKSKMQPLKIFRRYHFSSFFKRMTVIAGYVATGTNETKYIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4K0</accession>
    <name>A0A183H4K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein SPEC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2410</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001383">
        <property type="protein sequence ID" value="VDO32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4K0"/>
    <dbReference type="WBParaSite" id="OFLC_0000240901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000240901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000240901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071683">
        <property type="term" value="C:sensory dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019230">
        <property type="term" value="P:proprioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050954">
        <property type="term" value="P:sensory perception of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF7">
        <property type="entry name" value="PROTEIN SPEC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000240901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27238" checksum="FF787779855C6C7B" modified="2016-09-07" version="1">MYNVIFAVNESNKRGENDRSRGWKLVQKALPRIIRYGQNEGILHTGTSFVCYIFQLDSFYNMPSVVIQAQVAADISDHRLADKVQIPSNDITIMHEAIPFLPVPVALLCLFFNIIIPGSGTILSGISALCMGQPRINFKEGRKLITLFVNFLVGISQFFTITFLFVGWFWSIAWGGLIIIHSMQYRDALMQRRQEAVATAAIEALTKDSILHRRDVKKLIEAHRKMSIQKQRKDSTKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H662</accession>
    <name>A0A183H662_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS2973</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01001856">
        <property type="protein sequence ID" value="VDO34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H662"/>
    <dbReference type="STRING" id="387005.A0A183H662"/>
    <dbReference type="WBParaSite" id="OFLC_0000297201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000297201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000297201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF183">
        <property type="entry name" value="MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="151"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000297201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31354" checksum="8F90D7DBFAB43EC6" modified="2016-09-07" version="1">MSLNGKLIDVQTSQQQQLSISIPVKNEQEMPMHQIHEDTAKIENEDKNKRTPDNSTIGTRIVQILNSVHKKPVMHFLVQKYSTSYDRPATPDYTRVSHYRECQQTSCRSLRLANKEPPRGPFFISFKKKPVMIETNYYNERCHMSFFDQSFSNKRCIGKGSFGEVFKAFNKDDKRWYAVKISIEPFRSSSDRDIKLKEVQKHELLPKHPNLISYIRAWEEYGFLYIQTELCQCSLLDYKMKVGTIAEKDLWLFFGDIAQVCHFRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6B9</accession>
    <name>A0A183H6B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001901">
        <property type="protein sequence ID" value="VDO35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6B9"/>
    <dbReference type="STRING" id="387005.A0A183H6B9"/>
    <dbReference type="WBParaSite" id="OFLC_0000302901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000302901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000302901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000302901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15059" checksum="4AB6F0F2D8484E09" modified="2016-09-07" version="1">MLSASSGNCSTSVTVAKTSVTENAVTLGNCYVVAPDGIPTTSCGRFEADDDGGDNEGGKNGSGVCDANNGVVPMESIPSSSSSTPSSSGLGPTGAVPVENVTSTGKEELGPVSRDRCNTWPMRRPQLDINAQTSPLIHEQIPEEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Z9</accession>
    <name>A0A183H6Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3261</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002126">
        <property type="protein sequence ID" value="VDO35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Z9"/>
    <dbReference type="WBParaSite" id="OFLC_0000326001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000326001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000326001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056656">
        <property type="entry name" value="DUF7754"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24937">
        <property type="entry name" value="DUF7754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7754" evidence="1">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000326001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42127" checksum="218A1972A188585F" modified="2016-09-07" version="1">MGDSDANDFKELLYQIYPTKRPIWANLEGLTRAAVGFRADGIIDRITSYIVNYESMYMEQKITEAIKLELPNVIEELVYKAEQDGYWTNIIRNGLNPELEYGDAIYNSIILPAVAKAKSLPLGTPIREQFFKEIDFRSPPENVNDHDTVVLIVKGTKLYVNKGIMKVNNDAMFGRSNRGEMIAQVNCELAEECAKIKKTPLYVVEALLQHIYPQNRPIESILLRPLLVFCNSYQMTNAMNSIENHLIQEPPTSPERLIEYFELAEKYSLENLLHRNLHRIENSCRHFALPMINHEKFKKLKERTKSQILDRFCSGWAAGGMNPTKRLSRLLTKEGIEENTVAEQDKKLSTFMEIDSRAAFGSSEEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H736</accession>
    <name>A0A183H736_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Leptin receptor gene-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3298</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002166">
        <property type="protein sequence ID" value="VDO36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H736"/>
    <dbReference type="STRING" id="387005.A0A183H736"/>
    <dbReference type="WBParaSite" id="OFLC_0000329701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000329701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000329701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000329701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13673" checksum="508D076ABFDE3120" modified="2016-09-07" version="1">MKQFILLFVEENDIVLAVVLLALSGVVGLTLLVLGCALPMFGVWWPLFVIIFYVLVPVPLSIARRSHVDMTGTSACIEFALFITTGIVVSAFALPIVLAHAGVVSFTNLFKVLKLLSFIEAFKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Z5</accession>
    <name>A0A183H7Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3607</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002471">
        <property type="protein sequence ID" value="VDO37128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Z5"/>
    <dbReference type="STRING" id="387005.A0A183H7Z5"/>
    <dbReference type="WBParaSite" id="OFLC_0000360601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000360601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000360601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO37128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000360601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16674" checksum="63BC58BBDD695362" modified="2016-09-07" version="1">MGTLSTARLKWVCGDAEELPFDANSFDIYTIAFGIRNCTNIDKVLKEAYRVLRPGGKFACLEFSRINPLLRQFYDFYSFQIIPIMGQVIAGDFHSYRYLVESIRKFPDQDKFKRMIEEAGFKDTNYSNLSCGICAIHTGIKSAANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8C8</accession>
    <name>A0A183H8C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IF rod domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002608">
        <property type="protein sequence ID" value="VDO37628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8C8"/>
    <dbReference type="STRING" id="387005.A0A183H8C8"/>
    <dbReference type="WBParaSite" id="OFLC_0000373901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000373901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000373901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000373901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41074" checksum="E843780D7413EF63" modified="2016-09-07" version="1">RRTGFDLGIEGQDEKQIIEEQLKNLDKEIQLRGSELGDIQKKCTKAYSDEQREQLWNALRNLTEAKTGLERLFDATINERRSCLEKDLVIEELKRGMDEMKNFYERKLHAVRMELENAKTEVGSLRRTLAETELCYAQQERDMINIWNEMVEGHFDLPENVVKNLNLVKEAANNFTNLQQAFEQQRHELEKSRTRVYHGRMRRKTGPIDGIMPGRSLSESILEESGGGGDLRGSYQIRENRRPVERLGVVTDLGSIFPDEKEENTSVADSDFSYCPTPQRTTRKRQSSVAKVAGRRDTFVLSEAPLKKIDTKQEPEGEPVAGCSKESDFNPNATYTVEQCSELNHRSIITRDLFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8W3</accession>
    <name>A0A183H8W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3928</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002797">
        <property type="protein sequence ID" value="VDO38253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8W3"/>
    <dbReference type="STRING" id="387005.A0A183H8W3"/>
    <dbReference type="WBParaSite" id="OFLC_0000392401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000392401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000392401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000392401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22641" checksum="CF4C885EEE593A48" modified="2016-09-07" version="1">MSYRIKICHNFNNLQQQAGAVATALPLFSESNRAPTADCSGVEDLYIMDDFLPTPIEAVPNSTSSQIENQLPEAARQELLTFGDRFLADSNIEQISDSHSVVVKFSLTSHNVPPLQLIIPKTYPNGEVLVGRAALDLDSFFFDDLQNVIHERLARPGLRTVADFLETWESTVRGYYLGQQQQSLLPSSFDDILQNTNFGDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9S2</accession>
    <name>A0A183H9S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4234</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003133">
        <property type="protein sequence ID" value="VDO39356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9S2"/>
    <dbReference type="STRING" id="387005.A0A183H9S2"/>
    <dbReference type="WBParaSite" id="OFLC_0000423301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000423301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000423301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000423301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24229" checksum="493B6F3724E73B50" modified="2016-09-07" version="1">MVANGSKRKMHAGACLAVLMFSACLLVAPNLSPLSKKRNEEETEQITTPAIQPKRNPPLAGRSRSLLQFVSSVTDKFDVDFCDEEEEYEDASALNSVNHPMAFKNNSLTRKEKRVAFWNENATVRTQPHLAEMTSRALSNYDCVRIGSYSRKRKVLPQEKLYSVSPDYNKPWIRTINSAEYKHAKLSNGSTLRVYTNPGNYISVDSKRLKIQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9X1</accession>
    <name>A0A183H9X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4283</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003185">
        <property type="protein sequence ID" value="VDO39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9X1"/>
    <dbReference type="STRING" id="387005.A0A183H9X1"/>
    <dbReference type="WBParaSite" id="OFLC_0000428201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000428201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000428201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF7">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000428201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60188" checksum="221ACAAAC0130278" modified="2016-09-07" version="1">MDPSILRKHKNSEELIYKNGLPFDKDRESLKWDGNPKDGSGKARQQIHCKCILREGIAHRTVEKKMQHFLVWTAPGIGMFCGSFFTSWFLRSFGGRRFFAVMMILSAIATVLLAMTPQIKYGRYLTVCMRFIQGFAFSSVFPMIGLVTANWGTLKHQFLFLICCTCFIQLAPLISWPVSSFIFARDYRIPFFIHATVTCLLALIWLVFFREKPQYHFSVNGLELNKIVAGKIKGTAVLKCIFKSLKCASFCHTDPQKRSSLKPKAEHNRILAENPCRLLIMSFPVWAIWIAACGYFVVVSVAVQFLPLYCLLIVRETRTDSGILAAVPFLFMISFGNLLFVFPFQFIMMQFHGLWYRLAKFFTERISILAFNTISFIICSLIFIFLAIFPPGGTFHHSVVAAFTLILCILTFSVYGFYRSAVLVGRFFGQFIISYIRFFIGFAFFFTAATAVFFVEENNADEWRVMFLILAAFLLICAAVFGIFGSASPEEWSKDSWDPSAARPMITFDQIDYHADECGILEMRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAV7</accession>
    <name>A0A183HAV7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4619</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01003599">
        <property type="protein sequence ID" value="VDO40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAV7"/>
    <dbReference type="STRING" id="387005.A0A183HAV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000461801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000461801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000461801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000461801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17132" checksum="0ADBCBBE15AD6A99" modified="2016-09-07" version="1">MMQRRGQQPRAHLLLPVLPSISGNKMSASDPEFHLDLLDTPKQIKQKIARSFCEPGNLKGNIAFELAKHFIFSYFGPRLVIERSEENGGNLEINGCDELERIIVGGSLHPADLKTIVISKINQFCEPIRMCFATKTKAELISAAFPNKKGRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA3</accession>
    <name>A0A183HBA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Occludin_ELL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4765</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003791">
        <property type="protein sequence ID" value="VDO40977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA3"/>
    <dbReference type="STRING" id="387005.A0A183HBA3"/>
    <dbReference type="WBParaSite" id="OFLC_0000476401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCEL" evidence="5">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO40977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18493" checksum="D6793DC2001C855F" modified="2016-09-07" version="1">MSSANAGLSPNFASQSCRDWLKEFPEPRSLEEAENYYLKFLEDYPKYLTCYNVLSAVVNEFKELEKKMNEAPKNSKEHEKAEEAIEMRYMHYQHDPEYLETRQRHENLRSKLEILKKHVDFWEKNQRRQLTTDRTSLNNNGNSNNHHTLKHTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBF4</accession>
    <name>A0A183HBF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FA_desaturase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003854">
        <property type="protein sequence ID" value="VDO41144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBF4"/>
    <dbReference type="STRING" id="387005.A0A183HBF4"/>
    <dbReference type="WBParaSite" id="OFLC_0000481501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000481501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000481501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000481501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16939" checksum="3909E5EE62D7AA50" modified="2016-09-07" version="1">MIISCFGWKAFAYLLGGFLIGSGMHPLAGHYISDHYVFKPGQETYSYYGPINFVTFNVGYHIEHHDFPYVCGSNLPKIRTIAPEYYRDYMVHSSWIYIMYDFITNPKMSLRSRFIRKTAKPTDMHFFDLGPNSSCFIYKFFTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBF8</accession>
    <name>A0A183HBF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UNC93-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4820</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003858">
        <property type="protein sequence ID" value="VDO41162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBF8"/>
    <dbReference type="STRING" id="387005.A0A183HBF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000481901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000481901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000481901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000481901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55392" checksum="AD225015FB651990" modified="2016-09-07" version="1">MNKLKGRHSESSKMSVIMNEKPKVSESVSSILKPTLSYHQSTTASPEQPVFTVDEQLSVLSSSSIPVNREASSYRSSFRENEVETKCAYLFRGDSLYNKKKSEHGSMEDNIERVYVYDPFCPIHGSRRRMISRKTRIRDFDYHLTSIESVDDTEPSGVILLRKEIHFSISNFNQGFAAKLIRKRRRALLSGPEKYRCDKAKRKIRVNLWIVSLAFLFLFTAFHGLQNLQSSINGHLGTDSLSVFYISLSLSYLFVPSFILNRLGCKRTLIASSGIFMIYMLSNFLPKYYSLIPASILAGCAGSCLWAAKCVYILECGTKYAQLNIEAQNVVIIRFFGYFFMVLHMGQVIGNVISSFILTAATGYHQLEDQVQKCCGHFFPDNVSYLSEQAIENLRRPTQSVYLSLCGIYFCCTIVALMIVLLFLNSLRKDEIARFMPIFWRFFFLGRMKYQNIMEIIFGNIKQNKRKVSNIRKYQVNQLKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBM4</accession>
    <name>A0A183HBM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPX2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4886</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003936">
        <property type="protein sequence ID" value="VDO41343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBM4"/>
    <dbReference type="STRING" id="387005.A0A183HBM4"/>
    <dbReference type="WBParaSite" id="OFLC_0000488501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000488501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000488501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000488501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39957" checksum="80D339ABDA917B02" modified="2016-09-07" version="1">MLDVYQTKDFRHVKLKPTSFKTVDELHEREIRWQKETLGSLGEAFKNAPKADQQKLMRVERSKSPTEPLESAELIEKFTRPKNEQFYNQLTYIETTRPTFESMKLEDIALKPGHIEKYEPTKEKMERVELRAAPKVEKEAALAGASVAKPQWAVEKKLGNVESRFRRLPEQEKEVVIPARDQVKFKLAKPKPASELPSAHHVEIQKEKAKLASVKQGPEIPKEAEVPAKDQVKIKQKFQPKVMKPSEASVIESSPLKETPAVVKGKIAESTIPSKRAVLYQIFHERSQHAVEVNLAEHEDLISEEYMKYETYNYSRRMRERVLGFRILRHVVVSTIYLNFFRLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCG7</accession>
    <name>A0A183HCG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5179</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004309">
        <property type="protein sequence ID" value="VDO42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCG7"/>
    <dbReference type="WBParaSite" id="OFLC_0000517801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000517801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000517801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000517801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12969" checksum="6858553B557B839C" modified="2016-09-07" version="1">MKGVKNQHSKLWVVITTIVCLLDIIEPIDGQTPIMKPKKRRYKLIPFYDDDIKISDPSKPALIQDLLLLSRVLNNTADTVFGSKDIARDLLTFFADLDQIMMLAHFSLKRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCW4</accession>
    <name>A0A183HCW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ski_Sno domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5328</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004522">
        <property type="protein sequence ID" value="VDO42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCW4"/>
    <dbReference type="STRING" id="387005.A0A183HCW4"/>
    <dbReference type="WBParaSite" id="OFLC_0000532501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000532501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000532501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000532501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32336" checksum="495EF83203381390" modified="2016-09-07" version="1">MQERLKLFCKECALTNLTMAEMVSEAVEADTFLRIYEAIEDSSRKIQIPVRHLCPIRKVVWSSFDYMSGPELGFTWEAVIPTNESTSSCKSSLSSSSRDDSSLTSSMTRGAGSAADYEEIDDVYRQASELPYDIFKMNILMCNDEQSYLDEFMTESRSTIDGTTTVTTGDSHHMKHLTSLTSMSRNGDFESSTNSDKDSSVYKVEEVTGICSLNETEDLLTLDETSAKNNKDLQGMVSSGIDSGIVGTVSMHSELSTVASHVKEILKLKPDEEVIQKSCIVSYNRTVTCNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCY2</accession>
    <name>A0A183HCY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS5343</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004542">
        <property type="protein sequence ID" value="VDO42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCY2"/>
    <dbReference type="STRING" id="387005.A0A183HCY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000534301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000534301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000534301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000678">
        <property type="entry name" value="C. Elegans Homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF41">
        <property type="entry name" value="MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000534301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25775" checksum="CBC701D29C58358F" modified="2016-09-07" version="1">MFIHRCVQIFSIAVPRLGSGFGLNCGINPAHAAMQGLQLPLSSHVGSRRKRRVLFSQNQVYELERRFRTSKYLTAPEREALASSIGLSATQVKIWFQNHRYKCKRQEKERKMTDGSRGREESHSPGPSRTPTPLEGSNIDKKMNVSILVKDGKRCDNAHVASAPDSNPEHLLNLSALPDNIPDLKNQFYQQAMCQSSNMYQQGTFPFPPFGAQPYPTAQNPYYPYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD50</accession>
    <name>A0A183HD50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KLRAQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004630">
        <property type="protein sequence ID" value="VDO43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD50"/>
    <dbReference type="STRING" id="387005.A0A183HD50"/>
    <dbReference type="WBParaSite" id="OFLC_0000541101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000541101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000541101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040024">
        <property type="entry name" value="PPP1R21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019343">
        <property type="entry name" value="PPP1R21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448">
        <property type="entry name" value="SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10205">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000541101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40073" checksum="2DA137C7CD4F5933" modified="2016-09-07" version="1">MLINLHNSESALRKLESEKEGFEFRNSQLVKRVESLQNEIDDIKQASVKKRGLLFQKNSRAERSVELDNEVLQMELQKKVAENETLHKKISELENEYTEATSTLNKQYRNLEIENEKLKEELKKIRTNVVTDQSLDFNAEKQSEIQLAAENASMVEAAVTVNQNLVFHSEGHVAMRETLQILWLDALRIARMLAAGFANLLQLFEQRSTIYPNDSKMEKLPDRTLLYGRRLLSSCDMFEACSSNIENILVKNVDDDCRNLSDECSAIISEWQELFCENSANENRVSWCGTNLSKCNEEWTASFLTFLRSLVVLSRQIECSQSALELFTLIEKLSASLAGIICAVCCNVPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDL0</accession>
    <name>A0A183HDL0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5572</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01004854">
        <property type="protein sequence ID" value="VDO43587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDL0"/>
    <dbReference type="STRING" id="387005.A0A183HDL0"/>
    <dbReference type="WBParaSite" id="OFLC_0000557101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000557101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000557101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000557101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17145" checksum="7145AC71AD5047DB" modified="2016-09-07" version="1">MFQTTDLDNLSEMIRLSSFQTWICRWRALSCSGDHNHIPLLRSIQRKSIISFQHSFYAAPSKEDIDSGRWYPKHITDLDHICNQVIMYDPNNSWGLDANHPSFKDKEYRKRRESFWDVANNYKHGTPIPRVNYTTEETKTWYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDM9</accession>
    <name>A0A183HDM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc_ribbon_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004882">
        <property type="protein sequence ID" value="VDO43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDM9"/>
    <dbReference type="STRING" id="387005.A0A183HDM9"/>
    <dbReference type="WBParaSite" id="OFLC_0000559001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000559001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000559001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000559001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7889" checksum="10BD6EF0B6750142" modified="2016-09-07" version="1">MNGFTGTISTILSTANKIQAPAINRARCFLCASAYNAKEGEKYCFSCTSILDQVGDKILLEQLLNSMCMVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDN1</accession>
    <name>A0A183HDN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aha1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5594</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004886">
        <property type="protein sequence ID" value="VDO43682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDN1"/>
    <dbReference type="STRING" id="387005.A0A183HDN1"/>
    <dbReference type="WBParaSite" id="OFLC_0000559201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000559201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000559201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="157"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO43682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000559201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31353" checksum="45D828FA42BC1D35" modified="2016-09-07" version="1">VKVAGSDINYEGHIEIPNLSDENEADEVDITPSVTTSGPHEDQIRHFLNNEVATFIRKQLAIYIRELKEEFSKGLILPTDRAIPQVVSKGKTTVGKQHVDKKAFQNHVVTSVDNDLTKSAPLIIPLITSPKFVFLNKLVVSVISDVKNLSFMESFKVQPDQLWEVLTETELVKKWSNNEAKLDLKPQGAFTLFGGMVTGEFVKIEPCKELGMKWRLKTYPSGCFANLTFRLKDEGDSTTLEVDVKGVPTTEYDKTENGLHRFYMQNIMRTFGFGAHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HER6</accession>
    <name>A0A183HER6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5977</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005432">
        <property type="protein sequence ID" value="VDO44996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HER6"/>
    <dbReference type="STRING" id="387005.A0A183HER6"/>
    <dbReference type="WBParaSite" id="OFLC_0000597701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000597701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000597701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO44996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000597701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13782" checksum="9CFE0846509A754C" modified="2016-09-07" version="1">MTMKRRNHGRNKKGRGHVRPIRCTNCGRCAPKDKAIKKFVVRNIVEAAAVRDISDASAYDSYALPKLYHKLHYCVSCAIHSKVVRNRSREARKDRNPPPRFGQRGGMTGDRFPRPGAPNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFK7</accession>
    <name>A0A183HFK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6267</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005858">
        <property type="protein sequence ID" value="VDO45968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFK7"/>
    <dbReference type="STRING" id="387005.A0A183HFK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000626801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000626801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000626801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="87"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO45968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000626801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29086" checksum="B6BC39E1DBF6589C" modified="2016-09-07" version="1">MLRYNFGIITASSWTWPLRQASTFSGSGLTSEKFMKNPENEPVLTYRKGSTERIALEKAMSDIAGTITNVPLVIGNEKISKNLDKKQIMPSDHQKVIARFAHATTEQIKEAIRIGLSAKHSWERKSLRERADIFLHAADLCAGKYRMKLNAATMLGQGKNIVQAEIDSACELVDFFRFNAKFALDLEKYQPISLKNVTNTMTLRSLEGFVAAIAPFNFTAIGGNLATAPAMMGNAVLWKPSCTAILSNYVIYEALEEAGKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFT1</accession>
    <name>A0A183HFT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reticulon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6339</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005975">
        <property type="protein sequence ID" value="VDO46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFT1"/>
    <dbReference type="STRING" id="387005.A0A183HFT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000634201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000634201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000634201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000634201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12061" checksum="322C905568F62EE2" modified="2016-09-07" version="1">MLKEAEEGKGKSKSSGTPDITEFKISDLQKCGKYVTFLTLVYFIMTLTQICNLLFMTFAGSLSISLSYTQNRKPKVEDFCAKKYPDYVSAKACNATNCWVTTNESGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFW8</accession>
    <name>A0A183HFW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6380</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006027">
        <property type="protein sequence ID" value="VDO46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFW8"/>
    <dbReference type="STRING" id="387005.A0A183HFW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000637901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000637901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000637901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000637901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14427" checksum="3184ED63B431A901" modified="2016-09-07" version="1">MAFKELGKMCAQHLQQGSDKTQTKLGVLHQAVAVITGLEEQEQNEAILPCQSVLVANQPSSTNDSTIGNLNQPSSTIIAHWVRQRNLNPKAACLKRREEEKAMPPITGYVLIFYKFLKHYFHYFFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG05</accession>
    <name>A0A183HG05_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6417</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006086">
        <property type="protein sequence ID" value="VDO46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG05"/>
    <dbReference type="STRING" id="387005.A0A183HG05"/>
    <dbReference type="WBParaSite" id="OFLC_0000641601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000641601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000641601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000641601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22150" checksum="94704E33C6A60F5A" modified="2016-09-07" version="1">MRLTNPTERQVCFKVKTTAPKQYCVRPNSGVLSPGEMCNVAVMLQPFDASSNVEMEHTKHKFMVQSIYAPSGDLSLDTIWKNAQPSELMDSKLRVVFEHPLATEYGGDKTPPRVSLESKSTNSGYAANMDAEVRRVIEEKNRMEAAKVSLERDNNSLKARLAALEAMPQVTGNQTIEGGITVIQVSCCIVEIYASASYSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG92</accession>
    <name>A0A183HG92_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6506</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006213">
        <property type="protein sequence ID" value="VDO46763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG92"/>
    <dbReference type="STRING" id="387005.A0A183HG92"/>
    <dbReference type="WBParaSite" id="OFLC_0000650301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000650301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000650301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO46763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000650301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25880" checksum="86BD054DA0AF5A36" modified="2016-09-07" version="1">MEKKRGMRVAEDEYICINCCHPSSSLFLKYSDNGIRLTPCSNCGKAVDVYIEYDIVLVIIDLMLQYIGAYRHFLMNTSNRVFFTFFECNKWIRQRIMSGNENAYDLEWKFYECLLQSWLEMASFMIVLTLLSSQTSTKFSINKMVQTFCVGSYGNVFAVLSIIWHLHLVWSYRMLTELFVFISHVQTQRALCSGTLIRSILVVLTATVVSRSIGLLMDSYCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGR4</accession>
    <name>A0A183HGR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pathogenicity island protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6675</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006491">
        <property type="protein sequence ID" value="VDO47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGR4"/>
    <dbReference type="STRING" id="387005.A0A183HGR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000667501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000667501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000667501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000667501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8484" checksum="33B4C343AC52E353" modified="2016-09-07" version="1">MIIKGVSSINTQLSDVYELLKSDDLIPEISNDYDEAVYIILLKEQAQVDSSIIASYADSITDMQKTVKQMLSQLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGU5</accession>
    <name>A0A183HGU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6706</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006538">
        <property type="protein sequence ID" value="VDO47605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGU5"/>
    <dbReference type="STRING" id="387005.A0A183HGU5"/>
    <dbReference type="WBParaSite" id="OFLC_0000670601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000670601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000670601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000670601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40577" checksum="FF05DE515354E845" modified="2016-09-07" version="1">MINLDFGDILPFLQMCVDFVFSSDFATDAVLEQLLISAFVYLAVNAENSAEIMQLILEILFSDNIVIAHRCKCLMSAVISNYCVVNVQNHSNLFSFIGGLTPATLADKNTTSAEGFNMGVVIQSAVNGFKPAIVYELENQINKEKGIPVQLKPLSDFEDFNRKMAWIGQLLLALVSRFDICNYDGVRCLAPAQTILFLMGQHAPDQLTDLIDYLISGLDFNKVQTERTMKAERDQVILRLIYVILVQCTSHNWPSRNNRKSSEERLHQVTVPKSEELTAILSAANISAVAPAGSIDDGDDAEAGGESDLEQMEGTELAGDISSSSRDATPQQDDIDMNVIPQVESKEHEESSVTPEPQVALAVKVARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHJ6</accession>
    <name>A0A183HHJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006952">
        <property type="protein sequence ID" value="VDO48664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHJ6"/>
    <dbReference type="STRING" id="387005.A0A183HHJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000695701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000695701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000695701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000695701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32580" checksum="EE6593FD3ED9CBE9" modified="2016-09-07" version="1">MELINLMIIRVNTTTSMIHVFRITFIPVHVKIFNRVPYLLNNTDNLLLKRENLFAWTFPKSFPSSQLIYHVIEPPKFGILSRRIEKNRNRRIGVSSNFTQKHIDDGDITYKMHFVQYSIVNDFFTFRLIAPSVTSEEIRFEITFIPGRGSVQLINRTVIVDEGGIQKITNESLSLRTPDSSNFVFIIGNAPTYGNIVLKRATGEQLKLVDGDNFTTSDVNNGNIFYKHMDEENRIDRVFLLAESAYQRKSRISFWLTIRLILKNDNIPRLTGNNILQVCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHQ1</accession>
    <name>A0A183HHQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007048">
        <property type="protein sequence ID" value="VDO48878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000701201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000701201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000701201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000701201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8469" checksum="6E54EE547EFAE90B" modified="2016-09-07" version="1">MNHFGLFQTSNEAEMVDHLKQENFTTQLSLLKTNQHQKFASSTRNKTDNSKKNERTKNSSNMILCNKQFEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI52</accession>
    <name>A0A183HI52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EamA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS7165</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007299">
        <property type="protein sequence ID" value="VDO49649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI52"/>
    <dbReference type="STRING" id="387005.A0A183HI52"/>
    <dbReference type="WBParaSite" id="OFLC_0000716301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000716301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000716301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO49649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000716301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23463" checksum="7F43D95A939EB3D3" modified="2016-09-07" version="1">MVGLFGSIISGIQLAALEHHELASVNWSGTIVVFYLIFIASMFLFYSMVSVVVKKSSALMFNLSILTADFYTLVFGLFMFKYEFHALYFVSFALVMIGSLIYSIRETERRDPDEPHNICCLICHCCTDDDNGTDDDNQSLSIPQQYFAQTSSVRIGSGIGTANNTAMYGATAYPKTTNMKHCPVHGRQVPFLQQQQQQQQPIDTLETYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI63</accession>
    <name>A0A183HI63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AMP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7175</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007311">
        <property type="protein sequence ID" value="VDO49694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI63"/>
    <dbReference type="STRING" id="387005.A0A183HI63"/>
    <dbReference type="WBParaSite" id="OFLC_0000717401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000717401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000717401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO49694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000717401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44994" checksum="E6121E8F061302AB" modified="2016-09-07" version="1">MIGGICRCLRRISSSSMATVTTMKQGISVAEYTQRRSNLIAKLRHAVPEIENKPLVVVLRSAVRHFYAPDVPYPFHQCSYFRYFTGLNQPDAVLIIAAEAEQEPKSILYIEERSEKQELWEGPGLTANEIANICGLDEIKERSQLIPDLQTLIFNTIGCIVSYDTTTLHTIRDGLPEVLSTYDKFVPVREHIDALRWIKSSAEQDLMRRTCSIGAHSMNAVIAKSRGISNENEIIGQLELEVRRRGAASLAYPPVVAAGNRANIIHYLDANKAINDSDTILVDAGCEYEGYSSDITRVFPVSGHFNVPQRAIYDALNDVQSRLLDYLRQTESLRLNEIYLTMIEYIARNCSEIGMFTSNIGVEELLHVSSLLFSNFHKFYLIRYNQYFNLFISFMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIT1</accession>
    <name>A0A183HIT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007696">
        <property type="protein sequence ID" value="VDO50792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000739201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000739201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000739201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000739201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16565" checksum="D5CF3EDBBA33A7C9" modified="2016-09-07" version="1">MFCIKNQNLQLLKCPVVPNKNSYEIVSEGPISIWFYGKREKKTDRYAFQIMREVVPMLFISFNYQISIIAQSTLPIYIPSDINIVVNGKKVQLYVGEGCQITNKDKKKSYRTISTGQFEIPKSQIIVLHCADVIRRFQDLIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIY9</accession>
    <name>A0A183HIY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PMC2NT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7452</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007799">
        <property type="protein sequence ID" value="VDO51084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIY9"/>
    <dbReference type="STRING" id="387005.A0A183HIY9"/>
    <dbReference type="WBParaSite" id="OFLC_0000745001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000745001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000745001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome-associated factor Rrp6 N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000745001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29414" checksum="4C4BF8F0FB4F2AA3" modified="2016-09-07" version="1">MSEEQSTSNPNDILDSVKNVKLCAVRAVGEANALPMRTEGYELYASFPAYANLMMEQQRRITIMLREVLQNAGCRIPIPAKISDLDEFLDRIVEANDSICERAGILLDLLQKARRMEEVVVPQQILDAESTAASEQTLFERQGRYTALLRRLPGYKDKQLSSAVTSAVPLLTPREKPQAVFGIEVDNSFAEFKPKLREKHHAMKNPVRNLEIVDNDNDYAKSTIWSNDEGASLHPYQKELSHFKIPERQLIVGMTEPLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJB6</accession>
    <name>A0A183HJB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008006">
        <property type="protein sequence ID" value="VDO51677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000757701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000757701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000757701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000757701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8894" checksum="403E37EA7486562D" modified="2016-09-07" version="1">MSHVYSDRIIRPGYDLEQEEQPRRLPGQQIQQPQENNLQDLRHCQQWLQNIVNPRLSHKYRVERLLNENSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK11</accession>
    <name>A0A183HK11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008419">
        <property type="protein sequence ID" value="VDO52688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK11"/>
    <dbReference type="WBParaSite" id="OFLC_0000782201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000782201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000782201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000782201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17550" checksum="7B042494BA65B3F3" modified="2016-09-07" version="1">MQLFVFFRMEGINLEGFIYDCSPNSIRTIYCSVIGEVCIDETTEIINRNRKINIGMWCKFKASRKKTGEWFAQKILLMAYPRLKCIIKENECIVKGTAVVCNINRDGAYLWNDYIGLIAIEGKMINQLKSLTAVEFQAVPSKKNGISAHFMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK45</accession>
    <name>A0A183HK45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7857</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008483">
        <property type="protein sequence ID" value="VDO52861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK45"/>
    <dbReference type="WBParaSite" id="OFLC_0000785601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000785601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000785601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552553" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000785601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9013" checksum="BFF75B234EEE4B9B" modified="2016-09-07" version="1">MNPFGDIMKGYNLLFLLVLFSENLIEISLGSPHFMRVTATEQSTLKWGMIDACYWHAVRSIRTSSLSVPIHPSVINRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKU8</accession>
    <name>A0A183HKU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8112</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008919">
        <property type="protein sequence ID" value="VDO54051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKU8"/>
    <dbReference type="STRING" id="387005.A0A183HKU8"/>
    <dbReference type="WBParaSite" id="OFLC_0000810901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000810901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000810901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000810901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22025" checksum="64352541009B2583" modified="2016-09-07" version="1">MKWHELFPCSGHYESYPRPMYCSGLLKFTSGEMIYTPMIYTPAVDVIYQSASPYFSDSFSDLLEILSLMIGEDMKVVYTFFLMLEMKCLIPDIFNDLNEITKNCERFTTCAQVELLGDGPRNVEVQMHRISENVARADFKFLAHIGSIPVDVNRTSRTPTKRRRKKSCNHTPEKRSKEQRSQSLTTENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL71</accession>
    <name>A0A183HL71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8233</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009149">
        <property type="protein sequence ID" value="VDO54695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL71"/>
    <dbReference type="STRING" id="387005.A0A183HL71"/>
    <dbReference type="WBParaSite" id="OFLC_0000823201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000823201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000823201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000823201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10417" checksum="750F09124A3BC851" modified="2016-09-07" version="1">MFTKLVLITVKATLQKQSIFPKKIDEAMVDIGDAISTAKDIQYAYHCHVPMSDGDELNKDFKAELNATSEYNSEISLMSKEGLSDVPREEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLF9</accession>
    <name>A0A183HLF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009296">
        <property type="protein sequence ID" value="VDO55089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLF9"/>
    <dbReference type="STRING" id="387005.A0A183HLF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000832001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000832001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000832001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000832001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8320" checksum="3F9CDBEF6A4525F3" modified="2016-09-07" version="1">MRIFKMKILLIFEKSNLDPTLTALGLPPYPTLSANTEASKVEEIRRTVYVGNIPKDCAGEEVMKFFNDSIGEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLM7</accession>
    <name>A0A183HLM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8387</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009438">
        <property type="protein sequence ID" value="VDO55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLM7"/>
    <dbReference type="STRING" id="387005.A0A183HLM7"/>
    <dbReference type="WBParaSite" id="OFLC_0000838801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000838801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000838801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000838801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10495" checksum="3F19FD9562F302D6" modified="2016-09-07" version="1">MGVECSTVEANFLKERSEFNVHLSSSEEFTKRNCSSWETMVEEIVAITGGSGFLAQHLISCLQQTNHCEVVIVEIRTIDRNSFSKFLGIVTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM35</accession>
    <name>A0A183HM35_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P protein subunit p29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8545</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009766">
        <property type="protein sequence ID" value="VDO56194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM35"/>
    <dbReference type="STRING" id="387005.A0A183HM35"/>
    <dbReference type="WBParaSite" id="OFLC_0000854601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000854601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000854601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO56194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000854601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17496" checksum="4D62AE4F6726D1D3" modified="2016-09-07" version="1">MSANASTSFEPLNPHKVFILEKRIKKETKIRRQPVKNFMKRKIVKSDMKKLKYSQFEPLYELWCDYFSTLVNGSGSQCDARVLRADYHGCMLMVAEAANPTQIGICGIVTRETRQTFMLITKQDRLISAFQPSLRAKKILRNRSSVPFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN41</accession>
    <name>A0A183HN41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8904</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010456">
        <property type="protein sequence ID" value="VDO57947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN41"/>
    <dbReference type="STRING" id="387005.A0A183HN41"/>
    <dbReference type="WBParaSite" id="OFLC_0000890201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000890201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000890201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO57947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000890201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11094" checksum="A8127E21A8D88053" modified="2016-09-07" version="1">MYCSCWGEGQSCSLKEIADLLNEEEKAQLRDSDGGLQTFLKNQHQIFKVVKGTVSIRNWAEEGKRRVEGKLRTSDCWFHKYFSGGCPLSAEDCSYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNC6</accession>
    <name>A0A183HNC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8987</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010606">
        <property type="protein sequence ID" value="VDO58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000898701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000898701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000898701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000898701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15394" checksum="3C7D9B5D83199506" modified="2016-09-07" version="1">MVPQFYLSDGAKRMVGMDQNGYIIQDNRDNRIVGNQGNEIATNNDAEGRQSDDAVPDRFAALKAITTLLRIPGVQQVAIIQNNNRMPDNVIVTPEIRTDEKTSNLDESPIMSSTKSLTQPQVPYVPQMEARDWEMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNE6</accession>
    <name>A0A183HNE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9009</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010647">
        <property type="protein sequence ID" value="VDO58365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNE6"/>
    <dbReference type="STRING" id="387005.A0A183HNE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000900701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000900701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000900701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO58365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000900701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28283" checksum="59E5B91E9FB769C7" modified="2016-09-07" version="1">MIGPETLLLATRGAGFNARVRDYRRELWGDGAPLVTQGYLGYRNQDITVRERRRFTDLIREDENIAKSVENLGRDMRGSHLGAIRRIRSDISKAIPAASREDGSKEFHFAFGAIFRNRLKDVAFVENGSTVIFKCTVIGNPQPTIEWFFNESLIVDDNKHKIFYENGLCQLTIQNIDLTDLGEYACVASNEHDTDRTCARLIAGDTPAPPGRPEVELSSDTEVFITWEAPQMNHPLECFMYKLEVRLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC6</accession>
    <name>A0A183HQC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012153">
        <property type="protein sequence ID" value="VDO62473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000968701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7802" checksum="E8716449B9E0AE94" modified="2016-09-07" version="1">MREAVILKIAVGNIPRKKNKVEYFALGIMLFSCEYVERQAGHNFALKQNDGPKFGFFSDILDILLIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV95</accession>
    <name>A0A183HV95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maestro heat-like repeat-containing protein family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11399</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016418">
        <property type="protein sequence ID" value="VDO76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV95"/>
    <dbReference type="STRING" id="387005.A0A183HV95"/>
    <dbReference type="WBParaSite" id="OFLC_0001140701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001140701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001140701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001140701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19663" checksum="2C1932658CE00D43" modified="2016-09-07" version="1">MKIRIRIRIFQAGEPEIELCKRIPNILAALLQFLAAVVDTQYPVLMKEKDGVKSLIITPELRRLSSTPAALASQALRSLFLRTLDDAIVEKMNSERAWSDCVDTLHFTNGIAVLTRSLSEHRPEWIRPLVTLLIPRMQSPSDAYRIAATAVLSALTKRYEYQYYVIFVLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVM4</accession>
    <name>A0A183HVM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11536</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016758">
        <property type="protein sequence ID" value="VDO77178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVM4"/>
    <dbReference type="STRING" id="387005.A0A183HVM4"/>
    <dbReference type="WBParaSite" id="OFLC_0001153601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001153601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001153601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF12">
        <property type="entry name" value="CDC42-INTERACTING PROTEIN 4, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO77178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001153601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14076" checksum="AFAF8F3CDB443FB3" modified="2016-09-07" version="1">MDLSRADLERAKNNAMQRTQICEDAKQNYAHALQAANQQQHQHYNQLLPQLLERLRAVDEERISETKSLILQGIEAETKVMTIIQRCYEDMKKAAQSISPSKDSASVVEYYRFVFLNFLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVM5</accession>
    <name>A0A183HVM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11537</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016763">
        <property type="protein sequence ID" value="VDO77183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVM5"/>
    <dbReference type="STRING" id="387005.A0A183HVM5"/>
    <dbReference type="WBParaSite" id="OFLC_0001153701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001153701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001153701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO77183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001153701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14186" checksum="455D8DE57A041C37" modified="2016-09-07" version="1">IFFYTILTKESFNTVYFVPYKTTKFSNKRFIRYKTTIKFRSTKLLAQTTLRNILGTKTLTEMLSDREAISLQMQITLDEATEPWGVKVERVEVKDVRLPIQLQRAMAAEAEAARAARAKGIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVT9</accession>
    <name>A0A183HVT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11601</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016966">
        <property type="protein sequence ID" value="VDO77733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVT9"/>
    <dbReference type="WBParaSite" id="OFLC_0001160101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001160101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001160101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001160101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7692" checksum="3DB0FBB03B1A2FC8" modified="2016-09-07" version="1">MVYMWGGICARTRNLCSKIYCFDPGTFLLVIFAKIYFQILSNKTFSKLTQFFFINKINFTNLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW13</accession>
    <name>A0A183HW13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11676</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017170">
        <property type="protein sequence ID" value="VDO78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW13"/>
    <dbReference type="STRING" id="387005.A0A183HW13"/>
    <dbReference type="WBParaSite" id="OFLC_0001167501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001167501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001167501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF819">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001167501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9769" checksum="FDBE284166EAAA59" modified="2016-09-07" version="1">MMEYVVAHETGHALGFWHTHQRPDRDRYISINWNNVMDEATASFMPFRSMIQAFGIRQVSFFSCKFLNRSKCSAYRVFIFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWA5</accession>
    <name>A0A183HWA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS11767</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017454">
        <property type="protein sequence ID" value="VDO79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWA5"/>
    <dbReference type="STRING" id="387005.A0A183HWA5"/>
    <dbReference type="WBParaSite" id="OFLC_0001176701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001176701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001176701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF91">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001176701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8705" checksum="85C3B1B788FDA22B" modified="2016-09-07" version="1">MFIMVGAWHDAEKIYPGTDNATLKARMVNALSESAVAIFITSFTDVLSFAIGCFTDIIAVRGFCAMTSACMFFTFLYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWP7</accession>
    <name>A0A183HWP7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS11908</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01017821">
        <property type="protein sequence ID" value="VDO80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWP7"/>
    <dbReference type="STRING" id="387005.A0A183HWP7"/>
    <dbReference type="WBParaSite" id="OFLC_0001190901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001190901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001190901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001190901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20987" checksum="E643299CFD509138" modified="2016-09-07" version="1">MLLKSKLNNLNEISPLNFSPSSTGLLDPSTSDGRVIFFLPWQRMTVAGTTDAPVPLTFHPSPSDVDIEFILREIRSYLSKDVSVRRGDVMSAWSGLRPLVRDPNKNDTKSLARNHIIEVSKSGLVTIAGGKWTTYRHMAEETVDKVIEVANLKPIRKCVTAGLLIEGAHNWDPLLYIRLVQDYGVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX81</accession>
    <name>A0A183HX81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12094</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018329">
        <property type="protein sequence ID" value="VDO81870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX81"/>
    <dbReference type="STRING" id="387005.A0A183HX81"/>
    <dbReference type="WBParaSite" id="OFLC_0001209301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001209301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001209301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001209301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9675" checksum="82B67EB2217F7D75" modified="2016-09-07" version="1">MKCTESCPGEGHEDLVAKTVLSAYICKDKLEEFRLVKECMERQDATDSINKCSTECGHPSDATIQLDSSAAALVNPFAFNDNTTQICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXD5</accession>
    <name>A0A183HXD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12148</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018486">
        <property type="protein sequence ID" value="VDO82301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXD5"/>
    <dbReference type="STRING" id="387005.A0A183HXD5"/>
    <dbReference type="WBParaSite" id="OFLC_0001214701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001214701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001214701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001214701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15013" checksum="51A8310E9CC4AACF" modified="2016-09-07" version="1">MIILLTLVLSTPYFKLPNDSRATPTSSNIVSDSDAQRHHTKVRSAVAFYDGLVESGQMVSPTVFPGPRDSSLDQQSSMRSSVISDGSWMDLQLRSPLSSETESLYSEQSFDCSKEATGDSNEKTLVPEGNFESDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXL4</accession>
    <name>A0A183HXL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12227</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018722">
        <property type="protein sequence ID" value="VDO82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXL4"/>
    <dbReference type="WBParaSite" id="OFLC_0001222701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001222701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001222701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001222701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="10277" checksum="393F6E297195A7BD" modified="2016-09-07" version="1">EEEEQEEIDSKEEEEETKIEEEEKESKPDISEKEELESEEEAMLEEDEEKKVEEDKEEKKSKNIDEKKEMKKDLKEERLEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY85</accession>
    <name>A0A183HY85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12447</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039845">
        <property type="protein sequence ID" value="VDP11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY85"/>
    <dbReference type="STRING" id="387005.A0A183HY85"/>
    <dbReference type="WBParaSite" id="OFLC_0001244801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001244801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001244801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF185">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001244801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64993" checksum="F6E8F2AF438C52FF" modified="2016-09-07" version="1">MEGYLAVISVILSLICTFGMLFRLGVPFNPVSCTVPFLILAVGVDDAFLMLAAWRTTDRSLSVEKRMAMTMSDAGLSITVTSITDFGCFGKFLNFSGTTLGYFLCPIPAVSDFCLLTACGMLMDYLFQITFYASFMVYGGRREAEGGLISYCWRPRSKGNVTSHNMQQPYIHRWFRDTYAPFILRKNVRIVSLLVYLVYAFLAIYGCVSIIVDISPGKYIRDDSPMQPFIHLADKYIWADNVMPTFHVMNPPDFRLAQSRARMNELIYRLEHTAYSIGRVSTNFWLWEYQRFLNDFPEVNYTKSFYEKKYLIDFFDQSDNQQYRAYVKMKRNVTDGEPCVAAFGFQTSFYGLDSWEKRHNELYRWRAMIAEYPDLDIFLAGIFSPFLIDQRKSIAPSSMQSIGSAISVMAILSILFLSDKQSVFFMTWSLLSISMGVCGGLALCGSDLDSVSMGCIVMAIGLAVDFSIHICYRYHRSSEQTADEKVRESLMVVGWPVVQAGVSTAFSMMVLPLIPAYLIRVFFQTVLLVNFIGLTHALLWLPQLISSLDPCERIPLRYRYPLKEYEPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYP1</accession>
    <name>A0A183HYP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SHR-BD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12603</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039880">
        <property type="protein sequence ID" value="VDP11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYP1"/>
    <dbReference type="STRING" id="387005.A0A183HYP1"/>
    <dbReference type="WBParaSite" id="OFLC_0001260401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001260401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001260401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055929">
        <property type="entry name" value="DUF7506"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057139">
        <property type="entry name" value="OB_DEPS-1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057143">
        <property type="entry name" value="OB_DEPS-1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057147">
        <property type="entry name" value="OB_DEPS-1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057144">
        <property type="entry name" value="OB_DEPS-1_6th"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24338">
        <property type="entry name" value="DUF7506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24343">
        <property type="entry name" value="OB_DEPS-1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24342">
        <property type="entry name" value="OB_DEPS-1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24339">
        <property type="entry name" value="OB_DEPS-1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24341">
        <property type="entry name" value="OB_DEPS-1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-granule-associated protein DEPS-1 first OB-fold" evidence="5">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="P-granule-associated protein DEPS-1 second OB-fold" evidence="4">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="P-granule-associated protein DEPS-1 third OB-fold" evidence="2">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7506" evidence="1">
        <location>
            <begin position="272"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="P-granule-associated protein DEPS-1 sixth OB-fold" evidence="3">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001260401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62787" checksum="0FEF7A7D7068903D" modified="2016-09-07" version="1">MYGVVVTPPLNEAEIMYAIYVDEKFPLLFIKRTPVTNRAKLTKIERKNLDKAEKIRSLTFGDWIEFEESDILEGCIEKYAKIYPLNPCRSNGDHLQIESTCVFSPLAHGWENECYCELFGKVRVDPELRNCFLADVAYRCWISVEVTRISSLNVELGEYIDVSEEQNLVNEAPWNREDPRFLTIISSDSGESDLDLMEAIPQVSYPYEIYDMQGVLVSERNVYSSDYPDVKIALAYVKRERHTPFGSCIYFNAFYSIPLRLYVVRSYRLSEKKSLTTKPFEFGSLFLLEVHAKWEPDLPMGYLWSKDKDLGLIHDADGLLLPILLSKNPYAPVCVYVADTGPSRLSRFTVKDLSGMTATKANAVINNYAELSDDGLILGDGSVLASHYLCLKIRFDSSSPKGWDKLVPGTWIKFTARNPAGMPDFKINTWNSSNNPHLMQIRAVPTCSGYAFEARGYFDQELSAVKSTIFGFIEIPREKRSLMIPKDKGITILWVREDKRNEKARFVLHSIDAPQIVDVEKDMEKKSSQSLMNNVKQCCAAEKVSLKYCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYS4</accession>
    <name>A0A183HYS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039889">
        <property type="protein sequence ID" value="VDP11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYS4"/>
    <dbReference type="WBParaSite" id="OFLC_0001263701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001263701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001263701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001263701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9565" checksum="7D8A56A22397E02C" modified="2016-09-07" version="1">MMSDNSEWQPFGHIDVVQLVICRSLDWINNYSQLPPLRAIVLSVQLSLQIKDAPPHCFIIRNTSNYFVMCVETIRSDHKVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZC7</accession>
    <name>A0A183HZC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12839</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039951">
        <property type="protein sequence ID" value="VDP12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZC7"/>
    <dbReference type="STRING" id="387005.A0A183HZC7"/>
    <dbReference type="WBParaSite" id="OFLC_0001284001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001284001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001284001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001284001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23117" checksum="EEAEB7710C14A774" modified="2016-09-07" version="1">MGCECNRGDIAPIEGDCTAYYECVDEHYKLQLCPTNTFFNPTLKRCHADYICPNRAHELPTTSPLSCKYSEFRADKTSIGDQQHFERRFCPNGKVFDRQLNRCVLDDARNRCQQLAQQSFESRNIAVGLTCIVVNFRNFTYFTKIQESSGPSGYSADPTDCRRYYQCAQGRWIRMQCPSNLVWNPAATVCDWPKNTLLSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0P8</accession>
    <name>A0A183I0P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040138">
        <property type="protein sequence ID" value="VDP13423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0P8"/>
    <dbReference type="WBParaSite" id="OFLC_0001331101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001331101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001331101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001331101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8296" checksum="9C0F6FBC6B11787F" modified="2016-09-07" version="1">MTLPWKCPPLRPYQQLGSIIISYHHPPLYPPRNLLILQSSLQLLIMSINHAHIVITLVALSATTKIRGGKQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0U3</accession>
    <name>A0A183I0U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAYSvFN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13355</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040159">
        <property type="protein sequence ID" value="VDP13531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0U3"/>
    <dbReference type="STRING" id="387005.A0A183I0U3"/>
    <dbReference type="WBParaSite" id="OFLC_0001335601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001335601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001335601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SAYSvFN" evidence="2">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001335601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21167" checksum="A79E833CEB795743" modified="2016-09-07" version="1">MKCVEERLAEHRRKESAACDNSKISNDTIYEEKFRSNNGIAVHSATVSKFINILLKPIQLWSYFCCHWPRSCTAFAILLWIIVQWYFTYIEFGLVFFIFSLFFFLFINLGRRKSNELSAYSVFNPHCERLPGTLTAEHFERDLLKRKILGYRDILEFERSIDSCPPVNNDWKLLISSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Y1</accession>
    <name>A0A183I0Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13393</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040178">
        <property type="protein sequence ID" value="VDP13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Y1"/>
    <dbReference type="STRING" id="387005.A0A183I0Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0001339401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001339401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001339401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001339401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15468" checksum="4EF926D8019AF962" modified="2016-09-07" version="1">MEDLNLQMYLEPPTEDITLHEFQELALNRLRVLKVVEQVKDRFPRGTEAINNELTKQLLKMMPIACGCCPFEELESERKRDVISHFILRLAFCQTPEQTKWFIQQEVDLFKFRFQVVRFLQFLFKAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Y2</accession>
    <name>A0A183I0Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PWI domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13394</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040178">
        <property type="protein sequence ID" value="VDP13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Y2"/>
    <dbReference type="STRING" id="387005.A0A183I0Y2"/>
    <dbReference type="WBParaSite" id="OFLC_0001339501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001339501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001339501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000004">
        <property type="entry name" value="RNA-binding motif protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="353"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001339501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52656" checksum="CF1816327B3A8143" modified="2016-09-07" version="1">MEKDDDKYSSRHRAHSRSRSDSRDRHKSRKRSRTDSERSDVKKDRDSEDSDEQKERRALRKQIREKEIAYADRLRKWEARERRQAKLYERDEQREKQRKRDMQKEAKKLKHFLEDYDDERMDQKYYKSSSLFQRRRDFEREREADAKDRQREQQEIEELKKQILAENANVENPDEEARKRHEEQEEALLRKLRADSGSPNPHRPLGQKPLPSEPEKDEESEESESDSESERSGEEAVNMEKPEKRSSWKAVASEDTPVANSPVVSVASPSIMSSSLASPAVVRTDVITPARPSTSSHLNGIFGFEENDEDAAFRKKKLKPFEITEEDRIQAMTSEERKQMIKDLIDRIPTAKNDLFAFPINWNYVDKSLVEQRVKPWVSKKITDYIGEEEASLVDFVCEKVTSKTDPQKILSDIAMVLDDEAEVFVVKMWRLLIYESEAKKLGLSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2E9</accession>
    <name>A0A183I2E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCA-2_OB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13911</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040463">
        <property type="protein sequence ID" value="VDP14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2E9"/>
    <dbReference type="WBParaSite" id="OFLC_0001391201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001391201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001391201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1840"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001391201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2142" mass="241951" checksum="0489C2338FF5DFD7" modified="2016-09-07" version="1">MIPSEKMVSNKDKNSTNYFGLGSDEAFYGVESDSKISLQIKSAENNLEGVIIAVDVQRFPGNSVHELLVSTVSDDNMQQVGSAVIADEIAKDVVSTERVLSVADAENSENTIPYIHIVSPAVVQLAEDMVSPENVESFKNIAPSEQIVLHENAETILPCTDIAIVTECILSDEDVTSAKNTVAAENMMGHFWKSMQIEESTEFSIFESNDDDSFVSDGVIGEDQKVLTKERLEYIAYINHMAKKDLCISESVKDEDSQFELNHEELEGIVICANMDREAFDQSEMPKVVQTKSITLAEHTANEKLNEILPVVKLEHISYVSKITRHKFPLFDYCKDTSDSQKASLLTSLNDKLELTAEELEHIAIPCLAEKSFSEFQDLKLQALQRQSISKNQNEVRFDCNVETGKERYEFFLNGGQSVMNSAVLDAVEVYETGHEQLKDDKSSMLLHGDLTVPLDEMSNIDESHKKKNLIQIQKNAQVDQVSVDSRHSIGNPDIRFCGPVIQRLYPETEIAYTKFQRFHPSHSDTYINSPPRGLSAEETVILKSVKVSRKPRNVEDEYIELANQESDSEDFEHSDRTGRNLNLFSFKPCPTVSSITGVPSEVASGVVLTDESVVCDQLALSGTLIEESLTHYNIPQVIRIGSIAGTDYFEEKQHEENGIGHINMLAKEGSQNEQIGLDDGILKSGSGQFSSESLSHWRKEFAFEGPRERCTKQKEQQRIQSIIDKSMIESWVDESRIRIRRNEEFDDDTNNFSKISCKCNEIIGGERGTMLIKGKSYPRIQPNGKVEFSLEHSNHCLIDGFHVTSTVTYTDRLYKKMARNLRFSQKIPHYGRGNFWKTFNDEKEYSAKRDIEGMKPPFTRASSVFVVYTDQNLLTSQSTLLGKEGKKHSAEKTVIRRDNSEVSRSNTTSKVENTTDIGINSIERVDSTFDIISISPVSQGGWERSRKTCSFSGSLLSHSMFTKVENGEGKESLKRSPTWLLKNEKPRGTHQMTVFERCERESIAGDGSLLHHADCLMRLNFFAERITEQIAELAAVELGNRFRAELNPRASHRQGNALSQKSSPDGRNEFMDLLRRTSGASSNGLDMSTKLPDSALAGLSSEERDHIEKVLSAANRRSRSSQSTPTASRQSIYKLPDMNDFELCERIHIKGVIEKAGKGAFPFVIKITKADSVKESSMDAVDEEKSDNTVNQMTSNTNELEESVDGNKSRVLLETSIESISLSERLAKQQNEQIVGKITPETNTVKLGQELTSDAKVHFQKNRRNEEISCGISDAEMKHIQKVTEAAVMMEDDIQWMNWPRSDHQIVENLQNNTAINSLTESKTAEKVNMSVGSNMEWESEPSKKDVLTRVSATGRIEPGKIMETKVIYEIHHEKVGDSGTNAASSMGDTNSLQVLPCLKSTVIKMATSEEDFNRAKSGNIGMQTIKNLQNYERLEKKLTEEKITHIKELKEQINHPGKLENPILKEVMETKIAGLNDEEFAQIRLVNERAKQLEKLDEFNTREIQDICSTEKELEQTRAAGERAKKLQPVDRSFPGEFKTDKRKQGKEDKLLQIKALEKRAKEMESFATLRTEKTTIVDDLKENKGIIPSRKKTLVCTVEGEAKHLQNGILEKKEAGTLQGQSKENYILTEEELMQIRAVEQRAKQMEGFYIFEKQSTGILEKRKDSDLKTNGLLTEEMYQDHLTKEELEQIKEEERNAILQLEMTVLERFRAEDEMTGKTKKTEPQQKDVALSETAFNKFANMLNPVKNSVITMLPFKRSADETKFFQNTASIDNLSKANGQNMEKSMQAYPENQKFETKIPTANKTNRTYSSEVLITTKNLASEQTANRYDENQDSEYISSSESSNFGPGTSDEDEEIDKNSVKSFDLFPETSPRFTNDNDLPKVKEPSAKYNIIKSTDLSLEVIPSSTHMKLLPHSKTKVFSHRIQYSVINEENADRFAGLTNEEIEHIKMVDLQFKLGNVENVSKVSIHNDDDLEVEHDVNSANELIVNAEVNKPQSKESIIDERRPKALHIVNVDDKVKSDIHASTESVESKKDILHSATEIDKLVEQSVKRDFTANEQSESWQSAHAKRDIKVKSLEELGREANIGKWYEERLSLLRKLCAEETAEIPGFDLKLHNLTIITTKEAFFRTLKRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3E1</accession>
    <name>A0A183I3E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GSKIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040714">
        <property type="protein sequence ID" value="VDP16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3E1"/>
    <dbReference type="WBParaSite" id="OFLC_0001426101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001426101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001426101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001426101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15714" checksum="9F0266FCA38AC06D" modified="2016-09-07" version="1">MLSPTISDEQRYRRRRPFRARELSPIWVPSQQTIQILLRKANLVVESAASFHLQVSVAYADPSGGSMIVTRRCQDGHLDVRIIYSREFIVAASASPYALLPPANFRQMVLEMMDIIAKFPKSYYNSKDSSQYRLGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I425</accession>
    <name>A0A183I425_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS14487</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040897">
        <property type="protein sequence ID" value="VDP17285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I425"/>
    <dbReference type="STRING" id="387005.A0A183I425"/>
    <dbReference type="WBParaSite" id="OFLC_0001449501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001449501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001449501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="314"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP17285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001449501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59921" checksum="49B157BC137632B4" modified="2016-09-07" version="1">MDQSCGQVILRGENGCTKQFTFDGVYYMDATAEQIYNEIVYPLVESVIQGYNGTVFAYGQTGSGKTYSMQGDDTIPSQKGIIPRAFEHIFEATATTDNAKFLVHASYLEIYNEEVHDLLSTNHNKKLEIKEHSERGIYVAGLSMHVCHDYKACQRLMKEGSENRHVGATLMNKDSSRSHSIFTVYVEVALNNGSIRIGKLNLVDLAGSERQAKTGTTGDRFKEATKINLSLSALGNVISAFVDGKSKHIPYRDSKLTRLLKDSLGGNMKTIMIACISSSSDNYDETLSTLRYANRAKNIKNKPRINEDPKDALLREYQEEIQRLKAMIQGDNNVHTNSNELDEEREQLKAEFNAAINELRLQYQNEQKSKAKLQEEYAALKEQYERAAEALENDRNLDVGEAKKRLQILEKQFVGGEQANNEALKEQRQIKMKEAEKKMERLAAALNVHSDDPLLHVYSSTQEKLEAITEEYNKAKLKIQSLENDIEDLHGEFELDRLDYLETIRKEDQQVKLLQQILDKVICYNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I495</accession>
    <name>A0A183I495_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF2431 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14557</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040955">
        <property type="protein sequence ID" value="VDP17606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I495"/>
    <dbReference type="STRING" id="387005.A0A183I495"/>
    <dbReference type="WBParaSite" id="OFLC_0001456501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001456501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001456501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP17606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001456501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="53667" checksum="4899CD7DD5CB416E" modified="2016-09-07" version="1">MVSVESLLSEVNTLFEHRLVFKAADELFFGDKMLYHNHSNDGSKKEISGGNRDTDRRKGKRKDQKDKNHSSDMNEKPVGSDGLRNAIASARKTIKQALEDTSDDATSNALTKLTEEVVALKKINDEMRNEIDKLREDFQKILNYAQQLKPCIFSALERVGSRTLILGDGNFSFTLAFARLHPETEICTSVFESYSEYVTKYPSAKKNITELRTNHPCVHILFSIDACLLPKDWAGFYDDIIWNFPHHCGKTNLRKSRQLIRKTFASVGRILLSGRFHITLAKGQSGLDHSSILSKRCFKYRRLPEHRSDSWNIIYIAAEEYFILQQAFIFQSELFPQYTSSGYHNSERSFNHKTGSETLIFVRTPVVTRIKEFLEYENKIFRIKRVAHEWRPFFQRDLSIIYLNATKAAELEKILFLLIEEFCGHALLDFYEVIDLRTYYLGQPNHIYRFIWQSWRIPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I525</accession>
    <name>A0A183I525_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14837</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01041266">
        <property type="protein sequence ID" value="VDP19133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I525"/>
    <dbReference type="STRING" id="387005.A0A183I525"/>
    <dbReference type="WBParaSite" id="OFLC_0001484801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001484801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001484801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP19133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001484801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20516" checksum="61DB467C37F5654C" modified="2016-09-07" version="1">MKWLTFLTESPWVNNCIGEYNQKYFLQFLLYVGLSSGYALSLIVTAWVHHDQYALNGIKGPYEQSVHNAKILHTIFLSIESALFGLFVLAVSCDQIQAILNDETAVEAVQRKGFHNRVAQSRSKITLIREVCGNGKTDDIVVVTMFNFTVRTKRGSVFESITHCLKFDSYMLRNGSKLLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5F4</accession>
    <name>A0A183I5F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thrombospondin type 1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14966</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041423">
        <property type="protein sequence ID" value="VDP19802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5F4"/>
    <dbReference type="STRING" id="387005.A0A183I5F4"/>
    <dbReference type="WBParaSite" id="OFLC_0001497701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001497701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001497701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adt-1/2-like" evidence="6">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP19802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001497701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29874" checksum="3A171E58C90E1BE7" modified="2016-09-07" version="1">MYLRGRRWRRNSATLFRVLADDLFCTLFVPYFTYSNFPGHHVSCQPCNCADIAGSIGIATSTRSCTNPSPANGGAECVGASMRAVVFCNVISRYGTQRNYRFFGDILPDGTPCGTNKYCLDGECLPLTCDKSALITRDLSCPTISERCNLETNKISTAGGAQWLSWSTWSFCSQTCGTGYRQRIRSCSDGKNQCLGASSEKKQCNLSACGADTRSDQENNWSEWTPWNQCSVSCGTGLQARYRRCTDSSQNSISFSCPGMNFSFLKSPGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5R2</accession>
    <name>A0A183I5R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15074</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041574">
        <property type="protein sequence ID" value="VDP20268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5R2"/>
    <dbReference type="STRING" id="387005.A0A183I5R2"/>
    <dbReference type="WBParaSite" id="OFLC_0001508501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001508501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001508501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001508501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8534" checksum="118A1B3C60F8F2D7" modified="2016-09-07" version="1">MPPKPSAKGAKKAAKSQKVRGSDKKRKSRRKESYSAYIYRVLKQVHPDTGMILVIPYLANNKQQRSPKWGSDKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5V6</accession>
    <name>A0A183I5V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041637">
        <property type="protein sequence ID" value="VDP20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5V6"/>
    <dbReference type="WBParaSite" id="OFLC_0001512901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001512901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001512901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001512901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6667" checksum="87808D4F480A347D" modified="2016-09-07" version="1">MLLSLNNLNTNIPESPLPPPLPPSYALWPFNLFAAILEMIDGQREKWPEMRADQYAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7K8</accession>
    <name>A0A183I7K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15720</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042711">
        <property type="protein sequence ID" value="VDP23451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001573301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001573301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001573301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP23451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001573301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12491" checksum="219175632FC12185" modified="2016-09-07" version="1">MGYHGTRTGSSSQLAILTPNQRENIIRKERERRRLIRHPTGTPRRSRRSQITREELARAIHRHREALNKLRRENEREQRRRELILERRRKAREVANVRSRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7S7</accession>
    <name>A0A183I7S7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15788</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042893">
        <property type="protein sequence ID" value="VDP23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7S7"/>
    <dbReference type="STRING" id="387005.A0A183I7S7"/>
    <dbReference type="WBParaSite" id="OFLC_0001580201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001580201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001580201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF93">
        <property type="entry name" value="GALECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001580201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12435" checksum="A5701CA8692B75E6" modified="2016-09-07" version="1">MDRMIIVFNTFNKGEWGKEERKSNPYKKGDDIDIRIRAHDSKYTIYVDQKEVKEYEHRVPLSSVTHFSIDGDVLVTYIHWGGKYYVSISCFLFFVFFFSTLKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I853</accession>
    <name>A0A183I853_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15916</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043236">
        <property type="protein sequence ID" value="VDP24873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I853"/>
    <dbReference type="STRING" id="387005.A0A183I853"/>
    <dbReference type="WBParaSite" id="OFLC_0001592801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001592801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001592801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP24873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001592801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21691" checksum="7097BB24F5F25AF2" modified="2016-09-07" version="1">MSDSVRRRMIKERVMPKAEEYWFMTDHAQLRAAAAELFLNLLFCEDFFKEVIRPGTDRLKLWVLYSAEEDERLALASSAGFAILTESEEACKRIIDEMKSWPEILRDICMSENIEIQRRGLIGIANMVQSSEKVACEIVAIYFFVLKITQPLLNYSTTVINYVDRAESHQVESSLEKYSSKISSVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UFA2</accession>
    <name>A0A3P7UFA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001516">
        <property type="protein sequence ID" value="VDO33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="69" mass="7766" checksum="E003A79AF575DEC7" modified="2026-01-28" version="1">MNTICSYTLLDVRVPTRLTSYDARQRRMHACVCSTERREKHRGGPGILTAFSNPSETVVVLTIPKFGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UGM9</accession>
    <name>A0A3P7UGM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001645">
        <property type="protein sequence ID" value="VDO34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H5H7"/>
    <dbReference type="OrthoDB" id="6144703at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="238" mass="28052" checksum="231E7DFA9C757B0F" modified="2026-01-28" version="1">MQAVPCAPIDASKFIAYVNERRKKRILFKGEYIMITHSVDTTKCRTNVGEKMEGRNQFGDILPYDYNRVVLRRLPGEINSHYANASYINSWLRERAYVVTQSVKTKPAISEFWRLVWELGTNCIVMLTKVFDFMRVMCLQYWPTTTGQYGKFKVETLETRRYAYFVIRTLRLSKLETGQAVGQQARVIKHFHFTEWELDSVPYTSAFIELRRRVRLHTNKFFTDAPIVVHCREDIIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UJ78</accession>
    <name>A0A3P7UJ78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001836">
        <property type="protein sequence ID" value="VDO34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10438097at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="65" mass="7390" checksum="3809308C1B0895C3" modified="2026-01-28" version="1">MKRQLASNRHTRSDRALSVGCQYRSHYTAISELTPSKPLFQDCSSIPLKKLRIIFGSIPILHSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UNW4</accession>
    <name>A0A3P7UNW4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002388">
        <property type="protein sequence ID" value="VDO36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UNW4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="186" mass="21296" checksum="E280352FCB04D64B" modified="2019-02-13" version="1">MSKFYVKHFCPLFSFQTGNHKGWAFVLFTDNEVAQLAAEAMDGYLMFEKRLECKVVKNKDFPACLRKGPRIISPPLKNATRKRHAKKLNKMQSGWCEEATKKRLLKNIKIKESKFAELGYRLPPIAGLSETKQVVPLISETSSMKAEEIKSDDVENQVQSKLSKKLKKTVVTKEAMADMVRSQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V3A9</accession>
    <name>A0A3P7V3A9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Animal hem peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004137">
        <property type="protein sequence ID" value="VDO41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V3A9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF131">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44230" checksum="3441E6A7839A44FA" modified="2019-02-13" version="1">MIIFNFAKIRRGDRFWYENFFVPTAFTLEQLGEIRKTTLARIICDNSDDILQIQPNVFIIADIYTNFPVRCNSTIIDTIDLTKWTDQEPRLKLPITTATLEKAILLGAKHAKYLNEIEANRINAHGDRNINRIRNSAFREHSILMAPKNISLEISRRAEILRETTKILLTGDGLSEEERLPLELDLPTLQRLLPETDVSQFIGSITNFLGDENPSVEECLPQPLPCDHTTKYRTFSGWCNNLKFPHYGNAFAPMRRLLNPIYEDGFDSPRILGVDGRKLPSARRISNVMHAEVPAFHSKYTHMLMQMGQLIDHDFAHSPVSRGPGNTILDCSRCDSPETVSIHCFPIPIESGDPYFPHLHDNGEPRCISFARSLLGQLTLGYRNQICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VQ83</accession>
    <name>A0A3P7VQ83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007447">
        <property type="protein sequence ID" value="VDO50076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10585953at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="157" mass="17523" checksum="CDB9DE1DBBF0B214" modified="2026-01-28" version="1">MENFSSAQTSQLIMSSGKVLRFLLAIYIEILISPSITEILLQPSQEFDSVVNDVPTTTIGNTINTTTIINEIQTTPDIHLLDADSDDDATILKDFLYTNKSMDSSSTLSTIILKSSESKISNRISSKGAFFCRYHTIPYKTAKIRMYSNIARVDENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XXK0</accession>
    <name>A0A3P7XXK0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS9996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012859">
        <property type="protein sequence ID" value="VDO64997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XXK0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF1">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO64997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="116" mass="13189" checksum="DC149D591F111419" modified="2019-02-13" version="1">MFFFFSHFRFLKRVPNGCAYSAGIDYSTALLLSVFLGWLGIDRIYLGYYAIGFVKMFSFGCFTLLYLLDIVLIALQLLGPADGSAYRINFYGPKAIPIRFSNDTYVSLYTCFDCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B6L5</accession>
    <name>A0A3P8B6L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015034">
        <property type="protein sequence ID" value="VDO72118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B6L5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018013527" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO72118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="130" mass="14621" checksum="BD5381053BC6BC6B" modified="2019-02-13" version="1">MHFLPTSCLSLLHFLPTSCLSPLHFLPTICLSLLHFLPTSCLSLLHFLPTSCLSPLHFLPTICLSPLHFLPTICLSLLHFLPTICLSLLHFLPTSCLSLLHFLSTHLFFTISSFPFNNFAVICIILQIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BEV0</accession>
    <name>A0A3P8BEV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040676">
        <property type="protein sequence ID" value="VDP15980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I397"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="203" mass="22916" checksum="C7C20875C7BC2A15" modified="2026-01-28" version="1">MENSVIISTPVNATATTTVSQKMGPVKLLKRSARRCLFGRPDPQNVDKWLTKELNEIRREQQLRWDFLFGPENPCASAISTEWEFTPVPAESVPQFYRSSYYLSSRCTPCETENCMPCSSSISNNCNVDSTITSVTSDCSSPEAILPATSGLLRFKERRIAKKQTKLTAFMNVDSRKRLRQQTKKVPSSPKSIRLIGHCRSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ERI0</accession>
    <name>A0A3P8ERI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040366">
        <property type="protein sequence ID" value="VDP14529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1X5"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="335" mass="37458" checksum="23B12F4FD0D66C5C" modified="2026-01-28" version="1">MQRLITIEQFGITKTDEERVVKISLTNNNGMKIELLNYGAILMSALVPDRNDILRDIVLGFQSLKEYESDIHSIGAVIGRVAGHISNGKFAVDSREYELGLNAPPHHINGGARGSLSKKLWNYELLDEGNGVCFTCISHDGEGGYPGQVHLEVTYILTNENEVVIDYRASTDKSTILNIANNAYFNLDGEGMPSLNNHIIQLYTPNYLPTDENGFSTDLMEANGNQLDYNHDFCFKMDELNMSKKLRPIASVASALNGIRMTVSTTYPCVHVNLGSWLNRLNGKANHVYDRHSAFTLQCRGLSDAVNQPHFPSIILRSDELYQHLNVYQFGLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXU7</accession>
    <name>A0A183GXU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WWE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS57</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000013">
        <property type="protein sequence ID" value="VDO24358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXU7"/>
    <dbReference type="WBParaSite" id="OFLC_0000005601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000005601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000005601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000005601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24047" checksum="24065A2CC65A7D73" modified="2016-09-07" version="1">MGTSSLISIRITQAIVEMMDGETSYHQDSQRWMNGQGNKRQLPHINDNYPRQFISLWLERGTYGWMPYQYELDALDFHMEQQRSFKNILLIFLIRLNQKGSTMLNVNSHNSAMIEYRCLSGNRQSVGIHRPITTSGKCCANGEKFVVVDGGVLMLVSFMSEAMMDSMVYWPAIWAYEEEDSYGRNMNDPFPNFFTSKDQQLLLRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY98</accession>
    <name>A0A183GY98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F member 1 family protein, ATP-binding cassette sub-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS208</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000057">
        <property type="protein sequence ID" value="VDO24996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY98"/>
    <dbReference type="STRING" id="387005.A0A183GY98"/>
    <dbReference type="WBParaSite" id="OFLC_0000020701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000020701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000020701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002050">
        <property type="entry name" value="ABC transporter, class F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000355">
        <property type="entry name" value="ribo_prot_ABC_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="91"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="418"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO24996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000020701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71567" checksum="721C264FA98058F9" modified="2016-09-07" version="1">MDGAVTIMLSDEKIEKKLSRKELKKLQRKAEYEREIKEMGGVIENQEEKEAVEKKENSGIGSGAELGQQFSVSQQAKSSGQRNQLENAIDIKVENFDIAAQGRVLFHKAELTIAFGRRYGLVGPNGMGKTTLLKHIAARRLDIPPNIDLLYCEQEIEVDSTRAIDAVVKSDKHRLALIEKEARLTKKLEEGDISIGEHLKEVTDELKSINADAAEPKARRILAGLGFTKTMQEKPVEAFSGGWRMRISLARALFLEPTLLMLDEPTNHLDLNAVIWLDNYLQTWKKTLLIVSHDQGFLDNVCTDIIDLQNQKLYYYKGNYSAFKKMKDQKMREHMKAFETQQKQLAAMKKSGKSSKQAVEEMKNRLQNKQNKVNKGKKNSNAMTDKADAASVELLEKIKEYNVKFALPDPTKLSPPVLGLHGVTFGYKDQILFKNLDFGVDMDSRIAIVGPNGVGKSTLLKLLAGKIEPQHGELRKHRQLRIGWFDQHANEVLNGEQTPVEYLFTKFRIDYQDARKRLGTVGLPSSTHTVKIKDLSGGQKSRVALAELALGAPDLLILDEPTNNLDIESIHALAEAIENFGGGVVMVTHDERLIRETNCQLWIVENLGIAEIDGDFEDYRKEILEQLGETSVPQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYB4</accession>
    <name>A0A183GYB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">K-Cl cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS224</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000063">
        <property type="protein sequence ID" value="VDO25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYB4"/>
    <dbReference type="STRING" id="387005.A0A183GYB4"/>
    <dbReference type="WBParaSite" id="OFLC_0000022301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000022301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000022301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000022">
        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013612">
        <property type="entry name" value="AA_permease_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08403">
        <property type="entry name" value="AA_permease_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease N-terminal" evidence="18">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="16">
        <location>
            <begin position="159"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="17">
        <location>
            <begin position="662"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000022301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="973" mass="106883" checksum="0EA07F1D29EC92D1" modified="2016-09-07" version="1">MRSGATEVLPEMMEEDSRPMNNITNLHNSSQTSPSSTNGTERTVRFSVENEIDGHQSGEPEDHNVAFNLKSWRNMQTIEHPPIIDFYRNSVDEGGGITSRPSMKQLIHGENAQDTVIGIDEFKKDADDIIKGERETTAKLSKFEPPAPVARTKFGWIQGVFVRCILNIFGVMLYLRISWVAGQAGILLGCAVVLLASLVTFITALSTCAICTNGDVKGGGAYFLISRSLGPEFGGSIGLIFSVANAVGAAMYVVGFAETVRDLMKEYNFALIDGGMNDVRLIGLVSCCLLMAIVFIGTSFESKMQMGLLVILTLSIIDYFVGTLAPVSESQLYRGITGYSFITMSENMLPNFQSGENFFSVFAIYFPAATGIMAGANISGDLADPQNAIPKGTLLAIAVTTVIYLMVVFTTGATCVRYADGFKLPYIINNSYFIPDCAQNNTCPYGLMNYFQVMENESLYGPLITAGIFAATLSSALASLVSAPKIFQAVCKDRLFPKVDFFARGYGKDEEPRRAYVLGFVIALVMILIGELNAIAPIISNFFLASYALVNYSCFDASFADSPGFRPAFKYYNMWVSLSGALLCISVMFIVSWSTALLTFFFFAMLFLYILYRKPDVNWGSSTQAHTYKNALQAMQKLANTEEHVKNYRPQVLLLAGNPAARPSLVDFAYNITKGSSLMICGFVVPYEPCDRVFALLRKLDVQMNEWLRKRHVKSFYVSVASPSLRTGAQTLLQVAGLGKLKPNILITGFKRNWADRGVEGLSEINDYFGVIQDAFESRMGVAVLRNSRSGLDYSELMKRHNVGDTARLNLPEITRSSSSTKADSATINPVMQETKSTESSGTTIDKRCIIDWFLTDYNVLLLFKTSDSYAQSLSAMRLHRQRAIDVGSGGKSDTAVTTANLDTFATANTTDALNVEHFDSINESLLLGNILHLAATGSYLANCPLECFDEERNETEMDVCAAENHSDDCEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYK7</accession>
    <name>A0A183GYK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Surp module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS317</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000094">
        <property type="protein sequence ID" value="VDO25364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYK7"/>
    <dbReference type="STRING" id="387005.A0A183GYK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000031601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000031601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000031601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="364"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="497"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO25364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000031601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="707" mass="81690" checksum="35CAFE7E2803989C" modified="2016-09-07" version="1">MDRYRRRRKEEEEAELSKAYEQFREAFEDGTSIASKSFVRAAIVNANKVIEDISSKPSIYNPKIELAKKASAAPNSFEQAKKIAEEKAKRMMEEARKANLTTTRPPRPGKTQPKSRTSNLEAFKEELKRNMSHVDIPPVSLIVRILFNSMQEEREQRRHLRSQMEQMGMEKEALDRIAPLIDNPYLHGTGEYDNDPNTTNIYLSNLSLEIKIEDLYNTFGTFGPLASAKILYPREEDRKREHLCGFIAFMTRKDTDRAIQGMQGKYIRGSEVRMSLAKPVSIPPQPIYVPPALLEFAMPDPPTGLPFNAKPRKCDLDALLKKCPLPRLGSSLPESDHGLEEYQKMLRNAVVRVVVPTERSLLILIHRTIEFLVREGPLFEAMLMGRERHNPVYRFLFDNHHPAHVYYRWKLYSILQGETPQTWRLQKFRMFDEGSWWQPPPHNILTGGMPECLYHTAFDGGLPVERPVAKSRKRKYSSSEDEEEDRKEIKTKWRGVLSTAERDELEDILRGLLPEKSSVADAMVWCVEHATCAKEISQCLHESLTIDETPLHKKIARLYLLSDILANCAARVRDVFYYRQYIGDLMPEIFRELNKTYEKISARLKAEQFKQRVMLCFRTWEDNSIYPTDFLIQLQNVFLGLAKEDEISEDDIDGAPIEEGPDEAVTKKESIFEEEDIDGVPIEEDTLETQPKKAATFKRSQWDVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYN5</accession>
    <name>A0A183GYN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDNF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS345</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000107">
        <property type="protein sequence ID" value="VDO25479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000034401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000034401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000034401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000034401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17290" checksum="4ECFB51362FB0864" modified="2016-09-07" version="1">MHSSDQMTNGFVTNTCQPQCRNAVLNLYQNRLGRSLLRTDISCIPGRYELELCNLIPNKLPVYCNLAKLACEADLMCSSRYGIFTSECENEVARGDCSSRCRELLNDTLKTQQGTAFIDCTCTDKDDKLCQHLKDVILKSCMTVINFILKFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ65</accession>
    <name>A0A183GZ65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS525</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000182">
        <property type="protein sequence ID" value="VDO26097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ65"/>
    <dbReference type="STRING" id="387005.A0A183GZ65"/>
    <dbReference type="WBParaSite" id="OFLC_0000052401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000052401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000052401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO26097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000052401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139977" checksum="93D39D02D78842FD" modified="2016-09-07" version="1">MDENATNCGSDVGRDIADMENFISRIVWGQRSWLEDSNKNDIQYLKKRNIWLRDDVTFSDRVIRTVVSLSNAGLCPANMDVVDQINTLFPTEQSLSQLDSVMHSVEDEIVDLDCELAKLVEMHGKAGAEGDQALHEAHAAMGDLEEHVRAVCLKTQSSENVVQEMTRDIKQLDVAKRNLISSLKALHHLQILLTGVYSLGSWIDQHRYGDIASQLPAILNVLQLFGPYMEVEHIKNVAEQLERLKQRLAIQLVADLKHSFQTGVLNSSVTDMCRVASSLDPAIREDFCKWFIEHQLSEYTVLYGESESIAWIDKIDLRYRWFVQKLTEFEKTGVMKVFPADWNMGRRLTLGYCNLTREMLERMMSRRWLELDYKVLAHAINHTIMFENLLCKRFPAKEIYNFEKIIWRAFDKYMDVFVAAQKKNLDSFLEECVIKIRSGAERPTRETASHAYPLPSSADMFLLLKKIIAESTKLSSNPNALLRNLVEVLRNCLRGYAHGCLTAFLPSLSSTQFSSTSILQTLMRDETAVRLTVDQQFFTCCILATADWCAETTLQLQEKLKQRVQSIDLNQEMELFYGISNSALSVLVQDVESTCDAALQTMVKKNWNGVESVGDESLYVSLIRSHLRSNVPLIRDFFVDRRKYFAHFCLKLATQLVNKFLGALFRCRPVGVAGAEQLLLDAHALKTFLLSMPTVESSINTKPPMMYTNVVIRTMTKVEMILKIVMSEIDSPEDFVMAYVRLLPDSDSSELQKVLEMKALRRQEQTSIIQLYKSRIEIQATAADSCCRHPVIISDLSIRKYRRFEHEKIGTAREKESLIYECEVMNCARRKVILVLMINSNCEEKEIGMSESCSKKLSFELPLFFAYVTGNDACDVLLELERKYGIKFIISEDSVYVEGLVEPNQKAIKEALSTAWKMDNFQRAIEIYELTNNSNYQFLFEVSPSEAALVQLNVKTLLHRTGVLQLKTDSNGHVCIFGNGGSICDAYDTIVSIFRKASFKSSTAMQGFSGEPCILLMNIPSAIAQFVFSNDKRSVNALERSGRCVVEPHFNDVDAVGNIKVDIITKDLANALAIKTALMELIESHVGKIHKWPTPITICCGSRVSRSVPELSCRTLDECEAVLYGPTDKSLTFSVPASEASRLIGTRGANKKRIEGHTNCCISLHTEAKYGGEFPVEIIGQNVKQCEAAQRYIQNFLKETPGINKNLSGSNSSSAMQSPQLFHSQLELSHLDALSPICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZC6</accession>
    <name>A0A183GZC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS586</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan nuclear receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000204">
        <property type="protein sequence ID" value="VDO26318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZC6"/>
    <dbReference type="STRING" id="387005.A0A183GZC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000058501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000058501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000058501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF1">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="164"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO26318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000058501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63269" checksum="C3C92077C189DFFB" modified="2016-09-07" version="1">MFGASTASVAHSSYDIKDKSIDNNAVCAVCGDGHAKLHYGILACYGCKGFFRRTLTGKYRYVCRFGNNCIVDKCELFFLSHPFELCLVNQRNSCRYCRFQRCLEVGMDPKAVRPDRDLTGRQRVPRLRKRQIDEELFNHMNSADSNFYQMRLQGDDWSRKLPMESRVLLMQLMNIESKIIKRDETSSTRNNDKNLSKTVSLREFFELRPVLASRSSEIRYESYRIAQLDELSHIAHRRAMAVVDWVDLLAELADITDTEDKVALLKSCYSPLTIFNFSTRTAQNTDNPNLLYLCSFSYMPRKLPLECTQTNQLSNDLIDRILNELVAPLRKLKLEEEEVVLLKAIIVLNPSLSVIAQQVVSDFRDRIQEALFQVIKELNSIYTATARFGNLLLLLPTIMTLSGTMSENLQFVQALARDQKEDNLFNEMFGEMYAKLDDSMTSTSLKLPILENPAEISLKYASSSHRSTTINGSTVNHEKFRVDSSTQTYSDDSLKGSSLSSASLCKSLTPPSHISFSPLHYLLNDDDLTDYSIALDCNDIHNDDGDLFFLMDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZZ1</accession>
    <name>A0A183GZZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS801</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000314">
        <property type="protein sequence ID" value="VDO27127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZZ1"/>
    <dbReference type="STRING" id="387005.A0A183GZZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000080001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000080001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000080001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12940">
        <property type="entry name" value="LEM_LAP2_LEMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000001">
        <property type="entry name" value="LEM domain containing 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051656">
        <property type="entry name" value="LEM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019:SF9">
        <property type="entry name" value="THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO27127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000080001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38866" checksum="00433ED60561FEBB" modified="2016-09-07" version="1">MGLGDEMVDIDKLTNEEIRDQLMVRGCDPGPVVGSTRSVYANKLRRLLEGKSESVVQPESAVSRAAKADGLKSSAKRGDVSPQKSRSPRRATRSSTQEIIGPSKVQNTPITSKISRVSPKAADISPVISRVISDSKQPSPKPPMVQPSIPGSPKPHVDFGFEARTGANTIPEFHRSPLRASVTSESTPLNVTSDSVKIPKSFGITSDVYRATPTTRFTSLRDNWGNQKVSDGSDDDLRGEESSRILSPSWKKDHAYSVRYDSEQRSITQRPDENSTAHYNPTPHYNSGAVFENSYNRYGSRRSDLVDKEKTLPNYGKIGFILLFVIITAIFIFFVVQNYAELEIGEGNKEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0J2</accession>
    <name>A0A183H0J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1002</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000418">
        <property type="protein sequence ID" value="VDO27851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0J2"/>
    <dbReference type="WBParaSite" id="OFLC_0000100101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000100101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000100101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000100101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21649" checksum="12BB85644EB76B87" modified="2016-09-07" version="1">MCITFFNVKPLINRTEQLTTKGEDTLCLAPKTFDSRPRSTRNKLVDLPPPPLFDRKLLEIYGIPIKSDETNGEIPLKPIRIAPPPPPPLPPSQQPCIATSTDGQLLNPLEIPTISSPPRRSLYETTTELVRNGPHSNSSSYRTKIRPLISTPNPPDHECIRNPQSSQSLVDLITPSVHYQRSNSTGKALPIETSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Q8</accession>
    <name>A0A183H0Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1068</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000458">
        <property type="protein sequence ID" value="VDO28112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0000106701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000106701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000106701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000106701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8152" checksum="CC8B580B9E19FC17" modified="2016-09-07" version="1">MKPNKTSLHLTSERVSSQTISDLGLGGSVHVLGETGRFGDMWQNKFIDDGSGSDELCRSTNSRLPSYHFLTYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H130</accession>
    <name>A0A183H130_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1190</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01000525">
        <property type="protein sequence ID" value="VDO28591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H130"/>
    <dbReference type="STRING" id="387005.A0A183H130"/>
    <dbReference type="WBParaSite" id="OFLC_0000118901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000118901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000118901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO28591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000118901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35726" checksum="D4CACFE66F09AC16" modified="2016-09-07" version="1">MNLGYTVFYESAVTCISGIHVDLINSDKQCYHIAEEFAGMFYPPTIADDEVVDVMESTDDEIDEGLEVKKKRQKGMSKDFADGFVFNCLSGEDKEVDILESLQPYVKKSNISTLEEKIERERTKFFNSGSFERIPELVQEMEDISGTSRSLILRKVTSSAVFNILLKRMDNVREKQPRKKKCRETQNFFDDATSSNAMNAEMVIRFDQMNLSKSLLKAITACGFAEPTRIQSTCIPLALAGRDLCACSATGTGKTVAFMLPVLERLLYRPQQKAMTRVIVLAPTRELAIQIFQVSRQLSQFMRIDICLCAGSSFSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H148</accession>
    <name>A0A183H148_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1208</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000534">
        <property type="protein sequence ID" value="VDO28667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H148"/>
    <dbReference type="STRING" id="387005.A0A183H148"/>
    <dbReference type="WBParaSite" id="OFLC_0000120701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000120701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000120701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11781">
        <property type="entry name" value="SH3_Sorbs_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="399"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO28667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000120701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55917" checksum="92E6B853FF426A88" modified="2016-09-07" version="1">RKAKFPKQLFTGSWTPNPQRDNQINSLRNYELQSRRSKSVGRYVESQNESERLHQSPSECVNRGPNEWKSEWRHKLGAAPCCPSSSSSLHYATNCFAQQRSKTQHFHLPSYRFQQSCKRGVENPTTVPLMLTRSPSKCLCCGLLSHSLSWSEIDYLSKALDKKGIHMESFTEQLNNLIKSIAIGERLDQSVIYLQSLVDCLEACGTNKSNNRKCKSRSTSPTSFPTPDHYLICKHLTNLTTTLCSSCSPCISSGRLKMNSQSSGDVTELKKLSKYDVLVRQKVEKLSEELQQQRNRRHGYIPSASPALQKNFDRFSGLINEFGRLERATTPQTISQSGITICTALFSFNAVSPKELSFNRGDVIRVYRIIDNNWMEGEHNGQIGIFPSSYVQIDNDEESELIALYSFSARNKNELSLKKGEILRHLRNIDTNWIEGKNIHGQTGIFPKSYVQEAYKVNPHENIETAVPDRPKTPYTSTASFRFIIILYFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H188</accession>
    <name>A0A183H188_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Olfactomedin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1248</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000559">
        <property type="protein sequence ID" value="VDO28841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H188"/>
    <dbReference type="STRING" id="387005.A0A183H188"/>
    <dbReference type="WBParaSite" id="OFLC_0000124701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000124701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000124701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF83">
        <property type="entry name" value="OLFACTOMEDIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="5">
        <location>
            <begin position="269"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000124701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62485" checksum="F0C3A8059361DF6E" modified="2016-09-07" version="1">MLKCDKNRIVHTRTRRQSVEIKRSVAEQPRLSKPSSSSSSSSFAIHNERTAHIEQDTIIPKIFFETSCKRIHRYCAETGRKFMGFQGPRGPPGPKGVIGPPGKKGRQGKIGRTGLIGSTGGEGQQGISGRCNCLTPDFYLQQATVSGPPITQVEENTVPVPVLVIKEIEATFERQFFVTKLVPLKPITIPSGPIIDRLPPMGKTDLSKLTTVVKTTPRILKKPTVVSESTSSSLTLPGDYIATRRDFIADSTTIKPYDGLPTFGYNRRVCLLDAIGIPVLHAESQYSSVGSWMRDGLPYNEEMAKRRWVTDDYASPVLYEYENERQLMNKKQKIKYYIDYLASGTGNIVYNGSYYYHRHSSSMLVKYDLESTNQIQMDLGDISYRDCSRRQDHTFENCNEMERDVWLYDRPHNYVDYSADENGLWAIYVRFGMQHITVSKIEPDLHVVQTWDIYELNATGIAETFIMCGILYGLKSGTDRDTMIDFAYDLFSNKTIDVNVKWYNPYGGMTMLHYNPIDGRLYFFDSKRLLSVNVRVEGQIDQFEFSDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2R7</accession>
    <name>A0A183H2R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1777</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000902">
        <property type="protein sequence ID" value="VDO30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2R7"/>
    <dbReference type="STRING" id="387005.A0A183H2R7"/>
    <dbReference type="WBParaSite" id="OFLC_0000177601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000177601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000177601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000177601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31964" checksum="FB9EFCCB3064353D" modified="2016-09-07" version="1">MDFNITVHYTAIDDLNDDLYWNQLNGVEIPPSRSSRFAYFSLRYNMDDHYLIAGGSDGFIYMFAHVEPRLQMFQAHQDDVNAICCSKTNPYVFCSGSDDGLCKVWDTRLVGNTTFPVGIFAGHRDGITYIDAHGNDRYILTNSKDQTIKIWDLRRFSSRDAEKVTLNAVRRQRWDYRYQHIPQIFHSVGPLEGDGSLMTFRGHSVQHTLIRAKFSPERTGFRYVYTGSTEGNVYIYDILTGEIVRALDGHRSVVRDCCWHPDENEIITVSVSSVISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3T9</accession>
    <name>A0A183H3T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec3_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2149</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001178">
        <property type="protein sequence ID" value="VDO32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3T9"/>
    <dbReference type="STRING" id="387005.A0A183H3T9"/>
    <dbReference type="WBParaSite" id="OFLC_0000214801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000214801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000214801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000214801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32463" checksum="44050F729007A900" modified="2016-09-07" version="1">MVFGRLVVLVKRQMDTYLDNKSYQLAEVKISKRVRIGILESVYQFAELARTAEAAFAGTERRADLNRWYAQLITSLKDGIEYAATSPFSKSPAAVVRFENYHYFYSVLSELKIDCLDVQRKEAKKAYQDNIEIYVKELMGRPLEKIHVSFARAIYYYEIRHFFESVENAIRQGVKPEEIAFHQQFSRLELKKVISLYPEKEVKKGLEQLYKKIEKHLMDDSSLLQVVWRNMQDEFLKQLKHYNEVMGQCYPNSRIDFEVSVQDVLSYFSQFAMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H404</accession>
    <name>A0A183H404_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2214</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001227">
        <property type="protein sequence ID" value="VDO32257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H404"/>
    <dbReference type="WBParaSite" id="OFLC_0000221301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000221301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000221301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000221301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5591" checksum="8FD912647EAEF65B" modified="2016-09-07" version="1">MRCRQRYQQQSSGVMEGEQHEQRLISTTSVVTTSYVEDNSSPYLEFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H429</accession>
    <name>A0A183H429_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2239</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001245">
        <property type="protein sequence ID" value="VDO32331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H429"/>
    <dbReference type="STRING" id="387005.A0A183H429"/>
    <dbReference type="WBParaSite" id="OFLC_0000223801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000223801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000223801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000223801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32632" checksum="490307E076B701EE" modified="2016-09-07" version="1">MSGRPDRSRLSLPLKNINARYDTEAANIASRPAQQKLVKSLSNPADYFVPTPVDIRFPPSSSNSLKESRSCPPLSRAQRFLLRCSNKYLLYFSLNNGFSIRDTISNGTAKFFGVPSSDNCQSSTGTPIDPKWSCRRLRFICKHYGKTKDIMMRELKQQNVPSVLDDLIDIPSPSKSITPQNEIRETVFMASTVGTAETFSRSKSVESRGSRLTQQHLERRDSVIKIAYDKISAMVQRRTLRPKKTYATVKRGRSVSGSFAPFSNQQTGNIAHIGIGPPAVDTFAGKNNASTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4I8</accession>
    <name>A0A183H4I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2397</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001372">
        <property type="protein sequence ID" value="VDO32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4I8"/>
    <dbReference type="WBParaSite" id="OFLC_0000239701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000239701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000239701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000239701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57723" checksum="CB2A382A3D6DEA2B" modified="2016-09-07" version="1">MNCRELWCLASVDGAECKETFDTYDDFEEHFCQKHLDLALFACDAKGCTAQFGTVLQIFRHLAVCKRQDKKIKLLQYSDDALESLAILDRAKLLAVQCCVKRPKRALELTEMNDDVTTDQNGEFNVQCSLDGMGFRCSSDDDQLHVPIMEPFGIRQVKNVESGSYASRSERTITAARQVAWKLKKQMLLEERMKKNKPLEKPSRDAQKKQKKLPVKITDKTRISALINDDPKKVKGALSHLQTVKSDLSPDSVLANTNETNRLGENIVRKQSHKIVNIIDVSGTMNSDMPFESTKHIVSAESKPKSLLYKTQDPVFQKQPKIFESSLPASPNHPPKIYDTSHPQLSFGAIDTRPPDYSEFVRNPVINPMLREIPLSRFPIPPLQNSPARSSNDCQNTSEINCPPTSTILASQQAMFASSQVDVQQNRGNIEPHGILRTARIKDIFQRTVEETGQMDFDVLSLFSKRVQEYKTLGHLKASTTQAKELERPAGICYVSIDSKVMLCFFFCLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5E8</accession>
    <name>A0A183H5E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2708</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001617">
        <property type="protein sequence ID" value="VDO33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5E8"/>
    <dbReference type="STRING" id="387005.A0A183H5E8"/>
    <dbReference type="WBParaSite" id="OFLC_0000270701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000270701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000270701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000270701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15815" checksum="75FD3418244AF482" modified="2016-09-07" version="1">MQRDRLLFDDVTSQMDKLEDFTGRVKKMLPSETQDRIAMFIFFIVLPLGFLFEIFVVLPNEHEVMSKGWNVRVGILMFLGLNAFANVYKIISVGPNGNYSDLPAIQKPGYRFCYNCQLNEPPRSHHCPGNCEINHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Y1</accession>
    <name>A0A183H7Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein Lines homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3593</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002458">
        <property type="protein sequence ID" value="VDO37072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Y1"/>
    <dbReference type="STRING" id="387005.A0A183H7Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0000359201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000359201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000359201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="1">
        <location>
            <begin position="363"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000359201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54887" checksum="B1E4641A2BC5518C" modified="2016-09-07" version="1">MTFFALIVIIAEFSEKVKQHLMHVVSESFISRLRERLYSLSITIPTETIVSGDVEGCLKQLLGVLLSMNSGCNDFLLGGKLSEHLTFALSSTLRLNAKRLRLSREVTEKNDVLGNLYYFMFQILLDCISANVGQTKQLEELTGSYHFAIYLLRAACTQTTKPTQKFIDTLQVLVEQAVKLLERIDIHHSPRDDIIEDDNDEQGTESCLVTVLLSFCAVAFTCTPSIFLCQKLMNETLFEIFKWTKSSYLICAESAEHVLKAAALAVGEADISSLCVTYGKYLLPKVAVRSRAYSSNLRTPCVLSSLLDHCENAELFEITNHVVQELLLAVDLGSQEWLILILKALLSFGMAIGKWFPDIRPQEIECSEDNPDKIAPKHCFVESVNSILKRTKHLLFSSHIPVRLLVLQVLNVCLKDLQFFPDDHLPMIHQNWLAVLDCLQEKNLNVRLAGFKVIALKIPVYCTGLFAMMKMIYMNVSTLKDMIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Z3</accession>
    <name>A0A183H7Z3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="6">2.7.7.102</ecNumber>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3604</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="6"/>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01002469">
        <property type="protein sequence ID" value="VDO37120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Z3"/>
    <dbReference type="STRING" id="387005.A0A183H7Z3"/>
    <dbReference type="WBParaSite" id="OFLC_0000360401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000360401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000360401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056443">
        <property type="entry name" value="AEP_C962R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23162">
        <property type="entry name" value="AEP_C962R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C962R-like N-terminal AEP" evidence="8">
        <location>
            <begin position="95"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO37120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000360401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="52020" checksum="D4EFE86ADD0D2381" modified="2016-09-07" version="1">MNNLLRLDSVEDSETWFYGARDRNEQTKNTSQIISNKVQKQKPKRSLFEDSLGCFVIYKRQNDALLKCEQEGPLARVFAFEHSIYHPGQRQYLVSTVQRFWQWYKKQCDVSFYELIPQNRPARLYFDLEFYWKTNPDVKEKDLIKDFNDCVTEVFTEMFGIDLDPEKQMLVLDASTTTKFSEHIIVHLFDNHLFPSNTSMKFFIQQLKKKMLSSGRCLVWNADATKLTTLFDATVYSVNRNFRLYLSSKLGKNNPLVLAKRCNFYVQKKCLPKQQIFLDSLIVPAKYSTSEFLHIPVAESREYLNIQKPKTLTVPTQVPASSESLDYMIGYGATSPFPVLEQHIININRRWKDNASIRQWKLSMNKFTMARHIIYYISSCRYCFNVGREHRSNGVYWIADLDKLHCFQKCFDVDCNGISSNYFPLPNFVCTSLLSTKGESFCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8K4</accession>
    <name>A0A183H8K4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Staphylococcal nuclease domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3816</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002681">
        <property type="protein sequence ID" value="VDO37845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8K4"/>
    <dbReference type="STRING" id="387005.A0A183H8K4"/>
    <dbReference type="WBParaSite" id="OFLC_0000381501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000381501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000381501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20433">
        <property type="entry name" value="Tudor_TDRD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000003">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047386">
        <property type="entry name" value="Tudor_TDRD11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="3">
        <location>
            <begin position="173"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="387"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO37845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000381501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63416" checksum="698A732DFB25859B" modified="2016-09-07" version="1">MGDALIVQKENGDEIKIWLSSVRPPREENRDTENKVGRQFRPLYDIPYLFEAREFLRKRLVGKKVQITVDYIQAKTEQFPEKTCCTVMSGGLNVAEALVSKGLAKVIRYRSDDDNRSSQYDALLAAEAKAEKSKKGLFADKELGDKGPVLRIQELQGDAQRSKQFLPYLQRSGRSEGIVEFIASGSRVRLYVPKETCLITFLFSGIDCPRGARIGPGGKLIGENEPYAEEAAKFTRSKIMQREVEVEVEGMDKSGSFIGYMFVQTEQGLCNMSVALVENGLASVHFTAERGSYYSQLCVAEEKAKKAKLGIWAKWIDEEAIVQAEIASAAEKTERTINYRKVVVTDVQRGNFKFAAQLVDDGPKLEKMMKELREELRIKPPVVGAYVPRRGDLCVARFSADKLWYRARVEAVKGKKVDILYIDFGNRETVDVTSMAALPAGYAAQPSGAHEYQMAFLQMPNDPDYANNSDIAFEQFLFSAPFMFINIEYRNAGVEHVTAIIETSDGTRTDVAKTLIAEGHALVEQKREKKFASLIAEYQETEKIARREHRNIWEYGDFTGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9N2</accession>
    <name>A0A183H9N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4194</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003090">
        <property type="protein sequence ID" value="VDO39227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9N2"/>
    <dbReference type="STRING" id="387005.A0A183H9N2"/>
    <dbReference type="WBParaSite" id="OFLC_0000419301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000419301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000419301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000419301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14657" checksum="13CA9EDC8284CD29" modified="2016-09-07" version="1">IFIQIKNNDPVPIVYRIRTKERSFPRFSTCHGYLEPNEEDEVCILIPNSDHWPRNPTEYAGYRHKVMIENLTFPKDALKPNNKDEASAISMVIFKATPPLTRMYTKLNILLPKVIEDKIPETSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Q0</accession>
    <name>A0A183H9Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4214</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003108">
        <property type="protein sequence ID" value="VDO39289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0000421101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000421101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000421101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053367">
        <property type="entry name" value="G-alpha_activating_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38627:SF2">
        <property type="entry name" value="DOUBLE-STRAND TELOMERIC DNA-BINDING PROTEINS 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38627">
        <property type="entry name" value="GA BINDING AND ACTIVATING AND SPK (SPK) DOMAIN CONTAINING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000421101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11220" checksum="3B4D9C802D1A03B2" modified="2016-09-07" version="1">MAVRNTYTERDERLMWEHVFERLQIGDEAAYKPKGLKLWEDFEATGRTNKTASSLATHFRKAMYDHIEEAKLSMEQQLYIANQLSLPLSKRQQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAA3</accession>
    <name>A0A183HAA3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS4416</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003343">
        <property type="protein sequence ID" value="VDO39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAA3"/>
    <dbReference type="STRING" id="387005.A0A183HAA3"/>
    <dbReference type="WBParaSite" id="OFLC_0000441401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000441401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000441401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000441401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21556" checksum="250C19935C114E35" modified="2016-09-07" version="1">MQRVGSGKQGSILDKSLSRGKSEVNFSTFALLFAEMIRYANNRSNTVSDLQDKLLGYGKFVGSRLLDVIVLREKGYRRETKLLNMLMFVKGTIWKNLFNKEADKLERSNDDPCQYLLIEKEPIVNTYISVPKDKGNLNCASFIAGIIEAVLEASNFPCKVSAHWHDGTTYIIQFEKLVIARENALLELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAD4</accession>
    <name>A0A183HAD4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4446</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01003381">
        <property type="protein sequence ID" value="VDO40035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAD4"/>
    <dbReference type="STRING" id="387005.A0A183HAD4"/>
    <dbReference type="WBParaSite" id="OFLC_0000444501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000444501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000444501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000444501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17305" checksum="D696CCF431D05458" modified="2016-09-07" version="1">MIFDVDREAGIRQIYHRYCIERAAAHLAHIFTTVRIRINLPIFVLLFLDCSEITGLEATHLIKRKPDILTPNGLNVIKFAALHEFQNLHAVAKEKIHDFIRGHFYGHYDFNLDKTIYLFTAGRYEFTNKGGDFFIEALARLNYLLKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB06</accession>
    <name>A0A183HB06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4668</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003660">
        <property type="protein sequence ID" value="VDO40679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB06"/>
    <dbReference type="STRING" id="387005.A0A183HB06"/>
    <dbReference type="WBParaSite" id="OFLC_0000466701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000466701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000466701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR E75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO40679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000466701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40722" checksum="01A490A13B70C734" modified="2016-09-07" version="1">MRFEQKVSMFCFMQKKVDEISAIRPDRDKTGRQKNPRRGSSENGTTKMSANSISGELPCVTSEKDSVANDDTRTCSRSFCMNSTSGHPKCPVPVGDESVLATLCEIEHICNQLRDAHPVITKTSITLIDAVLRPSLIVSRSPLIFDGSLGLAGCKEYFENLRRLIVLLFDYANTLKPIADLTPSEKISIIHNCVSQFALLVVAYYTVRNTEMVSSTILLPSGHYFHREKPVIIIEQCEDKQIILLESRIEIVKKNILDVVLSPMRRLGFTEIEMVALKAIIALDPSAANLTPHSASLLAVARGSVQNALYAHLSSRLSPAEATSRFGNLLLLIAGLSKMGAALCGMMQLCRDLSMNIDPVVDGLFFNDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB83</accession>
    <name>A0A183HB83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4744</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003761">
        <property type="protein sequence ID" value="VDO40926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB83"/>
    <dbReference type="WBParaSite" id="OFLC_0000474401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000474401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000474401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000474401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8281" checksum="692A3C916BF8396E" modified="2016-09-07" version="1">MFKDQRVSQPLIVMHCLLSSSDFPVLSLEMCIIEKIWQGYLRIRMISSIHCVKCTEKANIAFEGVIPVALVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBL9</accession>
    <name>A0A183HBL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4882</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003931">
        <property type="protein sequence ID" value="VDO41334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBL9"/>
    <dbReference type="STRING" id="387005.A0A183HBL9"/>
    <dbReference type="WBParaSite" id="OFLC_0000488001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000488001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000488001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000355">
        <property type="entry name" value="Uncharacterized calcium-binding protein B0563.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO41334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000488001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26326" checksum="09904A56504DA972" modified="2016-09-07" version="1">MFQKRLTTFLSSYIFEKCKIKGIFLIFKLFHRFFFIFKLQHKFHHDFNQRLNSGTNAPLLKAKLAGYSQEELEEYYQVFNVFDTDGSGAIGIDELESAMRNLGLEPQKNELEQIIEEVDQMGNHEIDFHEFCDVMKRMSDKQNSWNDVTRECFVVFDRSEVGVISKKDFQYILNELGDIRDKAVVDDIFAEADVDGDGVLDYDEFTFMVRNYMNDEDLATCKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC39</accession>
    <name>A0A183HC39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5051</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004146">
        <property type="protein sequence ID" value="VDO41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC39"/>
    <dbReference type="WBParaSite" id="OFLC_0000505001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000505001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000505001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000505001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17571" checksum="32B09DA4C326C9AB" modified="2016-09-07" version="1">MPHISLMSTKSLSSNEKNPEPSAICNTERVSFKYVWSTKVLMRQLNDNESVILHVSPKFATVHERIAFQWSLQMRGTTFLNHKLNEQVEEAEVSEDETECEPNYIALSLYFNDGPAPVIDDLQAVTKLLNDKKISNESNDDYVVAESKISFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC93</accession>
    <name>A0A183HC93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5105</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004219">
        <property type="protein sequence ID" value="VDO42082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC93"/>
    <dbReference type="WBParaSite" id="OFLC_0000510401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000510401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000510401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000510401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11614" checksum="2F257FF7AD0C5B98" modified="2016-09-07" version="1">MLNKILFAGLAGGKSFWLGLKRGKRNWYWDSSTYGFRAYFFFWRAGQPDITSNKNCAYSSYGGEWMSADCDNFRSPKMFICQSQLRNYGYAYYPYYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCV8</accession>
    <name>A0A183HCV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5319</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004510">
        <property type="protein sequence ID" value="VDO42742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCV8"/>
    <dbReference type="STRING" id="387005.A0A183HCV8"/>
    <dbReference type="WBParaSite" id="OFLC_0000531901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000531901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000531901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="71"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO42742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000531901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35105" checksum="B09FDD9518A6C5F2" modified="2016-09-07" version="1">MIDPGTRLNSGTSQIYTEERPYLRSKTVEVRYFITVSESICFIDSVDFVNAAKPNGLSTLSGVFAPVAISMFSVLLFLRMGFVVGQLGFLQTVAQLFLAYAIVMLTVLSLCAISSNDMISRSLGPEFGGAIGLLFYTANVFSCALYISGFTEALLGSIGEENSPSSASWKFLFCVLVSFIQLLLCLLGAKLFAKTAFITFSVISICYVTFLLSVFIIAPFDVPSNISDPSSEKIPDFNQTLKASYTGLRDIRLDVKIIEIVEHLLENKIWDEIKFRFATLSKNMLTNYTFDYTTSKPTDFAVMFAIIFSGITVCLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDP8</accession>
    <name>A0A183HDP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5611</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004914">
        <property type="protein sequence ID" value="VDO43725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDP8"/>
    <dbReference type="STRING" id="387005.A0A183HDP8"/>
    <dbReference type="WBParaSite" id="OFLC_0000560901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000560901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000560901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000560901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34184" checksum="FC1C6FD4FB0D5EE0" modified="2016-09-07" version="1">MSSKKCTAAATQASSTAFEFGDQMVLYRALLLQFQTAHNFAYSNIAPYTALLQQQFLQAASGTASSISPSALLANYWACHLNNNNCSVEGTVSTDASSKNNIENSISNGTLLKNSRVKSEKTDHDDVTHHDDLERSRSSADSAEQPELQSGSDLPNSCIVGNAATWKPLRSRSFLTDAQVAVLHAHFKRNPFPSKYELSAVAEQIGVNKRVVQVWFQNTRAKERRSNRLSVACERYSRSMWNNAISFQSAATAVAANDPLSLMAAWTQQCTGLVNNGLSVKNCQFMSYNNLELSGLFLSFQFSSFSLCFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDS9</accession>
    <name>A0A183HDS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5641</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004957">
        <property type="protein sequence ID" value="VDO43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDS9"/>
    <dbReference type="STRING" id="387005.A0A183HDS9"/>
    <dbReference type="WBParaSite" id="OFLC_0000564001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000564001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000564001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF163">
        <property type="entry name" value="HISTAMINE H2 RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000564001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30601" checksum="93659376FA6C3CF1" modified="2016-09-07" version="1">MDIWMCTTSTYIIAAISIDRFIAITKPLHYPLLVTRRRTYMSIIVIFMGSFLLSSPSFLFTNIYTSINNQCICIPVHAHKLCAIVSASLSFYVPMVLVTVLSTKIVIITRRSVTITKLLDTAKSLNPDYESQKKLDHISFKVFRGNVQIKMEELRNANKKDGSSRAKENISQNSYTDSNIHSEQRESSQIQFLKYEMNEPSDVKLEVTEKNLQSILYGFALNVSPQVWSLSSCMGHVTSALNPIIYFSLNHGIRNCFKRLFTCSINSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEU2</accession>
    <name>A0A183HEU2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6006</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01005472">
        <property type="protein sequence ID" value="VDO45097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEU2"/>
    <dbReference type="STRING" id="387005.A0A183HEU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000600301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000600301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000600301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048260">
        <property type="term" value="P:positive regulation of receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="4"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO45097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000600301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39462" checksum="21693B1C4477E0F3" modified="2016-09-07" version="1">MQLSPTVLRAKLWIEFENETGLDYGGVAREWFYLLSHDIFSPYYGLFEYSATDNYTLQINPHSETCNPEHLSYFHFIGRVIGIAIYHGKLLDAFFIRPFYKMMLGKPITLNDMESVDNEYFNSLIYIKDNNPEDLDLHFAVDEDVFGQMKSVELRDGGAEEKVTDTNKDEYIDLIIKWRFVSRVEEQMKALMKGVHELIPPNLLSIFDPNELELLVCGLQKIDVKDWKDNTLYKGGYSPSHPVIQNFWKCLLAFNNEMRARLLQFVTGTSRVPMNGFRELYGSNGPQKFTIERWGNIDMLPRAHTCFNRIDLPPYTNFHQMKERLTTAIENSEIFSGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF16</accession>
    <name>A0A183HF16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Replication factor A protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6079</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005577">
        <property type="protein sequence ID" value="VDO45318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF16"/>
    <dbReference type="STRING" id="387005.A0A183HF16"/>
    <dbReference type="WBParaSite" id="OFLC_0000607701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000607701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000607701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="82"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="7">
        <location>
            <begin position="202"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO45318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000607701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37343" checksum="AE224493335F1D4E" modified="2016-09-07" version="1">MDYEILGRDLPILGNPVHHSGNPNDYRGLNPNANILNMRTELRSPQKDGSARHGGSSSHRLANLVGQNLTPIKLITPYVNKWRICGVVTAKEDLRNIRTARRDMKVFNFELTDEEGGCIRIAAFDDVAEKFYSIIQKGLMFYVSGGTIKQANKRFNTTGHDYEITVRNDSEIMPCLDREKIEQPKLSLSIVRLCNVANHIGEPIDVIAIVEKVNDIIQVTARSTGAQLEKRDIILIDTSETEITLTFWGEQARTYDKEIEGQTIGIKGAFVKDFNGSLSLSTGSSSRIELNMECAETANLYRWYREIRPSIQARSLSMPTLTSDSYGNSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFY4</accession>
    <name>A0A183HFY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6395</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006049">
        <property type="protein sequence ID" value="VDO46425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFY4"/>
    <dbReference type="STRING" id="387005.A0A183HFY4"/>
    <dbReference type="WBParaSite" id="OFLC_0000639501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000639501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000639501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000639501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10773" checksum="95DE92EDBE20314D" modified="2016-09-07" version="1">MAFCRSTLIERLLNNNNDQCTTTNSGILRSWNNIDSFERDNIMEVYRKLSNIEEQIWGKLIVMERNIRSAKAYLRSRIITIDGSEAEFDGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGW2</accession>
    <name>A0A183HGW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006560">
        <property type="protein sequence ID" value="VDO47672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGW2"/>
    <dbReference type="STRING" id="387005.A0A183HGW2"/>
    <dbReference type="WBParaSite" id="OFLC_0000672301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000672301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000672301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000672301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26619" checksum="48D479ECF7521EE0" modified="2016-09-07" version="1">MPIHGDLKQYERERHLEMFRSGRTNILVATAVAARGLDIPNVKHVINFDLPTDIDEYVHRIGRTGRVGNVGLATSFFTDRNRNISHDLMDLLIESNQLVPDWLEKMNKGNFRSSSKYYDKSHGGFLFNIRFGGHDHRLNVESNYRSTLVVQEFRNEPNSSWYTQTPINFYPSFNHGDTRSGVMNIPSTTFQSNMYRTPQPAHNYPPYGSFIPSVPTNGINYWCGAANTSQNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH12</accession>
    <name>A0A183HH12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rad60-SLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6776</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006640">
        <property type="protein sequence ID" value="VDO47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH12"/>
    <dbReference type="STRING" id="387005.A0A183HH12"/>
    <dbReference type="WBParaSite" id="OFLC_0000677301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000677301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000677301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000677301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8620" checksum="2301D29B79A2D25F" modified="2016-09-07" version="1">MERDKISANDKSPLYTSPSPLHIKRILNAKRQNSESILRVKVSGAEMCNIYRAFHGRLNVSYKRREDFEQGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH8</accession>
    <name>A0A183HHH8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="14" type="ORF">OFLC_LOCUS6939</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006918">
        <property type="protein sequence ID" value="VDO48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH8"/>
    <dbReference type="STRING" id="387005.A0A183HHH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000693901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000693901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000693901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF25">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO48564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000693901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28217" checksum="93752CAF04F7885C" modified="2016-09-07" version="1">VYLFAVLKLGKIYGAYVSVLYLFVKCLHLCNVILQFIMLNNFLETSSYPFFGGHVLYDLIMGREWHDSGRFPRVTLCDFEIRVLGNIHRHTVQCVLVVNMLTEKIFLFLWLWLLLLSFGTAVNMIIWTLSLSLADWRHAFVTKFLECESNQTHRFVHHFLRPDGVLILHMIASHGGNIVCARLTESLWMKFLQRSGKLTVFDVEKAVCPEERSGKNGNKHMDEGSWREPTLPPPMPLLTSTQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHM9</accession>
    <name>A0A183HHM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase_C_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6994</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SBNO family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007011">
        <property type="protein sequence ID" value="VDO48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHM9"/>
    <dbReference type="STRING" id="387005.A0A183HHM9"/>
    <dbReference type="WBParaSite" id="OFLC_0000699001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000699001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000699001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch helicase C" evidence="3">
        <location>
            <begin position="166"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000699001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33929" checksum="4E0F21E509597DAD" modified="2016-09-07" version="1">MSFFCQSLFELFMTTSNGAIHGDEDTWLQRLLDEAKSSDDETAEEKNGSEKEKEKSDEEEFNPFTCDFTREDPWATKQQIISDSPKKKKVKKKKFKKKQKKSIRRIDSTAMVRLIFGMLSMHSTADVFMSSSRLVSDEDLTLGETSIIKAELLAAVERLSPRLPPNTLDQLIDELGGPDYVAEMTGRKGRVVCREDGDVEYELRHAGADVPLELMNMDEKDKFMKGEKLVAVISEAASSGISLQSDRRAANRRRRVHITLELPWSADKAIQQFGRTHRSNQVSAPEYIFLISELAGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI70</accession>
    <name>A0A183HI70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7183</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007324">
        <property type="protein sequence ID" value="VDO49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI70"/>
    <dbReference type="STRING" id="387005.A0A183HI70"/>
    <dbReference type="WBParaSite" id="OFLC_0000718101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000718101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000718101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000718101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25757" checksum="5AF1427A5780064F" modified="2016-09-07" version="1">MKSREFGLAPLDERDERLWEDPFARLHLHLQNEMARLHQIAQNVLNLQRTQTVMPIIAATRPQGHEKNAMEGLRVGNNDKNGEKIIEVKPIESNKEQRLLGYEGENPTVMEVPESSLFSRLASRARRLSLSQWLVCVALFLCLISMLSISAAILKQIKSQKYFDLRNMHAVVPPTFAEPLATKKIPLESTAVVTDYPLIHDCPPPAYDQLSIHKEKSGNGTDNSDPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ04</accession>
    <name>A0A183HJ04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007820">
        <property type="protein sequence ID" value="VDO51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ04"/>
    <dbReference type="STRING" id="387005.A0A183HJ04"/>
    <dbReference type="WBParaSite" id="OFLC_0000746501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000746501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000746501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000746501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11593" checksum="34CD3214029CCAC3" modified="2016-09-07" version="1">MFLKSTKVSLPLRKWGSVDLKKVELKENTTQKKSKSSILSQNQASIGNTSPEDKKNKAKVAKKGTVARATTSNLSESAEAASSRLTSTSSARSSILTAKPSKRKMSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ75</accession>
    <name>A0A183HJ75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7537</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007936">
        <property type="protein sequence ID" value="VDO51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ75"/>
    <dbReference type="STRING" id="387005.A0A183HJ75"/>
    <dbReference type="WBParaSite" id="OFLC_0000753601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000753601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000753601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF285">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000753601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21190" checksum="4BF6F9988B416644" modified="2016-09-07" version="1">MEQLPQVVETGIVRCPLCREMITLPSGGSNAFPSSFLINQLLDLMQKQRKDVVPNCSIHQQEQLLYCEACDLVFCQHCSSSSTRDCSDHTVIPFSIAIKRLSEIVVYKANQCVASLNTAAANVKCETLQLDRNVDNVVDGLNAAFQEICQLVENRRRELIDAVRVMRDEKQKVLRDQTELIDSYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJS3</accession>
    <name>A0A183HJS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7735</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008260">
        <property type="protein sequence ID" value="VDO52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJS3"/>
    <dbReference type="STRING" id="387005.A0A183HJS3"/>
    <dbReference type="WBParaSite" id="OFLC_0000773401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000773401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000773401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO52346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000773401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22620" checksum="557608A57ABD3C7A" modified="2016-09-07" version="1">MLGNMIGASTLTYLSDKFGRRPVLISSLLVLGIIGLLTSFAENILVFIIGRFIQGFCSPGPLLVAWVLSYESVPIGLRGIVTLMYGVMWVVGYCAVAPLNYFITNWRWLMVAYSVPSIIIAGLYFFIIPESLHFLIVNGRKQKAAKWIRNAVKYGKVLHKKSIDMMVELLENKSSDVKMEENKKEIIEENMRLVIVSSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKP4</accession>
    <name>A0A183HKP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial-processing peptidase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8054</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008830">
        <property type="protein sequence ID" value="VDO53818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKP4"/>
    <dbReference type="STRING" id="387005.A0A183HKP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000805501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000805501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000805501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO53818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000805501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26558" checksum="7C8347B0A2BB7AA0" modified="2016-09-07" version="1">MSVSFLLLHNLFHIIRKDGFFQVGIWIDAGSRFENDKNNGVAHFLEHMAFKGTMKRSQSALELEVENMGAHLNAYTSREQTVYYAKCFSQDLDHAVEILADILRNSQLRTVEIERERGVILREMQEVEQNLQEVVFDHLHAGAFKGTSLARTILGPVENIKSLRREDLVKYINEHYRGPHMVLAAAGGVDHQKLVDLGQQYFGDLDGVDDNFVAESGKFVSSYVRYFSFFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL19</accession>
    <name>A0A183HL19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8176</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009037">
        <property type="protein sequence ID" value="VDO54388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL19"/>
    <dbReference type="STRING" id="387005.A0A183HL19"/>
    <dbReference type="WBParaSite" id="OFLC_0000818001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000818001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000818001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552568" evidence="2">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000818001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17059" checksum="990A4DC31D93E7D7" modified="2016-09-07" version="1">MYMSLIMCHLQLGPLFTMPVSGALCVSSFGWPATYYIHGILTLFIMFIFYNIYRDSPKIHKNVSSKELSKIEFGKEVTYVKKIPKVPYKAIVHDLSIWGIWVASIGGTLGFQIFFQYGPVYLNEVGFSFRFFFLPSLLFNIILKKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLU8</accession>
    <name>A0A183HLU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8465</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009590">
        <property type="protein sequence ID" value="VDO55778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLU8"/>
    <dbReference type="STRING" id="387005.A0A183HLU8"/>
    <dbReference type="WBParaSite" id="OFLC_0000845901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000845901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000845901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO55778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000845901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15271" checksum="6DABC0D0C025E7C8" modified="2016-09-07" version="1">MPKTRNILIGVCGIGAVTLIGLIVVVVYISNEIRAAENELDIEMETFKLKASDLWKNMMSMNITHRQRRQLSSSDESPDVTGSLSKESPDVTAGPQEQSKRSDSYEKESSENVKGKNNCPPGPPGPPGPNGMDGYDGMDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMH2</accession>
    <name>A0A183HMH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTP_transf_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010026">
        <property type="protein sequence ID" value="VDO56897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMH2"/>
    <dbReference type="STRING" id="387005.A0A183HMH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000868301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000868301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000868301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF117">
        <property type="entry name" value="PAP-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000868301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24634" checksum="A6D7D0710E2C5286" modified="2016-09-07" version="1">ILPPVNIHTTNIPSPHLHNSGSKYGTLCSTLGVRFMEETLAIRSVIKEKKAAFAKEFKLFDEHIWRHFEINGQDDRTFSWKMTVRQKLLTLIHQVYKDSNLIAVGSTVNGCGSYNSDMDLCICQPYENQSFEANRSYSIHVLRKLHKKFRTDWRQMFKTCQYIPAKVPIIKLEMAAPYEELEIDINCNNVAGIYNSHLLHYYSRYFSNFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN44</accession>
    <name>A0A183HN44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8907</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010459">
        <property type="protein sequence ID" value="VDO57958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN44"/>
    <dbReference type="WBParaSite" id="OFLC_0000890501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000890501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000890501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000890501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10296" checksum="563A44575D96C410" modified="2016-09-07" version="1">MIKNDEALIMDAVSQPLEILDFDHHFRRRECHRLSEAIVNEINHDDIVCITWNFFVMIGPFMILIALCIIIMATAIIYRKVHCRERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPR2</accession>
    <name>A0A183HPR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9472</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011637">
        <property type="protein sequence ID" value="VDO60871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPR2"/>
    <dbReference type="STRING" id="387005.A0A183HPR2"/>
    <dbReference type="WBParaSite" id="OFLC_0000947301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000947301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000947301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF241">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO60871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000947301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="13116" checksum="AF9F1F9F085F399C" modified="2016-09-07" version="1">NAGPPGYPGRNGNDGPPGPQGPPGPPGPPGEPGRDGPRGDPGRPAMSTPAAPGDPGMPGETGPPGLPGDQGPAGRPGPEGPQGMQGPPGPPGKPGQPGEDGQEGPPGHPGPQGERGICPKYCALDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQA9</accession>
    <name>A0A183HQA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012114">
        <property type="protein sequence ID" value="VDO62320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQA9"/>
    <dbReference type="WBParaSite" id="OFLC_0000967001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000967001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000967001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000967001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7904" checksum="2172A9315B8476C1" modified="2016-09-07" version="1">MYMSRHNALLFAGKKYAVHMIAHLLTNTGNIWGQSYICPTNTGNIWGQILRPLWIRQLVISSKGYDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQF8</accession>
    <name>A0A183HQF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012229">
        <property type="protein sequence ID" value="VDO62766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000971901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000971901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000971901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000971901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21613" checksum="8B32DFE2A1ADBF37" modified="2016-09-07" version="1">MGYIIIRNIANDGNVLKPIILDAVLKLWNLIQEIKIEGERNDSTFDYASICVKFPTSPEFDEIVANILMHKSFRLHEECVSNPLITAFKMFVNGDLNPKNDTIDKAILKLVANSFSSDLLINICNFLGGITFDEKHQISGHAENFCLFFFLQFHLFSNVSISFLIFEFLKTDYILKLQLTMLYFKITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS02</accession>
    <name>A0A183HS02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10274</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013511">
        <property type="protein sequence ID" value="VDO67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS02"/>
    <dbReference type="STRING" id="387005.A0A183HS02"/>
    <dbReference type="WBParaSite" id="OFLC_0001026301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001026301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001026301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001026301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21483" checksum="1B91E65D80B18784" modified="2016-09-07" version="1">MYLIVQYHNPLLSSHLESHKVTSFEYGRPFFAALFAPEICKQSLYVIWDKLFERGDPYLLFAMVLVFLINCSDQLMALNTKSELVDTIRFSVKELSINDVDDFLELSVLFLSQTPSSIKQDFQRVLFGSRHAEEIQTDIAKLLALPIDPRDVIRMGLDENFNAAESEPNFFIIDARSHDQYSAGHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS34</accession>
    <name>A0A183HS34_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10298</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013562">
        <property type="protein sequence ID" value="VDO67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS34"/>
    <dbReference type="STRING" id="387005.A0A183HS34"/>
    <dbReference type="WBParaSite" id="OFLC_0001029501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001029501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001029501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO67392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001029501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16808" checksum="C14B449426A68A42" modified="2016-09-07" version="1">MYDLRDMALTCKFKGAQNERSQIRASLSPDGKHIVCGSEDHFIYIWTTADLPSSLSVRKDRNDSWQRLRGHSACVTVAIFAPRPQLFLNLLEQRRGGDDRAEQSKPCKNISDRQIHGDVIISADLNGSIRIFVNRTKIKAGSSNFFPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS64</accession>
    <name>A0A183HS64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10324</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013645">
        <property type="protein sequence ID" value="VDO67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS64"/>
    <dbReference type="STRING" id="387005.A0A183HS64"/>
    <dbReference type="WBParaSite" id="OFLC_0001032501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001032501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001032501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001032501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="30894" checksum="543D9F86C2364F82" modified="2016-09-07" version="1">MSFYFFNFISQFFQTHENGSCSKLANLTTVTSTKPVDAEVGPTVATSSMPLLNEISEHILKLYTAAQTAAVAATALTAAPTTSSTTVTQDSSILPLQVPVVGANGCYTGQSSGTSLINPQLQSLLALQFVASQLPLTESYRVPILTNPSSHGASDIRWKPVYETQSSVLPSVPIIDSNKSTADMKQHAIVTDGSFPNKDAPISSATNLDIPSCTTNKTGTSLERLLEQTLKEPVLSVAKLLVTEFRREKELLLNQNGQLRRENALLRSALASSTVLVGLKGLTAANVPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSN3</accession>
    <name>A0A183HSN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10493</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014042">
        <property type="protein sequence ID" value="VDO68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSN3"/>
    <dbReference type="STRING" id="387005.A0A183HSN3"/>
    <dbReference type="WBParaSite" id="OFLC_0001049401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001049401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001049401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001049401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10146" checksum="68C9BD04775B110A" modified="2016-09-07" version="1">MMPECDCRTIPLMQNPRLVTDRTFWPAPFVKPKRASRTCRSVTPSKIDKCSRFFFPMLFFAFNILYWTIMAVLSSFVDTSDYTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTM5</accession>
    <name>A0A183HTM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anacyclamide/piricyclamide family prenylated cyclic peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014909">
        <property type="protein sequence ID" value="VDO71723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTM5"/>
    <dbReference type="WBParaSite" id="OFLC_0001083701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001083701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001083701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001083701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3699" checksum="60283C36DC090B66" modified="2016-09-07" version="1">MAIKPSNQQAANNQSVRMECGSFRVDCEKERGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU60</accession>
    <name>A0A183HU60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11022</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015376">
        <property type="protein sequence ID" value="VDO73174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU60"/>
    <dbReference type="STRING" id="387005.A0A183HU60"/>
    <dbReference type="WBParaSite" id="OFLC_0001102201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001102201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001102201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO73174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001102201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14431" checksum="948846762E73613F" modified="2016-09-07" version="1">MIGISEPFDQPAGPPRFLKCMRDIWASLGDNVEFEVEVSGYPLPELTWYHLDEKVLEKKNVQISYITPTKCQLKITNLSVSHLGTYSVEASNIHGIVRTTASLNVGKKRDEAESSKSLEGFTFDFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUF6</accession>
    <name>A0A183HUF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11125</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015657">
        <property type="protein sequence ID" value="VDO74053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUF6"/>
    <dbReference type="STRING" id="387005.A0A183HUF6"/>
    <dbReference type="WBParaSite" id="OFLC_0001111801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001111801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001111801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO74053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001111801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6587" checksum="ED73DA3A095ABB6B" modified="2016-09-07" version="1">MQQSFHAIPQQELPLGPRIIHLNRGMQGLGFNIVGGEDGEPIYISYVLPGGVADLSGNVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUN4</accession>
    <name>A0A183HUN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4834 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015862">
        <property type="protein sequence ID" value="VDO74624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUN4"/>
    <dbReference type="STRING" id="387005.A0A183HUN4"/>
    <dbReference type="WBParaSite" id="OFLC_0001119601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001119601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001119601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001119601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8960" checksum="10A40E7A6BC3B871" modified="2016-09-07" version="1">MGNIIFPIFLTQHAEQLIQNSGNYQDQLESSVSIQNTSQIQKSKLQREDTHGFDEYDEEDFRRDNTYESHRNYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWZ4</accession>
    <name>A0A183HWZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018059">
        <property type="protein sequence ID" value="VDO81083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWZ4"/>
    <dbReference type="STRING" id="387005.A0A183HWZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001200601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001200601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001200601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001200601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7659" checksum="10299F3CBCC0D257" modified="2016-09-07" version="1">MEKESIVERQEQKPVVDGAQSGNYNLVNFNLEEVEEEIRLEKIRQTSVKFSWDYLSQLLRRNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXB9</accession>
    <name>A0A183HXB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MMS1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018434">
        <property type="protein sequence ID" value="VDO82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXB9"/>
    <dbReference type="WBParaSite" id="OFLC_0001213101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001213101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001213101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001213101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13238" checksum="9D5C86665118242F" modified="2016-09-07" version="1">SCNTLLIDCNDVLLVLLLGRGERLTLDDADVDERDPILSGDLGGIACDNGIGVIGFDFLVTIFDVVSLEMVPSVSLQTSTGESGVDRIRKVYKCPLRGAKNGKILAVSFGRPQRPLRMVVKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXR6</accession>
    <name>A0A183HXR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018864">
        <property type="protein sequence ID" value="VDO83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXR6"/>
    <dbReference type="WBParaSite" id="OFLC_0001227901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001227901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001227901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001227901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="4012" checksum="DD2A69F0FB75B7EF" modified="2016-09-07" version="1">MIRNVARNCSEKHFIVRFPLYQIVYRKYHICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXW4</accession>
    <name>A0A183HXW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019013">
        <property type="protein sequence ID" value="VDO83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXW4"/>
    <dbReference type="STRING" id="387005.A0A183HXW4"/>
    <dbReference type="WBParaSite" id="OFLC_0001232701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001232701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001232701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001232701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23766" checksum="C1F0A40D5C2C89F4" modified="2016-09-07" version="1">VLSLTGSSHHVAIGGSSAVVLSVTQQPFRHTVATRRTLRPSRETQAGSSMTGERVSNNVVEIDSSGSSSSSLRRQHLFTRSYRTSREHNLAIRCLSNASSSASHTMVVEVNGSRSRTQSNANPMGTCYEDMFRPSRFDQIVNSSPPPREVMEAYAWNPDDRSLNIFVKDDDRLTFHRHPVAQSTDSIRAKVIVSFMKFGNSCCFSFLRIFSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ58</accession>
    <name>A0A183HZ58_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12770</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039927">
        <property type="protein sequence ID" value="VDP12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ58"/>
    <dbReference type="STRING" id="387005.A0A183HZ58"/>
    <dbReference type="WBParaSite" id="OFLC_0001277101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001277101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001277101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17187">
        <property type="entry name" value="FERM_F1_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="8">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001277101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="40083" checksum="E593F8809C40006C" modified="2016-09-07" version="1">MSKKAKLYWNWSGQKVKINVRVTTMDAELEFAIQPSTTGKQLFDQVVKTVGLREIWYFGLQYTDTKGFLTWLKLNKKVTAQDVKKEQTLLFKFRAKFYPEDVQEEIIQDITLRLFYLQVKDAVLSDEIYCPPETSVLLASFAMQAKYGDYNPETHKPGCLTSDRLLPQRVIGQFKLSPEEWEKRIMVWWADHKNTNREQAMMEYLKIAQDLEMYGVNYFEIRNKKGTELFLGVDALGLNIYEKNDRLTPKVGFPWSEIRNISFNDKKFVIKPIDKKANDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKQQAKEERMQRQLEQERLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0J5</accession>
    <name>A0A183I0J5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GLE1 RNA export mediator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13257</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040112">
        <property type="protein sequence ID" value="VDP13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001325801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001325801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001325801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001325801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="61446" checksum="A6F4F32280DA66E1" modified="2016-09-07" version="1">SSFIFYFSKSYVPESESVLGPLANISNSIPDDSMFKPAVLIESTSKSLLPIEASTSVCFTKPSAIIDTSISNMFSASSSVTVANLTSTVPSICDRMIPKIITSFPAHVTSTSPSSSYAVPKIQQQFDILSTSAFCPQKSSTLAFVSSLETLKGGHAVLTRTDSISSCRSSGSRSTSWSLQQIVEKEQSIPHDSSIIAAANRNESMTQSVSKIESNNSPVVRNGTSNDANVNSVNHCHEIYEHEINFARTFMANIANISDSVKNELKRTIKEKISVSTKKFAEENDIARIVRFFNNLLNGLTVYGFNDKMINLKNDKLARDWAMAHIIDTYLVIHWFXXXXLARDWAMAHIIDTYLDLIPQDISLLKVVAAVLSSLTSSSTTFSKLLFGKLFIASPLLAVNHNECLECISNLKRRSDRFAETIVAWRSREIAIISLFIALKMSNIIVGLQTIPENNGLGSMWKMIALTASKNSPFGATLITEILKQHWNILHAFYGRQMEKLITQIDRSVLPFWRASLRKITPGDSEMNETIQSVAENCLTALKFTLDDCLSSFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1D4</accession>
    <name>A0A183I1D4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13546</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040259">
        <property type="protein sequence ID" value="VDP14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1D4"/>
    <dbReference type="STRING" id="387005.A0A183I1D4"/>
    <dbReference type="WBParaSite" id="OFLC_0001354701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001354701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001354701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001354701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8577" checksum="0B3864E5A5105CB7" modified="2016-09-07" version="1">MTKATKIDDTSVIAHCKEEKSWLHVHHDEDSFPNYFENSSGLDEFGNVEFNDIQFQYDFRLHRKSIQMRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1F9</accession>
    <name>A0A183I1F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UEV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040270">
        <property type="protein sequence ID" value="VDP14100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1F9"/>
    <dbReference type="STRING" id="387005.A0A183I1F9"/>
    <dbReference type="WBParaSite" id="OFLC_0001357201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001357201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001357201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001357201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17530" checksum="CED46BE1210F622A" modified="2016-09-07" version="1">MTNNVVSSTVTALLDRAKAKYVDTAKNDILLALSGFPDLTPDVEHFVYPDRTYTLAFRLKGTIPVLYKGNTYNIPVALYLWDTHPYYAPICYVCPTPNMMLKESKTVDKQGRIYLPYLSDWSFPGYDLSGLLQVIFSLMRINYSIKKKKKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I286</accession>
    <name>A0A183I286_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13848</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040429">
        <property type="protein sequence ID" value="VDP14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I286"/>
    <dbReference type="STRING" id="387005.A0A183I286"/>
    <dbReference type="WBParaSite" id="OFLC_0001384901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001384901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001384901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF3">
        <property type="entry name" value="PURATROPHIN-1-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOS1/NGEF-like PH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001384901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25868" checksum="270EDDBFDA185FCF" modified="2016-09-07" version="1">MAKMTDCGLTEMVKDSKVKFELWFRKQKNSFTYVMESQTACIRDAWVEDIRNILWDQAIRSREKNLREKANMGIELHSSYIHLGPRATNIQYKIFFHHFSVFLLQLSGLRDFGFVEGTRRPCSLISLTASSCSSSNNLGRIQVGRGTCDIGGDLCRVEEGDEWESMHESSPTIKCAENTLPRFRAPPPPDLNQQSFPHFLLCECCLYIWRIIIPYSLAETSWTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2K1</accession>
    <name>A0A183I2K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13963</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040501">
        <property type="protein sequence ID" value="VDP15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2K1"/>
    <dbReference type="WBParaSite" id="OFLC_0001396401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001396401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001396401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001396401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="6972" checksum="64C4D742BDC8D3D9" modified="2016-09-07" version="1">MNNLGLCIPGSSSPSSITVATPIISCRPHHLVPCHPDGNKQNHNVFHTNLTSAPIQPLLMCMKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3B3</accession>
    <name>A0A183I3B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14225</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040687">
        <property type="protein sequence ID" value="VDP16067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3B3"/>
    <dbReference type="STRING" id="387005.A0A183I3B3"/>
    <dbReference type="WBParaSite" id="OFLC_0001423301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001423301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001423301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF451">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP16067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001423301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37447" checksum="9640B570783840EC" modified="2016-09-07" version="1">MAESRQQEIQMVDIEPRTLQALINFCYTGEITIADFNVQSILPAACLLQLNEVQEICCEFLKKQLDPTNCLGIRAFADTHACRDLMRIADKFAHHNFQPVRYGEVLYAVGGWCSGDAIASVERMDSRTGEWRCVAPMSKRRCGVGVAVLDNLLYAVGGHDGQSYLNSVERYDPATNQWSSDIAPTSTCRTSVGVAVLGGLLYAIGGQDGVCCLNVVERYDAHRNEWSEVAPMSTRRLGVSVSVLNGCLYAVGGSDGQNPLNSVERYDSRINKWIMVKSMNTRRKHLGTAVHDGCLYAVGGRDNACELSSAEKYNPNTNEWINVVAMNNRRSGVFLLIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3F8</accession>
    <name>A0A183I3F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040728">
        <property type="protein sequence ID" value="VDP16274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3F8"/>
    <dbReference type="WBParaSite" id="OFLC_0001427801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001427801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001427801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001427801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33748" checksum="C83D3FC2763DF754" modified="2016-09-07" version="1">MYANLLPPIHETLPSFRQSLPLLNETKVLESRRLQNQMTSTDVERSSDIFERNQQQHFTVQSSVITKNMIVMQDICSGSDSDAINNDTMYTQQQITAMVSDIDCMHKRRQQFATTERPNTMNAYHQDLMSATTVAENNNNHSDEQHYYTATTTGSLHQHFIHNDYTPSTQQQQMLMNARNATTLAERFPGLQGQTCQFIGAAGTDHNGGTGSYVIANQQSAGTCDYLDNTLSSGGSPVDNLLPCPKVTNSSVMSAKQHQHEPHRVNSEFDNGSFNGMNKDIEEDGTKLQLFCSGSQNVTLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3S2</accession>
    <name>A0A183I3S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14384</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040811">
        <property type="protein sequence ID" value="VDP16808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3S2"/>
    <dbReference type="STRING" id="387005.A0A183I3S2"/>
    <dbReference type="WBParaSite" id="OFLC_0001439201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001439201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001439201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001439201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45292" checksum="2ED0C3D029191693" modified="2016-09-07" version="1">MLWCKEKCDSSSSCYLGQDEIINYWITCFEHDCRLLNSQGYDIAGITFNLLKNNRTWKRNVIHFNEQEITHSSRKNIINDLCNNKCVTNEICEVTTGKCVCIADFIRINNGSCVSIPTTGSLPNSSFCTPEFEIVGPTTVQLPHDSAILSIKFADSHGIFCYIVPFFLEKDRLDGGKKKKTVLKAKFSEDQTDFTYYWEVLDGGGFGTASTYTEPTLILTNLKEGMMRLRVTTANSTCKSFKDATLRVLAEKHANKPPVALIRPSNQIHVNEGSHLVLDAEGSSDDSGQPLGFEWKLLNGPAISLPAMNTAVLRLDNLVTGNYTFGLIVRDKQGATDEKRAEVIVAAKRDDPPKALITVCGDPRSRSAIDIRLPQNSLQLCANTSTDDNVRFFCSIHYHLTELILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4H0</accession>
    <name>A0A183I4H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14632</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041023">
        <property type="protein sequence ID" value="VDP17972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4H0"/>
    <dbReference type="STRING" id="387005.A0A183I4H0"/>
    <dbReference type="WBParaSite" id="OFLC_0001464301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001464301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001464301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001464301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12302" checksum="6D3B25A3FC38CD7C" modified="2016-09-07" version="1">MNPLTNIRKQNKINERELLLGFTGSNSKSWHQKYSDSAWIYVGGLPYDLNEGDIIAVFSQYGEIVNINLIRDSKTGKSRGFAFVCYEDQRSTILAVDNFNGIKVCYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5J2</accession>
    <name>A0A183I5J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041477">
        <property type="protein sequence ID" value="VDP19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5J2"/>
    <dbReference type="STRING" id="387005.A0A183I5J2"/>
    <dbReference type="WBParaSite" id="OFLC_0001501501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001501501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001501501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001501501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10584" checksum="0BF9BE89F298F0CA" modified="2016-09-07" version="1">MEEPAEAMLDNLLLDNTTKKMMDNMTEWENLGQSVIMGKRAMIELDERRQKCREALGQLRKQAKNTTNKRWGKGCNVMSGIEKKTSDLWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I677</accession>
    <name>A0A183I677_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS15239</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="EMBL" id="UZAJ01041813">
        <property type="protein sequence ID" value="VDP20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I677"/>
    <dbReference type="STRING" id="387005.A0A183I677"/>
    <dbReference type="WBParaSite" id="OFLC_0001525001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001525001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001525001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001525001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35501" checksum="BB5C3D9A6AB3CC5D" modified="2016-09-07" version="1">MLHMKLYIINTIGKRFAVIGIENNAKNRKNYRHLLFTTTNISQYISGIILHEETFNQKDDAGKSFVDIIREAGILPGIKLDKGLRQVDGSSEYITSGLDDLKERAKYFKKGGCQFAKWRCVYVISKVTPSRKIMKENAKILAQYAVSTQQAGLVPIIEPEVLCDGEHDLERTEKVTEQVLAEVYKSLHDYNVYLEGTLLKPNMVVTGLKSKEKVGHDKIANKTLTALLRTVPAAVPGIVFLSGGQLESDATRNLNEINKITINKPWKLSFSYGRALQTSALKAWMRHGPKEAQAIFRQRAKLNALAAEGNYIDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Z5</accession>
    <name>A0A183I6Z5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS15507</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01042273">
        <property type="protein sequence ID" value="VDP22250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Z5"/>
    <dbReference type="STRING" id="387005.A0A183I6Z5"/>
    <dbReference type="WBParaSite" id="OFLC_0001551801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001551801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001551801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP22250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001551801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25861" checksum="A01F254C92AB3812" modified="2016-09-07" version="1">MKTVYETTKESLKRIGELGSGTCGVVYKARFEQTGTIMAVKVAIASFEVLICMELMATCLDKLSKRVQGGFPEDILGKMAVSIIKALDYLKVTQNIIHRDVKPSNILLDLNGTVKLCDFGIAGRLVDSMARTRTAGCSAYMSPERLEAQEEYDVRADVWSIGISLVELAKGEYPYHGCNSEFEVLSRIVADPAPVLQPEEGFSPMFCDFLRLCLTKDYHFRPKYKELLVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I701</accession>
    <name>A0A183I701_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15513</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042282">
        <property type="protein sequence ID" value="VDP22295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I701"/>
    <dbReference type="STRING" id="387005.A0A183I701"/>
    <dbReference type="WBParaSite" id="OFLC_0001552401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001552401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001552401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP22295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001552401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="16269" checksum="3E3066FD29271AE7" modified="2016-09-07" version="1">MENTSNLTMRLSKLRAIQEIIRVLKSGGQACITVWAYEQNLCDEPSEYLKMRRKKRNVQMNRRDNHGRLRVHEGKEFTQPDMLVPFQNADGSRFLRYYHLFRDFELEDLINDVRGCIIEKYFYEQGNWIAYIRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I754</accession>
    <name>A0A183I754_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Charged multivesicular body protein 4b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15567</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042378">
        <property type="protein sequence ID" value="VDP22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I754"/>
    <dbReference type="STRING" id="387005.A0A183I754"/>
    <dbReference type="WBParaSite" id="OFLC_0001557901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001557901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001557901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000001">
        <property type="entry name" value="Charged multivesicular body protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001557901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25139" checksum="862E947B4B3F47B2" modified="2016-09-07" version="1">MSVFGKIFGSSKKQQAPSATPQESIQKLRETEEMLVKKQEFLEKKIEAEIASARKHGTKNKRLALHALKRKKQFEKQLQHIDGVLSTIEFQREALENASTNAEVLQVMGSAAKALKTAHNDMDVDQVHDLMEDIAEQQEVANEIAEAISNPVGFGQDMDEDELLKELEELEQEELDKQLLDVGPTPASVSALPEAPTAELPVSGKKVAAKKQQEDDDLAELEAWANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7C3</accession>
    <name>A0A183I7C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphofructo-2-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042512">
        <property type="protein sequence ID" value="VDP22972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7C3"/>
    <dbReference type="STRING" id="387005.A0A183I7C3"/>
    <dbReference type="WBParaSite" id="OFLC_0001564801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001564801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001564801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF70">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001564801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9510" checksum="FD700CB066D69CC3" modified="2016-09-07" version="1">MELERQSNVLVVSHQAILRCILAYFDNKNYSELPYLNVPLHTVIKLTPKAYSCQVEMFKFKIDAVNTYRSKKGQQEPLQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7T7</accession>
    <name>A0A183I7T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042907">
        <property type="protein sequence ID" value="VDP23932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7T7"/>
    <dbReference type="WBParaSite" id="OFLC_0001581201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001581201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001581201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001581201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19351" checksum="58E0688BB6B99659" modified="2016-09-07" version="1">MDWSFILQVANAQAILSAVYIDSMSVDSNVSDEFVSCYIFPMDNLSAYLCLLWTESCAMAKLSVCDRLLHYVYHSIGRLYVDRVLLLIRTLGRSILQYILFKYFNLYSFLKRKRIPVHGFPSNPVLGYALGEGLCLMGTVFTGIFGLIGCCRGFGRLFYAQEKMMLVCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8A7</accession>
    <name>A0A183I8A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15969</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043403">
        <property type="protein sequence ID" value="VDP25487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8A7"/>
    <dbReference type="STRING" id="387005.A0A183I8A7"/>
    <dbReference type="WBParaSite" id="OFLC_0001598201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001598201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001598201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001598201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24765" checksum="562384E1025677CF" modified="2016-09-07" version="1">MKNSACVDVKKPIDDGRRSVIKDESKTLENSDKAKEEQEESLPLTFPEAALATKTEIPDEILLSQCTDNGLQIVAADTSTEDEESPTNRSSTSVRSTSSKRIGRGKGESRGRGRRRKASTPLRSNEDVIARASSEVRRISAELSDEVPNLVVDDVEPTSDEEKSSSRQENATRSHRGRSRGPGSARGTRKKRTAASRKTIPVNNSDTSDKNNRSTKGRKRKAVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8C9</accession>
    <name>A0A183I8C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyco_transf_7N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15991</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043495">
        <property type="protein sequence ID" value="VDP25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8C9"/>
    <dbReference type="STRING" id="387005.A0A183I8C9"/>
    <dbReference type="WBParaSite" id="OFLC_0001600401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001600401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001600401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001600401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9867" checksum="DFF258081BCAFDD0" modified="2016-09-07" version="1">MHMVRQNLNLVNCPVTPPGLIGPIKVWYDKPTFEEIERLNPYLESGGHGKPKNCLSRHRVAIIVPYRGHIRFDVYPRSLIHHEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8H8</accession>
    <name>A0A183I8H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe_hyd_lg_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS16040</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043743">
        <property type="protein sequence ID" value="VDP26363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8H8"/>
    <dbReference type="STRING" id="387005.A0A183I8H8"/>
    <dbReference type="WBParaSite" id="OFLC_0001605301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001605301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001605301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP26363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001605301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25709" checksum="F7AA5725D1D5DE0D" modified="2016-09-07" version="1">MPCFDKKLEAARSHSGNHSYYREVDCVLSTGEVDEILDEYNTAENLFVSEKINWLNALENGKVINSEGGSSGGYAEYIVKKFVAESERPVQLKRTTKDKNWEIIEAVDKETKVLTVAKCYGFRNIQNQVQKLKRSKCDYDYIEIMACPSGCINGGGQIRGASSEERKQILDAIELLSSDDSPEMEEELERVKKEWSILNPDWMNLLYTQYHAVEKSEADRISTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8J8</accession>
    <name>A0A183I8J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043841">
        <property type="protein sequence ID" value="VDP26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8J8"/>
    <dbReference type="WBParaSite" id="OFLC_0001607301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001607301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001607301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001607301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4982" checksum="7E7C93D3CB0AD0AE" modified="2016-09-07" version="1">MFWEIWKDEYLTSSRERTQMEHKSPRSVEIRVLLIFYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UQN0</accession>
    <name>A0A3P7UQN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002573">
        <property type="protein sequence ID" value="VDO37491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H894"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="205" mass="24303" checksum="2A514B44892998E7" modified="2026-01-28" version="1">MFTLSLYLLLCSIYLVNSRTITIRIPDDINPDLPYETATEQFVRSDQNGDSKLSFDEYLHLDLPYEIMKKYEFEQIDKNNDGFVSRSEYDAKEKLRQKEIDEKRGQYYSRIFEEFDKNSDSKLDMKEVRNILAQRYALKPRSSFQSIFDSFDTNHDGGLDLREYVKFDNNVPFEEMDLLDHDSTSSEKVVKEKLPMQKLKLLVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V7B8</accession>
    <name>A0A3P7V7B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000872">
        <property type="protein sequence ID" value="VDO30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V7B8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126950" checksum="8C2ABBE980B36690" modified="2019-02-13" version="1">MLFFLGTWQTRFISLIIRGDLFTLHTGKVFVEETTTIEAQSFNNCGVWKIKEAIKIMLKGSANFYVSSKFSANLLKLIAEGQCTIAGHLSLENLLVYIRNDMITVPGARINITVGATVAVGTFRNDSSWYLDGNLHLHVACIEQSEDALIFVKDTFTMVVYDVSEERCQGRIVANYLIVNLMKQVRFDGYIRVNQIEISIPHVNESRLTIGGQLEVLDGPLILKGRSSEDFEISPFLKSSTVSSIAAHSYPAFILDGQLKAEAIIAPFLAIRFSTSSYSSLSGMDSIAKDATYRTLISCNSLHTQRTSLIDSVPTGLFPEGILCATTWLHEGQIRFNGGKVYIITDGLINRGRLTSGDKLQNHMHEVVVLVENFFRNDAVFSADRIEISGNGELQNMNRIFASDEMNIRLANFRSEFGQTQLEGTKLLSARNEWNHVMEGRIEACGNYDVSTSKACLALNHKFDKHVRINARSRLLIDNDIIDDRGNIALIARDAILFKSRMTVDLLELTLGAAYITEFVVKKGASVTTNQLRITGSCKYLTVIIDGELTCESMIIDARIRQVKMVGAGILSCRKSCNIGGDSIILTTRDIRMTELMGSLVTIVSDGTLSLSSFDSCLKTLSIYADNCYLQGRIFVEHKIILKIDHGACHISGEILGICANSELSLECDNLFLTGTIANLDFFESYTRKKIEHCETGMIKSVKNIVFEAELISLDGKIIDSESVIATGEEVNIEGILLQSQENTNFAYSIFGKKILFDGKIHGPARLELSGSEITFSGVSTNLKLLDIDANLAIITPRKMKCEIFNFIAYSAILDGNFNIAIFGVIIQTALFIRTDLTGCTQCKLVAPIILALNCPVSPKLDICSLIYAFERFELESGKFMEVFGSKHQFIWPSNNNSSPLVDTQQYSSNNASKLSQSFIEISFHSGIINHYAVKNSDLWQKTTKIIGECFKNSHTTSYDELEEALKKTKQMKPVGISLPTTSRLYLILLELLNEIHIEHILMRNFPKLFHLLCNITDIDDDDDEMKYSEIFVEQRERFDSQALHEIANRFRMRSCKFGLQRTEHHSAEDDIGYVSRSSSEEIDEKRRNINDLHDTLYCTNLDKESLTSISKVTISDEDDCMDKDAITDDELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VAP1</accession>
    <name>A0A3P7VAP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000595">
        <property type="protein sequence ID" value="VDO29073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="86" mass="9853" checksum="6D3D0A2B294ABB03" modified="2026-01-28" version="1">MLLHQENRENVTFVTEERVDVESLQAADRAGRMFSRVEKLSPGPSQLHAALLFFVNILIALHCSVWLIPKQKQDETSTLPPFHEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WAZ0</accession>
    <name>A0A3P7WAZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007999">
        <property type="protein sequence ID" value="VDO51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WAZ0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018045360" description="Nucleolar protein 6" evidence="2">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="4">
        <location>
            <begin position="171"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="254" mass="29142" checksum="A4ADA8BCA3F135D0" modified="2019-02-13" version="1">MHCIKILVFFLVLIILYRYSPKPFPPLSTNAVIERHSAFIKDSIAFPLSHISPPYLPTVKVLITMEQSGKWGDELGAIARLKTAFYIELSKILREKHSMQAIPFDDHLIIHFNTVVFRLVIAYPKEVHIMRKLNSDKTGILKDSAASKLKELDVILEPQLTALLHSASQQFEAFADTCRLAMYWLSSHALSDYLNEVILETIVASVFLKPFSIQPPRTPFVGFFHFLMLLSTHNWLMKPLLVDFDNEWTGLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XKI2</accession>
    <name>A0A3P7XKI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000718">
        <property type="protein sequence ID" value="VDO29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="172" mass="19702" checksum="69DDEC60D6B6B797" modified="2026-01-28" version="1">MMNKATIYEEAQGDLHEVDIYRDTAVRFLGYANEVGEAFRAWVPTNTVRLSYVIAMGYVFSDTADKSRKTYQLNYINSKERYRSVAFRAVDTLVWQSLASVVIPGFVINRVCYLSTKLLNWSTKWPLKVQKLTSTVLGLCTIPFIVKPIDTAVEIGMQSSIRKYYPMGIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XNY9</accession>
    <name>A0A3P7XNY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011460">
        <property type="protein sequence ID" value="VDO60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HPI0"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="176" mass="20314" checksum="2E56953088AF1B5D" modified="2026-01-28" version="1">MSQEASKTDNCFYYFAYGSNLLDERIHLQIKSAEYVSTGVLLNHRLEFYDHGLRWMGAVASVEQSKGDEVWGCVWHVPWSFSDELDKQESNYHRLDVNVKVENSTIVCRTYQYSNPNRQRKLPSPHYKLVIISGAIEHSLPSDYIKKLKAIKDNGYKGPIALDLIVLKYLNSNTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y4U5</accession>
    <name>A0A3P7Y4U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002146">
        <property type="protein sequence ID" value="VDO35952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H718"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="322" mass="36850" checksum="B22E2BAEC62AC255" modified="2026-01-28" version="1" fragment="single">TSTDPNCKDVTVVAFIIYPAAANSFNVESLKGQAVCKQLHNTVSRIKENLASRMFEACLKGRIPEMDDLLLPDERIQLKRCILSAKRDNLPPICTHNMIDDACDPVLNAFRRTQLINQPFDRVKVIFHPEFLSSVSPLMNLDYEDFVRGCHMGVFPSYYEPWGYTPAECTVMGVPSVTTNLSGFGCFIQEQVQDPHAFGIFVIDRRFKEPNESINELAKTLYDFTLLSRRQRIIMRNRTERLSELIDWKTLGTFYREARRRALEVTHPNFKQVIEETVKKMSRPNSAPSTPTTSRCVTPHESDDSDTSEQEEFEAKAWAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z1W1</accession>
    <name>A0A3P7Z1W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005512">
        <property type="protein sequence ID" value="VDO45182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HEX5"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="238" mass="28418" checksum="51BBC34D5E89878D" modified="2026-01-28" version="1">MESKSVVSNAVPESSTSVSKHPSKDSLKERFRILHQKRQESRKLNYEQVVEEDHRSKLPKNYDLKRKRQEWELEQMELRKAAEERGEDYDRLQALKTQADLIEQKEIVKRKKKPDKGFSDYEAMTLRQYQRLSGNIKPDIKAYEKMRQVIDANEFYPSVNTLISGTYYPTDAALNKLADDIKAQEKKRDQYHRRRMFDPDAPIDYINERNRKFNQKLDRFYDKYTEDLKSDLERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BCS4</accession>
    <name>A0A3P8BCS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042878">
        <property type="protein sequence ID" value="VDP23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BCS4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017996336" evidence="1">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="146" mass="15861" checksum="E65DA44B721EFF22" modified="2019-02-13" version="1">MFFRISYFLVLSGVVDQTCLIPSSPGYDPTAAAAVQPPITPIFGPQVIAPQVHAQLATVPSTSIVHNVTPIALHLHGLSPSVTSNYAYFLPHPAHHMIQPLMGLRLPTTPVQYMSQDIPFPDQAFFPPLISDIPENIQSSLDELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BRN6</accession>
    <name>A0A3P8BRN6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RYYR-CCHC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041647">
        <property type="protein sequence ID" value="VDP20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057001">
        <property type="entry name" value="RYYR-CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23674">
        <property type="entry name" value="RYYR-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="RYYR-CCHC" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RYYR-CCHC" evidence="2">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="387" mass="44610" checksum="5E27EEBA88236244" modified="2019-02-13" version="1">MHNIQSFSFFFFFFFVPTISNTLVSHYLFLLIRLISTDGVKTKRYQPYVKTLHGKLIGNPYPEHHPNCHTVTKEVQELQEMDRAXXXXXXXXXXXXXXXWNLRIEDNSNIDVHPGYNLRKRPRRLSFKFNAQSNDINESGLFISDACLNDISDTADYRSIYSIGTSSSNNISYSSLIVPELDGMSVRIYDGDGKLTNQGMTHYYCSRCDDFCQKRDDESLRVILKAENDLVIDYPVHHPECLPTPLESLRELGDQLKDFSVVANHRIIPLKAVLVSILESEYGIFHEPNESFFNGGSDEQNWNAADMDDEMLVNSVSVPKPQDHRCFCKRLYEENMELYQEMLRSVDEMRSLISEMRRVSGANAEYYIEDEQVLEGGDSNTLYVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BZ39</accession>
    <name>A0A3P8BZ39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018197">
        <property type="protein sequence ID" value="VDO81448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BZ39"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="164" mass="19052" checksum="3F209033543CD1B8" modified="2019-02-13" version="1">MYFFTKNDLCCSVKESCENIQIFGYNKESFAIKIILQTKKKEEFDYQYGYVERRSNLGKLMKKKANDWILHSFINGIKQAFPILSWLPNVSRSDLIKDIIAGITVGVICVPQEKKNEHEIFLSNLSSSLSSFIVLFIDYKNIYTLVGKEISDLIFSKIREMLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C8U4</accession>
    <name>A0A3P8C8U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040393">
        <property type="protein sequence ID" value="VDP14645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="91" mass="10563" checksum="34A4A04ECFBEECE1" modified="2026-01-28" version="1">MMGQFFGKVKEEKKEFLREDDVFSTPTRPNKIIRRVEMDPRSPTTTIPRTPIEVESTPKSSDSSRTPPKNKKKQQKLREKLLRKSNISSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CG31</accession>
    <name>A0A3P8CG31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041102">
        <property type="protein sequence ID" value="VDP18304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4N8"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="185" mass="20836" checksum="F4F78FBFEA85D489" modified="2026-01-28" version="1">MANAIQRKIAVMGYPCVGKSSITLRFVYGNFPDAYDTTIEDIYTKPYKFNGKQFALQITDTAGQQEFSLFPRSCAIDIDGYILVYAIDDRKSFEIVQSIYDKIMENLGDKNIPIVVVGNKLDLHFNARHVSTEEGRQLAVSWNAAFLETSAKDNTSVEQIFNCLLREIEIANGNMKRNQNGCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ENI7</accession>
    <name>A0A3P8ENI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040155">
        <property type="protein sequence ID" value="VDP13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6146649at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="122" mass="13972" checksum="3E79F600134FA209" modified="2026-01-28" version="1">MFTWSEDVKSLPGPVGVKYDDSMTVLKIHLVVMGIKEKTMVRAANTDVHLKYNEESLSVLLEVFKLNKKTKPPMKTVLERRFFEMQKCPSKILSVDFKLKKDQCILSVRKSLPGLWSNALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYD6</accession>
    <name>A0A183GYD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS246</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000071">
        <property type="protein sequence ID" value="VDO25125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYD6"/>
    <dbReference type="STRING" id="387005.A0A183GYD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000024501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000024501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000024501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883:SF2">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO25125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000024501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18155" checksum="CF5E6895B9D1385C" modified="2016-09-07" version="1">MMKLLLAKKILEHNRNKERRKEEKEIKARQERIRQAQEARKKEEQEEKKNEAFLQHAGNAGGSSGFNMPKGFEKIFQDSEVMNLLQDEGVLAAYMDIINNPANIAKHMSNPKVMKLFSKIGNATGGFGMDSGKPEMKETTAKDETTTDIPPPNKAPEPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYJ3</accession>
    <name>A0A183GYJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS303</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000088">
        <property type="protein sequence ID" value="VDO25321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYJ3"/>
    <dbReference type="STRING" id="387005.A0A183GYJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000030201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000030201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000030201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000030201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27284" checksum="919409B57553F9A1" modified="2016-09-07" version="1">MNLVFNEQRKNEFAIFEVANVAMSTSFVTPPSKSPVPPMAPRKKKTDKKSLKTANSPSYFPKTIDSPSFFPKKSLTMRHVLPKEHRLFHPPTASILSMVLRSAAKPRRSTRIKKNEKSENNEQENFLENQKKQKSWDFIMKIKTQKKKSQRDSNYSGENVKKKANYIVSIQKEISYCSVRVKQSNITSKESVVRGIYRLSDPNKKVANSCNTTRIVVTSRLCEAVSQSWILIKYETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYP2</accession>
    <name>A0A183GYP2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS352</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000110">
        <property type="protein sequence ID" value="VDO25497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYP2"/>
    <dbReference type="STRING" id="387005.A0A183GYP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000035101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000035101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000035101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043577">
        <property type="entry name" value="AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500139">
        <property type="entry name" value="AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552310" description="legumain" evidence="10">
        <location>
            <begin position="24"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="11">
        <location>
            <begin position="392"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO25497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000035101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="56072" checksum="6DB6C757C0FC0001" modified="2016-09-07" version="1">MFSLKKLSIYVLIAFLVSTSTRCINMKHFRNLKFSSLINFMLKFFSTESVHDKVSEKSQEKAKNWVVLVAGSKGWYNYRHQSDICHAYQLVRAHGIPEENIITMMYNDIAYNKNNPYPGKIYNGPNNRDVYTGVKIDYSGKDVTPENFLAVLVGNKAAVKGGNGKVVESSQNDHIFVYFTDHGGVGSVSFPNSMLTVKDLNDALKRMHKLKMFKRLVFYMEACESGSMFANVLPKNIDVYAVTASNSHESSWGCYCDNTMKLPCLGDCFSINWIVDSEKEDLNRETLASQFQIVKKETNLSHVMHYGDLRIGQDYVAYYLGDKKANVTNIYNNLIKVENEASVAWPSREIYLRMLKKHLDEAQTESERKTLQNKINKLEMIKVLINGNLSLFQKRAYLETFMKSLIWTVVPYQSYHEFIHSMPSSITSLDCFDDVIKAFHRLCFHFGHNPYVLKYTYIFANLCNAGINPEKIINAMFDNCGNIEIQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ67</accession>
    <name>A0A183GZ67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000183">
        <property type="protein sequence ID" value="VDO26100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ67"/>
    <dbReference type="STRING" id="387005.A0A183GZ67"/>
    <dbReference type="WBParaSite" id="OFLC_0000052601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000052601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000052601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000052601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34542" checksum="5EB1C9119A7B5866" modified="2016-09-07" version="1">MRNCYDVLGCSSVASYSQLKEAYFSKLRTNHPDKGGSSTALFLVTKAWSILKDENTRRDYNTWLREQLLRKNQGIIGQQIVIDSKVERVEDCGGEFIIEKTDIDRVVNSAYFECPNYVIHYSIYQCYKISGHNVIPSSTVGCAVSVIAHQYRAGTTEEQTELIELWDIGGSTVHQKASLNFFEGATGAILVHDLSNKKSESNLSHWVALLRGEPSLPSVISPFMSSSGARFLLSDIENTPIPTLIVGCKSDLAPERAKQTAYDRICLNCRRPISPGSTNRIILSKFFDSVVERKKLPIAGEKRRKIVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZE7</accession>
    <name>A0A183GZE7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS607</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000213">
        <property type="protein sequence ID" value="VDO26382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZE7"/>
    <dbReference type="STRING" id="387005.A0A183GZE7"/>
    <dbReference type="WBParaSite" id="OFLC_0000060601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000060601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000060601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="206"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000060601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="47676" checksum="0A1864473655ED81" modified="2016-09-07" version="1">MSEKAQDTTKQQLFEDVEKEVISKIPNLDIAQLRFLLSHPDIDPQMKKEKWDKLVELIKENEMGPYYKLVCDDIGTTMDELLFTELKEANEKRLKEIDDEIADAEQNLGESEVRQAYLRKSEYLCKIGDKDAAVASFRQTYEKTVGIGYRIDLIFNLIRLGLFFLDHQLINANIAKAKNLMEQGGDWERKNRLRSYEGLYKMSVRDLKGAAALFLEAVPTFGSYELMTYEQLIFYTVISAVYALERPDLRTKVIRCNEIQEQLTGGGENNELVSVKHYLEAFYGCRYDELFVVLAKLERERLKFDRYLAPHYNFYSRAMRLKAYEQFLTPYKTVRLDMMAKDFGVSKEFVDKELHRLIATGQLHCRIDAVRGIIIMNHPDTKNHLYRSVIKDGDILLNRIQKLARVINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZG1</accession>
    <name>A0A183GZG1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome maturation protein SBDS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS621</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000218">
        <property type="protein sequence ID" value="VDO26431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZG1"/>
    <dbReference type="STRING" id="387005.A0A183GZG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000062001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000062001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000062001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="111"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO26431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000062001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28843" checksum="407416D081AE2D1D" modified="2016-09-07" version="1">MANRIKTPTNVKLLTNVAVVRMKKCGKRFEIACYKNKVISWRNKTEKDIDEVLQTQTVFTNVSKGQVAKREELNTAFGTDNQLEICKIILEKGDLQVSEKERHAQSDSSFKEIANLIANMCVNPDTKRPYSSSVIENALHETHLSLKPNRSIKQQALEIIPKLRESMKIDRAEMRLRVSVEAKEAKRVHDRLKGMFTKIEVEDWEQGNLEMVGLIDPGAYRSVEELLQKETRKTGHLELLALKVVGEGDIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H052</accession>
    <name>A0A183H052_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS862</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000347">
        <property type="protein sequence ID" value="VDO27355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H052"/>
    <dbReference type="WBParaSite" id="OFLC_0000086101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000086101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000086101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000086101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4737" checksum="1B9F92D2FEDABC5A" modified="2016-09-07" version="1">MVHFSTIQEFFKTTAERMKDNRHAIQEEMSGPKCVAIPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0F3</accession>
    <name>A0A183H0F3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS963</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000399">
        <property type="protein sequence ID" value="VDO27728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0F3"/>
    <dbReference type="STRING" id="387005.A0A183H0F3"/>
    <dbReference type="WBParaSite" id="OFLC_0000096201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000096201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000096201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO27728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000096201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58018" checksum="9B82B1318ADD9A37" modified="2016-09-07" version="1">MTESRQTQYKNMGKDSEALRKNRMENIVSIRKDKREETLSKRRNIPADYGFVVNNEVEKSLGQARSLDSDDASTSAGGVVVNGTYNRNTLEDIVKKASSQDQEVQLSAVQQARKLLSSDRNPPIDDLIASGILPILVQCLSSNNVTLQFEAAWALTNIASGTSQQTQSVVQAGAVPLFLELLSSGNMNVCEQAVWALGNIIGDGPHFRDYCIQLGIVEPLLKFITPGIPIGFLRNDPPPSPEIVQTLLPALAALISHTDQNILVDTVWALSYLTDGGNEQIQMVINSGVSYLVVSNLIPLLSHPEVKVQTAALRAVGNIVTGTDEQTQLVLDCGVLQQMPALLSHQKEKINKVKCFFSNEAVWFLSNITAGNQAQVQAVIDAGLMPMIIHLLEKGDFQTQKEAAWAVSNVTISGRAEQVEYMVSQGVIPPFCALLSIRDSQIVQVVLDGLNNILKMAGPRSEAICTMIEECGGLDKIEHLQNHESEEIYKLAYEIIDNYFSETDDDGIATGDHFFESTQQNVPSEGFSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0G0</accession>
    <name>A0A183H0G0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translocon-associated protein subunit beta</fullName>
            <shortName evidence="11">TRAP-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS970</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAP-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000402">
        <property type="protein sequence ID" value="VDO27746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0G0"/>
    <dbReference type="STRING" id="387005.A0A183H0G0"/>
    <dbReference type="WBParaSite" id="OFLC_0000096901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000096901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000096901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008856">
        <property type="entry name" value="TRAP_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016400">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552320" description="Translocon-associated protein subunit beta" evidence="13">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO27746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000096901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22321" checksum="CBF485C9040C0DA0" modified="2016-09-07" version="1">MRWKLPIFLILCVTIVAIVYGEDADINDSAHIVASKFTLSQYAVEGMDYVIDYRLYNVGDRAALRVALDDRDGFPTQAFDVIRGLLQVRWERIGPGSNVSHSVVVRPRAVGAFNYSSAQITYYPTEDAKEVRISYTTAPGEGYIYRQKDYDRKFSAKVGVWLVFLMLVAPSTIIPFILWYKSKAKYDQETPLKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0P6</accession>
    <name>A0A183H0P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEHE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1056</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000452">
        <property type="protein sequence ID" value="VDO28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0P6"/>
    <dbReference type="STRING" id="387005.A0A183H0P6"/>
    <dbReference type="WBParaSite" id="OFLC_0000105501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000105501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000105501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000105501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51650" checksum="748FB44FD91E31DD" modified="2016-09-07" version="1">MSISYSALPQIVVPSVKSSGNELTNGTFDSNDTSSSSVDSLLALQRDDDLEFRIQQRLEASRQGMLQLEALRTKHQKLMQEIRICLPHRIGGELSNSDSCTKRKESLIMNPQTEIKLNDLRCDSPVSCCVSHRSSVSMDSGCVSLSSDFSSQSPMPCNTCRKFSLDDQRKKLEQNMAVENDENQQLVAMAIKSTTTQCCHRRKCSTNGRRPKSTCFNYPDENTVVVDSLSFSQITPPPVHRKFCMTGRSDSVQTHRPCLATSCIDIRSPISLQKQQQSPKHLPVNQSPMLHAKPISISLSSKIPTSPYMRLRDAQKSLKNSRVIQSGDNQSIFRASRIFVDHSSLIVQCPKHIERYDSDEESPRLLRAQPAVVLSRQEEFRLICRQQSYAHSNESSPCQLRKVHLTENSNSLSNGVVLEYHQQLNRCESSQSFETIVPDRTRRRKKEKDWKESEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V7</accession>
    <name>A0A183H0V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000480">
        <property type="protein sequence ID" value="VDO28313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V7"/>
    <dbReference type="STRING" id="387005.A0A183H0V7"/>
    <dbReference type="WBParaSite" id="OFLC_0000111601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10591" checksum="E79BB1EF894D1B09" modified="2016-09-07" version="1">MRFQGIKDEKLSVVSLSNRTSKKCYSKKAEIGLKIGIKKVIICEKEHINSKNSKDRKPTIEKIVLRDKLEIPRGRWELVKIKELKRGRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H150</accession>
    <name>A0A183H150_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000535">
        <property type="protein sequence ID" value="VDO28672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H150"/>
    <dbReference type="WBParaSite" id="OFLC_0000120901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000120901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000120901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000120901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19364" checksum="2FC2242173210E3A" modified="2016-09-07" version="1">MARFACHSRAVHAISVRVCNTLALHSSSFTYTRCSFCLTYHQSKYLLTLSISFHLITSGTIDETINHSILFIFNSVEIEKYPLTFLSALNCLKTAVVKANWIMEVLVCDYAHKQKLGDDCTCRKAILWYELRRAKPLDQEEAQTGRSYRANHDDSTIEVTSSAEMLSETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1A0</accession>
    <name>A0A183H1A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000565">
        <property type="protein sequence ID" value="VDO28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1A0"/>
    <dbReference type="WBParaSite" id="OFLC_0000125901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000125901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000125901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000125901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10252" checksum="6FFAFDA311B17C66" modified="2016-09-07" version="1">MSWKAVGNSCNDASWLPSWNVPFLCRKPARRLLYFSPAARSIHVAFQSYVTFLILSNGLAQIVQRTDESGTLDTRESTTDRRRMLQGEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1L3</accession>
    <name>A0A183H1L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 72 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1373</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000632">
        <property type="protein sequence ID" value="VDO29297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1L3"/>
    <dbReference type="STRING" id="387005.A0A183H1L3"/>
    <dbReference type="WBParaSite" id="OFLC_0000137201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000137201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000137201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000137201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9611" checksum="80A682CC40BDB938" modified="2016-09-07" version="1">MVQHKMKKKVTLPSGVKQKKKMKSTKQGPKKGHQLTIAPKKPSAVQQAKIDTEITRTINEKNEQLLKSRADKDVGRGYWGITIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1X4</accession>
    <name>A0A183H1X4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1484</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000707">
        <property type="protein sequence ID" value="VDO29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1X4"/>
    <dbReference type="STRING" id="387005.A0A183H1X4"/>
    <dbReference type="WBParaSite" id="OFLC_0000148301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000148301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000148301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF89">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000148301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="63982" checksum="D3F2E98448015CB1" modified="2016-09-07" version="1">MPTNYQKIPTKLSCYQAYSRVIPGPERIHESILIRENELLEYPPDGNVTTMFELLQRAIWLTDNGDFIGEQTKNGTYKWMTYKQVYTASHKIGSALLQLGIDAGEGSRIGIAGLNSARYIIAQNALINYSIVLVPLYHNYNMEFLCAIIDHCKLELIFCDTVERANKFIAEIERKKLKALKKIIIFNDSKEKIDREFSKHSEIQVYNWDYILELGEIHLKPVTPPSPSNIYIICHTSGTTGTPKGVQLSHRAILVSMSGLYVQWCLPPHDIVFDHNDLYLSFLPLAHVYEQLLEAFIIYIGGRIGIFGGDPKRLIHDMRLLRPTIAAFVPRLLNRYHDMVMEKVNKQNIVKRFIFYIALRVHSKLRQLAKGQLQFNTIWDKIAFKKIRTLFGGQLRLITSGGAPISINVMNFSRIVYGCLLIEGYGQTECSAAGTITLPFDTVGGHVGGPAAWAQIKLVDAKELGYSAEENTGEVCFRGAGLMDGYFNDPELTSQRVDQEGWLHTGDIGMWLPNGSLRIIDRRNNLFKLAHADFVSPEQIENVYSQHPLVKQVSLMKNGRKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H215</accession>
    <name>A0A183H215_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1525</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000731">
        <property type="protein sequence ID" value="VDO29861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H215"/>
    <dbReference type="WBParaSite" id="OFLC_0000152401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000152401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000152401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000152401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11483" checksum="E4F87563B817A103" modified="2016-09-07" version="1">MNAEDFTNDKTFCREYKLPTDNIACSLHHPNGTRVGNVTYYSTAGRIKGKSRVLYKTRKNNSDYGPTYHTNNFKWWQEKRVIGQHFQDTMSDAKPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3D0</accession>
    <name>A0A183H3D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1990</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001066">
        <property type="protein sequence ID" value="VDO31504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3D0"/>
    <dbReference type="STRING" id="387005.A0A183H3D0"/>
    <dbReference type="WBParaSite" id="OFLC_0000198901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000198901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000198901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000101">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein tir-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000023">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein tir-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="6">
        <location>
            <begin position="141"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO31504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000198901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39832" checksum="309AE697A110C855" modified="2016-09-07" version="1">MYKFVQIGFESYADAFAKHMVDGDLLLLLTEKELEQDLQMSSALLRKRFIRELESLKIAADYGSVDESQLDQFLMSLSPELSVYTYQMLGMGLNRNLLPSLTDEMMKTVCGMHNPIHRLKLRQALQDSKHIDDIEVAILSKQIDVFISYRRSTGNQLASLIKVLLQLRGYKVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLFNDHNCEDWIHKELRCAFDHHKNVIPIFDQHFDFPADTDLPADIRHITRYNGVRWVHDYQEACMDKVERFIKGELNRTPSIGQQQASVTSSTSNGTQQRKISARWSIAKTTQKCSVTRQQHNEISNNRCMVIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Z9</accession>
    <name>A0A183H3Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2209</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001223">
        <property type="protein sequence ID" value="VDO32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Z9"/>
    <dbReference type="WBParaSite" id="OFLC_0000220801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000220801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000220801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053965">
        <property type="entry name" value="INTS1_R4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22928">
        <property type="entry name" value="INTS1_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 R4" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000220801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16881" checksum="240049309FB09C21" modified="2016-09-07" version="1">MSASLLSRLETAETSCDRIVLLDELRATTVESPDRIAPFIHLIQAAFTDLLRPVRNLAYQCAMNYISSNPSMSIHFMSAYSAALLHKSADISLHALSFLPEFITTSRCISKNLLSAAVMAANRWPSPESIIDLSRAVTACADFRCADIEENGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H401</accession>
    <name>A0A183H401_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS2210</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01001224">
        <property type="protein sequence ID" value="VDO32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H401"/>
    <dbReference type="STRING" id="387005.A0A183H401"/>
    <dbReference type="WBParaSite" id="OFLC_0000221001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000221001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000221001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040022">
        <property type="term" value="P:feminization of hermaphroditic germ-line"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="377"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000221001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="881" mass="99504" checksum="4FD920FCD4642546" modified="2016-09-07" version="1">VSQEYIEKKEKQWQQKREKPRLTVRQQQIKKDNKMWENNRLARSGVVSLTDDDDFLDDESDENRVTLLVQNVVPPFLDGRFIFTKQNKPVVPVKDITSDLAVVAAKGSKVVRIWREKEEQKKAQEKHWDLAGSKLGNLMGVKAIPDETIRDDSGICYRESQQFASHLIESEAVSDFALKKSIKEQREYLPVFAVRQKMLSVIADNSVVIIVGETGSGKTTQLAQYLLEDGYGNFGLIGCTQPRRVAAMSVAKRVAEEMGVELGQECGYAIRFEDCTSENTRIKYMTDGILLRECLSDPDLDQYSAIIMDEAHERSLNTDVLFGLLRDVIAHRADLKLIVTSATMDAEKFANFFGGHTPCFTIPGRTFPVEIFHARTPMEDYVDAAVKQAVRVHLGGTDGDILIFMPGQEDIEVTCGMIKNQLEELDEAPPLTVLPIYSQLPSDLQAKIFQKAPGGIRKCIVATNIAETSLTVDGILFVIDPGYCKLKVFNPRIGMDALQVFPISQASANQRSGRAGRTGPGQCFRLYTERQFKEEMMIATVPEIQRTNLANVILLLKSLGVDDLLKFHFMDAPPQDNMLNSMYQLWTLGALDNIGRLTDLGRKMVEFPLDPTLSKMLIVSEGMRCSDEVLTVVSMLSVPAIFFRPKGREDDADAKKEKFQVPESDHLTFLNVYLQWRLHKYSTKWCNDNFIHIKAMKKVREVRAQLKDIMEEQKIELISCGTDWDVIRKCICSAYFHNAARLKGIGEYVNVRTGIPCFLHPTSALFGMGYMPDYVVYHELIMTAKEYMQCVTSVETSWLAELGPMFYSLKEAGSSRIEKRLQSIQDARDMEEEMKQATSRLNEIKKAEKEESYSTRSISSVQIAEPGKVCASVRSSARFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H422</accession>
    <name>A0A183H422_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2232</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001241">
        <property type="protein sequence ID" value="VDO32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H422"/>
    <dbReference type="STRING" id="387005.A0A183H422"/>
    <dbReference type="WBParaSite" id="OFLC_0000223101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000223101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000223101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000223101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21219" checksum="AC0A7DC8304B4CAD" modified="2016-09-07" version="1">MQLYNVEIKFFHRFQISGELFTLTYGALVAELLRDLESPLAVNRQLDKMGYNIGLRLADDLLAKNSQIQRCTDMHQVADVLAKVALRSYLGENVLESVTAQVSNWNARNDEFSLVLESNPLAEFVEVPSELAQDLRYSQILCGAIRGALEMMHMEVQTFIVQEQSQSVEIRVKFIRILQESVPPGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H503</accession>
    <name>A0A183H503_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2563</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001498">
        <property type="protein sequence ID" value="VDO33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H503"/>
    <dbReference type="STRING" id="387005.A0A183H503"/>
    <dbReference type="WBParaSite" id="OFLC_0000256201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000256201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000256201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000256201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38404" checksum="01EEA51124D5264D" modified="2016-09-07" version="1">MNTENRRSDGSAIIPPALLARPSVRRGSVFSDLLTVFRRHNSHSNRLFRQLSHSSTSKLKKKKKQEGETSLSPTTCTNDQSQEEESDENGKPMSRQVLLDKIREKKEVIGTLRCQPWNMNRKRRTLRLAQKYVAQHELRVSKTNLLKVTLKKKWCAFCRWADNVKIYLIPWESKIKRIESHFGSVVSSYFTFLRWIVYVNLMITLIIVSFIVIPEMLADAAADPSRVNRTASRKIIPPRELKHADELQVVSNFDVLSYLFFYLPLVLRIDARPFESFSFAEGYLKYSPLFYGYYSNDEFVGGRIRYAVPLAYFLITLFVFGYSCFAILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H515</accession>
    <name>A0A183H515_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2575</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001507">
        <property type="protein sequence ID" value="VDO33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H515"/>
    <dbReference type="STRING" id="387005.A0A183H515"/>
    <dbReference type="WBParaSite" id="OFLC_0000257401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000257401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000257401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552382" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000257401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13308" checksum="D0BE9792B9DEA695" modified="2016-09-07" version="1">MTTIYLFVGTLLLPALLVCNVPMDRAERLDRDLEQFTSAINGALRLRYGKRSYDSDMIGKTVRSQEQKQLPLTDRVIASLNGAERLRYANHFGENLNYKTFSQKTFCIICKRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5P9</accession>
    <name>A0A183H5P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spectrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2809</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001713">
        <property type="protein sequence ID" value="VDO34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5P9"/>
    <dbReference type="STRING" id="387005.A0A183H5P9"/>
    <dbReference type="WBParaSite" id="OFLC_0000280801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000280801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000280801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21194">
        <property type="entry name" value="CH_beta_spectrin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000089">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000280801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="634" mass="73519" checksum="372E77F4CAB3C23D" modified="2016-09-07" version="1">MKLIVLLESCNDIGSDDDYFQARLEIVDLFVDFGDGVLLMKLLEIISGEKLGKPNRGRMRVQKIENLNKTLDFLKKKRIQLENIGAEDILDRNERLILGLIWTIILRFQIDTISIPMDEESGERKHAKDALLLWCQRKTAGYANSKVENFTTSWRNGLAFNALIHAHRPDLINYESLLPQDAIGNLNNAFDVAEKKLDIARLLDAEDVNVTHPDEKSIITYVSLYYHHFAKQKTEMTGARRVAKIVGSLMSSDQLQEDYEALCSELLLWIQQTIAMLNDRRFPNSLKGIQDELLEFKNYRTMEKPPKYKEKGELEALFFTIQTKRKAMGRKPFVPATGLFMHDIESAWALLDHSENDRQLALMMELRRQERLELMAQKFERKAGLRDAWLREMSSVLQDFDLGRNIAQVEASMKKQQAIAADILPRIASFQENRFKSLSFMAAELSKENYHDSDKIRIRERELLDKWSQLLAALEARRRALLSLSDLMGLLRDIDTLSSEIRALEPQFRSRDVGKHLLGVEDLLGKQEILEAQLNSQGELLKNVTLQALDYIRGKGEQYDVLQRKLDDVSSLYESVVQLCQQRRMVLYRARDLYRFIQDDEEEMSWLQEKEDLCIALLKNRDLSATAQLRRIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5X7</accession>
    <name>A0A183H5X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAM91_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2888</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001783">
        <property type="protein sequence ID" value="VDO34563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5X7"/>
    <dbReference type="STRING" id="387005.A0A183H5X7"/>
    <dbReference type="WBParaSite" id="OFLC_0000288701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000288701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000288701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 C-terminal" evidence="2">
        <location>
            <begin position="76"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000288701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54663" checksum="D115FCA7CC25ADCB" modified="2016-09-07" version="1">IQYSFLTFNRVDEDSTAAITADLSDFSTALVSPGGADEDDENESGADGLIINQEVLIASCTSLSLAPTPSSGNEAAKRIAFLFDSSLTAFLMMGNLSVSLKNHAVTLFEVGKLSDESLDSFVEELQNVKLFMEGEAQRYSEHAQTLLLTIISLRSSSELDLIRGESLLSLDQPTRLRLINKTYRCLVSMAPLSGEACPLSVPSIPHLGTIIPEVVSSWFRLFLYCTLGDGPVSLFIPKGSRFPIIPCALRRCKHLLITTASHEPVIVSVDNCLIQLNDMLQMHAIFVQEYSAVTDDSEIVSVPFPFTDSSLINGHFSSHPSILKLREKLGLNSLCGYLTLLCRKKSAKWEEQSQKNRKSNSTTVSKDPRKIANLRVHLRDDETYADYTVLDCIFGVPLFDEHLNKIICQRIKDCRLLDPKKCLFSYASLNMVEFANHDLVHSLRELINKYQTWGEEPISVWEMSRWCPPTQILLFQNGEINIVDDLRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7E0</accession>
    <name>A0A183H7E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3402</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002261">
        <property type="protein sequence ID" value="VDO36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7E0"/>
    <dbReference type="STRING" id="387005.A0A183H7E0"/>
    <dbReference type="WBParaSite" id="OFLC_0000340101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000340101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000340101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="13"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000340101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43327" checksum="7319941FC4AA0C35" modified="2016-09-07" version="1">MNQFSALNKFMLQVVVTFIAWYFVSSASSIVNKITLQNYPYPMTVALVSLCFVELCSVPVLRLWRIKQPSISVHYLIYYIIPISLGKVVAVVCAYVSVWKISVSYVQTVKATMPLFAVFSARIILKEHQTKPVYLSLIPIIIGVAIATFTELSFDLGGLFSALLSTGIYSVLNVFVKKVLQGTDIHPLYLLSLNSRIAAILLFPVWCCRDGLLLWRGVESAKNQPSPHEPNFVIFLMLSGILSFLQNLCAFILIHRLSALSYAVANATKRITVISVSLLTLHNPVTPANVFGMFLSIFGVFLYNRAKQFEKEYRTLPKSQTDLTKSDTSSVSLHASAIYNEKLTSELPSFNFIEIICCCPKMVLRWAVVAIFITILICLFAGHPDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7N9</accession>
    <name>A0A183H7N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3501</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002351">
        <property type="protein sequence ID" value="VDO36738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7N9"/>
    <dbReference type="STRING" id="387005.A0A183H7N9"/>
    <dbReference type="WBParaSite" id="OFLC_0000350001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000350001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000350001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552412" evidence="3">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="4">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000350001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27308" checksum="DFF5646AD083303B" modified="2016-09-07" version="1">MFIRSEYFHIFILPLFTATAIIAPPTCEDIITTSNGNVIYMEANYEAKHSPGTAALMACKFGYVSSLPYLVFCQANGTWNYKLGECILTSKTCSPQNTESNVVYMPPEISDIYPSGTFAMLHCSIGQLPIGPSSAVCLNGEWNVELGYCKELHSDGIFSGPSQRRDISITDFKTGSETINAEDKSITFAMLTETENATLPANISEAIFDEWSITLNETVEDTAPLDLIKMEKLSDESFAITISSILPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8W6</accession>
    <name>A0A183H8W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA_int_end_N2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002796">
        <property type="protein sequence ID" value="VDO38250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8W6"/>
    <dbReference type="STRING" id="387005.A0A183H8W6"/>
    <dbReference type="WBParaSite" id="OFLC_0000392701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000392701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000392701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000392701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37855" checksum="6EF7A75AD5E6E5AD" modified="2016-09-07" version="1">MEYKARPNTMNSHLKYASNSARNSQKLTLIEYNAKENVFKALQLRNACEMKMGIRRRNGHYFFVEEVVWMVETGLAVVLHRGRQLSVQECYRLLGTFLITPEKFFVYSYLKRAGYVIVPYKAFGISVDDENDKRWEHEPKSLFPVSLLDQFPTIQSMKLRMTNFRQNPKLVEVFGIADDFPTSNIESVNWNRYNEGRRNFKEFLRPHYWPRFDQFSSCVPTWSDYRKERAKILKLNPAENITDSFHLPIDYDIYVGDNTFCRNLSPKPIYHLLIVDIRFPFPSVSDLHWLSSKIPDGRLLIAVVQQAAVIFYNIDHQPVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Y8</accession>
    <name>A0A183H9Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RunxI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4299</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003204">
        <property type="protein sequence ID" value="VDO39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Y8"/>
    <dbReference type="STRING" id="387005.A0A183H9Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0000429901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000429901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000429901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000429901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8393" checksum="C69ADAEBAFB7B5F6" modified="2016-09-07" version="1">MYPLPQPTMDPYSFANAGLGMGASQHPSDFSSYHMFSSTGRSPYDAFHPYARTVQPGAPPTFASTMNHSSISNVGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW4</accession>
    <name>A0A183HAW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003605">
        <property type="protein sequence ID" value="VDO40544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW4"/>
    <dbReference type="WBParaSite" id="OFLC_0000462501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9056" checksum="4AB5296AAD69E1BC" modified="2016-09-07" version="1">MVSNSSDGRNGSPATSRNRIPWHRGLLKSCCYWNAVLAIGELQNVQIGSGRGRRHPTVHLLLCMRKCVHLFVVPSVVNCTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB38</accession>
    <name>A0A183HB38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4700</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003696">
        <property type="protein sequence ID" value="VDO40778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB38"/>
    <dbReference type="STRING" id="387005.A0A183HB38"/>
    <dbReference type="WBParaSite" id="OFLC_0000469901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000469901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000469901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000169">
        <property type="entry name" value="DNA-binding protein SATB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO40778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000469901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="10041" checksum="26C3C9E2CC3FB633" modified="2016-09-07" version="1">MAALERDPYITRFNHLLEIPKLERWFRTDPNPSRQKLINYMNVLNGSSYRRHNVKVTYQQICNWFANQRAANRFCVLLPKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB46</accession>
    <name>A0A183HB46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4709</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003709">
        <property type="protein sequence ID" value="VDO40812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB46"/>
    <dbReference type="STRING" id="387005.A0A183HB46"/>
    <dbReference type="WBParaSite" id="OFLC_0000470701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000470701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000470701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF1">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552456" evidence="1">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000470701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26835" checksum="39D3331724A47551" modified="2016-09-07" version="1">MRLLWLFLFVEQVHSGFTPCNGKSLLGGTCDWNIDCENKGSICLRGRCRCHPHYVEVVDEKRQNPRCKRLPAKVGQRCTSKCREPLFCRSGQCQCVQRGTTTLVNGQCVSMSRVGDRCTRHYDCTAPFSACLNSQCVCISGTIQQGSQCIAKPACPLGGNPGNACIRKANPHIVENFGDEIDDCPLGQICITIGESPMGHCCPKVCPLGTLPEYNYSCDPTARIRCPSDTHFCHRISGTFSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB76</accession>
    <name>A0A183HB76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4737</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003749">
        <property type="protein sequence ID" value="VDO40903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB76"/>
    <dbReference type="WBParaSite" id="OFLC_0000473701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000473701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000473701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000473701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10022" checksum="1E9E112FB7442D0E" modified="2016-09-07" version="1">MARIVDPEKMRELENHQEMLKKIEQLSIKRQTILNAFNGDAKAYLANHQAKMKQMAQLEEEIKNQEKVIAALDDRILEIDSMLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB92</accession>
    <name>A0A183HB92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4756</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003775">
        <property type="protein sequence ID" value="VDO40953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB92"/>
    <dbReference type="STRING" id="387005.A0A183HB92"/>
    <dbReference type="WBParaSite" id="OFLC_0000475301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000475301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000475301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000475301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8047" checksum="9982C57197C9BC39" modified="2016-09-07" version="1">MQWSIFIETINVSSNHTATDNVNHRERSCGWRSLNDYERPSSVADVTWLSRSRSEVTSRERITLFRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBH2</accession>
    <name>A0A183HBH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4832</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003870">
        <property type="protein sequence ID" value="VDO41193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBH2"/>
    <dbReference type="STRING" id="387005.A0A183HBH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000483301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000483301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000483301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF467">
        <property type="entry name" value="LATROPHILIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000483301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30335" checksum="317070598E628FAF" modified="2016-09-07" version="1">MLLEGFELYYMLVEVFQSKDSKRFYLLLFGYGFPLSVVVLSVWFDRFSYGTERYCWLRSDNYFILAFVGPVAIILLCNTIFLAMTLFIVCSHSSIGYTPCKQDRDALKNIRNWLKGSIALVTLLGLTWTFGLLWIDEQSIIMAYAFTIMNSLQGLFIFLFHVVFNDRLHKDYRKWVKHSFWAPNCIRDDSSHTSRTMPYLPTSNVSKAGQAVSSSSSTASELLRFTKHLGGKSDEYSPLLATQRAGLTDEQIHVRRGNFKNIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC27</accession>
    <name>A0A183HC27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5038</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004132">
        <property type="protein sequence ID" value="VDO41848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC27"/>
    <dbReference type="WBParaSite" id="OFLC_0000503801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000503801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000503801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000503801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5197" checksum="BB4E9FBDAF6392B7" modified="2016-09-07" version="1">MHLCQKPVMTTKAAEKKVVTTKALKPVVERGHSIIICLNNSFFAIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC43</accession>
    <name>A0A183HC43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5057</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004155">
        <property type="protein sequence ID" value="VDO41917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC43"/>
    <dbReference type="STRING" id="387005.A0A183HC43"/>
    <dbReference type="WBParaSite" id="OFLC_0000505401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000505401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000505401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000505401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15887" checksum="CD955C94259C8600" modified="2016-09-07" version="1">MNDFIRISIFGKTIHSAVGIAPSLIYLCNESILFGKFLQVMLIGDSCCGKTCLLIRFKDNTFLNNNFISTVGIDYRNKLVEVDNTKVKLQIWDTAGQERFLSITTTYYRGADALLLVYDLTNRQSFINIRVSLRNACKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCP8</accession>
    <name>A0A183HCP8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5261</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides.</text>
    </comment>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004431">
        <property type="protein sequence ID" value="VDO42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCP8"/>
    <dbReference type="STRING" id="387005.A0A183HCP8"/>
    <dbReference type="WBParaSite" id="OFLC_0000525901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000525901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000525901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000525901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12483" checksum="AD03F9383D4704EF" modified="2016-09-07" version="1">MLSEFCSECGTVLPIPATAPITVTCNYCRTQWHIKPIINKLVYRSEKIYQKRVMDAKEGTLENPVVDKICDKCGHDKMSYACRQTRSADEGQTVFYMCLKCNYNMVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD16</accession>
    <name>A0A183HD16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CPSF73-100_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5377</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004584">
        <property type="protein sequence ID" value="VDO42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD16"/>
    <dbReference type="STRING" id="387005.A0A183HD16"/>
    <dbReference type="WBParaSite" id="OFLC_0000537701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000537701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000537701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="4">
        <location>
            <begin position="8"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000537701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24552" checksum="B251FF65C5132B0A" modified="2016-09-07" version="1">MAMSPPKDGQILSGVLIRRNFNYHLMHADDLSAYTDLSSSILTQRESVFYNGTITLLLHNLQQVAGDVSFDEIDSKDTSDPTHSIKLFDGRIHVLVYYSQHVAIIEWTSNPVSDMFADATLAAILHAQTNPVPDKNLGKWNVKPNEIECLMKTLSELCGDEAIIQNTGNTIDLKVDGKEAKIDLDTMHITCTDQLLHHLISSVCQKMMNSLLPVCTLTIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD42</accession>
    <name>A0A183HD42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004627">
        <property type="protein sequence ID" value="VDO43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD42"/>
    <dbReference type="STRING" id="387005.A0A183HD42"/>
    <dbReference type="WBParaSite" id="OFLC_0000540301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000540301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000540301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF6">
        <property type="entry name" value="PROTEIN CBG19234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000540301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13993" checksum="43F631F9ABBAF582" modified="2016-09-07" version="1">MNTEVYLIFRTSLQRLHDSGVFNSMALIIMGDHGNRIGSIQRTYIGRIEERAPLFSIKLPDAFTFKYEREIKNLKKNTKRLTSNFDIHQTLKDISKAEFRRNRSYYDQKGNFKETKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEM2</accession>
    <name>A0A183HEM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5934</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005376">
        <property type="protein sequence ID" value="VDO44854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000593301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000593301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000593301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000593301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9193" checksum="2D3432DBC37B816D" modified="2016-09-07" version="1">MCWGKIHQSLQNFFQFFERNCNTMNTWNAMTSSDRSFEGQTMMEQVCTQEELIGRNASQEQTSIIYYVHAYANTLTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEU1</accession>
    <name>A0A183HEU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A20-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005469">
        <property type="protein sequence ID" value="VDO45092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEU1"/>
    <dbReference type="WBParaSite" id="OFLC_0000600201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000600201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000600201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000600201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20168" checksum="1E624F95B40AE1C5" modified="2016-09-07" version="1">MHIFRPKKPVLVGVAEDGGIDTTDSGSMIHDEEKKETEKMSVSQVLSVAPVASAELGEAQPTIVSHDEINTGDTSTEPEGYEAFILSLIQSILFQLSKTDQILKRIFIHYPYFTLIMYRLRWQLQLGERISFACSAGARKNDFCSRCWRDIRVPLQYEAAHRLAAMEQDDSNVRMSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFC4</accession>
    <name>A0A183HFC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6186</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005741">
        <property type="protein sequence ID" value="VDO45708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFC4"/>
    <dbReference type="STRING" id="387005.A0A183HFC4"/>
    <dbReference type="WBParaSite" id="OFLC_0000618501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000618501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000618501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000618501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38102" checksum="DF46DE2EDA40B179" modified="2016-09-07" version="1">MSESRASSASPPTILRITSDLPLDDPKSVPTTETKLIKISNSLQNPESSLAINENLCSKSDDATPGSILKKESVEKVGFLEDQKSSDVDAQKSAEKVRNANENEVHLTAFHQTSIEKSDEVGNEGAEKTVISESFKTDEPTDRVTARTVDDAGAEKDNNEVWMTPENTPVMPNIEIKTENDGEVCAKNSESTEEGRQTSLRNTADERHIQGNFQGANTNISNEKLSVLSDKNFEDDHKLRKIDNTERMTRSENLDFTNDHLESYASLEFRSNSTVSKSPDHRSTGTVSESPPGATDSWKNATINMNPSHDDGTQGGIQSAYNTTSRNDQTKIIYNNTTLSELILMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG42</accession>
    <name>A0A183HG42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006142">
        <property type="protein sequence ID" value="VDO46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG42"/>
    <dbReference type="STRING" id="387005.A0A183HG42"/>
    <dbReference type="WBParaSite" id="OFLC_0000645301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000645301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000645301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000645301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14545" checksum="C97B19144B0453A8" modified="2016-09-07" version="1">MFLLHNSSSIPNQINSVSHFTNVKNSPIRIIVLCKSNRLTILQIKINPVAPQAAVAVFSFTATLFLLTAPETKDRPMPEDLDQFDPGCFLQMFDYRMQKKRGVLITAKDIEETSIGYLLYFFFFIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG68</accession>
    <name>A0A183HG68_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6479</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01006175">
        <property type="protein sequence ID" value="VDO46672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG68"/>
    <dbReference type="STRING" id="387005.A0A183HG68"/>
    <dbReference type="WBParaSite" id="OFLC_0000647901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000647901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000647901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552519" description="palmitoyl-protein hydrolase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO46672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000647901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20350" checksum="CCD310359B40C4E6" modified="2016-09-07" version="1">MQGGTRRTSSFFTNRILLGLFNCCLPGSCSSKAKLRTEMAEPVIIPPRGKHTATIIFLHGLGDTGHGWSSVFADEIRHDHIKYICPHAPTRAVTLNFGMQMPAWYDLYGLTPNTEEDEEGINESAMILHSLIDAEISAGIPSERIMVGGFSMGGALALYAGLIYDKPLAGIIGLSSFLVQRTKLPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGK5</accession>
    <name>A0A183HGK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6617</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006399">
        <property type="protein sequence ID" value="VDO47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGK5"/>
    <dbReference type="STRING" id="387005.A0A183HGK5"/>
    <dbReference type="WBParaSite" id="OFLC_0000661601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000661601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000661601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="122"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000661601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31023" checksum="4D8AC84A3E7D255B" modified="2016-09-07" version="1">DCIELSEEESILSDVLTRKQSDTNNKVAIVEEAEEKKQDGSEQSKLIENSKLSDQESEVAKAKLSTAKKPEVNKAFELQQASDRIMTASIFDVNSKVTRQAPELPSIDGIEYPRAASWASESLNNVLKDEKGRQLFRVFLHDSLAEENLSFIESFEKFKRMTSAIEKKRYIQEFFDKYSPYVNLSSVALQKIKTAATQDDPDPSAFLLAIKEVNRMLENDQFPRFKRSDIYINFLEKVMPRAYADKWATSFEALVGNQAIFSILFFSTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHZ3</accession>
    <name>A0A183HHZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PheRS_DBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7105</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007182">
        <property type="protein sequence ID" value="VDO49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHZ3"/>
    <dbReference type="STRING" id="387005.A0A183HHZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000710401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000710401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000710401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PheRS DNA binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000710401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22028" checksum="DD1DA9888DC2FCDE" modified="2016-09-07" version="1">MEKWNPQVLNDHLANFSYIGEYSPCDSDWTIYRKFASEIINPIKYPHFHRWLNHLKFLERTTLDLSLFFCALNSLSDTSEASLLNGVYETRMPPSGIEDAGDASLSQNLLHHLEKYHHFDTFEYAASTGEDHQKVVGAVKSLEALEKLVETEERVSKTLELTVEGNEMVANGSHEAKVFSFIGRNGIDQMELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIL1</accession>
    <name>A0A183HIL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FtsZ_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7323</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007556">
        <property type="protein sequence ID" value="VDO50400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIL1"/>
    <dbReference type="STRING" id="387005.A0A183HIL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000732201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000732201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000732201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000732201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16082" checksum="61F08EAF2B379B44" modified="2016-09-07" version="1">MKCRQIFNEDPILVQDKNVVKITEKEKELILNEITNIGKSIVCVEPVFKPVVVNMDTCSNLAEVGIYLCDIYDRIESFSSFSKQAIVICGTNVLDEFEDVHDVSNDLMDCVNVIQDLIDKIVSIEVIQSASNIEDVDIRAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIQ1</accession>
    <name>A0A183HIQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007639">
        <property type="protein sequence ID" value="VDO50629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIQ1"/>
    <dbReference type="STRING" id="387005.A0A183HIQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000736201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000736201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000736201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000736201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9407" checksum="F9D27EEAB9C0E528" modified="2016-09-07" version="1">MGSQSSALRWNANTSSRIEDLDFYIGDEALSPSAANYAVKYPIRHGIVEDWDLMERFWEQCIFKYLRAEPEDHYFLLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIW1</accession>
    <name>A0A183HIW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS7424</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007750">
        <property type="protein sequence ID" value="VDO50947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIW1"/>
    <dbReference type="STRING" id="387005.A0A183HIW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000742201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000742201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000742201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="3"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO50947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000742201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30668" checksum="420DDCB867383421" modified="2016-09-07" version="1">MLVTTALLGCAFLNSIRVVSNLSLINAISHMIINAIIFIYCLLQAIPFTFDIRTMPTVIGVVVFGYTSHIFLPSLEASMEDPSKFEWMLRWSHIIAAIFKALFGLLGFLTFGEFTQKEISSSLPNQAFKVIVNLVLVVKALFSYPLPYFAAVHLLKDNLFLGTPKTLFTSCYGAGNSLREWALCLRIILVLITLMMAMSVPYLIEVMGLVGNITGTMLSFIWPAMFHLKLKGAYGKESDRKFDKFIIGVGICLMTIGLYFSTVELIQAVKYEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT2</accession>
    <name>A0A183HJT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fam20C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS7746</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008281">
        <property type="protein sequence ID" value="VDO52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT2"/>
    <dbReference type="STRING" id="387005.A0A183HJT2"/>
    <dbReference type="WBParaSite" id="OFLC_0000774301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000774301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000774301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000774301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27739" checksum="EB1CDA4F425640DA" modified="2016-09-07" version="1">IYNSRFGRDYESNPNHFYFSDFERHNAEIATFHMDKILGFRRAVPTVGRIVNLTSDLRNKAEKRLAKTFFFSPAKNLCFVSKCDYYCDTSHAICGTPDTREGSVQVFLPDENSVPRKHNKSPYRRTYSKKNQIAEWQRNMDYCRESVKTTKRYAHGRTLLDLVDFHIMDYLIGNQDRHHYESFSIFTNVPSYAIHLDNGRAFGRTDFDDDDILLPLRQCCVLRSSTFFTLLKYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJW5</accession>
    <name>A0A183HJW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">REPA_OB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7778</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008342">
        <property type="protein sequence ID" value="VDO52478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJW5"/>
    <dbReference type="STRING" id="387005.A0A183HJW5"/>
    <dbReference type="WBParaSite" id="OFLC_0000777601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000777601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000777601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000777601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15569" checksum="8AA65049DBCD18F9" modified="2016-09-07" version="1">MATYIGKVGIVKDVTMESIQVTIFSWGTSEGAMTITSNNSNQARRNQPEIGRNTVVEATYSWHPKTVLLAQNVCLLDGDRAIMIRNKDLSKATMVSIRVLDDETFVLRLPHAESFVWKQSENMNDIILPIYSGNKFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKJ9</accession>
    <name>A0A183HKJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008748">
        <property type="protein sequence ID" value="VDO53624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKJ9"/>
    <dbReference type="STRING" id="387005.A0A183HKJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000801001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000801001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000801001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000801001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6982" checksum="5EFF66060F26F2F7" modified="2016-09-07" version="1">MKSQVWLYVNRYSENRHTGLMQKEQNTQASSSIIRVHETSAEPVTKKPRKEVKSEFSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKN9</accession>
    <name>A0A183HKN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CNOT1_HEAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8051</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008825">
        <property type="protein sequence ID" value="VDO53806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKN9"/>
    <dbReference type="STRING" id="387005.A0A183HKN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000805001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000805001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000805001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="2">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO53806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000805001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20371" checksum="7BF49E33E0E8C6FE" modified="2016-09-07" version="1">MQHSKLTGQNRAFVLSTVNRVLEHNQTPQDLDEQQALLIINLATQEMTLSKENDDWPQAACNVLVTLAKRSRFVGHVMEALLQKFPPGQISSPHRYIILTLANVAEHNAVGFVPFLTDILSRAISVLPHIKTDFYRYAWAHALRAFCESVREYVSASAMTKTENDKNGSGDNHIEDEQVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL24</accession>
    <name>A0A183HL24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8189</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009062">
        <property type="protein sequence ID" value="VDO54461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL24"/>
    <dbReference type="STRING" id="387005.A0A183HL24"/>
    <dbReference type="WBParaSite" id="OFLC_0000818501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000818501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000818501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000818501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11310" checksum="7775973E85A272B3" modified="2016-09-07" version="1">MSAVCAFRMETIKRIFDYGHFKIQKTAQSLWMPYRPHENMPIPRPGSCVTDSSKLSENIVSFIARNPLMHEAVPAVRSRPILVQGPERAPFTQIAVSPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL58</accession>
    <name>A0A183HL58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8217</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009121">
        <property type="protein sequence ID" value="VDO54613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL58"/>
    <dbReference type="STRING" id="387005.A0A183HL58"/>
    <dbReference type="WBParaSite" id="OFLC_0000821901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000821901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000821901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Talin 1-like rod-segment" evidence="3">
        <location>
            <begin position="34"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000821901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19033" checksum="802C072E6102F457" modified="2016-09-07" version="1">MEIKRILDDLSRGSQTVVERVQEVLAALHEGSRGTQACINAANTVSGIIGDLDTTIMFATAGSLNPQRDSEKFGDHREAILKTAKALVEDTKALVAGAASNQEQLAVAAQNAVRTIVNLSDAVKNGAVSLSSDNAEAQVMVIHAVRDVAAALSNLIQATKNASGRSLHDPAMGHLKEAAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLH2</accession>
    <name>A0A183HLH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8335</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009321">
        <property type="protein sequence ID" value="VDO55134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLH2"/>
    <dbReference type="STRING" id="387005.A0A183HLH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000833301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000833301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000833301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000833301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12718" checksum="AED13E46B060CB5A" modified="2016-09-07" version="1">MLFVLSSYACFFQRNIVRALSTFVAVIDETDSHFSYENLEKLLQSVGQRWMSVCEWAEMRARQLDGLSELIARYTSAYRKILEWLDNWEAVSLKESISFFRYTYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMR0</accession>
    <name>A0A183HMR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8772</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010198">
        <property type="protein sequence ID" value="VDO57321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMR0"/>
    <dbReference type="STRING" id="387005.A0A183HMR0"/>
    <dbReference type="WBParaSite" id="OFLC_0000877101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000877101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000877101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033294">
        <property type="entry name" value="Erlin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351:SF3">
        <property type="entry name" value="ERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351">
        <property type="entry name" value="ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552578" evidence="4">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO57321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000877101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22882" checksum="3A47CD25CC652571" modified="2016-09-07" version="1">MIGQFLINLVILLSIRAINSLFTDQIDENLKTALQKDLVKMAPGLSVQAVRVTKPKIPESIRQNYEQMEAEKTKLLVAIQHQKVVEKEAETERKKAVIEAEKAAQVAAIHYEQHIAEKEAQKRISQLEDESHIARATARADAEFYSRKKQAEGNQMLLTKEFLELKRIEAIAMNNKIYYGSQIPNAFLDIELPSVQKQSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPE3</accession>
    <name>A0A183HPE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WS_DGAT_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9355</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011388">
        <property type="protein sequence ID" value="VDO59979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000935401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000935401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000935401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000935401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19541" checksum="1FAADFD4EE5D3E69" modified="2016-09-07" version="1">MLSWKIHFRCLFWYGLLSLSLSYSIYNFIIHEADSGTLLEFIRLSDSPIYSDIMNTTSPAIVILLTNKLSQNYDELKSLIPAEVKYLNDRRDAFKVKTPQVHVLIRPTHSAVLPGFIKFMSPIRKMNSSDIAKFVMLSMEIEKSIISPNIHKVLCFPDQQMILMNTVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ20</accession>
    <name>A0A183HQ20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase_M16_M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9580</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011897">
        <property type="protein sequence ID" value="VDO61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ20"/>
    <dbReference type="STRING" id="387005.A0A183HQ20"/>
    <dbReference type="WBParaSite" id="OFLC_0000958101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000958101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000958101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="3">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000958101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18496" checksum="58FF047BE94DB5D7" modified="2016-09-07" version="1">MFFWESNEERYNILKETFCRNLRNFRQGQPYVQSHYYTMLILGSRQWSKEEILACAEKTEVERLRRFTRDSLQALQIEMLVCGNSTEKESTDILDDVVSKFKGLPDTRHLFDIELDQYREHEIPKGKIFIIRLNFAFVMLVLVLQWEHIFHVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ68</accession>
    <name>A0A183HQ68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012027">
        <property type="protein sequence ID" value="VDO62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ68"/>
    <dbReference type="WBParaSite" id="OFLC_0000962901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000962901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000962901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000962901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4513" checksum="BAFCDB325CE8F75C" modified="2016-09-07" version="1">MDSDVLKLKEAVIDKLRQNGTLDRIQVCRVYFLKMPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRR3</accession>
    <name>A0A183HRR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013294">
        <property type="protein sequence ID" value="VDO66434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRR3"/>
    <dbReference type="WBParaSite" id="OFLC_0001017401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001017401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001017401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001017401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19918" checksum="A570030E5BF325DE" modified="2016-09-07" version="1">MVRRGKLERIVSWKYVRYFELYDDTTVNEIISIASVDMLKSLLYSSWHDLHASKKFTFYFALAKHQNEDKRKLLSIVLKDILEVIVDIAGTNYLIVAGFLQHILPIVTGNAYERDFISFALALLAANYESLSSDSIALRNAVSLLLVNNILLKFSCLFSLDVVTSVALSLPSRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS51</accession>
    <name>A0A183HS51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013603">
        <property type="protein sequence ID" value="VDO67513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS51"/>
    <dbReference type="WBParaSite" id="OFLC_0001031201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001031201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001031201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001031201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="4120" checksum="3FEC21560D70CC84" modified="2016-09-07" version="1">MLEMKEEGSHLMETLKLSRRSRTIMYHRFHQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSB2</accession>
    <name>A0A183HSB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic FMR1-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013758">
        <property type="protein sequence ID" value="VDO67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSB2"/>
    <dbReference type="STRING" id="387005.A0A183HSB2"/>
    <dbReference type="WBParaSite" id="OFLC_0001037301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001037301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001037301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001037301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23273" checksum="7EEBCC40AE4A7344" modified="2016-09-07" version="1">MQIQPFSFVKRSPYFEPSKWPNANNEGEKCHVNITEKLKTMREQHLEYVTNLSRLNNEVAVYDRDGPRSDSENREMTQLMLDGIQFLCSWTSDVVETISWKLLHPTDHRTNSACPETAEEYERATKYNYQPAEKAALIETISMIKSVQHMLSKMEPILSVAIRKHIYAEMQDFVQITLKEPLHKALKNKKDLLAGQVIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSN5</accession>
    <name>A0A183HSN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKS_AT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10495</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014046">
        <property type="protein sequence ID" value="VDO68937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSN5"/>
    <dbReference type="STRING" id="387005.A0A183HSN5"/>
    <dbReference type="WBParaSite" id="OFLC_0001049601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001049601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001049601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="2">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO68937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001049601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49962" checksum="091A588BD03BFDF7" modified="2016-09-07" version="1">KIPEDIEISAILRSDLKCLIGKPEIIDELKKKLEKNEIHHRELATNYGFHCSFMDSILEEFAQFLKNFTFRKPTKQILSNIDGQLITHFDSKYMVKHMRSAIRIDKCIENLHNRNIKVIVEIGPKGIVESLLKDNSSYEIDVISTLPSKKQHEKGYDTGNLLAIATKLWMKGYNELNWEKICGNYGFDRFLPNYQFEKDICWDNQIQKANIEKPEISLYEPCWIPCKFSTLRRLSKGVLLFLPVISTKSINALLTMLHNLFIPVRCIFNDNLSSKKNLNIINDNIYINSSKEESYQQLADYLRSINFHYDTIIHAWNLSANDEIDRIDNSPHLFSSFYSIYWILANVTQNMIDLRFLACIDWNSEPELFTILGPIRELAMTRQLTKAACILCTSEVNLFEALQLLESSQANFALIRNSMNNEFEHFSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT62</accession>
    <name>A0A183HT62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10673</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014467">
        <property type="protein sequence ID" value="VDO70408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT62"/>
    <dbReference type="STRING" id="387005.A0A183HT62"/>
    <dbReference type="WBParaSite" id="OFLC_0001067401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001067401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001067401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO70408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001067401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14124" checksum="9D56191F958B03E5" modified="2016-09-07" version="1">MLQPAPEITSVRNESVARGSSAFLHCRTQNFHADIQWLRNDAVIGNTAKTRLFPNGTLMISDVNMQDAGIYHCRVQTSGGRAEAAMYLRVLEVPKVQVTPKQLYFVHGQSFNVSCSVDGKYSSEFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTJ2</accession>
    <name>A0A183HTJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1681 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10803</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NECAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014833">
        <property type="protein sequence ID" value="VDO71439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTJ2"/>
    <dbReference type="STRING" id="387005.A0A183HTJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0001080401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001080401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001080401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO71439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001080401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16775" checksum="923F7C0883018879" modified="2016-09-07" version="1">MRLVTIGNKLELRLEDKVSGQLFAKCPVDEYPGLSIEPVLDSSRYFVVRLKNDNGQTAFIGLGFADRSDSFDLNVALQEHFKYIEKSAEFSKEQMNDQPKLDLSFKKGQTITINFGKKTSTNPQQTRTSPSDASSNSGAFPLLPPPPSAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUG8</accession>
    <name>A0A183HUG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pkinase_Tyr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015669">
        <property type="protein sequence ID" value="VDO74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUG8"/>
    <dbReference type="STRING" id="387005.A0A183HUG8"/>
    <dbReference type="WBParaSite" id="OFLC_0001113001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001113001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001113001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001113001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10992" checksum="266672FA003FBBE8" modified="2016-09-07" version="1">MYGCCTEPNHQCMIMEYVPFGDLKHYLQNLRKQFDRAMVNMKSSFYGRDAPISPSLPPSMHSSFLSNMDDNSPHNEAYHMDPVELQSFAIQVANGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVX2</accession>
    <name>A0A183HVX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017045">
        <property type="protein sequence ID" value="VDO77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVX2"/>
    <dbReference type="STRING" id="387005.A0A183HVX2"/>
    <dbReference type="WBParaSite" id="OFLC_0001163401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001163401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001163401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001163401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17681" checksum="500AD9BA5ACE1C4C" modified="2016-09-07" version="1">MKGIIWKSITPRAPWSGGVYERLIGLTKNSMRRCTGRKLLIQKDLITLIVEIEGILNTRPLTYVSFDDYVIMRSIDFISPNASLVNQIFDEEDQNEYTPFRMSSQEKLIKYWSRTNEVLDKFWEYWKREYLNSLKERTQRNHISPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX47</accession>
    <name>A0A183HX47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12059</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018225">
        <property type="protein sequence ID" value="VDO81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX47"/>
    <dbReference type="WBParaSite" id="OFLC_0001205901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001205901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001205901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001205901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4072" checksum="2CD04010ECCB951D" modified="2016-09-07" version="1">MFFGSMRKLSKLSGNLLVSMMRFLISVFSDQNWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX76</accession>
    <name>A0A183HX76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12087</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018308">
        <property type="protein sequence ID" value="VDO81790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX76"/>
    <dbReference type="STRING" id="387005.A0A183HX76"/>
    <dbReference type="WBParaSite" id="OFLC_0001208801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001208801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001208801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001208801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5154" checksum="70BAF8F2C469575A" modified="2016-09-07" version="1">MAPPQKQPLVRVYNKPHGVVRRASEKRPMPPMKALAQFRTANINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXK5</accession>
    <name>A0A183HXK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018678">
        <property type="protein sequence ID" value="VDO82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXK5"/>
    <dbReference type="STRING" id="387005.A0A183HXK5"/>
    <dbReference type="WBParaSite" id="OFLC_0001221801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001221801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001221801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001221801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="478F25DD03AEBFD4" modified="2016-09-07" version="1">MNRLSRFATISSRTIYANTNLSRLIPGSLENHECAYPIAGKKTKIVTDIKDAFGAIKSGRHIVFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXX2</accession>
    <name>A0A183HXX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12337</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019052">
        <property type="protein sequence ID" value="VDO84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXX2"/>
    <dbReference type="STRING" id="387005.A0A183HXX2"/>
    <dbReference type="WBParaSite" id="OFLC_0001233501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001233501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001233501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001233501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14211" checksum="94028338BC357718" modified="2016-09-07" version="1">MWLVVLRFGNSYSESVLIISKFSNHKFQNSKKWFATQRDASNGNSNVECASTNNSPEVTGKHRENLNDAAYQFSPFQEPPFIVVPPHLLRPLDILINEGQKYSSGDAYKHWLSTGTAQSNDIQLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXX8</accession>
    <name>A0A183HXX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019045">
        <property type="protein sequence ID" value="VDO84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXX8"/>
    <dbReference type="STRING" id="387005.A0A183HXX8"/>
    <dbReference type="WBParaSite" id="OFLC_0001234101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001234101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001234101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001234101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7965" checksum="218A05824EDD349C" modified="2016-09-07" version="1">MLPHNSFSILEFYQSGCNLLEHSKISSLDYAYQIVHPSVSAFLPPEKPCHWTEVVKRRTFCVRLYRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYD3</accession>
    <name>A0A183HYD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12495</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039855">
        <property type="protein sequence ID" value="VDP11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYD3"/>
    <dbReference type="STRING" id="387005.A0A183HYD3"/>
    <dbReference type="WBParaSite" id="OFLC_0001249601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001249601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001249601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001249601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25251" checksum="00083FA3AEBB6B3B" modified="2016-09-07" version="1">MRGSHDLFTPLSGTAGGGSLLASNLRGVTLDNEAKKVCLFYSNWKKAKLDRSVNLLTTSGAMVLPSLQQQLLSAAAFANGAQLLQNSALLGQAFTSNNNPSSMIATTSTSTTSGNTGQHVSRVVHLRNIPSDMTDLELIHFCMPYGKLVNYLLLKGRNQAFVEYEDERSAQTLVTVNIACPVAIRDRTIFCQFSTHQELKTNRRPRVGSNESNLINDQDDNEVFLFPSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYT2</accession>
    <name>A0A183HYT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12644</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039891">
        <property type="protein sequence ID" value="VDP11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYT2"/>
    <dbReference type="WBParaSite" id="OFLC_0001264501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001264501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001264501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001264501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3978" checksum="253CFB7D7731D977" modified="2016-09-07" version="1">MLRYFSQMLSMPLPILQLNSVEVFPFSYISPQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH7</accession>
    <name>A0A183HZH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Core-2/I-Branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12889</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039965">
        <property type="protein sequence ID" value="VDP12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH7"/>
    <dbReference type="STRING" id="387005.A0A183HZH7"/>
    <dbReference type="WBParaSite" id="OFLC_0001289001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001289001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001289001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001289001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48262" checksum="50E96B08E7F8E98B" modified="2016-09-07" version="1">MLSTVLWIASFRRSIGDVNILQSSNQQMKNLFNASAKANVEELLLETFEAVKQKYVVRVNENSDEHLDTSCDAIRQRAFYPATSFSSDEENFPIAFVRIVYKDFHLQELLLNLMYAPHNLYCYALDAKSTSLFHEQMSNLSKCFPNVLLTQREYEVDSAGHNTSRSFLECLRIIRSLPGWKYAVLLQNNDIPLKSNREMVQILNALNGSNDLNIGHPNADRVPSGAPWTFREITLFNDDKQNDDRKLRIAKGSTAASLSYAFVEFVVDKLNLTILLDKFDHLSYGGDEMLFSSLNSEDSLDAPGGFTRQCIGVYNNMITRYVVWKKSTKPCRSGYYRHDICIFGIADLPTMSTSTTLFANKMLPEYDYTAIGCWANALHNRTFSAVKITPKKLSYYANRLPVRFHNERERWKSNLSAFDCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZN2</accession>
    <name>A0A183HZN2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12944</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01039985">
        <property type="protein sequence ID" value="VDP12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZN2"/>
    <dbReference type="STRING" id="387005.A0A183HZN2"/>
    <dbReference type="WBParaSite" id="OFLC_0001294501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001294501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001294501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000023">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552707" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001294501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26397" checksum="164B949DD430215B" modified="2016-09-07" version="1">MFRLVVALILSLQFVLYSAAQDASVEEDDGVLVLTKDNFDDTIAAHEFILVEFYAPWCGHCKALAPEYAKAAQLLKKEDSPIKLGKCDATVHGELASKYEVRGYPTLKLFRSGKPQEYGGGRDAAAIVAWLKKKTGPAAKTMLSADDVKDFQENNEVCVIGYFKDTESADAKVFLEVAGGFDDIPFGITTENDAAKQLELKNEGVVLLKKFDEGRAEFGEKLVADALRSWVQVLFVFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0H3</accession>
    <name>A0A183I0H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040102">
        <property type="protein sequence ID" value="VDP13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0H3"/>
    <dbReference type="WBParaSite" id="OFLC_0001323601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001323601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001323601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001323601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8996" checksum="ABF9E4E21CF3CB44" modified="2016-09-07" version="1">MWRGKFEVGKMTDMRNMEDDNANDLPMDQSAVAFDDVLDELLEPDRVLHAGHFLGICSTEGWISAVLFCIYDIMKIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I182</accession>
    <name>A0A183I182_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AMOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13494</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040230">
        <property type="protein sequence ID" value="VDP13901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I182"/>
    <dbReference type="STRING" id="387005.A0A183I182"/>
    <dbReference type="WBParaSite" id="OFLC_0001349501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001349501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001349501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056075">
        <property type="entry name" value="DUF7658"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057017">
        <property type="entry name" value="F54D1_6-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF60">
        <property type="entry name" value="PROTEIN CBG06057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24678">
        <property type="entry name" value="DUF7658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24469">
        <property type="entry name" value="F54D1_6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001349501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="806" mass="91986" checksum="1A4C1C4594E82CD5" modified="2016-09-07" version="1">MIGAKNCYMSAQNIYGSYAGDGSSYESEKTARFRTHYGQVCCYDEEGKLMQTTYQPVIKVTDDTPYNPGFPLRAYEFGTDPYIGQFEVPGLSTFYHDYMPYFFCCKYAKFRCQLFYWRRPSSGCQQYQPPAVGEALGAVSFNTIDNDKFIFNEPGVFTLLYIPKTVTTPEVRIQVRLERYPDRRVDFSLLGRQIGQANLVQPTNATVITGIAIEATGTDRVHVVARKDTRRFRYRTSVIVGNILRYFDVMRIQRFRGVMVYVNNVERGQPEIYVVLEEAQVGIRIRESYNLDIDRLSMYQESMGLLDIELSVPPQYGVRPDGDKTREQDMRTRYNLPRVSGLMRPFPDQTSASFLSGLGLNDVNAEGIRQQIISNYLIPGTGETSSRQTVAGTLSQNIPTDNMFTTSQDIDKKFEVFPEVHMKSEPIYKTSAEYETGRYRFVPMTGHMLSQRLQTCRDLQLNDRTNWQPLQNLYEQQYGFHYCPDNPSQIIQECGDSVSCLNDYTLFNARVLGMEAQNSWNSFSNDRMHASRHYNSCGPIMIEYPEYLMKTPVLSSGYLEGDVARFDCFQTHWIKGDYEYKCGIVVDYNDPQSYRFEWNKGSQPWCRSREKDNLFKWLTAIFSTIGIIMAIVLIFLCCWTLKQKRRQQAEEKISSLYKVPIRGSMSSETKPFTKARTDSMSSETNGMYQGNENDLQYRGGPVSGAAPVLAEDNEAYRGETKGPYRVIDSGAPYHEQYQESMANLARRPSSPVKTTVIRSSKTVPIGISHVMPQSTSSTPPVPPHSRLTDEQNGGDHAQLLGLNTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I185</accession>
    <name>A0A183I185_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13497</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040231">
        <property type="protein sequence ID" value="VDP13906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I185"/>
    <dbReference type="STRING" id="387005.A0A183I185"/>
    <dbReference type="WBParaSite" id="OFLC_0001349801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001349801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001349801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP13906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001349801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44403" checksum="ECD7EEAD125B0546" modified="2016-09-07" version="1">MQGKLLKWYSFIFRKQQSSTALVLFSRIPRNHGQTGGHRKSYSGQNHWRWFTRSAAAPLLGFSLMTTFKDLVGTPPFKLDKDPLKQKIKKAWLYRKERNYDQAVVVLEEAMEMAIGQNNELIVSRIIDELANTYYEMGKLDKAEQAFRGLLQRLITLHKKQDHDPEFIDVSLKLSDIFAQKGKIDDAEIGYKHCAAKQMKVVEKHMAKYSINYGGSYDIPQVINQYGAVFTDPLALYGLCLEQYAHFIVRYREEKRLDDTAQLMDEALKISHQIYGINCFHTINMLNNYGALLIARNRFDLAKKYLEIGIDRILYIDECSTLLPGYYCNYSEALYHCGQRAEALQYAKKAVHLSHSESKELQNYTMRFLQDMEKDYNRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1E2</accession>
    <name>A0A183I1E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPLB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040261">
        <property type="protein sequence ID" value="VDP14055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1E2"/>
    <dbReference type="STRING" id="387005.A0A183I1E2"/>
    <dbReference type="WBParaSite" id="OFLC_0001355501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001355501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001355501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001355501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22722" checksum="3157B914BD9A5411" modified="2016-09-07" version="1">ERRDREKEREKKERKRSRSRTPHKKDDRRERDKDKDRKEKDRESNSRRDKEKNNRSEKNDKKEEKDCDKGKKNSRKEKERERNSRKNDNKSNSVKTEVKLQIEHGESMEVDHPEQITASDETAMRERLMEKVLARNGPKKNESMDIEMVDIDKEKNELQSKRSTSVDRESLRKKSRKHSESSSTSSHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1F0</accession>
    <name>A0A183I1F0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS13562</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040267">
        <property type="protein sequence ID" value="VDP14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1F0"/>
    <dbReference type="STRING" id="387005.A0A183I1F0"/>
    <dbReference type="WBParaSite" id="OFLC_0001356301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001356301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001356301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001356301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="890" mass="101992" checksum="CA0ED142C672CD36" modified="2016-09-07" version="1">MQTRAIMTIAPNMRRRADMTALFSIDQVKYECSCGEWESLSRLYFCRHCSEIRCMLCVSQEMDTSFCPSCLDNVSTGEARQKKNRCSNCYQCPICGVSAVIRASNETYHLSCNTCRWTTTDSNIPDSTSSTTWPQYQLEDEQLLSAFLERMRNYAAVERADRERHKYSKRRSNLGAVLSDRFGLQTMYNRRKAALAERTEKKFPTLEPTDDIMPLDDSIFDEQEIDIGSIATLMQEAKQPLANGRPLLPIRTPLAGRHSIRCKQCDHSLCKGEYSPTSIKFKIQVLAGNHVPDIRLSRRTALVSNQWCPLFLTVSNFSTSLARVVIIPYTNEDESYVKCDSPVIELSVPNRDDAMEWDETFEKSADENEGLVTLPLIVFRQRHRIGIRFNVYSTEGADRKLALIVKYSNCIMGTKTGDEKFGHALHDDLTLSAICKKIKQKESEGNRRVRLSRRAWKYRIDDDESEKEARMQRCAYISRRTQLACKNYRPSSELTVEGFCEVHTHFFQQLAQHAVAEQRRIEKTLLNKPKEICAVIDDETLMTVKDWTCAEQDLFNDLLLDDDDGDPLKNAEVWTDEEVIRCQLIALERKLSVTRDLRKLIAEKVRRLTASYAKSMKEDQKKGKTKVEDSRLREIQLANRKYHSYHSAKDQYMLRRLKARLEWDGSEEHKLDYLKTDNIKDGAQCIFFISENNVIPNNKCHEAVTGSISKTNDEPIEKNFEHDSHIIIRRLLNELCEQIEQALNSGRDLINVSPKNGNEVEMKEGHCCSSWTLPKLNHCVAHIYDDRRQHLFAPCTECGALGLDFGDGLNFCLRHIARRNQASLNTVEHWKTMTVQRGVIPMSNTSDIHNTLSIGQTQSDVKSGSKSLADSSTTVTNIRGQLIHFSCLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1R5</accession>
    <name>A0A183I1R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13677</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040329">
        <property type="protein sequence ID" value="VDP14365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1R5"/>
    <dbReference type="WBParaSite" id="OFLC_0001367801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001367801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001367801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001367801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10053" checksum="F614634FF9C5E599" modified="2016-09-07" version="1">MCDGRLGVLTGIAVIISPVSVFSDALATSSRKLDGGAVSVCGWKSKGEKGIGRIIMGSAMKWVSSRNSANHQTSISSAHAPPCFTRLRSPPQRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2G9</accession>
    <name>A0A183I2G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13931</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040478">
        <property type="protein sequence ID" value="VDP15040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2G9"/>
    <dbReference type="WBParaSite" id="OFLC_0001393201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001393201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001393201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001393201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7923" checksum="78E15D1BAB702CD4" modified="2016-09-07" version="1">MIVFIYRLKNRWTGYDDGDLAFAAKLRAQGLPIAAYNMREYFASINLKHESERQQNKEIATTKIAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3J2</accession>
    <name>A0A183I3J2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14305</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040752">
        <property type="protein sequence ID" value="VDP16425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3J2"/>
    <dbReference type="STRING" id="387005.A0A183I3J2"/>
    <dbReference type="WBParaSite" id="OFLC_0001431201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001431201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001431201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP16425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001431201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11509" checksum="BF020E4797EAC190" modified="2016-09-07" version="1">MESRILGSNSPYAPAALNHKRFAKMPRQITEIKEFLMTARRKDAKSVKIKKNPDNVKFKVRCSKYLYTLVIQSLLLASHKMRLIIPIINSCGSIFGWMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I421</accession>
    <name>A0A183I421_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14483</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040893">
        <property type="protein sequence ID" value="VDP17256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I421"/>
    <dbReference type="STRING" id="387005.A0A183I421"/>
    <dbReference type="WBParaSite" id="OFLC_0001449101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001449101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001449101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008766">
        <property type="entry name" value="Replication_gene_A-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05840">
        <property type="entry name" value="Phage_GPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication gene A protein-like" evidence="5">
        <location>
            <begin position="76"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP17256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001449101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58719" checksum="EF2D4DC9E3BC8072" modified="2016-09-07" version="1">MVRSYYPSECHADYFDFERIEALKPAIEACGISTLSQSPMLGFHKQMDNRIKLLEEILSFRMQGVEFDNGDMYVDGHKAASDVRDEFVSVTEKLMDELAQCYNVLPQLDINNTIDHRPEGDEKWFLENEKTVTQFCRKLAAERPLKDIRDEYNYPKKKGIKDECSRLLEASTMKSRRGFAIQRLMNAMRQAHADGWFIVFDTLTLADDRLEAFYDNPNALRDYFRDIGRMVLAAEGRKANDSHADCYQYFCVPEYGTANGRLHFHAVHFMRTLPTGSVDPNFGRRVRNRRQLNSLQNTWPYGYSMPIAVRYTQDAFSRSGWLWPVDAKGEPLKATSYMAVGFYVAKYVNKKSDMDLAAKGLGAKEWNNSLKTKLSLLPKKLFRIRMSRNFGMKMLTMTNLSTECLIQLTKLGYDATPFNQILKQNAKREMRLRLGKVTVADVLAAQPVTTNLLKFMRASIKMIGVSNLQSFIASMTQKLTLSDISDESKNYLDKAGITTACLRIKSKWTAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I451</accession>
    <name>A0A183I451_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14513</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040915">
        <property type="protein sequence ID" value="VDP17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I451"/>
    <dbReference type="STRING" id="387005.A0A183I451"/>
    <dbReference type="WBParaSite" id="OFLC_0001452101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001452101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001452101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001452101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11356" checksum="78CBC1422CCDE057" modified="2016-09-07" version="1">MDTSFSFLSQIPNQEGYLVVSTGSVIKSDGELENNESLAMNVQKMLYVGEPLAHIVGKIEKMTITYPEYNLEVVRSGKYTLFYEVKPLIFSANHCTTNQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4T7</accession>
    <name>A0A183I4T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vps16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14749</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041158">
        <property type="protein sequence ID" value="VDP18579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4T7"/>
    <dbReference type="STRING" id="387005.A0A183I4T7"/>
    <dbReference type="WBParaSite" id="OFLC_0001476001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001476001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001476001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="3">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP18579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001476001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19636" checksum="EF2CB2809BF945A2" modified="2016-09-07" version="1">MKNPETPHKSFIIDIEIKLLRDVKKLLETMKIQEATEFIEKNNHPKLWALLAEVALNRLNTVVAEHAFVMLKDYAGIQLIKRIKALQHDEFKKAEVATFYGRIDEAEKIYMVNDRRDLALELREKMNDWFRIVEILQESKQPGDDELLKKAWNHVGDYYVERQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I515</accession>
    <name>A0A183I515_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14827</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041253">
        <property type="protein sequence ID" value="VDP19051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I515"/>
    <dbReference type="STRING" id="387005.A0A183I515"/>
    <dbReference type="WBParaSite" id="OFLC_0001483801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001483801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001483801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001483801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45062" checksum="114697AB5CEDCB06" modified="2016-09-07" version="1">MEEKDCPNGSQASEIRFTQCSMRNTFGLRFLYLFFNIPFLYLQRETLMGQLETNRRDIELSFDELDMYEETQDASYDRFMENMATRRRRAAEKVAPIPVSDGTRSGLPFGEGRPIPFGGPNCHLPRPSSSIASHSPNITSPSLNRTTSRNHSATSDIIISSLQADNNERIINRSAPINDTVSNNSDEEVNNMVTMYEEDVPSEEEVQIKKINMAQKQTTTLDSSRLFDKSKHEPQTPMAYKVPIGSLLRLVKKAMISITEMYYSWIISYRNALFFSEVICAEHIYESGPNPLVTSIPADSETEDEVGHHSVTSTRIDYPSTGKDDTNESKAISGIVGMKPKSKTKSSSTKKASSRKSDKGTRNKGKFDKGSDQRRTEIFSDRDFLEREFTVDPSSYDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I605</accession>
    <name>A0A183I605_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15167</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041708">
        <property type="protein sequence ID" value="VDP20668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I605"/>
    <dbReference type="STRING" id="387005.A0A183I605"/>
    <dbReference type="WBParaSite" id="OFLC_0001517801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001517801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001517801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF72">
        <property type="entry name" value="PROTEIN UNC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001517801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11103" checksum="4050F2221131AA4A" modified="2016-09-07" version="1">MSSKNARTDPQWVTPSSNQDVPPDYETIGTIFGYALLVLSWILIIITFPFSMCVCLKVIKEYERVVIFRIGRLVFGGARGPGMIFVIPCIDTYRKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8D8</accession>
    <name>A0A183I8D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043549">
        <property type="protein sequence ID" value="VDP25833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8D8"/>
    <dbReference type="STRING" id="387005.A0A183I8D8"/>
    <dbReference type="WBParaSite" id="OFLC_0001601301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001601301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001601301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001601301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15024" checksum="FD55C0A9264E689A" modified="2016-09-07" version="1">MKHTEAEKLFLEKMAVLNKTFLYFIQCSLKEMPDADLSPCVRDYLKHVEELDQTYGNIEIVSNGGSTSTSTENGKKGEVTNELLKASPSQKDVNDGSGLIVKSSAAQEKPISSEINIFNSTTNPASVPKISFDTSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8Q1</accession>
    <name>A0A183I8Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01044132">
        <property type="protein sequence ID" value="VDP27369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8Q1"/>
    <dbReference type="STRING" id="387005.A0A183I8Q1"/>
    <dbReference type="WBParaSite" id="OFLC_0001612601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001612601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001612601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP27369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001612601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6447" checksum="FCCAE47B63621804" modified="2016-09-07" version="1">MRNYNVRFAHGPHELRIARFVYPGSHRYDYEVRMNSSNTSSSSCRRVGYLEEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U2X7</accession>
    <name>A0A3P7U2X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000163">
        <property type="protein sequence ID" value="VDO25969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZ28"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="444" mass="50163" checksum="B7963FF19D7B7119" modified="2026-01-28" version="1">MWQLCAIVFVAWFDYCIAYDTVIFSTLKLKKMAVEDLAAFSKVLAIGIKDFSLPNFGVYAQAYNVENSDGPFASIMPIFPYRKALPMENPFLVASSNADRSVQKTDENKKQMRKKTDVNYISFDTFEDLRDILSTAENFKDYEMVIISSREAFEKELIRRKRVFSDHIFDEEPSDKASETRRQKQAGSGQRLSAADRHDMPVVLPPPIPSQKTACLLYMEAFDIIITNSHFLTVNSEGKNKYSVEPDHYKCNVSNSQGGASFIIEVEVGENIEDAKKEFSLKSGTTITFQLDFIRSQNGYWYLNGTTLKNNFKITAIGSKEDLTVNADTTMNRVDVGAVFNQNFACYQTDAAMFNVSGDKNPIRVGISLRNFEVALGLTGDETKFGYYTSDCIGTFSAGTWMGIIISIVFISILLFGYLMVQSIQTMDRFDDLKQKPIVINFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UJG6</accession>
    <name>A0A3P7UJG6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brf1 TBP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001934">
        <property type="protein sequence ID" value="VDO35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UJG6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brf1 TBP-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="412" mass="46750" checksum="AA15D2E41C562C25" modified="2019-02-13" version="1">MTFYIKFHNLARIYIYFFFRRHEREEEEREKDISTRKRRRTNGVRKKEPIVAATAQEAMEKVIHEKKLSNKINYDILKEIEDADETVIKTEIETSTNDPKEETSGIIDRMLFKDNRNLTLTTGKTLKTRKSFRPNVNLATKRAVEQTISVIAASDVQKNVCQKEKESMKDLSITNEEDILFVGGMETNKRKWTTIQYQATNNNIRATTTESSISSTGMEHSNISTSQPKTDGVDSMQAGTSDSITEFPENVSCVMRKRKPRKSYVGKNSESVDVNSKNVVEVVGNSPSEKPRMIKTRYAKMRPNLKSIQKSEKSTGQDGQQSSLAVVSEVPREASTEDKGMQQKKEVTEVSSTPTSSEIETISAENVSKESLGQGTSKIYTAKTETNKAVTIRKTRSRYLKMKPNLLKRAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VFF6</accession>
    <name>A0A3P7VFF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000868">
        <property type="protein sequence ID" value="VDO30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H2L9"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="185" mass="21309" checksum="40FA69A785DD7103" modified="2026-01-28" version="1">MLAMINRVLDWIRSLFWKEEMELTLVGLQNSGKTTFVNVIASGQFTEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVNAIIFMVDAADEDKLEASRNELSQLLDKPQLDSIPVLVLANKKDLPGALDERQLIERMNLSAIQNREICCYSISCKEKDNIDITLQWLIQHSKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W447</accession>
    <name>A0A3P7W447_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009574">
        <property type="protein sequence ID" value="VDO55740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W447"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF9">
        <property type="entry name" value="FI06469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO55740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="120" mass="13877" checksum="B17222418522CD51" modified="2019-02-13" version="1">MCLQVLQCGKAGYLSVGLELNIPLILYSRWRARREHLSHLTKFYRKDIFKADLKQYKTAIIFGTETLMNDLSVKITEMKIGSFLIACRFPLPTSEANTQWLLLCTIGNGFDGVWLYEKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WQX0</accession>
    <name>A0A3P7WQX0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007206">
        <property type="protein sequence ID" value="VDO49397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WQX0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO49397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="98" mass="11422" checksum="68D532034F5FFEDB" modified="2019-02-13" version="1">MIPDHLKCLGYALESARLVFEKRFDTWLCPKCIYCCSCKEFIYDPENVQCFACDEAFHGICRSTSGAWKNPKDPLSSWFCAKCKHLMNIENRSIYKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C1M4</accession>
    <name>A0A3P8C1M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039958">
        <property type="protein sequence ID" value="VDP12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZF6"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="540" mass="58701" checksum="84D10F9E65795988" modified="2026-01-28" version="1">MLSRKLLLTAARVSKASSNSFGTSSRFCAAGAEVLKILEDRIRGQESTVSLEETGKVLSIGDGIARVYGLKNIQAEEMVEFDCGMKATCLKGMALNLEPDNVGVVVFGNDKVIREGDIVKRTGAIVDVPVGEALLGRVVDALGNPIDGKGPIKCMERSRVGVKAPGIIPRIGVREPMLTGVKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTIINQKRFNEGSDEKKKLYCIYVAIGQKRSTVAQIVKRLTDTGAIKYTIIVSATASDAAPLQYLAPYSGCAIGEYFRDHGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDSHGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLDAATQQLLNRGVRLTELLKQGQYVPMAIEEQVAVIYAGVKGHLDKLDPSLITVFEREFLTHIRQTQKELLKTIREEGQITPQTDAKLKELVTSFITSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C2S8</accession>
    <name>A0A3P8C2S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017258">
        <property type="protein sequence ID" value="VDO78572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8C2S8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="52" mass="5524" checksum="3D056BEAEB74EFFB" modified="2019-02-13" version="1">MLQIAKHRKAVAVTISLSAIATIIIITIAVAAGAILQCSLCYDQFIPENIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EQY2</accession>
    <name>A0A3P8EQY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039865">
        <property type="protein sequence ID" value="VDP11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYI4"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15718">
        <property type="entry name" value="FYVE_WDFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="411" mass="46284" checksum="6382F897F9F3179B" modified="2026-01-28" version="1">MAAVINAKPSSLTRCSMGVGKPVLLHKIEGQISRVNGIHLLSTEEGVLTISDDRSLRVYLKRDNEQFWPSIYHYLPFSPSSMHFDEYKLRLFVGLINGSVYEYKVAEDMNSLSEQRHWMAHLSLVSSVLYSSEAELIFSCSKDKTTVWHCSETSVKMGSYAGESSFTALEFDVSSKFIFLGDSSGGVILLRLNGSEVNIVTTLSAHTNTITSLAWDSERQLLFSAGADHLVIMWDIGGRKGQAFELNAHNNRLTCLRYAQHKKRLFSADEDGSLVCWDMTAKRVETPGWKTSDSCQLCDSPFFWNFREMWDKKVVGLRQHHCRTCGNAVCAKCCANTTRYPPMGYELPVRICNACQSRMQQFPDQFDLTSLAVISKLHQGVVCMHLQESTGRLVTAGSDRILMIWDVKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXQ6</accession>
    <name>A0A183GXQ6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="13">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS16</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Possesses 5'-&gt;3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with paxt-1 (via N-terminus); the interaction is direct and results in stabilization of xrn-2 in the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="13"/>
    <dbReference type="EMBL" id="UZAJ01000005">
        <property type="protein sequence ID" value="VDO24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXQ6"/>
    <dbReference type="STRING" id="387005.A0A183GXQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000001501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000001501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000001501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="14">
        <location>
            <begin position="61"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="15">
        <location>
            <begin position="399"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="15">
        <location>
            <begin position="622"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000001501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1087" mass="126077" checksum="187D4E6B365EF09E" modified="2016-09-07" version="1">MLKRIPTPANSYDPIHQIPKLKSCMPGGWDHNFRSTHFKVTYCKIWAESCREDKKDSTVTMGVPAFFRWLTRKYPSVIVDAVEEKPRDLNGIRIPVNTTDPNPNFQEFDNLYLDMNGIIHPCTHPEDRPSPKTEEEMFVSVLGDRIIFYTNRNAVLIFEYIDRLFAIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRASKEAVEKVEQIAEIRSRLESEGYPLPPEKEKEHFDSNCITPGTPFMARLAVALRYYIHQRLNSDPGWEKIAVILSDANVPGEGEHKIMDFIRRQRASPSHDPNTVHCLCGADADLIMLGLATHEPNFNIIREEFVPNQQRPCDLCGQYGHELNDCKGLALDDNSECQSSPLQKETNFIFVRLPVLREYLERELYIPNSSIPFDLERAIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVKLYKDMVCEMKGYLTDSGIVSIQRAQIILNKLGEVEDEIFKSRQEREQQFKRKNKERKWRERAFMAPSYIPSRDSLLAPQTNGPMYFSGSSTRAMARTARLEVMGNFSCINCTGMIFSNFFRATGRTFYVITYDGALNFPDTLRTQTVNNVALHIPATNMSENNDRKHKLRYIKWFCVFQVIYVSQTSHFLFFQNNDSSSEDEISDEVRLWEDGWKDRYYKSKFQVDGKDIVFRRKVALAYIEGLCWVLHYYYQGCASWDWYYPFHYAPFASDFDAVSEFKLDFSAHTEPFKPLQQLMGVFPAASRMHLPEAWQDLMISSASPIIDFYPDKFVIDLNGKKYAWQGIALLPFVDEKRLLEVLKPDIVSGTVLLNVNHVLKMEDKLDAFEKERNSRGPDRLFVGSSHPFYKFAEQLYEGDKEGSIALPIDTSLTFGMAGTVGADAKAIMKGENYKSPFLVNEFADIAENKAIMMIYKDPQFEKGYVFAAKRLSGAIDVPRTLKDINLDRKEPYRPQIGFSREIPRHGLSDAGRRMLGHNIGHGPRPLFEAYQIDSHNRPHQSSSWIPAGSYAEDRMPNYSPTANQFRERRQTGGEWYGNSRRYRNFNEYERISQLPLPLRHPFRYEPYPELISSRARSRGRDRPLQHSVYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY16</accession>
    <name>A0A183GY16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 36, C3H1 type-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS126</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000031">
        <property type="protein sequence ID" value="VDO24647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY16"/>
    <dbReference type="STRING" id="387005.A0A183GY16"/>
    <dbReference type="WBParaSite" id="OFLC_0000012501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000012501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000012501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF185">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO24647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000012501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="19013" checksum="1816CBB29A5B8E70" modified="2016-09-07" version="1">MEREMLRRRFDPRVHNRDLNICEWFQWFQFVYHSQLLLAERKKKRKAETHKTVPCQAWKDTGRCNYGKRCKFAHGPEELRPMPKAEVKIFNNPRYRTALCTKYATFGYCPYGDHCHFIHDPIQVDLEKCLDWLSESSLSSQLSPEQTGNYLNVASFSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYJ8</accession>
    <name>A0A183GYJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000090">
        <property type="protein sequence ID" value="VDO25334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000030701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000030701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000030701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000030701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37201" checksum="8C8BA77D8DA596DC" modified="2016-09-07" version="1">MQLFTWYVPLCRDVPSQRTQSESSINVYDKVYEHIPEQEEASVEDAGRSTLINDVPSCSNASSSKLAFSLSIPEAIILPTDRCASTDMRQNLPVPSNMAPRHDIDKTLATAYPEMQPSAVTSNLRDFFTKQSESSHFSNEHFANHVSDDIAINTFDLETFTGRERSIRNLAFRSKENESVEAFESISSSENNSLKKCMLNNKKIPDSTITFTLSKNGDRQMAYDDSCCYCNIIALQKDARLTFSNYLLLFATCYLHNVCTSSSAVQCLGDELDRSIGSSDTFENKAIVQESGVQRLDEAQLCLNLFMNGGVTSLLAGNSSSDGLPETKRSNFTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H057</accession>
    <name>A0A183H057_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS867</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000348">
        <property type="protein sequence ID" value="VDO27373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H057"/>
    <dbReference type="WBParaSite" id="OFLC_0000086601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000086601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000086601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000086601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15781" checksum="3ECF09AD17A7BAF5" modified="2016-09-07" version="1">IRISGPKLLIRSTGNALHSVELEDAYDTWLKYVQTIAATKKRENEENAYKQVTESKHGLLRIIHERKEELITLTKAKCLIDEMQHDAKETAGVDVPEEKKKYSPSIESTEASKNLGVQVIKQGKGLIIFLASRTLIGGISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H062</accession>
    <name>A0A183H062_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS872</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000351">
        <property type="protein sequence ID" value="VDO27401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H062"/>
    <dbReference type="STRING" id="387005.A0A183H062"/>
    <dbReference type="WBParaSite" id="OFLC_0000087101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000087101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000087101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO27401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000087101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="54046" checksum="9E262EE8787CFC39" modified="2016-09-07" version="1">MAKQILQNQTKESQNHSQQYGPMNEGNVIIIDAKTKNTFLNRPKLMTQNKRKQKSGGNGLMMIAILHLLLACGLIDLGMFLSIRFNYYGYIWPDSYLKLTVSEYRLYHNQMLSIRLLYSPVTIAIGLMIFFPKSIYLLIIFFSKVSFCRAMIVDGIISFIALTYACITGSHAYVILHNISRINIGDNSDILCYAIRGPREKAPQALRDRCLLVAYKMFGNHLSLQSIIAILVIIEWGRRIERTFSDMLGTFVQLMLLSVVLLLALVFLYARYVSRHSYVNKKVTKWKRLPSTSIRMCCVAGSGGHTAELLTIMSAFKEQFGYYIYIVSDTDKLSEKKIIEFEKLRGLKNFRIERISRSREVKQSYITSLFTTIVACIESLFLVWQIRPDIVLCNGPGVCLPICFAVALFDLLRLLDVRVFYIESLCRVKKLSLTGQILYESRIPDIFFVHWEDLVQRYPRAVLIPCTECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0E1</accession>
    <name>A0A183H0E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS951</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000393">
        <property type="protein sequence ID" value="VDO27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0E1"/>
    <dbReference type="WBParaSite" id="OFLC_0000095001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000095001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000095001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000095001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="4752" checksum="518965F5E73F47C9" modified="2016-09-07" version="1">MGKESSSREKVSWGEVVINLENVESSHCASFSSLIILFHLTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H173</accession>
    <name>A0A183H173_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1233</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000548">
        <property type="protein sequence ID" value="VDO28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H173"/>
    <dbReference type="WBParaSite" id="OFLC_0000123201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000123201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000123201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000123201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8472" checksum="B6EDC5F92226BD65" modified="2016-09-07" version="1">MESISDSTIQIQYLEFREQWLRNTMHCTMYCSYVPLFFSAFGENSWRTGEKSLDDAFRTRSNSSPLPRLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H248</accession>
    <name>A0A183H248_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1558</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000758">
        <property type="protein sequence ID" value="VDO29974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H248"/>
    <dbReference type="STRING" id="387005.A0A183H248"/>
    <dbReference type="WBParaSite" id="OFLC_0000155701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000155701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000155701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000155701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9926" checksum="B4ADDD4E72CFDA4C" modified="2016-09-07" version="1">MVEYYQQLPSSNYYQQQPGHDYTQQEEEWDREGLLDPTWEKQQKKTFTAWCNSHLRKAGTSIEIIEEDFRNGTSKFFFCFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H428</accession>
    <name>A0A183H428_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001244">
        <property type="protein sequence ID" value="VDO32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H428"/>
    <dbReference type="WBParaSite" id="OFLC_0000223701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000223701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000223701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000223701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27223" checksum="BB0D6514048418F0" modified="2016-09-07" version="1">MAISQQFLDSQPSTSIEEIEKEKTKEDKAVIGLVTSSFNGKAFVWSSALGKGIISLYFGEQVRHGDWIKFIPSFMNDTCLQEYDESRQCRYTAKDWCIISPLYPTRSYKTTVSVQVRLFIPKSSSNLWAEFFGTVHDSLGRIAEFGSSNCVLGRCFLVWIMEMKSNDGSSRWVIHKVLKLLENKESVPRLESVSFAADALRYMNEDLRIYSAMKKVDWNLVEQLREPHLLSDNILKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H439</accession>
    <name>A0A183H439_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras-like GTP-binding protein Rho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2249</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001252">
        <property type="protein sequence ID" value="VDO32369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H439"/>
    <dbReference type="STRING" id="387005.A0A183H439"/>
    <dbReference type="WBParaSite" id="OFLC_0000224801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000224801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000224801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO32369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000224801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21156" checksum="2B41187BF13C24B2" modified="2016-09-07" version="1">MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENISEKWTPEVRHFCPNVPIILVGNKKDLRNDPQLVRELAKMKQEPVRPEHGRAIAEQIGAFAYLECSAKTKDVSLFFSDYATFILSNNPNILISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H474</accession>
    <name>A0A183H474_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Abhydrolase_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2284</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001279">
        <property type="protein sequence ID" value="VDO32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H474"/>
    <dbReference type="STRING" id="387005.A0A183H474"/>
    <dbReference type="WBParaSite" id="OFLC_0000228301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000228301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000228301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018795">
        <property type="entry name" value="K2013-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2510039O18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN KIAA2013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10222">
        <property type="entry name" value="DUF2152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000228301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46490" checksum="421E1EA11EB7AA41" modified="2016-09-07" version="1">MLSSLRRVQCRRWDDFELRKWLRQLSIPRRVSLTAALILFSLYFIISSLTSSPYVAESQKCLNERLNAWKVLKNDDFVAIFDKKFGFIGNGFIGMGGDGELRLKTSRVLSIRSAFFSLINAKIRDSESFAESYINDYRDGSIITLRCYRIEDQCVCTTQRVYAHRRRPHLLIQELQVTNPSNSDIKIDLSMKIPEYWTQKKSNNLADPVYTRYFESDGAHTLAAVACTKIPESVTVEQKHEISLHFICVINYISPLPIGRNENDELKLLNESVIKEFADYASLDGTVLYREHSTAWHKLNMVTFGISKSLAPNALNADEINSTRYILLSNVRDPLLEIGVSKEQKETAAASMKVIDVCYTGHSTLLIPSRLWRKSDNINDIIETMDIWLLTLEKRGCAGLLKAGASGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4I6</accession>
    <name>A0A183H4I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2396</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001371">
        <property type="protein sequence ID" value="VDO32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4I6"/>
    <dbReference type="STRING" id="387005.A0A183H4I6"/>
    <dbReference type="WBParaSite" id="OFLC_0000239501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000239501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000239501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000239501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9615" checksum="6320EAE9FC02264D" modified="2016-09-07" version="1">MFAKKWIGKGSSQKFCVELKTISIFQDNLQSELVQQLYKREVLEELLTESPVMAQRRKEAAEMLNALNKASNIIGEVRETQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5D9</accession>
    <name>A0A183H5D9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibroblast growth factor 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001609">
        <property type="protein sequence ID" value="VDO33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5D9"/>
    <dbReference type="STRING" id="387005.A0A183H5D9"/>
    <dbReference type="WBParaSite" id="OFLC_0000269801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000269801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000269801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23307">
        <property type="entry name" value="beta-trefoil_FGF8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000269801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21739" checksum="755A1D735AF9FE50" modified="2016-09-07" version="1">MASLMPIGEAITVWQLYSRCSSAFVQIFLKHANARGQQFNHCLTDFVVHADNEGRIRMENAFTGKFICFNKRQRLAIRSNGMDEKCLFREQLTPSGYTMFQSAWRQNLFLGFNRKGKFQDPSQFNTKRRCFLFTKLLREVKSTRLRSCSKSEKNDQIELDLEAKRQRYLYNVVRESLLSRIRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5J5</accession>
    <name>A0A183H5J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001660">
        <property type="protein sequence ID" value="VDO34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5J5"/>
    <dbReference type="WBParaSite" id="OFLC_0000275401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000275401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000275401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000275401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29124" checksum="36BDD1E0009AAF50" modified="2016-09-07" version="1">MGNAGNRAKKAVLISSLVLLLIALGISVVSVLSPSWQVVDIREFRAQHHHGLWQDCTRPHYHSYGISSEEYKEMQHTPLSCTYKFDHNAREIIDENLLDVSQNSAAGEAEHHQFFGWQKAVLVCFAVVFAVNGLALLCGICAPCSNPIAVFFTVLIFIACSLLLNYLLLVLFSIIGNATFFFAAHRVDSRFVHGLVGTYEQEIGSAFYLSLASTSLLLFSFLLALVSTYYLIQDANKPNNELISPVIRELVPLYNSTRHTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Y9</accession>
    <name>A0A183H6Y9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mucolipin extracytosolic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3250</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002114">
        <property type="protein sequence ID" value="VDO35815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Y9"/>
    <dbReference type="STRING" id="387005.A0A183H6Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0000325001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000325001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000325001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000325001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32377" checksum="6E8DF45E912F8734" modified="2016-09-07" version="1">MQQDILEPLSASDRSDGERLRRHLQFFFMDPITKWKVRHQFPFKLALQIFKIIFISIQLILFAELRMLHVDFMDETSTVIRHKFLKNWNDERDTLIYPPSSGRYSVYTGADIIDQFAFMIVAIDDPKFVGNISPDDIPPMKFCLKKIANVTIFNNTYEFDISEINDCVLLKFNEDEVKDIRRNASFLGQFLFKKYGITFEPKDSLIISKGVLSFNLRTIHFSTISTDERPECFLIQVSITFDNSRHTGQVYIYLSTVISYVTLCNGRVIHGMYQFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Z4</accession>
    <name>A0A183H6Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3256</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002122">
        <property type="protein sequence ID" value="VDO35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Z4"/>
    <dbReference type="STRING" id="387005.A0A183H6Z4"/>
    <dbReference type="WBParaSite" id="OFLC_0000325501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000325501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000325501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000325501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8449" checksum="4A389C5AC52869C3" modified="2016-09-07" version="1">MPGAPRFTQKPSIQQTPQGDLLMECYLEADPPPNIVWNHAGVPIVAGSRVELTLANLQSNLYKAILIIKVNLLLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7D8</accession>
    <name>A0A183H7D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFCD_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002259">
        <property type="protein sequence ID" value="VDO36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7D8"/>
    <dbReference type="STRING" id="387005.A0A183H7D8"/>
    <dbReference type="WBParaSite" id="OFLC_0000339901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000339901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000339901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000339901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20212" checksum="156500604D988FE4" modified="2016-09-07" version="1">MRGASDALLSVISDVRGSRQELEIFLQCLASILINNAGILRVTQPLLCTLEQILSAQLLECFEADPDSSPSLRKIVDRVAIVCFYFYNYLGFKNGSHEIYCLSVIRTLRSRYPVMRRNAAEQLYECLASECDSSNEAERNKRLELLNLLSKTKWNITGNEQYFVKVSHLVAEKLNVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H883</accession>
    <name>A0A183H883_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3696</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002566">
        <property type="protein sequence ID" value="VDO37468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H883"/>
    <dbReference type="STRING" id="387005.A0A183H883"/>
    <dbReference type="WBParaSite" id="OFLC_0000369401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000369401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000369401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="140"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO37468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000369401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="597" mass="69322" checksum="BDFBDEA9F88DE82F" modified="2016-09-07" version="1">MFILENLMNKLELGSSRAMCIYQQVLRMSDDFSSLEGLDFIEKRRIRAVSIISKLKDLFTIYWQYLDDKQKEYVTDLWVSLGFEKSKKSTAFPEGKLTLNMNMIYYQLAYGGEIIDIRSDPQKDDRVTGFHPDAWQRRMLDAVDKNHSAVIIAPTSAGKTFVSYYCIERVLRQSDDDMVVYVSPSKALLNQVCGSVYARFRNKTLSGGKSLFGTLLLDHSENPMNCQVLITIPECLENLLLSMNPIVQTMIDKIKYVIFDEVHCISASPDAHIWEHLLLLIKCPFLALSATIGNATVLHQWLQSAEKSKNIRGRPSREVELITYGERYSELELAVQRINSGFDTITRDGNDVDSMVEHFMPYGVYKPVKLLMFGIPADQQLTARQILDLYHALAEVDSVVKKEFEPCSFFKYKAEGEKVWLTREDIRRLEVALKNRFLEWLRINPERANKVLQQIGRNVENELNFRSRPFDQRATAVKSIAPLILELRDKELLPAICFNEDRRVCERLAQQLFDYLEMQQKEFEASPEYKKYEIKDEEKIAKMVKRKRDVAATKEKKKSKTADKFERAEMEEQEHNVQDDYDPIAAMRLRLNMVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8G8</accession>
    <name>A0A183H8G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S8_pro-domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3780</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002636">
        <property type="protein sequence ID" value="VDO37720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8G8"/>
    <dbReference type="STRING" id="387005.A0A183H8G8"/>
    <dbReference type="WBParaSite" id="OFLC_0000377901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000377901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000377901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF13">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552418" evidence="5">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8 pro-domain" evidence="7">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000377901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23613" checksum="7BB7245C406CECD7" modified="2016-09-07" version="1">MRRWHKWQLCSTYGILLFLICTSGNAVEIYTNHFYVHIKHPGIENAHSIAKRHGFINRGSVLGSATDWHFVQPALSHARTKRSFTHYKKLNDDHDEQLDFTAAQSPTDPLYPYQWYLNNIGQANGKPRLDLNVEKAWVLGITGKNITTAIMDDGVDYMHPDLANNFNARASYDFSSNDPFPYPRYTDDWFNSHGTRYHLIVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9A8</accession>
    <name>A0A183H9A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4069</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002949">
        <property type="protein sequence ID" value="VDO38758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9A8"/>
    <dbReference type="STRING" id="387005.A0A183H9A8"/>
    <dbReference type="WBParaSite" id="OFLC_0000406901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000406901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000406901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008332">
        <property type="term" value="F:low voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000120">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000008">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF230">
        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="91"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO38758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000406901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48427" checksum="86686634E336AAA1" modified="2016-09-07" version="1">MIYFISFLLLVGFFVLNMFVGVVVENFHKCKEALEAEMKEQARQKRLERKLKRQKYETEYGQKKKRREKSQPYWHSYGPTRLFLHNIVTSKYFDLAIAAVIGKLEARKDGGINVISMAMEFYMMPVGLKYVLKTLNYFFTAVFTLESAIKLVALGVRRFFSERWNQLDISIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIARVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSDEHPCDGLGEHAHFKNFGMAFLTLFRIATGDNWNGIMKDALRDDCDPSDRCESNCCVDPILAPCFFIIFVLISQFVLVNVVVAVLMKHLEESNKREEASDGHGIGGTDTDANKTDTDVEDNADSSQKDLDINGTDRKNEKGCLLVHGKYMETPLPKHNDHNGHSPMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9V5</accession>
    <name>A0A183H9V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4266</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003167">
        <property type="protein sequence ID" value="VDO39468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9V5"/>
    <dbReference type="STRING" id="387005.A0A183H9V5"/>
    <dbReference type="WBParaSite" id="OFLC_0000426601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000426601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000426601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="48"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO39468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000426601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32604" checksum="76F20030314357C2" modified="2016-09-07" version="1">IQIEELYGKQGHLFELEPDDEEVEFLLQRADENRDREDPEWLDDGIAMTLDSVTIAFPNDSSTPLVSNLSLQIVEGKNLLITGDGSVGKTSLLRVFAGLWKCVTGKLERHWKMSPTTLYFVPQKTYFPNSGCSLRQQLVYPLKALSLEKEAARLAQILEWVKLEHLLQRCNGLDTPVEWDWSETLSPGELQRLSIGRVLYHRPRIAFLDEATSAIGFEMEMSLYRLMKEERISYVSIGHRFSLKQYHDMELHLNGHGEWTLNGIDSTNISSSRTASFINLSMKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA08</accession>
    <name>A0A183HA08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U2 snRNP auxiliary factor large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4320</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003229">
        <property type="protein sequence ID" value="VDO39618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA08"/>
    <dbReference type="STRING" id="387005.A0A183HA08"/>
    <dbReference type="WBParaSite" id="OFLC_0000431901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000431901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000431901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="124"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="230"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO39618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000431901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43077" checksum="1CD65CD8DCF1CAA4" modified="2016-09-07" version="1">MTLNSDEKDKDKGKEKDKEGEKRDRRSRDRSRDKIEGLIFNDILIVCRRERRHHHRDRSRSRSRKERTPEKPKKKYKFWDVPPVGYEHLTPKEYKELQAAGQIPRNNVQSAVPVVGPSVTCQSRRLYVGNIPFGCSEDAMLDFFNQQMHLCGLAQAPGNPVLACQMNLDKNFAFIEFRSIDETTAGMAFDGINFMGQQLKIRRPRDYQPMSTSYDLGNMMVSNIVPDSPHKIFIGGLPSYLSAEQVKELLSSFGQLKAFNLVTEQSTGVSKGYAFAEYLDPSLTDQAIAGLNGMQLGDKNLVVQLSCANARNNVAQNTFPQIQVAGIDLSHGAGPPTEVLCLMNMVTEDELKDDEEYEGMFLNEEYEDILEDIREECAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA44</accession>
    <name>A0A183HA44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4357</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003268">
        <property type="protein sequence ID" value="VDO39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA44"/>
    <dbReference type="STRING" id="387005.A0A183HA44"/>
    <dbReference type="WBParaSite" id="OFLC_0000435501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000435501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000435501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF343">
        <property type="entry name" value="AMINO ACID TRANSPORTER SKAT-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000435501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18569" checksum="3FEF0E5CE4274B98" modified="2016-09-07" version="1">MSEDNGSVNDVRRLVQKETRKGDVISPHRAIMTLSKSMFNAGCFSLPYAWKLGGLWMSLILNFVIAGFNWYGDHILVRSSQHLAKKSERVSLDYGHFAKKVCDYSDIRILRNNSKIIMYIVNITILFYQLGMCSVAILFIANNMNHLLGDYIPGGVKVMALISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA45</accession>
    <name>A0A183HA45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4358</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003268">
        <property type="protein sequence ID" value="VDO39739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA45"/>
    <dbReference type="WBParaSite" id="OFLC_0000435601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000435601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000435601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000435601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7809" checksum="19CB3A1C07D56556" modified="2016-09-07" version="1">MRMPQVVRNLVFHLPFLFIGNRVLFSQRMVFEQNGSKSKSLYKKFQFSIESSQKAIFIKIIKWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBD1</accession>
    <name>A0A183HBD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pepsin-I3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4793</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003827">
        <property type="protein sequence ID" value="VDO41072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000479201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000479201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000479201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552467" evidence="2">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000479201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17161" checksum="64EFD8299CD9BB71" modified="2016-09-07" version="1">MQLFVVFFAAFTMQWCQIYSSGLTRAKHAFFDELNVLETYQPRARTMGYLFLPEPPTPVPDSQRHQQDTMKEAERTAFLQMRDAHYENEYTYMEKVNRELREEGNLVKQPQNEVQNDMTKTPKIEGPVLIEFHADTEKDDDEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBZ8</accession>
    <name>A0A183HBZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5010</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004100">
        <property type="protein sequence ID" value="VDO41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBZ8"/>
    <dbReference type="STRING" id="387005.A0A183HBZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000500901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000500901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000500901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000500901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28199" checksum="092C7DE91652FF1D" modified="2016-09-07" version="1">MAELDVVYQAAMREVERVQDILNEGLMGLNREQVDEMFDILENELRMAQHLAFWKSGVMFDVDTKLQNLIGRQTDPQQSKQQLTKPKGPRSKRQAPTARENIRRIESDTRSQSVVKVKGKDSPSPPAVSDQFLSGRRKKIKVPEMSEGRSIQKKRGAGRPRLPRKPRQAISAVTETVENENNLDPLYCLCRQVSYGDMILCENKRCNEWYHFPCVQLRQKPKGKWYCPHCRGDRCDMINPDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCC8</accession>
    <name>A0A183HCC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BBS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5139</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004268">
        <property type="protein sequence ID" value="VDO42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCC8"/>
    <dbReference type="STRING" id="387005.A0A183HCC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000513901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000513901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000513901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000513901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9470" checksum="B7A4634027E815F6" modified="2016-09-07" version="1">MRPIDPSTRMKKVYGISVNSEQNMFAVATEDGFRIFQCNPLHQVIRLDKRIVGSLRIGKVLGCSNFFGMVSGGFCPKYAENVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDD1</accession>
    <name>A0A183HDD1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS5492</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004751">
        <property type="protein sequence ID" value="VDO43334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDD1"/>
    <dbReference type="STRING" id="387005.A0A183HDD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000549201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000549201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000549201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="133"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO43334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000549201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35538" checksum="06B070E20F50DA5F" modified="2016-09-07" version="1">IFIGWKNLLLRAVHDEQQWGSQHQNNFRRQDDAILKFYYSNSRWAGLRDPLPERPLQWTEQLPRDELLESELFAGMNSGINFDKYEEIPVEATGQDCPPPIALFADLKLHPWIEENIRLSGYGRPTPVQKYSIPTLMNNRDLMSCAQTGSGKTAAFLVPLINNVLQAGPEALYKSTTQQNGRRRQYPAALILSPTRELSLQIYNESRKFAYRTPITSALLYGGRENYREQINKLRLGVHILIATPGRLIDVMEQGLIGLDGCRFLVLDEADRMLDMGFEPQIRQVCFMYILLLDAMHMTISIRLLRELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDI7</accession>
    <name>A0A183HDI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMPK1_CBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004826">
        <property type="protein sequence ID" value="VDO43503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDI7"/>
    <dbReference type="STRING" id="387005.A0A183HDI7"/>
    <dbReference type="WBParaSite" id="OFLC_0000554801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000554801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000554801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000554801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31811" checksum="51A7AFA2FAF3F920" modified="2016-09-07" version="1">METAVNEREAEIFAWKSSSLLWVCSSNQGHSHVVILDANNPNSVIDTFQACSAHVLCVSSVPGIQESDYPSEDTNWKKFCRGGGYMKDLPPDISEQEQFGAVQWIELRKLDSDEDTTSTYCGPDQKPSPQRSRDFSVCEQVAASTSENSQGLNEVTELVKMVNEVKDESETKKAENNGIVKKYILLEKLKEAADKGVTLEFFRKLADVHHCLCKLHVVIFRIPVFHHDLSRFKKFPDTLEHREKDDVGTLPVHIKNRLSKYEDLSDNMTALPTMWMGSQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE79</accession>
    <name>A0A183HE79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5791</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005169">
        <property type="protein sequence ID" value="VDO44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE79"/>
    <dbReference type="STRING" id="387005.A0A183HE79"/>
    <dbReference type="WBParaSite" id="OFLC_0000579001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000579001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000579001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008451">
        <property type="entry name" value="Chromadorea_ALT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05535">
        <property type="entry name" value="Chromadorea_ALT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000579001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36531" checksum="26E9A3429E913A2B" modified="2016-09-07" version="1">MATVNETTSATEKMITELTKIFPSWMPFMSDLEKSENLETKIKNLEIFGMNASASTDTKKVSKNAVSENIHPSMNASEVLESTQPSMNESAIPENPTTSTSKFETEAIKDNQEVLEADVEGLSTNPVSGNTHPSMSTSEAFDFKEPNNTHPSMNAPEIPENIHPSVNASEVLENTIPTISAIDTSAFKNNGKTIEEITTTLPEETTLKQTESTLSSTLKQTESTLSSTLKQTESTSFSTVNVAAQLPNSTRGRAVSSAIYEKTDGVPIQCQSNVDCLDLYEPEAWCALKSKQFWLGESCYCNELMKLCIIQVWKSEQLYFTDCSVGRQRNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEH0</accession>
    <name>A0A183HEH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial inner membrane protein OXA1L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5882</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005300">
        <property type="protein sequence ID" value="VDO44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEH0"/>
    <dbReference type="STRING" id="387005.A0A183HEH0"/>
    <dbReference type="WBParaSite" id="OFLC_0000588101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000588101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000588101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000588101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16584" checksum="64C10C7154EAC46D" modified="2016-09-07" version="1">MTDPNFMVPALSSILIGCTLFLGYDPTGTASASKYVKVFKYLLVPAGVFFFSSRVPVAISIYWCASNFFNLLLTTTLRIPKIRYALDIPLKVTKPSSVSFQKAWKRAFGWKKETEKQARSRPVLWEVMQRQDLERFAKAEQAVAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEQ6</accession>
    <name>A0A183HEQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5970</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005423">
        <property type="protein sequence ID" value="VDO44968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000596701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000596701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000596701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO44968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000596701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28952" checksum="52EF34DB0BBE93DA" modified="2016-09-07" version="1">MENNTQNNTEWEIIYRNRLDHGVVTYVFAIPIFQLAFIGLFAYGLSLYSICKSPRYHNAFGILCFAYVLFHIQTISALLIWTVVRIIANIGLISVPWRTFSRIFSPLANSSLYAAIWMQFVLAINRVWAISYPITYDRIFNLKNDRIIVVSIWLSSILITALYYNVECERYVEADFYSWSTLFGPCKHSFLTYVAVSLSDGIFLAILIVNTIAFYHIIAYFKKKKHQAARTQQRMGQEIVFFKEGTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEV6</accession>
    <name>A0A183HEV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005487">
        <property type="protein sequence ID" value="VDO45116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEV6"/>
    <dbReference type="STRING" id="387005.A0A183HEV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000601701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000601701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000601701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000601701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26388" checksum="F1DCED48AFB7A175" modified="2016-09-07" version="1">YALISYNIGINTVVEAIPHGNSKRNTTVYQRKEPSLIAEMKREKMKRLNERGSLEPEDAFVAVKQARLGSYVGAPSGVTLYEDSNYEEVEDAYPLTQEELMNRMALPSLRRFTRPYHNDEPFSVVFLLDQHVGIIQCASCGVDFSRQPQPPEDLVLEHVERFWNKRTCTYSTQQMQKKYIHARLECVLARYEYFTTLDFLVISDDVRLRLTNVHQQYLSIEFGCSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGB4</accession>
    <name>A0A183HGB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6526</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006247">
        <property type="protein sequence ID" value="VDO46823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGB4"/>
    <dbReference type="WBParaSite" id="OFLC_0000652501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000652501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000652501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000652501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36213" checksum="E61E34027BE6D24C" modified="2016-09-07" version="1">MSGWFTDVTCISHVLFFLVVVTVAFLNTVTGQLVQVSRRKENVTSPYLPKSLTSKPSVEQNKIRLRCGLYQQKLFCLITELCNKATTIVLLLSYFFYRTSFTIVLLLASYFFHTLFTSIIHITTSAQEMKILLGPDDVHCSQKCSKISSFELRNLQVLSSKTERIRKFSISKPLDTNLRINYYDVEMTGMSPAFCGNYSTFEMPTYSVKESKSKGFQFLHKLYFQSYRDVYTHSMCNSQCVFDCRQVGYDAEIMTELLLRNIPDLHVYQCDSVHSWVYILVMFIIFIILLMIIACCIRNKMSNIQGNTKETYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGN6</accession>
    <name>A0A183HGN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6648</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006445">
        <property type="protein sequence ID" value="VDO47305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGN6"/>
    <dbReference type="STRING" id="387005.A0A183HGN6"/>
    <dbReference type="WBParaSite" id="OFLC_0000664701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000664701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000664701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000664701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18892" checksum="8645BDAAF3A34F19" modified="2016-09-07" version="1">MSEKGIIALQKGDRLSLSSSSLAAIEEGLESSKDVTKSSFVLLCDSNTDGKVQLSPSTSKLIRTQLNTTLECRLLAKCLKDVAAKAINGDAPSVNRLLGCRSDSMSESEPEPVMNDASVMSSNCAERYIKKITEDMERIEKDLNSLRESFVEYYQKKIADELKEDESCRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI05</accession>
    <name>A0A183HI05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007207">
        <property type="protein sequence ID" value="VDO49399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI05"/>
    <dbReference type="STRING" id="387005.A0A183HI05"/>
    <dbReference type="WBParaSite" id="OFLC_0000711601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000711601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000711601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000711601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26560" checksum="DFDE736B3B936300" modified="2016-09-07" version="1">MNVLDTQITHIIFDLDGLLLDSETIYTQANTEVMKSYGKKYTMELKAKTTGMKMDDAIQTMLEHENLIGTVNLDEYKAKYLDLLGKYLPESRLLPGAMQLVKHFAKYKIPMAICSGSNLFEFDAKMKNQKELFDLIPLRVLTGDDPHVKKGKPEPDGFLETMRRFSVKPKSAAHILVFEDSINGVYAALAAGMHVVMVPDLRYSNPSETCKDKITLILNSLVEFKPEMFGLPPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI48</accession>
    <name>A0A183HI48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2281 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007288">
        <property type="protein sequence ID" value="VDO49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI48"/>
    <dbReference type="STRING" id="387005.A0A183HI48"/>
    <dbReference type="WBParaSite" id="OFLC_0000715901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000715901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000715901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000715901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11819" checksum="991F3F967D7DA951" modified="2016-09-07" version="1">MTRKLFVAVAMKKKLPSDAKCRFGKEFFAKLCELFQSTEQDSCDRLRHMHDELAAYYKEHDLNVMWISDDEADNKEVKAPLSKKTHQDVNKGGTRSINIPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIB6</accession>
    <name>A0A183HIB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007406">
        <property type="protein sequence ID" value="VDO49908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIB6"/>
    <dbReference type="STRING" id="387005.A0A183HIB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000722701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000722701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000722701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000722701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28965" checksum="7D3FB74AFB7C251D" modified="2016-09-07" version="1">MYDSIHISIVYVRLIFSPNHLFLTAGLYERLAELEEKRLTIVDEFNAEGTPDEQRERLLQTVIRTTDEINVIQKQLDDVNDQIEQLTEELREFDIEMENVAGNTVNCEKNEKYRELKLKEMQIDEFLNSYDSLRTEEELRVDEISTEVIRILELISTNITNFCLISQNTNLELTEFKINENISASALKELYIRLKEELVEMDKLEKHLKIDNNQISERIKGMNEEMTQFENIDDLKSHTEQKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ38</accession>
    <name>A0A183HJ38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7499</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007871">
        <property type="protein sequence ID" value="VDO51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ38"/>
    <dbReference type="STRING" id="387005.A0A183HJ38"/>
    <dbReference type="WBParaSite" id="OFLC_0000749901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000749901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000749901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF17">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000749901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15950" checksum="8B01DCA7C50EA291" modified="2016-09-07" version="1">MANGFGFAPSESNFIEPKKKPMSSMSPMIIYNTKTGEVVMVSGASGGSKIISVLAKSIVRVLFFNETIKEAIDAPALHNQFTPDITQFEDLVPKELMNDLTRVFGQNFKKTTGFEGIAQGIVVSEDGTIYANGDHRRETDMHPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJM0</accession>
    <name>A0A183HJM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7683</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008188">
        <property type="protein sequence ID" value="VDO52169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJM0"/>
    <dbReference type="STRING" id="387005.A0A183HJM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000768101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000768101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000768101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO52169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000768101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18607" checksum="A087DFEE3C484638" modified="2016-09-07" version="1">MAEMNDCASILESATCHSLVIVDELGRGTSTYDGFGLAWAIAEDIVSRVKCFCIYATHYHELTGLSPIYPKQLKNVCTASEIDENGQLILLYKVIPGVAVRSFGLNIGKMIGLPDNVLQVASDMLEKLEARNSKLSPDEEELYKKIHSLGDDELRRQLLDNVMNEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJX1</accession>
    <name>A0A183HJX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7783</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008347">
        <property type="protein sequence ID" value="VDO52493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJX1"/>
    <dbReference type="STRING" id="387005.A0A183HJX1"/>
    <dbReference type="WBParaSite" id="OFLC_0000778201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000778201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000778201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO52493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000778201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24842" checksum="8D0534D985AFD097" modified="2016-09-07" version="1">MSGGKRGEASERQKTEEEIAREEREKLIRQEKSRLAQMDQNGGNETKRKLSDGNKEEGFMVKYDSSGVLMNAEKLKKGRIKIVRIDSSDEDGSCSDEMDEGSEKDDFDAMVHGSGEVDLPPSSSKNIATNAETEVQKESENGVLPFVVDLPQKYENLKKLLDTQNDADCEIIIKRLIKLYHPSLREGNKSRLSRLFILLLRYYDDLSKERVSKIVLLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKA5</accession>
    <name>A0A183HKA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YKR034Cp-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7917</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008584">
        <property type="protein sequence ID" value="VDO53126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKA5"/>
    <dbReference type="STRING" id="387005.A0A183HKA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000791601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000791601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000791601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000791601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34750" checksum="9BC80156A4AB3A9A" modified="2016-09-07" version="1">MSAKIVIAVDVGSSDETNLYNYGDSLSGFWVLLKKLNPFAEPIKVLNMQEIQSRLAYVSCEQQRQLVKNAGYCQYIQPPIKDFKTLDFYKYDEIDNIGYKHGMKEFGELVTTNEDLKNVIDTEKLRSLKRRYWRREPSKLVMYDRNRASSFTNLAAQVSRVPKVFEKNLNDDEIVEDELSDVWWDENEEEEEQEPDVQSQPAYHSEDVESIEAGYISEPCTTYQSKYAFSSEDEISTDKDNAENSRKRKNTLSEINRNCEYKTEMQEKSEKTSVVRFGLLESPRGDNSEESRDMTLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL54</accession>
    <name>A0A183HL54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RPN13_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS8215</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009119">
        <property type="protein sequence ID" value="VDO54604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL54"/>
    <dbReference type="STRING" id="387005.A0A183HL54"/>
    <dbReference type="WBParaSite" id="OFLC_0000821501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000821501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000821501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO54604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000821501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8266" checksum="55E3E716A79DAA38" modified="2016-09-07" version="1">MCGQPSQLIQIFQQTLPSEHFALLVQKLPEAKARLMRMFGGQLGQIERSHAGAEDGDNSAVVGANTIEISDDLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL64</accession>
    <name>A0A183HL64_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8227</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009140">
        <property type="protein sequence ID" value="VDO54662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL64"/>
    <dbReference type="STRING" id="387005.A0A183HL64"/>
    <dbReference type="WBParaSite" id="OFLC_0000822501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000822501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000822501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO54662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000822501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13450" checksum="E7CC2FD17F7B32FF" modified="2016-09-07" version="1">MSLKERLSYGAKVLVTGTPLMNAERFTINFLTQTEHFFHFRVDFSVGNQKEAVVRNSTKNGEWQKEEREMCSFPFRRGITFDIMFCFEEYITVSLLYFAFGFVEAVEIIIYDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLN9</accession>
    <name>A0A183HLN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009463">
        <property type="protein sequence ID" value="VDO55497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLN9"/>
    <dbReference type="STRING" id="387005.A0A183HLN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000840001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000840001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000840001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000840001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7951" checksum="BFE6505C3A3D7E8F" modified="2016-09-07" version="1">MFRWGILQEAVQRLSFVSTSTGYSSARSSLRSSEISDDTVHPVNTSTGKKLLTFVSIYAIFKFIILVTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNV7</accession>
    <name>A0A183HNV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FrhB_FdhB_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9167</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010966">
        <property type="protein sequence ID" value="VDO59000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNV7"/>
    <dbReference type="STRING" id="387005.A0A183HNV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000916801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000916801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000916801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000916801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13166" checksum="941275E97BE6B8EB" modified="2016-09-07" version="1">MLIELLSSTLPWKGMARKDSFQTKKTVSDRVLLAGCPDCFADVNNYLKSLTYLDTPNYAMIRAKFTKELQKLKIRPSDPFEWNEKILSKQEIFPSGEHDKDIKVEIDKRKIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP17</accession>
    <name>A0A183HP17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011104">
        <property type="protein sequence ID" value="VDO59266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP17"/>
    <dbReference type="STRING" id="387005.A0A183HP17"/>
    <dbReference type="WBParaSite" id="OFLC_0000922801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000922801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000922801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000922801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17133" checksum="D87D95B4A70F7AA2" modified="2016-09-07" version="1">MFLNDQNNGLEMLIDYLTQLQEDGSWGNICNDSNQDGASSSGAFPYSHASQSHTLAVPNSGENDHFSDEKITGGLFRRTTSVTKKSSKNHGDRDDDIHKSFLMYEAELIFIYTRLPLQYGFNMVFSNPQAIYCIARSILHQSLRFAFYNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP26</accession>
    <name>A0A183HP26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin_14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9238</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011127">
        <property type="protein sequence ID" value="VDO59317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP26"/>
    <dbReference type="STRING" id="387005.A0A183HP26"/>
    <dbReference type="WBParaSite" id="OFLC_0000923701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000923701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000923701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000923701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11469" checksum="4813DB7F9662B871" modified="2016-09-07" version="1">MDDLPVLAVDSFRHMYLFPDMKSLTVPGKLRQFILDLNSGKLHREFHHGPDPTQAPSSPTTSEVVFEKEAKGTDKSQPPTSVFKQLKPSESRYSLLKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP60</accession>
    <name>A0A183HP60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9272</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011208">
        <property type="protein sequence ID" value="VDO59473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP60"/>
    <dbReference type="STRING" id="387005.A0A183HP60"/>
    <dbReference type="WBParaSite" id="OFLC_0000927101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000927101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000927101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000927101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14435" checksum="DCF57CF8835B0465" modified="2016-09-07" version="1">MIVALYLPSLSTIRNLVTSFKNMGVKYLEIKGNQKGELQFCGDLDMANIVVHFSNLSVVSLQNDDVNDVNDPGVLQIVRIDIRAVHLFLRSFSSLFTASRILLSIVPEKMAIFSLEQNEASLLYIVSGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPA6</accession>
    <name>A0A183HPA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9321</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011305">
        <property type="protein sequence ID" value="VDO59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPA6"/>
    <dbReference type="STRING" id="387005.A0A183HPA6"/>
    <dbReference type="WBParaSite" id="OFLC_0000931701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000931701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000931701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000931701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14774" checksum="44C9CABB2E52E2F7" modified="2016-09-07" version="1">MFPQFDITTIVEFLRETGSVQAAVENILDSRLQQNIESDEDVWNAEETSLSSNSSTESSSEYEEALQPLESSKPDSVERHDILSQKRDALIQLHRKRYIESSRGADLRNIYGEDIPDTRNPDSLKQKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQI5</accession>
    <name>A0A183HQI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxin-13_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9749</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012300">
        <property type="protein sequence ID" value="VDO62964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQI5"/>
    <dbReference type="STRING" id="387005.A0A183HQI5"/>
    <dbReference type="WBParaSite" id="OFLC_0000974601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000974601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000974601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin 13 N-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000974601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15153" checksum="DAAABD74CFB8DA2C" modified="2016-09-07" version="1">MNYRHSWTDRPVPPRMGPFTCPHTIDHPIISMPQVQSSTPTHTRCTYCTNLRSCTTDGKITQFFNKSTRGTFDSIEAILTAVNSIADMLNATHHAVFSSFQAVLGALDEFAKLKTQVCKVIIFIFSLKKFHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQQ7</accession>
    <name>A0A183HQQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9819</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012476">
        <property type="protein sequence ID" value="VDO63627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQQ7"/>
    <dbReference type="STRING" id="387005.A0A183HQQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000981801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000981801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000981801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056241">
        <property type="entry name" value="LTN1_HEAT_5th"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24618">
        <property type="entry name" value="LTN1_E3_ligase_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin HEAT-repeats region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000981801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23896" checksum="10421DFE1A10632B" modified="2016-09-07" version="1">MDAQECLASPVVTSLLSENVDNNSTLLPHLIYASFIINYLDMTDEANIGHYTTSLLYAVAISALASINTICNEQFIDAKTNLNNLVNQMILTNEQFKEDLLSECISLIADGNQSLCLLVALRLLADGLCMEKIEAVFKVSGKNLDSFGIILCSAALRYQGKMYEGYCDPPVSMKHWISHFEMASSLKEPGNLLQLLSQFVVEGRSTLEEYIFTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR96</accession>
    <name>A0A183HR96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10009</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012887">
        <property type="protein sequence ID" value="VDO65099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR96"/>
    <dbReference type="WBParaSite" id="OFLC_0001000701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001000701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001000701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001000701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4533" checksum="10685F91181872E3" modified="2016-09-07" version="1">MQIRGVVLVFYINNKVNQWMLCRLIDFFNLYLEVILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRQ7</accession>
    <name>A0A183HRQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10165</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013270">
        <property type="protein sequence ID" value="VDO66341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRQ7"/>
    <dbReference type="STRING" id="387005.A0A183HRQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001016801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001016801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001016801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001016801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10955" checksum="68B6ABC7D14C3B51" modified="2016-09-07" version="1">MSSTQYGIHPDCDGGNNSSGSSGGLLNTFKATKKFFKKIYDTATLPGRANSKILVSNATEQDEIPTTSLSLQQSFIDASYSLELPDDEQSYQDNHDNANQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRR8</accession>
    <name>A0A183HRR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10183</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013305">
        <property type="protein sequence ID" value="VDO66491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRR8"/>
    <dbReference type="STRING" id="387005.A0A183HRR8"/>
    <dbReference type="WBParaSite" id="OFLC_0001017901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001017901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001017901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO66491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001017901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17578" checksum="683DF4133958CA86" modified="2016-09-07" version="1">MENVDAGSIGRDGEKALRETGETGLIEAVEWIAEHQKNNDTSALKPTEMQLPEEERSIVEFAEEEEPSKSSSTEAPQSMSFKCDVCGKQLVDDQAVMFHAARTKHEAFSESTEVLKPLTEEEKKERLAALQKRLKEARAKKEEEERKEILEKVGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS20</accession>
    <name>A0A183HS20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013528">
        <property type="protein sequence ID" value="VDO67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS20"/>
    <dbReference type="STRING" id="387005.A0A183HS20"/>
    <dbReference type="WBParaSite" id="OFLC_0001028101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001028101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001028101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001028101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12854" checksum="083F977F2343D434" modified="2016-09-07" version="1">MGASNLALIFAPCILRTNQAMRAQDQLRDVERQAICVQTLIEEKLRQFHSTLTEIVTLETASEKIVENLRLIDEHRDSTEKEMQTPNEKLETARQLFMEQLEFLDSEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSH0</accession>
    <name>A0A183HSH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10436</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013902">
        <property type="protein sequence ID" value="VDO68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSH0"/>
    <dbReference type="STRING" id="387005.A0A183HSH0"/>
    <dbReference type="WBParaSite" id="OFLC_0001043101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16572" checksum="E9C4044896014E0D" modified="2016-09-07" version="1">INEAKENVIASLAAGCGEVPLLAFILIEQVNSLRDYLLKLCMQSTIDTNDIHRLLRLAIKLNVPSIISSTDLTTLCTNMDINDLFEEALLSDNRLIVLAAILKQNIPIKISLHLLTKLMRHASDQVINFRNNPNFDRTMPEFSPKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSZ3</accession>
    <name>A0A183HSZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sld5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10603</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014315">
        <property type="protein sequence ID" value="VDO69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSZ3"/>
    <dbReference type="STRING" id="387005.A0A183HSZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001060501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001060501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001060501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001060501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22100" checksum="D37E4D7FCB936A62" modified="2016-09-07" version="1">MTKQRLIDMGISLDLVCLGEQPLHTVPLFVFQRTSIYPSEDYLIPHWMNYSYYQMSRRSAISIKFKPRINLPDELLRNARRGLVMETNGSLINDFDAADEKAFSSLIDNSSMSANLASEFAKEFPLKKNLNCGDTMVVCIPIFFLYFLFYLILTLSKFSLQIRMKYEIKSLMYFFFLLVSQQRFLFVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT45</accession>
    <name>A0A183HT45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014429">
        <property type="protein sequence ID" value="VDO70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT45"/>
    <dbReference type="STRING" id="387005.A0A183HT45"/>
    <dbReference type="WBParaSite" id="OFLC_0001065701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001065701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001065701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF5">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001065701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22393" checksum="C68637FBCB78618A" modified="2016-09-07" version="1">MQYIIYTSPALRCVQTAHSALKAMSKENEIKIRIEPALFEFTDLHPGQPKFATPEEFFEANFNIDIDYVPITTMDDIWKRNETVEMYSKRVQNLLQKLAKTHEWSKRSDGALILVVGHASTVDLAIGAFREPPRTLLARELINQGAKFPYCCTAIIDRTDDGRWLYNENALPPITYMNFSSKINRDFAMRERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU15</accession>
    <name>A0A183HU15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10972</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015262">
        <property type="protein sequence ID" value="VDO72790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU15"/>
    <dbReference type="WBParaSite" id="OFLC_0001097701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001097701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001097701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001097701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12137" checksum="29AEC8CE75DF51D0" modified="2016-09-07" version="1">SSVRNFFQIIRVIAIGHIFSKLSNDTPKHRSSLVALHFINRTKTSVVSQIIVVCCVYLRLLNSCNLVIVFLYRQRDLRHAAVRCIKNQFFGRKNHVQSIKICPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUK7</accession>
    <name>A0A183HUK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015789">
        <property type="protein sequence ID" value="VDO74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUK7"/>
    <dbReference type="STRING" id="387005.A0A183HUK7"/>
    <dbReference type="WBParaSite" id="OFLC_0001116901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001116901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001116901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="1">
        <location>
            <begin position="32"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001116901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26800" checksum="46A66F30718E5211" modified="2016-09-07" version="1">RSCEKNFFFFTLTEITDCSKFQISIKNFNIITNFQVNQLPWNEQYDGIRAETSLIKDQLLWCNSNGFLTINSQPSVNGAPSTDPFVGWGKPGGYCYQKAYLEFFTSQANAEILWNLLPSYSRLNCHIVNHDATIDWTNTETTMPIAVTWGVFPGSEIAQPTVVDPLSFRVWKDEAFGAWLNWSSIYAEGTSSRCLLEKIYNEYCLVTLVDNDYPKSTIIFDCLAQLVNKNFGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUT3</accession>
    <name>A0A183HUT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS11245</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KCTD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016003">
        <property type="protein sequence ID" value="VDO75048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUT3"/>
    <dbReference type="STRING" id="387005.A0A183HUT3"/>
    <dbReference type="WBParaSite" id="OFLC_0001124501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001124501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001124501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO75048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001124501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15161" checksum="9328434EF1F2868D" modified="2016-09-07" version="1">MVEQIINLNVGGHRFATSRQTLTWIPNTFFTSLLNGRIPTVRDETDAIFIDRDPEIFRIILNYLRTKQISLSGVSLINLKHEAQYYALGPLVKRLTLCEELDECACGDVLFNAYLPPPALPLNEGMFFIVKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUX4</accession>
    <name>A0A183HUX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11286</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016126">
        <property type="protein sequence ID" value="VDO75343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUX4"/>
    <dbReference type="STRING" id="387005.A0A183HUX4"/>
    <dbReference type="WBParaSite" id="OFLC_0001128601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001128601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001128601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001128601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12770" checksum="C33563827443A5CB" modified="2016-09-07" version="1">MICQDAIRAEFLNRIPPYIAYALKIRVTEWNMEGEVLQIVAEVECKKDRIGRIVVGEHGSTIVAVAKEVNESMQNLLAQQLFLRILVKVEGKLFDILQYNARRNVTKKSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVA4</accession>
    <name>A0A183HVA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GN3L_Grn1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11421</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016471">
        <property type="protein sequence ID" value="VDO76303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVA4"/>
    <dbReference type="STRING" id="387005.A0A183HVA4"/>
    <dbReference type="WBParaSite" id="OFLC_0001141601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001141601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001141601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO76303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001141601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16418" checksum="0D972992D0DB6A0C" modified="2016-09-07" version="1">MEFYRLEAKVWKAKNKPINVPNKCPFKEEILLQAEKERERIEDEKCKKKTMKQKCPDVVKIGTKRKCISDDLQTLAMKASEQVKGISERFENRNVENLEEIQEKKQKQYANEVRKTVESADIIIEVCYVDGVCNVKQCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW84</accession>
    <name>A0A183HW84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017398">
        <property type="protein sequence ID" value="VDO78893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW84"/>
    <dbReference type="WBParaSite" id="OFLC_0001174601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001174601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001174601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001174601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5419" checksum="AD50D2B3CB895FCD" modified="2016-09-07" version="1">MQRIKSFGQKMVKKLQTMHILKYHQMVLYVFFTHVWKMLAYTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWC4</accession>
    <name>A0A183HWC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017494">
        <property type="protein sequence ID" value="VDO79192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWC4"/>
    <dbReference type="STRING" id="387005.A0A183HWC4"/>
    <dbReference type="WBParaSite" id="OFLC_0001178601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001178601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001178601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001178601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9576" checksum="B74451B118FA115E" modified="2016-09-07" version="1">MERTNENSQRSPGSTQQRIVQVTLHEPAYLHCTIPHLRQNMVAWTRLRDEALLTVGENSFTTDSRFQISHKPSEADWMLIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWW9</accession>
    <name>A0A183HWW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017979">
        <property type="protein sequence ID" value="VDO80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWW9"/>
    <dbReference type="STRING" id="387005.A0A183HWW9"/>
    <dbReference type="WBParaSite" id="OFLC_0001198101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001198101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001198101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001198101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17233" checksum="CB33A49A52F1CDDA" modified="2016-09-07" version="1">IPLFSIYLYFFFQTNDLNCLNGVRRLSLNKCLIDNWSSIEHLADINTLQDLRIIAIPLWKEYTNDEHFHLIVGRIPQLKILNGSVISAEQREQSERFLIRYYDVREIKPKIFTRLVKRHGHVEQLCKVDMTPKKYAVIVVICEETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWX8</accession>
    <name>A0A183HWX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11989</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018007">
        <property type="protein sequence ID" value="VDO80933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWX8"/>
    <dbReference type="WBParaSite" id="OFLC_0001199001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001199001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001199001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001199001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4828" checksum="F9A3A880027A3CF6" modified="2016-09-07" version="1">MQVMKLLMVMNNFMNHYFHLLMLNVNVKLKIVMYLVWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYX2</accession>
    <name>A0A183HYX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12684</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039903">
        <property type="protein sequence ID" value="VDP11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYX2"/>
    <dbReference type="WBParaSite" id="OFLC_0001268501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001268501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001268501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001268501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36339" checksum="24CD2330AD957A1A" modified="2016-09-07" version="1">EETTVGKELDDIEDSVTEPLTRFSVVTFIQTDVSNDTRLIPPANSSNLQNIAFPVLSNNEENGKRILSNNTEASEQDKDDNKKDEEDNGLNSNAIDEELEIRRKMKRTTVEVRSYPPVTETSPSPAATNIPSLDLDHTTTLAIPATAISLPSIPSTPDYSSVPHDLDFGPRTTVSYASLSPTLPSDVAQDHHNRFNEVIQRINVTELSTIPSFINVAVPFALPIPLGKGETPLNLFDTQLQNSGISALINNGHFWTADRLDAARKNDALKLQEKIQGQMQLHTPVDDVLGCTWDIVTSSCKDLFSLKLCSHCHDFGNIFLHNCKCLVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZG3</accession>
    <name>A0A183HZG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12875</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039961">
        <property type="protein sequence ID" value="VDP12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZG3"/>
    <dbReference type="WBParaSite" id="OFLC_0001287601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001287601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001287601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001287601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7679" checksum="2BB32499D7C5C61A" modified="2016-09-07" version="1">MPTKLSKLGLHGVPEKEKRCVFSSLHSSRIDASKINPQLQLLAISQHPHLPNSLSGGGLTWCQEIYDDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0J8</accession>
    <name>A0A183I0J8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13260</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01040114">
        <property type="protein sequence ID" value="VDP13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0J8"/>
    <dbReference type="STRING" id="387005.A0A183I0J8"/>
    <dbReference type="WBParaSite" id="OFLC_0001326101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001326101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001326101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552717" description="Branched-chain-amino-acid aminotransferase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001326101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25953" checksum="5015D57E32670A06" modified="2016-09-07" version="1">MPTLGLSVAKQALLFVLTGPVGQYYSTGFKPISLYADPACCRAFPGGVGQYKMGCNYAPTLLLSNIAASKNCQQVLWLFGEKQWITEVGSMNIFIYWENEQGDNELITAPLYDGLILPGITRESVLHLARQMHDIKVTERYVQMGEVRRAIKEGRMYEMFGTGTACVVSPVERILYKDPSTGDFEEMVIPTITHKPNLMQKLYQTVVDIQYGKMKMPEWITEVTSLSRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Q2</accession>
    <name>A0A183I0Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem II protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040140">
        <property type="protein sequence ID" value="VDP13429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Q2"/>
    <dbReference type="WBParaSite" id="OFLC_0001331501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001331501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001331501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001331501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4373" checksum="9291FF049D28CEA1" modified="2016-09-07" version="1">MGHVRSVKMSSFVFPSMSGRFLGFYRWVTSFWIIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I107</accession>
    <name>A0A183I107_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitroreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13419</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040189">
        <property type="protein sequence ID" value="VDP13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I107"/>
    <dbReference type="STRING" id="387005.A0A183I107"/>
    <dbReference type="WBParaSite" id="OFLC_0001342001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001342001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001342001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140616">
        <property type="term" value="F:iodotyrosine deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001342001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35661" checksum="8F6BB973DD322798" modified="2016-09-07" version="1">MTLQMMTEDNWRWDIVHACINILCLTFVIAFVVVQLVSLLRKDDIRKRSMTIMQPARKFTPQTRMTDKQIGDVIESVVNYREVFAIKKVPYHRLRLHDDEALLRSQLFYENMKMRRCVQEFSPRPVPSKLIQNIIKSAGTAPSAGNLQPWMFCVVSSYELKAEIRKIVEEEERNTYSKKMGADWVLDIAELKIIWSKPYLTDAPHLIVVMKQVEFAIYLINDSNELTSTYYNQISIGIAVGILITALQDAGLATSITYPLYGGEKIRKYLKRPLHEEVFLLLPVGFPAKNATVPNLKRKSVEEIIRCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I148</accession>
    <name>A0A183I148_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COE1_DBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13460</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COE family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040211">
        <property type="protein sequence ID" value="VDP13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I148"/>
    <dbReference type="STRING" id="387005.A0A183I148"/>
    <dbReference type="WBParaSite" id="OFLC_0001346101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001346101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001346101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000004">
        <property type="entry name" value="Transcription factor COE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor COE DNA-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001346101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20960" checksum="E6FFEDE9BC08B80A" modified="2016-09-07" version="1">MKDEPLGAALRTQWNPAAAAAAAAAATMVDSSPFSTTPCFSAQLARAHFEKHPPNNLRKSNFFHFVIALYDRAGQPVEIERTQFADFVEKEREVDGQDTRNGIHYRLWLAYANGLRAEQDLYVRLVDSVSKQAIAYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRTVNYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I197</accession>
    <name>A0A183I197_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040236">
        <property type="protein sequence ID" value="VDP13939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I197"/>
    <dbReference type="WBParaSite" id="OFLC_0001351001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001351001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001351001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001351001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37338" checksum="931DC6D29EA700AC" modified="2016-09-07" version="1">MGMGEKILFRLRIMQLKLFLKKHSFCWWAVDIVATSKNPELYYNGDSPMIENNINRVCNAEKHSRYGISYVDVLLSRRGIIDILAEVSYYCCKDCTRFENYTKEKKIEDLLDHYYEKRLEPLLDTDRYCFNIDGEKENSLTSLFFIDNGCNNISTIEKDVKCWQVPSEYFVFCCCWNNPLNCTYSPNTELITEKNKKIWLKLAKTRNPKSTLEMESIIFGNRLIDWPYRDFIYSLPSESEGTYTIPGLNEPRYHCLQVYFSADRMSSYDWIIIKPEKIQSRYRFCKVATTVSFKNNTRQRFVRVYNNYAVPNCVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1E0</accession>
    <name>A0A183I1E0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13552</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01040261">
        <property type="protein sequence ID" value="VDP14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1E0"/>
    <dbReference type="STRING" id="387005.A0A183I1E0"/>
    <dbReference type="WBParaSite" id="OFLC_0001355301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001355301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001355301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001355301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27035" checksum="E9F14AEFBBCE913D" modified="2016-09-07" version="1">MADNALEKQEMFKRSCFITQLVALSTNVAERAGSIIKEWAFNGTGKSYYKGPVSLRDLYTDADIAAEDCIISSLRKHFGDTLKIIGEENIAPMGTSVINDFDPNVLIYDDECSDEVRQITSDEVVIWVDPLDGTYELVAAEGNISRQQEVTVLIGVSYQGRPIAGIIHQPFWGTDAIGRTIWAIKGVGVHDNSQRYAVTTRSHSTPYIRDTLNILREKNLISDVEFVGGAGFKVCYSFSNVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1U3</accession>
    <name>A0A183I1U3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS13705</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01040349">
        <property type="protein sequence ID" value="VDP14455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1U3"/>
    <dbReference type="STRING" id="387005.A0A183I1U3"/>
    <dbReference type="WBParaSite" id="OFLC_0001370601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001370601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001370601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP14455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001370601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8255" checksum="EA8E81F896405E3C" modified="2016-09-07" version="1">IISAAGILLGIPTPAFSTALAFYDGFRCEVLPANLIQAQRDYFGAHMYELMNKPGRFLHTNWTGTGGNVTSTAYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I216</accession>
    <name>A0A183I216_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13778</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040389">
        <property type="protein sequence ID" value="VDP14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I216"/>
    <dbReference type="WBParaSite" id="OFLC_0001377901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001377901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001377901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001377901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11949" checksum="CA528DE0A62BFA9B" modified="2016-09-07" version="1">MCVGGASAPSRLPYVRPLFAGSSPILVTCKWHERQINDVYEQSRQGAKELPRRLRTDISKKTDRQTDGRNRRQIDRRSVRLSAGGYQSVRWFWADLNAHSFGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I297</accession>
    <name>A0A183I297_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13859</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040436">
        <property type="protein sequence ID" value="VDP14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I297"/>
    <dbReference type="STRING" id="387005.A0A183I297"/>
    <dbReference type="WBParaSite" id="OFLC_0001386001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001386001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001386001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001386001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29509" checksum="21EF646FD467AB82" modified="2016-09-07" version="1">MSETTKLKEPMRTENRIHPYNFITIRKKQRQNIEGLAGDKRFEQKKKAEQTDTIGESLKEKWETPDVLLGIKMIAELVNFNLVKSKESGWIVMDAEKQKDIVYSWAVEIHNKKVQEYPRTFKYQDAYFKNLAQEGVIEKIDIIHYDSEIFTTKTTEGPSLNECLYRGPVMLSSLVGIILRAKQSRYIIMADVEKAFLQVGLHKEDRYVTRFLWLEDTRKETIPEDIVIYRFKRVLFWNNIFPIFTLTIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Q5</accession>
    <name>A0A183I2Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin-11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14017</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040538">
        <property type="protein sequence ID" value="VDP15278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Q5"/>
    <dbReference type="STRING" id="387005.A0A183I2Q5"/>
    <dbReference type="WBParaSite" id="OFLC_0001401801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001401801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001401801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="125"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP15278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001401801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29435" checksum="F6035F9707281187" modified="2016-09-07" version="1">MCHRLSGDDHDGAPPYAFIFRGPEVSPMFAEKSNSRSESFDKPEARSEWSNGWHNVQKGIVADPALQAEWAKKRLVWVPHETEGFVSGSVKEDRGDDAVVELVDNGKRLTLSKDDLQKMNPPKFDKVEDMAELTCLNEASVLHNLRERYFSSLIYTYSGLFCVVVNPYKKLPIYSETLIEAFKGKKRHEMPPHIFAIADTAYRSMLQEREDQSILCTGESGAGKTENTKKVIQYLAYVAGATRQGKSNSPLKVSFLYFMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I366</accession>
    <name>A0A183I366_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14180</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040647">
        <property type="protein sequence ID" value="VDP15800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I366"/>
    <dbReference type="STRING" id="387005.A0A183I366"/>
    <dbReference type="WBParaSite" id="OFLC_0001418601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001418601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001418601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP15800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001418601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43461" checksum="AB740FBF8AFE2ABF" modified="2016-09-07" version="1">MHYRFCPESNVRILCPSRCTVDSTQKCLPWQFDCHFGIPRCISQFRVNDGAIDCISGFDEGCPPHNFVCADKSACIDFSKYQDGIPHCKDKSDEPCPAGDFLCNDHSKCIEGRRFQDGIADCRDGSDEECTVTQFECSCGKIRCVDGETLKDGKKDCEDGSDETGPSKKKLCPDGSPVRQSRAKNRTVLYPTYSAITQCPDPSVCNDELGEICIMVGGATHCVCKKGTIRPHGSPRCVLEPLLQQYLNNIIGNCTEIQKDLIEVYGEKVSFSHDSSRTYARKEMECDPDSKTPCKGYGEVCLSDASGRHRCTCANNGTRTNGICLVNECSRPELNDCDPNASCMDSVLSYECFCNEGFIDTSMSPKTRPGIKCAKCLFTIVVIHYQFSVFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I400</accession>
    <name>A0A183I400_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14462</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040876">
        <property type="protein sequence ID" value="VDP17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I400"/>
    <dbReference type="STRING" id="387005.A0A183I400"/>
    <dbReference type="WBParaSite" id="OFLC_0001447001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001447001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001447001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001447001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41026" checksum="6055C75479029EC6" modified="2016-09-07" version="1">MESVELVLESVENDYPGLVREALAAKEPNNSCSASLSSCGYAWLIVGHNLYVWKYDAEDGYACAPAVLNLPPSGLPYNAQTVCVYKKQGFSTFGIVAVTPEGVFRHWSMPDRQFSDSSVDLDREVVLSLTRINLHSSDGIYFLLATTTCSLFLLNVNANITPTPGKRQRLSSEITVKIIHTNARTGIGGKLASAIFGEGRQSGSRLIKALVYEQSNDELVGSNFITSSSSNSISGKNMHVLAVTEYHLHSYSIRDSAKIWSCELAEMAGEHFALDLWNLHDIEKHNHWREKIETWILDVVNIRNGALILFACCNKVISTQIHFAFGYISEYDGSHPPIALEWFCILKALSNEYKVNQQIFSIYFNKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4R6</accession>
    <name>A0A183I4R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein with serine-rich domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14728</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041132">
        <property type="protein sequence ID" value="VDP18446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4R6"/>
    <dbReference type="WBParaSite" id="OFLC_0001473901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001473901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001473901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001473901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13609" checksum="7559D54A6C1ADCAF" modified="2016-09-07" version="1">MLDYQKYTTRSESAPARSASRSRSGTPIASGKSNGHARSPSGSRLRSSSHHSLSQSPVRERSAASRSSGGHEASRSPSRARSRSRDDRRVRRSRSPEERKRYRSRSRDSRYRRRRYCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I628</accession>
    <name>A0A183I628_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Laminin IV type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15190</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041741">
        <property type="protein sequence ID" value="VDP20773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I628"/>
    <dbReference type="STRING" id="387005.A0A183I628"/>
    <dbReference type="WBParaSite" id="OFLC_0001520101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001520101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001520101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin IV type A" evidence="5">
        <location>
            <begin position="103"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP20773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001520101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21870" checksum="E4551646345D18A3" modified="2016-09-07" version="1">CAPGYERSPQGPYLGTCVPAQPRIQCSSAGARSAHPGYDGRCQCKMYTTGPLCDRCPPNTFHLAPRNPQGCIPCFCSGVTQQCSSASNYYRSQVIIDYGRGANDQLEITTSDAHNPFMPQSQAQITGRDITFSSFHEVPGQTLYWKMPKQFLGNKVTSYGGKLKYIFRYSGNGPLNMDPDVILRVCYPFFGYIFLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I640</accession>
    <name>A0A183I640_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BEACH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15202</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041756">
        <property type="protein sequence ID" value="VDP20823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I640"/>
    <dbReference type="STRING" id="387005.A0A183I640"/>
    <dbReference type="WBParaSite" id="OFLC_0001521301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001521301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001521301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP20823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001521301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42253" checksum="5B97D2D85EB1E25D" modified="2016-09-07" version="1">MILTVTYRVNTMSDRKEESDELSTSALRAMIKTYGQMPLQLFHSPHLPILCSKGYQNTLNISSSPLDTVKGIRWGEFVGSPVTEFGKLTIVLNQKLVCNNDYAGRLIAFSDGTCFAFPSNTCFIYKYGEAVRSRDLCSYGLVTWRHSDGILRLRLHEPKLWWDLANYHTYSVVSAAYCVSFNLLFVGLSCGIVLVYRILLSEFGVKDFALLKTLYAHDAAVRALAICGDFAIAASGCDMGKICIWDLNRLSHVRTLVPGNGKEVQFICISRTSCDVAIVAYSGYGSNITLKTINGLEIGSIDTDVVVTAVAMTSLSEGTAVNCLFLGMQNGVIKIFDMWTMRFVRDIVDYQFLEPIVRLLKQLFVKICANLIDDHATTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6B6</accession>
    <name>A0A183I6B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15277</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041868">
        <property type="protein sequence ID" value="VDP21124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6B6"/>
    <dbReference type="STRING" id="387005.A0A183I6B6"/>
    <dbReference type="WBParaSite" id="OFLC_0001528901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001528901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001528901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001528901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15944" checksum="B03387D7E747E0E9" modified="2016-09-07" version="1">MKILGSWFYVSQYSRALKANLLTLPSTSRSSDNDLVTLSRRGQLLPNGVSALLTAIESELPTHLNLYLRLIAASRRPPTRQRLVAATVLTANRPPNLVEADLRECEPILECIDPLILSGAWHERFMGDECEEGHALWAQFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I778</accession>
    <name>A0A183I778_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-tubulin complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042419">
        <property type="protein sequence ID" value="VDP22736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I778"/>
    <dbReference type="STRING" id="387005.A0A183I778"/>
    <dbReference type="WBParaSite" id="OFLC_0001560301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001560301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001560301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001560301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15684" checksum="A1DB1726772CDE78" modified="2016-09-07" version="1">MANAEDGRYPSVSTILGCTTSQHLLYRWQLKMIKQLGGLGAFRKYMRVRMQSGTQYHSCLQRILEELRMRGSFPDDVAEQITSEVDVSVANYLSSVLPILRTLGDKNMELERPTSHHGLCYSGRFDAAVTYKFDVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I789</accession>
    <name>A0A183I789_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid-sensing ion channel 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15601</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042437">
        <property type="protein sequence ID" value="VDP22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I789"/>
    <dbReference type="STRING" id="387005.A0A183I789"/>
    <dbReference type="WBParaSite" id="OFLC_0001561401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001561401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001561401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001561401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9084" checksum="2568AFD62B43DE22" modified="2016-09-07" version="1">MSQKKVMDFDSLLAEVGDFGPFQIALFFIICLPATIPSAFSAFNQPFVVGQPDHRCRLPEGREYLSPIKEFATAVFNRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7B6</accession>
    <name>A0A183I7B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15628</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042495">
        <property type="protein sequence ID" value="VDP22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7B6"/>
    <dbReference type="WBParaSite" id="OFLC_0001564101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001564101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001564101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001564101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3514" checksum="8932431868028846" modified="2016-09-07" version="1">MVGNDPLVQSFPVYIPGTTGVVCPVYKNFHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7Y2</accession>
    <name>A0A183I7Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF2040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15843</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043032">
        <property type="protein sequence ID" value="VDP24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7Y2"/>
    <dbReference type="STRING" id="387005.A0A183I7Y2"/>
    <dbReference type="WBParaSite" id="OFLC_0001585701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001585701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001585701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042816">
        <property type="entry name" value="Nsrp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938:SF4">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001585701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13936" checksum="011222CC773A43EB" modified="2016-09-07" version="1">MSTTALKKYGLILKKPSELSKPIVKPIAAAFASDDDDGIETASSSEVTSSTVRARMQAKREHEKALAEDPTVFDYDNVYEELQAKKNQNIAEIKAADKERKVCLVFFYSSEETILNRKMECKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8G6</accession>
    <name>A0A183I8G6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS16028</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043651">
        <property type="protein sequence ID" value="VDP26164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8G6"/>
    <dbReference type="STRING" id="387005.A0A183I8G6"/>
    <dbReference type="WBParaSite" id="OFLC_0001604101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001604101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001604101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP26164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001604101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7839" checksum="F1478B39B3DA71E6" modified="2016-09-07" version="1">MAARSGKVQKVMVQPINLIFRYLQNRSRIQIWLYEDITHRIEGYIIGIMKKSRDFFVVVTVWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U061</accession>
    <name>A0A3P7U061_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000395">
        <property type="protein sequence ID" value="VDO27706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7U061"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017931386" evidence="2">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="121" mass="13933" checksum="F77951E5C465A784" modified="2019-02-13" version="1">MNNFLSNCFNHRIVWFLALSFTFLFPSNNVCSHIEQILYKKAIVRAYARKSALLEPTAVQPPNSVLDDDTLKEEPETKEGELTENVCFLVLLNADKFSKKFNISKTIKTTKSELISYQRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V7I1</accession>
    <name>A0A3P7V7I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003212">
        <property type="protein sequence ID" value="VDO39579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="84" mass="9643" checksum="B980D8BBD617D721" modified="2026-01-28" version="1">MVPKDVRDEIMVPKNGENMMEKDEVMVSINCEMTQVDKSYGINEEDMEPNGEVMELEDHVMILKRKQGCSVIKRFCGVNGRNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VCJ1</accession>
    <name>A0A3P7VCJ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter, ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS2355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001337">
        <property type="protein sequence ID" value="VDO32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VCJ1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="52"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="367"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="70839" checksum="358E45D29DA0593F" modified="2019-02-13" version="1">MKSKKKKFSNILTSNQIIFRGDFAKQKLDAKPVSFFQLFRFATTCDCFMLSVSALLAIFTGIGQPLICLIGGKLTNVFLLTKTFERNDAFWYQAYIYVYLYASVGITMVITTTIQYICAKNASLNITCTMRREYMKSLLRQEAAWFDQQKTGTLTAQLNANIEKIKDGIGDKVGMILRGVTMFLTCVIIGFIYDWRLTLVMFGTGPISAALLSTMARQTEHSSSMQSSIDGRAAAVLEESIMNVKTVAACNAQETMIRRYAATLKACRKFALHAYAFAGFFDGLFFLVFYGAYLYQIRTITNPGFIFAVANLIMFGSYNLGVLSPHLMAVLNARVAAAVIYKIIDRKPSIDSSSTDGMKVNEVTGRIEFQNVKFSYPTSKEHLVLNGLSWTAKPGDIVALVGHSGCGKSTSVSRKEPLLFSGTIKENIRFGKLDLTDQEIIDACKIANAHDFIDKLCEGYDTMIGAGGIQLSGGQKQRIAIARTIVRNPRILLLDEATSALDAESEVIVQNALKKASVGRTTIIIAHRLSTLRDSNQIIVLDKGQVAEIGTHKELCNKKDGIYASLVKSQQFEEQQKPKSPPVEELPSETFHRSSVRDSHNSSGYGIMSSFTRGSIMSGNVTCVSIPEESTEKSVELNGKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VFR9</accession>
    <name>A0A3P7VFR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000888">
        <property type="protein sequence ID" value="VDO30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858966at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="169" mass="19467" checksum="D68AD77C0B76BB9C" modified="2026-01-28" version="1">MHAGDKKNHHQMDHTYPDMNNIFFKSVPKMIQIADDMHRMTDYIMDLRNMTIGLVCFSFIGAMIFLFLRHIKKRNGADMCERMIMADHPEDLGKFIQSSSDTYRSYSDPSSTIILAKEFSGKTKSTALMMKADGCAKNTRFANNRNHNNKSPLKGTQTRTNKYQCKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WFF5</accession>
    <name>A0A3P7WFF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011336">
        <property type="protein sequence ID" value="VDO59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WFF5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="210" mass="24621" checksum="4EBF89FAE520A116" modified="2019-02-13" version="1">MNTSTKVQPTLRTEKLQFSPSSSSSRITTRPRFKVLHITPKLYQKEIRRNEASDLKPVEIFQQTTKAAPKVTISGFTLVTALLDIGRGDWWEYRRPLESYYGYLENVLQLKVNLVIFVDQKSVRHVYNRRKFYQLEHITKVIPITLAELPLHRYMNLAMRIIADEQSGKSWDQQWDQSMKTHPEAKSAKYDILVNSKSYFLYNASVNHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X6X1</accession>
    <name>A0A3P7X6X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014265">
        <property type="protein sequence ID" value="VDO69731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817605at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="91" mass="10145" checksum="5D566D6450BF5124" modified="2026-01-28" version="1">MGGSQSQSYDLSHESMKSLQEKQDIVPSNNIVDGKLIHVISSENSSKNSNILPNTQELQRIHPPEEIPLTLEEMPSETKTTVPKMIETTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZPV2</accession>
    <name>A0A3P7ZPV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009175">
        <property type="protein sequence ID" value="VDO54778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZPV2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="347" mass="39982" checksum="BBDE4AAAF8949B4D" modified="2019-02-13" version="1">MACCRIQIRQAKLFFCVNVFSVIGVFRNEGVRRRSGDRLRESGDGRRESIYHSDRTRNRANDVAKQEKTIECAKAIGLDSDYLTKLEEQKKMREVILRKKEERRIQTVQRLGGPISVSDQKSVRQLNRTSNFDERRIERSRRMDEEHSNRRKYDSRTRRTSGIRNGKRETVSGTSSDVSREIANSGRLETPICAEKGLVTNSSITQKIESTATANDSSVEQSTAGNTAAVTTTVTSIRRAKRENEQNPERARKKKAYLAVVVNSLNQVPINVDKIRIIAETVGPTKKVWRSSENTVSLIFEEHESAKKFMFHYHRFVHILLLELIIFAFIRCVTRCYLDLFLPDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B315</accession>
    <name>A0A3P8B315_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039858">
        <property type="protein sequence ID" value="VDP11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="134" mass="15398" checksum="6F11E51BC40B3229" modified="2026-01-28" version="1">MNEKICLKIIQIPLLLIYTTLPILSTVFRLSFEGKAICIIILEQKWNEHSFDELVDKRRIENGAVHFKIHILILKLKLVGGPLDLGYFRDFREEKRKEKNDKRASTPPHFTGKIDWAGKGERGLTLLLLAGSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F9S9</accession>
    <name>A0A3P8F9S9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS15174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01041718">
        <property type="protein sequence ID" value="VDP20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8F9S9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="395" mass="45702" checksum="6756E6C85DA24A62" modified="2019-02-13" version="1">MQIFFNDPVFRKCIYDWRPVANFVKPEGEKINIEELMHCIQKLFITLQITPYEDTSAEGLVRLLQLDGNQHDALEFQILFFGKLEKLLSYHVEWHEVRETILKRFQGVITQTISCKCGRRSVTELPFNPFYLSIEKARSLSKALEYYFLPEELPDYKCSECGQTGSAQNCLAIKEPPPVLTIQLNRFTYDGVGHKKKIHSPLQYPRVLQLGDVRYDICAVMIHEGPNADCGHYYDLIKHPGTKQWFTYNDEVVKPSATPGVCVEKERTSKVTADMKGCYALVYRRENEENSTIPVVPEDLLGDIASKLEEEFIAQTSATTEMTLRLKNTVEDYYKSLTKTFDKLQNLDFQELNTVLDSFYKVREMKRGWEGDRYRGNKKKRIVEKSRGGQKLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXW8</accession>
    <name>A0A183GXW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS78</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000018">
        <property type="protein sequence ID" value="VDO24431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXW8"/>
    <dbReference type="STRING" id="387005.A0A183GXW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000007701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000007701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000007701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000016">
        <property type="entry name" value="NIPA1 (NonImprinted gene in Prader-Willi/Angelman syndrome region 1) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO24431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000007701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21575" checksum="CF17C995CBA7DE0D" modified="2016-09-07" version="1">MDPHIFHQSIPIKKFKNSTQEAISENTSYFTMKIDDNATASADDPYSLKSSYSLLDFYIGLGLAISSSLFIGSSFIIKKKALIKLAQVDCTQRASEGGFSYLREWLWWFGVLTMGTGEAFNFAAYTFAPASLVTPLGVLSVIVTAILSSKLLKERLNLLGKIGCAVCLLGSTVIVLHSPKEEEVSNMADLALKMRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY47</accession>
    <name>A0A183GY47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport protein Sec24C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS157</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000039">
        <property type="protein sequence ID" value="VDO24762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY47"/>
    <dbReference type="STRING" id="387005.A0A183GY47"/>
    <dbReference type="WBParaSite" id="OFLC_0000015601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000015601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000015601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000020">
        <property type="entry name" value="protein transport protein Sec24D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="9">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="10">
        <location>
            <begin position="499"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="12">
        <location>
            <begin position="749"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="11">
        <location>
            <begin position="842"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO24762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000015601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120903" checksum="ADDEAA677AD66610" modified="2016-09-07" version="1">MPLRSAHKSAWTDLYHSEEAMYHTAAPPSFIPAGQLVGDHNVKGAQIPYPGSVSAEQNRMMAGSAVSQNGQIPQNMTMQSGTVYGQFAGQQGFPSQFTASLEMNNGKTVNGGAHLFSNPPSNFPNDVRLNSGTISNSPPTNSQLISPKISVPSTMTASSTATFTGNISAMPGVDTFPHILPPSQPLPQMAPNTEIVPPRSSMGVIPPSDPSMTQRYFGTSTQNATSETGGEAAPKHPRFGGLTGPNSFPKPTGSSGSQMSVPPQMPGVYSSPSSGSLGLSSVPGAPSVNYGTGGAGIAGPSMHGEIIGPPAPGLYQQKPRLDPNLMPSVVQVIEEDRSTRSGTFPTGYPTAEHPPLTSTEFVAQDQGICSPKFMRSTLYVAPASSDMLKNSQIPFAVAVIPFARLHSNEMQPPIVDLGELGPVRCHRCKAYMCPFMEFQDGGRRFKCPFCSASTTVDDSYFAHLDHTGRRTDIQHRPEQFLGSYEFVATKPYCKNGMKPKEPAFIFMLDVSYSAVHCGLVSIFCRNIRNLLNNLPKEMSQVKSSLRIGFATYDQTIHFYNLKSHMGQPEMLVVGDVNDIFVPLVDGFLVTLEEADVVLNSLLHEIEKIFGDTRITETMLGPVIQAGLDALKCADRAGKLFIFHTNLPLLDAPGKLKNRDDRKLLGTDKEKAVLQPHTDFYSKLGEECVKAGCAVDLFLFPNSFVDVASLSPVCSLTGGSIYKYQYFETQKDSERFLADLSHDISREIVFDVMIRVRTSTGLRPTGFFGSFFMDNSTDLEMGAIDCDKAIHVEIRHDDKLPEGNAHLQTAVLFTSCSGERRLRIHNLALSVSSDYNQLYRVADLDCLTSFLFKYAEYFLRDKSPKEMREAVNARCAQMLATYREKCSEQAPLGQLILPECLKLLPLFANCIIKNDALSGGNDMTVDDRAYLMHLIPSLKPEDALTLLYPTVFPISDLILEQHSSEITVPICIRASYDNLSPEKAYMIYNGIMMFLWIGLKVPQDWIQDVFNSNSVAHLNVENHIVPERDNARSRAVRYIIDRMNMNRLRHMKLFIIRQQDALEAWMKKFLVEDRTSSTPSYVDYLCNIHREIRSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY51</accession>
    <name>A0A183GY51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS161</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000040">
        <property type="protein sequence ID" value="VDO24777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY51"/>
    <dbReference type="STRING" id="387005.A0A183GY51"/>
    <dbReference type="WBParaSite" id="OFLC_0000016001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000016001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000016001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000016001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39595" checksum="87F2C5C829FED4B9" modified="2016-09-07" version="1">MVEVNPEEDVTKTTYLHPGDVLGEWTVLDKIGEGGFGAVYLVKDKKGNEYAMKTESVNAIVKVLKAEYYVLTELKKAKAKHFCDILDSGLIGENKYVVMTLVGQSLTVDITVLSFDPIHFDLRKHDPTQKIQKFTMGCAISVGIKCLEAIEELHNIGYLHRDIKPGNFAIGRKNLRQIYLLDFGMCRKYINNHSTIRNPRRSAGFRGTIRYASISSHISREQCRKDDLESWMYQQVCNFYFFLPPKITKLKMITIDKDEVGRCKQLCRKDECIKELFGGCPREYITILRLIDSIRYYSKPEYKKITDLMYDALRNNNVSEYPYDWEKYLESPRNTGGTEVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY54</accession>
    <name>A0A183GY54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTR5A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS164</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000041">
        <property type="protein sequence ID" value="VDO24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY54"/>
    <dbReference type="STRING" id="387005.A0A183GY54"/>
    <dbReference type="WBParaSite" id="OFLC_0000016301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000016301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000016301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000016301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="971" mass="107631" checksum="B58C32A0631626FC" modified="2016-09-07" version="1">ILRKVSVCCLRQLVQREAKEVREHAQTLVPQGIMNNMGRNNLESGLPETGLEGALLAMLDVETDVKLKQDIKETLISLVQAASGDFLSYWLSLCKDILASSVSTDVRSAVQLEERGPNGTKDEEDEHETMDDDVTLQSATVMSREEKMKVIPRWPSRVFATELVQRVMSVCETERAHFDLALAKELQISSNGRADYLVLHLSDLVRMSFMGATSDNTSLRLAGLACLQDVITRFSSIPEPEFPGHVILEQFQAQVGAALRPAFTADTPSDVTAAACQVCSTWIGSGVAQDLNDLRRVHQLLVSSLGKLTHGSINTQLYSESTATLEKLAILKAWAEVYIVAVEQKKQKKVVDAAALKNEEKSNCLQESLLSLVSPELNSLINCWLAALRDSALLSLPPEFKSQLPTKGGTYYTAECADFCKEHYRVSWPPILLAACTWLKQNDFELQQSSGDLENMTINKAKETHFHIMLGICIETLCSNRMYSVGDLTIQLCLRSLRNLLACNWSRRVLMKNVQLPIEVINVLYRLILTRENLRTQQLCADVIMTVLDAAQYSITLYDIKNDISGQQNNANKEGYKGEEGTADGLQPANSLVFAVLEIALCLLIPQINSALMKSKSTTPLHYRRYSRLPIESNNLIKMGLNILIRIPMLCSPDGTIVILPSILYLILGVLHESSLIDKEQLVPDLPFGHVSIAAAAAMQALKTLLTTAPSDFTFSKWTSIMRSTLISLLNMAEDSKIDGAVIMLAVAVFVTSSPPQLVTDNINLLARICKLFQTYLESEHKQVVVKCMQSLASIFGRREICYPFIAELVPKVLNRIRPFITSVSEGIAEIPESDDVLIVQEAVHILEVALSVADQKKQLAIVNLIVQLLGTFLCEDPATYYRQLPVSARKLHDYALNRLNVIGPSHLEEFKKVLLSFPALKSKIEGSIRHAAQQTQRTTGLGKCEQMLLPVPKSAAIKLKVDFRAFSPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYQ3</accession>
    <name>A0A183GYQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS363</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000113">
        <property type="protein sequence ID" value="VDO25533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYQ3"/>
    <dbReference type="STRING" id="387005.A0A183GYQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000036201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000036201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000036201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO25533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000036201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43066" checksum="25AC456AE227852A" modified="2016-09-07" version="1">MRSFSKLLENKIIACYNSCLQTLWVAWRAIVFGLFIIAFGILMTVLGYFDVYLSQGTLRSGIGSIDKVILHSWNTSTNRITLRNRNNKIDKIFTTWAMRYFFKSLQYIGPIAMGIGTFILIIACMFNNVGEVGPRKKKSLLQRIIVQKPMINKKCLPMTNKEICEWTPRYKAVPLSTHNSSPIMDKWRKYRSTPCIPQMLLDTIENRKLCWRYLDNYYCGIFDTENDLEFDARDHRACTFTSAKCSYICPRQNVTVELHNPPPLLLSSANRSSPLQISPVASSQQNQSSLHSFSNFKRTDDLACNEHNSSNIFVSIDPTVTAPVTDTVDSAVDVTRDNHTVPEESQRHAPLASLDIEFGTSSSSSSSNLKVPNIDSFLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZB2</accession>
    <name>A0A183GZB2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS572</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000199">
        <property type="protein sequence ID" value="VDO26262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZB2"/>
    <dbReference type="STRING" id="387005.A0A183GZB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000057101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000057101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000057101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552312" description="Cytochrome c oxidase subunit 1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO26262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000057101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16878" checksum="1F83CEA15136FF8F" modified="2016-09-07" version="1">MSFIFIVALPVLAGAITMLLADRNIGTSFFDPAGDGDPILSQHLFWYFENKRNILCLTLTNAAANKMELLYQTHNNNHNLNSCFHENCCLLDKNIEDDIKSRNLTPKYLDLAKLHIKRDGLLVIDWLIIEPFEEPSSNTIILKFAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H086</accession>
    <name>A0A183H086_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS896</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000364">
        <property type="protein sequence ID" value="VDO27487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H086"/>
    <dbReference type="STRING" id="387005.A0A183H086"/>
    <dbReference type="WBParaSite" id="OFLC_0000089501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000089501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000089501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO27487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000089501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="35489" checksum="FE7A4C19DE3478A7" modified="2016-09-07" version="1">MHEVPVYWKDSEMTAMIFRHEKVHNDLFQCLWIPLSITRLYSTTPNQSRNEQRDLYQTLGVDSSATAKEIKAAYYQLSKIYHPDRHDGEEQKILAAEKFLQVAEAYEVLSSDEKRKAYDNKCQENWIQTPTGSWPTQMRVKKNFEDLGLDYKTFEDFQRSVNTRKHWTKHDHWQMPDEFFAHFGSPRKFTSTFRPRTATYFTYSYKDPMQRQREMREWQILKEIEEEKRNSKYKTPTFVVMERERKRRELSEKRTLNVLLLFFGCITILIYIQRLKAAPTDTVSNRMVVQLIHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0N2</accession>
    <name>A0A183H0N2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 8">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1042</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 8"/>
    <dbReference type="EMBL" id="UZAJ01000444">
        <property type="protein sequence ID" value="VDO28010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0N2"/>
    <dbReference type="STRING" id="387005.A0A183H0N2"/>
    <dbReference type="WBParaSite" id="OFLC_0000104101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000104101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000104101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="487"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO28010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000104101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1014" mass="116726" checksum="33F147240082610D" modified="2016-09-07" version="1">GDEVVASESCYIDDIIDVFSDCCAESSRRQGIHQKLDGYIKKTLAGTFFAEKCTLSTQFLTVMYGTDAVSPNALIFLIDSEYNVLRWLNELRRLSVKALKELSFQGCFYYWQRLFTKIKHSTDTDQVSINDILDAVLFIKNKEDRKDIEKSLKALPAFHSKVVFSFVLVELLGQLVERFVLVELSETISTDEITNDFVFSCYCCICERTDVDYIFRKKFGGKKTVDAEHFAKYLKEEHYDPRLNELLYPSPTPEIAQFLISEMSRNKEHLTKESFLRFLLSAYNIGMHRHHLMLKEENMHKPISHYFINSSHNTYLKGYQVNSKSSVEMYRYVLLSGCRSIELDCWDGSGGEPIITHGPSQLTRVTPVLFKDVIIAIAETAFLISEFPVILSLENHCSVKQQKKIALYCREIFGNLLLTEPLSNYPIKQGANLPSPNALRKRILIKNKKINDAGTEDFFNRSTNDIIHQNEANIEEQLQSSLVARELSDLVNYMRAMGKFTSFADCESRQMSSELFSMNESRAYELVKQNPIEFVNHNKRQITRVYPKGKRVDSSNFWPIKFWNCGCQMTAINMQTPDIPFQMNAAFFEQNGRSGYVPKPSLMRKADAKFNPFETHTMDLVVPAYLSVTIISAQMLSFACEKRPSTYAEVNFYGHFNDLSRFSKRKYRTRIVMDNGINPIYMNFCEESFKFEKRAISSLKVYKFTEGRGSLSSILQIIFPAMASIRLAVYEDNGRLIGHCFLHVRSIQPGFRHIPLRNAHSRPLGPVSLFVLFLVHDYIDDGSVNLVNALQNPIEAMKKIMESEEAASAALINPIDTMKQREKMLLALEESEPQSLSAESALWDIQRSEEGKEFSRMTQVRSFENNAGLLSKMKFSSVESELGKEGGICEDGMKSLSFDKRNLSEKLKERFYLDDMEIRFLSEDELASSQKVVKLEKIFKKKHQSILDLLDVSSKQKYWVPSAMNSVPEDAFAIYAKYEKERTELIILLVEQNRKKLIKRLDMAYKCVWDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H131</accession>
    <name>A0A183H131_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein detached</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS1191</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the dystrophin associated protein complex (DAPC). Interacts with Dg, via the Dg WW domain binding sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000525">
        <property type="protein sequence ID" value="VDO28592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H131"/>
    <dbReference type="STRING" id="387005.A0A183H131"/>
    <dbReference type="WBParaSite" id="OFLC_0000119001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000001">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="15">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO28592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47543" checksum="EC7DD74A4F3D101D" modified="2016-09-07" version="1">IPRLFGEAAAFGGSNVEPSVRSCFETANYPRTISVDEFLNWLKKEPQSIVWLPVMHRLASAEFAKHQAKCNVCKMFPIIGLRYRCLRCFNVDICQNCFFSQRLAKNHKLSHPIQEYCLPTTSGEDVRDFGLIVRNKLRSKSKTRIGYLPVQTVDEGPPLESSNTSPFNPFTEPIHNRIQLCARRLWRARGENDSPVPLSIEPGEEMLMNMTELKSPLQLLSQVEQMHKEELDQVLHKLQHENRELKKEIEKRRKFGNAVGSTPNLTRGSSAAMSRSVTDNMGTGRSVPSLSNSGDDQLLREAYLLRQHKERLEQRSRILEEQNRQLETQLARLRTVIAQQQNIGSESKESGSEEHESSVASVEEDEGIEYDTRPNRMNSLIASVDQLGRAMQSFVVSMVNDEDETVEDEDELTITGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H186</accession>
    <name>A0A183H186_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1246</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000557">
        <property type="protein sequence ID" value="VDO28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H186"/>
    <dbReference type="WBParaSite" id="OFLC_0000124501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000124501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000124501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000124501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18764" checksum="77E9044149F8C681" modified="2016-09-07" version="1">MKINSCQRCKTKKKGKLKLEASAWASSTIICFQTSREIEINERLVADRRIEIEQNFHDNANDNDDDDDEDTVAENYSHTQRRSLPKPTSSSISPPPSPSSSLSSSSSSISSSSSSPPSSLLLSSTTKTAEIVIAQPAITTTSNSSSTDDIAVNSIAPQQLRQQQQYPESHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Z4</accession>
    <name>A0A183H1Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1504</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000720">
        <property type="protein sequence ID" value="VDO29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Z4"/>
    <dbReference type="STRING" id="387005.A0A183H1Z4"/>
    <dbReference type="WBParaSite" id="OFLC_0000150301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000150301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000150301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="279"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000150301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51406" checksum="259B8B95FB93E1D6" modified="2016-09-07" version="1">MMIPSNRGILPPQSKCYSTTSDFCPQQSYWPSVSPVMSSNRSPVNTAILSPICSATSTATDLLNLLHAVFLNNPITNNEPRSLNSEQHYWSTLPAVYSGDTVFTTSIASCSSAVISNKYQCNINLEGNSVSVTNYNGNFSTLNPDHEISADVDQTGGFFDSSGGTLSSSVQRMPFYIERQHSSFTSESDTSASLASLTSDLMDFAYQYHWSTAAQQHKYALNLCCYSSKQSYHYADNSNSSLRNMEQKTEFSNTRPRMPLVAPVRLSPRNEPLTLFFTDKYVFSNHYLCQQLCIDGMNFICTEQYYMYWKARLFNDEDTAMAIMASRDPKQMKMLGTKVKNFSQPIWDKFSTQVMAIANQRKYEQNKDLRQALFRTMYTILVECNPRDQRWGIGLGMNEPDACDPQRWRGLNLLGRLLTRIRDRMAENAIYRNEVVEARSIIHFKSVLSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H279</accession>
    <name>A0A183H279_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1589</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000779">
        <property type="protein sequence ID" value="VDO30081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H279"/>
    <dbReference type="WBParaSite" id="OFLC_0000158801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000158801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000158801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000158801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7640" checksum="4B31B7714914BE62" modified="2016-09-07" version="1">MGKHDKGLSKKPRRSKEFLQPDGEMAQSAEKDKEDKQTDGWMDCLIADSLINEYYRVIGPFAYWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2A3</accession>
    <name>A0A183H2A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma-secretase subunit aph-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1612</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000795">
        <property type="protein sequence ID" value="VDO30155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2A3"/>
    <dbReference type="STRING" id="387005.A0A183H2A3"/>
    <dbReference type="WBParaSite" id="OFLC_0000161201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000161201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000161201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO30155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000161201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35928" checksum="833833FFB6747571" modified="2016-09-07" version="1">MGVLAGIGYLFIAFSPSVVIFRRVIASDPLRIILFVLGAFFWLLSLLLSACVWFAMVPLREHLVFAIAVSVALQEGARFLHFILLKKAQNRISLKYLLEITPEIIQFFRGLVHMSVAGQRIAGVHTLQHARHILATVCGLGMGVMAALFLIINVIADFWGHGTVGLPATVPYVSNRFTVKLLPNDQYFPITYSISACMVTLCHVFWTVLFWDGCHKKDATSTWWMGICFAIISHYAMSALSFGNRTKYQMVVMCVQGAIVVINAVISFLVMGITWPMLKSKTKLAFYRLLCIRNCNSETTDASISRPENFTNRSDSPNIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H306</accession>
    <name>A0A183H306_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1867</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000973">
        <property type="protein sequence ID" value="VDO31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H306"/>
    <dbReference type="STRING" id="387005.A0A183H306"/>
    <dbReference type="WBParaSite" id="OFLC_0000186501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000186501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000186501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000186501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17274" checksum="BD7F39F1E923412E" modified="2016-09-07" version="1">MLSASGRIISGNARFVRPCFVYPTLQRYVAGGVSDRPQFDPINARKTFKETHNHSTMFKIEKYFSAAMVPLLPAAYFIHGPAMDTALAIAITLHVHWGLHGVLSDYGRPYVIGPTMAKIVQGPLSYILSICLLAGLLHFNSYDVGITKAFEMVWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H321</accession>
    <name>A0A183H321_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1881</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000981">
        <property type="protein sequence ID" value="VDO31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H321"/>
    <dbReference type="STRING" id="387005.A0A183H321"/>
    <dbReference type="WBParaSite" id="OFLC_0000188001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000188001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000188001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000918">
        <property type="entry name" value="Myosin Light Chain Kinase related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000188001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40364" checksum="7F5012660071B1D2" modified="2016-09-07" version="1">MVIFTALPPGTSNDEGRILVDESDYRGVDDEQLPFEIKDVVRIRADAKFSKYYDCMDELGEGKFGKVYRCREKATGLELAAKRIKIKRDADRDKVEREVAIMTQLRHPRIAQIYDAFATPDNDVVLIMEIVSGGELFDRVVDENYILTELAVVMIVCQICEAISYIHSKNIVHLDIKPENIMCVSQTGNRIKLIDFGLAQFYDGSSNLLFMAGTPEFVAPEVIKFEPIDFYTDMWSIGVITYILLSGISPFLGETLGDTYVAVEKGEWEFDDEAFESISDAAKDFISKLLIMDQKQRMLPEDCLNHPWVVDSRAKAANDLILNQPNSGTPLSKEGLKSYLRNKRFRIFYQAFAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3U4</accession>
    <name>A0A183H3U4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2154</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001180">
        <property type="protein sequence ID" value="VDO32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3U4"/>
    <dbReference type="WBParaSite" id="OFLC_0000215301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000215301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000215301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="3">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000215301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18945" checksum="9E5F9795F0F2D821" modified="2016-09-07" version="1">MGDAGRGSSHGSGSNYCDLKDDGVENVIKFTCFLCGLTENCRYGLVETSGRTHTYRYKDEMYYMMDPFRNRSAVNERRLTQTRANTGSKTSEESKATSIFDILVLGAICSKCGQPVCIDENCSVFYTKTFCIICVIREKIHFPRKFIEVLFFFFAKKSNEAAHNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4F4</accession>
    <name>A0A183H4F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2364</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001346">
        <property type="protein sequence ID" value="VDO32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4F4"/>
    <dbReference type="STRING" id="387005.A0A183H4F4"/>
    <dbReference type="WBParaSite" id="OFLC_0000236301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000236301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000236301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000236301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18990" checksum="E6460E6F738F0D9C" modified="2016-09-07" version="1">MRRYRTAFSREQITRLEKEFARENYVSRPKRCELATQLNLPEGTIKVWFQNRRMKDKRQKMASLHWPFFDHHVTAYFLNPFCYEAWRSSLIPKLCDSSITRPFLTTGGSMLGSVAVGTGTNVGIIPRPTICANPVVTSIEPTRDRIQEPLESTSLQSSSETKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H753</accession>
    <name>A0A183H753_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3315</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002181">
        <property type="protein sequence ID" value="VDO36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H753"/>
    <dbReference type="STRING" id="387005.A0A183H753"/>
    <dbReference type="WBParaSite" id="OFLC_0000331401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000331401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000331401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="401"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000331401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="70057" checksum="66282288522DFA5C" modified="2016-09-07" version="1">MFFPRGRFVSFGSGETYLMDPSQFGFSERDMPELEGGKYIAIGASKGVRIIEGPQEGGINAAMVIDVKKAAFHADNQDLLEKVECLLRKDRSDLKRGVDQQSIAILNKALKGLYVLCNYGKKRAFTVTGVSKENARTSKLVTKSGEMSVEKYFEMKYSMKLKYPTLPLIMERSQPKNNFYPIEVLSVCENQRVSKGQQTSSQVQTMIRACATVPSLRLQQTNALSKAMKLDATGENKWMKNCSVVVTNNLMFPARVLPSPDIEYRINGWVKPSEKTSWLTGKNQYLIPAVCNKWYAVALIGPREGRMNENLFRNYIRIFLQHCRQHGMEMSEPLGCEYIRRANQQDIEPLIIKAKNLGATFIHFVTADELNYHGHMKYIESKEQVVTQDLKATTAVAVAVQNKRQTLENIVNKTNIKLGGLNYSVHLETNCDKWLTKAGFLVVGLDIAHPAVSMVSRKDRNFVPSVIGYSANIKKHPLDFIGGYRYCKAEMEELVDDTMQEVFSYILRYYKASRGEPPNHLFVIRDGVSAGQYKYVMNTEVQQIKKACQMVGGPNFCPHITFIVLTKMHNVRLYKKNIHKQERPAEQNIKPGTIIDKHVVNPVLNEFYLNSHLAFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H765</accession>
    <name>A0A183H765_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3327</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002193">
        <property type="protein sequence ID" value="VDO36117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H765"/>
    <dbReference type="STRING" id="387005.A0A183H765"/>
    <dbReference type="WBParaSite" id="OFLC_0000332601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000332601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000332601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="4">
        <location>
            <begin position="193"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000332601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41127" checksum="F991860E2830899D" modified="2016-09-07" version="1">MSWNEVFAGPIAQFPRTPLMHRGPSKAISRPPRNHLNGHPADDLDAQSTSDADFVDITEKDKLRKRSKKASLEKDKKENGKKGGDGKKTKKKKAIAEQQEELESLFEQARKVNIENLSRWEQDERLLSEAEVVELKQLIRQTKEKEREEKRLNKQRTKEMLLEWKKPRDDILCDDLQPLPELAPLLLPLWMSDDDFGDYLFIFEFFQSFAELLPIREIRGTSQVKFSEIISAVRSRTPEQDSLFVQLMHILLKAKSERADEEDGDEADLSNKEEIPLDANDIDHKIYGLSARHLPIDWMTLTEVLRLSLLTSGYYTGTPTHRFRLFSRGAIRCYEDEGFLFAKDNPHTMSILEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7X9</accession>
    <name>A0A183H7X9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3591</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01002455">
        <property type="protein sequence ID" value="VDO37061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7X9"/>
    <dbReference type="STRING" id="387005.A0A183H7X9"/>
    <dbReference type="WBParaSite" id="OFLC_0000359001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000359001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000359001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO37061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000359001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33921" checksum="EB3D31BDA9323EAC" modified="2016-09-07" version="1">MRVNEKRQSCVLGCKNETSCGEVIIPDEHLYQCRYCTSPYSQNCAVTGPPDGIGVPNTDFLLYVSAVLSERCKNVDTVAYAAHCQQEADLDRPIAGHVNLCPNALSTALHDREVLISTVKHEILHALGFSAGLYAFFRDDNGNPRTRRNRYNKPVSLNKRHGYYNWDQNTIQTIIRDDWWTAEGMISHPVHIMVTPRVQQEAQRHFNCSDLEGAELENQGGDGTAFTHWEKRLFENEAMTGTHTQNPVYSRLTLALLEDSGWYKANYSAAEELLWGRHLGCEFAKKSCGEWIRNRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8N1</accession>
    <name>A0A183H8N1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3841</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 6"/>
    <dbReference type="EMBL" id="UZAJ01002706">
        <property type="protein sequence ID" value="VDO37932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8N1"/>
    <dbReference type="STRING" id="387005.A0A183H8N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000384201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000384201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000384201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000094">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="7">
        <location>
            <begin position="119"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000384201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46946" checksum="62D76D3ADD8F4230" modified="2016-09-07" version="1">MDVNKVCTDLLNDVSGENIPVEVDIIARKEQCKMYYVHYDGMDRRLDEWVGRNRIVARANPNAFTSVLSVPSSLSGTLESGTLTRSQRRIHEEFNHVQKSYEDMDATTAKLEKEHAEMTKVKNIDKIRYGDYEIDAWYVSPYPDEYSKAAILYICEYCLAYMRTEAEYCCHMLHYCDRRQPPGDEIYRDGNLSVYEVDGKVNKAYCQCLCLLSKLFLDHKTLFFDVETFLFYVLCEVDEVGAHVVGHFSKERLSANNLACIMVLPPFQRKGYGKLLIQLSYELSNREGVIGTPEKPLSDLGKVSYRSYWWWILLEALDRLNIDDVTVSDLSSASGVAEDDIISTLQTMQLIKYWKGDHVVRMTRRLVEHCKSINMGRPPKLLLDPDLLRWWPKKRRQISHRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H916</accession>
    <name>A0A183H916_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3980</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002852">
        <property type="protein sequence ID" value="VDO38463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H916"/>
    <dbReference type="STRING" id="387005.A0A183H916"/>
    <dbReference type="WBParaSite" id="OFLC_0000397701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000397701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000397701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO38463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000397701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37850" checksum="50A02CABA94F1DEA" modified="2016-09-07" version="1">MQIGIIVFLAHIGSFVPAKSAIIGSVDRIITRMHTLDCVLDGMSTFATDLSQIAFALRRGTGNSLILIDEFGKGTVMEAGFSLLTSSLNYWIRKGKTDCPHIFAVSHFHSLIDYVVKDVNLLSFLTMDIMLNDGNFDFQYKLVDGFIDCSHASYIASKVGIDNKIIKRANQIHKCLKCKTPIDPLDYDGELLFKIVPLLENLKNINFTSDLKNFLQVMTDLLLPGKERDVTVIEDNNKSDDIKIKIEDGVNIGEEETDLTRSDNVTRKLGESYGSTSETLQKLENSAVNFTNLQVESGGNDSMLNVLESFLNVTERSSIMKKTQFEYASLNFLSKFKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H936</accession>
    <name>A0A183H936_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neutral alpha-glucosidase AB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3999</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002880">
        <property type="protein sequence ID" value="VDO38547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H936"/>
    <dbReference type="STRING" id="387005.A0A183H936"/>
    <dbReference type="WBParaSite" id="OFLC_0000399701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000399701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000399701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="1">
        <location>
            <begin position="78"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000399701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26436" checksum="63588C1C5459F772" modified="2016-09-07" version="1">MWLLIWGVPMNLPVHLDISSISSVHETKHRIIKRKLAAGWRHRTQTEKANYIVTAGTVTHNSSTLTADLVSRVNKLKLSIVSLNDATIRLLIDEKEGAIRPRFQPLDALKDGSNLKTLDFKSVEINDNSTIIITANNAKVLLNYEPFRIDLFIKDELVISINPNNALKFEQFRKKEDGDEAKGAEGFWEEDFKNHHDSKPFGSSSVGIDLSFIGYKFIYGLPEHADSFALRSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAC1</accession>
    <name>A0A183HAC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF433 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4434</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003369">
        <property type="protein sequence ID" value="VDO39999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000443201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000443201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000443201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000443201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4845" checksum="BD0C1CA270E02214" modified="2016-09-07" version="1">MREHIERHVTIVDPPSDTSIGSISLRNDINDRYYSLFVNNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBB0</accession>
    <name>A0A183HBB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4772</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003797">
        <property type="protein sequence ID" value="VDO40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBB0"/>
    <dbReference type="STRING" id="387005.A0A183HBB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000477101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000477101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000477101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000477101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7717" checksum="03B729C6EDBDDDD4" modified="2016-09-07" version="1">MLTVNPKKRITAEQALKVPWICNRERVASVIHRQDTVDCLKKFNARRKLKFIKSSETELMFRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBR7</accession>
    <name>A0A183HBR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4929</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003993">
        <property type="protein sequence ID" value="VDO41480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBR7"/>
    <dbReference type="STRING" id="387005.A0A183HBR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000492801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000492801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000492801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO41480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000492801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20602" checksum="F6B216F021688DDF" modified="2016-09-07" version="1">NGRHYKVAIVRTKTRGWGVFALEDIPSNVFVVEYVGEVLTIAEGDSRNDSMYQFELNGYNEIKYLIDAKYYGNEAAFINHSCDPNLIAVRIRIERIDQSYYRIGLFSKCRISRGQELTLDYFSGKCKPKTILTSEEGAVKCFCCALNCIRYWPRLDENAVDNASSDEDNKENYFAKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBY6</accession>
    <name>A0A183HBY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4998</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004085">
        <property type="protein sequence ID" value="VDO41723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBY6"/>
    <dbReference type="STRING" id="387005.A0A183HBY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000499701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000499701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000499701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF133">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="209"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000499701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44926" checksum="2186277921321589" modified="2016-09-07" version="1">MIKFGLISTKVIDYDSKMFKSRLLIVPGEGIIWMGSHLNLSVGTFFKFSSPTGDFYGSAILQIDSAKVKSYFVTAINTDGHLRTDLQKCTLSPGNVVMNFSETDPLLLVNYYPHIDRFISERIEMIICSSFNTELVPIVSNLLMNTPMSAALFDHYFLNYGFIEQIKYLPDAIELKHRGNVFSIVRQGQNRLNDFRLPFSSAPITVDTQEKSAMLEFTMSNYTLASLLYWMDQYRNFDYEISKESINNTLLVGYLRTECDAEDVCAGNLFPALSNQYPDGVVQIKSRTTTYPRVRLEENKGVIVIWSQVDAFVQQSDGAHRFLTSGMMAELRIEKGIFQNYSFTSELRIEKFKIFDVISLVDGIDETSLEFLVSALNELLIGDEVARKLSDGEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD06</accession>
    <name>A0A183HD06_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5368</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004575">
        <property type="protein sequence ID" value="VDO42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD06"/>
    <dbReference type="STRING" id="387005.A0A183HD06"/>
    <dbReference type="WBParaSite" id="OFLC_0000536701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000536701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000536701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514014" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="3">
        <location>
            <begin position="110"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00046750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000536701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39770" checksum="A366CB42DA1D12C2" modified="2016-09-07" version="1">MGRGRMWYAILSSLSLFLFVVDCATPFLNTYLDERSQNKEEDFMKSVEQHLVIMPANLFVHHKLSSCLNLLNHKLGRIQRMADIMTLSVMISTGDNLHIDLTVMYPCNNDELSSIHHGAAGLKLEGISIEASKNKALCDMVQKVNSAELVQLYHAVSAAAALKECTFSIPNAKETVEAVLKQDAPTSHNIYLALAVAEKLKLKVNYNGFAEALTTALTKDDGASSLAYGLNAAALLDNINAAKFLVRAEDLVGQADEVDGKYLHLEGGLSITAFGVYGIYSLADKLNKSPSVKSDEAVKLANYLLSRKTVQLDRGAYLLLLTLKKLANNHFQIPVVFSLASSSSLLDTDKVNLFRNEFLLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDA5</accession>
    <name>A0A183HDA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS5468</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004714">
        <property type="protein sequence ID" value="VDO43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDA5"/>
    <dbReference type="STRING" id="387005.A0A183HDA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000546601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000546601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000546601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15285">
        <property type="entry name" value="7tmC_mGluR_group1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000546601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53730" checksum="2CADB602D9609094" modified="2016-09-07" version="1">MICYPLEHEGPDWSSTDIILALLLASLGTIITLFTILVFIRNNNTPVVKSTTRELSYIILSGITICYAVSFAVLATPSFLTCFIARTLPPIAFSMIYSALLTKTNRIARILAGSKKRILTKKPRFLSTSSQVIITWILVCIECIIVGAGVMGEMPQAGFDPYYQPQRMVLVCSTTTFAFLTPFFWNLFLISLCTLYAVKTRNLPENFNEAKFIGFTMYCTLVVWSAFIVLHLGTTNKALTMSFLFSLSASIALVLLFFPKLYIILLHPEKNVRASYTTTKLIRCHFGNSQTTERASKETSNWKSGVSQRSLSRSDTESQVKHGSSRKRRPSLHASQSPSQDASTQTDTVNLASKLARKFSLISNGLGTVGTSSSQHGIRELDDEVQELIDSCRRYQASQNKRLHGSVRNLLLEEKEEEIDNIGCLIADSMQTVLSTVSKQFLPMGSQLLNAHISKENNSKSEDSKFEEVWCNILYDFKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDI9</accession>
    <name>A0A183HDI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004831">
        <property type="protein sequence ID" value="VDO43512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDI9"/>
    <dbReference type="STRING" id="387005.A0A183HDI9"/>
    <dbReference type="WBParaSite" id="OFLC_0000555001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000555001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000555001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000555001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10800" checksum="502EE02B65D2A298" modified="2016-09-07" version="1">MVYDIDYALHIACRLLIYYENFFSIPYPLKKLDIFTVPELRVLAMENWGLITVRQKLMIYNQRLNSLRERRVVTDVIAHEIAHMVNSRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDV7</accession>
    <name>A0A183HDV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5669</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004996">
        <property type="protein sequence ID" value="VDO43909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDV7"/>
    <dbReference type="STRING" id="387005.A0A183HDV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000566801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000566801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000566801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000566801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15856" checksum="0F8AE98D00AD2CD0" modified="2016-09-07" version="1">MCDGNVMEHCRSSCGQACHICALNLILITLISIAVCVPAISSTLSLLLCLFISAFITIRMMHFVMEKPLPIYSEELICNSSEYTLDATAYWLGFRKVPIIGNYVGVSVNFVKFHMIMNCDLSSKSLYAAIQFNLPHHQCLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HED9</accession>
    <name>A0A183HED9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5848</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005257">
        <property type="protein sequence ID" value="VDO44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HED9"/>
    <dbReference type="STRING" id="387005.A0A183HED9"/>
    <dbReference type="WBParaSite" id="OFLC_0000585001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000585001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000585001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000585001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8817" checksum="8A6E30135436C161" modified="2016-09-07" version="1">MQTLPFSNPSDVSFGNTHSQGATVSITCTERGQSAMVEGYDQQRRSITSSPSLMATCTNVGGSQYTWTTLGKILQFVDCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEV8</accession>
    <name>A0A183HEV8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6018</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01005485">
        <property type="protein sequence ID" value="VDO45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEV8"/>
    <dbReference type="STRING" id="387005.A0A183HEV8"/>
    <dbReference type="WBParaSite" id="OFLC_0000601901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000601901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000601901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000601901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14653" checksum="F05C424173B10770" modified="2016-09-07" version="1">MCSSVIEVRVALIGMTGCGKSALAVKYIAGRFIGEYDPNLEETYCRQDVLLSQPLVVWLMDTVDGSGRDAMRYLSWADVYIIVYDITSQLSLQYAESTMQQISAHEHHLCAWQHKCLLVGNKTDLERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF03</accession>
    <name>A0A183HF03_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6065</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01005560">
        <property type="protein sequence ID" value="VDO45281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF03"/>
    <dbReference type="STRING" id="387005.A0A183HF03"/>
    <dbReference type="WBParaSite" id="OFLC_0000606401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000606401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000606401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000606401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17822" checksum="11C2A6C703327F61" modified="2016-09-07" version="1">MWFDLDEKKTWWHSLAKYFLTFGPIPEHIAFIMDGNRRYARRQQYLSLAEGHRKGFDKLTKVMQWCREFGVKELTVYALSLENFKRNATEIDDLLTLFEQKLTLLLDESLVDKLIKNGIRIQFFGNLEHLPLKLRQHIAKIELLTREHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFK6</accession>
    <name>A0A183HFK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IF-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6269</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005860">
        <property type="protein sequence ID" value="VDO45971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFK6"/>
    <dbReference type="STRING" id="387005.A0A183HFK6"/>
    <dbReference type="WBParaSite" id="OFLC_0000626701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000626701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000626701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF- 2" evidence="3">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor Tu-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000626701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35851" checksum="4E6CA2336017186D" modified="2016-09-07" version="1">MPQPLKELRVKNAYEHYQMIKGAQGVKVLAKNLEKALAGLPLFVANREDELLVLKEDCEAQLSKALMAIKKKPEGVYVQASTLGSLEALLEFLRTQKIPYSNVNIGPVHKKDVQKAAAMLERKEEYACILAFDVRVDREAEQFAANEGVRIFSADIIYHLEDSFLKYREELRLKRRRQNEHLAIFPCKLRILPQHIFNARNPIIIGVSVEAGQLKRGVPLCVPSKDSIFIGSVSSIERNHEQVEIARTGDEVCIKIENTTGEAPKLYGRHFTHQDTLVSRITRETIDVCKAHFRNDLSKADWQLIVQLKKVLDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG07</accession>
    <name>A0A183HG07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA_6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6419</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006090">
        <property type="protein sequence ID" value="VDO46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG07"/>
    <dbReference type="STRING" id="387005.A0A183HG07"/>
    <dbReference type="WBParaSite" id="OFLC_0000641801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000641801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000641801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="158"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000641801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46027" checksum="F5FD16299804274D" modified="2016-09-07" version="1">MVEDEMRNTLAHLLNQSLSIFSKFDMNSIESQEYMTWLDQFPAQIIELTANIWWCANIEKHFAEEKTVEAVEVVVDKTLSLLADSVLSEQPAIRRKKIEALITEFVHKRDICRCLIQNKVASVTSFYWSRCMRFYFDPRKLDPHSCCVMKMANACFPYGFEYLGLQEKLVQTPLTDRCYLTMTQALNARLGGSPFGPAGTGKTESVKALGHKIGRFVLVFNCDETFDFQAMGRILVGLCQVGAWGCFDEFNRLEERMLSAVSQQIQTIQEAVRAGGQMQIDLIGKTLSVNSNMAIFITMNPGYSGRSNLPDNLKQLFRSLAMTQPDRQLIAQVMLFSQGFRMAEKLAKKIVPLFILCKEQLSDQCHYDFGLRALKYVLVSAGNIKRDEIQRMIENRSDVSICFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIB3</accession>
    <name>A0A183HIB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7227</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007405">
        <property type="protein sequence ID" value="VDO49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIB3"/>
    <dbReference type="STRING" id="387005.A0A183HIB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000722401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000722401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000722401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000722401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8374" checksum="7B2180413FD668F1" modified="2016-09-07" version="1">MNLLDPHQLMMNPFTYSVVDPATIALLNTTSGTQRSNAGKIVTTSSNLHSSNSSGNSSFRISDILDSNEDKANTSGENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIC7</accession>
    <name>A0A183HIC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COX2_TM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7236</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007414">
        <property type="protein sequence ID" value="VDO49943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIC7"/>
    <dbReference type="STRING" id="387005.A0A183HIC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000723801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000723801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000723801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF1">
        <property type="entry name" value="DOXA1 FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO49943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000723801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9064" checksum="455DA9A67A981433" modified="2016-09-07" version="1">MQWIGWFDAFRENGDPTFFGENRTPVVFDLQIFALSSIFITPFLAFLIILPGVRHYRLASTIAFVISVTVGAIILTIQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKA3</accession>
    <name>A0A183HKA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008582">
        <property type="protein sequence ID" value="VDO53121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKA3"/>
    <dbReference type="WBParaSite" id="OFLC_0000791401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000791401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000791401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000791401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6914" checksum="10396B37B25F7299" modified="2016-09-07" version="1">MDWLSLRQCSHNLALVRWHNFVIFKTFTSQSNPALCNTSNQWFLDLGRLQKSGCTTFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKK0</accession>
    <name>A0A183HKK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008753">
        <property type="protein sequence ID" value="VDO53634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKK0"/>
    <dbReference type="STRING" id="387005.A0A183HKK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000801101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000801101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000801101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000801101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30985" checksum="29FB041CE0F0D36C" modified="2016-09-07" version="1">MGKFKFYVFQNSERAVSVPASPLFIHGHSSVVTEKVLHSSRESCPPPVQKAVTEGDKKLGTTSLVTQLLTNKERIVKETETPPLMTTLPSVPQLPPSLPEPSVPAVRRQSYSNCPEISETRASTALMRTRNSYSRTFTRSRDSVRNQFPLNKLHNPGRRGKSGSRRGGSNSGSLGSNKDKHFVASKEKIEDSSDGSSVVPAVSNGPKQLENGPKLKQQSITKEEKRESVTPSTAMATTAKQSSQQHSDHQHSKKEKKKQVSSRFVYISKKFWSERNLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKR0</accession>
    <name>A0A183HKR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8071</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008856">
        <property type="protein sequence ID" value="VDO53911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKR0"/>
    <dbReference type="STRING" id="387005.A0A183HKR0"/>
    <dbReference type="WBParaSite" id="OFLC_0000807101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000807101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000807101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO53911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000807101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26537" checksum="490FAA7FA6C95B1A" modified="2016-09-07" version="1">EAQEIVKLVIDHENELKTLNGDLLSLRNELAKLYRTSINEINDCIRNDLEIIRRRCREIGNELANIENITLYLRQDILDSNTMSALNMLAESNIAEIFVDAISDFKHGEIELNKKIQEKEQAIQMSIKEIQHDLSRTADTLSTQIRQIKPELLHNLLKQYMGVNYHIIVQYTWYASLTLCAIFSLKALYFLFALCYGCFGRRPSDYRNDCCVRSTGSKLFIWLQKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLD9</accession>
    <name>A0A183HLD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8302</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009264">
        <property type="protein sequence ID" value="VDO55026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLD9"/>
    <dbReference type="STRING" id="387005.A0A183HLD9"/>
    <dbReference type="WBParaSite" id="OFLC_0000830001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000830001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000830001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000830001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17858" checksum="6DD8A647E3B35759" modified="2016-09-07" version="1">MEKLHNENESIIQSVLKDAKDESQKIRRTVRFKNEDKTYSANTTPISSPNSEISLHKNEPKMIINEEPRFSCPLPRSILRNFDEKSPVDVDALAATESDNRREIVPISEEAFTGKVMERYPPADNDTGTESVPVTMPSKDGSPRRISRFKMSRAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM02</accession>
    <name>A0A183HM02_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8514</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01009688">
        <property type="protein sequence ID" value="VDO56048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM02"/>
    <dbReference type="STRING" id="387005.A0A183HM02"/>
    <dbReference type="WBParaSite" id="OFLC_0000851301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000851301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000851301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO56048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000851301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16671" checksum="54C1098D58DEB919" modified="2016-09-07" version="1">MNSTLSDNISVQDDFVAYKSYENGHAFSVMPEYSFILTTEVKQRFLYLNNRIRQRSERRHALADAITFGVSMEPYLKLNIRRDNIIRDALDNLAAIAMDNSANFKKQLRIQFDGEQAVDEGGVSKEFYQLITNELFCPDYGLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM03</accession>
    <name>A0A183HM03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dus domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009692">
        <property type="protein sequence ID" value="VDO56056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM03"/>
    <dbReference type="STRING" id="387005.A0A183HM03"/>
    <dbReference type="WBParaSite" id="OFLC_0000851401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000851401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000851401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000851401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24519" checksum="B8F5DF5E91858BCF" modified="2016-09-07" version="1">FQIVQTCVSTSAIPISCKIRVLDKRENTLEFVKMLERCGVSAIAIHGRRRNERQGDVNRLNEIREVTGIVSVPVIANGFSSSIKKYDDIIKFREQSNASSVMLARKALSNPSIFRPNGSLSFEEEICGFLEKACKYDENFTSTKYVVQRILGSKQETDVRGRETVLAASVLEICKAWSISDIYYGYKNIRRRATQKRKFEVDGETGISFIDLTFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM62</accession>
    <name>A0A183HM62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8574</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009824">
        <property type="protein sequence ID" value="VDO56338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM62"/>
    <dbReference type="STRING" id="387005.A0A183HM62"/>
    <dbReference type="WBParaSite" id="OFLC_0000857301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000857301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000857301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO56338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000857301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22128" checksum="F8EEB10301F57556" modified="2016-09-07" version="1">IIKNCRFQTSSQSGDYAQFFNLVAKNNGNVTGRLEFKMQAHCDIDYSNFPDDDKSCCFRMKSILYPHYIRYYLAQGEDGLDLTKLRTNWHVRDANIKILPDEDDRKTQMLQICLQVRRRSSTLRIELTLPMMISSLLVVIAPFFGTFRDQINVKLFAIFIQLVSFTFLAIKAPQVGFGETVPHICGFLPIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMW8</accession>
    <name>A0A183HMW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8831</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010311">
        <property type="protein sequence ID" value="VDO57622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMW8"/>
    <dbReference type="STRING" id="387005.A0A183HMW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000882901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000882901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000882901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06671">
        <property type="entry name" value="PDZ7_MUPP1-PD6_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO57622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000882901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16345" checksum="312871951A0F5723" modified="2016-09-07" version="1">MNSSIPEDYASNDRLLCKKEITKAKKKLLKEPARLNRLNFWGQTRTVILDREPNQSFGISIVGGRVEVSHKSGQPGAKSTVSGIFIKSVLPNSPAGLSNMMYMGDRVLSVNGQDLRDATHEQAVQVIKNAKNPVKFVVQSLHSFPPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNS6</accession>
    <name>A0A183HNS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010899">
        <property type="protein sequence ID" value="VDO58854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNS6"/>
    <dbReference type="STRING" id="387005.A0A183HNS6"/>
    <dbReference type="WBParaSite" id="OFLC_0000913701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000913701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000913701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000913701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19794" checksum="534136195FB57178" modified="2016-09-07" version="1">MNYVVLSADGMIAACQDRQLRIYSFQGKLVKQIKGAAGDDGQLTRVRLDPSGIYAAAVCTNRNVYIIDLATGEFAAVLTGQSDNITDIAFSADCRRLYVVSYSGCIFVWRLSNFLVNKMMARKSQAVKNIGILGIEKFCERSETPDSLLGSGSDAAGDEHMEYNRNAKVKFYYLFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ98</accession>
    <name>A0A183HQ98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA_6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9661</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012096">
        <property type="protein sequence ID" value="VDO62261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ98"/>
    <dbReference type="STRING" id="387005.A0A183HQ98"/>
    <dbReference type="WBParaSite" id="OFLC_0000965901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000965901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000965901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rege-1 UBA-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000965901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12849" checksum="C719856F64CECE80" modified="2016-09-07" version="1">MLESQDSCYSSCSEESHSPFPRELPDNITKDIAQLSVTDTESNTANRGNEQQQQLLQNIDFATRLGYSMEQLEIVLGKLGISARQVGKLRKFKFDWFHWFFIEFQLVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC1</accession>
    <name>A0A183HQC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012143">
        <property type="protein sequence ID" value="VDO62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC1"/>
    <dbReference type="STRING" id="387005.A0A183HQC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000968201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10835" checksum="BB2C3AD81E762898" modified="2016-09-07" version="1">MGGISQQNNEKIAVIEAWKVVKILRSETTMRTRFNIVSIDALCKSSYLSIVLEVAQDMVYAIITQKSATATDIGCRVFYLTSFSVPELIVASLSPNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRB0</accession>
    <name>A0A183HRB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012928">
        <property type="protein sequence ID" value="VDO65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRB0"/>
    <dbReference type="STRING" id="387005.A0A183HRB0"/>
    <dbReference type="WBParaSite" id="OFLC_0001002101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001002101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001002101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001002101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14793" checksum="224FA60473012A5D" modified="2016-09-07" version="1">MKDNASKPESKSDSLFDSTNIDFNLLQSVKVAVTSESTTIEMEHMKMDHVSKGCLTNASSHSMSNECCSPQNLSHDKSNQSKKCDLIEQKLVTDKRSIAADNVIVPKCPEISIQFSLVDSLISVDDLLILCKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSE8</accession>
    <name>A0A183HSE8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10413</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01013846">
        <property type="protein sequence ID" value="VDO68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSE8"/>
    <dbReference type="STRING" id="387005.A0A183HSE8"/>
    <dbReference type="WBParaSite" id="OFLC_0001040901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001040901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001040901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001040901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19556" checksum="15E38C8B302D0A32" modified="2016-09-07" version="1">MNMNSKASRSEASDYVIEIGPGPGSITRAILETNCQRLDVIEIDHRFIPPLEVLKEASEERMFIHRDDILKINLEQIWSHAGVERVAWEEDRLPKAHIIGNLPFNIASPLIIKFLREMLYRRGPWSFGRVPLLLTFQMEVAERLCAPVDSPFRARISIMSAFITEPKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSM5</accession>
    <name>A0A183HSM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014035">
        <property type="protein sequence ID" value="VDO68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSM5"/>
    <dbReference type="STRING" id="387005.A0A183HSM5"/>
    <dbReference type="WBParaSite" id="OFLC_0001048601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001048601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001048601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001048601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23092" checksum="E2D57782E3312B44" modified="2016-09-07" version="1">MDESEKQHMQHSYNDVIRHTALLMFHSSIFKIIQYKSIVVAAYHGWPGAICAWVGIQNTLLNNNNYQKELAGDDLEAVRFETFISSLNYTQLAILLAIRNGQYHMLRYLPTISISDSFYHLFPDGRVRYYFFRQLTNFPASEHLLNDKLSDYLDSIAQALLVWMPKLDIQRLQREVEKSGDTKTRNYLKQILNKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSW1</accession>
    <name>A0A183HSW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014226">
        <property type="protein sequence ID" value="VDO69577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSW1"/>
    <dbReference type="STRING" id="387005.A0A183HSW1"/>
    <dbReference type="WBParaSite" id="OFLC_0001057301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001057301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001057301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001057301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25099" checksum="410BF474CBC7CDD0" modified="2016-09-07" version="1">MAKRCSQPPSSASTSSAMPQTGLPSMITLSPRQHFTGHHHSSRLLNSQPEKLEETVSRTARVPPPKLLPSAVHRTDSFTTTAQLPAQMLPSSYTYSMPRSITQRPVPVSSFPGPSTAPDYLPESSSYGAFPGNFGLSQFRAPPGISRPLPINQRSLSDVAGYSMHHSLCSPPGALDPRYMLRGQSAWHPIDPSSSRSNSLPRRRAISGTAVPPRTVKWRNDVIDGASLFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSZ0</accession>
    <name>A0A183HSZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014314">
        <property type="protein sequence ID" value="VDO69852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSZ0"/>
    <dbReference type="STRING" id="387005.A0A183HSZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001060201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001060201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001060201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001060201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13008" checksum="3196C0B95EDE766A" modified="2016-09-07" version="1">MISDKQRKAIDQYYHSLKINCEMLASLCEVMGTKKIITNAYDSVWNVLMRSRHKGVVDDCAICFNRITACCMANDLLDVVWQYFEKVRLSVFSTCQYSLFLQIFLSNFISVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTI6</accession>
    <name>A0A183HTI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014821">
        <property type="protein sequence ID" value="VDO71409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTI6"/>
    <dbReference type="STRING" id="387005.A0A183HTI6"/>
    <dbReference type="WBParaSite" id="OFLC_0001079801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001079801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001079801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001079801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14396" checksum="49CAA4CAB34BFF9D" modified="2016-09-07" version="1">MDLFALHQFFHLAVGQKKKAIHQNPKLFYDLLFNSFELIELFDVYEDVNIMKRNVSNDSAVDNTMEIDYVNVGTVNMVPLQSTHEIDPNLVRDLNAQDLNPRDFDQYLQLNDNRSSATVAKPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTL0</accession>
    <name>A0A183HTL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10825</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014887">
        <property type="protein sequence ID" value="VDO71644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTL0"/>
    <dbReference type="STRING" id="387005.A0A183HTL0"/>
    <dbReference type="WBParaSite" id="OFLC_0001082201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001082201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001082201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001082201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12066" checksum="809E3128F687E780" modified="2016-09-07" version="1">MCRSLQRSTFLNLRKLSGGLAVGGLIGFIILEFGFEDLEFCIVAIVMALGNKNKKKKKGLVAALSQKTFKKMQSSFWQAVEPKAKTSRPLKVIFFFLKNLKFALFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUH4</accession>
    <name>A0A183HUH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11136</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015690">
        <property type="protein sequence ID" value="VDO74165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUH4"/>
    <dbReference type="STRING" id="387005.A0A183HUH4"/>
    <dbReference type="WBParaSite" id="OFLC_0001113601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001113601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001113601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001113601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12608" checksum="9096EC0A2833A619" modified="2016-09-07" version="1">MCWSKSHERLYAFNPTSQGSSVFSELFEKAQCCVNFWKAVLAKKCSPNSSDTSKNDCYQWFWEWTQSFMVENYGPRTVLEAEEHPRGLTLRSIHAITQQQKNSVCHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUP3</accession>
    <name>A0A183HUP3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum lectin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ER lectin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS11201</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015881">
        <property type="protein sequence ID" value="VDO74680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUP3"/>
    <dbReference type="STRING" id="387005.A0A183HUP3"/>
    <dbReference type="WBParaSite" id="OFLC_0001120501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001120501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001120501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO74680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001120501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22111" checksum="8149F2C260BB5797" modified="2016-09-07" version="1">DDKNFDERNPPKRKINNKEQPYYPITYRQGTVCDLTGKPRNTIVIYACDPDARDQIFSFAETASCTYEMIVFTKQLCSHPSFQPLSTINHEIVCYSKDPHKEYPKPKQLLQLERENAATLEKEYKSTIQLDKPSIHIEKPSVHIDIDEEGNEEDENEDYGDEFDTVLITAKQAPPKSDSLQHSRLIFLDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUP6</accession>
    <name>A0A183HUP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11210</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015904">
        <property type="protein sequence ID" value="VDO74781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUP6"/>
    <dbReference type="WBParaSite" id="OFLC_0001120801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001120801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001120801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001120801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5907" checksum="F08CEAE83089C657" modified="2016-09-07" version="1">MTRKMKRKKMIINFWNYHHNKMNRSNNNNNNNNNNNKNSNNNSKNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUW3</accession>
    <name>A0A183HUW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016100">
        <property type="protein sequence ID" value="VDO75276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUW3"/>
    <dbReference type="STRING" id="387005.A0A183HUW3"/>
    <dbReference type="WBParaSite" id="OFLC_0001127501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001127501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001127501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF291">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001127501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12781" checksum="9D906A0F79694FBD" modified="2016-09-07" version="1">MSRNLHANGDARLLLDLFCRYQAKINRNDKSTKRWDHALLFTGYDLYRKKDRTLAGYAPINGMCSVKNSCTISEGLDFSAAFIVAHEMGHKFVFVNFARSLNVYSLDTVILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUZ5</accession>
    <name>A0A183HUZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016195">
        <property type="protein sequence ID" value="VDO75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUZ5"/>
    <dbReference type="STRING" id="387005.A0A183HUZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001130701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001130701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001130701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001130701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4531" checksum="DC8175F8D1D82B6A" modified="2016-09-07" version="1">MEDNLLPGPQGKIPKMYEVDKERHTESYVTAVRGHYNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVK6</accession>
    <name>A0A183HVK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-synt_2c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016697">
        <property type="protein sequence ID" value="VDO77009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVK6"/>
    <dbReference type="STRING" id="387005.A0A183HVK6"/>
    <dbReference type="WBParaSite" id="OFLC_0001151801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001151801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001151801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-tRNA synthetase class IIc N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001151801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13083" checksum="DFEE70416D3E0B24" modified="2016-09-07" version="1">MLSSLVPDFVNHLTSLYDSVAACETIIAETVMSEEQLFWKSYDKGNKLLQQNIASHSHVLPGKIAWMLSGTYGLPLAITEKMCNEKGLKVDLDGFHQCLTNFQVIFLYRYFVFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWD5</accession>
    <name>A0A183HWD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11797</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017536">
        <property type="protein sequence ID" value="VDO79326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWD5"/>
    <dbReference type="WBParaSite" id="OFLC_0001179701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001179701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001179701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001179701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="4880" checksum="2124F199660ED51F" modified="2016-09-07" version="1">MGDVSCYMGAPGSGAPTGGAPSGGGGAGGGGGGGGGGGGGGMGGGGGGYGYQYQQEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX05</accession>
    <name>A0A183HX05_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="3">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12016</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Endoplasmic reticulum membrane</location>
            <topology evidence="1 3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018100">
        <property type="protein sequence ID" value="VDO81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX05"/>
    <dbReference type="STRING" id="387005.A0A183HX05"/>
    <dbReference type="WBParaSite" id="OFLC_0001201701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001201701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001201701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OST48 N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001201701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8974" checksum="BE503B7C049A312E" modified="2016-09-07" version="1">MIDFRKNSVTLTIHTFIVEFGGTINVKAITSFIDNGGNVLVTAGPRVGDALHDLAAENGFEFDENRTAVIDHMNYDTVLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYE2</accession>
    <name>A0A183HYE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12504</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039857">
        <property type="protein sequence ID" value="VDP11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYE2"/>
    <dbReference type="WBParaSite" id="OFLC_0001250501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001250501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001250501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552681" evidence="4">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001250501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12702" checksum="5851CA37A61FC059" modified="2016-09-07" version="1">MMYFTLLTLPIFLDNLLDAARMPDPPVFTDVQHYPCLCYLPPDSGLCPVAETNDDIIARDKLQVRYYFDPVTEKCYPFGTQGCGGNGNRFENLSKCQSICKKHQQILSRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYX4</accession>
    <name>A0A183HYX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039904">
        <property type="protein sequence ID" value="VDP11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYX4"/>
    <dbReference type="STRING" id="387005.A0A183HYX4"/>
    <dbReference type="WBParaSite" id="OFLC_0001268701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001268701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001268701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001268701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57697" checksum="15D27742CB19810C" modified="2016-09-07" version="1">MSLDNGNIAPDPHYRNHDFTTFRHCKTKADTTTDLGEECTDFYNIKKPTSASSVTLKQTSTPSPSYPSANSWPGFGSRCTHNGEDIQVPTVDSIKSPCAAKCELPFRQQKPGRHVYVFSSKMANDAAIGVRQKKYDSIIAWHEANCRPSTSKCEFTEDCQAVPISKKKRRSVVLTPKFQQDYRNGSPMRSCGTPSICSPSSTMLPTPSQTSGESNGNPPSNPSETPSGELLNPDDHTDIGDNPLRRMERMTQDSLFEPPSKLCRTSTDNSQPARKEQDRNAKLEKMRTLEQQIMYDKAKTEWDRMMHEHEAIKMTRSHMPSLIPPCSQASVPAPYPCTFANQNGMLMQGSCRRPIYSQPLQSTEPPSSMSNVSINTPMMASLPQTSGPNMPMSQPLRPSLNPSACSMQYSQCGFMCCPYPPNTYPPPQGYPHINGTASSCFPSNFVSSNGNMASQPRDYGMYQQEVRTVCSQEKLECEMWNRQIPTVHADFSNTFPDQKVQYHAVSNVLCIQFFVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH4</accession>
    <name>A0A183HZH4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress-induced-phosphoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12886</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039964">
        <property type="protein sequence ID" value="VDP12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH4"/>
    <dbReference type="STRING" id="387005.A0A183HZH4"/>
    <dbReference type="WBParaSite" id="OFLC_0001288701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36752" checksum="D0B4EA04B978F0A9" modified="2016-09-07" version="1">MAEALKEKELGNAAYKQRNFDEAVKHYEKAIELDPTNIVFYNNKAAVLFEQKKYDECIELCKKAVDIGREQRADYTHIAKAFSRIGNAYMKLDQLKEALTYFDKSLSEHRDPELVKKKKALEKELAEKERLAYIDPEIAEKEKIKGNELFKRGKYPEAMKHYNEAVKRDPENPVLYSNRAACYTKLMEFQRALEDCDTCIKKDPTFIKAYIRKGAALVALKEYGKAQSAYEAALALDNNNQEARDGLMNAMSNNNEDPDAARERALRDPEVQEILKDPGMRLLLEQMSQDPGAVREHLQNPDILRKLMKLREAGIIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZX5</accession>
    <name>A0A183HZX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13037</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040021">
        <property type="protein sequence ID" value="VDP12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZX5"/>
    <dbReference type="STRING" id="387005.A0A183HZX5"/>
    <dbReference type="WBParaSite" id="OFLC_0001303801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001303801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001303801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001303801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39758" checksum="67E8F099AFD9BD64" modified="2016-09-07" version="1">MDSLFYGDLEYDGSSFPQSPKKNRYGTLNGKLNGIMRDDKEQNLNENGKSSNFEMRSILKNSNHSIKYNNYHTPLTAQYECNDMDHKVSYFGRIIRPCLAEFVAVFLCILIGKVMESELSVHITASSTERIILQALTDSVIVLVMIMAFQTVHLNPVITLAEFFALTTAWPMCCAMIIMQIFASVTAIAAFAMFRSGDSELQMPTIIPNITSDRVDATYHLILSQFIGTLLVVIIHLLITTRTGSGLTALAQPGDSPLSVAAAVFVSSLLWGEIRKRPAEMKGQHLLNSTVGWNPLLAFALASYRSIDCNFAPLQMQGVFWIGPCLASLLACFLYRLLFATKKSRLKCTTWNESDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0K8</accession>
    <name>A0A183I0K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040118">
        <property type="protein sequence ID" value="VDP13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0K8"/>
    <dbReference type="STRING" id="387005.A0A183I0K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001327101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001327101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001327101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001327101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17159" checksum="A4D8651BD59C9975" modified="2016-09-07" version="1">MLSLVDYTGSDDEGTDDSRNEDCIHAEVVLNPTKRLSKDDRMRDGFYDQGNDPIVEQDDSITNAGEVSSILTNLPPSILVTDKCVQKENELEDLVKRKDWELKLAKKAERKRKHHLKHFINNSSKNYYLRFFFLICYRTYMSLHICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0W8</accession>
    <name>A0A183I0W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040171">
        <property type="protein sequence ID" value="VDP13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0W8"/>
    <dbReference type="WBParaSite" id="OFLC_0001338101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001338101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001338101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001338101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36111" checksum="161B9D79B7817D87" modified="2016-09-07" version="1">VGYTKLRVRLAELASSSEFPNSGLFGPSKVTLRVERLLFDVIKKAEMVIARQSPIVLNERPGVRYLCCDRCFKCNGRNLIAREIWPSDGGYIELNGKELKRFIINNEVRILNGSKVSRYVAGGSSREYTIDSGIKRTSKDDSALTTESSIKSFTSIFRPDFCEVLQHKAGRNPTEFNSMSVGTDSNGIMKAKQQFHKHFRDSSSEISITSITESPETLISSKTTDLTNRSFDESSSKPTNNKLPVGTYNFMQNSNDQPVSAMKPDGTIVIPGVVYVDNFESLNGVVLKVKVLAKSPNESRRLNIKIGCSDSSQNGRNEWSRNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1K2</accession>
    <name>A0A183I1K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13614</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040294">
        <property type="protein sequence ID" value="VDP14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1K2"/>
    <dbReference type="WBParaSite" id="OFLC_0001361501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001361501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001361501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001361501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7755" checksum="C72204265147C2F5" modified="2016-09-07" version="1">MELKEKDKEVLNNKTYCSHQQQINEKEEDEVTQEENQAIDKMTLLHQALSQASVTRAKRCKQTSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I200</accession>
    <name>A0A183I200_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS13762</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040380">
        <property type="protein sequence ID" value="VDP14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I200"/>
    <dbReference type="STRING" id="387005.A0A183I200"/>
    <dbReference type="WBParaSite" id="OFLC_0001376301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001376301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001376301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDP14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001376301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32236" checksum="B2388573EC2960CA" modified="2016-09-07" version="1">MCQFTLKPITDTVTRFCKNIECEDKDMGIVQVYSTNGNKIAGSTSVQQLLLRGNFELHISDHAYIVEVPSSTDFIAGIKTDSDIMQNFDDLRSVVASLYAIINVEEFKAFRERVLIEEYENVKAELKPLIQAKSEMDAICKKRAQRMLWLALSGMGFQGGFLARLTWEYSWDVMEPITYFATYATLIASFAYYLYTNQYFDYNDHKRRAMTLYFHKKAAKSNFDISRFNELQSMANSLKHELKRLRDPLYQHLPATELASLLRKSEKMRHTNSTKETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I288</accession>
    <name>A0A183I288_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040430">
        <property type="protein sequence ID" value="VDP14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I288"/>
    <dbReference type="STRING" id="387005.A0A183I288"/>
    <dbReference type="WBParaSite" id="OFLC_0001385101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001385101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001385101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001385101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="787" mass="90237" checksum="E74878B85C987EDA" modified="2016-09-07" version="1">MPGGSKNLRSALRRRTATIVHPLEEPSEDVDVGGGIGDNGVHELVDVEGDTAPSFPQETLPTTSKIKLCKREIDEDDDENQPVMKIRRITTPAYAIRRIDRRIWPNEIVRKNYSYGKSTTYSVRKEQELAPNPNNPHFCFTGHQRLYPYRFYLDLIRRAKRDPSIISLDMPKLRPVGGTIIVYDCHGIDQNRALHNDGYRWGRSKGVKLIQSVGNRLVRTYHFLYDPNNPAGDPSFKKYRFSLKGENYGIMVMHYIGDEKHAAEVSARCMRNNDPMAMLAYSEAQQGVEDLHSLHMLPLPLLNEHSSEEERNKYRQTLLSNIQSLQRQLLYENEETFLERVEFDDSGVSVIYLFCYALVEQLIAVAGYLQQGTPFRTVQLFYHTEPVTVDYHVSTLSFMHPFFEGEVNGEAKWMFVIGDQVLPIAFMISSTASPDRCDDHDSFLSTLYDRFSELLNGRFVIITGQSLSFTPEAFPIAEHIRCWDDFKRVKLGYIETLFGGANLNEYASDMNILMSCTYEKLFDEMWGKISACKRYTERPDVYSYFDNVWNDFKFTSSIWHLKNCGVPDADKGVTWRPCKGLSKLVSQLCDSNALLDTIVISLFLLSNAYRRLFIAGLHQSGAWRLKKCYRERFQQSHLKLPKLPYAPAMENIVMTAFNMCPNRPYKRLSHDGVNDNSFSTCLDNEYQNHTSSLSGQIDLPSTSTVFWEGHPGSNFDFIIDADDSRLPFSRNAYVRLVSPMTFAVRARDGSPHVVEATHRDDLDSLQWYCSCGLRQRCSHIASVMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2V4</accession>
    <name>A0A183I2V4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14066</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040573">
        <property type="protein sequence ID" value="VDP15408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2V4"/>
    <dbReference type="STRING" id="387005.A0A183I2V4"/>
    <dbReference type="WBParaSite" id="OFLC_0001407401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001407401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001407401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP15408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001407401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37863" checksum="DEF9E322D9915907" modified="2016-09-07" version="1">MIYWPETLLDMVIAQIHYAPDSWKGKAHTDTVRKEFGHLFELKARFLLEELLSPILTPFVLLFWIRPKAKELVDFFHNFTVSVEGLGDVCSFAQMDIRQHGDPTWSFDELTKEEVANIHGRVHANDGKTELSLIHFASNHPGWKPPACAARFLDDIRDRMAQDMNALKEGIVDDNILLNSLHSFHPISEQQFRKFVGRQPFAASLRDPNLFDTAANVYLYGESKFRYDFIAYLRNLHTHCDNHRPEIIPSPVTMTCQYVAQISPISANIAPTVSGIIRGSDDATIETAGNVWGVPAQSTISPLQASLSPRSEDEQLQQDGNEPPPLKLSHHILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2W1</accession>
    <name>A0A183I2W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14073</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040578">
        <property type="protein sequence ID" value="VDP15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2W1"/>
    <dbReference type="STRING" id="387005.A0A183I2W1"/>
    <dbReference type="WBParaSite" id="OFLC_0001408101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001408101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001408101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000167">
        <property type="entry name" value="Putative prenylated protein tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001408101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21584" checksum="536E1B71CB1479DC" modified="2016-09-07" version="1">MITGKRMESSTARRLTHTYFKPAPSEIQYGKMRFLITDRPSDLTINTYIEELEKHNARAVVRVCEPTYATTPLIVNGIDVLDWEFDDGSAPPPELITKWLSLAKESFKLYPNQSIAVHCVAGLGRAPVLVAIALMEAGMKYEDAVDLIRRHRRGALNQKQLNFLQKYKSTGQLRKLRYNVEGKPARCCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3A0</accession>
    <name>A0A183I3A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14211</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040677">
        <property type="protein sequence ID" value="VDP15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3A0"/>
    <dbReference type="STRING" id="387005.A0A183I3A0"/>
    <dbReference type="WBParaSite" id="OFLC_0001422001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001422001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001422001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF44">
        <property type="entry name" value="LITAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001422001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13043" checksum="A87AE23ADD9EEDCF" modified="2016-09-07" version="1">MPLEKSQQTANTLHRSISQTPSMLVNIKEYLSDQPQFIDCPCCKVHGTTEVKFTIGFFTWISFLIILMTGIFILPLFFLWVPFFVDTFKDAHHYCSNCKVWIGTYRRLGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3E8</accession>
    <name>A0A183I3E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="21">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">OFLC_LOCUS14260</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="21"/>
    <dbReference type="EMBL" id="UZAJ01040721">
        <property type="protein sequence ID" value="VDP16223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3E8"/>
    <dbReference type="STRING" id="387005.A0A183I3E8"/>
    <dbReference type="WBParaSite" id="OFLC_0001426801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001426801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001426801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000017">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDP16223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001426801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45455" checksum="B341E4632832DD32" modified="2016-09-07" version="1">MIIVIFIAGAIEASQSSLLKIWKKKVADISVFETNIRFIGGLLAAYALTGDKMYVQKATDVANILLPAFETPTGIPYALVNPVSGRSHNWDWTNGGFSILSEFGSLQLEFDYLSQLTQNFIYSSKVSRIREVVLSVKTDDGLYPNYLHPKSGKWGPKHVSVGALGDSFYEYLLKSWIRSGKNDTVYKEMYDLALKSIKKYLLRYSRQNHLAYFIELKGKREVHKMDHLACFIVGLLALEALNENDIKRRSDTLKLAEEIANTCHESYIRTATGIGPESFRFTNDIEGMAISDKEKYYILRPEVIEGWFYLWRVTGKNKYREWCWVAAKNIEKYCRTTGGYSGIKNVYNAEVVHDDVQQSFVIAETFKYLYLTFSNDSIMPLNEWVFNTEAHAFPIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3J5</accession>
    <name>A0A183I3J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14304</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040751">
        <property type="protein sequence ID" value="VDP16423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3J5"/>
    <dbReference type="STRING" id="387005.A0A183I3J5"/>
    <dbReference type="WBParaSite" id="OFLC_0001431501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001431501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001431501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001431501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9355" checksum="55F2DCE1DCC41F27" modified="2016-09-07" version="1">MAAHPVGVSSFPQPPEYARQYTDANVAKKNVLPPPIIPSEFTVFGEEYNFEEVSIFFYPKRFVFFFFFFLLNLDYFYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4L5</accession>
    <name>A0A183I4L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14677</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041076">
        <property type="protein sequence ID" value="VDP18186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4L5"/>
    <dbReference type="STRING" id="387005.A0A183I4L5"/>
    <dbReference type="WBParaSite" id="OFLC_0001468801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001468801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001468801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001468801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20258" checksum="AEBC570262E1D277" modified="2016-09-07" version="1">MEVEDEGRPYSDVVLTISARDIKDVDTDSYSDPFCIVSAANAGLVRCRTWKEIGRTEVINNCLNPDWATKIHIAYYFEEQQRLLFELFDKGPGKEKTELGSASLLLHEILGAKYNRKTVKLYKDGKNYGNLIVAAEEMTKGRQESVYFVCSATKLDKKDFLGKCDPFLKISRINKDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4M8</accession>
    <name>A0A183I4M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3385 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041088">
        <property type="protein sequence ID" value="VDP18257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4M8"/>
    <dbReference type="STRING" id="387005.A0A183I4M8"/>
    <dbReference type="WBParaSite" id="OFLC_0001470101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001470101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001470101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase mTOR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001470101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39696" checksum="B669CD8018245B8C" modified="2016-09-07" version="1">MQMLRDDALSHLHRDITQALLTIFGSLGPSCTLYVIPRLFEVIQTATRPDLKQFYLQQLANFIAIVGGSMKPFMSKLFSLVRESWSEDVSMRLTIVNVMQQIGAAFGASFAPYIPELCPYLLNIVQSDRSKDRAITCAVFTCVQSISMCLAPHIHLVLPPILFLLDDRTVKVEVRKIALDTIYQMAGTICIRDHAPRIMQVWLRVISVHALQQKLLLLLVVIVRQMWRQFLVFRKSVDYALAQYGLHCDEYLKLTVQLDDGSVASPSYSPTVRVSSNHIKQFITTARHEKGQRINFDVLKKTWTTAQLVSKEDWDQWLVLLRIQFIRQSPSAALRACAPLADVHISLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Y0</accession>
    <name>A0A183I4Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14791</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041204">
        <property type="protein sequence ID" value="VDP18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4Y0"/>
    <dbReference type="WBParaSite" id="OFLC_0001480301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001480301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001480301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF3">
        <property type="entry name" value="NIDOGEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552771" evidence="6">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001480301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33634" checksum="5BE34DE086F840F2" modified="2016-09-07" version="1">MKTLLAQLALVVLYYSIIVTTETSDVDLCKRQPFRGRCPAAKGKGLTRSQFVLRYYLRDNECAQISGHCPDDENEPMLYRYKEDCEKACIKKSHRGITNSITNANDNLISESDSSLNSKITDXXXXGITNANDNLISESDSSLNSKITDSNTVEQVSITSESFSENDATTTSTQQPVFTTRKTTSHKLLTECEKQRQGIESGLIASDFTPICTADGSFRPLQCESKGERCFCVNRNGDKIPNSYSNSTKKPDCKRIMKARKPTRHECLAPMDSGPCTAAITRWYYDDKEKHCIQFEYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5H6</accession>
    <name>A0A183I5H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14988</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041455">
        <property type="protein sequence ID" value="VDP19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5H6"/>
    <dbReference type="STRING" id="387005.A0A183I5H6"/>
    <dbReference type="WBParaSite" id="OFLC_0001499901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001499901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001499901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001499901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12331" checksum="8755EAFA9D26882C" modified="2016-09-07" version="1">MAAFGVQLERSDRNGILNIDEIAQYQAGRYISSNEAVWRILSFPIYERSPAVVHLAVHLENGQRVYFAAGNVQQIALNPPATTLTAFFTLCQRDPFENTAKYGSAYILHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5X4</accession>
    <name>A0A183I5X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15136</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041665">
        <property type="protein sequence ID" value="VDP20548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5X4"/>
    <dbReference type="WBParaSite" id="OFLC_0001514701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001514701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001514701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001514701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31145" checksum="1FC03A457C4EECB0" modified="2016-09-07" version="1">AGNDQTFEVPGTSTINTRDVSAASSLSVPSLCNSIIEAGTQNPLRNVSLVNTNERPMEMASGSNNHIPSNGTMASDKIGRLGFRPKLNRELDHPGMLSGMPQQPPQPPMIGMMRAQQRFGMPSFRDSVPIMDNSRGAPFMDERGLSFPNSRIVSLYDDGRLPFHEYEHPQGDEAIRIRHVWSTRPSATQRRMLHQGVFRDRKIQRAVAGTFANRNYGEMRDRSRSPHGGPKPLVANSSCETGATTTTNPNVYATHASSNNAEENNVMLIDENSEPGTDKINQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5Y8</accession>
    <name>A0A183I5Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15150</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041679">
        <property type="protein sequence ID" value="VDP20582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5Y8"/>
    <dbReference type="STRING" id="387005.A0A183I5Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0001516101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001516101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001516101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001516101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18463" checksum="7F3794D38AD03802" modified="2016-09-07" version="1">MDDHQSLINKGTEGRNSDWAVFECGSHETTAFVRIARARLSGTPVVVSTAGHDLTCAQYCRNNIEPTTGAQRVCASFNFDGRETCYFFDDAATPAGTANLAPNPSANNFYYEKTCIPGVSAHEACTYRSFSFEHTRKTALEGFVRKSVQVLQLILCFFESIRIKCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I611</accession>
    <name>A0A183I611_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15173</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041713">
        <property type="protein sequence ID" value="VDP20685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I611"/>
    <dbReference type="STRING" id="387005.A0A183I611"/>
    <dbReference type="WBParaSite" id="OFLC_0001518401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001518401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001518401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001518401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24295" checksum="740983FC79F3B28D" modified="2016-09-07" version="1">MGILGCQWCTFESDGQTLLLNPSCVSTDECFGGTKGRRIRGFLESESQLVPQWSVGAPVGPVAAGIMSVFLIMVITMYCYRSQVNRLVETNSLTDSFGVPLCGRNFEDDDFQFDHDGSGSVKEKAVALIQLTSFERMSNPLAAVRPQYRVSPRTESSDQGYSTMTDRMQGDESECATSNVNISRETGKTMLTTLDTNDNGCSIIVTTEADIHQAPRNLLMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I797</accession>
    <name>A0A183I797_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042455">
        <property type="protein sequence ID" value="VDP22828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I797"/>
    <dbReference type="WBParaSite" id="OFLC_0001562201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001562201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001562201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001562201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6401" checksum="2BC224548D78DF3D" modified="2016-09-07" version="1">MEEKDATTTDYRKTSSAQSGYRKRVMRRVNEDSHTQEPVARLAVVYTNLYLVTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7M5</accession>
    <name>A0A183I7M5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS15737</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01042741">
        <property type="protein sequence ID" value="VDP23539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7M5"/>
    <dbReference type="STRING" id="387005.A0A183I7M5"/>
    <dbReference type="WBParaSite" id="OFLC_0001575001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001575001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001575001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="14">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="12">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP23539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001575001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="23868" checksum="50585210866800FC" modified="2016-09-07" version="1">MNNNASREGASISSTLPTSGTQGNNQDPGRRKLIQLQLVLLLHAHKCQQRERSAARDGANGRYTCTLQHCSTMKGVLQHMTTCNSGSACNYPHCPSSRQIISHWKNCVRDDCPVCTPLKSRQNVAQTVDRRAVPGTEPFGNSGAGSVQQVPCGPGNASDIDNVGMPNRINTQQQQQPQQQQQQPGHGTALPPNTNSQNMSAYDSSGPTSINAFLIDFNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I838</accession>
    <name>A0A183I838_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS15900</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043189">
        <property type="protein sequence ID" value="VDP24727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I838"/>
    <dbReference type="STRING" id="387005.A0A183I838"/>
    <dbReference type="WBParaSite" id="OFLC_0001591301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001591301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001591301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP24727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001591301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19944" checksum="978CE01637BCE41F" modified="2016-09-07" version="1">MSKGILLGDKFPDFQAETNEGFISSFYDWIGKDSWAILFSHPRDFTPVCTTELARLVQLAPEFKKRNVKLIGLSCDSAHSHSKWADDILALYKMKCVGCDSEKKLPFPIIADENRSLATELGMMDPDEHDEKGNTLTARCVSFVNSFEFHFHELLPFKKLNLTYALIKSSILYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VA09</accession>
    <name>A0A3P7VA09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005207">
        <property type="protein sequence ID" value="VDO44440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="83" mass="9578" checksum="8884FAC29C4FCFC1" modified="2026-01-28" version="1" fragment="single">ERNFRIKKTTVTISRYGQGKFLEKDTVHFEVSLGLKIMKLVKEYSILNNRSAVEAEQIIPTAKTMQMELLNRDENEQCSLMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VCW8</accession>
    <name>A0A3P7VCW8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005729">
        <property type="protein sequence ID" value="VDO45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VCW8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="74"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="182" mass="20080" checksum="E3FA680D543BD43C" modified="2019-02-13" version="1">MLQITKANRAYEILLTGEGESVLVIPYAVIKTTGTFKCVAENSEGSTAFETQLTVHSLVSRKSSQSQQQEKLAPSFTMDLTDIGVAIGHPVTLKCCVQGIPEPQLKWVFINDSQQTSVMRTTTDSAWVQYRQGDTCEMKTESVVKTQQGTYQCIATNEHGKAMTQCYLLVGGINFCMIKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VME8</accession>
    <name>A0A3P7VME8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007140">
        <property type="protein sequence ID" value="VDO49201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VME8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="125" mass="14567" checksum="7ACB601F0162B88C" modified="2019-02-13" version="1">MLFNNSLHFQGLHLTRFYSKNINLTRPIQDDRSAEYYLPSNIEFLKRGKELCPHVKTSISDKDSQDVTLDDFQDFQDFFDEKSDAERQSPKLPIIVGAGKRPAISSYLLLFILAILGYFFNLWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X3Y9</accession>
    <name>A0A3P7X3Y9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SET domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000038">
        <property type="protein sequence ID" value="VDO24748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X3Y9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15566">
        <property type="entry name" value="PHD3_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="488"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO24748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="82710" checksum="A3B1D1006075EA18" modified="2019-02-13" version="1">MALSDKESDDSKEDDSKEDRWGRRQFSVGKRECFICEKMNGIDDRKFVRRFSTSVESNYSGEHATTIDRDASVFGQNKIRKCSFPSCTLRFHENCFLVFTEGSSPNGPSDFLPRIHILDRNGDLCINLKDSKKWICPQHECNFCHQELLRTRAFQGKFIRCVKCVFAWHRSCVIVGSLHMDQKRDRYVLCPRHNSVKRVSKRNIPYCIKCENSFDNESQEMACDFCIRSFCHNCVRKNKTKEVKVESNPFVCDFCRCFDFPRIGDYVLATYKSKFWPARTLHADLLPVSLYSVNNFIEKLRKPGYVLVEWIEGLNVPNYDVVTCRDLVSFPKTLSCSFWNRMKIHANIYKATEAIYANSKAVGIKRPLPREVKAEILPKYTRIKTNINMRLARARSNIAEFGHCVCESINGKRCTVAHGCLNRISMTECPEDCDATYFERRNALTGGTKRQVLKRTAGVHGNENSLLLSQKMCTNNFLRYHDTNDDKLFMEEKPTKLKGFGAFAKCDINESTDLTEYIGQVITKEEYLEKLRFRSLFNDLEASYFGMQLTNDFYVDARNYGSIARSFNHSCEPNTKVDAVTVDGIYRLKISTIKNIKKDEELTFDYDTEITDGLVGMECFCGSKNCRLIIGKKANAARKTGIVKGYSMLNEQTNNDNGEGIQSRTTGFENFSGVIIYENSNHCDREHIERKQRKHAKENTQKKTKLVRFPDFDLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XFQ0</accession>
    <name>A0A3P7XFQ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01010331">
        <property type="protein sequence ID" value="VDO57674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XFQ0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO57674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="208" mass="23469" checksum="8EB50B20DF12AC28" modified="2019-02-13" version="1">MNFNYISNYRPIAELSSVLFYENKLRCANNNVAEAILANLASDFINDGIHFTMLSYLVDTQSYKNPSFRATFNSFGEVTNTGEAEFIGGLCKLFIKLGLSVNDLGVISVYRYHAERLRRIVQAGIEVNTVDQYQGRDKPIIVLSFVWTGETENRKSELLADCRRINVAITRAKYKLILVGCQKSLSRYPTVNAVINAIPKECVAKLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XIV7</accession>
    <name>A0A3P7XIV7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000133">
        <property type="protein sequence ID" value="VDO25715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XIV7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF944">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="47"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO25715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="1021" mass="115414" checksum="50D8FEB6B7523459" modified="2019-02-13" version="1">MILCQFYNFRAIEESLKDNQNISGFSPFAQKDPENPYERRRCGLAPVGLKNIGNSCWFNVIVQTLFHIPRFRQMLFDTPIKTETKDITGKSNFWGNESGQLNEISVDVLTTSLLISLRQLAACLKASSRAYVDPTNVLKIISELNTSLNKAAPCIGIQQDATEMLLRLIEWLEVAFRIESVPEMESLHPSSSGISCGEIMDINDENMMPSGSSSEQTLTPGDEAHFGKLASDDLNSNPAPEHPFNALFHGSHVEIRPNSEITVGVSSPLKLANSLQMINLDVTYDNLYDSLEAYHLSDAPAKELWFESLPPVIIFSLVRFSYKNGQTEKVHSQFQFPRVIYMDRYLYRNRAFVSEKRIERKSLKKRLAHVKCELEGWEKFPAGDTKAPLPSLIDAVVKYASSAINGNIAVNCDTCKQQPMEVCGETLPLSVVVSDLPNPHVGSSDLKEENIMLACPCLDKTIIPPDVDINTVTNFLKTLSVNAQKRIDELQKEANTLQESIDSIFNVDGMREEPYHLHSVIVHEGEANVGHYWAYIASFPLCNTEDKEVSWRKFNDKSVEPATWQQIEEDSFGSRRACSAYCLVYTRKKCENVLYGQEQKQPAQSIIELIDSLPCDLKLEVSTDNALFDAEMIKWDADHPAIMCEPKNKSLIIPCKDMDLLDMVSYKGPVDFGALCKRHYEHAARFFGLFMLKSALNALNILDEVFLERDESAFSLIQEARLQLKIFFALLLANHVGHYEKAQKMSNVLYIDRLMYMIDWASIFGIPLSNPARSIFILRMLMNIDVTSEFRQYSKVVSTCEKVVEKFVGDDPSSLLSLNNAHVLYEVFCQMIAVLSDIVKKIDLASSQQNKTMLSMDIQQSRFLCVSIRMMERINMYATVKSSDIEQKLFFCLVHNALLIIYVIRISQRLIDNIGVESDDSILADYENFLDKEYKAMIVRLHRMGNEASERKILDAAEQKTPSSMPAPKLNIKAGNSGYDLFLLRQAVSTNLEVKCIDDLNILVRTVIQGKNSIIDNASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y4P6</accession>
    <name>A0A3P7Y4P6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011372">
        <property type="protein sequence ID" value="VDO59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y4P6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF201">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="158" mass="17537" checksum="1FAF0A159876BCAE" modified="2019-02-13" version="1">MQLYLQARLYRPLFSRLLLPVIQFALFGGAAFVAYSRVSDYKHHWSDVLVGTLFGSAIGIIVALFVAEVFSRREIPLCDAHYCKREFGLATTTERAIPLADVETGMSDVRRTYGSSSDAPIISSHNITVTGVMAPNINEVRTNQMAASSRPISRNQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YZC9</accession>
    <name>A0A3P7YZC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004409">
        <property type="protein sequence ID" value="VDO42495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="122" mass="13969" checksum="FE96EFF357ED09A7" modified="2026-01-28" version="1">MQQTDTPWNCKTGVIVHREANIKRGEREEEYNGCHHKIKLALHAYIHAKSIKRKTHIGNTMNSQLPNVPENEHFTCVPLTIKFVCAYHVCLTGTNAGNPKVLTYSLRFPLLETSNFVLNFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B9T5</accession>
    <name>A0A3P8B9T5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041243">
        <property type="protein sequence ID" value="VDP18991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B9T5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="255"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP18991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="325" mass="35268" checksum="FC06FEFEC9DD6773" modified="2019-02-13" version="1">MKYICVQDPVAFFRKVKEDTGVDFLNGLHGGTAASNLDNRNRQEEQFETYGLSPAFLRQLHITGPLTNRVFVSNLPYNVQSGRVTDYFSLAGKVTWVDLQLDKEGRSKGMAVVQFTHPIEAVQAISMLNNQRVFDRQINVKMDKFDPIDDRKEGELPVGLRGVGMGLGANGAPLGDVSSIISSLTSSTTSHNSYDSTSTAYTSQSAYQNVTGLQPSSISSVLPFSSTYTSASASLSASNSGYSTFGGVGSFNGSRSIIIKNLPLDYTWQIVRDRVQQFGPVDLTEMIAPGCAKVTFTVATDAERARKSLQNTTVEGRVIGVEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BYM5</accession>
    <name>A0A3P8BYM5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS15709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042685">
        <property type="protein sequence ID" value="VDP23370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="8">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP23370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="263" mass="28156" checksum="46C3C2AE98D72327" modified="2019-02-13" version="1">MLTPKRRVDLLRDILEAKREKRPYVIVFCGVNGVGKSTNLAKITFWLNENGHKVLIAAADTFRAGAVEQLRTHTKHLNALHANSVQLYEQGYGKDPAALAAAAISIGSFLILNXXXXGYGKDPAALAAAAISIAAERGTDVVLVDTAGRMQDNEPLMRSLAKLIQVNKPDLVLFVGEALVGNEAVDQLVKFNQALADHAALGAEGRLIDGIVLTKFDTIDDKVGAAISMTYITGQPIVFVGTGQTYKDLKSLNASAVVYSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C3F3</accession>
    <name>A0A3P8C3F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040082">
        <property type="protein sequence ID" value="VDP13134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0C8"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="159" mass="17761" checksum="C5FD2E33BA27E850" modified="2026-01-28" version="1">MSGNGSTLQKAIELVTKATEEDKKKNYPEALRLYKHGIDYFLHAIKYEAQSEKQKDTIRQRCASYLDRAEKVKEYLKSGGDRKKAVKDDASGAKGSDSDSEKDTENKKLQERLSGAIVMEKPNVSWDDIAGLEGAKEALKEAVILPIKFPQLFTGLHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F088</accession>
    <name>A0A3P8F088_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040931">
        <property type="protein sequence ID" value="VDP17479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="66" mass="7311" checksum="F325FC61FB18F6A6" modified="2026-01-28" version="1">MPNLTDSNILTQRKCESTYREISTTLCSGLCTRGESTTSPPEWGIFVATILEAIATENQKSFSHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXR0</accession>
    <name>A0A183GXR0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS20</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000005">
        <property type="protein sequence ID" value="VDO24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXR0"/>
    <dbReference type="STRING" id="387005.A0A183GXR0"/>
    <dbReference type="WBParaSite" id="OFLC_0000001901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000001901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000001901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="50"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000001901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44817" checksum="02A50DF72C764D96" modified="2016-09-07" version="1">MDVSAEEEQPGRSMPIPSRASVYAEVNQQKPREYWDYECHLIEWGNIDDYQLIRKLGRGKYSEVFEGVRSPLDEKCPVKKKKIKREIKILENLRGGTNIITLLDVVKDPISRTPALVFEYVNNTDFKQLYQTLTDYDIRYYLYELLKALDYCHSQGIMHRDVKPHNVMIDHENRTLRLIDWGLAEFYHPRQEYNVRVASRYFKGPELLVDYQCYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELFEYIDKYQIDLDPRFNDILGRHSKKRWERFVHSENQHLVSAESVDFLDKLLRYDHQERLTAKEAMQHPYFYPVVENEQRSKQDLATSVVNAGTPGNLNAPLGTPLLNNSGTVSSPPATTQSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY01</accession>
    <name>A0A183GY01_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS111</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000027">
        <property type="protein sequence ID" value="VDO24582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY01"/>
    <dbReference type="STRING" id="387005.A0A183GY01"/>
    <dbReference type="WBParaSite" id="OFLC_0000011001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000011001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000011001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000119">
        <property type="entry name" value="Putative valine--tRNA ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="15"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="572"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO24582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000011001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="857" mass="97971" checksum="2D4BB1BDF01B25C8" modified="2016-09-07" version="1">KVIIFFLFNRYRKGEVIYDQLRKIGAGVDWDRACFMMDPKITRAVTHAFIVMHEKGIIYRSNRLVNWCCILRSAISDIEVDKMELSGRTLLSVPGYLKKIEFGVLISFAYQIENSDEEVVVATTRIETMLGDSAVAVHPEDNRYKHLIGKNCIHPFLQRKLPIVADSFVDMEFGTGAVKITPAHDHNDYEVGVRHNLAFITCFTDDGNMSEQCGEFKNMKRFEARDAVLEALKKKGLFRGKSDNPMVVPLCSRSKDIVEPILKSQWYVRCNHMAQRAIEAVEKGHLKIIPDFHVATWRKWLENIRDWCISRQLWWGHRIPAYFISVDDPKIPAGTSDNNDYWVSAQNEAEAVKKAARKFDISEAKVSVKRDDDVLDTWFSSGMWPFEIFGWPEKTADLNKFFPGTLLETGHDILFFWVARMVFMSQELTGKLPFQEVYLHAMIRDAHGRKMSKSLGNVIDPLNVIHGVSLTQLNKILESGNLDPKELKTAKEGQARDYPNGIPECGTDALRFALINYTSQSRDINLDVLRIQGYRFFCNKIWQASRFTLMQLRSNFVPAEKFCLPEKISILDRWILSRLSYAVESSNNGMSSYHFSRVTTVLYNFWQYDFCDIYIEGCKPMFADGENPNGAMVARKVLFECLETGLRLLSPFMPFITEELWQRLPPRASKEQPESLCVAPYPEAEQYTFRDEALENRVAHAMHIVKTVRSLRSDYGLTAKSKTELYIIFENSSEVIEMEDLIPLITTLTSSSKVSLLTANKIQQMPSDSVQVVVSATCKISLLLKDIIDVPKEITKLTDREEKLMAQLQKLEETMSNPSYSKVPLGIRNNNAEKIASLLAESKHLNEAIIALKNSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYR2</accession>
    <name>A0A183GYR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS372</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000116">
        <property type="protein sequence ID" value="VDO25571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYR2"/>
    <dbReference type="WBParaSite" id="OFLC_0000037101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000037101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000037101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000037101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13545" checksum="0F1F52A88D230C01" modified="2016-09-07" version="1">MLMRERKLQRVLKARGNIIIIRHSHLCNGSLPVWRSSPQTYCTYAQWQEFDTPIHMPNAAELQIILKMNYSENKFYAMDRRGAFQGGFGSGSTGSFDSHGSVDRTEKWFRFESNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ48</accession>
    <name>A0A183GZ48_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi-associated PDZ and coiled-coil motif-containing protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CFTR-associated ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">PDZ protein interacting specifically with TC10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS508</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000173">
        <property type="protein sequence ID" value="VDO26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ48"/>
    <dbReference type="STRING" id="387005.A0A183GZ48"/>
    <dbReference type="WBParaSite" id="OFLC_0000050701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000050701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000050701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06800">
        <property type="entry name" value="PDZ_GOPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000067">
        <property type="entry name" value="Golgi-associated PDZ and coiled-coil motif-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038879">
        <property type="entry name" value="GOPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528:SF2">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="18">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000050701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47061" checksum="18DB3BDDCAC4D1E8" modified="2016-09-07" version="1">MTALDERPVVGPMLVWLDALEKDFDKAFVDLDLLLGEIDSDQADIMFESRQKMTALSGAFAQLVHKAQTIFQCNLRQEAELVQLREDLCLSRSAHYELERESQQLMLQVHSLHCQVHSKTAPHESDMIKKKLEQEILNFRSEIRPPAKLRSEVEFLRKENKKYRQMILAMQNEVYGARLAAKYLDKELAGRIQQIQLLGRDMRGAEHDRLWNQLEAEIHLHRHKTVIRACRGRRSSQKHLPTPPHHDYRSLRKQKGVGEIRSVKLVKASHEGLGISITGGKEHGVPILISEIHPKQPAERCGNLFVGDAILSVNGIDLRTAKHNEAVHILSEQEGELNLKVVYVAPDQDSDDDGDVMIETQGGFVFNLYEPFTDREHQMASLSTLEQTTSSCSSSASHHSDNNNLAAENGAVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0A8</accession>
    <name>A0A183H0A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS918</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000374">
        <property type="protein sequence ID" value="VDO27565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0A8"/>
    <dbReference type="WBParaSite" id="OFLC_0000091701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000091701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000091701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000091701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4511" checksum="FB7B2A37E383AFE6" modified="2016-09-07" version="1">MRRFCKMKLHLNEMNISIQSLVQPLFHLLKKASLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0J3</accession>
    <name>A0A183H0J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000419">
        <property type="protein sequence ID" value="VDO27859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0J3"/>
    <dbReference type="STRING" id="387005.A0A183H0J3"/>
    <dbReference type="WBParaSite" id="OFLC_0000100201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000100201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000100201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="645"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000100201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="788" mass="92088" checksum="6FA412AF3652203F" modified="2016-09-07" version="1">MHHSRSLPSLSSVAEEGDCILNLRSFELISEDDQKATILAHLESIMKERDRYANRLYEISSERESDENSTTTGSSSISSEVIRTAKISEIRCEDPISSPSTTERHASVELASAKAELRKLRSVIEERDEMIAELKDEAEAREVDILKMHQERLELVKDARAAKDYRDELECLQHKLANYDKLEADNGKLKEKLSELGFFKSRVTQLKEENELMQESCSVLEDQLDQCQRKISNHMDMEKKLADYQDQIKQYLVDITKDREKIEHLLVENGRLERELNNEQQKNLALERKMKCMSEDQHSSLEDFGSLGSQIADDDKKRILELELENRKLRTKLESANMFEESREIHAKLLRIEIELSKKKEECEVLDQQVQELQITLSEVTSQYQNACDLCNTLVMERDLAQQNLHEARKKFSDFQKDFQHELKNDLSKKVSELQETLKAKEGVINCLREAKVQADEELRKTVEISTSDMEELKNKLQQVEQTACNLEKQKKLLENERNTQKAINEQLEERIKENRLQVRNMENVQKKLEVCERTVMESRSRVNELESENRQLNQQLELELKKMDRLREDLVAAKSRCSDLISRLRSICVSIQLNGGKCEIQMMQSIDDDGDNDDDQKIFEIIDDVIMKALTAARREADALRLQQHAQIAELNDLKEDIERLRRSESDLNESDDRLRQLTTENRNIKEQVFLLQERIREMQQENSAKCSEVTSLKRELEELQQNSANRSKLHTELAKLQVSVRNLQLQEELLRQDNVEMQKQLKIYEEEKLATKTDFVSFEFMNLPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0L0</accession>
    <name>A0A183H0L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000431">
        <property type="protein sequence ID" value="VDO27907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0L0"/>
    <dbReference type="STRING" id="387005.A0A183H0L0"/>
    <dbReference type="WBParaSite" id="OFLC_0000101901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000101901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000101901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000101901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54599" checksum="F250366396D5C312" modified="2016-09-07" version="1">MQVNTEDVTVPWGRAPDSLDIQMGRWRMAVFQDVQESFDRSKLYFLYDPIADENSGTSGGRKGNQGLVVFDLYQRCFTREIPIFCEGTPKFIFALKCPSSSGGSSFVITCTTNRYDQTGLLLYRIELTRDGMNLESEPMALLSNFIAINDTFIVSMREDAPEVVLMTAPGLTVWRINCLSGQPSNPIESFSIPGAELNHYYDAYLSQGNIYFLSQSPDGHFDHSRIHILEIIGQHQLHTVMCNPDPVRGVPCVRKQAAIDSMSGYILLAGGEIDYGGSVSRLVDYWFLDLSTFMWQQIPAEMPIPLVEPRLTTTNSGNIYLWGDFDQPLPGMPTGTHLRILKITGFENIKPPPYDEATKKPTSPPFAPQGPYPAGTSDGSSLSYPSFGFPQTSGNTQNMAPYPQNDSPYLQNNPSYPQRQSFCPPGQTTYPQLQPQQDYRASVPYLQSDNRQFPHQGVTPQHLDGSAPGPFTSQHAYYPSQEKQNCCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0M8</accession>
    <name>A0A183H0M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1038</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000442">
        <property type="protein sequence ID" value="VDO27993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0M8"/>
    <dbReference type="STRING" id="387005.A0A183H0M8"/>
    <dbReference type="WBParaSite" id="OFLC_0000103701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000103701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000103701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO27993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000103701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55234" checksum="5F0F9C1EA0B2CC1A" modified="2016-09-07" version="1">MNGKTTHLFNRCITHFFAGLRCYQTSLLPKGAKAFINGQWNNALSDATFQVINPYNNEVICECTNCDISDAEKSVKAARKAYSEWSSSITAKERGGILENWHCKMLEKQNELAELITLEEGKPLEEARGEIAYSASFLKWFGEEARRIYGQIVNPTSMHRAHFHTREPIGIVGIITPWNFPSAMITRKAAAALAIGCTVVVKPAEDTPLSALALAQMAKEAGLPDGVFNVIPADLENTVRIAKFLCEATDVDAISFTGSTEVGKLLLSQSASTVKRVCLELGGNAPLIVFPSAHLPTAIKGTMASKFRGSGQTCISPNRFYVHSSIYNLFVEQIKHAMAELITGNGMQPNVTQGPLINERAIQKVEKLLSNAIQKGARVMLGGKRVPQSTCFEPTLLTNVTDDMDIAHTEIFGPVLAIQKFETEEEVLRLANDCRTGLAGYVFTTDYAQILRVSRNLQVGIIGVNEGIVSCAEAAFGGIKESGLGREGGSQGIDEFSQWKYVCVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0R1</accession>
    <name>A0A183H0R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1071</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000459">
        <property type="protein sequence ID" value="VDO28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0R1"/>
    <dbReference type="STRING" id="387005.A0A183H0R1"/>
    <dbReference type="WBParaSite" id="OFLC_0000107001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000107001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000107001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040271">
        <property type="entry name" value="T19C3.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443">
        <property type="entry name" value="PROTEIN CBG09852-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443:SF2">
        <property type="entry name" value="PROTEIN CBG15264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552325" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000107001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10068" checksum="2D54342241611238" modified="2016-09-07" version="1">MGIPLFLIAFIVFTFSTNDIEAQLSAMFGNAVQANNCAQWTPWGPCIWLKGSNPRWQRSYFDQLLPGKNGCREHIFFKLLNERWSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H138</accession>
    <name>A0A183H138_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1198</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000529">
        <property type="protein sequence ID" value="VDO28631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H138"/>
    <dbReference type="WBParaSite" id="OFLC_0000119701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9623" checksum="B04663807C78CCAF" modified="2016-09-07" version="1">MFDGLPNLLIKYLKSVPAAATAEPSIHAYISSNGKRSATIRLQQLQSISPSYRTGPGSNNERCSIFMRFYQPTFFFCFLFFFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1D6</accession>
    <name>A0A183H1D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000586">
        <property type="protein sequence ID" value="VDO29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1D6"/>
    <dbReference type="STRING" id="387005.A0A183H1D6"/>
    <dbReference type="WBParaSite" id="OFLC_0000129501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000129501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000129501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000129501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9213" checksum="1ED7AA9D7BF40FBC" modified="2016-09-07" version="1">MTKQITKQIERCGKSPTSCSFSYDSKKYLAKYGSFLSLVMTMSGAQNGIRDLLLKNTKSSNMLLKDISCLDLSKNYVSHSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2W4</accession>
    <name>A0A183H2W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1824</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000934">
        <property type="protein sequence ID" value="VDO30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2W4"/>
    <dbReference type="WBParaSite" id="OFLC_0000182301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000182301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000182301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000182301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9957" checksum="0A7FFA64BEE46C00" modified="2016-09-07" version="1">MDHHLNKPSYSSVHSPLYESYCYNIGERSFELLATAVNINLKHTLHSPTQFRVSPHIPAYSIDRNIHLLKIYTHPYYTCAFQYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H374</accession>
    <name>A0A183H374_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1934</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001026">
        <property type="protein sequence ID" value="VDO31300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H374"/>
    <dbReference type="STRING" id="387005.A0A183H374"/>
    <dbReference type="WBParaSite" id="OFLC_0000193301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000193301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000193301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000193301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15401" checksum="4BC999065655A022" modified="2016-09-07" version="1">MGDFDILTSDQTDMLRHFQEVTNIQDEQMALATLVSLNWDLPRAIEAQLCNDNNTGPMEVDDSFVIEHHNQATRRTVITELENQSRNNSLENDGEDPDFSFERMLAGGSLEESNSNQSPPHDNGFIFYFFLKCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3S8</accession>
    <name>A0A183H3S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2140</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001172">
        <property type="protein sequence ID" value="VDO32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3S8"/>
    <dbReference type="STRING" id="387005.A0A183H3S8"/>
    <dbReference type="WBParaSite" id="OFLC_0000213701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000213701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000213701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF38">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000213701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25704" checksum="3A5B121E149FDAD5" modified="2016-09-07" version="1">MHFCAVKDYCNTALMHDFAIVNLLQKGFNDVIKMAAEIHSLRFGALSPNFVLHKSLQKIIDLYIPEDISNAQDKLYISLTDQKRNVNRLISRFTSRDHLIDCLLASCYIPLYSGSSPPVIDGDQYIDGGFTNNLPIFEDLPTITISPFSGSAIIAPNDYSSMGSFLEWHLRVGTQELKVNVQNMVRGAQALFPPNLKILRNYYKMGQRDAMRFLLDVGILERQLGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H410</accession>
    <name>A0A183H410_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2220</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001231">
        <property type="protein sequence ID" value="VDO32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H410"/>
    <dbReference type="STRING" id="387005.A0A183H410"/>
    <dbReference type="WBParaSite" id="OFLC_0000221901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000221901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000221901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="9">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="8">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="7">
        <location>
            <begin position="192"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000221901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31705" checksum="FC079A15AD9F313E" modified="2016-09-07" version="1">MFENGIVQEESMIQDYEVTRKLWDGRIPVQFILDKLEFIQCSAKPFCIMVPGMSYFPLILPRVLQYFMAVVDHFDADSVWLRYNTKPLKWHYPVGVLFDLLKTDDLLPWTIVLKTKDSPKEVMRFRGNDLESSYIQSVKEADQLKHKARVVNSMKVDEHRQLWSSILHDKFDEFWAINKKLMEASESEPILHVPIRIYQVDCSFQQPLITPFDESDRARTVADVLKAVNIEIHSVVISHGIKIPLATPLIWMIQNLSYLDNFIHIVVLPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H415</accession>
    <name>A0A183H415_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001235">
        <property type="protein sequence ID" value="VDO32297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H415"/>
    <dbReference type="WBParaSite" id="OFLC_0000222401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000222401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000222401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000222401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20427" checksum="350D6C266BCC235E" modified="2016-09-07" version="1">MSTNRHKNFSPEAINLLANMINMTLNKAEEVLQLFFIFLSRRNQLATENSRDESSKIIDNKELPERKPVAAYGNSMDVFSEAVTSGEKGRTVYEPIKIQIPKECPSATFSYMMKAFKDNKDIYVPAKIAVTQREADIDISFHLDTQIHPEFPPLYIRIFCPNYEPKQVWINGKKCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H595</accession>
    <name>A0A183H595_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Bm1941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2655</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001569">
        <property type="protein sequence ID" value="VDO33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H595"/>
    <dbReference type="STRING" id="387005.A0A183H595"/>
    <dbReference type="WBParaSite" id="OFLC_0000265401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000265401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000265401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF11">
        <property type="entry name" value="GRUNGE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="13">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="12">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000265401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69005" checksum="7E0D3E580B38A0AE" modified="2016-09-07" version="1">MNVTSCRGKCTIRLIKDIRTLRECDVQSLADIFFSLVSFDPNNSRLASVQGEIRVGGSYQVKLPPMEKCSAVDEPDRDELLWRPGYINEESEHVYKRATRSFRMFAMVRNEQITQMERDFRTGDLCMHDAIITLHKCDYNVNYAIEAMNKNDEHMLKVTNFMNVDDAKKFARGIKTYGKNFLKIKKELLPHHRRDELVQFYYGWKKTRDATRPKPLARQRNTTTATHRKPKSNQLKASRPGSTDLADYASASETEMEELENDGRAAAYACHHCYTSKSKDWHHSGRERQLLCTECRIFYKKYGQLRPVDRPSTVPPSLYKPRSPEGNDDEEQGVRTRANKKERRGASLEVDKKGISSPNDGETAKQRNGKRKRNHAQNSEYINGSSKKRFIKGEKEDENNDMQEDEPGVSSEIHTSDVLNTGKVNEIETSPDSQSLSTSSKIISVHKEGKLMCKKKINYQGQSNILSVCAEKGSPNAELQTSASASTNVAANEQLPVSGAAENEVAEAVEIATEQPSTSFVKPVDQIFPDEMKTEEEDSDDGYWTVNDTVAETTKNALLIRVIDRRCGQMCARTDLAFRMKPGSEWDKKREARAALKNHIYNMQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N2</accession>
    <name>A0A183H5N2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2792</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001695">
        <property type="protein sequence ID" value="VDO34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N2"/>
    <dbReference type="STRING" id="387005.A0A183H5N2"/>
    <dbReference type="WBParaSite" id="OFLC_0000279101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="6">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="549"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="78175" checksum="B766AD0AD5AF7C4D" modified="2016-09-07" version="1">MLSFTVSADELKRLETAWDGRDLITEDEFFADVLCHPGIPRTTRTRIFTKFCEGSSKLSFQYFVIGIVLLTKADKDTRFEFLCNEHEVERWIEQPPQLTSRHSEIHYNFYQVLAGVTHLDEQEVEELEKVFGSINDTKLCKLTRNGFGALVGGAIANHFIDGLFRAFDENDDGLVDFKELVCGLSASCRGPHTARLNFIAQLFDSDSDGYLSKEDIHSLYMHLNLDKTVQTIHTDELGRASLTDFVCWANETKCVDDLLEIIVQLGHICLGLHPSSAEVELTVVCGFKQRVQLDAFAEWNIVSSEWWRQWVHALMSNSKVPPINNASIITVKQKNDWSYKVPSLSNEGAPLAQNLVLNKDFEALAPCLWKALLRWHGSAAREGISLQRRILPARIVDPGAANSTESVIELYPLTLLILRHGTASGSWLHSAFEWNKESSLRRLPWCVVSESRICTVEELLELLTHQLHINDVESARLWTIEIDGSPHKRLLDNDSVTLNDLKIQQSAQLLLELRNADMSWPEEVSCLENSNAEGYTADNSDLSYTLGITGLYNMGNTCYMNSALQCLSNTRPLTNYFIEGRHKIDMKGSKSKGMVATEYANVVKELWSGKKRNIAPIKLRDAIKCAGPVFAERSQHDCQEFLSILLDLLHEDLNQIENKPFIELSDSDGRPDSVVAKEVFYFISVTMFYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H669</accession>
    <name>A0A183H669_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-processing factor 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2977</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001859">
        <property type="protein sequence ID" value="VDO34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H669"/>
    <dbReference type="STRING" id="387005.A0A183H669"/>
    <dbReference type="WBParaSite" id="OFLC_0000297901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000297901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000297901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000297901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25419" checksum="C363550DB3B419BE" modified="2016-09-07" version="1">HCEEALHALRTEIIERRNKKYLLNEQEVSRRWTFEENIKRPYFHVKPLERAQLRNWRAYLDFEIECGDITRIIILFERCLIACALYEEMWIKYARYVESIGESNRARSVFRRATEVHLPRKPNVHLAYSAFEEKNGNNHSNCDICDIRTGDLFFRSFIHVVKFDDKLKCYHLSADNIDSRCSIHPSTRWQVWFLESNLKKGDDSCQVLCDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6E8</accession>
    <name>A0A183H6E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3059</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001926">
        <property type="protein sequence ID" value="VDO35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6E8"/>
    <dbReference type="STRING" id="387005.A0A183H6E8"/>
    <dbReference type="WBParaSite" id="OFLC_0000305801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000305801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000305801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000305801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9595" checksum="27A0ADF282819A00" modified="2016-09-07" version="1">MMERAFVSACALVYSKQNETVECIKNCDKALEVDPKCVKALYRKALAFQEQNDVDEAIIEYKKVLVYEPDNKIEVNEDAGSRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6J5</accession>
    <name>A0A183H6J5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3107</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01001977">
        <property type="protein sequence ID" value="VDO35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6J5"/>
    <dbReference type="STRING" id="387005.A0A183H6J5"/>
    <dbReference type="WBParaSite" id="OFLC_0000310601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000310601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000310601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="77"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000310601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37370" checksum="53BED7A9C052DDCB" modified="2016-09-07" version="1">MEVTLQLVWEFLGKNFFFNLKNFRTSPSTSRGLRRGGMMDVTPLEWDEFFDKKLNLNINNDIFCVYTKGNTGPIFYMLHGGGYSGLTWAALTEELSSQVQCRIVAPDLRGHGDTITTDELDLSTERQVEDIVAIHKNICAGEAIPTFIIGHSMGGALSVHVAASNRIENVVGIAVIDVVEGSAMEALKTMKHFLKSRPQKFGSIGGMLMQFAAVEWCCKSGTAKNSRAARVSMPAQIKKTGDLYTWRIDLSKTEPFWIGWFKGLSKLFLSCPAPKLLVLAGVDRLDTDLIVGQMQGKFQETILPKAGHAVQEDSPEDLADTLANFAIRNRFCNPLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H796</accession>
    <name>A0A183H796_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HisKA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3358</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002220">
        <property type="protein sequence ID" value="VDO36225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H796"/>
    <dbReference type="WBParaSite" id="OFLC_0000335701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000335701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000335701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000335701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8336" checksum="2ECA10FF24C1FE8E" modified="2016-09-07" version="1">MEVAYRYIEQIETTVETMRRRCLAICFTSLTIYDGIISLGQKTMRATEKLREYAEPIVYEISDSVRLKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7S5</accession>
    <name>A0A183H7S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3537</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002389">
        <property type="protein sequence ID" value="VDO36864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7S5"/>
    <dbReference type="WBParaSite" id="OFLC_0000353601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000353601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000353601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000353601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12118" checksum="91867E9B452EAC9D" modified="2016-09-07" version="1">MKPRKAKKRIKYRFYTSSRNSLCRGNLRLIKFSKRLTSSINKRICRRYQCLHASTANNSLSEYDEKSLSWKSLCSITSTFAFMALLIAFVIRIVEVFLHECSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Z2</accession>
    <name>A0A183H8Z2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3954</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002826">
        <property type="protein sequence ID" value="VDO38349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Z2"/>
    <dbReference type="STRING" id="387005.A0A183H8Z2"/>
    <dbReference type="WBParaSite" id="OFLC_0000395301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000395301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000395301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF106">
        <property type="entry name" value="CURLY SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552430" evidence="2">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000395301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29158" checksum="1087C91133D18373" modified="2016-09-07" version="1">MLLIFTLLNLLLVVNGNKKHARQRRHSSIPCGINDNKTQTQRSLSEVQRNHTDIIRLINDQNITAAIRKAKDEIDMLFNDTEIKIFRSINVSILKACRKMNLSNLFKYSIFDMFKYSDNWLIIRIQIVENDGLPSERVWNAINKISHYSKKLSYSSQISIVATEKLYNSTLTFQQIPYELSITDFGDTTITSICPVNKVTRCPLIKYRTYSGHCNNVNHPSWGASFKPMQRLLKPIYADSKFIFIMKLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9F8</accession>
    <name>A0A183H9F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003011">
        <property type="protein sequence ID" value="VDO38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9F8"/>
    <dbReference type="WBParaSite" id="OFLC_0000411901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000411901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000411901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000411901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12239" checksum="5F76596738D93FEE" modified="2016-09-07" version="1">MWNSDTMYVSKGSGIAISGVQPKRSDRNAILLVEEIVQNLEDTKAVMKSCLEMANKVLNQLGMPSLNRSAIALINVELLHEQNYNTIFCHMFNQIFLSEHLSKNALTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9T2</accession>
    <name>A0A183H9T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003143">
        <property type="protein sequence ID" value="VDO39400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9T2"/>
    <dbReference type="WBParaSite" id="OFLC_0000424301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000424301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000424301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000424301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24513" checksum="B0C19B5446F96F42" modified="2016-09-07" version="1">MAVIANVTSVDYLDDTQSSFTNPVESIIFEDNRREQQKWIFTMLYLYHRYKLNTQTIEEQKPDIAEFSIIVKSNNVISAIKIESKIMHLIFMLRIFNSKIKQNNVYIVGKPEKAIQEVTFAIQDIKMMITERGALDINAMFRGWLTAIICTLRRVYETNNLQNTVHLAVESMKLNYITGSSFVIKTNAEKDNNDEEEEGNSSSKQKTKLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA51</accession>
    <name>A0A183HA51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4363</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003276">
        <property type="protein sequence ID" value="VDO39754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA51"/>
    <dbReference type="STRING" id="387005.A0A183HA51"/>
    <dbReference type="WBParaSite" id="OFLC_0000436201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000436201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000436201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="3">
        <location>
            <begin position="2"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="230"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO39754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000436201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="59284" checksum="FA412C5E4BC96AE4" modified="2016-09-07" version="1">MNMQSEVEKLTEELESSENVVSVLHKKMAGAEAQITDLSDAIDLEKSQNEVLREKLRTQDDKLEILQENKELDEFTIQKYEKEINCLKQQLTDTKKKNDEKLLLQVEEMRKKLMKEVEAYKKELEQSEHTRARNEKAKEKLMQENEDMLNELNKLRFSVREMEKKQRKFDQTLEEEKSKVVKAGVERDRLAQEANVKELIKLKQTFLILRDNESNALMIAKETGILKSQIAELENIRNALQLDLDNAVTMKDDNGRNVLELDRMKRQLETELANAKETITELEDNLQFTEDAKLRLDVTLQAMSAELEKIRGDKERDDDERRKMMLRKLSNLESELESERRTRLTLMQQKRKLEVDLHHSLEQVEAITTQKEEFSRQLRKCNLHLKDLQLEVDETKDAKDAALLQTQDMEKRLKSLEDELARMGETNMQLIVDKRRVERERDEAVEQLNVKSNFMSTEDKKRLEAKIYELEELLEEEQNNIELGNDKLKKAQIQVFYEITQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAE9</accession>
    <name>A0A183HAE9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4461</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01003394">
        <property type="protein sequence ID" value="VDO40075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAE9"/>
    <dbReference type="STRING" id="387005.A0A183HAE9"/>
    <dbReference type="WBParaSite" id="OFLC_0000446001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000446001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000446001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000446001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34884" checksum="7D7BDA297A80B20A" modified="2016-09-07" version="1">MTEQRKQFGTRYLNDESEVFKHNAWDNVEWKLEQEEEARNRIAIQKESPVASEEAEYLLQNPAEQWDTFYRIHRGKFFMDRNWLLNEFPELNVECQESDNPLHILDVGCGVGNATIPLLQMSEQSGKMFIYACDYSQQAVNILKQNIEHWSDRCKPFVWDITGHITEVVPVESLDILLCIYVLSALPPEKQRKAVNNLVRLLKPGGILLLKDYAQFDMTQLRFKKNRLIDENFYRRGDGTLVYFFSQDELDRLFAEVGLKRETNVLDRRLIVNRAKRMKMYRMWVQCKYVKNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAJ3</accession>
    <name>A0A183HAJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4505</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003452">
        <property type="protein sequence ID" value="VDO40179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAJ3"/>
    <dbReference type="STRING" id="387005.A0A183HAJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000450401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000450401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000450401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000450401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15265" checksum="F1915149F2F31189" modified="2016-09-07" version="1">MRVTLHQNFKTISWSQTREAFSPSSYADSPRHMHEYSRCNCVCSSLWASRSVRCWMYLVKWQKGLPHAYILIWLYDKIISNEIDDVICAEIPDADVDKDLYEVKTKNMIHGPCGILNPNSLCMIDGKYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAT9</accession>
    <name>A0A183HAT9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4601</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003569">
        <property type="protein sequence ID" value="VDO40463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAT9"/>
    <dbReference type="STRING" id="387005.A0A183HAT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000460001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000460001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000460001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000460001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9181" checksum="00396B4272DFAC0F" modified="2016-09-07" version="1">MQNDEGALVELYIPRKCSSSSRIIAATDHAAVQIDLVDVDPKTGRMVPGKVIRYAICGEIRCMGESDDCILRLAKRDGLIPSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAY7</accession>
    <name>A0A183HAY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003637">
        <property type="protein sequence ID" value="VDO40624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAY7"/>
    <dbReference type="WBParaSite" id="OFLC_0000464801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000464801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000464801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000464801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11196" checksum="6D8FD4B18153B9F8" modified="2016-09-07" version="1">MPYRFAVGKNIWQKTILSAESCIQKITKVVAMSPFRPWIIHFHRNLLATLICCYLLTSHVTGVFDDSSFKAIHELEFLRSLRSALERKSNGPLKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB17</accession>
    <name>A0A183HB17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Na_H_Exchanger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS4679</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003674">
        <property type="protein sequence ID" value="VDO40706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB17"/>
    <dbReference type="STRING" id="387005.A0A183HB17"/>
    <dbReference type="WBParaSite" id="OFLC_0000467801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000467801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000467801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO40706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000467801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43676" checksum="D5EC42949B059669" modified="2016-09-07" version="1">MLYMLVFGESMLNDAVAIVLTSTSLEMSFQNITSSTSGSLFFRVISRFTYIFLISALLGAFVGFLSALLFKYVDLRKTPSLEFALLLIFAYLPYGLAEAISLSGIMAILFCSITMSQYTHFNISPITQITMQQTFRTLAFVAETCTFAYLGLALFTIKLQFQPMFVLWSIVSFVLYITEYSLHITNDLISGWLSTYLFMNEQGFSGMRGAVAFALALHISIENEETKRVLLTTTLFIVLFTIIFLGGTTLPVLHMLSNAFPDRKQRRNIGIRISSDGDKSAVLLSKTQEMFIFDQSEHLTSDTEEIGKVKMYEEDTYKGIAYKFNELFVRPLFVRRYTLQELHENRITMHRITSKILSEDCGSMIRQFSTDEISTVSSSPDQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCL8</accession>
    <name>A0A183HCL8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS5230</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01004384">
        <property type="protein sequence ID" value="VDO42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCL8"/>
    <dbReference type="STRING" id="387005.A0A183HCL8"/>
    <dbReference type="WBParaSite" id="OFLC_0000522901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000522901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000522901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000035">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF485">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE DAF-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="190"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000522901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38473" checksum="6A0F64AE53004C83" modified="2016-09-07" version="1">MRHILKKMSGGTVVFNTKQAQAADIYAFGIILYEIVFRRKSIVISNNHCDAETLDEETVSIFCESAEALIPPYPSIPGNIEVHPDLLGLMHKCWSGPVDQRPDATLARKITDATLKISGSLVDQMIRNLEQKFILQYTNNLEKLVKERTIQLEKAQEHAERLLLELLPKSVADELKVSRRVDPKNYKSATVMYSDVVGFTSLCSESLPMEVVALLSGVFQKFDIIISQHQCYKVETIGDAYMVTSGVPITSRHNHVRDIASVAIMMRDFLSEYEIPHRPGQKLHCRWGFNTGPVFAGVVGLNAPRYCVFGQTVTVAAKMENSGLPDKIQITLKSYQLLTARYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDV2</accession>
    <name>A0A183HDV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5659</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004981">
        <property type="protein sequence ID" value="VDO43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDV2"/>
    <dbReference type="STRING" id="387005.A0A183HDV2"/>
    <dbReference type="WBParaSite" id="OFLC_0000566301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000566301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000566301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000566301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38544" checksum="F0D46E744023FBC5" modified="2016-09-07" version="1">MERIVYERNHLQLGDLSESESLNDKSEELNQLRAMKAFCDNSSLSILGTLLFALNADNVVIVLAAGVLPIASIEPPLHFFGKCDPYSIVVGDMFYSAKRGQLIIVYSSMGQLNPTANNPGMNTQMIGFDIDSLGYLKNGLIWTIAHRWLKLVFYVCFVSEAFARAIIHWEDQSKEFHRKFNSFGENASNCNLGECFINMILSGQASPELVNFYRNVLKPTEWKKMIDWVNRGFGDMIGSIGRELLPGAKALQHNMKQLFIEARCALHSSRTENLLPRRLFDVDVYPYGKYADESDEEAPFKEFKSFQNLAEDIINKINEMHLVATRNRSRFSISNKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGC9</accession>
    <name>A0A183HGC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1981 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006281">
        <property type="protein sequence ID" value="VDO46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGC9"/>
    <dbReference type="STRING" id="387005.A0A183HGC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000654001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000654001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000654001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000654001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10754" checksum="7CD02FB1BFDD819F" modified="2016-09-07" version="1">MPRLIGRIIATLQHNGDRNPAFNGRIFASLKSHAGDIEKDEDKINGFIAIAHVIKDYLPSGEMPNSTEIFDIFCKILINALVITDSCLNRIGLALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGQ1</accession>
    <name>A0A183HGQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6662</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006467">
        <property type="protein sequence ID" value="VDO47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000666201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000666201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000666201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000666201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3515" checksum="1D1937197197B043" modified="2016-09-07" version="1">MSRCHHFSPGWSQYQHFSLPKLSPHEDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHP1</accession>
    <name>A0A183HHP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007024">
        <property type="protein sequence ID" value="VDO48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHP1"/>
    <dbReference type="STRING" id="387005.A0A183HHP1"/>
    <dbReference type="WBParaSite" id="OFLC_0000700201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000700201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000700201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000700201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33621" checksum="F40E14D098CC2E52" modified="2016-09-07" version="1">MEYILVDITRCTKEDMDLLKRVLHLVGEARLLFKAQNLAQGIVINTSAGNFFGNMDENDFLTLMRDIGLSVRRISGAVPNLASRLIDSSVPSANSIDTPSRPPQVFLHNQPHLYISSRRPLSTVPSQEIVKPSDVQQRRSTTHYQPSQPSAMQHRPITVNIVRVVPPRYCLSPLDSSSSMHVSHRCNSVITQRMTTPQNTKNIVCESLAKKESVLTHTGIQTRTIKQPLNTSNLPLSAKSNEPSTSRCGMLSESKMLNQSCKRIVHVIDDDDDEGGPVGLNFIADKRFFHFALILLQKLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIB0</accession>
    <name>A0A183HIB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS7223</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007399">
        <property type="protein sequence ID" value="VDO49889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIB0"/>
    <dbReference type="STRING" id="387005.A0A183HIB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000722101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000722101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000722101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF53">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO49889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000722101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16012" checksum="BED64B90804E9287" modified="2016-09-07" version="1">MDNQTIDEIDFDKIKIKYILPYSNHNNGGLMAIATFYALLFMLGTCGNAATLAVAYHVKSIDPRARRNTTLTYICALSIIDFISMLPLPMTITDQILGFWMFGTAICKLFRLLEHSGKIFSTFILVCFSIDRYCGVCHPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIM3</accession>
    <name>A0A183HIM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7335</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007581">
        <property type="protein sequence ID" value="VDO50467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000733401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000733401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000733401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000733401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10131" checksum="2F01E30AFAD1A6DB" modified="2016-09-07" version="1">MVEAFMGLLCSCCSLPFDNLANLDLFPQWKKCFHPSKNRFWGGKNKNQFKISSSKFFINLMGYSNQGKYWFYMFFCIAVQNDSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKE1</accession>
    <name>A0A183HKE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008659">
        <property type="protein sequence ID" value="VDO53351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKE1"/>
    <dbReference type="STRING" id="387005.A0A183HKE1"/>
    <dbReference type="WBParaSite" id="OFLC_0000795201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000795201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000795201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000795201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22754" checksum="1AF5536D01E1EE08" modified="2016-09-07" version="1">METMSDLPHVRNKRRTTTETLIDFGICFGNIAPAIRENYPGKKVYIVIGTSRGPSVQFHAANNRAIVIDFILDVFIFLDGTTIQVGHLRITNEFAITIQIVGNRIFAEAQVQRIEFVDVDKTFGIPEDAFATLSDLARGIVSKTINKKLADGFPIEMPQLGLPINLHNIRLQIIEHALFISTDITIPSLISNRRYAECFYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKK3</accession>
    <name>A0A183HKK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EFG_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8014</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008756">
        <property type="protein sequence ID" value="VDO53642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKK3"/>
    <dbReference type="STRING" id="387005.A0A183HKK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000801401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000801401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000801401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor EFG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000801401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6616" checksum="4832A580AD79579A" modified="2016-09-07" version="1">MFGYSTKLRTMTKGKGEYVMEFARYAPLGGDIQQQVIKQWKETQEVDEKGGDKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL12</accession>
    <name>A0A183HL12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8173</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009033">
        <property type="protein sequence ID" value="VDO54376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL12"/>
    <dbReference type="STRING" id="387005.A0A183HL12"/>
    <dbReference type="WBParaSite" id="OFLC_0000817301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000817301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000817301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000817301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="31153" checksum="DC68D58FD9B055D1" modified="2016-09-07" version="1">MGAPSSDPNVSGLITGTQLLSIDGKIEWKVGSLDWSPPASGTGDKGKKLSYIFDSLICFDSVVMSYLTTADISDKDDPSSNSGEKQHQGTSSSTNQSCNGTPTPQQSQTQAQAVPVDDGPQEFVPGKKWEWRDPNKVAEDPNATPGTCKPNPLLTTGSAAQPFYLYGSNTTNSSPQGSTATNASSTVTTTANYLNDLQTINRSPSAGYLGWNSGAANPVPFATNDMWPTVTTGSAIRQSRVASGPAGIGSFGHAAVRSGPVTNAGLPVGPYQRSNLSPFGLQQPQQQQWIFVQLHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL44</accession>
    <name>A0A183HL44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8207</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009103">
        <property type="protein sequence ID" value="VDO54567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL44"/>
    <dbReference type="STRING" id="387005.A0A183HL44"/>
    <dbReference type="WBParaSite" id="OFLC_0000820501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO54567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10440" checksum="1C971911F237825E" modified="2016-09-07" version="1">MDKFEFAIRHYAGQVWYDCGQFVEKNRLQIKWETIKLLINSQNTSIAQMFRNLTTNNLKSAQHQLSDGVIYVAQRYNQAAKALIDKMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMM8</accession>
    <name>A0A183HMM8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphatidylinositol-4,5-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="4 11">3.1.3.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS8740</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25674"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Late endosome membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 11">Lysosome membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.78" evidence="4 11"/>
    <dbReference type="EMBL" id="UZAJ01010121">
        <property type="protein sequence ID" value="VDO57155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMM8"/>
    <dbReference type="STRING" id="387005.A0A183HMM8"/>
    <dbReference type="WBParaSite" id="OFLC_0000873901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000873901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000873901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034597">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019178">
        <property type="entry name" value="PtdIns-P2-Ptase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21014">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21014:SF6">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09788">
        <property type="entry name" value="Tmemb_55A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO57155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000873901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25624" checksum="C26F2AC66A130DC7" modified="2016-09-07" version="1">MDNVNEYENSEQQPLLSSERSASTPNYEGTETQAPVTPEEYISHEEEQHTVPQIQQAISGESSGTVRQAGPIVTCRVCSATFVIENKTSQHVVKCNQCNEATPIRPAPPGKKYVRCPCNCLLLCKASSNRIACPRVNCKRVITLGGSAPVGTAVRAPTGTCRVLCAHCQEMFMFNTLNLTVAKCPHCQKISSVGREYARNRAIFFIACSFLFSAGAVGLMVSFLVISRNSLFLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMU9</accession>
    <name>A0A183HMU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010269">
        <property type="protein sequence ID" value="VDO57502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMU9"/>
    <dbReference type="WBParaSite" id="OFLC_0000881001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000881001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000881001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000881001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8876" checksum="388680440F0834CC" modified="2016-09-07" version="1">MSKKVKNIENVKMMSMKSKLPTNMIRMKLQKQIQEVNVTDGKAIIRITRKKQSDERKVGAWRKIEDAVLVMKNSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN95</accession>
    <name>A0A183HN95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010546">
        <property type="protein sequence ID" value="VDO58162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN95"/>
    <dbReference type="STRING" id="387005.A0A183HN95"/>
    <dbReference type="WBParaSite" id="OFLC_0000895601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000895601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000895601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000895601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19225" checksum="F4C14D0E9AD150D0" modified="2016-09-07" version="1">MYPCYSSKFCFQIILYVVFIIKNTIAVGGILGLKTLTGDMPYLGSGNSWINYPRIALGGASLYSSHPLWGHDHSILEGYYNPYHVFNVYGNRGDTYGGHGNAGSIFGGYSNADSRFLGYGNMGGIFNGYDNVGVVTSKYDNAGIYSPYQLLTTTKSPNSKSNLYYKGRGNPWLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNM7</accession>
    <name>A0A183HNM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9086</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010788">
        <property type="protein sequence ID" value="VDO58649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNM7"/>
    <dbReference type="STRING" id="387005.A0A183HNM7"/>
    <dbReference type="WBParaSite" id="OFLC_0000908801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000908801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000908801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF54">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO58649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000908801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13553" checksum="C7CC7423B9E16458" modified="2016-09-07" version="1">MQEVAIIQNSLDKFKFMLRSKSIRLMYEREGKPRNENLQNFSTKNTSIMDFFSKRLKDGISSSRNKAKYQFGDYHSYDTIISWLDDIESFYPDMAKVFTIGQTFEGRKIKGIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPG0</accession>
    <name>A0A183HPG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ala_racemase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9374</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011422">
        <property type="protein sequence ID" value="VDO60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPG0"/>
    <dbReference type="STRING" id="387005.A0A183HPG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000937101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000937101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000937101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000937101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14996" checksum="40342A92E456C791" modified="2016-09-07" version="1">MRILNAKRPARVRIMSELEPFLPLLPDVADMGIKEQKQLFQQLYSAGIAASASLHKWLTMSAAQQFPRFCAKFGATACVGEMKEDLCIDSAQVEKAYDIASAIQNTQLSPSQQIPFTSEDAEVFIKISFQLISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ18</accession>
    <name>A0A183HQ18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9581</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011902">
        <property type="protein sequence ID" value="VDO61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ18"/>
    <dbReference type="WBParaSite" id="OFLC_0000957901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000957901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000957901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000957901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13897" checksum="E1598EDC4B8337E5" modified="2016-09-07" version="1">MMNEENGLQNLNENIPSKESCSEFSVPGTSTTSLLPLRRKRKHGRSSDYKTQKDVDSKTQDREDSCFSRMDEFDHFGLSIADYIRGIAKLDEKAAVWIRGEIWTLLTKCRMKALEGCSGNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRB6</accession>
    <name>A0A183HRB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10031</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012945">
        <property type="protein sequence ID" value="VDO65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRB6"/>
    <dbReference type="STRING" id="387005.A0A183HRB6"/>
    <dbReference type="WBParaSite" id="OFLC_0001002701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001002701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001002701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001002701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14588" checksum="FFBC462A062EA013" modified="2016-09-07" version="1">MEFKAAFHVDDTGEKIGTLIISSTIDGKVKILQKGINITVEIESLKFVDKEQAFGLPQDALDNLATLAKDVISQLANNYVLDGFDVKLEDTTLSFLLINSKFAIIDHAFHISTDFAIPPSLLGNASSTICRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRC1</accession>
    <name>A0A183HRC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10033</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012946">
        <property type="protein sequence ID" value="VDO65293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRC1"/>
    <dbReference type="STRING" id="387005.A0A183HRC1"/>
    <dbReference type="WBParaSite" id="OFLC_0001003201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001003201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001003201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001003201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17312" checksum="31E7B6ED8C3ECFD2" modified="2016-09-07" version="1">MTTAFYLGRSRLPIRHFYAAITSATATTVRSSNFQSQHWVIGIRHASTAKDIFVASKDALVDIPDIPIIAMPPEAGTSSGFSFYEKWLLKLDMLDIFGLNGSTVDSLGLFSWYSPASWYRIGLEFIHNHFDLPWFASIICSKHFHVYIRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS97</accession>
    <name>A0A183HS97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10360</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013739">
        <property type="protein sequence ID" value="VDO67898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS97"/>
    <dbReference type="WBParaSite" id="OFLC_0001035801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001035801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001035801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO67898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001035801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10978" checksum="51CE77E259249BF1" modified="2016-09-07" version="1">MFDTTITTSTLIIAGCINFATLLKIKNYSKSREVKQLMINSSTKRKHDIFFFKQSCIGGVTMIVSALVFNIGQQVLTNKWALFAVTTISWEMAHVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSM0</accession>
    <name>A0A183HSM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10477</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013997">
        <property type="protein sequence ID" value="VDO68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSM0"/>
    <dbReference type="STRING" id="387005.A0A183HSM0"/>
    <dbReference type="WBParaSite" id="OFLC_0001048101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001048101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001048101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="1">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001048101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17917" checksum="76884B465AEC3C10" modified="2016-09-07" version="1">FVSTTEHFDKCSIGCGPDGEEPFCGQTAALYVFSEAVNAQQANAIFCLGPSYQSRFLHEAETGLSDDYKKFLFDGKLSAAIVIAYSPKNCDGQLCLHLASKTSAPYFVQIPHAIMKQGVEVVKTYSIHNSLHSLGGIQMLLPLFSQLDFPQYDENVRKIDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU02</accession>
    <name>A0A183HU02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10969</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015253">
        <property type="protein sequence ID" value="VDO72773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU02"/>
    <dbReference type="STRING" id="387005.A0A183HU02"/>
    <dbReference type="WBParaSite" id="OFLC_0001096401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001096401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001096401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001096401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11000" checksum="F0E44A8F9919B523" modified="2016-09-07" version="1">MIAMTTGISLHVQPQDIALTIGEDKSVQFYTTDDLPSAVDIILMRSDSFDGTPHIFQLDNQTRSAKVVVTGLQITSYSILEIEGCNSTNPIGKCPFEYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU16</accession>
    <name>A0A183HU16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10982</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015289">
        <property type="protein sequence ID" value="VDO72864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU16"/>
    <dbReference type="WBParaSite" id="OFLC_0001097801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001097801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001097801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001097801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9586" checksum="BB9B12C76CF77F8D" modified="2016-09-07" version="1">MDELDGSQSLHRLLRQEAATLALNRFETLHLATNLASSFLLLLLLLQINPLLPLNFKDNGCLFDGKAFTKLLLLLLSSKLYINFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU28</accession>
    <name>A0A183HU28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015305">
        <property type="protein sequence ID" value="VDO72949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU28"/>
    <dbReference type="STRING" id="387005.A0A183HU28"/>
    <dbReference type="WBParaSite" id="OFLC_0001099001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001099001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001099001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001099001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25163" checksum="75C84987B87CF031" modified="2016-09-07" version="1">MNRIYKILRCVVCLKLMTQKRPFEPIQAAELRCAVFLAIESNENNELKVDESKLKRKPGYSMIYHFLRQNRFLATAAVFEKEMHQKIIPLEELKKENATTFCFQFVGDNITLSDSIPTETEQEMKESHSTIIRSSETNDNDSKFMSYLGKNNNNKESNAKTIERQQISHSESNTTLKSASSESEISRDGNETSNRYFHLPNFKEKFSISVILLFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU44</accession>
    <name>A0A183HU44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FerB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015340">
        <property type="protein sequence ID" value="VDO73052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU44"/>
    <dbReference type="STRING" id="387005.A0A183HU44"/>
    <dbReference type="WBParaSite" id="OFLC_0001100601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001100601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001100601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferlin B-domain" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001100601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20550" checksum="D2A8B551368B56E3" modified="2016-09-07" version="1">MYCGRLRAITLKWPSYDDKREKREQIPAVVHLRLWFGKVTDRGNWDKAIKPGVVQYFAEVFENQRRHLVNQWIETSGRNGEPYARSDETGIIRMSEDDVKVSHGWSYKGPWKIMFCHDMWVGPDAGHSQYEDEIFEIQQKQDDIWTDLYYTSGSGNLIDNARDRDAPPGDKSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU89</accession>
    <name>A0A183HU89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11048</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015446">
        <property type="protein sequence ID" value="VDO73419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU89"/>
    <dbReference type="WBParaSite" id="OFLC_0001105101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001105101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001105101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001105101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13834" checksum="CDCE716A83A8B2A7" modified="2016-09-07" version="1">MERSLSAQNGLNAFVEPLGMAEIANDLLVGEWLRKSMKEDGVMQVINVVVPMNMKVIIVTKLSSVEMMVNLSMEGLFQGIPDRIPQMYSLQLKDECSTIRPILLIYHFSTSSRICSCHMQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUU3</accession>
    <name>A0A183HUU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11259</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016051">
        <property type="protein sequence ID" value="VDO75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUU3"/>
    <dbReference type="STRING" id="387005.A0A183HUU3"/>
    <dbReference type="WBParaSite" id="OFLC_0001125501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001125501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001125501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001125501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17918" checksum="B0D6CE6F6FE09AB4" modified="2016-09-07" version="1">MSLEKHSHQYFKRFHYERMDELRMFLENEVFALCPVPLQFTLFDLQEFSFLKESREHRGRLDSSIHSETDLNPTESVDFQILQPTDLNPFIVGITDMDSCAKDINVTVLGNMKSSLNDDVESERYSMDDNFSQLAPVLCNTSLNLLRFIGLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV35</accession>
    <name>A0A183HV35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BBS2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016295">
        <property type="protein sequence ID" value="VDO75805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV35"/>
    <dbReference type="STRING" id="387005.A0A183HV35"/>
    <dbReference type="WBParaSite" id="OFLC_0001134701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001134701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001134701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001134701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12738" checksum="9B2BA3C4354DFC95" modified="2016-09-07" version="1">MLEKNQTCTQDKRAELQNYEQCKNDATSEDENEEIEQIIPVRFTFHANTTLECSLIINHQSKEPSVELQLTVSSNAIFRAVILFAEGCLTHKTSGYTIYDPYIPCLHGLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVD6</accession>
    <name>A0A183HVD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016530">
        <property type="protein sequence ID" value="VDO76528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVD6"/>
    <dbReference type="STRING" id="387005.A0A183HVD6"/>
    <dbReference type="WBParaSite" id="OFLC_0001144801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001144801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001144801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001144801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15862" checksum="77405751299555B2" modified="2016-09-07" version="1">MFTQNEEEWRETNELGSSEYRRRMTHEDICHCDDERQFALQSASHDWQKSTDYCGGFSDYMTLYPVKLWIRNDLKRRNQQRRCHSLRRCYRSSQRYRDYNYSEAIENCQKHLDSTDHTGQFVEGSENLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVG7</accession>
    <name>A0A183HVG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016610">
        <property type="protein sequence ID" value="VDO76776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVG7"/>
    <dbReference type="STRING" id="387005.A0A183HVG7"/>
    <dbReference type="WBParaSite" id="OFLC_0001147901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001147901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001147901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001147901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16969" checksum="B14C23B86CCF89CA" modified="2016-09-07" version="1">MQSETKTEASESEIKAKKAAIAAKKRKQAMDQMNRLQKQFVTQNQDLLGKEFLEGKGPHRQDDDEEPLGILPQDSGFPVCLGIDRSTAKCDCCRRITCILCQEDEDVTASGQALVCAAFMQKYVYRILQFFFFDSCLLSKKRKKLDSNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWA1</accession>
    <name>A0A183HWA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11763</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017443">
        <property type="protein sequence ID" value="VDO79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWA1"/>
    <dbReference type="STRING" id="387005.A0A183HWA1"/>
    <dbReference type="WBParaSite" id="OFLC_0001176301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001176301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001176301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001176301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10090" checksum="2CAF35ADB7E27CA8" modified="2016-09-07" version="1">MTHFACLCTRYMCSGVPAVLSTLLANINAFYAHTTATSAVSASDRFNASNFGRDRFVKLLDQLHNSLRIDLSMYRVNYFIFFPFIIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWK7</accession>
    <name>A0A183HWK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017712">
        <property type="protein sequence ID" value="VDO79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWK7"/>
    <dbReference type="STRING" id="387005.A0A183HWK7"/>
    <dbReference type="WBParaSite" id="OFLC_0001186901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001186901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001186901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001186901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14228" checksum="6AC0ABD20C07BB45" modified="2016-09-07" version="1">MQLFYVLKTGHDSELKEYNNLKQCTKVAVEEMKEEPSTVAKKIKHRSRNSVMSPNPSVDLPPEWYVECVDVLQEVMSERTSTHFISSGNEVSILNFTKYTKLRIISLLNISQSFGIYRAFLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXE7</accession>
    <name>A0A183HXE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ecdysone-induced protein 74EF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12165</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018529">
        <property type="protein sequence ID" value="VDO82435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXE7"/>
    <dbReference type="STRING" id="387005.A0A183HXE7"/>
    <dbReference type="WBParaSite" id="OFLC_0001215901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001215901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001215901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001215901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19382" checksum="1A58F127DDABA2F1" modified="2016-09-07" version="1">MKYKSDEKKFSVIHSTQQNGNGLILGVRPDLATHMLVPQELLQQNHLGNRILQHVLPSPQSDFIGSGGGYPPQSTPSALPQVSPPTVNMRPVNSGYLIQNNDYQMDPYSNVISSAASDGDGSSSQGDGQVSRKRLRSEQQPPPPPSQQQQHQQTQSHNSVSNNVKSEPQKVGYYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXL2</accession>
    <name>A0A183HXL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12225</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018720">
        <property type="protein sequence ID" value="VDO82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXL2"/>
    <dbReference type="STRING" id="387005.A0A183HXL2"/>
    <dbReference type="WBParaSite" id="OFLC_0001222501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001222501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001222501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001222501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8027" checksum="0BE102A8E030DB96" modified="2016-09-07" version="1">MINHAQFKTDVLSPLMIDNLLNLEVQHLSGGELQRVALALCLGKVADVYLIDEPSAYLDSEQRLHAAKVIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY76</accession>
    <name>A0A183HY76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039843">
        <property type="protein sequence ID" value="VDP11315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY76"/>
    <dbReference type="STRING" id="387005.A0A183HY76"/>
    <dbReference type="WBParaSite" id="OFLC_0001243901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001243901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001243901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001243901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14939" checksum="DD8BB93E640F8687" modified="2016-09-07" version="1">MIIFVTKAVKKSTLSNSIKKQKLEQAYPPQFFLISYLLDWIINNAESNLSTACVGALAYTSPEEFTHNYKAYSHLLKLTARCINILFTLELDKLIPLTRRFEKRLKHMKGSEGDYADGARINSQSILTVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYE0</accession>
    <name>A0A183HYE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12502</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039856">
        <property type="protein sequence ID" value="VDP11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYE0"/>
    <dbReference type="STRING" id="387005.A0A183HYE0"/>
    <dbReference type="WBParaSite" id="OFLC_0001250301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001250301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001250301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF219">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001250301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="48771" checksum="9261579F3D1F5C6E" modified="2016-09-07" version="1">MMNPTWLKFILLIVMFSITFGAGMIPVKVLKILRKHAASASTSAKQRNVSLVLCLLTCFSGGVFFATCFLHLFPELTEHLHEMKAEYGFSVSYPLAELLSCIGFFLLFFVEEVILLLLPATGHLHGPTAVQITEGFYERNHDAEHCCHESINIDAPLKTCLSCGPKDGDSSKKGLLCTTNSLHRASASGQRINKGPGYGHPADGKDSTPLLQKYAYNGEYGSVSRKSRGQESPGKRKALTLAEPEACERNCDNVKEDPPILMKSRPHAHSHGVRSITFVLAISFHSIIEGLAFGVQTDNTRIVTLFISLMVHKVIVAFSVGLQLGRTHAHDLGWVCLSMGLFSIMSPFGGFIGTFVQSSQMDTQVKDLTVLIFQGVAVGTFIYVLLHERDNEHPNLLKLIFMLIGFALIGGLRFFDSHSHEHSHGSLHNHGTFVITSSPTTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ2</accession>
    <name>A0A183HYQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12614</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039883">
        <property type="protein sequence ID" value="VDP11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0001261501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8216" checksum="250C8624C3448819" modified="2016-09-07" version="1">MDHCHNLTDFITGLKYFTIIFCSPTMGKVDFYYVFEDQREINPIPILLSVLLELAENKKTPYYQLNRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYU8</accession>
    <name>A0A183HYU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12660</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039897">
        <property type="protein sequence ID" value="VDP11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYU8"/>
    <dbReference type="STRING" id="387005.A0A183HYU8"/>
    <dbReference type="WBParaSite" id="OFLC_0001266101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001266101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001266101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001266101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="31947" checksum="879D222850F40F82" modified="2016-09-07" version="1">MNRASSWKFVRKGLPFLAVGGATLLLAYKIQQIKFEFGPSSCTLADAEEISQFLDTKGIRHQQESIEAVYQELIEKEDDNWENIRGPRDSEDNKEFLQLNIPATDHRIDSSGDFSEAPPPPPGFPNTSREAVRGSERTPVISSPSGSDFLHASTNERGNIQIIADPTIDRQTSFPSSSAPTSQSQLTQPVLDPASSSISAIETAVPTQPFYVPAVPDFNQETLYTTAESSQSVTSNPLDPDISLAQTLIAGASCSHPADPENKEHLVDPALLAEILQLGFEEAIAVLAISKTKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ04</accession>
    <name>A0A183HZ04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12716</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039913">
        <property type="protein sequence ID" value="VDP11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ04"/>
    <dbReference type="STRING" id="387005.A0A183HZ04"/>
    <dbReference type="WBParaSite" id="OFLC_0001271701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001271701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001271701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF114">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552694" evidence="5">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001271701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16698" checksum="6CBA222B109CE287" modified="2016-09-07" version="1">MTIYRGVLGGIIALLVCVSHSAIIPQQHTGIQSYSVTGRLFCGTQPAPGVRVKLVDDDFGSDPDDDLDAGYTDQHGYFKLSGDTNEMTTIDPHLKIYHDCNDGVTPCQRRWKFELPNHYITNGKVPQKILDIGTWNLEAIMPDESHDCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH3</accession>
    <name>A0A183HZH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12885</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039964">
        <property type="protein sequence ID" value="VDP12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH3"/>
    <dbReference type="STRING" id="387005.A0A183HZH3"/>
    <dbReference type="WBParaSite" id="OFLC_0001288601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF310">
        <property type="entry name" value="PROTEIN 60A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552693" evidence="9">
        <location>
            <begin position="25"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="276"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42651" checksum="01D0CB81DE3FF7EE" modified="2016-09-07" version="1">MGCDNRSLLSVLLIPVYCFSVVQGSTGFYVDNENAQSIPLAVSRHGSARLESKILELLGIEYPRPLVVGVKDDIASRFMADLYRNLEHDVELNPAYKYLASGQLLSADEKEAIELGEADTIVSFLPREQRIVPNYGTSLQFDLANIPIGGQLVHAELRIFFNGSMKPQRVFATVPYSRDLSATIIESRISSSGHFIINITETLLCWIHNRSILSIVTLYAISAHGERKLLENFGEWRGFGIASFVDGVNHIHQRIKRDVPDETNEFDDYGYGFSARPDPLLILILDLFSASNKGCRRRTLYVDFKDLGWQDWVIAPDGYHAYYCDGFCSFPLNNHMNATNHAIVQTLVHLIDPTRCVHKFMLEASTNLVFTSRFLMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZY3</accession>
    <name>A0A183HZY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipase, patatin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13045</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040023">
        <property type="protein sequence ID" value="VDP12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZY3"/>
    <dbReference type="STRING" id="387005.A0A183HZY3"/>
    <dbReference type="WBParaSite" id="OFLC_0001304601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001304601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001304601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07211">
        <property type="entry name" value="Pat_PNPLA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045217">
        <property type="entry name" value="PNPLA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="193"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="197"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="375"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001304601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58811" checksum="4164F5E3BEDD214F" modified="2016-09-07" version="1">MWEKASTSFWRFGKRFKNSGKRIKRKNHENEGSIGTTNHTENKSVKNAVFRSQPFTSSLPSATHRSYLSSILSLLWPSDGTKEIEKIDIKTQRIKAVSVPKLALFDRTKSLVSSLLSAETDGSVMLRTRELCKHYMEYPEARAAGFKFHDSVIKKLKLLLRRTNDEMLKEHIRQFLILMGDVSIPRGTGIRVLSLDGGGTRGVLGLDILQALENNLKGPKVVEVFDLIVGVSTGAIIGALLTAKRLSIEKCKEIYIEISRELFSQGKFSGMSGLLLSHAYYNTEKWKQILRNVIGEDTLLEICGRWGTPMLSIVSCTVNTPTLQPYIFRTYGHPRGSESHYRGGCNHKAWEALQASAAAPGYFQEVSLGPLLYQDGGVLTNNPTALAIHEAHMLWPHERIQCVVSVGNGRTVSEVELNGVKLSTRLQEKILRIIDSATDTELVDLCMRDTLSKGSYMRFNPYTSYPYPLDEIDPKKLEQMSQDAQLYISRNQTKFEATAKILLAKPSLKQRFVRNWNQLIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0A8</accession>
    <name>A0A183I0A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13170</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040071">
        <property type="protein sequence ID" value="VDP13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0A8"/>
    <dbReference type="STRING" id="387005.A0A183I0A8"/>
    <dbReference type="WBParaSite" id="OFLC_0001317101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001317101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001317101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="427"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001317101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62943" checksum="BD19E3DCB3EA1F91" modified="2016-09-07" version="1">MVTQSCDITVIDLEYGEVEFPQGTAVKWENGYLLLIGKAYFRSEINIIVYFDEYRNAKWQFLSIWKFQACLPSNTMCYDECKILAEKLSACKLIKEIIDILDDLIGGWAVIYYREDLKKVLVGRDVFGRKSLLWKRMTKKFYFSVFACDRQVIRMFVPRQANVFYFSKLFQNIFQCSSWYDVPPGTVTVLDLCSEENITVFHVFEVNGPWIEQFSKLNRVHRKAVSERFMLSYELSLKNVNREDIAIIMLKRLEEAVYRTVFNFDNSTKCISLLFSGGVDSLLIAHLMARCMPQNVLFDLVNVAFDKGKNYDEAPDRPQSKKAFKYLKSCYPELSLRLLLVNVDLNELVNCRKKYISSAIAPACCVLDDSIGCVQWFAARGEGFLFEDEEKPFVSGKSEARTVVVGSGADELFGGYMRHRTTYLKRGRNALVEELREELRRIGERNLGRDDRVVSSLGKDLKSPFLDDLFVEWVTSLPLEYKTDFTQPRGIGEKWLIREALKLLATPQMLCCTPKRAMQFGTRIAKLENREEKGNDFCPRLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0K2</accession>
    <name>A0A183I0K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Filamin/ABP280 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13264</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040116">
        <property type="protein sequence ID" value="VDP13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0K2"/>
    <dbReference type="STRING" id="387005.A0A183I0K2"/>
    <dbReference type="WBParaSite" id="OFLC_0001326501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001326501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001326501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF13">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="213"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="305"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="396"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="488"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="626"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="722"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001326501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="938" mass="103309" checksum="D4D599681EF05234" modified="2016-09-07" version="1">MPEMNYCRFHDTGRYSVDVFINGVPYGERQYVRVIQSGRGAVLVDEIEQALVGWSSKLILRAESDAGKHLSIAIIDSERNPVPVLLKKLPDEIFEVEFTPRTEGVHSVSVLVGDEHVRGSPFKISVLDLSAVRVIGLKNDRVGIEQRFNVDWSSSGGSNATIQVTCGGEEIPCTMKRVKKGLHVCSFIPRQVGLHLIDVRIDEMLLPECPYECIVSDAGSVRARGDALARAQRGKTARFEVSLNDIEHGELDVVVSDSRGRPLPVRCYKQHDDSYWVEFTPENIGLHHIEITFADAPIVGSPFRCIVIDPRKVFIKGINEPFILNHPAVITVNRQLAGDGDLTVELIDPSNELVRLDMQTTADGDDVFEFIPTKIGQYKLSTKLAGFFVDGTPHTLIVEEHGKPAVRGVAIEHPVEVERPTNIIFDAKNVKGNLKIDVRGPKKAKVRHTANKNPDGTTEISFTPTEVGRYLVNIEHNNRIISGSPFGIEVVDPRKVIVNDHMADENGVYQFAVQQRNIIDVDATAAGSGKLRAEVRDWDGKLVNDCDIESLGYGKYRIIYCPHQPGKYSIYLYWSDMAVQKAQPLHVIAEGEQPSTSRALSFTNTVMATSHNTSRSRSEDYPSHERNETDFSRVVVRGEGLTRAANNEPTEFIIDGSDVSRDGQISCSLFGQKADIPVRLNHLGNNVYKAVYTPLIPGIYELQVLWDGHHVRGSPFRVQVDLHSSAAEAISIDANTLKMGIVNEDVKTIIDTRKAGPGQLSAQCMGPTKLAYCELYDLRDGTYTLSIRPSEIGKHTLDEQVPGSPFIFNVSYPPDASKVEVKWHGEHVPGSPFLVMIVDTEQELQRFLCGDAPSPQPATPFIPPGWIGTPPPPPLFLGGPPPHGPPPFLQPHAGALPLPSPGVPGTGTHGSMLPYGAMPPQPPHAMRTAIRPRFMSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0R6</accession>
    <name>A0A183I0R6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-1,4-mannosyltransferase bre-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Bacillus thuringiensis toxin-resistant protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13328</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040146">
        <property type="protein sequence ID" value="VDP13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0R6"/>
    <dbReference type="STRING" id="387005.A0A183I0R6"/>
    <dbReference type="WBParaSite" id="OFLC_0001332901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001332901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001332901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000175">
        <property type="entry name" value="Beta-1,4-mannosyltransferase bre-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0978">Insecticide resistance</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="190"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00084120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001332901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53407" checksum="B2A6A0AF98F671CC" modified="2016-09-07" version="1">MNINAETKHAIHVASFFCWLILFEVICGTIPLFSQTQSRYVSTSSLIDRYGYFGTFILYVIRVASLLVLPQCIFNMLGLVLFNGFREKVRLKAAPLLAPLVCFRVVTRGDYPELVKQNVNYNMTKCREVGMENFFFEVVTDKAICLPSKPRLREVIVPSAYRTKSGAQFKSRALQYCLEDGINILQDDDWIVHLDEETLLTNNSICGILNFCEDGKHQFGQGIITYANGDIVNWITTLSDSFRVADDMGKLRFQFRFFHKPLFGWKGSFVVTQVGAERNVSFDHGREGSIAEDCFFSMIAFRDGYTFDFIEGEMLEKSPFTFWDFLQQRKRWLQGIFLTVHAKQIPTKNKILLGLSFYAWASMPVTTLQMYLFHAFPLPPCFIFDFLVAFVAAVNLYMYIYGVLKSFSHKYRHSPVRLCLYMIGALLTIPFNICIENIAVIWGMLGNKNGFYVVKKDERMISIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3T0</accession>
    <name>A0A183I3T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Filamin/ABP280 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14392</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040819">
        <property type="protein sequence ID" value="VDP16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3T0"/>
    <dbReference type="STRING" id="387005.A0A183I3T0"/>
    <dbReference type="WBParaSite" id="OFLC_0001440001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001440001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001440001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="229"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="335"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="419"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="523"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001440001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="67315" checksum="83192EF20BDC0682" modified="2016-09-07" version="1">MGISFSPREIGEHLITIKENERIIQESNFQVEVIRNQTGDASKVVVSGTGKTNAICQQDNNVIIDMHDSGCGNLSISIQGPSEAELKCIENKGNLANVVYRPTEPGIYILSVKFAGVHVKDSPFTINCAGKGMGKVKESISKEVKQAPAILPEQDTALYLHLENVSPLDINARIIHPNGYSEDAVVRDLGDNLYRIEFRPAMDGPHAVSIFYKGQHILGSPFQFTVGQITEVGSYKVRAAGFELKRAEANRKQSFNLYTREAGQGELEVTVEGPSKAELQFYEHEDGNCHFDYKIPKAGEYLISIKFNAEHIPDSPFKVFVASVAEEVLHLELISLSNSGTPGEECSFMINKHGAIGNLEAKVHTPANEIEAINIVPIDENDSYCIRFIPLETGDYYVDVTLDGIPIHESPFRFRIGTSQGSDPSIITVIGDGIHSGQTGQTSEFVINTYDAGMGFLQIRIDGPSKVTLNACEVCFESIHIPGSPFKVVMEGKKLGGGEPDTSFIKIDAIAKINKKIAEQIPIFSGDANKVMVKGSGLNKFFPGQSATFNINTGLAGDNVLFVGLLTSKGPCEEITLQHLGNGQYVVKYLVQEEVKGFIFIKYGDMNVPGSPFAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I453</accession>
    <name>A0A183I453_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040917">
        <property type="protein sequence ID" value="VDP17391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I453"/>
    <dbReference type="STRING" id="387005.A0A183I453"/>
    <dbReference type="WBParaSite" id="OFLC_0001452301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001452301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001452301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001452301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22754" checksum="6E50A3346F758967" modified="2016-09-07" version="1">MPPFNFIFHKLSFPKQISNDALNYICSIKGIPKRYFILKIRPKHQSYWESHIYHYVEEELRLISGIVQIYHCLSFIDKCLTVQEFTAGTLKELIKIQNIGDKKLNELIIALIVLDLMKILRCIHQMNIIHGCFKSDNVFITKRITSRPQLDTLGNGATLLVKLANWDYAIRNTDGTKYGGQYINENKVVTNDDYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4E5</accession>
    <name>A0A183I4E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14606</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040996">
        <property type="protein sequence ID" value="VDP17834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4E5"/>
    <dbReference type="STRING" id="387005.A0A183I4E5"/>
    <dbReference type="WBParaSite" id="OFLC_0001461501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001461501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001461501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001461501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28773" checksum="4BA4F339724C5B60" modified="2016-09-07" version="1">MSTSLPTSNTVIGSHDHFHLSTNERRIRNRSLCSLLLTPPLYPGYSAKLDKSLKSNFYRSSWKSTVSEIATPSNPISSNSISVDCYPSSTQSVTGTTNTFQREISFQLQSTENSPKKYTNSKESSGYSSGTSESDLENEQHSKKTLATTNTDSSNNTTMNDNYNNNISGEQEVGKVERATKRPPTRQQRNRQHTLEKNRRRSVPASLRDAFTDEIVRVLEINGVFQYETDAVSFHFDYYYHHHQISLLIIEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Q2</accession>
    <name>A0A183I4Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14714</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041117">
        <property type="protein sequence ID" value="VDP18379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Q2"/>
    <dbReference type="WBParaSite" id="OFLC_0001472501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001472501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001472501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001472501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5086" checksum="BC75F7893B201EDD" modified="2016-09-07" version="1">MKKKEGSSGSIDSKRRSEETVEEVAIRGRGRGGGKVKPSFCVSDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4S0</accession>
    <name>A0A183I4S0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osteopontin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041135">
        <property type="protein sequence ID" value="VDP18455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4S0"/>
    <dbReference type="STRING" id="387005.A0A183I4S0"/>
    <dbReference type="WBParaSite" id="OFLC_0001474301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001474301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001474301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001474301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5608" checksum="D82D10CFED9608F4" modified="2016-09-07" version="1">SSPEVKHPDDNDEDDDAIIIRVTKPSSTNSNVQSNNEATPLLDNQKSETKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4U7</accession>
    <name>A0A183I4U7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED18</name>
        <name evidence="11" type="ORF">OFLC_LOCUS14759</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041166">
        <property type="protein sequence ID" value="VDP18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4U7"/>
    <dbReference type="STRING" id="387005.A0A183I4U7"/>
    <dbReference type="WBParaSite" id="OFLC_0001477001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001477001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001477001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.320.10:FF:000013">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001477001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25816" checksum="C79E13C0671FD814" modified="2016-09-07" version="1">MERFAERSREAIATVPVVSSTSPSSSNYQCKNDLLKECILYGSVLKEHEEKLLQRLRGLCDPGQHSFNEHEMDPDVTVRLRRKFGGPDANSFQWHFRYMGAAEPDVHCPTIIRKSIDSLIYSSNMMEFVKTLGLRMDYEYLTKGYLFTKGNIKIIINNITRTEKIGTYDPNVLKPLSDSLLIEMSVALPDTKEYMTTAKALRSFADQLSPICDMQKVEYWRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5U0</accession>
    <name>A0A183I5U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15102</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041615">
        <property type="protein sequence ID" value="VDP20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5U0"/>
    <dbReference type="STRING" id="387005.A0A183I5U0"/>
    <dbReference type="WBParaSite" id="OFLC_0001511301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001511301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001511301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001511301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16510" checksum="A56B7587BFC10779" modified="2016-09-07" version="1">MFLSVRTCVVVAEERPRVALCAVFSKLFAPLGLNSRAVSTSFGCRVNMAICMQGAASPDPATVYVDARALRNDRVTLVEKGAPHSIALMESGKLLPGVEIVIANPETRGQCADSHLGEIWVACSHNAVGYFTLYGEEPSLHTDHFNASQHYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I668</accession>
    <name>A0A183I668_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glyco_18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041801">
        <property type="protein sequence ID" value="VDP20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I668"/>
    <dbReference type="WBParaSite" id="OFLC_0001524101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001524101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001524101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001524101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29564" checksum="991FBCFCD59FDDA7" modified="2016-09-07" version="1">MQPLRPILKLFQVFSNTSTIFAFRKNNYCIFYLKKFLRPFEWNDEDTNWSKGMNSRVTKLKESDPNLKILLSYGGYNFGSATFTAIAKSAEKRKHFIKSATAFLRKNRFDGLDLDXXXXRKHFIKSATAFLRKNRFDGLDLDWEYPIGVAKEHGKLVKEMKAAFVKEAKNSSNEQLLLTAAVSAKIHTIDQSYNVRCLGKHFDLLFLKSYDFHGSWEKNVDLHAKLRPTKGETSGKCIFNTEFAANYWVSKGMPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6M3</accession>
    <name>A0A183I6M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15385</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042045">
        <property type="protein sequence ID" value="VDP21620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6M3"/>
    <dbReference type="STRING" id="387005.A0A183I6M3"/>
    <dbReference type="WBParaSite" id="OFLC_0001539601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001539601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001539601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF36">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001539601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38932" checksum="F6D4EBF2AB52D1CC" modified="2016-09-07" version="1">MLYHKKVVDLCPEAIDSLSCIVRYGLKEGVYISHRNRTIQAWLKAQEAIAEQKHYDAISHLSSVPPGNLKIMIELGRLHYTVGENQKAAVYLRRAHHLDSNTSYSMDILAFILAQVDKFQEQNFKDLENLAATLMDAQETPEAWVAYAFLAKCQKRYDKALYFTEKACKLADWHVHPMAILLRSLILMDKKKFDEAIAELRDALVIHPANYALYEALVHAFLLQEKIQEARIIACTCRHILGQDNARALYLSATLAAKDESTVKDAQKLLEKAIAISPHLLDAVFLLVALYDKTQNYEKAIALLKKQTETTVNSRLHRLLGDFLTKTNRPVDACHQYRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7M6</accession>
    <name>A0A183I7M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042742">
        <property type="protein sequence ID" value="VDP23542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7M6"/>
    <dbReference type="STRING" id="387005.A0A183I7M6"/>
    <dbReference type="WBParaSite" id="OFLC_0001575101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001575101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001575101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001575101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11836" checksum="02A773863767E2E2" modified="2016-09-07" version="1">MAINIFTDRLMQHFDNILFCRVGIRMDKEDECDNMSCFNLVPSVYLSVLSDCIPPMLDLALKGHTGMVDISNPTPLDDYDFRELCNQGNRPDGGASVKIVCSFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8B2</accession>
    <name>A0A183I8B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15973</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043417">
        <property type="protein sequence ID" value="VDP25518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8B2"/>
    <dbReference type="STRING" id="387005.A0A183I8B2"/>
    <dbReference type="WBParaSite" id="OFLC_0001598701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001598701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001598701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001598701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15604" checksum="C5CE7BC3ADD753C2" modified="2016-09-07" version="1">MNEFQDCTELLEKRVRSRLSNSLISFAQSSISFDDFSKTFALFLHTNVKKYKQNNDLIQPFVADECVERKLHEIYDETRSYCILKQITATFLCFMDAEHIESLASPQASRIFTEAKNAIISNEDTMKSIILSENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U009</accession>
    <name>A0A3P7U009_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000467">
        <property type="protein sequence ID" value="VDO28200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7U009"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="461"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="553"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="634"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO28200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="756" mass="81537" checksum="E51C6AA5E5B8188F" modified="2019-02-13" version="1">MISFCFQCERTKERLQRDNESLRQEIEALRNQLYNARTAQYHFRLHSSPMILPVAASPVPVQSPSGPGGPPPPPVVAVTASTGAAVYGGIRRTQKGRLQALQEDPSKVQTLNEQEWDRLQQAHVLANVQHAFSSSSSMVDMTGGGGGSTACPPGPNTATMSGTADPHTLANMLQERLNAINSEIRLIEQEKTHAERIAEQLESRATAVAAAAAANEESQALSTHSTPRNSPQHDFLATKYNTLPANASTSHIHGDNSSGPMDSSYGHQFGAVDEMPNGVATFDYGMRGRRYPGVADQMQHSYTGPLLDDEYNPSSGLAPLGILMDRLSPTSSITSSQYDHSPVYGTPATAKGAKKQRSTSSTAAKTLGRLFNKKAKSSSCGSNLRQLAQFDQGGYSDSETSVEGIALTSGAATSTSLLTGKSVNGGVILGAAAAADFDRRKKKKYELLEEAMKARTPFALWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMSALSDQEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPRTTRATLAFGEMNHEWIGNEWLPSLGLAQYRPAFMECLLDARMLEHLSKRDLRTHLKMLDSFHRASLQYGIICLKKLNYDKKTLIERRKACENVSRDVLVWSNDRVARWVEEIGLGAYASQLKDSGVHGALIALDHTFDAQSLALSLQIPPQDFSARQLLEHAFEQLLVAVDCRSSTTTFGTGTSGADCRGSIAAVNAAVTAASTIATGTGNYSSVPPPSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U9N8</accession>
    <name>A0A3P7U9N8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001070">
        <property type="protein sequence ID" value="VDO31530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H3D9"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="238" mass="27209" checksum="AD0C833E625CEDB5" modified="2026-01-28" version="1">MLKVEDFDSATENEVQAKKLWRNADAVCFDVDSTLCTDEMIDEFAKYLHCYEVIKFTEEAMNGKISFRESLKIRLNILKPTQKQLEEFIREREPKLTPGSEALIAELHRRFVPVYLVSGGFVPMILPVAKALKIPETNIHANEMFFDENGFYIGFDEARETSDSGSENFGKAAVCRKLKDEKGYRNLVMIGDGVTDLETSAQADLFIGFGGNRCREVVKRKASWFVYDFDTLRKSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UDI9</accession>
    <name>A0A3P7UDI9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001303">
        <property type="protein sequence ID" value="VDO32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UDI9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="150" mass="16871" checksum="B952F5FE76469DA6" modified="2019-02-13" version="1">MKPITSYFRYELSRHRTRPPSTGIERRTRLLVVDNSALGKEANTSGKLAYCIDVYKPGGRKKHMPHATLGDKILVAIRGEMKQAFVVGAKIHVDYRKHGIPSTDTNNIVLLDDEGNPLGTRVLMPIPAILQRKRANLQFSKILSIATKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UYU1</accession>
    <name>A0A3P7UYU1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="1">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01003563">
        <property type="protein sequence ID" value="VDO40451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UYU1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi-associated nuclease 1-like TPR" evidence="2">
        <location>
            <begin position="218"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="427" mass="49271" checksum="8C75D3760FD4091B" modified="2019-02-13" version="1">MQVFCSGGQYGEVQFWGEHLHLNFIALSDESKQLLIRLFLRKRKWLIADKLSYVNISSSLKPLFEELLQAKFIDSSCSSQFGIEEAVHLLHASSLKAVAKHFRLDFNKGKIELCRSLLKFATQKNVFGITMEKRVLHKIKEELGSCFRLRKDIMDIFLAIFTIYSPMDMSTSLLFDQPSINLSSQLLFVLLQLGIDKLRFPAPHNPHMINIYTDAEKLFRYVKAKELEAEIADLTQRGKWNEVIECAKKARTEFQDAYAMQWQFYESLNGHLRRFTDLHVYARCISHGVEALERVRDYEEAVAWLEYMLHAIEFKLILANARDAHLKDKDKAMKAVIAGLEDPVLGDKDRLSLQDRGRKLCSGWKGPLEEVHPEKINIKGSVVGKNLGEARINRFLVERNGVSYECSVEDVALDYYLREKGFKEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VC60</accession>
    <name>A0A3P7VC60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003777">
        <property type="protein sequence ID" value="VDO40959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VC60"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="142" mass="16444" checksum="04B9C1FAED1E9F95" modified="2019-02-13" version="1">MTDFARKYEKGQVGNSNKEDLIRHLTIKRDKKLETLHQQRKERERLQTAELVDRQAKEMLELFKQARVECDDSSYRGSPSYPATPPPPQPPICSKRDIYTNTMVFEAIDEVAITMAQSEITTFTELIRTLTANARNDIEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VFE5</accession>
    <name>A0A3P7VFE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004184">
        <property type="protein sequence ID" value="VDO41979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HC68"/>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF111">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="183" mass="21581" checksum="9261DDDAF30C3FF1" modified="2026-01-28" version="1">MSQQCFPKDRKQTRARKRREQNVLFYELKRKAANERERKRMYSINEAFDKLRHLLPWLSRDRKMSKASTLREAIRYIKQLNQLLNGEQVNSENTSQQCGIAVKSETAGSSLVIPNSDDRLPMKFVELSCSKIPDDYDSIIRTEYGTVQGRCSKVWIPSICEEMVNFENYDCLHHRYLLPINEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W9T7</accession>
    <name>A0A3P7W9T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005063">
        <property type="protein sequence ID" value="VDO44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W9T7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="172" mass="20063" checksum="028D1D3130D26B87" modified="2019-02-13" version="1">MEKISGENNKLREEIEELNSRIRASVEAAEGLQKEINDKNEQLNSITKQINDAEWSVGEHRQWLKDANNRISELESALTEKNHFIEEMQKYNEEHCASEELIALQAKLQIAEKALDEAPKQEKMNELSSLVDHLQNELNNKNECIKNLEKQCNDTEWSLGEHRQWIHDSNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WLB2</accession>
    <name>A0A3P7WLB2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calsyntenin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004892">
        <property type="protein sequence ID" value="VDO43693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WLB2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF2">
        <property type="entry name" value="CALSYNTENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calsyntenin C-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO43693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="184" mass="20608" checksum="5D75BF94226717E9" modified="2019-02-13" version="1">MQNAIFLTNSPSFTLKANTAEDLSLLLQQVTYTNTKKLPTPGHRTFSINTTVHCAGGKTLTLNPSKGSISVHREAESVISISGLSIVNNDQHLVKTGAPMLPEIKITVTQKINGGKFRNFRILRISKLIFDKEIDRTSVSELDWCKVHLKPSRDMDLEYFSSPASLIAALRIDFEHDKQARYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XN03</accession>
    <name>A0A3P7XN03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000908">
        <property type="protein sequence ID" value="VDO30782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H2S8"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="478" mass="55127" checksum="664AA616CF9865B9" modified="2026-01-28" version="1">MADTTSFYDVGGYRENVRRYKDGIEQLTDIQTMIKERMDIETSYSKCLQIYYDKWSDHVDGLAKSAIQAVWKDVLEESMELQRLHANVRDRICDEILKTVTLYLKENHHPSAFRASKETREVEDDFERAQRSWRRQFEKVEKAKKAYHGSARSERSAQIQMKNAYGDAALSPDMQSRYHDRYQKCQEELMKSEKVYRSALDDLYLLKKNYVSHMNDVFEACQLKELKRLKFTFEMLSNLQKVCSDLASATKLNNLHRNLEKKLTTDNTRFNNDLENWSKKYGPECETKWPAFEPFIPSLNSITSRKKKKDGEVVLMKQIFKDVDGQNNSFYSTKSSILQNTQLTAPNTSIKASIPVVAEIIVDRTNGILSKNKTTITQNCEEPTSSISTHSHNDQSSLVIPERDNASNNPGESSPTEDVKHLYTAKVLHDYDAQDDDELSLTKGEKIIVISGPDHLNWSLGMKNERTGFFPASFVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y3Z0</accession>
    <name>A0A3P7Y3Z0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002256">
        <property type="protein sequence ID" value="VDO36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H7D6"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="273" mass="31420" checksum="F5E38DE7974F7259" modified="2026-01-28" version="1">MKKIRLTHESEGVPCTALREMSLLKLLKHPNIISLEEVILDEQLVYLVFEFVSMDLKKHIDKIPYGELMKKAEILQGICFCHQRNILHRDLKPENLLVDGNGGLKIADFGLARQLEFAYREYTDVVVTLWYRPPEILFGSSNYSMGVDIWSIGCIFAEMAMKTALFKGDSEIDQIFRIFSILATPKEDVFGMQNLARIKALFPDFEENKLQKILANYMDEDGIKILRTMLSYDPKARISAKKLLKDPYFNDVDRKKLPAGDFDGSIPPRPWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ABJ9</accession>
    <name>A0A3P8ABJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039859">
        <property type="protein sequence ID" value="VDP11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYG0"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="379" mass="43634" checksum="1FBB55CB65A11843" modified="2026-01-28" version="1">MLVSDMASRSSIDQTFPPKGTIKKEKKDESFFDKLGTLGRKKKSQQLEQEAENEAIEVETEGAKAIDSTVIPVSATLQNIMLEEGEEKRLLTMESRDDPRVQEVIQLLIHWLNYELAPQRIVVKHIQEDLYDGQIIQKLTEKLANIKIEVPEVSQSEEGQRQKLHKVIETVNRIIAQGQYEKAKWNADLIHNKDTVAIIQLLVAIAVFFRAPVRFPEYVNAQILVVQKKDNQLKSRYSTEQLTTTQPELGVKGERDAFDTLFDYGPDKLAHVKSSLLAFCNKHLNKINLEVTDLENQFKDGVYLVLLMGLLEGYFVPLYNFDLQALTYDQKIHNVTFAYQLMYEADFQRPRARVQDIVNGDLKSTLRILHSLFTRYKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EJZ3</accession>
    <name>A0A3P8EJZ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RhoGEF domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS12804</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039939">
        <property type="protein sequence ID" value="VDP12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13329">
        <property type="entry name" value="PH_RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08756">
        <property type="entry name" value="RGS_GEF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="675"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="913"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1291"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDP12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1317" mass="148751" checksum="C46AE9A642228193" modified="2019-02-13" version="1">MQSTVSLIQRCVVVTRQVDGYGLTVTGDHPVFVHTVKPNGAAFYAGVRQGDKILKVNGMPVTASNHLEVVRMISGGQTVALTLLGPPPKPVTMDFREVLQMRAHESKPIISEPVLVESLRETSVEGIQLERALQRIESLQNQLRNIEPVITQEKWTVNSGMHFVHPVEIIAMEEETDSDGSEIPFNLEAQGPFLNFADLKTRPAHLAAFINYLLANANPSSAFFYLITDAYQNSYAAPKDLRKWAYEIFSTFLIPNSPLSWDNIDQSLIQSIDKVLAATVHATDNDVDQLIMIFSLARKKSLDDINEHLADFRQKRLIGLGSLFDANQLAYISKGDTAMETRVGEAILIRSLENMLNSVNQDLENCESRSLAVISALATVIKVVLNMRSNTNEKILDRCPTFVTKDKVGMFRMKMATKRSIQVKGHQFMLNAVNLTVYCYQCRDAVWGVNAQAYFCQNCDVVVHKQCTSSLPDHCYPAIQKKTGANKTKRTGSAGKSEMELFEGTSSLADQTHSTSIITDKELQRIDNVKSTSSDSGIGTDMEKPVSRSQSMRSRPDEMQDDRRGRSAFSWGGALALPEEGEELPRRARSDMDNEDKASPVTLNRCPLDAVSLSGSSSVSHASGGDEEVRRLMDKIEKNSLLDGDSDLEIDTEVPSLESFVGWEIVRRLKPKEKKRQEVINELFHTERTHVRNLKILYKVFYKPMILQGIVPPEVIKLFFPNLEELLEVHGNMSRMMRNMVEEWKRDCDLNGLLGDVGSLMEDLFDRENGTKLVEATATFCQHQQHALDILRQRCKKEKDDQLSRFLIEAECNPLCRKLQLKDMLPVEMQRLVKYPLLLETIAKYTQEPSEEQTKILNSVNSAKRILSAVNTAKRNAENLRRLEELQKRLVTTSYDRENFGNDFHSFNLTHYKLVHDGPMTWRCSRNKMIELHVVLLENVLILLTKTGDGNKLLLKVQEPSKDTRWSPLLPLATLIAKEKANDKRALFIVNTMEHGAQIYELVTTTATERKTWFKLISDQIDLVKRENINAQPNIAPFGMNATDNGQYQREDMDFCERAQISTHPRLVNANEITIQQPTVLEHAQPVLIPTERLRRNDELIVKALLDKQTILAEFLPGSNKNNLAELEKLTEQLTGMAAAELKQRDGQELAMSAIVHGNRLLDAINQVQQMDRFYLFAHQKKKIEGLSARKDTDKSNSDTVLLKLDNVENDVPTVACYKLTAIAAPLMNHLKAMLQVIQDQQSEIKAIKQQLHQYKELAIGTNQTDSEETVTESTDYNQIISDAEVERRKRLQTKRQRNTVVTLSAASIHPHSPTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FQA2</accession>
    <name>A0A3P8FQA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043079">
        <property type="protein sequence ID" value="VDP24383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FQA2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="126" mass="13783" checksum="FA125EE2D0921A5B" modified="2019-02-13" version="1">MCRRVVLHYSNAVILSVDNETIVIFKKSVSLESLNLGPRTAGDGADDEESLTGTITSGECIWQDNYEDDGDASRCGVSEKHAMEKQENPAEIHANPEKKDESVTEGNNVKVFEKSLAFSSWIGGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXS8</accession>
    <name>A0A183GXS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MABP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS38</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MVB12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000009">
        <property type="protein sequence ID" value="VDO24301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXS8"/>
    <dbReference type="STRING" id="387005.A0A183GXS8"/>
    <dbReference type="WBParaSite" id="OFLC_0000003701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000003701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000003701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046755">
        <property type="term" value="P:viral budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019075">
        <property type="term" value="P:virus maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.100.10.50:FF:000002">
        <property type="entry name" value="Multivesicular body subunit 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018798">
        <property type="entry name" value="MVB12A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040297">
        <property type="entry name" value="MVB12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31547">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31547:SF1">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10240">
        <property type="entry name" value="DUF2464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MABP" evidence="9">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="UMA" evidence="8">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO24301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000003701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31003" checksum="95860B50670FD7A3" modified="2016-09-07" version="1">MSEVLMMRSSDMGDENNINPITSVIIVADKNRCPRGFTPITRTFDEQNDADLWRESSFTFFSRPVRYLAISRDTPQNTVGTHVVTDLCVVKDSDPIPMGFIAIDYTADSKEKALRKRYLCVRTVARDAVVDAVGEIILLSKMRKPPKNYSSAGEVDGILICFKHIVIPSSFGITIPRSRSTTSMLYPSVGNDDFRHSNPTLDKTKTNITINALTIKAGVKRGVEDVPFRLNPQVESTLIKNKLEMLPELKKCDSEQLDRDYCYYFTLERAMLSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXY7</accession>
    <name>A0A183GXY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS97</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000022">
        <property type="protein sequence ID" value="VDO24516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXY7"/>
    <dbReference type="STRING" id="387005.A0A183GXY7"/>
    <dbReference type="WBParaSite" id="OFLC_0000009601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000009601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000009601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO24516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000009601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30811" checksum="B107A3B470432C05" modified="2016-09-07" version="1">MEVFGRWTAYGTFGKTIRLLFFITQLLSIVTFLFHGKNMVLLAVLIYGCWLVQNRSQYAELLEPSLYVDVARIMIVSSVFVFISASVSVYAVTKEMRCFIYSYVTASGVIFVMMFIGGVMGFVFRHQLQHKIPLHLKMLTSLRELYGLPEMEGITYAWDELQSNFNCCGVNGTDDLRVWKKSKWFMHQKGSKQKLPVSCCVNEMVQYCLETDLYHPDETVVHTRTCYMPLRSDLLKVMHVAAWLLIIASIIMVMPAVFAGIYARLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYQ9</accession>
    <name>A0A183GYQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS369</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000115">
        <property type="protein sequence ID" value="VDO25558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYQ9"/>
    <dbReference type="STRING" id="387005.A0A183GYQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000036801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000036801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000036801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000036801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15581" checksum="8FEBEBF0BBEA7165" modified="2016-09-07" version="1">MSIDLLSKVQPDLLMNDSSNQTSHLHPLDDKKSLNQAVYKKDLEAPKHLTINRNDHELLSEHSRMRRTVADVIDECRTVGGNAFAEQFLRELKAASQINRGPPGISRGSHLHWDLLLGKDETIEPSDYLNFDYTAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYY8</accession>
    <name>A0A183GYY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS448</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000147">
        <property type="protein sequence ID" value="VDO25833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYY8"/>
    <dbReference type="STRING" id="387005.A0A183GYY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000044701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000044701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000044701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000044701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41737" checksum="EF1C7C0F684F99D9" modified="2016-09-07" version="1">MTSMKQWRHQSLEADGTSQKSMEDKDSELVANGYDEESVDDEDTKQPSSVCRAEKSLGILTQRFVDLLQRARGGIVDLNIAAEELQVRQKRRIYDITNVLEGIGLIEKKSKNIINWKGGKLRKHGSFPDNDPDEQKRILKRKAELEELEKEERILDTHIKWMKQSLRNVSEYQKNMKLAYLTEEDILSVFEDSRVFAIQAPPGTFVEIGAPPRMRDFDVQYNLRMKSTFGPANAILLGGINSTRSQGNLFTNKSQPMPYAVEGDVPGQFLEEDEDESLLKKRRLDEEFSDQSDPILPFIPSQGEHQKSSQQECSSLQSQTQTSPTFSQEIREVMRKLSPPPSERDYIFSLSQGETLPDLFEDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZH2</accession>
    <name>A0A183GZH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macro domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS632</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000223">
        <property type="protein sequence ID" value="VDO26479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZH2"/>
    <dbReference type="STRING" id="387005.A0A183GZH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000063101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000063101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000063101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000063101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21633" checksum="0ADD936C5F08D4B2" modified="2016-09-07" version="1">MAGIKKWSEATTAAELTKSNNPLAKFIAVDKGDITKLEIDAIVNAANSSLLGGGGVDGAIHRAAGRCLYDECKKLNGCKVGEAKITKAYDMKHIKHIIHTVGPQVYSEVTEDQRNLLKSCYIESLKIAAANNLRTIAFPCISTGIYGYPNDDACNVVVTSVLAWLEENKGKIDRIIFVTFLDKDYDLYEKYLKEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZW0</accession>
    <name>A0A183GZW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000295">
        <property type="protein sequence ID" value="VDO27003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZW0"/>
    <dbReference type="WBParaSite" id="OFLC_0000076901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000076901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000076901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000076901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15456" checksum="CECEB20281E9FAB7" modified="2016-09-07" version="1">MISIFLFPKLNSSLFKLVSTDIDNNEDDTTGYCGTNAQEKSARHRTINPPSVIHPLIRLSKDSAPHLSTFIQPNQTKVMPTFGNTPHVMMVRYCHLGKRDQKLQDIALITYSMRFSKDIEKKKGKGGKEKAIFKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1D9</accession>
    <name>A0A183H1D9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1299</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000588">
        <property type="protein sequence ID" value="VDO29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1D9"/>
    <dbReference type="STRING" id="387005.A0A183H1D9"/>
    <dbReference type="WBParaSite" id="OFLC_0000129801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000129801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000129801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000129801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14787" checksum="7063600D5916096C" modified="2016-09-07" version="1">MAPSKKGSKQERKPRSAMSEVVTREYTVNLHRRLHGVGFKKRAPKAIKAIRKFAEEQMGTKDVRVHIRLNEFLWSKGVKNVPFRVRVRLSRRRNDDESSADRLYTLVTHVPVTTFKKLTTVNVDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1R4</accession>
    <name>A0A183H1R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Cation transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">OFLC_LOCUS1424</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000665">
        <property type="protein sequence ID" value="VDO29485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1R4"/>
    <dbReference type="STRING" id="387005.A0A183H1R4"/>
    <dbReference type="WBParaSite" id="OFLC_0000142301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000142301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000142301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514011" evidence="17">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="130"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="303"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDO29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000142301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="556" mass="63927" checksum="BF2271D92ED31806" modified="2016-09-07" version="1">MDRWMTFLEISCWIISIAWLLPSGGQCGQDAGRLMEDLLSDYNKLVRPVENDTDTLIVRLKLKLSQLLDVVCDLTVLFLIMLIKHAQIHEKNQIMTTNIWLQHVTFFIFFNLKINSFTLDNVTLPILIIDYGGVTVLYVPSDMIWLPDIVLYNNADGNYQVSIMTKAKLSPNGTVEWSPPAIYKSMCQIDVEWFPFDIQTCEMKFGSWTYGGLEVDLQHRDSHIERAETETLLGFDGEYDETVWIVDEGRIDLSDYYPSVEWDILGVPGKRHLKRYPCCESPFIDLTYEIRLRRKTLFYIVYLIFPIVSINFLTVLVFYLPSDGGEKISLCLNILISLTIFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVTLSVIVTVITLNVHFRTPTTHTMPEWAKKVFIEFLPKYLLMRRPSPIKVIRTSSTNTFITPKRPDRRLSTFSRPRDHTISALFDQMDFLSPAYRSSFCTTRSHDGSSFTSFQKELTPVMSAVDSVTFIANLMKDDKSVQEIIEDWKYISVVLDRLFLILFTTACMIGSIVIILRAPTIYDTTIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V3</accession>
    <name>A0A183H1V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1463</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000693">
        <property type="protein sequence ID" value="VDO29633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V3"/>
    <dbReference type="STRING" id="387005.A0A183H1V3"/>
    <dbReference type="WBParaSite" id="OFLC_0000146201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000146201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000146201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO29633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000146201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69949" checksum="76EBEDC9FF11F2B0" modified="2016-09-07" version="1">MKIIWESDDWPGCVVDSKITCLNWIPNGNNADTGLLATGKSFQSIYLPIFYTLHQILYIYFPGSESGAVGVTATEACPLRDDNRRINFNLRGHHTTVNIVAWNKEQMKLASCDNSGIIYVWVLNEERWSVELVNDRGIKVRGVSWSPNGSSALICYEDNFVLIGSATGQRIWSSSFPVGVNCGVWAPDSREIVLGFNNGSIQVLNEQGATVTERKMYINGSVRFLAASSRRKNGRWTLAVCSITGLLNFLNSYDEIDNAKWQCNETLLSIQWNANGTLLAAVCKENHFFIMTYQGNVICDSRVSQPSATGLIAFTWVHDDRFIIATSGNQLAVGRVLHDVPSLFNLVTYNLWQLLGASARNVDLLPLPPRERNAIRALDHHVIRCRVPSQNDMLMKVCEPSNWRWYCTIRPVPSKVHTYVLCMEHMAGLIPLLLGKQTNRIIPQFQISLYNPRLTLIKSDSGSSAQVEDVGAFARPSTQRNSVWRRSKRHLRALMKRYVNYPVSRSNGKLVQITSNVWCTRFKMLSVTTNILPTFLAQVVYKTSLLHLQPRQMTVQLADLTKRTGNPLISAHYAAYRYPRNGAQLSNNNDFSNENSIRSVTVAPCDRYVFIFKIFFLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H239</accession>
    <name>A0A183H239_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thyroid adenoma-associated protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000748">
        <property type="protein sequence ID" value="VDO29940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H239"/>
    <dbReference type="STRING" id="387005.A0A183H239"/>
    <dbReference type="WBParaSite" id="OFLC_0000154801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000154801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000154801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000154801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55682" checksum="5824ADB7DF004477" modified="2016-09-07" version="1">MAETLPKYVVLYCLLSYLQNVGLPAIQYSAVRIGKPLTKIPVGSDEAAVMCLFDQALSESNYNDKLLEIVQKFQNPAISAISCEKLAEYCVKFINKLDVGNMWHSVVLAVRYWSDKQKDRYTSGKVLELHQVASSKERNFIEVLHQLSGEECWNDIISFFIRKMIISMMKTRPVSVAQHGLNIRCVLLCTRILLQDDSNNEMLISVRNFLQHLIERDSSDRVVPMMCYSIAIVPEIVDKLLLEESEQFEPVRRVMSLHLASRDELFTIFSKVIMSRLLNKSTYSTTCLQKVNIDSFHGWFAESINMIVTDISGLDLESMELSPRLLSTMMTCNALFCLATNRLVPNKEILVFPMLNECIRIISGYFESEEKDVTSFKERNEMFADTTGLQSLSNMLIRTILRLLLFGRLMTSFVRNTECSILPRVANLTEEIYRFREFTRIKLEQEGRTAANRLLYFGLNDWLRVMKPWTKYLQAAFTVEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2K5</accession>
    <name>A0A183H2K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1715</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000863">
        <property type="protein sequence ID" value="VDO30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2K5"/>
    <dbReference type="STRING" id="387005.A0A183H2K5"/>
    <dbReference type="WBParaSite" id="OFLC_0000171401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000171401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000171401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000171401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13933" checksum="E3C5910855AB2F64" modified="2016-09-07" version="1">MDDECCVCVQRRASVRAFPCSHKVFCRNCAVQLIEHAINENKMRMSCIICRRDIARLQYSRPSRSARIRKQQALLDSNSSNTTSATATFATARVLNNAVCCSPEVFSKYPCQTFPTPVTFSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4S4</accession>
    <name>A0A183H4S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2484</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001437">
        <property type="protein sequence ID" value="VDO33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4S4"/>
    <dbReference type="STRING" id="387005.A0A183H4S4"/>
    <dbReference type="WBParaSite" id="OFLC_0000248301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000248301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000248301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000122">
        <property type="entry name" value="polycomb group RING finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000248301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20414" checksum="99461245C6A67140" modified="2016-09-07" version="1">MSRKPTLIGDEYKILLKTLNPHITCPLCKGYFIEATTVTDCLHTFCKSCLLKHFENVNNCCPKCSNLIHQAWFLMSHPSHYVSFDRTMQELVYKLVPGVQAREEENQNAFLQTVRTESGENGKLEIDENAVNSNSEARECSGNLIDKHHRSDEQVAVELCTDKLSKFSDIEMPYLRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H555</accession>
    <name>A0A183H555_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001537">
        <property type="protein sequence ID" value="VDO33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H555"/>
    <dbReference type="WBParaSite" id="OFLC_0000261401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000261401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000261401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000261401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8054" checksum="24075B0EB1EF503E" modified="2016-09-07" version="1">MVEKGHLRIFLTLCNQHQKLQRPHPLDMTLLSFLVQISIQQRFTIMMIVFLHYNSIVRKHQKPLLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N3</accession>
    <name>A0A183H5N3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2793</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001696">
        <property type="protein sequence ID" value="VDO34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N3"/>
    <dbReference type="STRING" id="387005.A0A183H5N3"/>
    <dbReference type="WBParaSite" id="OFLC_0000279201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000685">
        <property type="entry name" value="Serine/threonine-protein kinase dyf-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36087" checksum="29FF72A3AEA8FBDD" modified="2016-09-07" version="1">MHKNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSRPPFTDYVSTRWYRAPEILLRSTSYNSPIDIWALGCIMAELYMLRPLFPGTSEMDQLFKIITVLGTPNKEDWPEGYQLAVAMNFKFQQCVPIPFASIVNSVGDDGLKLMTDMMLWNPEKRPSAVSSLKYRYFLVGEKLGAPAVSQPSTSNRETSASSTLSDSCVLLGKAKLKTNVSETKIDVGNGDTVLDKNSHTISGAVVMKTKLPAKELYMSKSRYMPGIMINPINQQSTDPTKRSSLKPNPARSAVQARFEYAYGYVPSFGVRKNPLNNTSTKPSGRIDWTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H699</accession>
    <name>A0A183H699_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3010</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001887">
        <property type="protein sequence ID" value="VDO34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H699"/>
    <dbReference type="STRING" id="387005.A0A183H699"/>
    <dbReference type="WBParaSite" id="OFLC_0000300901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000300901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000300901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059031">
        <property type="entry name" value="SH3_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26085">
        <property type="entry name" value="SH3_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="STAC3-related SH3" evidence="9">
        <location>
            <begin position="237"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000300901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32447" checksum="021D357977BCDECC" modified="2016-09-07" version="1">MCSVDSKIYVTFENKRESKTDAIDPVYLALKQATGIYGRRGSSTHNFDSATPSPRNLSDASLQDSGYAEASCNRGVMISSTPQLDQSGMNGGKRRPPKLQKQMKSLSLDCADSPPSIASGVYSRNKLAPTLLHYNNSSGDISEYERSRSSSGPSPLLTPRRISSSDALSRYSSLAVLQGSHVVIHEYIAEPDTALCLGDRLKVVDNGDPDWLYGFKTGDRTDRLLTFPSTCVALVQPGEQPMLLKQNVHIPEAKMRLYRDQVVFAQPDSITSGRVLVRTERHAFVQCPLQHLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6I3</accession>
    <name>A0A183H6I3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3095</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001962">
        <property type="protein sequence ID" value="VDO35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6I3"/>
    <dbReference type="WBParaSite" id="OFLC_0000309401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000309401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000309401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000309401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17018" checksum="E49ADF55B453A0CE" modified="2016-09-07" version="1">MSFRNVKFDDSGRIARSKTDIGASAGDTVVCQHTLLPVDGYDMSCAPIQTMMNCFGERKKKAMSSSSLSSSRHRAQSDPTKLPLLTFRNPSVSCVWNICLLRLRCDKSRIKFGFLRSIHVRIDVDFNDRSVRRSHCSRSEEEEEGEEIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8P0</accession>
    <name>A0A183H8P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3853</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002721">
        <property type="protein sequence ID" value="VDO37989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8P0"/>
    <dbReference type="STRING" id="387005.A0A183H8P0"/>
    <dbReference type="WBParaSite" id="OFLC_0000385101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000385101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000385101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000385101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11901" checksum="3BF2E3E92F188A79" modified="2016-09-07" version="1">MMVANAQNLIITVKPANQRNTLQRGVHSRISDWSGTSEETLTAQRRDNNNDMHSSNGALSKGHRNNNELSDEDSDEDIVVDHTKENTDNTISESHHHHRYQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAR5</accession>
    <name>A0A183HAR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E1-E2 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4578</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003539">
        <property type="protein sequence ID" value="VDO40388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAR5"/>
    <dbReference type="STRING" id="387005.A0A183HAR5"/>
    <dbReference type="WBParaSite" id="OFLC_0000457601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000457601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000457601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="7">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000457601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41230" checksum="9D7D08D1837889C4" modified="2016-09-07" version="1">MLSLATYIIHLIHGNNEPVNLYCALILISIVILMCFVAFYQEKQTLQVINDLKSVLPTSCIVIRDSKTQQVPEEELVTGDLVVITAGAIIPADIRILQSNGLKIETSAVTGDKEAYDYTHEAVATYLSIFEARNVAFKGSFCLEGDGIGIVIRTGKYTVLGYIINIHQQVSKTRSKLKMEIDEFVNFISVVALVMAIVFFLFGSFINNFKNVLDHFIIGFLIIIVANVPQGLPAMVISQLAIIGRRLASKNVYIKKLDIIDELGATTVVATDKTGTLTKNSMVLTDLWYNRKHHPNHNYVNNQSVLNMNCPKPIIEQPLSDMFVVMSVCNRAHFECARKSKHSTSEKEAQKKSSGKMLNMGQVSKRFIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA0</accession>
    <name>A0A183HBA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4764</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003788">
        <property type="protein sequence ID" value="VDO40976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA0"/>
    <dbReference type="STRING" id="387005.A0A183HBA0"/>
    <dbReference type="WBParaSite" id="OFLC_0000476101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="242"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="429"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58985" checksum="DCFD29754249F94B" modified="2016-09-07" version="1">MEITASSEGHGIISRLVDGIFKQIGTSDRYRVTASMLEIYEEKVIDLLCVNRECLQIRESKGVVQGLSVHPVSCLEDALKLLQKGCQLRSRGETAMNDKSSRSHAIFTLCIEGSETKENTMFKTKLHLVDLAGSERLKKTQAEGERMREGIKINEGLLALGNVIASLTDQNASGRHIPYRVTKITRLLQDSLGGNSYTVMIACVSPADTNADETLSTLRYADRAKRIKNKPIVNIDPNMALIQGLRDELASVKHELAMLRAGENLITLEDNQITTKQCKKCAELEKQNQESQENYNRHRVRFAEAIAENSKLVEQLLASQQIVEQLKDHMKEIKQVSKNENKEFDEAMKILDTAINLRGPIEEEKDKDMLDIGEDDGDDETSDQTFVNHFTEKQIALNKDMRNILEEIKQKELAFEATVASQTEIVKMRDTYAAEMEQLQAKLITLEKEKQELLSKLKGSSIHHKLSEERRKRLQELEKELATSKRRMGEIQRLEKENIRLQEQSKKLSTELSFFTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBW8</accession>
    <name>A0A183HBW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4422 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4977</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004065">
        <property type="protein sequence ID" value="VDO41651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000497901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000497901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000497901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000497901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5271" checksum="B8DC7E726AC208A7" modified="2016-09-07" version="1">MYTMIDIKVYNGLQQLRYKPGAESRFFIICNLCIIILSITFVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCQ1</accession>
    <name>A0A183HCQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5264</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004435">
        <property type="protein sequence ID" value="VDO42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCQ1"/>
    <dbReference type="STRING" id="387005.A0A183HCQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000526201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000526201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000526201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000526201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="41089" checksum="D80E9D0AC01E0695" modified="2016-09-07" version="1">MQLSGLDLAIYGFNRNIRKVEKAGISYELCIIRDKLTLGLSTEPILKQSSTVDCLAENWTSLDSAEGNGTDVTAVQDFMDLDDEQYLSFLKSLDPKHCKDQDHYKVLGLSNLRWQASISQIRTAYRAKVLKHHPDKNNAVRVEAGGAEDYFTCITKAYEQLGLSEQKRRAYDSVDPLFDDSIPDEKMISPVNFYDILTPVFTRNARWSIQQPVPLLGDSSSAQVEVDRFYSFWFNWNSWREFSYLDEEDKEKGEDRWERREIEKINKIEREKRRKNEMKRIRNLVEMAYRKDPRVALFREQEKLKKEKQRDERRKALEEKKALDEKKKLVMPGLSLRFSNGTIFCKEQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCX5</accession>
    <name>A0A183HCX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5337</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004531">
        <property type="protein sequence ID" value="VDO42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCX5"/>
    <dbReference type="STRING" id="387005.A0A183HCX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000533601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000533601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000533601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000533601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55079" checksum="4B126AE744FC6B34" modified="2016-09-07" version="1">PTVLEIANFELFSSGPQNIRILGSERYPSNEWMALGNFILENNREIQRFPIAARSYVKFLRLELLSHYGREHYCTLSLVRLLGISMVDEYEAEAEAAAVSDTSFSIPVVSILSITSEVRIIFGFHFNIEAVNNTAAEKMNAAVTSNNIAKENISVMPEIVEKNESVNDLPFVNTVVNAVGSIGIGNIKDVFQSTFLMKRTRVSPQNVTRNNATLIELCTKCVVDSINNYVLFCRTFFGYQYSFIDADNANLARNKQVHIHSFLKHQKKKNRTRVLEFFFASVLPTNICNLESRSFENVQNLTSYNLTESDVISTISPTINSPTTSNLLNRNLNGGEKGFGHFVTDERFMIPGGVMSHKESIFMKLNKRISNLELNMSLSSEYLSELSRRYVLQTNESRRQAELIIKQAEEAAVNAIKSSVHALKIQMDALAANLRELTETVKSLPELATPMHHTMVLKHSVDKGSDSDASLARSQAYVYSHLGMWTVCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDG2</accession>
    <name>A0A183HDG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5521</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004791">
        <property type="protein sequence ID" value="VDO43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDG2"/>
    <dbReference type="STRING" id="387005.A0A183HDG2"/>
    <dbReference type="WBParaSite" id="OFLC_0000552301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000552301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000552301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000552301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="21922" checksum="28D6DD7B43F25E9E" modified="2016-09-07" version="1">MEPSRLMTILSTLFSTVSLLVIIIVLPSFFTYIQRSNTFMLSELNKCYINTNDVWKNVVQLQFSTQTRKRRFDGVSVNDYPCCSCQQGKPGPPGEPGNPGQDGIDGPPGFPGRDGKPGQHMIPPKGSQNTCQKCPTAPPGPPGLSGRKGLRGPRGAPGIPGVDGPSGRKGPPGPMGVRGPPGPFGSKGPPGDPGRILSGAPAGPSGPPGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE72</accession>
    <name>A0A183HE72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5784</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005158">
        <property type="protein sequence ID" value="VDO44318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE72"/>
    <dbReference type="STRING" id="387005.A0A183HE72"/>
    <dbReference type="WBParaSite" id="OFLC_0000578301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000578301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000578301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="154"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO44318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000578301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26154" checksum="CDC48F02732DB551" modified="2016-09-07" version="1">VVTTFKVVTKKVARPIAERKKWKKFGQCKNDGPGPHVSTTYVAEEVLMQFIRNRAGEQQLDIGDEGTKVTTTAGGSFTHCRYCKVGSFKSDEHWSVSCPYKSMYAKDDEEDLENKEKDTKLGPAVPGSGKYVAPGMRGDRPVITGGAERRSEENTCRVTNLPEECDEMELRALFGTVGTVNRVFIAKDKHTNKPKGFAFVTFEHRSQTEAAIQKLNGYKLDHLVLKVEWTRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE77</accession>
    <name>A0A183HE77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5789</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005166">
        <property type="protein sequence ID" value="VDO44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE77"/>
    <dbReference type="STRING" id="387005.A0A183HE77"/>
    <dbReference type="WBParaSite" id="OFLC_0000578801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000578801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000578801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000578801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17897" checksum="7A65F2740DCF66C1" modified="2016-09-07" version="1">MPVFQKKTKKSVQNPQASAKRNQRLIFSAQKTAATRQLSCVSANRPSSRRVAHSQKASGKYVEMTGTDFQRDREKEDQAVQDLVEHLKSIAPFNKRWQVIETINQGTYGVVFSVRDVITKVYGVIKVAKSMANEAGNVSAEWEGFILETMFKRVQFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEC4</accession>
    <name>A0A183HEC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intermediate filament tail domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5836</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005236">
        <property type="protein sequence ID" value="VDO44504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEC4"/>
    <dbReference type="STRING" id="387005.A0A183HEC4"/>
    <dbReference type="WBParaSite" id="OFLC_0000583501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000583501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000583501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1260:FF:000003">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF6">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="6">
        <location>
            <begin position="237"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO44504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000583501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41420" checksum="7016A18443A22DF1" modified="2016-09-07" version="1">MQDLDEETLGRIDFQNQVQTLMEELEFLRRVHEQEVKELQALLAQAPADTREFFKNELALAIRDIKDEYDYIAKQGKQDMESWYKLKVSEVQGSANRANIEANYQREEVKRMRDNIGDLRGKLGDLEAKNALLEKEVQSLNNQLNDDQRQYEAALNDRDATLRRMREECQTLVAELQALLDTKQMLDAEIAIYRKMLEGEESRVGLRQMVEQVVKTHSLQQQEDTDSTRSVRGEVSTKTTFQRSAKGNITIAECDPNGKFIMLENSHRSKDENLGEHKLRRKLDNRREIVYTIPPNTILKAGRTMKIWARDQGGLHSPPESLVYDGENTWGIGANVVTTLINKDGDERATHTQKTIQTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF34</accession>
    <name>A0A183HF34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6099</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005607">
        <property type="protein sequence ID" value="VDO45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF34"/>
    <dbReference type="STRING" id="387005.A0A183HF34"/>
    <dbReference type="WBParaSite" id="OFLC_0000609501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000609501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000609501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="3"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000609501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38108" checksum="C391F1E27E59E5C9" modified="2016-09-07" version="1">CRCAAGFTGLQCQQICSEGRFGPGCREKCRCANQAHCDPITGACRCSLGYIGAICEQPCPDGKYGPNCTLDCECYGNAKCDPVQGCCDCPPGRYGTRCQYELILKVERKTLPFGNEFWESIPNRLIIVLKIRKKFLACPAGFYGWYCSQSCDCQNGATCDPDNGQCRCLSGYFGKQCEQSCANNTYGPHCQLNCDCGKFQCDPETGKCDCPLGLHGPKCKQDSSKKTVAENIILISTRQEELFNLFCVSLCLHCNANAINSITFRFSMIIPKSDLSFVACRPGRYGKNCEYRCECYNGAICDRVTGQCTCAPGYLGATCQHEQFDIESVAKRGDLPEYDFRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFZ3</accession>
    <name>A0A183HFZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3517 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006061">
        <property type="protein sequence ID" value="VDO46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFZ3"/>
    <dbReference type="STRING" id="387005.A0A183HFZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000640401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000640401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000640401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000640401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29829" checksum="115537400EA8E6B2" modified="2016-09-07" version="1">MVVLYLLTAPSTDVSIPKLPKVRYFFTNIFVILLNATAHDYPDVIRPYMRNSNFENIHINCSNVTVAGDCPDFKIDAVYKAGDTISDIFITLLLIIPRNYFTEFSAHPTQYIALFNLYAMSGLEQKRQLVRKGALHALLVLISRDDYHIKVIYQDSSKLYEVISLLLRICKFEWQGENADLNPYAITTGGLIQAPQEVAQWMDEPVFVNRLLKQLIEFPTDRAVALDTILYLCWENIRFTKILLYHFSFEVHNCCNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG62</accession>
    <name>A0A183HG62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6475</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006171">
        <property type="protein sequence ID" value="VDO46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG62"/>
    <dbReference type="STRING" id="387005.A0A183HG62"/>
    <dbReference type="WBParaSite" id="OFLC_0000647301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000647301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000647301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000647301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3481" checksum="6ED425A031B4CECD" modified="2016-09-07" version="1">MTCATDTTNIQFVFDAVTDVIIANNLRGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG72</accession>
    <name>A0A183HG72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6482</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006179">
        <property type="protein sequence ID" value="VDO46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG72"/>
    <dbReference type="WBParaSite" id="OFLC_0000648301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000648301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000648301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000648301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5634" checksum="2B3BDE42142E7AB0" modified="2016-09-07" version="1">MGREVQCSMSNMWCVVLWFGALWYTAYIVGAMVYCDMIWYYVARFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGQ2</accession>
    <name>A0A183HGQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6664</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006470">
        <property type="protein sequence ID" value="VDO47373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGQ2"/>
    <dbReference type="STRING" id="387005.A0A183HGQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000666301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000666301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000666301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000666301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8317" checksum="A998F2F6167077F7" modified="2016-09-07" version="1">MLPSSDTDDDDECDDENDEKKNEDNSMSDSSDLAESEELYEVDETQDSDDEDGSNRNDFAFKIYNPNRLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGX3</accession>
    <name>A0A183HGX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3077 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006583">
        <property type="protein sequence ID" value="VDO47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000673401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000673401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000673401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000673401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7849" checksum="CAC6423C9BF158B7" modified="2016-09-07" version="1">MSVMQDKALITNYTRPTCPDYFTNLTDEARRINYAKSTCPDNFRNVTEASMILSAIAARRILADISKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH38</accession>
    <name>A0A183HH38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006679">
        <property type="protein sequence ID" value="VDO47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH38"/>
    <dbReference type="STRING" id="387005.A0A183HH38"/>
    <dbReference type="WBParaSite" id="OFLC_0000679901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000679901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000679901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000679901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13056" checksum="59312FEDA1C69E48" modified="2016-09-07" version="1">MSAMEVTETPTAESEQMKEQIEEVQQQKVEETKKEETPTQEEATKAVENTVSHPSAISENTESSAESEKKDAPQVYDLDLFFISFHFIFFYRHNQKEQSPFFLLFFIVLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHC7</accession>
    <name>A0A183HHC7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6888</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01006833">
        <property type="protein sequence ID" value="VDO48278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHC7"/>
    <dbReference type="STRING" id="387005.A0A183HHC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000688801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000688801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000688801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO48278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000688801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15150" checksum="81034099509CA360" modified="2016-09-07" version="1">MMSRSRLYTSEGYDDSYHIISVIGRGAFGVVLKATHFQSHEEVAIKRIPLKRNSRNEISLIREVFALRNAYHKNIVRLFDVILNTDAVSLVMEYVGSSLKLAIEDFNRPLNDEIPRYYMHQLFIGMDYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHE4</accession>
    <name>A0A183HHE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6905</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006863">
        <property type="protein sequence ID" value="VDO48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHE4"/>
    <dbReference type="WBParaSite" id="OFLC_0000690501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000690501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000690501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000690501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11432" checksum="E6BED9F4E3DB7FF8" modified="2016-09-07" version="1">MTFQTFQGDIVSCFLTPIDGQQKVLHLAPDKKKIENLPECTAGFVSIKKDIADVEGTDADNAFLVSASRLTNSISDRSECDLNFVFHSIFNVALPFIYSTATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHE9</accession>
    <name>A0A183HHE9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nipped-B protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6912</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006873">
        <property type="protein sequence ID" value="VDO48403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHE9"/>
    <dbReference type="STRING" id="387005.A0A183HHE9"/>
    <dbReference type="WBParaSite" id="OFLC_0000691001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000691001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000691001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO48403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000691001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37422" checksum="9BE11F074865A59E" modified="2016-09-07" version="1">MSRYFDLDAILGKDEEAKKFLDSSVSALSSFSPSTELNKEHDEEEKQSAKSSTFVEMIFQVLTTFCRYRDGDIRLKALNAIGNFTATNSKYLTRMELRNMYMTLLGTDDKEYLGLKIQTLKNLELFLSAEETKMVKNNSEWHISKEEHDLKEMELANSGLASATIQLYWNAVLNSYYNSSDAVRIAAVQVAILTLSQGLITPGSSIPTLIAMSTDRNTVVRNKVENMLREIDSKYAGMSKAIAGIRCSFRLHMIIKKDPDSVLRGIRACDQTITTSDSNDNSKLVNGVPKMTNDGQALLSGLYQNLRGNRQQRRSFLSSILRLFSEDSREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHL7</accession>
    <name>A0A183HHL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6979</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006985">
        <property type="protein sequence ID" value="VDO48712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHL7"/>
    <dbReference type="WBParaSite" id="OFLC_0000697801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000697801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000697801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000697801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13935" checksum="42E0FAA2B47E4B37" modified="2016-09-07" version="1">MPRHHVATSRDMQRSRGRQREREMGEGQRDVSPIAIDSVPEPEWVVSSGGARQRCGRAGAGAKHAVKLQHAKSPYPAVVLYPGYYMWYACACLHSFGVTNSCLHIQHMKMKCALFDDDGVKCFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI77</accession>
    <name>A0A183HI77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 194B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS7188</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007330">
        <property type="protein sequence ID" value="VDO49733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI77"/>
    <dbReference type="STRING" id="387005.A0A183HI77"/>
    <dbReference type="WBParaSite" id="OFLC_0000718801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000718801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000718801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552542" evidence="9">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO49733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000718801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26530" checksum="47DBE506AD9EE27D" modified="2016-09-07" version="1">MLVGRVVNSGWTIGQITVLFLLFHQITADEDTSEKCITRELTTSYIVVPEKVSEWSSASTILDIYHCNRFRRHVAHMFMDVYVQINLTNEHAYQLYQGKNCSEVMQHYHDDQRLWGLVRRVKLLCYKQLNPFSKTIIGVSTRHPYEIRIRVWKINYIRLALFIGSIALFLMSHSLVKNAIFYYTSGCTIGVLASLLIVGFVIYRMTPKVCFKKFTCNLRLLVFNSFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIP3</accession>
    <name>A0A183HIP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007637">
        <property type="protein sequence ID" value="VDO50624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIP3"/>
    <dbReference type="STRING" id="387005.A0A183HIP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000735401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000735401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000735401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000735401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16801" checksum="B3425E91B75F857E" modified="2016-09-07" version="1">MFQRQAHKKALSSCVVDEASDVARHFSKDQLRHLFNLKTDIASDTHDSLKCSRCVNGIEYREPQEYADTNSDLSEWYHVQKDVRKVPDKVLKRIFECGVITFVFHQKSHDVKSEIMKEEDVKSEIVKEEDEIKENDLLNEEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ01</accession>
    <name>A0A183HJ01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007815">
        <property type="protein sequence ID" value="VDO51129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ01"/>
    <dbReference type="WBParaSite" id="OFLC_0000746201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000746201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000746201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000746201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9581" checksum="78F648B4800AC585" modified="2016-09-07" version="1">MICPFRSQYNCSYSRAVCYLSFPARNQPLVASTTMDDIIDGRDGFVGYVRSARSERRDKSTGYVKDVRSGRRDRSVGYVRAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJW8</accession>
    <name>A0A183HJW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008343">
        <property type="protein sequence ID" value="VDO52483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJW8"/>
    <dbReference type="STRING" id="387005.A0A183HJW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000777901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000777901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000777901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000777901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34300" checksum="BA74BDC7DDBFCA5A" modified="2016-09-07" version="1">MRNELIMIKNRNNRLIEQLREKSMEHSKLTTQMSTLQKQIGILRNRCRLNEALEKLSINDRMITRATATIDSVEKKLKFFDDKLQAVKAEMMKNSQAIINQSFREQNAYQSCLEHIERLQRDNFSMIQDKSSDIGSHDQRVRQLLEIMPSYDALYSFTISLVRKLGQLRASYIEKNIYANRSDFEVMRAQSSLLLIHAQLERLKLQLYEATKRRPSRPASYHGEDLLQKTIKPQMNFLLPFKLHGSRIRKHRRSDSCVMESEVEKNEQSIENEFLRLFDYARCKSFFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK48</accession>
    <name>A0A183HK48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7861</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008493">
        <property type="protein sequence ID" value="VDO52889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK48"/>
    <dbReference type="STRING" id="387005.A0A183HK48"/>
    <dbReference type="WBParaSite" id="OFLC_0000785901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000785901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000785901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000785901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22875" checksum="A082C0DFB9394E0D" modified="2016-09-07" version="1">MQSNDGSGQCIPAMFNLGNTCYANSLLQGLASSKAFVKWVQMIDTKLPYEGHKLVFLDALKQVIQELNDATKEMCSASDVIDALLAHRWSIPPNTEQDLYELFNVFVTTWDEELAELRHNRDLPLQKIIEIQHENNISLSSLVNDEKPLTNGVNITRRNIGDSVFVKDNEKRVDDAVSLNNADLNLSSDSHSLSLSSLSFEHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKN8</accession>
    <name>A0A183HKN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8052</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008826">
        <property type="protein sequence ID" value="VDO53811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKN8"/>
    <dbReference type="STRING" id="387005.A0A183HKN8"/>
    <dbReference type="WBParaSite" id="OFLC_0000804901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000804901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000804901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO53811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000804901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28044" checksum="3537003D615A122E" modified="2016-09-07" version="1">MKGTVFRQIDTATGTPKIGVHQGLLNKGDVYAGGNADDFRRLFNIRDREVLYIGDHIFGDVLKSKKTKGWRTFLVIPELVKEISIWSQRHDLFEKVLEMTKQVEAMYNQVDVSSVQSTIQEGNTQIREKTQEMDNYYSKMGSLFRSGPRTTFFASQNLKLKRKKEKINCANAYFFFSKVERFADLYSSSCYNLLYYPLFYFFRARMTLMPHEVNINKCIQKKTLPLNVPSELIKSLQKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM57</accession>
    <name>A0A183HM57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8572</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009821">
        <property type="protein sequence ID" value="VDO56334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM57"/>
    <dbReference type="STRING" id="387005.A0A183HM57"/>
    <dbReference type="WBParaSite" id="OFLC_0000856801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000856801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000856801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000856801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12758" checksum="B3AA69C53652FF33" modified="2016-09-07" version="1">MGHKFNFSSIITPNPDSESVPIDLSKKHASDDLDRKSILEDKSNLLFDPLQTIQSHQQQLLELYAQLAASHSRHTDSEQSSDDGGNTSSYVQSPPSSNGIAEKIHPCVAERCPQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMK2</accession>
    <name>A0A183HMK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010081">
        <property type="protein sequence ID" value="VDO57030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMK2"/>
    <dbReference type="WBParaSite" id="OFLC_0000871301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000871301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000871301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000871301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="6174" checksum="725687EC813F8465" modified="2016-09-07" version="1">MIINHEVPSLNLKLMLVVLLEHQLIYILMLLAVFRCHNSVDISVMQMVEKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMZ1</accession>
    <name>A0A183HMZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8853</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010356">
        <property type="protein sequence ID" value="VDO57734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000885201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000885201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000885201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF189">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000885201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20703" checksum="5B1069C7A46851A5" modified="2016-09-07" version="1">MPLTINNIFGLLGHTIGSHPVLFIFLSLSLFSISLLGPLLRLDIRVDIKSGFNRDDTASMQEISAHKLFFNNTGEPWYMALFAIANNGSILETGKTDELTTFYKYITEIMPINVNKSTVHYQNDLCEPFCDFNSQLWNLLNYRSFFKIFYPLTTVGPYKVNIGRYLFNRTTDERGFIFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMZ2</accession>
    <name>A0A183HMZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010362">
        <property type="protein sequence ID" value="VDO57752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMZ2"/>
    <dbReference type="STRING" id="387005.A0A183HMZ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000885301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000885301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000885301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000885301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12934" checksum="74AD84D37C55E95F" modified="2016-09-07" version="1">MAEVKEESIGITRLKKELADIQKIKLKLYELEDAGKSDPNKWLVLLLPDRWPYNVGGYKVEIEFTKDYPFKAPKIKFLTKIYHPNVNENGEVSLPMVLNENWKPSIKIDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN70</accession>
    <name>A0A183HN70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8935</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010512">
        <property type="protein sequence ID" value="VDO58092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN70"/>
    <dbReference type="WBParaSite" id="OFLC_0000893101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000893101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000893101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000893101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8131" checksum="313632C657BE11D0" modified="2016-09-07" version="1">MPAVNRLLNKYYFEVIIFICLLSSIDIIGFKHSQSLIANSAIPQKNARWGQFALLPPELITINFCAYIHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN77</accession>
    <name>A0A183HN77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fascin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010522">
        <property type="protein sequence ID" value="VDO58123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN77"/>
    <dbReference type="STRING" id="387005.A0A183HN77"/>
    <dbReference type="WBParaSite" id="OFLC_0000893801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000893801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000893801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000893801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26417" checksum="531F8F51EA46BDC2" modified="2016-09-07" version="1">MIGRASLYRSEKDFTVFTVTHCGCYFYEYSNGDTRWIHSSKLYQVNYYGQAGATTVKVGEGKLLVRHFLTGQLEIYRESGETTLMTSDGRRIEIVKDKSKSVRIEMYAFSYELDGKVHVRGRGEVETEYRATQTSCHRMDGSYASHIASDGSIEWRSPDYTVHRFKSGDTKVRLNSINTSITMLVRDVGTVKHLSNPLDRRLPKYCVEWGTVARNRSRVIAATQSRVLNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPN1</accession>
    <name>A0A183HPN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9441</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011568">
        <property type="protein sequence ID" value="VDO60624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPN1"/>
    <dbReference type="WBParaSite" id="OFLC_0000944201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000944201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000944201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000944201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6778" checksum="17F59B5087F85CAE" modified="2016-09-07" version="1">MKESKNHLAQILRIKTSTGFTPIETILDLPCLAVAVQAEQYPTFMANDSDTVTAHQIDSGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQB1</accession>
    <name>A0A183HQB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9673</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012121">
        <property type="protein sequence ID" value="VDO62355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQB1"/>
    <dbReference type="STRING" id="387005.A0A183HQB1"/>
    <dbReference type="WBParaSite" id="OFLC_0000967201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000967201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000967201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO62355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000967201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19716" checksum="3ADCB4870A50298F" modified="2016-09-07" version="1">MTKYGAKDKKRNEFEMVLDDEKIDFIQAFQMPGTSDTEKEVVSVAQKKKLTLAETRKSLPVYAYRDEFIQAVHDHQVLIIEGETGSGKTTQLPQYLYESGFCANKMKVGCTQPRRVAAMSVATRVAEEMGVKLGIEVGYSIRFEDCTSEKTVIKYMTDGMLLREFLNEPDLASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQF9</accession>
    <name>A0A183HQF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9721</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012236">
        <property type="protein sequence ID" value="VDO62779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQF9"/>
    <dbReference type="STRING" id="387005.A0A183HQF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000972001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000972001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000972001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO62779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000972001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17733" checksum="EBCEE2A7E03E582F" modified="2016-09-07" version="1">MVKGDQWYGYDNEETIKIKMRWLKETGYGGAFIWALDFDDFKGTSCGKGPYPLLSAINGELESESTVSTESSETTTVTSEPTENGRIQTTTSAVEPTGKPSNVECPEPYGIFKHPTDCRSFIHCAHNYAYVFHCPPKTFFNDEIKVCDHLWNAPITCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQS1</accession>
    <name>A0A183HQS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012504">
        <property type="protein sequence ID" value="VDO63761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQS1"/>
    <dbReference type="STRING" id="387005.A0A183HQS1"/>
    <dbReference type="WBParaSite" id="OFLC_0000983201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000983201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000983201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000983201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8322" checksum="5177643001728B1F" modified="2016-09-07" version="1">MVESIISENELKVPSCGLPQIYRKYAPDKSRKIHLPEALALNPGTLSNFHKDCLACTGNHFTGLHSAINKFIPSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRZ0</accession>
    <name>A0A183HRZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013471">
        <property type="protein sequence ID" value="VDO67109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRZ0"/>
    <dbReference type="STRING" id="387005.A0A183HRZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001025101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001025101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001025101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001025101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19486" checksum="D263F1D43A795FFD" modified="2016-09-07" version="1">MGEEWRGSQAASRCPFLNSNADLNTIISHNALFCDRCRDEQILEKTKGEEILFVNNPPYWILPSKNEESRDNEEDQYQKTDISDDGHSVSLKDFTQKRQGITTISGSRVQGKKFENTEKLRKWKNESEIPDTPETSHKSNRSAKQESEKQEAKVPTNIALHKLAKQGYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS77</accession>
    <name>A0A183HS77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10339</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013680">
        <property type="protein sequence ID" value="VDO67710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS77"/>
    <dbReference type="STRING" id="387005.A0A183HS77"/>
    <dbReference type="WBParaSite" id="OFLC_0001033801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001033801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001033801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057001">
        <property type="entry name" value="RYYR-CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23674">
        <property type="entry name" value="RYYR-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RYYR-CCHC" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001033801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16164" checksum="E24DDE8D3331880B" modified="2016-09-07" version="1">MKNEHVDGETEEDQSGIAHEAEIMSGRFKHPPLIIFEPDSQAARIYRINGKSDKLGIIYYRCSKCDVLCRRHRRMGNVEGMTRATVKVEEDEILENMYPAHHEECEVFTLDMVKNLAENLDRFYFAKDYEPVIHDSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSC9</accession>
    <name>A0A183HSC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Complex1_49kDa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10390</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013799">
        <property type="protein sequence ID" value="VDO68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSC9"/>
    <dbReference type="STRING" id="387005.A0A183HSC9"/>
    <dbReference type="WBParaSite" id="OFLC_0001039001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001039001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001039001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001039001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12903" checksum="D65E77D24891BF3C" modified="2016-09-07" version="1">MVMKAVPHVGLLHRGTEKLIEYKTYTQALPYFDRLDYITMLTNEQGFALAVEKLLGIEIPLRAKWIRTLFAELNRIANHTFSIVTHALDIGAMTPLFWMFEEREKLFEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTA2</accession>
    <name>A0A183HTA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10715</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014591">
        <property type="protein sequence ID" value="VDO70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTA2"/>
    <dbReference type="STRING" id="387005.A0A183HTA2"/>
    <dbReference type="WBParaSite" id="OFLC_0001071401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001071401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001071401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-amylase/branching enzyme C-terminal all beta" evidence="1">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001071401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13899" checksum="B98D8B03612944B4" modified="2016-09-07" version="1">MLHFIHFSFEGNEFGHPEWLDFPRVGNNESFHYCRRQWNLVDDELLRYKYLNNFDRAMNSLEEKHSFLSRGPAYTSWKHQDDKVIAFERAGLLFVFNFHTNKSFSDYKIGIEVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTF9</accession>
    <name>A0A183HTF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10769</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014739">
        <property type="protein sequence ID" value="VDO71195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTF9"/>
    <dbReference type="STRING" id="387005.A0A183HTF9"/>
    <dbReference type="WBParaSite" id="OFLC_0001077101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001077101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001077101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001077101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12712" checksum="CDFFFFA19797943C" modified="2016-09-07" version="1">MYGFNGGGFNKCATLVSRQYSAFVLGHIQILWCIAMLLCPILVNAMIGEGTIYDWRMIFLLHAFLSLITNVYFCFVAASDAAWWTDDERVKSRMISGDTFWWWKNEPQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTN3</accession>
    <name>A0A183HTN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014914">
        <property type="protein sequence ID" value="VDO71736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTN3"/>
    <dbReference type="WBParaSite" id="OFLC_0001084501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001084501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001084501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001084501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5987" checksum="D03F39554FB859D9" modified="2016-09-07" version="1">SIIIAFFHFSIQFWGGQIILLLGQLLQQQKLTSAILSKLRIKSWKKNRSAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU47</accession>
    <name>A0A183HU47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS11004</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015337">
        <property type="protein sequence ID" value="VDO73037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU47"/>
    <dbReference type="WBParaSite" id="OFLC_0001100901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001100901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001100901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO73037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001100901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18549" checksum="45E264E7D59C7081" modified="2016-09-07" version="1">MFNASVLPRICKMIKWIYVENSRMRSVFIVEFISSILAICIALLTLLAIIFNKTLHFNMRLLLICFWGAIIIACIGTLIDSSYYLIAIISKMDAELCAWLSFTQSDCIALRNVYYMGLLMIVVSTLFLSVERVIATLFYQTYERNPCKWISISMALSQISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU77</accession>
    <name>A0A183HU77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11036</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015410">
        <property type="protein sequence ID" value="VDO73291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU77"/>
    <dbReference type="STRING" id="387005.A0A183HU77"/>
    <dbReference type="WBParaSite" id="OFLC_0001103901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001103901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001103901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="3">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO73291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001103901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15216" checksum="AF5C339CD8F9D133" modified="2016-09-07" version="1">MGRERVAIPVENGTDDGATLDSNFEYINAVDDHDSFQTHIDFSLACRCSDDCENDCPCLARCTYDADGYLTSRAIELAIRAELGVLLECSSCCFCSNKCKSRVAQKGVHCELEVYRTRKYGWAVRTNSLIRKGKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUG9</accession>
    <name>A0A183HUG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Not1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11131</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015672">
        <property type="protein sequence ID" value="VDO74112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUG9"/>
    <dbReference type="STRING" id="387005.A0A183HUG9"/>
    <dbReference type="WBParaSite" id="OFLC_0001113101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001113101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001113101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001113101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25438" checksum="DE50D1910AAE58C7" modified="2016-09-07" version="1">MRLPDPFGSNLKVDSLLEMTQEPKMNINMAAIIPPDLRTQLDDYLNTRSSVDFHANLPSLLQVSNIAGSKYNTTVMNAVVIYVGMRAIQTIHEKQQCITMTTIAHTAYMDIFQNLAVSLCTEGRYLLFNAIANQLRYPNSHTHYFSCTLLYLFLEANTEIIQEQITRILFERLVALRPHPWGLLITFIELIKNPSYGFWKHDFVRCAPEIERFLFITFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUU9</accession>
    <name>A0A183HUU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Auxilin-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016052">
        <property type="protein sequence ID" value="VDO75180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUU9"/>
    <dbReference type="STRING" id="387005.A0A183HUU9"/>
    <dbReference type="WBParaSite" id="OFLC_0001126101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001126101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001126101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001126101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20304" checksum="B02CCBD37C319AEB" modified="2016-09-07" version="1">MNDPFFAGLNFKSLLRQKAEFVPELKGEEDTSYFDARTDRYNHDVDSGDEDNAPMFGFFDTASPRHSIISTESINMAQVANFDSVKNSRSDSSSVSCQLSGDFHENKVGIKYNCPLTAVSLFSIFATVYWFIGLKFDNFSSICKMVLVRDNFICKNLVLFHIKAIRVLSFRKLLLRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV72</accession>
    <name>A0A183HV72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016388">
        <property type="protein sequence ID" value="VDO76055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV72"/>
    <dbReference type="STRING" id="387005.A0A183HV72"/>
    <dbReference type="WBParaSite" id="OFLC_0001138401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001138401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001138401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001138401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6531" checksum="479124ADFF65408C" modified="2016-09-07" version="1">MAFVESEMADVVPIPLTQYGERLSVDGSKTKVKSRIKTNNRRELWRRHTLSDIDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVK8</accession>
    <name>A0A183HVK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016706">
        <property type="protein sequence ID" value="VDO77038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVK8"/>
    <dbReference type="WBParaSite" id="OFLC_0001152001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001152001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001152001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001152001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9434" checksum="8D86BD5083677B1E" modified="2016-09-07" version="1">MDSNASFEVTLLERWNDLTSAFVPELKEKWWKHLASIYKERAFHNFKHLNDMFQLFDEYKHKFQDQMAIAFAIFFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW57</accession>
    <name>A0A183HW57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017298">
        <property type="protein sequence ID" value="VDO78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW57"/>
    <dbReference type="STRING" id="387005.A0A183HW57"/>
    <dbReference type="WBParaSite" id="OFLC_0001171901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001171901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001171901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001171901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12622" checksum="2DEDAFF395120EE5" modified="2016-09-07" version="1">MSKRSKKDRSLPPAASPPDLLTPSTVLKVGETFIVLRRAPNKNGLTDERCLATIVEIRDGEQPSTSSASISAVDNTTTTATTLSSVNYLFLIHMDEYTIKEIIGEVELTQNTHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWK8</accession>
    <name>A0A183HWK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MBF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017718">
        <property type="protein sequence ID" value="VDO79996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWK8"/>
    <dbReference type="STRING" id="387005.A0A183HWK8"/>
    <dbReference type="WBParaSite" id="OFLC_0001187001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001187001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001187001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001187001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6763" checksum="936790F19AAA033E" modified="2016-09-07" version="1">MWRAREAAQQMQEQGANFDKPAIQILKRPQGCEMQSSSSQHDMAKLEEKARSMTLQVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXF2</accession>
    <name>A0A183HXF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12159</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018519">
        <property type="protein sequence ID" value="VDO82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXF2"/>
    <dbReference type="WBParaSite" id="OFLC_0001216401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001216401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001216401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001216401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3341" checksum="4B879BA845A85570" modified="2016-09-07" version="1">MAELRRLALNEECSTTQLREMINSMLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXM4</accession>
    <name>A0A183HXM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12238</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018749">
        <property type="protein sequence ID" value="VDO83088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXM4"/>
    <dbReference type="WBParaSite" id="OFLC_0001223701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001223701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001223701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001223701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10562" checksum="6B89BC023624DCA1" modified="2016-09-07" version="1">QAGKGRGKKIDNSSSSIPSQFIHLPFLFFPSEHSCGDNRSLTKLVFPPNRLSSSSSSSSSSSSSSAAAEAALFNPSKSDPILTPDPIFEGMGKKVKSDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYL0</accession>
    <name>A0A183HYL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin-27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12572</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039872">
        <property type="protein sequence ID" value="VDP11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYL0"/>
    <dbReference type="STRING" id="387005.A0A183HYL0"/>
    <dbReference type="WBParaSite" id="OFLC_0001257301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001257301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001257301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001257301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36375" checksum="858B7DC8AA7F16E3" modified="2016-09-07" version="1">MMGDESDSSEDYFVVSTRHNFNPKPHLVTVVKSDTGFGFNVKGQVSEGGQLRSINGELYAPLQHVSAVLRGGAAAKAGLLKGDRILQVNGVDVEGATHKQVVELIKDGGDKLSLVVISVDAVDAERFENGLTEESCASCRQLLKIHFYKCEDNNVFAFLYDYSEKRSLPITIPSYQTITANGERFVAYNVHMAGRHLGSRRYNEFVQLHNLLKHEFIDFDFPKLPSKWPFSLSEQQLDARRRGLESYLEKICAVRVIADSDIMQEFLMEDSLSECAVADVHIRILLPDGNSLLLNIKRHCTAIQLYMVIFYFICLTSTIFFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ6</accession>
    <name>A0A183HYQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12618</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039884">
        <property type="protein sequence ID" value="VDP11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ6"/>
    <dbReference type="STRING" id="387005.A0A183HYQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001261901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="28798" checksum="B95D8159E0D2AB4F" modified="2016-09-07" version="1">MDCSLWPRYAAAAAYNPAGTAVPSPAAAGAASAAAAAAAAAALYTQPFTSVIGGSKPKVATPKVVQTIAAYKRANPTMFAWEIREKLLEERVCDVENVPSVSSINRIVRNKSTMNRLAERTLQQTAFLAPTTPYSINELLGFEQPSKSSMDNSQIAQQLATNFKTATKNAFTSRFHASLEKGWEGTGHTVIASSNTNSQTYFDGFLGDRWTGSMQNPECITASGIDLNTNQNSNRGNADSNMPFTASMRTSSSFVLYSSTNNTATAASSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ10</accession>
    <name>A0A183HZ10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynactin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12722</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039914">
        <property type="protein sequence ID" value="VDP12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ10"/>
    <dbReference type="STRING" id="387005.A0A183HZ10"/>
    <dbReference type="WBParaSite" id="OFLC_0001272301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001272301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001272301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein associated protein" evidence="8">
        <location>
            <begin position="196"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001272301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30909" checksum="6B0C235319B345E4" modified="2016-09-07" version="1">MKSFVKRTIHAFIKMRDVTGQMVVDKQEITKENERLKDELASLTKMCEKLKKDSDAYENIIAELRERVDVAMGSEKMIETLTAKNLDMEEKVRALEETIDDFEAIRAMDEEILETQKDVEKELREELDRSCGKISELFLQIKACGAQAEDYEKTILMFRKKVNDLNEELQERYDENLRMVEQIKLLEKGSTVPGISFSATRTFSEIVDAEVRSLELEFANQYTKYLKAFMPDNFAKPGGDSDAIILNVLFPRLYQKSMILAKLMSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZK3</accession>
    <name>A0A183HZK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plexin_cytopl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12915</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039974">
        <property type="protein sequence ID" value="VDP12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZK3"/>
    <dbReference type="STRING" id="387005.A0A183HZK3"/>
    <dbReference type="WBParaSite" id="OFLC_0001291601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001291601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001291601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plexin cytoplasmic RasGAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Plexin cytoplasmic RhoGTPase-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001291601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52574" checksum="3087D740E0849993" modified="2016-09-07" version="1">MKQQMEKGPQDALTLEARYSLSEEKLLRASFDFRKLTVFIAADHHSSGAMDYPVRVLDCDSITQVKEKCLDAKYRTTAFSDRPSVNDLDLELRSGCPRIILQDIDSTSKIEPGGWKRINTLAHYNVPENATLALLPRQASLYNLSILSERSTFSLPKQSPTLTRPFGTNSSSQCKGLLSNMDSNYKLYHLVRPSEHGSSDQQDKMVTEIYLTRQVLSLKSSHLVFVQKLLTMKGTLQKFIQNLLEVIFSSSSPNSAIPCVKYMFDFMDDQARNHGIEENEVVHAWKSNSLPLRFWVNLIKNPHFVFDIQKPTKLEGCLSVVAQTLMDACSTQEHQLTKDSPSSKLLFAKDIYQYRDWVDRYYAEIREMPPITDQDMNALLAEESRSHSRDRYLEQYKESLREELDMNQFAVNQKLPQKFQDMLNTMECMGEYYSNGGNGTTGTFGNRVYRGRPREDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZQ1</accession>
    <name>A0A183HZQ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein L-isoaspartyl/D-aspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12963</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01039993">
        <property type="protein sequence ID" value="VDP12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZQ1"/>
    <dbReference type="STRING" id="387005.A0A183HZQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001296401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001296401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001296401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000027">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001296401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="44735" checksum="FD1B6AE2F5D6ACAA" modified="2016-09-07" version="1">MSFPQNVSNSMLVNFLKKLSCDLVLQLLIFIETGNIKDERVEKVMLSVDRADFCPRNSYQDFPQQIGYNATISAPHMHALALELLKDHLSEGSKALDIGSGSGYLTVCMALMVGRRGRVIGIDHIKELVDLSINNINKHHSDLLMDGRLKMVTGDGRSGHKADAPYAAIHVGAAAQKLPDIKNMAWRSHGDSNASLVENLRRNGLFRDERVKMTMLRVDRADFCPRNPYLDNPEPIGSNATISAPHMHAAALERLKDHLTEGDKALDIGSGSGYLTTCMAYMVGATGKVVGVEHIRQLVDLSISNIKKNHASLLEGRILIVEGDGRRGFPQYAPYNAIHVGAAAPNVPDELLNQLAPGGRMLIPVGAAHADQRFLQIDKDGKGKVTVNDLMGVVYVPLTNKENQIGRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZT8</accession>
    <name>A0A183HZT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GIY-YIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13000</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040005">
        <property type="protein sequence ID" value="VDP12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZT8"/>
    <dbReference type="STRING" id="387005.A0A183HZT8"/>
    <dbReference type="WBParaSite" id="OFLC_0001300101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001300101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001300101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001300101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19213" checksum="230670104811F184" modified="2016-09-07" version="1">MILNNSGAKSEYTRMFADESNVICIEDEENGEESGVKCFNKFPMYQSSPKNICRSSSQKIIDSENSDTGTSDHHVSHSQLPCSSDELVQGKERKKCGKIHVAPSILDEFFGVYCLLSRSSNKYFKNRCYIGYTVDPNRRIRQHNAGKEFGGAKKTDHRGPWYTLDAVNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I105</accession>
    <name>A0A183I105_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS13417</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01040188">
        <property type="protein sequence ID" value="VDP13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I105"/>
    <dbReference type="WBParaSite" id="OFLC_0001341801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001341801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001341801"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001341801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71485" checksum="45BAD9418BA9FA97" modified="2016-09-07" version="1">MDEDEFYYENVGKHGHIVLTRKKTLEQQECVISEDDTIEYPSCREKMQWMEEGWQTHECYAFYGVNGTFCSFRIYLSEIEKYCPILPWRKTIKDDSAILFENKVPSIERDLSGLFKLMFDNELNYKFIRTRITLLWPKWLSAYDELMIKWPKTVSSRRKFNIIIHMGFLSREAGFKFGELSSTGGPLGELVQWSDLIAALYLLGHNLMISTEVRTLKKNIKKIDYKFPCPKQDGEVINLVFTDIVGLRYLRGKMSDFFNKMKCTIRVLDSFGTHAEFNSQNYFTTHKNSLGGSGKNPWGNNQLDLQQFMTMFPHTDDNTFLGFAVEMHPVNQDIKRDNVTLVYGKAGYMWKNAKQLIETVRKFTEVHATVSDNLPDFDNLIINHGVLTGSELHALMRKVKIFLGLGFPFEGPAPLEAIASGVVFINPSFNPPKSRRTSDFFKDKPTLRELTSQNPYAELFIGRPHVLTVDIENSSQVEDAIREALLSKPNPYTPFEFTILGMLQRVNILVSKQNFCHVTHFPPRQAMITVEAVSMQSRLCAAIKSISSPYAPYEXXXXLQTFRSRLCAAIKSISSPYAPYECSKQRNPDLYSCASVPTVPNIRRMCPCRDFIWGQTALCSSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1L6</accession>
    <name>A0A183I1L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13628</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040303">
        <property type="protein sequence ID" value="VDP14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1L6"/>
    <dbReference type="WBParaSite" id="OFLC_0001362901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001362901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001362901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001362901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8454" checksum="F616D6F4AB8D3233" modified="2016-09-07" version="1">MSVQVFWTDGFVYDTHARIHRYARTHTQGCLEPGHHRGRVITSRTQRVPCHAWVTLMYAYRSAEADAQTHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1U7</accession>
    <name>A0A183I1U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13709</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040350">
        <property type="protein sequence ID" value="VDP14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1U7"/>
    <dbReference type="STRING" id="387005.A0A183I1U7"/>
    <dbReference type="WBParaSite" id="OFLC_0001371001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001371001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001371001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13153">
        <property type="entry name" value="KOW_GPKOW_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041994">
        <property type="entry name" value="GPKOW_KOW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001371001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50885" checksum="9DD279364814FF5D" modified="2016-09-07" version="1">MCDFWGTQIASTSEYSCSSGMSDVSKGTSDQKSSGVKLTLSTHKRNVVSVSNNNILRTENNGSDDDMESAVNESKRQRLRLIKNGQMIESDEIQKSKSNFIIPIVRQKDWRIERLLQMKSEGKLNEEELAKLELLTEAALSSTQRSADEVDDQINKPVGNVDADYDSVPIEVFGLAVLRGCGWHEGEGIGKTNKKVVPLRISSRRPKGLGLGATIVSRSTDKSLDLDAGKLNGLKKASFVKITGGIYRNLYGRIESFDEDNASVIVQLALNDKNVRVSHYALILVTAEEYERKGKSIDRKIEEKDNEVRISQEKNYKKQKSKIIVESNKKLMWARPELKVRFIDKKFKNGKLYNEKVRILDAADRENCTVEDSSGNKYFQISEHWLETVIPKMRGKRLMIVNGPLRGNIAVLEARDKKEHMVIARLVTTDEIVTMCFDDVCEYLDSFDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2H4</accession>
    <name>A0A183I2H4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS13936</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040482">
        <property type="protein sequence ID" value="VDP15053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2H4"/>
    <dbReference type="STRING" id="387005.A0A183I2H4"/>
    <dbReference type="WBParaSite" id="OFLC_0001393701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001393701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001393701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP15053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001393701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28474" checksum="EBFD8D04F822D8D9" modified="2016-09-07" version="1">MSVECPIHPGAHLVEDHRAGDLICPECGLVVGDRLVDVGTEWRSFSNEKSGADPSRVGAPENPLLGSADLSTSIAVGFANAQRKTMNNMDRQMSQGLSVIREMSARIHLPKSIEDAAAKIFKDVLDSKALRGKNNEAQAAACLYIACRKEGVPRTFKEICAASRVSKKEIGRCFKLIIKSLETSLEQITSADFMSRFCGNLGLPHSIQAAATRIAKKAVELDLVAGRSPISIAAAAIYMASQASSNKKTARGFICDFFYTDISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2R6</accession>
    <name>A0A183I2R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14028</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040547">
        <property type="protein sequence ID" value="VDP15311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2R6"/>
    <dbReference type="STRING" id="387005.A0A183I2R6"/>
    <dbReference type="WBParaSite" id="OFLC_0001403601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001403601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001403601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="GBF1-like tetratricopeptide repeats" evidence="2">
        <location>
            <begin position="795"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001403601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121568" checksum="17BFEBB6E4D8B2B1" modified="2016-09-07" version="1">MVRRNQRPMQAECFKRNLSGTNGGQDFDPAMLDEIYNAIRQVVKILELKIWIEKKTESSVVYKINEEIVMPAEQVGIVKENYLWKVLLRRGETKEGEFIHVPAGWNDHDLFGIIWGPASAALSFVFDKSGRDTILQKVLNGYRKCASIAAHYGMSDVFDNLIIHLCKFSTLMSTNEDNPEQNLEIQQNGILNENFNQSAEQIAIAFGENGKAQMAARVMFQLVHAHGDILREGWKNVLDSILRLFYARLLPTAITEVEDFVDNKGWVSIQRAAPPKLLTNRNDSGLLSWLGLGSNYDNKESTPTADQQQLIKIAQEVVAECHPEQLIVDGKYLTSSSLSELISTIIQASTNIAHSEMDKGEPVARKLKEQEEDALVLYLEMMVSIALENKDRLSQIWTPIKQHLQWLMSNFGQNPLIVERAVVGLLRIANRNLYHLKDDIADEVLQFLGILLKLPPPAMFMFSRQIAYGLHELLRTNAANVHRHEHWTILFRLMEAAGAGVYPDDLNVQLDVELQPVLSQRKLKILDRQVHSDTEPSLNRSRIDNSETISADRGYTSDVVQESVSSFSTLTEHIDCAASSLKETSSEWVHVDHKDAALAAQQQQLQLRPTGMQNLYSNVFDRGTVVLRTNLIRHDPLAFLKVGETLSFLARDTAHITPDNFDSCIECLRSYTEASLDGGRYAAGPLSGDAQSQLRSVLKDEKSKYSAKQGHLFVKHYNVMNDKSNHRHMSLNARNNYVEEEMLSQAEPQKLSASYQQVALQILNLCYTLHVNGAKIYRSWADSGAEIDASLPALWNHCWRPLLQCIARLCCDCRRQIRTQALNYLGRAFLISEMQVMKGKEWEECFGEILFPLLQKLLENLSPMDPIGMEETRVRVMQLISKILLNHLTPLSLLASFRSLWLRLLDYMDQYLHADRSDLLSEAIPESLKNMILVMDNTQMFNTIPDLYDMTVTRIGAFLPELLAEVMPGPPKRLDLPDLKLQETSESFLQSRSPEIVNLGSREPASIFPQQLSIDRKVLIAPPIDLTHSPDSDQVESENILHNSGTVNSTDLSEVATEIPIPELVGLICFSNIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3E2</accession>
    <name>A0A183I3E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BCL7-like protein C28H8.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14254</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040716">
        <property type="protein sequence ID" value="VDP16200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3E2"/>
    <dbReference type="STRING" id="387005.A0A183I3E2"/>
    <dbReference type="WBParaSite" id="OFLC_0001426201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001426201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001426201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001426201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17821" checksum="B663E172DCA1ACE2" modified="2016-09-07" version="1">MYARSQRAETRNRAKDELKRVINSVDKVRKWEKKWIVVKDTQIKLFRWVPVTATTNITKIPQKSVVQDQDESATIASSENTQDSTVLENSDVARVRAFSNLNDDSNTGFSEGGFDSDSNQTFEAVGFQSQSNNSSTPNGSTDFSEMRQQEQESSEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3E5</accession>
    <name>A0A183I3E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14257</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040719">
        <property type="protein sequence ID" value="VDP16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3E5"/>
    <dbReference type="STRING" id="387005.A0A183I3E5"/>
    <dbReference type="WBParaSite" id="OFLC_0001426501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001426501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001426501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001426501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20378" checksum="DEBB9ACF48D252C3" modified="2016-09-07" version="1">MDTTSLGFVAVIAVLILIISIIVFKLYPKETDFEKAYGENALRLFAEDRGAKTKSAKSKNKGKNGEKKKDFGTEEKQNQGEKSANDGLFCIPLSTNSHSGIEEWNGTTGGEIHAKPNRKKSKGKQMVAGLMAESKQYIELTKDEKVARSLEELSGQWDVPEKLSTESEVRATAVILHDENKNTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3U6</accession>
    <name>A0A183I3U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14408</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040831">
        <property type="protein sequence ID" value="VDP16914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3U6"/>
    <dbReference type="WBParaSite" id="OFLC_0001441601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001441601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001441601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001441601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10563" checksum="764E656D0B1B7328" modified="2016-09-07" version="1">MESPATTAEDEGSFRAVQRKHQSVFTRKSAECSAFLSFHSSICLLERDGDESDKITVTVTKVSDKQIRYPVGKISYKMKRSHHVTSSHREEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4S1</accession>
    <name>A0A183I4S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ell-associated factor Eaf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14733</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041136">
        <property type="protein sequence ID" value="VDP18460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4S1"/>
    <dbReference type="STRING" id="387005.A0A183I4S1"/>
    <dbReference type="WBParaSite" id="OFLC_0001474401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001474401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001474401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001474401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26521" checksum="9EE0985E17B14CC1" modified="2016-09-07" version="1">MHRLCETIIFEHSCIRPVIPSPIARPTPKASISSASVANAAVKKEVDLWTGSEGEQRLHAVRKLSDNTVEKNTAEFTANFNTATAIRGENGQYQFSFDPSLQDNTQSLKGSSKETLVTKGDGVSPLANVGLEANDDECLKQRLDKVKDFWPGQQQFANNLLGNGNESATIAPLVTDKSGSTSVGVSSMPHGPNVAKKIYIKSVTGVRPQPQTSEQVVNNTTANLKEASSSTPFVPLLPPPSPIACLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I539</accession>
    <name>A0A183I539_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14851</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041279">
        <property type="protein sequence ID" value="VDP19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I539"/>
    <dbReference type="STRING" id="387005.A0A183I539"/>
    <dbReference type="WBParaSite" id="OFLC_0001486201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001486201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001486201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001486201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15794" checksum="CCF7DA0A2BA7DA5F" modified="2016-09-07" version="1">MGKPKGIRTARKLKTHRQAQRWNDKGYKKAHLGTRWKANPFGAASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKIVKVANTSLIALFKGKKERPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I585</accession>
    <name>A0A183I585_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14897</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041332">
        <property type="protein sequence ID" value="VDP19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I585"/>
    <dbReference type="WBParaSite" id="OFLC_0001490801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001490801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001490801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001490801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8086" checksum="1483537D7671D07A" modified="2016-09-07" version="1">MWTKRDKRLEPLFVKPSSSHMEMTNYFHFHGKYPSQILPPTPTVTTGSSFDSATSTVHWKSNSARRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5W4</accession>
    <name>A0A183I5W4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="1 6">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15126</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="1 6"/>
    <dbReference type="EMBL" id="UZAJ01041649">
        <property type="protein sequence ID" value="VDP20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5W4"/>
    <dbReference type="STRING" id="387005.A0A183I5W4"/>
    <dbReference type="WBParaSite" id="OFLC_0001513701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001513701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001513701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001513701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35270" checksum="23A5B215F47C2F9E" modified="2016-09-07" version="1">MKNIRYVSILQMMDATRIPKCLSSRCFGPTITVEIKPKQGFMQNHPGINVPFCNNCILQLEKCHSDAFEQMYDFCPLDLFSGDLKRMRKALNSLFMVPHRNLRIFLNGSLIHSDEHQLTSEQLRESLFRDGSVSVEQLISALCCILVDAPSDDLFAVHDSGVLTKLLNGQRIDTIGIVRAYQIYTSLPETTQKELLDKCLLPKKGTTFLHQNTDRALVERYLLAATMKDCSLMISMRLVDPVAFATQNVQSSGQQIVRVVGASGTDYTSFAYSVKIVDLDPKSPKNLLNAYSRFMDGVKLIEQVPNLRRPCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6D0</accession>
    <name>A0A183I6D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041896">
        <property type="protein sequence ID" value="VDP21189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6D0"/>
    <dbReference type="STRING" id="387005.A0A183I6D0"/>
    <dbReference type="WBParaSite" id="OFLC_0001530301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001530301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001530301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001530301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14705" checksum="90275DD5F110C28B" modified="2016-09-07" version="1">MSSSTNGQNNCCSINNYGGWNGDYISNSGPYTSQQMIPAPKVLKSEVGTASSAENSEAHQTNSRYIDSQCSSSSQALLQSDCIIAGETLSAAQFGPLNCRVDNSLLVLTKKFMQLQPQANEDGVSFFLSYVFCFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7W4</accession>
    <name>A0A183I7W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15827</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042970">
        <property type="protein sequence ID" value="VDP24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7W4"/>
    <dbReference type="STRING" id="387005.A0A183I7W4"/>
    <dbReference type="WBParaSite" id="OFLC_0001583901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001583901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001583901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001583901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11631" checksum="831C93D1D53DB043" modified="2016-09-07" version="1">MLAMERAIATYFSSRYEKFGKSVVVILIISQAAIAVGSCLYIYIDFKLFDSEKMVYCMAASDKDAPKVTLMLGFYAITAFISALIFPVLLCINKASYLLIFQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7Y6</accession>
    <name>A0A183I7Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15848</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043041">
        <property type="protein sequence ID" value="VDP24231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7Y6"/>
    <dbReference type="STRING" id="387005.A0A183I7Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0001586101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001586101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001586101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001586101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6237" checksum="BB62979127493403" modified="2016-09-07" version="1">MPGGARGPGIFFIMPCIDTYRKVDLRVISFEVPPQEVGKTTTFTFIELLLNFILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TWX7</accession>
    <name>A0A3P7TWX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000310">
        <property type="protein sequence ID" value="VDO27100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZY4"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="429" mass="49983" checksum="2E1AD59D979F1A4A" modified="2026-01-28" version="1">MYDKNILPSDDSIEVIVEVTVQSITEISEISSSFKADIWFSQIWHDKRLDFRHLNYCLTNLSLAAHKLPNLWTPNVCVVNSKKVTIHTSPSQNILLLIFPNGTVWLNYRVSLQGPCQLDLTNFPMDTQRCNLIFESYSYNSAEVRIVWRDWEPISIPDPSNKNLPDFILTHTENKNTSLFYTAGQWDQLEAVFIFRRLYGYYILQAYMPTYLSVFISWIAFWIDTKALPARITLGVSSLMALTFQFGNIVKNLPRVSYVKALDIWMFGCVGFIFLSLVELAIVGYIDKVNLRKRRCVRVRESSFRKHTEPWRMKSTKNDSHTNSRTPLSNMNSPVKALQQNGSFLYLNSDDRNMHDNNNSLATFWSPDYPSRRMQRESFVRRISAVEGTEKTDGEKIDEISGKTFPLLFIVFNTFYWFYYIGLCRKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U024</accession>
    <name>A0A3P7U024_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000469">
        <property type="protein sequence ID" value="VDO28220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0T4"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF100">
        <property type="entry name" value="CALUMENIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="307" mass="35930" checksum="BEAB87CE6D9338CA" modified="2026-01-28" version="1">MHVWFAFGALFVFTKAEQVDPLTDKDHFKAGGHDSRFDHEAFLGKDTAESKDVVSKERLAKLVAKMDVNSDGFLEETELKDHIDFMQKRYVNNDVDRTWKNYNAEKIKDGKISWKDYVEMVYGTVGEGQELSTEYQKMMARDEKRWKKADYDLDEMMDRTEYGCFMHPEDCDHMRDIVVQETLEDIDKNKDGYVDLDEYIGDMYRPEDYPELNGKEPEWVASEREMFKEHRDKNGDGKLDQDEMRDWIMPIGFDHADAEAKHLIGIADEDRDGKLSLKEILDHYDTFVGSQATDYGEQLNKHDPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U035</accession>
    <name>A0A3P7U035_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000390">
        <property type="protein sequence ID" value="VDO27676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7U035"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="73" mass="8501" checksum="9561A0A539E74D15" modified="2019-02-13" version="1">MWISYERKYCVFKLAFWLTNTADECLGTPGEIFIPLQSALRMRFSDDIFRQLSGVVGIFCIFHQKSASVQLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VDB9</accession>
    <name>A0A3P7VDB9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ephrin RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005779">
        <property type="protein sequence ID" value="VDO45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VDB9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ephrin RBD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="203" mass="22955" checksum="435BA711D8C71EA1" modified="2019-02-13" version="1">MLNQYFFRSQTTLNLKCIILATSTGEKNGLANGEGGLCRTKNMRLKIRVEAKWTEINQKISEFAAKNGQVMMIPMNSGQYAVPVVYVPVVPSSEVDEDDKKRLVFPYHLYFANGEFRASNSNLEDLGPRAELRFDANDQPKDFENPNFLINSDGYVAPKPLKEKDDDFEIEYMDSASKRSYEGFGIVDITIITNCIMIADTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VFX2</accession>
    <name>A0A3P7VFX2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DM10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006217">
        <property type="protein sequence ID" value="VDO46771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VFX2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="343" mass="40742" checksum="BBFA4770E40F7656" modified="2019-02-13" version="1">MNYFDYTSFQSRTFTHQRVPKLNQNCGQNYLHWSDLNVGKDIHLFSGTYRITACDHQTRDFLTRKGIEVNEEEEIPMDPWIQNQEKQQSSSKNKESEEERFEWKHEKVNYSDAPAKLHLLACWLDNTSVRTFHMIVHTIDDTVALVENTCGFRGQLFLKRNKLPFIKKDVRQFYRSSEMRPGLWVEVYTRPMFIFSCEGSETRNFLKRFGPIDFENYENVLLNGPPPELFENIPSEMKFIALMEEGKGFFEDIKFLITFHVNKEKLDITEAVKDQKWCAGRTFLSGINCSRYELALKFFIHSRSICSMDKYKIGSTLRIYRWNFRLMEADDITRQYLLSKESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VG56</accession>
    <name>A0A3P7VG56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001532">
        <property type="protein sequence ID" value="VDO33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H549"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="391" mass="44680" checksum="C67037A78EF9733A" modified="2026-01-28" version="1">MYVPVLNSEEKARELIDIIREQTDAPIGTCINTVSIILSSLLRDLPDIYSLHVIKNALEKDDIIDLDNCYDARILEQLTASITSYIEDKSQLDCSIRNDEAMMVKSLQQFSGFLKKADARIPMKHFRQDDYAFIDQLVSFYEMELRESVRIELLSTFHSLCLLDRSVITMLLGGQLSVLLVLQNNFSLPPTELDISSLQLLSVLFSTGEKFPTSHYDALNLEFLTKIVSMVGDFADAFQFVLSFNAHFGPNENIVIQALHKNPPLTFGQLLTMQLNRCRADSKDLRAIKLLMDIFCMSNDLITILFYDNDLKVLYGILCQDLIDTNQSQKMAMILQIMKNMEVIERCGFIQEVFASVKTFLLTHETQLDLRRCAESILQQVTEQINVRVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XIM3</accession>
    <name>A0A3P7XIM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000699">
        <property type="protein sequence ID" value="VDO29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1W4"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="243" mass="27614" checksum="861D32D43D2E59AA" modified="2026-01-28" version="1">MSQDGIPPKYTILLPTYNEKENLPVCVWLIEKYMRKAEFSYEVIIIDDNSPDGTMDVAEKLENEFGSDKIILKPRAGKLGLGTAYTHGLQFARGDYVILMDADLSHHPKFIPEMIKLQQNKNYDIVTGTRYAHGGGVSGWDLKRKLVSRGANFLAQFLLRPGVSDLTGSFRLYRKDVLARLIADSVSKGYVFQMEMMFRASKLNYRIGEVPILFVDRFYGESKLGSGEIIDYVKGLLYLFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z8Z7</accession>
    <name>A0A3P7Z8Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015681">
        <property type="protein sequence ID" value="VDO74133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z8Z7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="187" mass="21532" checksum="DB24F1AFEAC49F17" modified="2019-02-13" version="1">MQDRGKRLIPPIKFGPPARILVRNGRFLTHPDYPRTPHICGFADNPMSDRAVVLARRAMIRARTEISEDGMTPREKINQVLISFREDEKYADLSAEEIEQMEDMVLGRVHGRMWSESSSVRSLYINRRKLITANQNDKPRKVYECPVVDCDFLTFASGMIDIHLSEKHRITNDSNTIQSTAFEVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AD70</accession>
    <name>A0A3P8AD70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039942">
        <property type="protein sequence ID" value="VDP12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZ98"/>
    <dbReference type="OrthoDB" id="5842470at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF51">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="311" mass="35144" checksum="20465F264E1339FA" modified="2026-01-28" version="1">MTSSSNVFGEKASVFVCVVMTSIGLGLSIAAILLPSWQVVNLREYNSIHEHGLWLDCRRHSRDSNANVLLRRYTTNTEPLNCVYKFDYDKYSGTFDLEDDNSPVGEVNRHKFYGWHTATLILLALALLTSFLTICLGLSACCYSSLALIVTGVTLMTTFLSVIAEGLFFFYSHRADIRFIKGIVSTYEQRVGLAFFLQMVACACHFVAFLVSLVFVYFVWTSKSDASDRYMDSFNRGSKLNVASVGRSLEFEPQMIYQQNVAPTGIRPPHYMKHQEQYDKNVTESTPELGARQLSAEFLGQRVRRKSETCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AHK2</accession>
    <name>A0A3P8AHK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040193">
        <property type="protein sequence ID" value="VDP13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AHK2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="98" mass="10682" checksum="81837EF9E05FEF80" modified="2019-02-13" version="1">MTSFNISVTTLIALRKAAASHQVITPLRPLPIKSNSSSGAFCVALPATITKKALKRTAKRMDEAGRKARILENAITNITQRSRHRSIFHSVEQLAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXX2</accession>
    <name>A0A183GXX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS82</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000018">
        <property type="protein sequence ID" value="VDO24444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXX2"/>
    <dbReference type="STRING" id="387005.A0A183GXX2"/>
    <dbReference type="WBParaSite" id="OFLC_0000008101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000008101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000008101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO24444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000008101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42644" checksum="9D91B18075E977E2" modified="2016-09-07" version="1">MATKNSQLERVRHIHCLLCSVNKPFNGFLSHIRQKHLNYHRYKCTKCTFKSDNEEDSTLHSFEKNHLVKFDDVNYQEHLAVKIFQDCCRKQFAIRHETEKKECDNSGQTKRKGSGNSYSDIQKIHNPKKSKMKTNDVCLSSFLKDETNLQAVSENQRDYGISPNSTKCIYDEGKSESGIHNIKILSKAAASEPDDETSNALELLSDALKDTKTISPDNLPNVNTVDVVSIDGKSSGSIRNTFDHKEGIIESEKLLKATGIIILEIRIELQFPSSNWKSTEVDASYIAKKTHALQFHFTQDDDPEIAELLPATIKACFPHSLAWSDFQCTECGKTLGTYSSRRNHVLKEHFYWSTICPFSGCTSIINALDALEEHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY80</accession>
    <name>A0A183GY80_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipid scramblase CLPTM1L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cisplatin resistance-related protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleft lip and palate transmembrane protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS190</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71495"/>
            <dbReference type="ChEBI" id="CHEBI:190691"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71491"/>
            <dbReference type="ChEBI" id="CHEBI:57997"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000050">
        <property type="protein sequence ID" value="VDO24904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY80"/>
    <dbReference type="STRING" id="387005.A0A183GY80"/>
    <dbReference type="WBParaSite" id="OFLC_0000018901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000018901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000018901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO24904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000018901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="572" mass="66685" checksum="F53196CC43EA11D3" modified="2016-09-07" version="1">MFKLSLTNVVTIIFVIYIAHSLHSIYTLFHPPLCQQNQDDKECLIPMIQRDAVSAEWPPLQFRIYASVNSRAKQNYGKIIHQIAFLDIDEVMEREVHVDLPEHTRNNGSLYLHCFLLPAEHKHQDPYQASWQIIQTVRITTYQIPQAETFRLITEAEEKRRKSKEASRSVDQLREEGTPVTHFRSKLPLTIVAESLKFDLHALPGEIYQLMQFFHKEGQTYYWPIFYIDELSFLTKDLIQIEPEQKSIMMKIQYRPISIGKLRLLVTAQASLTQLKQMGFSDKDVDEVKGIFVDTNFYFLAVTIFVAALHMLFDILAFKNDITFWRNRKSMAGLSTRTVLWRSFSQSVIFIYLLDEETSLLVTIPTAIGCIIEYWKVTKSAKISIYWSKGIPYFRFGTSTAAELETESFDSEAMKYLTFLLIPLCIGGAIYSLTYIPHKSWYSWIVQCMANGVYAFGFLFMLPQLFVNYRMKSVAHLPWRTFMYKAFNTFIDDMFAFIITMPTSHRVACFRDDIVFLIYLYQRYLYPVDKSRINEFGESFQDTEIQDVRETESPSTLASFAQSKSKASKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYL2</accession>
    <name>A0A183GYL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS322</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000097">
        <property type="protein sequence ID" value="VDO25391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYL2"/>
    <dbReference type="STRING" id="387005.A0A183GYL2"/>
    <dbReference type="WBParaSite" id="OFLC_0000032101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000032101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000032101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000032101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="16011" checksum="1D9538A0723F2B16" modified="2016-09-07" version="1">MQKHEFGHFDELQQKQWIFAMNLAIERKSMEDLRKHDRECSRTTECRVLRDKNLCWRLALECENERLTQLLNDQRKALRDEEIVRTLAARMLDEERERREKLEEKLQDLIKNLSENCNSNSGTTEGSLQGWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYM5</accession>
    <name>A0A183GYM5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS335</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01000103">
        <property type="protein sequence ID" value="VDO25448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYM5"/>
    <dbReference type="STRING" id="387005.A0A183GYM5"/>
    <dbReference type="WBParaSite" id="OFLC_0000033401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000033401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000033401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990698">
        <property type="term" value="F:palmitoleoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO25448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000033401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40796" checksum="6D9D686CF237BB29" modified="2016-09-07" version="1">MSDEEKWFYDESLELSDEEFIDLIYFKEEITHQWQLCPIGVLGSLRSTILKLLLCSALKRFLVFLHAKGIISDFTLHLIFIASGLFIIGTQNNLLLSICTYIALTVILPYYKFLFNKQTKFVILVYSIGMLLIWQYFFTAKEFMSMRGILMIVLMKITSLSFDLANEFDGRITLLHLLSYMFDSSTVLFGPWITYKQYQDSLCLKEFKVEITNCFRALSYIALSLLAVIYSSCIADNFIEWPFIGAYFVAQSFRFSHYFVSWLSAGTSLLSGIDSGIVADWIHIELPRSLVDVVVSWNIPMHRFLHHHIFGEIKKYGSIPAIFITYAVSSLFHGINFQLSAVLLSLGFYTYAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZN1</accession>
    <name>A0A183GZN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000253">
        <property type="protein sequence ID" value="VDO26719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZN1"/>
    <dbReference type="STRING" id="387005.A0A183GZN1"/>
    <dbReference type="WBParaSite" id="OFLC_0000069001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000069001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000069001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000069001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11629" checksum="1F27A071DD09DFE5" modified="2016-09-07" version="1">MVPNAVSLDLSSNRLTRIHGEWPFLLEDLNLSNNPSMERFPSLSLIPQLSVLNMDNCGLTLLPLSTSSNLRHLSLQYNRLTFVDFDSLNLPSLQKVCLILFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0A3</accession>
    <name>A0A183H0A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS913</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000372">
        <property type="protein sequence ID" value="VDO27549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0A3"/>
    <dbReference type="STRING" id="387005.A0A183H0A3"/>
    <dbReference type="WBParaSite" id="OFLC_0000091201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000091201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000091201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF40">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552323" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="747"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="953"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO27549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000091201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138373" checksum="414DB39E6BC17722" modified="2016-09-07" version="1">MVLLQILTLSVALILSDATAVPGHNLPFDHAHQNYTDNQRTLRINRNEEDQKKSDNDLRNKTINNVHIHIFLIAPNKAPTNSKMQISDLHNQEIGEETFFTSLINHKCYFSSIPRYLYFCCFLNNRNNIPILGSQQNPISLKIDLGKGTVNEVSNSLSRINDEGAIFVNDGLDEAALTQNFLKTFNSLLRDDFSHIGNDNSKNYAIDLQNTTVRNAKESLITATGKPIPIGLIDLEKGSTMISTLLTDRSNGNNEDEVQYNKPEKRLLEKAEPSTRYKPNADIFELEDKIWSNTNFDETNAALPNIMEEKTPRRSSNLNLNPTGRRFGKLASSHILDYSEFLTRSPSVETGAIVPDFGAILNSSEQIPSTATISIGGKETQSSGATINFGSYASDKGIFSTTSRVAISKNILPDESLVTSTVSLPKDMAELVIFPNKQNFDTTLVGMKLSPTSDDTSRPSEQKVMMVNFGTASTENTTIPKINSENRDFGSANPAAFITVGDREILEEQKPQMKVSSFFSVPRIVVGEKISDLQETHPSESVEDEAAIIERQATIPSMQKQNIKIIKNTSPYQVPETESTEVPQQTQFKEPFQPRFSSRNGVKLTDLVAQGTKIAHPDIFFIPEQDFATSESDYEELIDSLRTSLSNTDTLFIESERDERESEVLKSESITSSSIPIPESTKYTQFTQPHLSLNPITLEAMNDKVSIISGSNTNELKTIKPIYCDISAVDGDECPIANDKSDQAQCDVLFLIDASRNISKIHFQRAVKIVMDTVEQFRNIGPDGIQISLVQFTREPVLEFSFRKHNCKPCLLADIGNTEYIGGLNNADNAIHKVVKYGFSKRRGDRNEVANVLIIINSGISDDRFQETLQLLNPNSTTVIVLSTEDTNSQLIKQLIKDERHQNFFFNVTAVEKDQLANHLAERVRTIAEEKSTYFEKPITMITDESVRKFTVHCLNNGFNVTFTLLKSFGGTIAVQGKNATKSCSRIIQAEQFGENIETREVNLFISFEQCDVKETASMNCEINLNSQVNPAGMNYSTLINVIHDKWLVTGADKGFVAHCYQAQQSQEQNLVTDLDLQGFSEIKIAEILPLNSVPPLCNYSIRADAPNGPLVQSAKLGETVYHRWECENGRHIGEALDLYGLHIHDCYAESEIEQQHIIIDSKGCSADTNIVSDVVYADDKLLAFSHVKVFKLINSEHLSFHCKLSLCIRKADGCEGITPESPDNSVKLKRLFCYDTCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0R0</accession>
    <name>A0A183H0R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000459">
        <property type="protein sequence ID" value="VDO28117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0R0"/>
    <dbReference type="STRING" id="387005.A0A183H0R0"/>
    <dbReference type="WBParaSite" id="OFLC_0000106901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000106901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000106901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000106901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20165" checksum="2E3EFF4ADA8FD1DB" modified="2016-09-07" version="1">MSLLERAEDIVLPVCEQSADSASIAITASPWKVTATQEKTVARNMPESPDMKFARTRFGHLLDGIRSGEIQTGMQARNRARSPEEMERDLLERPKKSLRRESRRMVFELRGKPFALRDSGRREGVYALCRNWMRGSDDERPKERREIEHPEPSDDSLVGPIFCEKLIFFVPTFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0R7</accession>
    <name>A0A183H0R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPI inositol-deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1077</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000461">
        <property type="protein sequence ID" value="VDO28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0R7"/>
    <dbReference type="STRING" id="387005.A0A183H0R7"/>
    <dbReference type="WBParaSite" id="OFLC_0000107601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000107601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000107601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000107601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61675" checksum="BE9427AA1ACEAADB" modified="2016-09-07" version="1">MFSRELFFLRSLFTAIKCRRDGKIQNSFQAVTMLNQNKNTKAAMEYLERLDADVELCILNTQTRFRLALRGSLLCKRIATTSTEKSIKSLGMLENAIKRVRSSYCSTACHERLFCNSVKSCEEFQLVIDDEWKETVKWLIPHMHDEDDPSSYKYFLKRRRSQDLRLNRFLSQLVLKTETGFGRELIIQDILTLLMELCNHYRETNRNIYLNALKILANIVGQNEYCATAVANSEWLPMLSSMTMSHIFEEVLMAEKICNNGLSVFDSSRKLLKSNIYELFRPDDDQQPVIDLVLIHGIRGSVFWTWRERDSPSKILRIRCWPRTWLPQDVPVPLRILAIDYLSSLVHFVGVIETVNTRAQKFSMELKTAGVGDRPILFICHSMGGLLVKRILLDDPEIRRSTVGILFMGTPHRGSPYAMYAPLGVRPSDDVKLLHQQSTINRQVRSCFYRVPRPSLYQKLSGKLILKLLGRLLHQDFLKIIDTIPVISSVAETKKAPLIMRRKGILVPPESAYLERGAFYHINDVYPFPSFNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Y3</accession>
    <name>A0A183H1Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1493</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000712">
        <property type="protein sequence ID" value="VDO29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Y3"/>
    <dbReference type="STRING" id="387005.A0A183H1Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000149201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000149201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000149201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000149201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39341" checksum="C169BB9458531E2C" modified="2016-09-07" version="1">MEENGMKGKLEVELIRDENPVESLTKNNSTDDLISLTLPTQTRSNKRKHIRTDFDEIKVSSDAAEAQRRERERLERLSKIYESEVGNLVGTEYKEELNTDGHAYMKLEPVSKCLKTSSLTDVKPSTSFTNNDIIELSSDEDSDVDCHPLGLIQPLPLRRRSPLYRVLHEDVTDELHRVERERLCKKLFTEEELESKKLMGGRLLVNPGKASDEPDVYVPFHLSDVLQPHQLGGIRFMYGNIIESVRDYGKSPGFGCILAHAMGLGKTIQIIAFTDIFVRTTNAKKMLIIVPVNTIQNWYSEFEKWLPDRVTEAGENIRPFIVWLLGDAVKTNEQRAELIPISNQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2R8</accession>
    <name>A0A183H2R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1778</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000903">
        <property type="protein sequence ID" value="VDO30750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2R8"/>
    <dbReference type="STRING" id="387005.A0A183H2R8"/>
    <dbReference type="WBParaSite" id="OFLC_0000177701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000177701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000177701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000177701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7566" checksum="14C4143C888F737D" modified="2016-09-07" version="1">MENIDAGEESARILREEVKALASEIRTLKSVEGNEDLTERKVTCMIEQKPLANHESQKKLEIRCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2V5</accession>
    <name>A0A183H2V5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1815</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000928">
        <property type="protein sequence ID" value="VDO30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2V5"/>
    <dbReference type="STRING" id="387005.A0A183H2V5"/>
    <dbReference type="WBParaSite" id="OFLC_0000181401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000181401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000181401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000181401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35320" checksum="C47A4BCC5C957E94" modified="2016-09-07" version="1">MQKLSSHKIAVDTLTYIRKIVGLGKYNSAKDLIDLLEIERKHLLEALPYQFVVSNIILCVIKMICEENGQTIAAFGDLVPHDSLNELWKTPDSKKVMDSRELRKSTIVAINEFATEVDTCIEDICAQVQAGNHICTSDVIITHSLSLSSTLRAFFKSARKSQKSFRLLVVDEEVDYGDCLSSVDILTAMQRATRVFISAVAVFPDGSCLAPAGCLMMCLAAKRHAVPVCVCTSFYKFTPFFVADIDRIHTFGCAGDVVPFTEMEEMEDVQVVNPVFDLISAELILQYISHTSTFTPSHVCRFIGDYYCRDRIEMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H367</accession>
    <name>A0A183H367_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HDAC_interact domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1927</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001021">
        <property type="protein sequence ID" value="VDO31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H367"/>
    <dbReference type="STRING" id="387005.A0A183H367"/>
    <dbReference type="WBParaSite" id="OFLC_0000192601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000192601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000192601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="6">
        <location>
            <begin position="497"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000192601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="792" mass="90590" checksum="54F8307076DA641D" modified="2016-09-07" version="1">MSAINGGSNPAIRMPIVNNVILNDTLQSQRENIVPNGNASFQSNQVSEAPRESDMRGNVRRLRVEDALCYLDQVKQQFTDTPDVYVNFLDVMKDFKSQVIDTPGVIKRVSRLFRGRPNLITAFNTFLPPGFDVSVDGIKVIITEPNGRRQVINENQPEFSISESQAAKSSSPIQPLVGVTGDLLSATSEASVSDSVPAAEPIMTEQSGDSQSNEVRPIDFLADRISTATYQDAVMYRNKIMARFEERPEMYHKFLEILQRLHRVTQEGGVIQGYKRALEAVEILFENDADLVQEFKQQFQPNSFGSGISCPSSSTPRDTIGKGKIQKSGERGAFVVSPQPVCVPKVQNLQGMSPGKRTASIYSTVATKRAKLGSINMLTYDTDVEEAAKFGTVEDYLFFDKVCWLREVRKALIDNGVHENFLRCLALYNQSIISKNELVELLTPFIGRFTLLLKHVKELLGLPDTHSDSQQNDDKHRRRQVHANDDMELEHKIDYATCRRLGVSYRSLPESYEKPLCSGRTPLCDSVLNDSWVSFPCWSSEDSSAVHSKKTPFEEFVFRTEDERYELDIVIEVNKTALEVLEMVQRKMLRMKNEELNSFRLGPSLGGSSNSIMFRALQRIYGDHTLKMLEGAMKNPQVMIPRLIERMRQKDVEWRKNQEICNRIWREETEKHYAKSLDHQAIIFKQNDLKLLRAKTIVSQFENLYDERADRNDEGESVEYGPHCIYSYPEDIRVLYDVNDLVIHYVKRQANIQKEEKRLAKRYLKRFIPELFNVPPQELSDEEETEDRDYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3S2</accession>
    <name>A0A183H3S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-Hacid_dh_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2132</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001166">
        <property type="protein sequence ID" value="VDO31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3S2"/>
    <dbReference type="STRING" id="387005.A0A183H3S2"/>
    <dbReference type="WBParaSite" id="OFLC_0000213101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000213101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000213101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="413"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000213101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="807" mass="86430" checksum="E43DAC2E9F53C507" modified="2016-09-07" version="1">MHEAVTTADQRPPSMVFTAAELPKFTTHPATFIPTVFGGHVLVYESRSHPGHRREFAFKTRFTNQSGVSSCYYRCMSCRSMKNKVPPGPDGKPPQIPCIAVKNGFIVNDPDFPEANDHFCVPPTIDESRQREANGFAKAIVKGRPRQKTTRKNNNNGNIGVIGNGSNAKKDSIIAAQLQAYQEMSNALLNGSVGNIFDISSIAGGFDLSSDFSASSASQLLSLVTGGVKGELDSAGDSSDFLKNIKIEDDDSDGTAKATHLLASLISSEPALRTQMMLPTTAHRSNILSLPVATSTVATSSGSTEDEQLNGMNGPDIRSSPESSTAVIINSLQGSDSRPPSVSSSSASLPLSGITVPTVLANGLSANSRKRKGNGGNSLEAHFDEIFERYILNNWEIVDNGKKPENIAEHTCALILALARKIPQAVIAIKEGKWTRTEPYPEELFGKSLAIIGLGRIGLEIAIRMQVFGMRTFGYDPQVTQEEAARHGIRWLPLDQLWPQADYIVIHVPLIPRTKNLMCASTLARCRKGVKIINMGKAGIINEVDMLQALNKGRVGGAAFDIYVEDAPVVRGLIEHPNVLCTPHTGTSPLQGHQRIANEIAENIISLNNSTGPYGAMNAAAATAALDEAKSQWIRAVATLTQTLAVIGNSPKAVTIRFPNSLVSLQKALHAGAVVGLMYANGNIGSNLATAEINARKEGVQIREEPCAAKELIVVAGTRSVSGYPAPTGTVISAFNSCKVPVPLLASGTFIMDFADSHSFDIIDEDIKTKMMVEFSLLGGGRVGVLNDLTTDDVLELSKNYCLVKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3U2</accession>
    <name>A0A183H3U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001179">
        <property type="protein sequence ID" value="VDO32038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3U2"/>
    <dbReference type="STRING" id="387005.A0A183H3U2"/>
    <dbReference type="WBParaSite" id="OFLC_0000215101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000215101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000215101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000215101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8317" checksum="F4558BBAE337F96A" modified="2016-09-07" version="1">MPGGQLLQPPGDSDTDSGICADSDNQLSPRHIIGVGFLDNKLTKQQRKVQASVYRKHSAPENAWYDLLMCKYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4R3</accession>
    <name>A0A183H4R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TIP41-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2473</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001427">
        <property type="protein sequence ID" value="VDO33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4R3"/>
    <dbReference type="STRING" id="387005.A0A183H4R3"/>
    <dbReference type="WBParaSite" id="OFLC_0000247201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000247201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000247201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000247201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29375" checksum="BBB4D868069D9FF1" modified="2016-09-07" version="1">MSTTSLHIGNLQIDFTKRLLLIDRFDYHSSDIAVAATTSSGLHPAIIEQQCKRTLTVNIGCAIIDQNMQIKEYIVDDNLLTIKTEEGIELIIKYDTSEELYEKYEIEWTSSKNYHYMKDVIQADANSQWYGGPQVAQQTWPLAETTQNFSPYLPSDTLKTDTVAPTLSYSIFVAKRCMLREFHVVLHGNLYDLCTTIPDEALIRKPIWSTWARYLEKVTQYDVLEFAQEILNNHAPICQLELDDNWATQYGDFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6A1</accession>
    <name>A0A183H6A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001888">
        <property type="protein sequence ID" value="VDO34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6A1"/>
    <dbReference type="STRING" id="387005.A0A183H6A1"/>
    <dbReference type="WBParaSite" id="OFLC_0000301101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000301101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000301101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000301101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14560" checksum="2E497EB3DF0ED63D" modified="2016-09-07" version="1">MDFYITSNASCGEVIEKLLTEKLSCIAVVNECNMLLGKISKKDIMHELVEHSNNYLEIINVPVKNVYRVPPFGLPTHTVYEVIALLLSSNDQCLFIVDCNQRIVATVAFIDIMDYILNSSEIHREINVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6G4</accession>
    <name>A0A183H6G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-RVT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001941">
        <property type="protein sequence ID" value="VDO35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6G4"/>
    <dbReference type="STRING" id="387005.A0A183H6G4"/>
    <dbReference type="WBParaSite" id="OFLC_0000307401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000307401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000307401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000307401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16568" checksum="C4A30A6569366056" modified="2016-09-07" version="1">MEQFKKSLNSKTGRSTIRSAGRKWKCSTIKHSAKECPNVSDQLQEFNVRWEACIKKSMLLTLEEHRRSLGEPELTPEQRKLLWAYGEPRDMKEWVLIFSLTDKLQVSHKCNVANIAIHTWKKKKWLTLAGTYLWPRKKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H701</accession>
    <name>A0A183H701_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3263</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002128">
        <property type="protein sequence ID" value="VDO35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H701"/>
    <dbReference type="STRING" id="387005.A0A183H701"/>
    <dbReference type="WBParaSite" id="OFLC_0000326201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000326201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000326201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000326201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64114" checksum="2F5E525AAED39279" modified="2016-09-07" version="1">PSSSDTAAVLTDQNVLPVSSSPHTEPTTTTFPASQFDPVIVSSEFGSTMKMELKPGLEEKDVLETTAINLPLEPSMMPPIASNLLQDSIHSHAMSPPGTENIPHDEQKAQRNPIAEMNTERESVDKPVQTKDEVKTDIIEEDGLGYCIKGECDKVYNDAVVDEKTETGYLFVIGRLLSKLIGIARYILPLSMSNFDDAGVLVTFFVPICLLIHLLRVLVFADTCDKDNFDRRILHNALTTIRQREIQIKLLQTEIEKGKNSWNTEMDEKFENLQSEMNQLKARYYTLEEENDKLKAEADETSQMIEREHLKCRDLMEQNKNLEEKNELLKKQSSEIRATVEVLQKENERLVNEVARKSAQLTRLESEANSHSLEIKNLKDQLKTSLTENKILNQRVEELQNETVQLSEMINKIHDSNNVIVHERSSVAEAENDEQMQQNINGESGWSDFDEFDVDSPTTEISDRSKKDHVTAIRFSPAEIMEIAKLRVKLKSVEADLDQTKLIVQKQLDERDHLMRKVEFAEAEAVKRLKEVEAKEAERIEAQNQFKRILGMVEERVNFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7H1</accession>
    <name>A0A183H7H1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3433</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01002287">
        <property type="protein sequence ID" value="VDO36475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7H1"/>
    <dbReference type="STRING" id="387005.A0A183H7H1"/>
    <dbReference type="WBParaSite" id="OFLC_0000343201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000343201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000343201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO36475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000343201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21702" checksum="1BBE85F5A8A2DCE8" modified="2016-09-07" version="1">MACIAMFDFKQCDPKRCTGKKLERYGFVKVLKLGTKFPGLLLSPNGERTISPADLSYILSGGLAVVDCSWNQVENVHLNRAKASHYRLLPYLVAANPVNFGKPCQLSCVEALAASLYMIGLKSNAHLLLSKFKWGPNFLKMNKDLLDAYAACKNGPEVIARQNAYLQELAKEANEMKQRPIDMPESDSATDNDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7L9</accession>
    <name>A0A183H7L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3481</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002331">
        <property type="protein sequence ID" value="VDO36654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7L9"/>
    <dbReference type="WBParaSite" id="OFLC_0000348001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000348001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000348001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000348001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4949" checksum="81ECC7E0AF357D80" modified="2016-09-07" version="1">MLMRSTNTRKKYCDAGKKSSIFQTRGQITWKTMQYMLKQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H822</accession>
    <name>A0A183H822_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3634</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002503">
        <property type="protein sequence ID" value="VDO37239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H822"/>
    <dbReference type="STRING" id="387005.A0A183H822"/>
    <dbReference type="WBParaSite" id="OFLC_0000363301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000363301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000363301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO37239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000363301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51796" checksum="FB9BAB7A277CC5AF" modified="2016-09-07" version="1">MFNRCCCSVRLGISRQRITFPYILRYCDISNDDNASSEAENLQGSKFVKIVSEIRKESKNTTPEAITNENLKPEDIQKKLLELKRKKERKKPKANEVASEEILTAVDSVVKNLHCSGLSDERKTKNELIEKLMEHEKEKFEAATSAQYSELLSDKVFATFLESLKDETIKPPPRAVEKRRMRQGLLLLKREIFYQALQSGHKAEDARKIAERAVTIAEQRAVGKHEMLVQNYTEEQKKNLLKEIEQTEKESAFYNIALQLASKMLYPDDPSSDEPHIVPSNVIHPDCRVENIFENTENKLNIFKRTDIPKLKDHSMKLWYEWDKNAAMIWNQSFGPANAFEEMIELTEQGKMWPYPIDNEYQIGEEENVGFYDHIFLDKYLAQYNLPEEGPVAQFMELVCVGLSKNPYMSVKKKHAHLDWFANYFKEKAEEIKRIQESAGVIAEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H874</accession>
    <name>A0A183H874_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3685</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002554">
        <property type="protein sequence ID" value="VDO37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H874"/>
    <dbReference type="STRING" id="387005.A0A183H874"/>
    <dbReference type="WBParaSite" id="OFLC_0000368501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000368501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000368501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000085">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000368501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45005" checksum="3494901114ADEE96" modified="2016-09-07" version="1">MKAIRALKWSHNDQWLVSADHDGFVKYWQPNMNNVHMYQAHKDEAIRSISFAPTDVKLVTGSDDATARIWDFARCVEERVLRGHGSDVRSVDWHPQKGLICTGSRDSQQPVKLWDPKTGQCLSTLHDHKNSVMAVQWNKNGNWLLTGSRDHLIKIYDIRMMREMHTYRGHKKEVTALAWHPVHEGMFVSGGGDGSLAYWLVNSDKELGFLEHAHDQAIWTLEWHPLGHILASGSNDNNTKFWARNRPGDTQDDIYGLASFSGSISTPAKETKTETAEEKALAAVIPGMGLDDDVFQGMQKKDALTTVGGPPVGGPLLFPEDPNARQQTMNIGAKRTLIKQPPPKKAQRQFERMWNVAKPGVSGSGDYTDEIPEEGTFRRSKASLLGPPPRSLLSSKREEGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8F6</accession>
    <name>A0A183H8F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3766</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002625">
        <property type="protein sequence ID" value="VDO37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8F6"/>
    <dbReference type="STRING" id="387005.A0A183H8F6"/>
    <dbReference type="WBParaSite" id="OFLC_0000376701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000376701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000376701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="293"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000376701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44285" checksum="707DD2A52DB155C5" modified="2016-09-07" version="1">MLTDIYALSTIFSKKLILHIQVFTDLALDLLGSESTVSVSPVLGHVPPEEKLIEGGELRLSCIAVLGTPKPVLRWYKDGKPLQSSAHIELRGSMLMLRKGRSQDEGRYTCIATNPAGNASLNVNVELIRKPRIEKNDVLEYTASTGEVLEIPCHTTGKPQPKVIWSFDGKPISSSGQEYEILPDNTLRIYQTSNAHSGKYVCTASNLAGEAKIASNVVILSPPVIEPGQISYNLVQGNPIKLPCEVRNGYVDEDGSLIIESVHELHRGQFKCVATNNVGKDEKLITLTVHTVPIIEGSDQLKVVTTNVNQSVLLPCPARAFPPPSRTWNYEGNRIYDGYSHGSKIKQTHDGSLEIATPQMNHAGRYICHVSNLAGEDHMTYLLRIQESPKIISDIPGWKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8L0</accession>
    <name>A0A183H8L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3823</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002689">
        <property type="protein sequence ID" value="VDO37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8L0"/>
    <dbReference type="WBParaSite" id="OFLC_0000382101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000382101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000382101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000382101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10497" checksum="147B1AAB93DEDBC3" modified="2016-09-07" version="1">MERKIFNKLARRERERENEWVLWTTSNDVILEKASRVDVTGHGATISDEVVSLGGQSCYSLFDAKSRAVDPLNKRLRGRMCPVAHELCMNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H944</accession>
    <name>A0A183H944_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reduced folate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4013</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002891">
        <property type="protein sequence ID" value="VDO38584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H944"/>
    <dbReference type="WBParaSite" id="OFLC_0000400501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000400501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000400501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF20">
        <property type="entry name" value="FOLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000400501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41345" checksum="8635B5AD65968CA7" modified="2016-09-07" version="1">MYWKHIAYLMCLFGLIKKFRPATPFITPFLISSYKNFTDVQLYSQIYPLWTYSYLIAMVNLYFQIPIFFLTDILRHKPIVVLEALSYCISHIIILWGNEVWQMQLMEIIFGISTASDIAYVSYMYAIVDQKYFKRITSYVRAATLFGKFLAYGSGQLLISTHLISFGSGCITLLMACLLPTISSKIVQNKNLQEVENCDQIIEISGDERVSLNAISPTVVPGMKSYFRDAWTHMMIFKSKTNVFKWYIWWAFAGCGTFQVQNYVQNLWALLQQNDKAYNGITECTATLIGAIACFFVQYLKVDWAKCGELVLWVNSIISAILLIIMSQTTSAFMAYILYIAFAIIYQLLMTAARFTIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAA9</accession>
    <name>A0A183HAA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS4421</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003346">
        <property type="protein sequence ID" value="VDO39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAA9"/>
    <dbReference type="STRING" id="387005.A0A183HAA9"/>
    <dbReference type="WBParaSite" id="OFLC_0000442001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000442001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000442001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000058">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF8">
        <property type="entry name" value="ASPARTIC PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000442001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33970" checksum="74B11A9BDAB500B9" modified="2016-09-07" version="1">SSDLWVISTECNSQSCRGNELHPKNRFDPTLKSSTYTEIGRSFSIAYASGYAAGVLGSDVVSFDGFTIPKQIFGVAKRISYVFGDIPIDGIMGLGWPAISSFHATTTMQNILDVMDEPIMTVYMTRQMEPITEVVYGGQITFGAFDRENCDNWIDWVQLTSQSFWQFTITGLQVSSFMSNNWLQGISDTGTSFLVVPSFLMKPITKNINATFSFQYGTYIIDCSMQKTGPDIEIGIGGMPFVIPSNQYVLKYTDENENAICIFGAFENFGVGFGPSWILGDIFIRSYCNVYDFANNRIGFAEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAH4</accession>
    <name>A0A183HAH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4486</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003422">
        <property type="protein sequence ID" value="VDO40132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAH4"/>
    <dbReference type="STRING" id="387005.A0A183HAH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000448501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000448501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000448501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO40132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000448501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22208" checksum="CA8C83F4CF34703B" modified="2016-09-07" version="1">MQENYVFENPAARYSMESLRVGWESLLTSINRTINECENQILMCNSKGISEEQLNEYRSSFNHFDKDRQGLDSEQLKSCLISIGYNIRPGKEGDQDMSRILSVLDPNRMGRVSFNAFLDFMTRETGDADTTEQMIESFRILAGGKPYITAEEIRRELHADEAEYCIQRMQKFQASNGPPGSYNYVSFSKSLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAI5</accession>
    <name>A0A183HAI5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4497</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNRIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003437">
        <property type="protein sequence ID" value="VDO40161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAI5"/>
    <dbReference type="STRING" id="387005.A0A183HAI5"/>
    <dbReference type="WBParaSite" id="OFLC_0000449601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000449601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000449601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031718">
        <property type="term" value="F:type 1 cannabinoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952:SF1">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO40161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000449601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20623" checksum="D53C70BA00D1D7AE" modified="2016-09-07" version="1">MPEETDAKKSRIGNSPSSSTNGFELQFNIRKYDTGEPITFKVDGGRFGKTQEREVKSDVLLRTYKFRSEVIYKIILTTKPATEFHVLHISGSDLELRPESIGGGVYSAEWNTTGSDVTLNRKREYITISLQGPGRILQRKLQVKFYRNDNNHADYGDKLEALIWKCSVDNMGNIAVVDETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAY6</accession>
    <name>A0A183HAY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4648</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003635">
        <property type="protein sequence ID" value="VDO40618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAY6"/>
    <dbReference type="STRING" id="387005.A0A183HAY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000464701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000464701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000464701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005863">
        <property type="term" value="C:striated muscle myosin thick filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000464701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="47303" checksum="59636B66A8E7B475" modified="2016-09-07" version="1">MQGELEHQLLQANPILEAFGNSKTVKNDNSSRFGKFIRINFDMSGYISGANIEFYLLEKSRTLRQAGDERSFHIFYQFLRGTSAAEKGNFLLEDVDKYRFLNNGYINLPNVDDANEFHNTVRSMKIMGFQEEEITSVLRLVSAVLLFGNMEFFQEKKSDQAILPDDRVSQKLCHLLGLPLVDFTKAFLRPRIKVGREFVHKAQNKEQAEFAVEAISKACYEKMFRWLVGRLNKSLDRTRRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNNTMFILEQEEYQREGIDWKFIDFGLDLQPTIDLIEKPMGILALLDEQCLFPKATDKSLVEKLFVNHSKHPKFVIPEMRAKSDFAVIHYAGRVDYLADQWLMKNMDPLNENVVALFQNSSDSFVVNIWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBD0</accession>
    <name>A0A183HBD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4792</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003824">
        <property type="protein sequence ID" value="VDO41067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBD0"/>
    <dbReference type="WBParaSite" id="OFLC_0000479101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000479101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000479101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000479101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8872" checksum="7AB9C93729277A25" modified="2016-09-07" version="1">MVDETLDKHDSTAFAKRAKFAFAKRYPSRFAFTKQYDDEDLYNYMKKAMHFDYPTRFMRNFAFAKRDPYLSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDG9</accession>
    <name>A0A183HDG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal cation transporter, ZIP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5531</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004806">
        <property type="protein sequence ID" value="VDO43456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDG9"/>
    <dbReference type="STRING" id="387005.A0A183HDG9"/>
    <dbReference type="WBParaSite" id="OFLC_0000553001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000553001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000553001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO43456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000553001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32420" checksum="C206883057C035F4" modified="2016-09-07" version="1">CNYNLQFAFLLRRVANTTTGFWPLLSVFSVFGGGVFLATCLLDLLPDARESLRKLEEMQQITYHYPVMEIFVAVGFLLVLSTEQVTMFIREMEWHSSADMDHLITGYHNRDESNPELTGFHSEYESQINQQSLTQSQSKIRVILLVMALSLHAVFEGLSLGLVGGMNEIMQIFFALLLHKTVIGFSLGVRLVQSALSPTVAFIWSTVFAAQILVGGFGGIAILDFVSRGSPLIAGKVSFIAQAVACGTFLYITCFEILPREFHQHQLRIAKLFSLVTGFTLIAVLIALFPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE82</accession>
    <name>A0A183HE82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5793</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005172">
        <property type="protein sequence ID" value="VDO44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE82"/>
    <dbReference type="STRING" id="387005.A0A183HE82"/>
    <dbReference type="WBParaSite" id="OFLC_0000579301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000579301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000579301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="8">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="167"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000579301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43234" checksum="E2CB71353E2D1DCC" modified="2016-09-07" version="1">MKCAWRPMVSMTRLQQKLYASTISSEGIVSHDRLRLFVRAGNGGQGLQRYNGTGGDGGDVIMVGHSKMTFEAMLKNAKHRVLKVQAQSGANSSQTSLIGINGKSKILKVPVGVDVINAETKLLIARCSRPFFNYVIARGGRGGCAENCFQATTGERFFVDLHLKLHPNIGLVGFPNAGKSTVMKALVPKKNIKIASYPFTTVKPQIGYINQFGSESESTDDDDGSFSLSIADLPGLIEGASLNRGRGREFLKHLEFSDILLMVIDVLGFKLDLSLSNPYRSALETVALLNIELEKYDPALVMKPTIIALNKIDLPNGEQKAKELISILEKKNWSEMLPEEMRPTKPISIKTIIPIAAKYRRLGNLKKELKFLYERINPLLAPDFGSAKKTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEF9</accession>
    <name>A0A183HEF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransf_25 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5871</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005286">
        <property type="protein sequence ID" value="VDO44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEF9"/>
    <dbReference type="STRING" id="387005.A0A183HEF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000587001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000587001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000587001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000587001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27514" checksum="BD7313D760C3F844" modified="2016-09-07" version="1">MIMSSFSTEDRFLFPFKLFTYFRQRYAPELYKEFHFEDMPLSVFRAALKKQYTNNAHLTDFRVIDRKIAECRQMFAELGKSACCTYKFHCIFLESAKRRFCTNSKSLQSQQTSVDGSDVKTFAKLSPDWTKEDGPFKALYSMNRLRLPLIVDTIGRKTEQGHDPLLGLHIADIGCGGGILTFPLARLGAYVEAVDASADVIASVKEAENCFRHENHESGKATFKCSSVEDFASNNAGSKVHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEP0</accession>
    <name>A0A183HEP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5953</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005396">
        <property type="protein sequence ID" value="VDO44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEP0"/>
    <dbReference type="STRING" id="387005.A0A183HEP0"/>
    <dbReference type="WBParaSite" id="OFLC_0000595101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000595101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000595101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000595101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22264" checksum="623F5BC18577852E" modified="2016-09-07" version="1">SEEVGENIDEAVASDASPSYRSSRRISLRRKSILSDQELAIERKQSEIYRKMSQISFLPSVSEVVTVVRHPSVNMSKQSILIMLARLITIHVPLWLGVIAVHITIIELFDNHIFYYHNPRMKLLSMIIAVLLGLFHEVKWTWIVNDIFGIATSYVVIARTEVSSNNLEKKKSLIRYKGFIKVVMSCQGESANVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEZ5</accession>
    <name>A0A183HEZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6057</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005543">
        <property type="protein sequence ID" value="VDO45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEZ5"/>
    <dbReference type="STRING" id="387005.A0A183HEZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000605601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000605601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000605601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000605601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31279" checksum="E1210E46801C2178" modified="2016-09-07" version="1">MNGLEGARVALLACGCYNPPTIMHLRMFESARDFLEVRYGCEVVEGILSPVADYFGKPDLLPAAHRQIFFLLLLITILLIEICNFFLIQKRNCLLWGYHISYKMSELAVKSSTWIRADKWECTQQQWTRTLLVLVHFKKMLDRKYNDSRLRLMLLCGGDVVDSFKRMTSSGDYLWDPSDIAAILRDFGLVILARQNSEPMKTLNQLGYNGQSLANVFVFEDTALPNDISSTRLRAAIRRGESIKYCTMDSVVDYIRKYQLYRIKNNQAANCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFM2</accession>
    <name>A0A183HFM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6281</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005877">
        <property type="protein sequence ID" value="VDO46015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000628301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000628301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000628301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000628301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7815" checksum="B7B4FC92FABA0F7B" modified="2016-09-07" version="1">MKCSNRVNREKQDYQFDDRIRLPVERAIAQIRKKQEAIKDDIDNVDNIDTEEDDESIDQLSGLDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFM5</accession>
    <name>A0A183HFM5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6287</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01005886">
        <property type="protein sequence ID" value="VDO46034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFM5"/>
    <dbReference type="STRING" id="387005.A0A183HFM5"/>
    <dbReference type="WBParaSite" id="OFLC_0000628601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000628601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000628601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="72"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO46034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000628601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30647" checksum="0FD2AEEF65C2D282" modified="2016-09-07" version="1">MSRSTLAKLSKCLYFHKAISSTAVSAKRFSSAPDFDSLAQKVQQWKEKRTTDNSTDDDEISFGDKIIEKREWMNAPLVYCDGSFDWTMRKGGIGIFWGPNDERNAQLSLTGSKLTNIRAEIQAVSLAALQNLLLFKACSLDFERIIIKTDSQFVVKVINSWLSKWRSNEWKKVDGKQIENMGDIQKLSRYTEMIKMRVEHTYGHQKYDESKGLEENWDEMSNDERDRCGNFYSDRLSRLAINEPMMTDEEFEKLCQTKLDKHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFZ6</accession>
    <name>A0A183HFZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6408</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006071">
        <property type="protein sequence ID" value="VDO46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000640701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000640701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000640701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000640701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6125" checksum="DF9B7B42F1D1A084" modified="2016-09-07" version="1">MSTEEDLVDEYCGWSDLVEAISGVRVSGVPACTVENVPWCWGQGSVDGYGFTDMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGG2</accession>
    <name>A0A183HGG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6573</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006329">
        <property type="protein sequence ID" value="VDO46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGG2"/>
    <dbReference type="STRING" id="387005.A0A183HGG2"/>
    <dbReference type="WBParaSite" id="OFLC_0000657301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000657301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000657301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055491">
        <property type="entry name" value="DUF7063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23205">
        <property type="entry name" value="DUF7063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000657301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16996" checksum="31290A3739540A42" modified="2016-09-07" version="1">MSEENTLPYFHGALLDDDVDKLLESNGDFLLQTKFEQSKKKNKLVLAVKHDHRTIRVPISRLEKGYRISIGYGAYGTVYKGVLLKNLCTVAVKRIDCADKSEQALIDLMKEARVMQLYDHINVVKFYGFIVDREPFLLVMEYCKVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH64</accession>
    <name>A0A183HH64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006723">
        <property type="protein sequence ID" value="VDO48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH64"/>
    <dbReference type="STRING" id="387005.A0A183HH64"/>
    <dbReference type="WBParaSite" id="OFLC_0000682501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000682501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000682501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000682501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8973" checksum="03B099D035A58031" modified="2016-09-07" version="1">MNSRIRTIVLFRGNADTSKCSTSSQQQQPSRHPLGFSIVGGIDSPRGPMGIFVKTVFADGLAAKSGLICKGNENWFYHDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH0</accession>
    <name>A0A183HHH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GT23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6932</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006910">
        <property type="protein sequence ID" value="VDO48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH0"/>
    <dbReference type="STRING" id="387005.A0A183HHH0"/>
    <dbReference type="WBParaSite" id="OFLC_0000693101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000693101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000693101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000693101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16702" checksum="EB29AFD0547D149E" modified="2016-09-07" version="1">MFRSKLAAEKLGHDNVVRQCYRSSIWDETLYKAWSAIVCHLVPNVASMEARLKQFAVILDADEVLLFEKATFLVIAQAQIVQHDDIHRFEKVSNIIKQFKLSCSKLGSQFECMCVRNSKFAAFIDSFTCNTFIMVVLSDATVCKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH1</accession>
    <name>A0A183HHH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006914">
        <property type="protein sequence ID" value="VDO48548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH1"/>
    <dbReference type="WBParaSite" id="OFLC_0000693201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000693201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000693201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000693201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16964" checksum="C3D17EC3A5003854" modified="2016-09-07" version="1">MNVKFGDQHLEQLYQQSLLVHSRAHLLHLQCLWAAYYLFIASIHLLQLDFMLIINAISATVCIILQTFLLFKPTLIRYVLYGTVQLLATTTIALLPYGYSALLPISLVIFTIYALIPMRIIYSAIICSALSVLQLLALIFLPQIPLTISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHY8</accession>
    <name>A0A183HHY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007178">
        <property type="protein sequence ID" value="VDO49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHY8"/>
    <dbReference type="STRING" id="387005.A0A183HHY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000709901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000709901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000709901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000709901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13460" checksum="A29019C344DFEC6A" modified="2016-09-07" version="1">MTIVALLSTFSDINAILGKVPLVGYGANIAFEIWRIDNSYKMKVLYANQWDENPREITQYAPGCGDSIGFCNVTKFIEQSRLLFFDDVQEQCSNGAKNLTSRGSFQIFEFFRYRSLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIN4</accession>
    <name>A0A183HIN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7346</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007613">
        <property type="protein sequence ID" value="VDO50543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIN4"/>
    <dbReference type="STRING" id="387005.A0A183HIN4"/>
    <dbReference type="WBParaSite" id="OFLC_0000734501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000734501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000734501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-like protein KIF2A-like N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO50543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000734501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21069" checksum="BB998DC410626A45" modified="2016-09-07" version="1">MGRRLKEQKNSKKTIMERINVGMHVDIRRSDGRVHNAVISEVRKGTQSVTVEWFENGETKGKEIDLKTLLAINPTLAAPPPSTSSSMNFTLPITNDENHSTAVAASVDLQQKTQNNNGMEIRRQSQRLATARANNVAPVYTATNGNDTGLTTQMNGHNRVSLLQAPTKVPPQKQQRYTLDPSCFEVDSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK61</accession>
    <name>A0A183HK61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4359 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7873</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008519">
        <property type="protein sequence ID" value="VDO52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK61"/>
    <dbReference type="WBParaSite" id="OFLC_0000787201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000787201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000787201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF187">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000787201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21947" checksum="46C695990BAE9382" modified="2016-09-07" version="1">MLHEKLIDTKPSFSRATAAAMANSYLRCPVAFIFAIYLVLAFWGCKDLRIDLKEEYFLTKESEPRTFLENYRAEFGQYEEFLELVFDEPMDYLDPHRKNEILEILEWPVQNQLATKSVSWLKDFARFESTTVYDINPDTFVPIIGIVFLTAENHKKYRNDIIFDKFQTRIIGSRMYIELTAKGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKM2</accession>
    <name>A0A183HKM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008794">
        <property type="protein sequence ID" value="VDO53728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKM2"/>
    <dbReference type="STRING" id="387005.A0A183HKM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000803301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000803301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000803301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000803301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12382" checksum="B1703E51AA6CE3E5" modified="2016-09-07" version="1">MMKKKLYSKSQVAVLIVNLADNVDLQEGRCLKYWPESGSQIYGSFEIHLVSEHIWSEDYLVRSFYLKNLKTNETRTVTQFHFLTWPKKGVPPNTKAVLDFRRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKR4</accession>
    <name>A0A183HKR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8079</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008866">
        <property type="protein sequence ID" value="VDO53939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKR4"/>
    <dbReference type="STRING" id="387005.A0A183HKR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000807501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000807501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000807501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000807501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32063" checksum="3FF630E17280940B" modified="2016-09-07" version="1">MMKKSQGANDTTPEHDLEPPKFARTAFAKLLADWRAVKSLIMLGVKGMQNDALVVEEVFHLNQQHGCSHLDKFAFILLAKCSETHIDTLLNTLITEANKNSEEMKRDPDIDYVISRFIRAVIRMFILLTLLSPAAITVATATASGISQVMTSGNTPPRRIFGPGLHTVSFTGLLSLVRSTSGRESSAAKEAKKKNVTNFVLKCRRIFQTLLNYSINELCNMADSLIAPVRLGVIKPTSVIAQNITGDPLDVIEKFLNAKVDLSTISTTGEDFAAVKFGRKRKVVLFYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL83</accession>
    <name>A0A183HL83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8242</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009162">
        <property type="protein sequence ID" value="VDO54742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL83"/>
    <dbReference type="WBParaSite" id="OFLC_0000824401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000824401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000824401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552566" evidence="1">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000824401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40733" checksum="849B2AD3FC64F55E" modified="2016-09-07" version="1">MKSFLHLFLIGSIVIHYVYSSRITEKKQHRSRRCVCLQIKSLCQCNNERKQESESPIHHQQQQFYREEPLLVASATEKNSTVSQPSSSIAFPSSSSTCIPNCLQGCMQNQYSHCQQSCKNTCKMEQSIPIIKSPEVIPQQQNLRQMMPESRPVQYQTWESNMQKDNAASVLKMNAQIPIKVSNTSALLAESNKPAFPLFSDSIGLNIPYGQVSNDNKNLCTQACMPSCHRQCTQQSTSIIISVPQHQRPLESILQHQLPSESVPQHQLPLESIPQQQLLSDSVPHHQPLSESVPQHQLPLESNVQQSLISEGSLQQEPAAYNNNMPNPTQTPCASICISSCPNKCIHQSTMSSGAFYPSPSPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLD3</accession>
    <name>A0A183HLD3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8296</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009255">
        <property type="protein sequence ID" value="VDO54996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLD3"/>
    <dbReference type="STRING" id="387005.A0A183HLD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000829401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000829401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000829401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO54996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000829401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19448" checksum="80888B7EE1CE8B24" modified="2016-09-07" version="1">MYGGNYDAFINYFLAIHRIPHRSVVYVYKKGEHTYKMPIWVGDVAKGVERTIVDPHVIGKTYEFVGPHCYKLSELIDYMYDRAHLSSRFPHRQYRRRNLNYLYRAYVSALELPYKFFRNPSPLSLEWIRVVECTNDVLTGCPTMQDLGITRLVEFELTGGKHAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLG4</accession>
    <name>A0A183HLG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009303">
        <property type="protein sequence ID" value="VDO55109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLG4"/>
    <dbReference type="STRING" id="387005.A0A183HLG4"/>
    <dbReference type="WBParaSite" id="OFLC_0000832501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000832501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000832501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000832501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10132" checksum="6F11DF4E26B70BE8" modified="2016-09-07" version="1">MISCDQQSCSFGGMCVVLSENHLSDICLCDFNCSASVDDTEAICASDGNIYNSTCFMDLASCKQQKAIYQMTPIHLCHYNGSSNTVLPSLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM39</accession>
    <name>A0A183HM39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8552</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009781">
        <property type="protein sequence ID" value="VDO56225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM39"/>
    <dbReference type="STRING" id="387005.A0A183HM39"/>
    <dbReference type="WBParaSite" id="OFLC_0000855001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000855001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000855001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO56225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000855001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14664" checksum="5C13B9691E9DF3A4" modified="2016-09-07" version="1">MFVCFACGRVFDDEITMRNHVNEIHLSNKDYIFKCRYCYRRFKLKHHLQRHEHTHDLSLVHVCNRCSSSFRNFESLVAHKSRAHGIDENGEKILNLKYNCNKCKQKFGTFIEINVSALGSYSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMP5</accession>
    <name>A0A183HMP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8760</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010164">
        <property type="protein sequence ID" value="VDO57259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMP5"/>
    <dbReference type="STRING" id="387005.A0A183HMP5"/>
    <dbReference type="WBParaSite" id="OFLC_0000875601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000875601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000875601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552575" evidence="2">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO57259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000875601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32584" checksum="42051582E33665AE" modified="2016-09-07" version="1">MFQWFFVVILSFGLLRSVIQGYCSGTNCGGNSGGFSGSSRCIPTNCYHYHQLHRRMLDCGFANCNIGKNVIGDNCCNCCCNRISSLPFVNDNNDRRGDASARTIGYGTSSSTDYNSKDVDANTSAEGSESSSDVSSTSDKTSSEIESNCPPCPPPSPCSSSSSQPLTSSRHENTQLLTKNQALLLLPEGIPIIPSPQLDLLTSGSNFKFNNIQDLHLSTIKPPSSFNQKPPIQDQPVVDNLPSHDCCTRCSSASCMTRNKNAILLAANTYTIRRNRRTKCKSYELAKLMMMRSLFEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMY7</accession>
    <name>A0A183HMY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8848</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010347">
        <property type="protein sequence ID" value="VDO57706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMY7"/>
    <dbReference type="STRING" id="387005.A0A183HMY7"/>
    <dbReference type="WBParaSite" id="OFLC_0000884801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000884801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000884801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990513">
        <property type="term" value="C:CLOCK-BMAL transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF3">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO57706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000884801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9867" checksum="0AFDCBBDC21A0330" modified="2016-09-07" version="1">MAECSSSFSDNTSTFAEKGSKRKTRNESEKRRRDTFNRLIDELTLLVAKGDRKMDKSSVLKCAINFLKQQHCKLYNSTLFKCAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN03</accession>
    <name>A0A183HN03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8866</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010385">
        <property type="protein sequence ID" value="VDO57789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN03"/>
    <dbReference type="WBParaSite" id="OFLC_0000886401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000886401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000886401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000886401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24930" checksum="925385E7692E0481" modified="2016-09-07" version="1">MPVAGGNIPTTMRQAIYIEERSFPHDRPPNFVTDHRISDYTSSRNFSQQSMQSALRSETKICGRELPVMQNSLSLGVPLTLPSQSWRKDPLVVYSDSSEIPINSRDIPKNPDFCCGSRSDYPIVHTESAEFGKGNAREHNPIPSASEKRKSHYRDRHRISRSRSRSSGKGCEASVGKRRVPTKYRDFISVGVNHQQKESRRNYLSDEVYDLLSNLFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN10</accession>
    <name>A0A183HN10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8873</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010396">
        <property type="protein sequence ID" value="VDO57811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN10"/>
    <dbReference type="STRING" id="387005.A0A183HN10"/>
    <dbReference type="WBParaSite" id="OFLC_0000887101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000887101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000887101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO57811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000887101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23079" checksum="1AA9CFDCCCCD0C97" modified="2016-09-07" version="1">MDIIYVFDMFVRSRTGFLEQGLLVRDISRIKKLYLQSSQFKLDIISILPFDFILSLIFYKPVPYMRFNRIIRYPRFSDFIDRTETRSSMPNAFRIFCVIANIVVIIHWNACIYFFISKMIGLGSDGWVYGPLNKQSLPDGVEDTLARRYIYSFYWSTLILTTIGEVPGPKRNIEFVFVIMDLMCGVLVFATIVGNVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN33</accession>
    <name>A0A183HN33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8892</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010431">
        <property type="protein sequence ID" value="VDO57887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN33"/>
    <dbReference type="WBParaSite" id="OFLC_0000889401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000889401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000889401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000889401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23790" checksum="DAE791071BB09D6D" modified="2016-09-07" version="1">MDRSVASAEARKTPERLTKAQEAKMKHKLFFQRVENEVMRYKAVHRHHMQCLKVLMVKNYQFERKAKNEFLAALLKCEAEINATIMAQKESPRYTTVEELESKESKKENGKELEMKTSQKASKKPEKSKQQKISMKEKKTDKKSDKLGEQKSEQVANIKLDEPVKQTSNRKENVEVDNKKTKENNIKTREEETGKGSTGDKTDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPE1</accession>
    <name>A0A183HPE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator complex subunit 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9353</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011382">
        <property type="protein sequence ID" value="VDO59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPE1"/>
    <dbReference type="STRING" id="387005.A0A183HPE1"/>
    <dbReference type="WBParaSite" id="OFLC_0000935201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000935201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000935201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000935201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15785" checksum="75FF25E111AC2D93" modified="2016-09-07" version="1">MSRGTSIPPSQQQNISRHHQQLHQPSVLENLINSPHYGSPTPSSRHLNGSGNQNVADLPFGNTLQQSEERIYAEKLRSLRPYVESLRARAQQCRLEGNEIAASKFDTMCNVLDGKSRVSFEYLLQIESWIYKKQQFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPK9</accession>
    <name>A0A183HPK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011527">
        <property type="protein sequence ID" value="VDO60464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPK9"/>
    <dbReference type="STRING" id="387005.A0A183HPK9"/>
    <dbReference type="WBParaSite" id="OFLC_0000942001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000942001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000942001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000942001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12810" checksum="06C2A0B8116F04A7" modified="2016-09-07" version="1">MRKTGYIAGKQTLAREIYALRRCGGVSVDDVWKLLSKIVCAAEYGYSSRSPTPEQTDSPAVSFFQQALCIPANVASPQRTTELNTFLSRQVHRRRKRRHSPTEFPYKKIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPL9</accession>
    <name>A0A183HPL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9434</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011550">
        <property type="protein sequence ID" value="VDO60550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPL9"/>
    <dbReference type="STRING" id="387005.A0A183HPL9"/>
    <dbReference type="WBParaSite" id="OFLC_0000943001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000943001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000943001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000943001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="17059" checksum="90393477EE5659B2" modified="2016-09-07" version="1">MMPNGAICSSTPSMMSSPGPQGPMPTGPDGQADPRGYMMMSTASNIPYVMHGSEGSMTPGAGGRGSAGPPGSGPEPQVGSLLNGDEMKQSPASTHGGLNGGTPSTAGGPGSQAPVGGPGSVAGAGVGGPGSVHSQSGAPPNAVAGGSQGNGPGNGSNSNSNSGGQVNVSLHTCNSVLFDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ23</accession>
    <name>A0A183HQ23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9585</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011910">
        <property type="protein sequence ID" value="VDO61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ23"/>
    <dbReference type="STRING" id="387005.A0A183HQ23"/>
    <dbReference type="WBParaSite" id="OFLC_0000958401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000958401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000958401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000958401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20468" checksum="1DB299DEF75D67EF" modified="2016-09-07" version="1">MIQNLNKTNAYELLCLSSVDSYALEQTLVFIKTIMSQNEEIYCSDGSKPIYQHHPVAAVIGAASSQVSVMVASMLQLFKVPQISYSSTGTELSEKPRFAYFSRVVPPDNLQATAMAHVVSALGWTYVHAIAVTGAYGERGIDSFRAVAAELGVCIDGDVYKINRRWTNTQFKLVSLLLSYNIFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC3</accession>
    <name>A0A183HQC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9685</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012148">
        <property type="protein sequence ID" value="VDO62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC3"/>
    <dbReference type="STRING" id="387005.A0A183HQC3"/>
    <dbReference type="WBParaSite" id="OFLC_0000968401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF4">
        <property type="entry name" value="CHITIN BINDING DOMAIN (CHTBD2) CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17248" checksum="1368BBDA5941AA45" modified="2016-09-07" version="1">MQSCPPGTMCYAMSGFCCGIITGPVPQQNLPIPVIHHQTPVPVVHQIVIMCPNGSPGTQPCGFMEQCPANNGCYRGVCCPLVCPSGQDATGFCGQTASVTLSCSQQASCISGCCCQQHEPIRMPICPSGITATSSCTVSQECGPGMECSSGGCCPIPFCPTGIQVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR82</accession>
    <name>A0A183HR82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9995</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012856">
        <property type="protein sequence ID" value="VDO64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR82"/>
    <dbReference type="STRING" id="387005.A0A183HR82"/>
    <dbReference type="WBParaSite" id="OFLC_0000999301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000999301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000999301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO64988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000999301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13366" checksum="9A5A3833CE14C53D" modified="2016-09-07" version="1">MNPIEMIISNFYLLYIFLLSIAYCNKDASRLLEDLLFNYNKLVRPINNKTNPLVVYFKLKLSQLLDVHEKNQIMTTNVWLQHVLAISCLNLTKFAANLFCYFLALMKKSSIKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRG7</accession>
    <name>A0A183HRG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10081</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013070">
        <property type="protein sequence ID" value="VDO65694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRG7"/>
    <dbReference type="STRING" id="387005.A0A183HRG7"/>
    <dbReference type="WBParaSite" id="OFLC_0001007801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001007801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001007801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001007801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10733" checksum="67E283298DCE8546" modified="2016-09-07" version="1">MIMHAGSESSDAEKEISEPRPGDKGFIMRARVPRPSQKDYVVRPKSNVEGQFRGATKNRSNSRFDRTQREFKERTKQQRTQRAVAVSINRVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRR6</accession>
    <name>A0A183HRR6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS10174</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013291">
        <property type="protein sequence ID" value="VDO66423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRR6"/>
    <dbReference type="STRING" id="387005.A0A183HRR6"/>
    <dbReference type="WBParaSite" id="OFLC_0001017701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001017701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001017701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO66423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001017701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11568" checksum="01FDDC7E80AB85F1" modified="2016-09-07" version="1">MYRAYQKSADIDEDLAKANELGLNCVKTMQSLLECMMRQADKVEQFKLYQRKNDALHAKYSAQTKGTVVGDDEWGHLQIDAISLFLLTLAQLTASGKFNHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSK0</accession>
    <name>A0A183HSK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10461</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013962">
        <property type="protein sequence ID" value="VDO68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSK0"/>
    <dbReference type="STRING" id="387005.A0A183HSK0"/>
    <dbReference type="WBParaSite" id="OFLC_0001046101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001046101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001046101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552613" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001046101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5262" checksum="484D9DF00EEA0B8B" modified="2016-09-07" version="1">MPSMVLLSFLINARARLSPTATIIHCLDGCGRSGALVTIEVLLMHLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUW7</accession>
    <name>A0A183HUW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11277</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016092">
        <property type="protein sequence ID" value="VDO75253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUW7"/>
    <dbReference type="STRING" id="387005.A0A183HUW7"/>
    <dbReference type="WBParaSite" id="OFLC_0001127901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001127901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001127901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001127901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5360" checksum="AC4BD395F763A1E1" modified="2016-09-07" version="1">MNPDELFEATAQAMLSAMERDAVSGWGVIVYTITKDKVNIKTIKARMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV09</accession>
    <name>A0A183HV09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016247">
        <property type="protein sequence ID" value="VDO75665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV09"/>
    <dbReference type="WBParaSite" id="OFLC_0001132101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001132101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001132101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001132101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11378" checksum="A785A27F5D8364E5" modified="2016-09-07" version="1">MAWLQPRMPRSTEASDRSNTVADRRLLAASIQKSARICYQSSPGAYSQSILYSQRFLFETSVQGYRGFVIVVFISFVNSVIFGISPQLQIEECISMRKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV96</accession>
    <name>A0A183HV96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11407</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016433">
        <property type="protein sequence ID" value="VDO76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV96"/>
    <dbReference type="STRING" id="387005.A0A183HV96"/>
    <dbReference type="WBParaSite" id="OFLC_0001140801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001140801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001140801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001140801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10990" checksum="830FF841535BCB45" modified="2016-09-07" version="1">MWYSENISAIPLKPQPKTPSELKIPECEDSINDCAYGGKCVADLNGYKSCLCPASCPASYYIAAIPVSCRAGKHDDYCMSMSDDYRDKYLLPEPACYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVH2</accession>
    <name>A0A183HVH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016634">
        <property type="protein sequence ID" value="VDO76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVH2"/>
    <dbReference type="STRING" id="387005.A0A183HVH2"/>
    <dbReference type="WBParaSite" id="OFLC_0001148401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001148401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001148401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001148401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17409" checksum="6BF9233327D8D7DD" modified="2016-09-07" version="1">MFQADFSGYQTQYQVFISAIQHLDKIRWHDKQIRVATSKHSNVQMPKEGQPDAGLTRDYSQSSLHRFKKPGSKNYLNIYPPSSTLHLSNIPPNITEEFLTSAFEQRGYVPKGFKFFPFVLLHFDFFLESFKLFFFSIIPIYILYINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVN3</accession>
    <name>A0A183HVN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11539</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016766">
        <property type="protein sequence ID" value="VDO77195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVN3"/>
    <dbReference type="STRING" id="387005.A0A183HVN3"/>
    <dbReference type="WBParaSite" id="OFLC_0001154501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001154501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001154501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001154501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13662" checksum="1B23A759ED005A6F" modified="2016-09-07" version="1">ETKPLEPLHVNNDKLWALTVALSGESYECLTCVASHKFLVELIGWTPEEAIDARASKDRARRKEGSLRTKSAAQEMRRLDLIWEVEFFPPGGLTPIIHKIDTYAQKFDLFDNFWEAIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVP5</accession>
    <name>A0A183HVP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11559</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016818">
        <property type="protein sequence ID" value="VDO77344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVP5"/>
    <dbReference type="WBParaSite" id="OFLC_0001155701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001155701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001155701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001155701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4434" checksum="B8234E500498C8AD" modified="2016-09-07" version="1">MMSTLHCLFIFVVMFLIRLSSASLKLVNLIKLFCMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW22</accession>
    <name>A0A183HW22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11679</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017177">
        <property type="protein sequence ID" value="VDO78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW22"/>
    <dbReference type="WBParaSite" id="OFLC_0001168401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001168401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001168401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001168401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3882" checksum="6B011051B05616E9" modified="2016-09-07" version="1">MAERHNVEEILDSARNLLERLQTIIMELETVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWH8</accession>
    <name>A0A183HWH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyco_hydro_38N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11839</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017631">
        <property type="protein sequence ID" value="VDO79633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWH8"/>
    <dbReference type="STRING" id="387005.A0A183HWH8"/>
    <dbReference type="WBParaSite" id="OFLC_0001184001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001184001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001184001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001184001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6515" checksum="8D84D115864C742E" modified="2016-09-07" version="1">MWSNDPFGHGPSVPYLFTKTGINRGVINRIHDDLKIFLRKHGALSFYWRQFFGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY96</accession>
    <name>A0A183HY96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12458</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039847">
        <property type="protein sequence ID" value="VDP11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY96"/>
    <dbReference type="STRING" id="387005.A0A183HY96"/>
    <dbReference type="WBParaSite" id="OFLC_0001245901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001245901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001245901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001245901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37548" checksum="2359CAD8FC4FA1CB" modified="2016-09-07" version="1">MFDLFHSVLYWILKTYIIYRIIRTVIAFWSTVAIYLIAPLFYKPNFDPYKGRWTVVTGGTDGIGKAYTIELARNGLRKFVLIGRNEMKLQEMKTYLERKFDARVQTYLFDFYDGDYAEMRKFIENIDVGFVLNSVGVGRERMERYGDNPEADRRLLKVNGLGAAEFLSVVLPTMEKNGGGQIVVLSSSQGFRPFPYMASYCAAKVMLSFLCEAIDREWSTIKVQCLTPALVATKMTHYDNNYKSLFVKNADDFAREAVNTIGITSMTTGCFNHDLQMLVRHMFPWTLLKYILLPIYWYHKRRTDASQDIHSVTTDSKKVSFYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYP0</accession>
    <name>A0A183HYP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12602</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039879">
        <property type="protein sequence ID" value="VDP11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYP0"/>
    <dbReference type="WBParaSite" id="OFLC_0001260301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001260301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001260301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001260301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118818" checksum="D904E7B07A9A6E16" modified="2016-09-07" version="1">MALLDPASISLGEEEEEEEEEEILDAGCIPAVGASVVIDEQDGSTDQTISIKNDQIARESSSGTKNGRNFPNESASLRFAQPHFMYQVIPKTKVESNICGNASKITVDQITDSIYSDFIILMTGGEVIPPAEEHRQILDAMVQGDDYTVACDVDDEFLGHLDYVIVHLPSIRLLLTSEQREQVIESAVARFKNDKHPIGACLQLLQKNYIGFPSIIRLRNALMDCLSRLMTTGEDDVDYAVSSLDDSGTQSFTGEDMSSDSILPETTSDSDFAVRKKGTTQNLLHTAIPDNEYDILAQILTRKVKIDDVENVVLREAIKARMKGGLLVGEYWSESNDFLSPGWRIRLRDSGKIIPRISEIDDIWRRCYETMPDCTQKQMLTYLEERYVGISLKTKQRAATKDILLKGSRVQFPSRPRCIGSKPMQYVQIDMVEMECSEYGDRCYTMALIVTDLYSHFVFGRALAEAPDTSLLVRHLMDIFGAFAPPEAYRTYTNDEVIGLVMSDIEKLFKIEIKNIGHGVMNHSNLCASMYKRAAEELGGRERWVEALPFAVIDYNQTPVQCFGDLRISPFEIMFGRRPWRNHSIPPWVRSGLYGENVNEMEGFVEENHMGNTSCATEMCMIRSTPLPRRPEVEERLANVYLSEVSSNRAKISCVLGRYPAKFNDTGHVIDPGTGYLYEVGDCVYLRNSVQEEIYADRPKKRQNESRYYRASIIEVDYQNPDFMYKVCYWDDIIDVDHLPPDQWPGEGSLSAWVSPYDIAPSTADLARRRNVVRRRELEFQCKCGYDFCELVYNQNCPYKLSQACCQRLKMNCPYHSRLKLPPREISMSRPKNATAPVLKLAANGERRLLTIPRRMKSEVDHSSSRWIFQGPVLNTSNISWGRYIELFPSSSNTTPVVGREDQQSNAHFDYDVEAFSAKKRRIQVQYGSACYSNFVYDGNPVVSRLPVERSYGYQAVELYEPKDNLIISNTHELEGLDVDDESIDVASNGQSASPEVSDQSVFLTRGDSKTMAEAGSGKISKIQQSPLQAEVLSMRSTKRISAPPQRLSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYV2</accession>
    <name>A0A183HYV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator of G protein signaling domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12664</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039898">
        <property type="protein sequence ID" value="VDP11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYV2"/>
    <dbReference type="STRING" id="387005.A0A183HYV2"/>
    <dbReference type="WBParaSite" id="OFLC_0001266501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001266501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001266501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047017">
        <property type="entry name" value="RGS6/7/9/11_DHEX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040759">
        <property type="entry name" value="RGS_DHEX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF5">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="273"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001266501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="53123" checksum="D38C8AFDDB1A051C" modified="2016-09-07" version="1">MKIAQSAPLKTLKYFRVAVPQALTGQTLVAFLQELMTFDDLADTLHLATLLLQHGYIFPVIEHSLLVKDDNTLYRLQLPYFWPSHATHTDNVEYAIYLNKRLMRNEQKHGLEVDEVEAYNKLLELLGHMWDFITIQAEMQLKIQKEKKKSDKVVYDSEERAFWRTRRPGQANCLEQHIQFQKREKKLRKRTAAVYQKELERLKFTLKTKPWLKAMKASETMVSWCEQFHDYDPFISTPQPSNPWISDDTNLWVVNTDSVEVPTELRVKRWGLSVQELVRDPIGRQVLETFLESEFSSENIRFWMAIQDLKFSSNEQVERKAHHIYEEFLASGAPCQVNVDSRTLESTMKSLEDKSVARRHAFSPAEEHIFKLMSKDSYPRFLRSQIYKGVLSAAQQQGSKRLGWRNFVFNMGNQRKMPATIKQHKISREDNSHISLPKQLSSDSLSVVKAQTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYV4</accession>
    <name>A0A183HYV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12666</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039898">
        <property type="protein sequence ID" value="VDP11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYV4"/>
    <dbReference type="WBParaSite" id="OFLC_0001266701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001266701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001266701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001266701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17750" checksum="D0B2582635280791" modified="2016-09-07" version="1">MMMPSASAQMLTCGSPWQWMCNNGECIAQYDLCNGIAQCTDGSDEIDCDKRHWQNKYINMAGEEHMKSAIRYGMNEVNPASSTTAVFRFTQFNKWLIALAFILFITLLVMIILRYRRRRNALLRSNRAHGIRKGLNLEQNDGDDEDDLLIGSLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0M8</accession>
    <name>A0A183I0M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNHc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040127">
        <property type="protein sequence ID" value="VDP13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0M8"/>
    <dbReference type="WBParaSite" id="OFLC_0001329101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001329101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001329101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001329101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9732" checksum="1639F8F88993FE92" modified="2016-09-07" version="1">MGKCACSSICNKILFNNRRVPVTKLTYHYDDKTNVQNDFGNLNLLLISEKQNAATMKYERSVGAIWRWGHQVLDRVLYVKFCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Z3</accession>
    <name>A0A183I0Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Locomotion-related protein Hikaru genki</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS13405</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040183">
        <property type="protein sequence ID" value="VDP13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0Z3"/>
    <dbReference type="WBParaSite" id="OFLC_0001340601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001340601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001340601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF558">
        <property type="entry name" value="PROTEIN LEV-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552720" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="8">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="434"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="495"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="598"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="940"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1313"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001340601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1374" mass="154743" checksum="78423307D531253F" modified="2016-09-07" version="1">MISSMVTVSSLLLLSLMDLIYCTPTTICPDISASNRPNYCKKACTRDEQCKKNKKRCLCDGPCGLSCVNPSITCHPLVDLPNGFIRTPGDFLFGSNAEYGCNEGYVLVGPSQRRCQANREWSGTKPECRLLKKCGAPPEIPYAQHDGNSYSGQYELETEVHYNCVPGYHRYNNKGITIAKCLLNREKAAQWFGPDLRCRARSCPDLGNIMNGMRKGELFYYPHTVEIVCLPGYQLIGSSTLHCLSNGQWSAQLPHCKPSECKRPSDPLHGKVLGSSLTYQSRVTYSCKTGYRLVGQVQRICLAEGVWAGNEPTCEEIRCPPLPQLHNGYIEGDDTHFGAIIVFRCLEGMNHIGAPYAKCEDDARWSHPMPICLSGCRIPEIKDGHVVNHMPSQLALHGERLRVECVPKHEIAEVEATMVCRNGTWSHIPNCIPVRCKSWPPRLPNAKVVFTKSSHGAFARYECNEGYRPSGVHNTVKCLYGKWSSEGEPFSCLPVLCEHPLKTFGVLEGGQIMLEGQMGAYDYAQYISEVEEGRSISFQCKKGFVLLGSPKLLLPNNPFFWATCVNGNWMPRKKPKCVSQTHPMVEGQIAWMRRRRSVECELIVDDYRRKIIVTKGNNNPTEIMVICSEGFHFENAQADGIISCKNGRWTPEVPKCIPGKYNCRIPIRNHVFFLDIRSERILQSDDLIQHGSGARMICLRGYELQGNDKFECNRGMFIQQIGHCRPKHCKLEESESNKYSSNKTELHHNEEIDMICETDVIRLKCRFGEIHPKLGCTDDDSLLTSCRRPNDDQPFIAYRTTNISGRSVRLDMSVQQATFPKNTIIQYICVNNETIDKANAIECRNGEWFTRLLPCIKASAAPFVTQSDGMCNMPNLASSYKILNIKNSHLSTKSRFARGTNLKLGCAVGFLIEEDRTMEMRCRRGKWITAGMLHCYSDVQSCEYRMNERSHLIAFSAKHRQQITFNQRFADGTELIFSCQEFGMHQFMGNAIIRCRGGTWVPKIPRCIALDPLNENDSAPPINLELGRSLHTITPQGYLMVNISTTLRLQCLFPRRKGQPRWEVSTTYRKYPQSWVEIDLPGKPSIDAYELIVTAARPEDGGFFHCILPSGHRNTVKIIVNDQKCVPLTNSTNLQIFYTSSHLYIGTVAQFSCESGFYVDGPRSSTCLNSGKWSHTLPKCRALQCPPLVIVDSEMKVVVTTFRAGGVARFSCSLTHFLDGNRTLKCLPHGEWSGIVPQCKSVKCQTPKVPRNGAIVGEVKDKYNVREVVVFECRRGYMLTGTDYSVCQANGNWTFVDVKCIPVCRFPGKPEQGDSTSPAKAYYLVGEKVVYYCTSTEYRLDSENVLECISSGKWSQKVPKCVSVEKSYINKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I140</accession>
    <name>A0A183I140_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13452</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040206">
        <property type="protein sequence ID" value="VDP13787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I140"/>
    <dbReference type="WBParaSite" id="OFLC_0001345301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001345301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001345301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001345301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32724" checksum="EC2A99A1F4DEF1E0" modified="2016-09-07" version="1">MTSYNNYNTNNTVAHNNNNVSNNNISKNNTEVTTVATTNNSARPPCSSSGVMINNSLIVPGGTKPSVGTLPKRDFHFKRIEIEETPKWFVWPKRNKENKHVTDDKHTNHDDSSKSSANNLISKPEMLPNPSIAAPAMSQNTTNLANASNSPQQNLMGQHNLNHMTSAQSGSENTTTQSDIKKHRQHDVQYRTTNSVTTSTELINIPSSESNSHTILNSEPSTYLMRCDDRISESAPTTFQTFKILSISKKTLENSGDDDDLDPANYVVSNCRQSHSQPIKLLSGPTTTNDMIKEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I196</accession>
    <name>A0A183I196_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Insulin-like growth factor 2 mRNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13508</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040235">
        <property type="protein sequence ID" value="VDP13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I196"/>
    <dbReference type="STRING" id="387005.A0A183I196"/>
    <dbReference type="WBParaSite" id="OFLC_0001350901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001350901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001350901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22403">
        <property type="entry name" value="KH-I_IGF2BP_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="191"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="303"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="459"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001350901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="559" mass="60560" checksum="7CE3B8A92F73B981" modified="2016-09-07" version="1">YQAVPQHHPITFQQGPSHYSRPSIGAGPVANNIQQRQSGHEVGGNGINRGTGVHQSSVPSGSITQQGMHQSGTVSGDGSHSIAQGIAPLAASLTPHHCMPSSQDMPLRIVVDARYVGAIIGQGGSNIREITKESKARCVVDVQRAVRDLTKNAEKVISILGQPEGCSKACIKILEVVRKEMEKDNTIAQHPDIELKIRAHNQLVGRLIGRGGATIKKIMEETGAHIYVSNEPTLTRDAYTLMPPYAASSLCGSDMSMHLERTVTVKAPTMSVTGYLNAATGVPTAQYVRNTVGTTAIGAGQQQVRTVHMWVPNNMVGALIGAKGAHIRSAIRLTGAQLRIEGSGTTKDKKDSKGEENNEKIDKENITASESVNKDMVETNERVNEQGKDENNSDEKQNGKKEENAEKAVSPKLSKDKDKDMHAEERLVTITGNDPQQYKAQFWIYQRIAEQSCHYMDEVRLCTEISVPSKLVGRIIGKGGQNVRELQRMTGAQVKIPDDAGDDETQKETTVRVLGNFQSSQAVQARLGQLINDFSQRLNIGPANGQNTSNTQGICRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1C6</accession>
    <name>A0A183I1C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATG16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13538</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040254">
        <property type="protein sequence ID" value="VDP14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1C6"/>
    <dbReference type="STRING" id="387005.A0A183I1C6"/>
    <dbReference type="WBParaSite" id="OFLC_0001353901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001353901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001353901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001353901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="34011" checksum="4B8E72A678366EC8" modified="2016-09-07" version="1">MDETGKADNSFRAAIIQQLERRNVVCRQFDSLFTSYCELTEYVANIVRAGRIRPGSSTSLAGSSDRTTELEAELADLYRKKEQNDQQLIETNNRLSVVMRELSAVNIIKEECQKENQKLKKKLKEREEELIALEEANTLLKDEHFALQACVLIFLLASYNSIENKYREALEERNNLVERIKDLKEKEVQWFNEQNEREQEERRRRLAADIDSALNVSHNNEDKTYGFEIINSTNQVVDYRGDIIPNYCKTKLDYGDDINDVLWHPNGKMFAGGGSDHKLRLYKLVDDKFEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1D0</accession>
    <name>A0A183I1D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13542</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040256">
        <property type="protein sequence ID" value="VDP14025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1D0"/>
    <dbReference type="WBParaSite" id="OFLC_0001354301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001354301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001354301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001354301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10589" checksum="FD4E622E0DE222EF" modified="2016-09-07" version="1">MTITMLNKHRLPLHVHARDHQLNPKNSVLHLSIIIIGLNRQNVIGLQNVIIIIQGIREMKGDERGRSGEQKKTDVIELEVEMVDAKLLRRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1Q9</accession>
    <name>A0A183I1Q9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MaoC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13668</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040325">
        <property type="protein sequence ID" value="VDP14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1Q9"/>
    <dbReference type="STRING" id="387005.A0A183I1Q9"/>
    <dbReference type="WBParaSite" id="OFLC_0001367201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001367201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001367201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF56">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001367201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36003" checksum="E87F195F2D14DEA0" modified="2016-09-07" version="1">MGQLCFKASISLSLVEGAMDPEKARAHGSIQSELFRYTSRDTILYALAVGTSVEDQLQYLYENHNEFAALPTFVVGPALQAAIIEIGKWPGITFDLSKILHGEQYLELFTRVPTEGEIRSIISIPAILDKGKGAVILIEVNRVSKFFAVTTYDEQTKTKIAKQQISLFQLESGGFAGSKTSEHEIPCQPIPQRDPDYVTEQKTDVSQAAFYRLAGCDLNPLHIDPEFSAILGFQKPILHGLCTLGFCVRHVLKAFAGGSDEYFKSVKIRFVNPVTPGQTLRTEMWKEGPRIHFQAKVKETGKIVVANAFVDLHEVPESVVSKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2K6</accession>
    <name>A0A183I2K6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13968</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040506">
        <property type="protein sequence ID" value="VDP15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2K6"/>
    <dbReference type="STRING" id="387005.A0A183I2K6"/>
    <dbReference type="WBParaSite" id="OFLC_0001396901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001396901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001396901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="4">
        <location>
            <begin position="426"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001396901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="635" mass="75701" checksum="A29D07B20DED2770" modified="2016-09-07" version="1">MAQTAHLVKNLLDYLHHDTSHEAFDVWSTEYERNFLRTLSALKTHDPKLYSGQKFFTTEDGETSTGNSVKFKKKDTAMFLKDYERKLVLEKKGEISEDEEEKQTSTPGYYEEQELIKRELKAVLDDQNDDAEPLLQQRIKTEEEVKKEEDQYYEWLKGQRDEDLPGVEELKGLKEAWNDINLDENEKFLRDYLLNKKYDVEGDDSVPSYEEIVNVEKDEEELERENEFERKYNFRYEEPNQDFIKHYPRVVKQSLRKKDERRKQRRDAYKERKKLEKQARKDEIKEMKALKKKEIEEKLKKLKKLAGDDDLPLNIDDLEADFDPTTYDKRMKEIFDSQYFEKSMEENEEKPVFPVTSDISTDDSDYDTFEVNKEKKENKIENVNEDYYNDEILNPEKKLSRKKKKRNSRFLEAVLKKKPLFNPEEKSFEEYFNEYYALEYEDIIGDGLITKFKYRNVPANDFGLTTEELLNADDRQLNAWASLKKATAYRSEAEELYDIKAYKKKALNLLKKKRIFSTDFGGKVSKKLAEDNVAGDMEHTYQIGKTPTKKKRSSEKFPKDVNPRKQEENNTVAQENHLKNSHDFKKNHNTFEQFSSTVDIDDSRLRAYGINPKKYKNKLFRQQQNCTRKGVKRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2R7</accession>
    <name>A0A183I2R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14029</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040548">
        <property type="protein sequence ID" value="VDP15316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2R7"/>
    <dbReference type="STRING" id="387005.A0A183I2R7"/>
    <dbReference type="WBParaSite" id="OFLC_0001403701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001403701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001403701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP15316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001403701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39796" checksum="604B4A3A409E0796" modified="2016-09-07" version="1">MVNSLVKLWNPARRITNCYSNEVQKLLVDLREIDQRKTVLQKEALAEHEATVVGIYKKRLSLHEMQQRMRDKIAQKKRMDVVSQDRQRFVRVLTQIMSKTLRIFHKVPSLEGKLLVSQQDVMNLVVPSTATNLEKALLQPKLHNKHSDGIQMDLCFAYRSLLDLSLECKNIPVYRWLARFQEYVMDLNNISPVLRLFRCIGELEFMGILKSASERNRNKVMDSLSEDSDDYSILGDALRDASCNKNGEINFDVCKEGINQSDIQTVAFCNLIKYSLLMFTLPFIAMYCFYLLIKDRVGWTASSALIPAALVAVLVVYLIIAIFVYVAYKEEKNDAELQEILKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3I8</accession>
    <name>A0A183I3I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040749">
        <property type="protein sequence ID" value="VDP16410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3I8"/>
    <dbReference type="WBParaSite" id="OFLC_0001430801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001430801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001430801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001430801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41373" checksum="5AFBCCD7D55F9B1C" modified="2016-09-07" version="1">MPNPPAKEDTWAFGPIGSPFPDNPVRAIGQQNMYVALWYKHGKPIHGRAWNNGGVIECSFPYIKSELTGIKDLGGQIQVLQYKGDHLTLGFWYNWIKYKDRFEKYEKGAELLRCGDSFPIFWQDRKEGALLGYVDNKTEIARFSHDGKVEECSGGALNDMLIIVREFKGGPPNCTCHECSTGPPKPVVRVTLDEWSDFRYGDPWPTAGKPVQALDRALNTLPNENPNQYVALWYQSGEPVMGRIWNDGGKIAACFGWGGHEYRKNIGSIQILFELPEQVRGFDYAWKPFKEAAKFGDKEWIPVHVDHHKGNISPAVLIIDGKEILGKADIRNERATVGYDGNEKVYVGPAVHTCVVLCRKAKPGYTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Q6</accession>
    <name>A0A183I3Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14368</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040797">
        <property type="protein sequence ID" value="VDP16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Q6"/>
    <dbReference type="STRING" id="387005.A0A183I3Q6"/>
    <dbReference type="WBParaSite" id="OFLC_0001437601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001437601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001437601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="128"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001437601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21942" checksum="BD2DE067B99752D5" modified="2016-09-07" version="1">MSVSAASTSNANSSSNEPVTTSGSSLGASENPSASDEKVPVMDAENIKFEETQNGEEASSEQHVDDGDNDDSAADVGSAAPSTNGWESPRQEAINGVVQPRVIPPPGKPTRHTNQLEFMLKEVLKPAMRHKHAWPFMKPVDAVRLGLPDYHKVIKRPMDMNTIEKRLRNCYYYSAKDCMQVSRLLFFELETVLAKEYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5Q1</accession>
    <name>A0A183I5Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15063</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041555">
        <property type="protein sequence ID" value="VDP20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5Q1"/>
    <dbReference type="STRING" id="387005.A0A183I5Q1"/>
    <dbReference type="WBParaSite" id="OFLC_0001507401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001507401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001507401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001507401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33492" checksum="27D4B8CE49FF9329" modified="2016-09-07" version="1">MMMPLIEMEDVLYKPVVVSKLRLPPPIPPTERLLRAMDAFYAPQNLENQRDTDGWERHGLLEYYAKKTEIKKKIEEQLKAEGKTLEDAIENVYIEENNEEKDEKRNYRHSSSRSHHRSSSSDSSSSRSSYSSDKSRRRRSRSSHSKSSASSSSRSRSRSLSRSNSRHRRSRSRSDSPRRQRRSNSRSASPDTRPSFGNSKQIGSRSPTPKFIPPSGPPLRLSSANKGAQLLAKMGWQGGGLGAERQGIEEPISGGEVRDVVDQFRGIGSKPDMYEEYRKQMSGYHKSRSKRVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6K9</accession>
    <name>A0A183I6K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15372</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042028">
        <property type="protein sequence ID" value="VDP21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6K9"/>
    <dbReference type="STRING" id="387005.A0A183I6K9"/>
    <dbReference type="WBParaSite" id="OFLC_0001538201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001538201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001538201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001538201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21775" checksum="EB10B7245DE14454" modified="2016-09-07" version="1">MLLAHDPNEPVWFGCKFKPFIKQGYMSGGAGYVLSRAALKKFVTEALPDPNKCRKSESGAEDAEMGKCLAKVGVKAGDSRDAEGHHRFLPFVPAHHLTPGHIDKKFWFWQYTYYPIEQGPECCSDYAISFHYVNPSLMYVLEYLIYHLRPFGITKKVNSQSMVAAYQLAVKNMGPDDVFRKTFAPNKSIISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I805</accession>
    <name>A0A183I805_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZNF292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15867</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043096">
        <property type="protein sequence ID" value="VDP24414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I805"/>
    <dbReference type="STRING" id="387005.A0A183I805"/>
    <dbReference type="WBParaSite" id="OFLC_0001588001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001588001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001588001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001588001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8522" checksum="2C218523253D93AE" modified="2016-09-07" version="1">MEQNLIATITDHISSRWDGVPLSSQSALLEAEDGASVITETIKEDETQETKTCVKRAGKVHLLTTYSMKKLTDLNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I897</accession>
    <name>A0A183I897_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043363">
        <property type="protein sequence ID" value="VDP25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I897"/>
    <dbReference type="WBParaSite" id="OFLC_0001597201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001597201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001597201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001597201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3695" checksum="9954A7A9414A9381" modified="2016-09-07" version="1">MIYGNWSDEILLFMMIRNLAPVHLDQFTKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8J2</accession>
    <name>A0A183I8J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase_M24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS16054</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043810">
        <property type="protein sequence ID" value="VDP26563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8J2"/>
    <dbReference type="STRING" id="387005.A0A183I8J2"/>
    <dbReference type="WBParaSite" id="OFLC_0001606701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001606701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001606701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP26563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001606701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10630" checksum="7848C998ABAC03D3" modified="2016-09-07" version="1">MHKLAEVIILSHLRDAGILKGDLEEMMEARMGAVFMPHGLGHFMGLDVHDCGGYLGDAEPRSTLPGLKALRTTRTLQERMVITIEPGCYFIDTVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TV82</accession>
    <name>A0A3P7TV82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000215">
        <property type="protein sequence ID" value="VDO26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZF5"/>
    <dbReference type="OrthoDB" id="5954366at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="239" mass="27616" checksum="D2BBA2284F8285EE" modified="2026-01-28" version="1">MTFLIKSDIIRSDSDGSNCKQFTQNNRRVYECVNVTFQNISRIPSGTMVLKIVNSMMKQLSLLNNTEIVTVVMNFCNLSDVLPEAFVFATNLRKLDLSHNLLRTLEFKSGYRFIIQNLVISYNDLIAVPLLYSLQQLTHLDLSHNKIRYLAGYNLLLPSLEVVDLSYNHLHVVKPTNFGDMIRIIELDECPWRCDCHLRDFVAFQRKTLSAKSSRCYEPARIRGTKWDDLSLKVSEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UQ99</accession>
    <name>A0A3P7UQ99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001664">
        <property type="protein sequence ID" value="VDO34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H5K0"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13113">
        <property type="entry name" value="Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF116">
        <property type="entry name" value="ABNORMAL CELL LINEAGE PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="337" mass="37978" checksum="CFDAB2B5526B9971" modified="2026-01-28" version="1">MGFMRKRTDINLIEHYAPLLYGYLLCIALLEEKAYGVPTTPPEKLTQGCSPELLHLRSHRHFHVLCRSQPAIAVAAYEGMQDAMNQCKEQMRFQLWDCSQIITVLQDPPILRLGTRESAYLWALSSAGAAWGVATACSQGWLPDCSCSGRDELKQNWEWSGCSYGVQFGIITSRKLLTRSTTSRSPLRKLEKHNLKAGRLAVKKTLISSCKCHGVSGSCDQKTCWKKTAPLSTIVQHITNKMHKARRLPDANSPAKNAELVYMEDSPDPCRSVRITNRVCNWRNETSSQGDCSLLCCGRGSKVSHELISYQCDCQFVWCCHLKCNTCLRHRWVSTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UVK3</accession>
    <name>A0A3P7UVK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000321">
        <property type="protein sequence ID" value="VDO27184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6136201at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009816">
        <property type="entry name" value="SPATS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623:SF11">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07139">
        <property type="entry name" value="SPATS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="462" mass="50507" checksum="DEA688EA98E59CF5" modified="2026-01-28" version="1">MSMQQYRNEKKVMEEAVAKVREVVHTASKNDIILALHNFDFDINKTIQAFCDDGAQSALDSWKRSGSSNKKNQKKKKMAKDQTVTAATASNPSCTSASSSAPRAVNGVISSVINGVMEVTNSRNRSETVALSTSESQKLVASADVPKVPSASFIPFKSAAPNEIENFNNGHANEDIIGLKDHNRQIEKIETDFENQISIAEENVRNSFKCIRQILVERENHLLAELQRTHDEGMRFFNERRLQSCELYDRAKRMSAMSDREQAELRDEIARFNAVKQNEEGIAFASRFHCDSAELVKLIKNFGEVVAVNSIAGSDANLIVRQVGTAVSAYMMKHSTSHSSIVSSLGEDSGLGQISPVGNEDRKNIAEISNGGILMKSDALTAEQLAELNKKLQESLKAQGIDASILSGIGSRNGMPVRRRPPGSGRGGQSNSARGGRGRVQHSNGNSKTSLVRVPDLFILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UZP8</accession>
    <name>A0A3P7UZP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003570">
        <property type="protein sequence ID" value="VDO40466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867425at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="181" mass="20903" checksum="03B0D520849E3997" modified="2026-01-28" version="1">MVEHLKDTVNCVASGKEQHITTTEIYEMLQTKNKQSRWENAFQFPPVLRNLSNRSHYLKTNLDEKAEISAWIKMDCAETAIKLKKYIATFEENSMKMIGAAVLRKKRLHQRNFTKNILIDVRIAFMEVSSVERQFTDQSASSKNIQRQGFVTVNNDQCYSQSWLSSISPNSSMETSITIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YBZ5</accession>
    <name>A0A3P7YBZ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01003032">
        <property type="protein sequence ID" value="VDO39058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YBZ5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000183">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="4">
        <location>
            <begin position="229"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="356"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="536"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO39058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="723" mass="82091" checksum="37EE14EC527D3A34" modified="2019-02-13" version="1">MFHLKQCLCSFQNYLGEKLVAYFLFEADYSNFPRLPSPWQLQNRILIKNKKMISEPNAGLRMDKYYIKNECDAIIEQIDGFYGTDEDDFEEFYDNLDDEEADSESLGVANRLSRGTPYESSSEAEEEQKYAPSRLTHVRSIKKIPGAPVARELSNLVNYMQAAKFKGFPGTVDFVHRWEESTKFSMLGTIRPVSYSLRNAALLNEENTPSRRLRNAALLNEENKLKSGEETRFPSNPSLKPNSNASCYQVTSLNESSARKLSSFKRSGFAGYFRKHPLELIDYSRNRIVRTYPSGMRIDSSNFNPVQYWAFGLQMVSLNFQTTDTAMAINAAMFEQTGNCGYILKPRILWDSFHPNYNRFNPLCKDTTSISALLYTITVISGQHVCPNQHNASTYVEVEIIGIPADSAKEKSKTVSRNSVNPIWNHTSTFRIAFVYLAFLRISICDSTNGRCMAQRIVPIRCIRAGYRHLPLRTPTNVPMDQGTVFLYSHFEQEEHINLHDEDSIVNCNIDQQLHPQTFNIYSTAKIKTVPILKRQIFVLRISGLYNDDTPVIVHAESFSTVRNVVQMALTNAGKNADTAEEYVLFEVSDNKILSRNDEQQHIHCGHRILPSKVPIMDFVACWNGSMRHFIIKKKGTAILDDLDPSSRAWISSIIKGSAGTPSSSSTIQSPSCALSSSERKANNRSSEQPPVLQRMKSLDPDIFSEKKIITGNIFCRKSLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z1Q3</accession>
    <name>A0A3P7Z1Q3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014765">
        <property type="protein sequence ID" value="VDO71273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z1Q3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219:SF3">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15987" checksum="FE513C622B207BAE" modified="2019-02-13" version="1">MLEYIDGDKKTETAFHPINSLHYCAAVRYVNVTGYAIEGGGERFLPLDSPFASGEDSQHPPIFAAIFRRTTGIKVLECHAFICTNAKAANALVRCCFHAYAESMYIKLDERLPALKSIKEASRSASPPSEPLPRFSANFFIHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BY92</accession>
    <name>A0A3P8BY92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040299">
        <property type="protein sequence ID" value="VDP14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1K9"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="320" mass="34865" checksum="8F67546C81732208" modified="2026-01-28" version="1">MGREDKAAWKANYFVKIIELLEEYPKCFIVGVDNVGSKQMQEIRQAMRGHADILMGKNTMIRKAIRGHLQTNPDLEKLLPHIVGNVGFVFTNEDLSEIRTKLLENRRGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKISRGTIEILNEVHLIKVGEKVGASESALLNMLNIMPFSYGLVVRQVYENGTVFAPEVLDMTSDDIRARFLKGVQNVAAVSLAIGHPTLVSVPHSIANALKNLLAIAVEANIEMKEAEKIKEFLADPSKFAAPAAAVIASVPSAPSAESEALSKKEEAKKEESSEDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYI0</accession>
    <name>A0A183GYI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Liver stage antigen-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000085">
        <property type="protein sequence ID" value="VDO25274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYI0"/>
    <dbReference type="WBParaSite" id="OFLC_0000028901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000028901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000028901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000028901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14595" checksum="0A77A415B46C265D" modified="2016-09-07" version="1">MAEVEVGGTIEIDDIETEEIQTKVMEDDAALDDEPVPAENSQVVTDTIADVVDEPNNAELINIEEMEEGQLEENNEISSVEAMEQAEERIEAEEEPKEIDEAETEEEKLTQVMGEEAVEEQIVEDRTEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H016</accession>
    <name>A0A183H016_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PNT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000328">
        <property type="protein sequence ID" value="VDO27227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H016"/>
    <dbReference type="STRING" id="387005.A0A183H016"/>
    <dbReference type="WBParaSite" id="OFLC_0000082501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000082501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000082501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000082501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43014" checksum="4D653ED261ECD627" modified="2016-09-07" version="1">MVLGGVNGTKLENKTLRFSSPRLLSMIPDNVKDQINIFSPSLLSMHDKGEGLEALTSISNLMKVADNRDYEEWLNFIIEASGTTDAIQKLKEKQELDWLPPAYKSMPRGIDGQPLYFTKENVTEIDPELGRKMELFENLTYSLTPKQMADFNTTGFSMMTPKQLMMFYGPQSPLNDSKSLEFFLSLSEDDMQRLLLDDIRKLANKHSSLKIRQKRQNIFKPSGFKANILSPGKFSLSPSILSPGAFSLSFLSPSVFGAALLNPSAFMATIFSPSLLAPAVLSPSAFTPVVLSPSAFSPGFLSPGALSPAILSPSMLSPNVLSPSVLSPAIMNPFALNPSILSPSALTGLIMSPFALSPSFFSPGYVGAVIFSPNAYSPLFNSTGKGITLLFSPSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0T7</accession>
    <name>A0A183H0T7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS1097</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01000471">
        <property type="protein sequence ID" value="VDO28229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0T7"/>
    <dbReference type="STRING" id="387005.A0A183H0T7"/>
    <dbReference type="WBParaSite" id="OFLC_0000109601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000109601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000109601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO28229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000109601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15609" checksum="7AF968038D6AEA10" modified="2016-09-07" version="1">MVQKDKIEKLFGSAICTGNSNKLTIEMCLPSLETIIKDVVKKASDLKVRSVFVSSDRNHYIDELKQELAPLQIVVEHRYPENLHINLAILSIADHFIGNCVSTLSAFVYRQRKYASSVPRPSSFFAQNYFTENKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3J1</accession>
    <name>A0A183H3J1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001103">
        <property type="protein sequence ID" value="VDO31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3J1"/>
    <dbReference type="STRING" id="387005.A0A183H3J1"/>
    <dbReference type="WBParaSite" id="OFLC_0000205001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000205001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000205001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000205001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7610" checksum="1D66C6BA223D25BE" modified="2016-09-07" version="1">MGCKRWTAKTFKLPTMPNYPESRVTRSRAFAQVGLDYLCPILVKTETGSSKRWIALFTCFTTRAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4K4</accession>
    <name>A0A183H4K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001386">
        <property type="protein sequence ID" value="VDO32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4K4"/>
    <dbReference type="WBParaSite" id="OFLC_0000241301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000241301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000241301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000241301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7735" checksum="94E6701F801CB917" modified="2016-09-07" version="1">FKVYNCKSFFLKEKKKAIALRTIVICLSATAGKTLSHENTVVRVDTTLLKQQRRAAGISSNMGSPLPGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4U0</accession>
    <name>A0A183H4U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2501</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001449">
        <property type="protein sequence ID" value="VDO33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4U0"/>
    <dbReference type="STRING" id="387005.A0A183H4U0"/>
    <dbReference type="WBParaSite" id="OFLC_0000249901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000249901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000249901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="5">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="83"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000249901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28011" checksum="6C3C69693D2F35B8" modified="2016-09-07" version="1">MQKNYSKYYTEFERPPFAPTFYPTEEEFADPISYVAKIKPEAEKYGVIKVKPPPSFRPPFAIDSEKFNFTPRIQKLNQIDALIRARLIFDAQLASYWHMQGYTLEIPTVDNKYVDFYNLYKVVMETGGADTVSAQKRWSYITKKLGFKQQRTNKIKTLYFKWIDVFQKLINQNGDDEENKNDVCSSTTNDAESGQAEYGRRRIPQPRTKSMAGLRSHAMVINESIYEQKLLESSSMRDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H539</accession>
    <name>A0A183H539_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001525">
        <property type="protein sequence ID" value="VDO33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H539"/>
    <dbReference type="WBParaSite" id="OFLC_0000259801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000259801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000259801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000259801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8827" checksum="2B2EBD71BD2BA360" modified="2016-09-07" version="1">MSRFSETDKDDKVLSEEQRFYYLRLMAKPSSGKYEPIKIKFVRWEPPSPQQESPVTDDDLEVCHIIIYREAFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5B7</accession>
    <name>A0A183H5B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2677</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001589">
        <property type="protein sequence ID" value="VDO33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5B7"/>
    <dbReference type="WBParaSite" id="OFLC_0000267601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000267601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000267601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000267601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22444" checksum="748B450796C5BF2D" modified="2016-09-07" version="1">HTRSSQSSISFESVTASELSIDEAFCLSDNAVAPLFLNFSCAIRFSNMDMCTFPIDHLPSCVMQLLKQCSNISKKNFTAMDLIGISFDIYVLSWPMRQFTLTQSDSCTISPKTLKNSSESFHKFTTYFDFDRPYSTTTSDVISQLPRPENEAVRRLESGITRLLHMETIFALSRYDDVTLDTLFKVMVFIAKEVNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N8</accession>
    <name>A0A183H5N8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2798</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001701">
        <property type="protein sequence ID" value="VDO34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N8"/>
    <dbReference type="STRING" id="387005.A0A183H5N8"/>
    <dbReference type="WBParaSite" id="OFLC_0000279701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="416"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="645"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="881" mass="98955" checksum="609DEBA097CD26D2" modified="2016-09-07" version="1">MCILYIFLELRPLVRLFAIDSNNNVFSISNWSPSLSQVLVRMKRQTPPLPTIIEQSIAYIGNDLYSIRKDSDSVQSFLLRLDPNNVENILHKVSIGGEIGKVDALTSDWVANRLLFVSTAYIMQLPLDAIQSLSVITPRRIMNLSSGAGDAKQLLFDPFSNTGFLLTKNGSLFTLDFSKGIEENMALRLECLKSETISWMMTDFAWNLASLPAIYVLTWNGMVRVDLTSSKCEEIKFEWEKFGEKGLKSILSFAIADKLYIFVTSSLLVVYELGSSTATPIAVNGSPLKQILVATQSTQPFPERSCFILPPASEIKFTVQNEERSGALISVNEPQLPNVCPGISLPPTQYEIHFQRRGSDKIRNIHSISNVLHVENGILDKDADYDISVSWFNRYTPASEASAVQMLRTGYGFPSSPQDPVAFALTPDVVLLYWKLPAKPNAPISEIKYMISQLTATQLSPSAIGAQQFDGAYYATATTDVVSCLSDPCSAKISNLRPSTDYKFWVRAIHESHLNKQFVDNAEGNSIEASVRTKDIAGTLRLDNITGTTVVLRWNSLDPESHPKRIFIQYRIVAMNAIWKSPYNASFEGHEKSVAVVVRALHSATTYDYRFAAEYADSYRYANYDYFYNETFLQVSQQFRTKPGTPSAPASIRLVQEYDEWIVRWEKPLNDGGSPITSYALEFRPNEDAEWEIAERGLEGGCLWWKPLRINFLAECAEFRIRAANSEGFGAYAYSKHHNDRLGESHTQSLWIIIITLLIAILLLTAVIAVLFIYYQRNDRRRNKIRLQDISLHGYTNSIRRNILPPQITNDLKTIPRVPKNSISLLRIIGKGGFGEVYEGVADGLPQSPAKAIRVAVKVSFTFWISAVTLAHISNKVILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Q5</accession>
    <name>A0A183H5Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2815</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001717">
        <property type="protein sequence ID" value="VDO34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Q5"/>
    <dbReference type="STRING" id="387005.A0A183H5Q5"/>
    <dbReference type="WBParaSite" id="OFLC_0000281401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000281401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000281401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000281401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50954" checksum="2AA97AC46227675A" modified="2016-09-07" version="1">MSNKDLLLRVEHVKYRMPGAAKSPVGTFYVYEDRVEWLDNVSDEKLVVLFSDIRGQRISPPNKTKTQLQICKHNEEQATFVFVNPLGKEASFMHVKDRDLVKEMLQQALIHHRQIANQNAAQMLKYSKTKELEAKKKILERNKHLQELYKHLVASKLISAQDFWSEYYQNNDTDSDKLGVSSGFLSSIAQSEGTNGVKLNLNIDTIQSIFRTYPAVERKHLELVPHEMTEQEFWAKFFQSHYFHREREIASSPSDPFSDCIKADNAEMRKLLDTKIAHKTLDFSYIHDDPLINNISSSSQYASSAKDILMKRFNYYSERVLLATAENEMPTIANFEEQSNEESTKVDKPKSEEDENEIILESEELKSDEHEEQLDYISLAVNGVVRPTKHYTDEQAQAYRDIVLRVCEAMPDNEDSDDVSCILSIPKKKKNSLEDFFRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6F2</accession>
    <name>A0A183H6F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fascin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3064</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001931">
        <property type="protein sequence ID" value="VDO35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6F2"/>
    <dbReference type="WBParaSite" id="OFLC_0000306201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000306201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000306201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000768">
        <property type="term" value="P:syncytium formation by plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.60">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3980">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029213">
        <property type="entry name" value="Fusogen_EFF/AFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043076">
        <property type="entry name" value="Fusogen_EFF/AFF_dom3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415:SF1">
        <property type="entry name" value="CELL FUSION PROTEIN AFF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415">
        <property type="entry name" value="EFF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14884">
        <property type="entry name" value="EFF-AFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000306201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47898" checksum="D380ECB1B78B6DC5" modified="2016-09-07" version="1">MDESGKQIQETSTTVADLTLKETLCLNFTDGIRTQIHTIEYVRMEQQFPISASYKFGIPLITTTCICDCAGAEEYCKIDDYKYKNCTKSYVCYRTYHAHQSSSGCLMSSKSEVCCEVAIEPYGGRTYTAVKLTQPDTVIILRHRIYELVSNRWTEAASEEFEAVVNKGSAKMETIDKRQMEIKTTAGRVIREMLSGMYYFSNDNRVLMMGVRLNEPTESDIHKLGWLRKNGNSWLIRNGIIKITDSQHITIENCKGQRYLTRYNAEYFITYDERIIDLDLGYPVDEQNWIERAEILTDDRAIRIIHAEGTVIHVSVSSGTRPIVVRHASHLLTFNGTIRMDEQSNRFLNLTILGGKGTLIGYVHRSEDKSSTDWSFSIEIGTATRTKFTATIGGIPPGIISDRFVCLQPAGDANAEQCKWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6H6</accession>
    <name>A0A183H6H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3085</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001954">
        <property type="protein sequence ID" value="VDO35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6H6"/>
    <dbReference type="WBParaSite" id="OFLC_0000308601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000308601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000308601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056939">
        <property type="entry name" value="Znf_RING_Vps8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23412">
        <property type="entry name" value="zf_RING_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps8 RING finger" evidence="2">
        <location>
            <begin position="4"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000308601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10700" checksum="F78B2C19788EDC9A" modified="2016-09-07" version="1">MRVTQNDDYITIFRCGHLYHRICLREANLSRCLRCEVERRRYRQKQQQMGSRADATNPSHSSSARNSRHLSIKPVRKVITSSPSMKVPQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6I1</accession>
    <name>A0A183H6I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-related protein 2/3 complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3093</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001960">
        <property type="protein sequence ID" value="VDO35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6I1"/>
    <dbReference type="WBParaSite" id="OFLC_0000309201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000309201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000309201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000309201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10575" checksum="E1446AF09DA86F01" modified="2016-09-07" version="1">MADDYEILDPTKADLKFDSDGAPDTPMLSSKQLSVSGAASSTVADKKIGEQGRKVILRKKDAEKIDDERSDGSRLSDLKREQGESDQFIIIYDPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6J0</accession>
    <name>A0A183H6J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001972">
        <property type="protein sequence ID" value="VDO35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6J0"/>
    <dbReference type="STRING" id="387005.A0A183H6J0"/>
    <dbReference type="WBParaSite" id="OFLC_0000310101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000310101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000310101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000310101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26375" checksum="7E15DB2626E06E4D" modified="2016-09-07" version="1">MQAQLTLPDSPDIPEEYHFSQRAFFVMDSAGSFSKSAVGKLRLNKKCKEERAENDYYKRNDQSLTRFVLSNGELCEKQLHLLRHPKTGNATLYAIGNERVEELLKFDDGLRSVLLGNNVISNGSLILLAPVNPTLLLLPYLRKYAKDDYVSLKDILVDDHFPSIKLLENIKAVKSSLRQTCRCKDSDYAVCGILEKNLPTDILKLVEINFIREGNENTSNKRILEASTRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H725</accession>
    <name>A0A183H725_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ALIX_LYPXL_bnd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3287</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002153">
        <property type="protein sequence ID" value="VDO35985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H725"/>
    <dbReference type="STRING" id="387005.A0A183H725"/>
    <dbReference type="WBParaSite" id="OFLC_0000328601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALIX V-shaped" evidence="2">
        <location>
            <begin position="68"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="57890" checksum="DC40AD5A1BBF7CB0" modified="2016-09-07" version="1">MTPRFKDMFSSLVPVQVHQATASFDARKSEVINVETGRLREHTQIMNGILASLNLPAALDDVTNHEVLPESIRQKSSKVKSQGGINAITQLIADLPHIRKRNQEILDETLRLLNEEKENDDRLRSQFKDKWTRMASDQLTAPLHQECGKYRGILHAAANADETVKQKLEENKEGIRLLSATEPELKYVLVYIASTAAIPCLDSSSTNKNSEAVVKLRGLMDVVQEIKVEREKLEKEFTNVHCDMSSIFLKALADNQIINEEEISTAKIAEIYGPLKKKVNETIKKQEDCLAEVELWNKKFSSEKASSNSAAERERILKILANGHDKFLEIKSNLDEGTKFYNDLTPLLLRLQQKVSDFCFARQTEKEDLMKQLQQNIISGSSNSNAPPRPPPPKASSNASATNNPFDIEAPIPPPRNISSLQGKVQSSGREGTQAPPLPSQNPHYQPQLCNPQQQQPFTPYAQPPYGYPSQQTPYLPQPQFNQNYTTPYPVAYPGTYPGAFNPPLHGNFKIQILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H726</accession>
    <name>A0A183H726_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Innexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002155">
        <property type="protein sequence ID" value="VDO35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H726"/>
    <dbReference type="STRING" id="387005.A0A183H726"/>
    <dbReference type="WBParaSite" id="OFLC_0000328701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29481" checksum="3D55AD9255F55345" modified="2016-09-07" version="1">YRYYVYTWITCFQFLTNATQITIYLIVFNVIIFMMLWSLVMSIITPTARVPIQYFVDKETDEKIKAVTPFKEDRYLPDTSTSEQVQNQSDILNSFAENKELRFVEVDNYNRLRALLTSIECIIRYFIRQQWTEQIVNFILVFLCVILFAIFGYYPLGELLVYHMRLAALNETTCEQAKPPNIRGDSNADYNMGTYRNLRAVFGWGLWAFPVDSHVGDGLHFPICYSERSAACSEIRYSIYREDEQNKNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H727</accession>
    <name>A0A183H727_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3289</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002157">
        <property type="protein sequence ID" value="VDO35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H727"/>
    <dbReference type="STRING" id="387005.A0A183H727"/>
    <dbReference type="WBParaSite" id="OFLC_0000328801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF295">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552417" evidence="2">
        <location>
            <begin position="24"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40603" checksum="FB9A69C4672FE11E" modified="2016-09-07" version="1">MSAHGKTLLCKTSLAWNLLLIFAQLEIFPLVNEISSRQSRSSLGGLTGHKGSVSLRINSKNHSLNRHDESSLVFITSHLLPNASNYEKRCLQYKNGQVCAFDDVARSSDENNIIWLGDFNWRVDQLTFQEMIMKLAELNPDDYMDKLINKFDQLKRAQRNGQAFMNYNEEKIHFAPTYRLMVGSSYYDQERVPSWCDRILFKGKSLRCERYESNRMVTLSDHFPVYAHFILSKLVSRQHSRWKVCFEKIPHWHNIVPFTCQFTYKDDFWNSGGSYRDWVAIYSADIPNSLQPLTWLYVVACYNVVIANRSVTIAEFPCLTAGHYRVGYFSAYKNCLQGLSDIFEVKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7S7</accession>
    <name>A0A183H7S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMARCD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3539</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002392">
        <property type="protein sequence ID" value="VDO36871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7S7"/>
    <dbReference type="STRING" id="387005.A0A183H7S7"/>
    <dbReference type="WBParaSite" id="OFLC_0000353801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000353801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000353801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000353801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="8782" checksum="F724DDE0A78DBC53" modified="2016-09-07" version="1">MTVQSNEQDDDSKQQGKAGNIGGPGAAKPAGRGMGPPMVGPPGPAPGLQGAVRGIGGPGMGMMQPQPMPGAPPFVVPQVFPPRGPMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7U7</accession>
    <name>A0A183H7U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase [NAD(P)H]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3557</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002415">
        <property type="protein sequence ID" value="VDO36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7U7"/>
    <dbReference type="STRING" id="387005.A0A183H7U7"/>
    <dbReference type="WBParaSite" id="OFLC_0000355801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000355801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000355801"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000355801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39069" checksum="E239C50DF078D696" modified="2016-09-07" version="1">MDTIMDPVTVDNEAGTSRTKNDDGCVIDSSEITNQAAISSYPVSNQWSESRTDWVTHGTYVPLRDRIKKRIAEGIPFFSLEFFPPKTRNSVANFFARLDRFREGNPLFVDIAWHFGSDPGNINSETSSTSVAAGCLDYCGIDTVLHITCCSYTKEQSIRHLEQSKALGLKNILALRGDLPRQDENPILYKYRALDLIRWIKEEYKDYFTIACSGYPAGHPEAPSYRADLLYLKAKVDAGADFIISQIIFDGQVFEKFLRDCREIGITVPIIPGILPIQSYESIRRIAELSQLIIPDSILASLEPIKNDDDAVRNFGIRYAVDLCQTLFTSGSATSIHLFTLNREASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8A8</accession>
    <name>A0A183H8A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3720</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002590">
        <property type="protein sequence ID" value="VDO37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8A8"/>
    <dbReference type="STRING" id="387005.A0A183H8A8"/>
    <dbReference type="WBParaSite" id="OFLC_0000371901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000371901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000371901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="5">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000371901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28789" checksum="A150901AD1E5BEF5" modified="2016-09-07" version="1">RAYLQPLRLLWVIAAEERLLSSIDADSEELVELEVEITFKGSKIIYPDVLNLRTPCIIPELSLLSKVQVGGQEYEKQIFDLRYESDKERLEEILKRQHGRMLVNYLGQKEQKIVIATIKQMCNTEDDPMLIPICEEDLLKATQNDQNFRQKFNFGLPETTNDIESIEKPNVSAFGSWIRNFQLDNGSIAAYDYAFSFVKDMLQKSPPRFARIQHDLLDAFLERSLFDQNDEWPIRSNVIPSELVISLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H932</accession>
    <name>A0A183H932_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oleoyl-[acyl-carrier-protein] hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3994</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002873">
        <property type="protein sequence ID" value="VDO38529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H932"/>
    <dbReference type="STRING" id="387005.A0A183H932"/>
    <dbReference type="WBParaSite" id="OFLC_0000399301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000399301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000399301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000399301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="690" mass="76419" checksum="069D4426BADB96F4" modified="2016-09-07" version="1">MYLIFWIIGDGYCRTEAVAAILLQRQSAARRIYATVVHAKSNTDGYKEQGITFPSGERQTALLEEVYREAGVDPNTVTYVESHGTGTKVGDPQEANAICQVFCQNRNSALLIGSVKSNMGHAEPASGLCSIAKVIIMMERGFIPPNLHYNEPNPYIPGLLDGRLQVVTEKTPFQRGLVGINSFGFGGSNTHIILRPANHAERKPAPTTFMKIIPYSGRTAEAVNNIFDSVLAYPENAYLQQLLANQANLPAKDTQYRGYMIINRDKIPHPPNAKRNPELPPLRDVQKIMITEPKQIYFIYSGMGSQWPGMVRQLMSIPAFDESLRSSSDAVADFGINVYEMLQSDDPSLYKNNTLNCMLAITAIQIALTDVLFLLGVTPDGIIGHSTGEMCCGYADGGLTREQTMHLAYHRGHTIVNANIKGGMAAVGLSWEEARKRCPEGVIPACHNAADSVTISGDAEKIEKFVEELNNEDIFGKIIDSSGIPFHSPAMLQVKDKMLKAMHTSIPDPKPRSSRWISTSIPESSWENELAQMCSADYHTNNAISPVLFYEALQKIPPNAVTIEIAPHCLMHPILRRSLQKTCTNVGLINMKEKDRELESFLQALGKIYQTGVTIHIEALYPAIQYPVPIGTPMISAMWRWDHSQDWPVIDGKMLSAAGGRQVPTSYCYTIDPFASDSKVYYLLLYETVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9A6</accession>
    <name>A0A183H9A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4068</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002948">
        <property type="protein sequence ID" value="VDO38756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9A6"/>
    <dbReference type="STRING" id="387005.A0A183H9A6"/>
    <dbReference type="WBParaSite" id="OFLC_0000406701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000406701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000406701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO38756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000406701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13567" checksum="B1F1E2310213F6DA" modified="2016-09-07" version="1">MGQFLGRSNGGTESNDMEVVADSTRATPSRKRRTTSHDEVETRKTKKISKLDTAKYIHKRLFIDGAKSDITIRALGRTWNLHKLYLEQCKFFDSLFRGHWKDSNNSVIQIDIVDPNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9I1</accession>
    <name>A0A183H9I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4143</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003034">
        <property type="protein sequence ID" value="VDO39071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9I1"/>
    <dbReference type="STRING" id="387005.A0A183H9I1"/>
    <dbReference type="WBParaSite" id="OFLC_0000414201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000414201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000414201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016011">
        <property type="term" value="C:dystroglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008465">
        <property type="entry name" value="DAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030398">
        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559:SF21">
        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05454">
        <property type="entry name" value="DAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51699">
        <property type="entry name" value="SEA_DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="3">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO39071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000414201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38623" checksum="302647F639EF2623" modified="2016-09-07" version="1">MMCEYPIPRKTFIDAEDGDTRSLSLSVCPIVADNNWLTLDRKNKQILHGISLNTGDFEFRLEARDSANQMTSAPFRVTVIPEPPTNHLFILDVDHSSERLAKDPDTLCAFAEKLANSLGDRFPKNLVIKKIEAIDSVRRQARVIFSNASLSHKFCQKKAIEAIKHVMLTRRRDRIRAEFVRAMDSRFHVRNVKLEFQGSCIEQLPTSRLPANVSLSTTINPTDHDTSSVHLWLPVALIAFLKFFLATLALVCCLVKRKRAKAVQSEYISKGLPVVFPEEIPQEDETAAVSTPMLVKEERPPLIISQHENPLYKPPPPLSTASSPRPRNAFTNQRQPPPYVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9X3</accession>
    <name>A0A183H9X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoporin NUP188 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003187">
        <property type="protein sequence ID" value="VDO39521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9X3"/>
    <dbReference type="STRING" id="387005.A0A183H9X3"/>
    <dbReference type="WBParaSite" id="OFLC_0000428401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000428401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000428401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056530">
        <property type="entry name" value="UBR4-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24079">
        <property type="entry name" value="UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR4-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000428401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34566" checksum="6DE3C17946374D3D" modified="2016-09-07" version="1">MPSFFFQTYALMETLLNDIESTRCHIGIISALMERYSWDSEPTIRPNMILKHMTLQSRFREVISIFLQDSTLATLYHSAEKLHNKLCEQTRQLEAFRAELLRYDIENGDETLSNKPGISNFRSNFDHCVGCVSALIVHCVALIQATCSDTNAMEEIIREDFIFGRLVSGCALGDPIARSVHSLIWNLSEMSKEATQKMCELVENGALPCYLLTKSIFENKFRFWEQKLRCLMRMAVFGNGNTEVDLHALAMFLKICSPYPANLKKAAVDSSGFSADKMRNDGTLAGKIFYYCISRLCSCKYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA21</accession>
    <name>A0A183HA21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Orfan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4333</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003243">
        <property type="protein sequence ID" value="VDO39669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA21"/>
    <dbReference type="WBParaSite" id="OFLC_0000433201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000433201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000433201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000433201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28712" checksum="A6CE7E5ED0F91AA2" modified="2016-09-07" version="1">MVIDNGTLYQTCNCCGHLCDEEIYQPDSGDMGTMLANVNQFWIITDISVTSIIFMLLIIFANFCIFIIIFDDLTYLCIFMWAYLAKLWDFDHKLPQRCKLKPVAQFLKKHKLLDHCVPRNLFIFTKNHSTSFLNTKSARENRYLTRLRRDYQNIRTQETLKKGFDTNKYIKAIITASTDTTGRTAIGGMIDLEIFSAYLYNSLNLFFCKSERMESLKDFVNLEIKLMSKYVFAIVVSVLWIKSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB94</accession>
    <name>A0A183HB94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003773">
        <property type="protein sequence ID" value="VDO40950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB94"/>
    <dbReference type="WBParaSite" id="OFLC_0000475501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000475501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000475501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000475501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6990" checksum="818A2DD781094AB8" modified="2016-09-07" version="1">MTNYLAKNLSRNSQPNPFPSSHPFQHLFQLMCSFLSLCRFVANLRVSRVDRSATVVGFRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBC4</accession>
    <name>A0A183HBC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4784</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003808">
        <property type="protein sequence ID" value="VDO41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBC4"/>
    <dbReference type="STRING" id="387005.A0A183HBC4"/>
    <dbReference type="WBParaSite" id="OFLC_0000478501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000478501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000478501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="67"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000478501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="44654" checksum="4C36E3219FC8CFC9" modified="2016-09-07" version="1">MVGSRKGQLLEEQENSVSVPAWQRASSVPAHKRPLIVSAKGASTAGSVSDEAFQQAFTEVPKCNVFSSKQLKDQISEACAVLENTDLDWSRRVTALKTLRAVIIGGGLDYSDFSEEVREMQAALLTSVKDLRSQLCREACVTIAFYCERLGLTMVNVIDAVMPTLISLMQNSAKVMATSAQLALQYVVKHVCSAKILPHLQTAMSSKSKEIRRNTASLFLMALTLWESRTVEKNMNIFLECIKTSINDADPETRKTGRGLFMQLDQEYKKQADMLYKTLDPSRQRTLSGFVSQSSSSQSIISERDALPISQRNAAYVLHKASPSYYSGRSTSDIDPGVVRRVTNHAIRTPSKWNGPLQQVNGTPSTTQMRTSAAQRLSSTSQKFVSSLRRAPPTPTNYARSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCV4</accession>
    <name>A0A183HCV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5318</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004508">
        <property type="protein sequence ID" value="VDO42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCV4"/>
    <dbReference type="STRING" id="387005.A0A183HCV4"/>
    <dbReference type="WBParaSite" id="OFLC_0000531501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000531501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000531501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000531501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12337" checksum="C2C6535BDDBC2D4B" modified="2016-09-07" version="1">MHLQGMDTRVSGQNPWDKAFLPRKWYNFDASFMKPFLTNANPTLLETMPSFMTPFAKIFTTKQQLAMYTRPANNGSISNQSTSNDNPFLRVRYYNSVDRIAMNNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD08</accession>
    <name>A0A183HD08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5375</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004581">
        <property type="protein sequence ID" value="VDO42937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD08"/>
    <dbReference type="STRING" id="387005.A0A183HD08"/>
    <dbReference type="WBParaSite" id="OFLC_0000536901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000536901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000536901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF29">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552485" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000536901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36557" checksum="39532415A5E2EB0B" modified="2016-09-07" version="1">MLLCWYVAIYCIVLSLEDDTQLTPETSITIDENAELILFGMRHGNRHPKKFLNKNSRIWGFEGVHELTQFGKREGFGFGKELREFVGPLVGNNYMQHEVTLYTSSANSCQMTLQVVMAGFYPPDTFAEWNHALEWSPVPYTINDLILETHSTLNCSATQRAWEPIIHDNLPELMDLTTTNAQLFDYIAKHTGWNRSIESASNLADNILEMNLYNASLPDWIERPTSEEFNKRSLKETIMMFLEKHSLTCVNYEPCRDITGGIWLNHILTILHNTAYGEQTQKLIGYVSVSFYDRKVTRIVGNCDKIQSRLLKSVQIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD86</accession>
    <name>A0A183HD86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plus3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5450</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004692">
        <property type="protein sequence ID" value="VDO43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD86"/>
    <dbReference type="STRING" id="387005.A0A183HD86"/>
    <dbReference type="WBParaSite" id="OFLC_0000544701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000544701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000544701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="170"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000544701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36576" checksum="11F4A593762F7159" modified="2016-09-07" version="1">FRHAIQKKIKAQKEDNAGLSKKEKKEKKRKEKEKKREKEAKKKMVESDVDERNAADGIPLHGGSVSDDKDNSDGYDEFQRPSEIQKKQKQKNAMADLVNRRKEKQEAAQKKKTQSHKSELDIDEVFGNDGSDDDYEKSSTSSSRSSSRSTSRSTSKSRTRSPSPEKKREVNCLADLSRIRLSRFKISRIVHAPFFNKTVIGCFVRIGIGKNKEGRSVYRAAQILDVVETAKVYQLENTRTNKGLKLKHGEEERVYRLEFVSNSEFTNQEFNKWYDAMKSNNLAILTIDQVEKKEVDIQKAVNYNYTDKDIELVSAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDW3</accession>
    <name>A0A183HDW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5676</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005006">
        <property type="protein sequence ID" value="VDO43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDW3"/>
    <dbReference type="WBParaSite" id="OFLC_0000567401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000567401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000567401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000567401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8990" checksum="1BCBF97C3EAD36B0" modified="2016-09-07" version="1">MRCDVWSCPYHLNFGRDGHVQRFDLMLMSVIFAWHLAKTLLLSWQKSSYEKAHDWNESDTRVLDSFTNAPTKVSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE58</accession>
    <name>A0A183HE58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5770</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005136">
        <property type="protein sequence ID" value="VDO44263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE58"/>
    <dbReference type="STRING" id="387005.A0A183HE58"/>
    <dbReference type="WBParaSite" id="OFLC_0000576901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000576901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000576901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO44263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000576901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9035" checksum="6AF963A8177780C5" modified="2016-09-07" version="1">MPDTDFIMKCRGLPWSCTEDDLREFFGEVARSITQIKLTKDRDGRASGEGFVIFNNREDYDFALTKDKKYIGKRYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEN6</accession>
    <name>A0A183HEN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5946</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005389">
        <property type="protein sequence ID" value="VDO44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEN6"/>
    <dbReference type="WBParaSite" id="OFLC_0000594701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000594701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000594701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552503" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000594701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21103" checksum="9C2B2C369184E7FC" modified="2016-09-07" version="1">MLNLVAVVLFVIFGAESFLDEENVVPDLAPHIDNPMEFEFVEDAHKKHYLKSLFTESFYEPDCDGKPSVMIKPIYFWPGQRVDLRCIMCRRAFTFNGLMKHWWFMEAKDVENALEDMKSLKNSPKWNQHLLTLSADYGDNRWRDFGAMPTGFDSGTNPRPQTVLIQRRGMLILLQVLFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HER2</accession>
    <name>A0A183HER2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF465 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5974</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005428">
        <property type="protein sequence ID" value="VDO44979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HER2"/>
    <dbReference type="WBParaSite" id="OFLC_0000597301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000597301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000597301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000597301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9230" checksum="E72DED880AD7EA3C" modified="2016-09-07" version="1">MYFLTSPIPMFVFLPNPVHNHIKDCCYKIYLRQQQLNESKDDYDTLPDVNHIPESFKESLKKQKMLYLEMLRQHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEU9</accession>
    <name>A0A183HEU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alba domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005479">
        <property type="protein sequence ID" value="VDO45109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEU9"/>
    <dbReference type="STRING" id="387005.A0A183HEU9"/>
    <dbReference type="WBParaSite" id="OFLC_0000601001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000601001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000601001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000601001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19366" checksum="DD6FF027A8ECABA7" modified="2016-09-07" version="1">MLHSRIPCKCLKDYFGGKKDMGKDSNSTRISIPDDAEFKLESFILPKCYYGDLKSVLIPKGLICDRIKCLAQEIFQTIGDKVMLLYPLVILCILKGSFRFFTELVEQLTHARATCRNLLEVEFIRVKSYTNVKRSDTLEIIGLLNTKQLENKNVVVKFYVYCPFISCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFD1</accession>
    <name>A0A183HFD1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit p66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6194</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005756">
        <property type="protein sequence ID" value="VDO45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFD1"/>
    <dbReference type="STRING" id="387005.A0A183HFD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000619201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000619201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000619201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000619201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10885" checksum="F416FECA30147CEA" modified="2016-09-07" version="1">FRYVSRLSIRNSASHVILGTQQYKPTEFATNITLNLDNAWGILRCIIDHCMNQPPGKYLLLKDPNKDKNDKSELSRYLYDLLMYDVALHHFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGD4</accession>
    <name>A0A183HGD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006288">
        <property type="protein sequence ID" value="VDO46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGD4"/>
    <dbReference type="STRING" id="387005.A0A183HGD4"/>
    <dbReference type="WBParaSite" id="OFLC_0000654501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000654501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000654501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000654501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7576" checksum="CE2988562D502E36" modified="2016-09-07" version="1">MESKTDIIFDDEEGELVNWKVTDGAYVSADSILLIYDTKNAEKKSLKTSTAGVVAIDTTIKKGKVSMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHY6</accession>
    <name>A0A183HHY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase, eukaryota, reverse transcriptase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007168">
        <property type="protein sequence ID" value="VDO49305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHY6"/>
    <dbReference type="STRING" id="387005.A0A183HHY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000709701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000709701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000709701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000709701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7851" checksum="CFB79C4FDABB1741" modified="2016-09-07" version="1">MALKVANFNFTMDIIVPQRRSVANSWQILISHLFGDASGPYIVGLVRCFNELFQKIWEIKIVLQLIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI59</accession>
    <name>A0A183HI59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7172</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007308">
        <property type="protein sequence ID" value="VDO49681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI59"/>
    <dbReference type="STRING" id="387005.A0A183HI59"/>
    <dbReference type="WBParaSite" id="OFLC_0000717001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000717001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000717001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000087">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO49681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000717001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26117" checksum="EF3E3C78EC552BC9" modified="2016-09-07" version="1">MSTFTAAVGNPSIVQFVQIDSLVVMKIVKHVDSEMYAGLNEVAGEACQGLLTGLVSSDDRRLEITNCFPTARAEPMLDGDEITQNNTFYEEQKQAEMLDMLRKFRDMNIDYELVGFYQAHPFGACFAQETIDSLIDYQASVPDGVVLIYDPVKTRQGQLSIRAYRLSAKALEMSLDGDWSPESTRANGLTYENMLEELSVVIKNSHLVNVMLAELALQGGYAVQRSSSHLELGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIF7</accession>
    <name>A0A183HIF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7269</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007464">
        <property type="protein sequence ID" value="VDO50135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIF7"/>
    <dbReference type="STRING" id="387005.A0A183HIF7"/>
    <dbReference type="WBParaSite" id="OFLC_0000726801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000726801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000726801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000726801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10066" checksum="2EFEF4B710C0388D" modified="2016-09-07" version="1">MYVNQQGMQQGKAKDLFIAITFGGDRVFGQRELICIIMMHCDLLEQISEGQILTKKMIKPGKMVIVGDIDEDDVIESINQLAKSMKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ25</accession>
    <name>A0A183HJ25_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7487</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01007853">
        <property type="protein sequence ID" value="VDO51202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ25"/>
    <dbReference type="STRING" id="387005.A0A183HJ25"/>
    <dbReference type="WBParaSite" id="OFLC_0000748601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000748601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000748601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin ubiquitin conjugating" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000748601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12940" checksum="305F4EE4F015F114" modified="2016-09-07" version="1">MTLTIEYPADYPLSVPLIEDEKAIVSRETRRKWLLQLTMFLTHQNGSIMDAVLMWAGNIERHMEGAEDCTICMMTVHSRTYQLPRVRCKQCKKRFHSDCLVSSSNLLFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ49</accession>
    <name>A0A183HJ49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7514</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007897">
        <property type="protein sequence ID" value="VDO51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ49"/>
    <dbReference type="STRING" id="387005.A0A183HJ49"/>
    <dbReference type="WBParaSite" id="OFLC_0000751001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000751001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000751001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000751001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26108" checksum="17FCAAA9BC4EB6C8" modified="2016-09-07" version="1">MNAGLRVGDKLLRVNKTDVVNVAVTSMQDARDVVELTILRDSHEIPSPYTACSGYTNSPNQSIDNSLISESIEASSSMTKETISTTIRRDMNGSPGFSVAGGTGDIIMISSIASGGAAERDGKLRVGDRVLSINGTNMRGARHDQAVALLTGHSGSDIYLVVQRDRGNQNINLASSSLSLSSTKTHTVERISPPKKYGFGDPSWDGKTEVSYYIISNNVYNISVLIIFLNKCWSAIFFVHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJK2</accession>
    <name>A0A183HJK2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Topo IIA-type catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7661</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008151">
        <property type="protein sequence ID" value="VDO52095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJK2"/>
    <dbReference type="STRING" id="387005.A0A183HJK2"/>
    <dbReference type="WBParaSite" id="OFLC_0000766301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000766301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000766301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF62">
        <property type="entry name" value="DNA TOPOISOMERASE 2 TOP-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO52095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000766301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26780" checksum="34F3A52FAF89F6DB" modified="2016-09-07" version="1">MNFKPDPVKKWKEERRKQELMMLGEVAQDEDEEEQESEENTHQSKELTNKLSDYDYLVGMAILKLSEEEKDKLLKESEAKLDELKALEEMTWADLWKNDLNTFLVELEKQEAKEQADLDIQIKNAAKKLQSDTGGVSRKKARIGLEVLPDPFAERVEPKIDAVKEKYEQKKAGEGRGRRRKVPVMKESKREGIDVRKFFNQDENNEQENLSGVKVKQSELSKVSYSVRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV2</accession>
    <name>A0A183HJV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRA1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008314">
        <property type="protein sequence ID" value="VDO52432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV2"/>
    <dbReference type="WBParaSite" id="OFLC_0000776301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18355" checksum="AC63ECDB08F938F3" modified="2016-09-07" version="1">MIVEKEVSPKDGNVEEVGGSNYYKMNKLPVDEIPKENLSEEESSDEVANAKNTSFVFQFRKILSTMRHTIRRIVNTLPVQDDNPSYGRGTLGIFLGVYISYMQNILLLALIFLRLPWIVGVLSLSLTAVAILLVFTAVLCYVLHSFHSFKISNLKFHFQISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK13</accession>
    <name>A0A183HK13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7822</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008415">
        <property type="protein sequence ID" value="VDO52671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK13"/>
    <dbReference type="STRING" id="387005.A0A183HK13"/>
    <dbReference type="WBParaSite" id="OFLC_0000782401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000782401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000782401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000782401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25052" checksum="DC5827601631A04E" modified="2016-09-07" version="1">MVVEQMILQQSTTVSAVQRTGRNSPTTLLGKTMEKMRAQKEAIAALSSSEHATREGAEFEIHCQKIATKEKTTLASSNGTCSIGQDNFSDEELLEYDSEYLSSDNYDEDEDDDNSDFMEDELVDLESVVLENFDNSMNKSLTEVQVLKLLKIFKERRQQKFFKEHPNILSPGRECDTPDENFDATVTKNKRKMVAVVKAGSSKSLIPVNMKERFARKELFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK28</accession>
    <name>A0A183HK28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7839</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008440">
        <property type="protein sequence ID" value="VDO52750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK28"/>
    <dbReference type="STRING" id="387005.A0A183HK28"/>
    <dbReference type="WBParaSite" id="OFLC_0000783901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000783901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000783901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000783901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14030" checksum="CD5A133DFEB4EBDE" modified="2016-09-07" version="1">MIRSKSLRSALRSSSTKNFNTRKTVHFADSFGLDLVHQNFYEADDFSIELEKFGAKFSPLTTKIIKRPQNVMLSLVKCQERTDAEISHLTRIQSVCLQSVKFVDMNIIGTINVSNIAYEKQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKF6</accession>
    <name>A0A183HKF6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7965</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008675">
        <property type="protein sequence ID" value="VDO53399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKF6"/>
    <dbReference type="STRING" id="387005.A0A183HKF6"/>
    <dbReference type="WBParaSite" id="OFLC_0000796701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000796701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000796701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO53399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000796701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="27049" checksum="31958EF3A741D1F5" modified="2016-09-07" version="1">MASPATPKHYTVHFFFMLFCRRNECRRYSILKFNGALKVDPSKWAAADYSIRMAREDNKEQSATNEICQEYGEGSEYGKALREEARRKKYGRQLQTYQHDNQPWMLSITDSSSKERKFRSIREGGAGEHADYWVFLKSGEEFHAYKVDEWYQFMPLSTHRTLDIDQAEERFRERNRVMNQFALKAQIQQQLKAMDEDGEQMIKTTKSLVSSLPQYFIFNLSFFFNCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKK7</accession>
    <name>A0A183HKK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8019</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008768">
        <property type="protein sequence ID" value="VDO53673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000801801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000801801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000801801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37446:SF1">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37446">
        <property type="entry name" value="CLAUDIN-LIKE IN CAENORHABDITIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000801801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18996" checksum="81819D92EB6B8D20" modified="2016-09-07" version="1">MCLSFAGQLLFGISMVIVLGLTIMSMFSPGIEQLEKVALNITEDLKHFTIPEGFNLLETLCRFASNTNVTINKTDSIDFCKKWFHELEDWEKIVVVFMCLAVITEVITICWTIITCCGCTCQKMCLQLSPILSLLVALFLAGGVTIFAMNNQTILDKIVITGNLSILSALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKR9</accession>
    <name>A0A183HKR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008867">
        <property type="protein sequence ID" value="VDO53943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKR9"/>
    <dbReference type="WBParaSite" id="OFLC_0000808001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000808001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000808001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000808001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6821" checksum="3310F5D8190AD748" modified="2016-09-07" version="1">MVAKNWRKGNAQKKLEYDIITIRNMNIVSSFGIPDVPVMIIDFTISILAKRFAIIFHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKU2</accession>
    <name>A0A183HKU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008904">
        <property type="protein sequence ID" value="VDO54020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKU2"/>
    <dbReference type="STRING" id="387005.A0A183HKU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000810301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000810301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000810301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000810301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24522" checksum="6379394B1928256B" modified="2016-09-07" version="1">MNNLQNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLIWSITDPMNAAAMNTQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLMQFLPIPKPQFELITCEPYGAVPTSPQKLGKSQMQGQIMQTTVKANRHGLQFAEKVKLSAFDIIQHLNVDSTLLKRPWSWSMLQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLS0</accession>
    <name>A0A183HLS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8431</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009526">
        <property type="protein sequence ID" value="VDO55612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLS0"/>
    <dbReference type="STRING" id="387005.A0A183HLS0"/>
    <dbReference type="WBParaSite" id="OFLC_0000843101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000843101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000843101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000843101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17392" checksum="F443467FF28F31C7" modified="2016-09-07" version="1">MLFQYLGSVQIFESLTKKKPEERDNWTRHCMYHICHQLGICEENSRPDERLRDKLGEVKIEDKDVELNVALHAFIILDKEGIRILERHPIHVISYASSGTEECTKGVFCFVSHIRELGRRCLVFMEPDKNVDFIMETILQIFRLNNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN87</accession>
    <name>A0A183HN87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuroblast differentiation-associated protein AHNAK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010542">
        <property type="protein sequence ID" value="VDO58154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN87"/>
    <dbReference type="STRING" id="387005.A0A183HN87"/>
    <dbReference type="WBParaSite" id="OFLC_0000894801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000894801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000894801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000894801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13374" checksum="7BDD88F4039A9F8B" modified="2016-09-07" version="1">MDRYGKISNGMELTRMEWTGMERTRMEWTGMEWIERNGLERNGLEWKGNEWNGMEWNGLKWIRNEKNVMESDGMELNVLESSRTELNGMASNGMETKGMELNGLKCYGIKGNGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNB0</accession>
    <name>A0A183HNB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010572">
        <property type="protein sequence ID" value="VDO58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNB0"/>
    <dbReference type="STRING" id="387005.A0A183HNB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000897101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000897101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000897101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000897101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12162" checksum="FDB65185B19FC23A" modified="2016-09-07" version="1">MNLFVVRSENIFSTEWKNCWMSAKYRLDHLSTIGNNTYHFWKCAPKHAHLLKQPTRLLLWKAENKQLETAGVMSVYGNSTWTTVRRGWLMIAVFNDAVAIVEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNQ3</accession>
    <name>A0A183HNQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spermatogenesis-associated protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9113</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010848">
        <property type="protein sequence ID" value="VDO58757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNQ3"/>
    <dbReference type="STRING" id="387005.A0A183HNQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000911401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000911401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000911401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO58757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000911401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20068" checksum="D054E5AAF42A86C9" modified="2016-09-07" version="1">MILRNRLREMDNAALIIQRNWKRFKVEQKYLQFRRAIITLQAHFRGACARKQYEELKKQNDSKNRKPNFTITKVVRKKELASFNLNDPESLAQFAGSDEDEEALSEASTSNLDEEDELEDDRADLETELEATFILEDKKLKLVDAPIFKRRISSASTGTTKKVLFFVFIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNW3</accession>
    <name>A0A183HNW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Laminin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010971">
        <property type="protein sequence ID" value="VDO59016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNW3"/>
    <dbReference type="WBParaSite" id="OFLC_0000917401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000917401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000917401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000917401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10097" checksum="3934E04525B60066" modified="2016-09-07" version="1">MDGVLRSAQRDYNSESTNASETTNVIVQIQLIDYIDQDLRLPHGQTCVCPDEFSCSYLGTSVPRCYMSFTVNTEIRLSLETGNVVQNCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP23</accession>
    <name>A0A183HP23_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9234</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011117">
        <property type="protein sequence ID" value="VDO59293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP23"/>
    <dbReference type="STRING" id="387005.A0A183HP23"/>
    <dbReference type="WBParaSite" id="OFLC_0000923401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000923401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000923401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO59293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000923401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="21101" checksum="436749D43F93C03C" modified="2016-09-07" version="1">MNEKLQPESRAQFGLLEKKKDYVQRARDYNYKKRKLQRLRQKALSRNPDEFHFHMIRSHVGEDGVHHENTPEPDEDTLLQKKLKDLEDLKYLKHRLNVENQKIEKLRATLHFADTVATKNTHTIFVDTEKEAKNFDPVKYFDTPKEVLNRRYNRPRISTLQSSSIINAKGKNDVKVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP28</accession>
    <name>A0A183HP28_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9240</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01011132">
        <property type="protein sequence ID" value="VDO59327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP28"/>
    <dbReference type="STRING" id="387005.A0A183HP28"/>
    <dbReference type="WBParaSite" id="OFLC_0000923901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000923901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000923901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO59327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000923901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11623" checksum="9FDDD20332BA86DD" modified="2016-09-07" version="1">MSNLYEIESGNLTFSRLRSFPTTPLVKLGSCFNNVQDYLKRFQGIPDLLELDHLTVSGDVWFGKDVTLKGTVIIIANHGDRIDIPPGTILENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQR2</accession>
    <name>A0A183HQR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012480">
        <property type="protein sequence ID" value="VDO63645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQR2"/>
    <dbReference type="STRING" id="387005.A0A183HQR2"/>
    <dbReference type="WBParaSite" id="OFLC_0000982301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000982301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000982301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000982301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12767" checksum="1DC0A7D74BA69DAF" modified="2016-09-07" version="1">MLLKNLKKKKKANLRKNIAFVRFSGNNNKIVTNVMECEDTLMTSDNRERPSRFFKTPRIGSRRIRNRLVQKGGICNISLVNVPKQRRKYFRFFIFFQLFSCPFISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQZ4</accession>
    <name>A0A183HQZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3336 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9907</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012655">
        <property type="protein sequence ID" value="VDO64354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQZ4"/>
    <dbReference type="STRING" id="387005.A0A183HQZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000990501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000990501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000990501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO64354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000990501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="24221" checksum="BF6BB871BD200398" modified="2016-09-07" version="1">MFHFIDKVRKDWKEEPERLWRKKELKPFTDYIELSKFALSENDLKDEDGNLSLEKCKAVQGGRSLIEATPEAKSRKYNAELGKDRYNIELWLKFLAVQDEVFLAQESVEGRKKTREERLTNRELLERKMSILDKAISLNFNCVKLKLERLKIGMHLWEENVFIRETRDVEFKHVNDPEMWKGILDLLESDTRRFNLANQVCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR04</accession>
    <name>A0A183HR04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS9916</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012677">
        <property type="protein sequence ID" value="VDO64428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR04"/>
    <dbReference type="STRING" id="387005.A0A183HR04"/>
    <dbReference type="WBParaSite" id="OFLC_0000991501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000991501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000991501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF279">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN UNC-105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO64428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000991501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15197" checksum="8DFFFE25E51DBEA9" modified="2016-09-07" version="1">VIRLCGCANPAYPIPKTAKSCKVSDYIARECIKNATYHFSRLISEGNLTDCVCHQSCSEVNYEVTYSAARWPSGTTKVMECDNVDDLCMERYRRNAAMIQVFYEELNYETLTETPAYTVNSLLLSLFNSSLILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRI1</accession>
    <name>A0A183HRI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10095</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013106">
        <property type="protein sequence ID" value="VDO65782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRI1"/>
    <dbReference type="STRING" id="387005.A0A183HRI1"/>
    <dbReference type="WBParaSite" id="OFLC_0001009201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001009201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001009201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001009201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7661" checksum="980E7ECB5E1F4760" modified="2016-09-07" version="1">MINELGKVCMIDANDSTTDLDFYVDKPFHNLAYDHYCDTKVARRIGEYFVKQIQKLQEVRNVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRN5</accession>
    <name>A0A183HRN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA topoisomerase</fullName>
            <ecNumber evidence="1">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01013235">
        <property type="protein sequence ID" value="VDO66211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRN5"/>
    <dbReference type="STRING" id="387005.A0A183HRN5"/>
    <dbReference type="WBParaSite" id="OFLC_0001014601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001014601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001014601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001014601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12909" checksum="60E6D77FE5FC806E" modified="2016-09-07" version="1">MRALFVAEKNDAAKSIAAILSRGTSTRRDGRSRFNKIYQFTANIGQNAGCQVAMTSVSGHLLQHEFPASFKNWTETPIKVLFDVNIQKNIIPGMEDVRTTLIEEIRKSDASFNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS32</accession>
    <name>A0A183HS32_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10295</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013557">
        <property type="protein sequence ID" value="VDO67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS32"/>
    <dbReference type="STRING" id="387005.A0A183HS32"/>
    <dbReference type="WBParaSite" id="OFLC_0001029301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001029301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001029301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001029301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15346" checksum="EFF96EE1104949FD" modified="2016-09-07" version="1">MMTARRYDTRTTIFSPEGRLYQVEYAMEAISHAGTCLGILASDGILIAAEKRNVHKLLDDEVLTEKIYRLADNIACTVAGITADANILINHLRFWAADYKYSYGEHIPVEQLVQMLCNEKQRYTQVGGKFTVYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSF2</accession>
    <name>A0A183HSF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013855">
        <property type="protein sequence ID" value="VDO68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSF2"/>
    <dbReference type="STRING" id="387005.A0A183HSF2"/>
    <dbReference type="WBParaSite" id="OFLC_0001041301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001041301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001041301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042410">
        <property type="entry name" value="WBSCR13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321:SF1">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001041301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20308" checksum="73EF3F738CE47F43" modified="2016-09-07" version="1">MNKDNMGHNSGIYSFAFDQSSTRCVTASKDGTWKIYNTDVRYSQGEEPKIIASGEFEVLKNAHPESVKVAMSPSGNSFAISASRHICLYSTLQPEKEFKIILDVHDNPINGLRMSPCGKMIASCGDRYIRIFHNVAEFYSNVVMLEKTVQETREDSRRRRLEEQLHEARREFSPFAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSW3</accession>
    <name>A0A183HSW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDCD2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014242">
        <property type="protein sequence ID" value="VDO69648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSW3"/>
    <dbReference type="STRING" id="387005.A0A183HSW3"/>
    <dbReference type="WBParaSite" id="OFLC_0001057501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001057501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001057501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001057501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14099" checksum="CD04A4BDC4E1D03A" modified="2016-09-07" version="1">MIPCDLGNGDLEDLEDFVDKDMAFKYFNKVVALNPEQVLRYSRGGEPLLATDHAPLAETVPPCSLCGSERQFELQLMPHLLALIGVDDLGKSIDWATLMLYTCKQNCHIPNDGYAEEYVHKQDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTD0</accession>
    <name>A0A183HTD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gelsolin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10739</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014658">
        <property type="protein sequence ID" value="VDO70940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTD0"/>
    <dbReference type="STRING" id="387005.A0A183HTD0"/>
    <dbReference type="WBParaSite" id="OFLC_0001074201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001074201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001074201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO70940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001074201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16739" checksum="902ABA919B31A064" modified="2016-09-07" version="1">MNKKDRKGRSEIESCTELRTPEEFWMALYGQPNKPEDPIVEHVDANFVRERRRLYQVQIGMGFLELPQIELKHSILKQDMLDTKCAYILDCTSDIFLWVGRKANRLVKMAGQKMVVELHEMLERPNYTIISRETEGEESTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU17</accession>
    <name>A0A183HU17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10987</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015297">
        <property type="protein sequence ID" value="VDO72893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU17"/>
    <dbReference type="STRING" id="387005.A0A183HU17"/>
    <dbReference type="WBParaSite" id="OFLC_0001097901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001097901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001097901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001097901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18053" checksum="1CFFF9D0869AEA77" modified="2016-09-07" version="1">MIYHFLRQNRFLATAAVFEKEMHQKIIPLEELKKENATTFCFQFVGDNITLSDSIPTETEQEMKESHSTIIRSSETNDIDSKFMSYLGKNNNDKESNAKTIERQQISHSESNTTLKSASSESEISRDGNETSNRYFHLPNFKEKFSISVILLFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUC5</accession>
    <name>A0A183HUC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11088</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015558">
        <property type="protein sequence ID" value="VDO73724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUC5"/>
    <dbReference type="STRING" id="387005.A0A183HUC5"/>
    <dbReference type="WBParaSite" id="OFLC_0001108701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001108701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001108701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF244">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001108701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9344" checksum="932520052923B598" modified="2016-09-07" version="1">MGAKLTDKKVEDLKLLVRRKIGAIAVPDVIQIAPGLPKTRSGKVTRRILRKIAEGDQAADLGDTTTLIDETVIAHLWDGRAETRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUL2</accession>
    <name>A0A183HUL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gelsolin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015800">
        <property type="protein sequence ID" value="VDO74416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUL2"/>
    <dbReference type="STRING" id="387005.A0A183HUL2"/>
    <dbReference type="WBParaSite" id="OFLC_0001117401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001117401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001117401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001117401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19358" checksum="209A6A19CA9CEE51" modified="2016-09-07" version="1">MDEKLWHSVLQKGVIKPDQLIKRRGKLGLVKCGNMFVLRDWFNEMKEKSIQVGKTVGNLNNFILEPFCDHSDSDEMYIAIFSRRESDVILFYEHGGIDVGDIDAKARKLYIPVDIDRQSDSVSDDDIESVIGPIESQKLSYVMHNFEFFSGLIFKFIFIFFKIIHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUM6</accession>
    <name>A0A183HUM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015841">
        <property type="protein sequence ID" value="VDO74548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUM6"/>
    <dbReference type="STRING" id="387005.A0A183HUM6"/>
    <dbReference type="WBParaSite" id="OFLC_0001118801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001118801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001118801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001118801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8854" checksum="93113ED347B1CE58" modified="2016-09-07" version="1">MDICESALAQRRSAQLPKLKKISNKPRPLSNDFSVFFLFAKISFLIDTRYEMNDFEFTYSDCDTHAAELAELYTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWD9</accession>
    <name>A0A183HWD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C2H2_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017542">
        <property type="protein sequence ID" value="VDO79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWD9"/>
    <dbReference type="WBParaSite" id="OFLC_0001180101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001180101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001180101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001180101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8832" checksum="87CFADE1C55A0A41" modified="2016-09-07" version="1">MAERRRGLHSKDCAPAMLRRMRPFPPSVCIECGISIVTDADTTSQENFVDHVSQDHQREATCQYYSFPGVHLFEVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWL0</accession>
    <name>A0A183HWL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017709">
        <property type="protein sequence ID" value="VDO79957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWL0"/>
    <dbReference type="WBParaSite" id="OFLC_0001187201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001187201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001187201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001187201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4374" checksum="B055D16CBFB4A4BE" modified="2016-09-07" version="1">MEDKLCDKGMSQWVTLPISTLQQLVLALLIDKCPPQMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWL2</accession>
    <name>A0A183HWL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11871</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017714">
        <property type="protein sequence ID" value="VDO79978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWL2"/>
    <dbReference type="WBParaSite" id="OFLC_0001187401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001187401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001187401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001187401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4771" checksum="C9966D9F6CF8A62C" modified="2016-09-07" version="1">MMIVQLMVIYWRLILVLMMDYSRLFLRPTFSPLSFNYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWW7</accession>
    <name>A0A183HWW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017971">
        <property type="protein sequence ID" value="VDO80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWW7"/>
    <dbReference type="STRING" id="387005.A0A183HWW7"/>
    <dbReference type="WBParaSite" id="OFLC_0001197901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001197901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001197901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001197901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11614" checksum="AE0BE5657022AF50" modified="2016-09-07" version="1">MENRGFGNVEELARAAPEEIGQLAGGIPPRTQQQPQGSLITAVPQQILGSSSLSSSLPSSIKPSTTATTLPQQTTVEGGGARATVRVRQRPHIPPKPQMDAVRYSMANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX10</accession>
    <name>A0A183HX10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CG16972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12018</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018103">
        <property type="protein sequence ID" value="VDO81173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX10"/>
    <dbReference type="STRING" id="387005.A0A183HX10"/>
    <dbReference type="WBParaSite" id="OFLC_0001202201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001202201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001202201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001202201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7329" checksum="B891DA2D781D0D2F" modified="2016-09-07" version="1">QQQQQEKQQQQEQQESQGRQQEQQHQAEQQQQDEEEEVVLNSNTNSETILSPMPPPPVFEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXN4</accession>
    <name>A0A183HXN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12244</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018769">
        <property type="protein sequence ID" value="VDO83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXN4"/>
    <dbReference type="STRING" id="387005.A0A183HXN4"/>
    <dbReference type="WBParaSite" id="OFLC_0001224701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001224701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001224701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001224701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10301" checksum="47FC3BC95D2073D0" modified="2016-09-07" version="1">GITFRKYEKEGGIRKGHVITIEPGFYAEGKWGIRIENCYEVVAADKVRSNAENFLTFSPLTLVPIQKSLVDKTLLSLEEKMWISELGDVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZP7</accession>
    <name>A0A183HZP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12959</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039991">
        <property type="protein sequence ID" value="VDP12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZP7"/>
    <dbReference type="STRING" id="387005.A0A183HZP7"/>
    <dbReference type="WBParaSite" id="OFLC_0001296001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001296001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001296001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001296001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22087" checksum="8C92100CEF602CC7" modified="2016-09-07" version="1">MAAWKYWVSNGIVTGSNYTNHSGCRPYPFPPCEHHNNKTHYEPCKHDLYPTPKCDKKCNKEYGKSYKADKYYGKETYTVENDVKSIQKEIMTRGPVEVSFDVYTDFLNYAGGIYKHVAGSMGGGHAVKMLGWGIDQGVPYWLAANSWNTDWGEDGYFRIIRGIDECGIESGIVAGIPKRQVKSKFRGATEFLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZY0</accession>
    <name>A0A183HZY0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13042</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040022">
        <property type="protein sequence ID" value="VDP12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZY0"/>
    <dbReference type="STRING" id="387005.A0A183HZY0"/>
    <dbReference type="WBParaSite" id="OFLC_0001304301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001304301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001304301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001304301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53139" checksum="B4E946AD32B42214" modified="2016-09-07" version="1">MILQEENMENSNGIMQTNIMNGGMNRVPESTEASSHNTALSFVSGPTFTTGSVPSVTLQGSPTAYIPIQVPGVIETAFTQTPAFAAPLIYPSALTAAYITGPTPPASPCTFLSAAAPITAVCHCIYAQPCALHHRPITYASHSLSSLGTVPATLSQSHSHTLPATIANNVASARVSSLPPTLTLPSLRSSMMRLKRSGEQLATNHLPVTDPDSSANIRLQKIRRVEPGAEATTSYLTSQRHIEAQGDERSTVDNRSSLNSTICCDCRSRTTYQCPYQSCPYHHHHICPRHPMCFCQRNESGTSYRRETDMNPVHDLLLSSRIAQIERQQQANNLWFQRHSLASSNLIGVDIVPRRLASQPIVFLPRHHQPIMELAMVLLQPHDPTVILGSNVPTSNDPLPIGATVEQINRFSTTYKYVKENDIPENEQERCTVCLNDFETDEEVRALRCNHVFHVVCIDRWLVYNKKCPVCRLDLDKTNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I084</accession>
    <name>A0A183I084_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13146</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040064">
        <property type="protein sequence ID" value="VDP13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I084"/>
    <dbReference type="STRING" id="387005.A0A183I084"/>
    <dbReference type="WBParaSite" id="OFLC_0001314701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001314701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001314701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001314701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24592" checksum="D80DCD02DF04D5CA" modified="2016-09-07" version="1">MSHERSRGNLSPLAYVLDTSSNSSSQLSEGAGQNTLSSSSSSSPSLAAALRNFDIGGSTARQHARDVFGYSQDDSSTHMESYMEYLALLNHRHAQEPMDESNGTGSSSADVATNESLSLLTNTTNSLSFGMVSSINDENGDHTGDGNNHLTEAENNNDITSSSSTQMNDFSDVEFALIRDLYSPSASDPGSSSERRGSSRQFSRNFFGIYFSYVIRGSFVCLVVVSSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2G4</accession>
    <name>A0A183I2G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13926</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040475">
        <property type="protein sequence ID" value="VDP15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2G4"/>
    <dbReference type="STRING" id="387005.A0A183I2G4"/>
    <dbReference type="WBParaSite" id="OFLC_0001392701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001392701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001392701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001392701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29877" checksum="6035986C7EBB1FD7" modified="2016-09-07" version="1">MQYFNTEVTLISNGAVYAQVILTIRSTCSLDFTAYPNDIQSCLLTMFTPLPLSRCCLLLQLKFSRSTSLTQKPDMFGSLMNELRTIRSGEFEITNLSASLLFILPFGKITANESADRPEMMRSVIRFEIKFRRIIYYYSVTIALPLFCLATITFMVGTIVSASNTIVWLLLCFAGQILNYTQMLNKLPPDQQNTPFCAKMATIMLAETMALIIYRAAITYKYRHSINEKGMFRCSRMQKIEKTLRILFILHTFLNAVLLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2X2</accession>
    <name>A0A183I2X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14084</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040586">
        <property type="protein sequence ID" value="VDP15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2X2"/>
    <dbReference type="WBParaSite" id="OFLC_0001409201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001409201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001409201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552748" evidence="2">
        <location>
            <begin position="21"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001409201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="674" mass="75229" checksum="52B9B2CA1D8E7615" modified="2016-09-07" version="1">MIFSASTMVSLLMLCVSTHCCRNMKKKENPYGEIATTPIADASTSMAVSRNRIDGSRFHHPSRLSCPNLSLHERSVHRLSAPLPNSSVTKRALPKLPELSAQFENKNLGAIYSTVDHSTSVLANASFLYGEGPANPTYESIDVDPLYSKLGNGGPSVKRYDYPIFTSENRPSITADDVLYQSASHIYAGVSEDPYSSITSHTGGETNYDVGYSHVRENMNTEPSRNYLANAQVEGRTLDHLYSQIRREPSISRTINSSTYRPLPSNEFGVEYISSGSDKTSREPSYRYITVRESIDAIRQRLNELNPSSNTHQSVVIDGCGPIREHYYSSIGGSDYETLQISATSTNQPSYDSQNIPSTSRVNHDEQPKTISSASICENIPPKPPISPIPLRFTAINDDNNLQLSLSGTNMDQAINNSDNISNISEKIRRLRTNFFDQELKLLKDLNGSSSTDLRFGQLLGTIDQHETSKCVNSSDTNRNLDPQHYADQTLGNESSTNFDHAYSHLPKLTVDRSYAHNAQNVIRTMPFSIANRQKIIHQEECENIARNSRPHSFHEASVFGTEQSFKEDMTFQQEGSNEERQCFIPERHDRFDKQTGNNSSTSFTRASKDVHNSVVHSFRSSSFPRTYPANRLVVSLNKVSNSAEEDMKAQSCSHPRSTIELSCEEGDIDLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Z4</accession>
    <name>A0A183I3Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14456</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040870">
        <property type="protein sequence ID" value="VDP17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Z4"/>
    <dbReference type="STRING" id="387005.A0A183I3Z4"/>
    <dbReference type="WBParaSite" id="OFLC_0001446401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001446401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001446401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001446401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28552" checksum="3107C79BCC10F577" modified="2016-09-07" version="1">MCALQLFSIFQQPGHSVIASSSASLLAVLPEPKNASRISRNMNIFSSSSTYSIGNAKVSDVSTSILITTFFQCHNFFSSHFFALFLILYCSSSNAGCFIRLHSTVELRDDVKIKGNVSAFVPHPETIVQCCDASTSSTLSGAIDDNQALCMIYSRDVAHLGGTVSNAAKAVENMVDVSVDKVLGPNIHATLLKNLHNKSLAEATLSHLANIPKNKEAVSMVARRKHQITYLASVAVAREEQLAEQWSVNRHNKRTSARKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5C0</accession>
    <name>A0A183I5C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14930</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041372">
        <property type="protein sequence ID" value="VDP19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5C0"/>
    <dbReference type="STRING" id="387005.A0A183I5C0"/>
    <dbReference type="WBParaSite" id="OFLC_0001494301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001494301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001494301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001494301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36110" checksum="5B7AF6A4D4C0CD4D" modified="2016-09-07" version="1">MQYFFTVQLAFFDISMLLASLASFGSIGLIACGLLGFSAKFPSENVQAVMIGQAVAEILSSLLSIICQSLAANALMNGRLFFVIALIWTILSIFFYELLIRSKETESLLVEESIRIDQSSSQRLLDSLDNSFETDGSPLHLRSVEAHSLWDDAKQVWKKTKTEWMAGFIISFGTMTAFPAISSLVQTTAKNVIWKNYFSSLACFLLFSCGDALGRLFVNFFKLSRKALIILSFLRLLAIPVFFFCNINPRYHSVTLFHNDEIFILTMILFSISNGFLFTTTTINATRKVREELRELAGSIFGFMAVISTVFGSLIGLLLVKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6B3</accession>
    <name>A0A183I6B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clathrin_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041866">
        <property type="protein sequence ID" value="VDP21121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6B3"/>
    <dbReference type="STRING" id="387005.A0A183I6B3"/>
    <dbReference type="WBParaSite" id="OFLC_0001528601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001528601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001528601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001528601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18855" checksum="1D9A51DD2A2A62D9" modified="2016-09-07" version="1">MQQYEDDIRMNIQHSRYQSQDTGADRLNSVGVGEFCELEMGSASSGNESDVYLASFAKDLEFNFDGREINDMLANFNVTDGENTDILHDQPFSDGVKDEFLQLPTEFNEISGGHNWLDVEQFLISEGVDLSSSSQSSNVSAVSVQQPLSLANDGVSFCDFSSSSTSHQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6L8</accession>
    <name>A0A183I6L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3475 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042038">
        <property type="protein sequence ID" value="VDP21595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6L8"/>
    <dbReference type="STRING" id="387005.A0A183I6L8"/>
    <dbReference type="WBParaSite" id="OFLC_0001539101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001539101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001539101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001539101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16382" checksum="D2C0D81F7D228867" modified="2016-09-07" version="1">MVSTQNRPIPAPRISLTNRKPAIPNRILKSEVVPNSLISLPNSTKLVSNSLLHQTVLPLQNLSSKRNLRRVRCERSFGSFDKCSSVDDLENSAVAIINSWIGNKTDDRDKLLLSAWAEVIVCKKDYGKLWVIVEESALAGWATNDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6S1</accession>
    <name>A0A183I6S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15434</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042136">
        <property type="protein sequence ID" value="VDP21873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I6S1"/>
    <dbReference type="WBParaSite" id="OFLC_0001544401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001544401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001544401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="384"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP21873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001544401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="72330" checksum="7FAA5EFBB85DF4F3" modified="2016-09-07" version="1">MDCSHSMLERFLPLEMIRNDSQFYDSVRSVLNNNQFILSEILELDISYNKLKDIPNFDDFYHLKRLNLEYNRIRSIPDEAMTSLNYLEELNLSNNQISEISEYAFKNLTFLRTLNLGGNNLKTLPSSLHILNLRELHLDDNWIEKFLPELSNFSSLKTLSLANNRISYIQPRSLIEYCKLENLNLARNPLFEVPRQILRQVALTLVKLNLSSTPIATIRSGDFTNLLAIQEIDLSYAKITKIEENSFCNLPKLLKLHLNGNPELEHISSSAFQLLPSLLLIHLHNCSLSGLDXXXXGAFQLLPSLLLIHLHNCSLSGLDDLNLQSLPSLQHLTFYGNPSLCNCNLTWIQHLRHIVMDGKEIRCISKNKRYRNLHTFEILEKCPPRIIGLPTAITVMERKRLFLTCDAIGNPKPAIQWRDPTDAEISNERFLIFPKINQNQSGNYRCLAYSEAGLDEAKIFVNVIPRLKLQMLSINSTMAVISWHGKLPYNTTRLRVRFRYNSTEFVRNAEVNETRITVRFFREMFLDTIELCLLDGTTELVCDYFDNRKDSSEGNFIYLKFFVVSFCFILCAYNINFKFKRIDREVEMMRMTVNLERNPTFYNSSTLAVQILTRPKFKYSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Y1</accession>
    <name>A0A183I6Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UCH_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15493</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042247">
        <property type="protein sequence ID" value="VDP22171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Y1"/>
    <dbReference type="STRING" id="387005.A0A183I6Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0001550401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001550401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001550401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAN2 UCH" evidence="1">
        <location>
            <begin position="79"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001550401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34815" checksum="FF3FE3AADB01C551" modified="2016-09-07" version="1">MRMVQFVGYAHNPRADTALRGFNVCPYTSSAHDKYFSSVIKNDEIFHAPKFYLRMQGKLTSQAEEIDFKQYNRTEFNTLENNVETSPACMLLLAMYHLMNVRTVFLSHFCYLEDCISCEINLLFRLLTDRPVPSMLSAKNFMKTFRSVDDGKKWADAVVNANLAHSVHLFMQTFSKIVDKELSETTAGVALRKELEISFTLNNHCIRCSEHYQSALSQLYISIAYPANNEKIGFCTLLEKTLNCPEQNEAICQKCGKLARFASTRRVRLLPNILALDVTASTETEQAFWISHIQVMKILWFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7F7</accession>
    <name>A0A183I7F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15669</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042585">
        <property type="protein sequence ID" value="VDP23159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7F7"/>
    <dbReference type="STRING" id="387005.A0A183I7F7"/>
    <dbReference type="WBParaSite" id="OFLC_0001568201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001568201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001568201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP23159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001568201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14848" checksum="CD81504781390724" modified="2016-09-07" version="1">MLSSSLSSSSSSSSTTSSSTITSYMSPIITTTIAPSTMTTTTTTTSTTTTTTTMATRTERAPILIEQLPYPSMFHATNIPLLYDHIALTINAWQTLGKIRRPRTAFTTEQLIELERNFAQTRYLSRPRRYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7L4</accession>
    <name>A0A183I7L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small integral membrane protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15727</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042723">
        <property type="protein sequence ID" value="VDP23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7L4"/>
    <dbReference type="STRING" id="387005.A0A183I7L4"/>
    <dbReference type="WBParaSite" id="OFLC_0001573901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001573901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001573901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037659">
        <property type="entry name" value="SMIM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28622">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28622:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001573901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8570" checksum="F2892F026F5660AE" modified="2016-09-07" version="1">MLSELIISSTLLLNAFTVINFKLSKANHFGSFVIIEGEDRSVTDRIRDFLRLLRSFRVFIALWNIFIIFLMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7V1</accession>
    <name>A0A183I7V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042947">
        <property type="protein sequence ID" value="VDP24045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7V1"/>
    <dbReference type="WBParaSite" id="OFLC_0001582601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001582601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001582601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001582601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17367" checksum="0A24FB830D87F30E" modified="2016-09-07" version="1">MISDIIDRQLYLYNDNDMIIDIIARQLYLYNDNDMVILDNDMISDIIDRQLYLYNDNDMVILDNDMISDIIDRQLYLYNDNDIVILDNDMISGIIARQLHFYNDNDIVILDNDMISDIIDRQLYFYNDNDMVILDNDMITDIIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8D2</accession>
    <name>A0A183I8D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15994</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043527">
        <property type="protein sequence ID" value="VDP25764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8D2"/>
    <dbReference type="WBParaSite" id="OFLC_0001600701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001600701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001600701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001600701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10600" checksum="9EE755DF6728AC18" modified="2016-09-07" version="1">MIFGNLLKQFFFLEQERTELANALRIYLKNVVNQLADGATVQRISEKFGARHVRYRTFGFRPDFFATTADAVTTECVLLDAAIHPASEALFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8H7</accession>
    <name>A0A183I8H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS16039</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043735">
        <property type="protein sequence ID" value="VDP26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8H7"/>
    <dbReference type="WBParaSite" id="OFLC_0001605201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001605201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001605201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF88">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001605201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8310" checksum="A4AFA60C3B710514" modified="2016-09-07" version="1">MDNSTIIDLSIDFLQLFISIAACISPLLACATALGILLWCGLRFGSILTATPILVLAIGVDDAFLMINHWQQIYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UKD0</accession>
    <name>A0A3P7UKD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002054">
        <property type="protein sequence ID" value="VDO35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H6S4"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="126" mass="14727" checksum="1D4DD627B8D628BA" modified="2026-01-28" version="1">MSKQIGLFEKLANAAGHMYRYQLTQLPRRKALWKDCWHKELKPPTLDDWPAIKKDFKQMMDAIVGRSYTQWTIMDTLVRTCVAVEIICWFFVGEAIGRRSFAGYIVPATYVDKKLMNMAKHHKDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VM21</accession>
    <name>A0A3P7VM21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001329">
        <property type="protein sequence ID" value="VDO32673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H4D6"/>
    <dbReference type="OrthoDB" id="5822988at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902562">
        <property type="term" value="C:H4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52052">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="177" mass="21145" checksum="D603170F5575742E" modified="2026-01-28" version="1">MGKPLRIAISLNTLHNNSDRATTRAAAIRFNDEYDEFDHAHAYIARRTLTRVPLLAENNAYRVIFQQEKGYSELLRKSSQSNENSRVECPRFRKVPDLEPLRATPRHNVEICTDEAYLKRHEKYEKQEKLIKRRDRIRQREEQYRLHLMKLEKPNASSEPKIESIEVVERKPRLRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W1E7</accession>
    <name>A0A3P7W1E7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003707">
        <property type="protein sequence ID" value="VDO40807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W1E7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048311">
        <property type="term" value="P:mitochondrion distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051946">
        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF12">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN MILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="354" mass="40499" checksum="3DEE118504ACBD54" modified="2019-02-13" version="1">MQSANLKKVFSELEENEQLHISKWTKQLDTANEKICNLQLLLAEKSEECEIQNSEMERLLREVSTRSSHEKMLANEVNDLHQQWQDALQMHNELMVQVADLQERYTEVLAMLHDAEEELRTYRQNQSAYRTSTPDSLYDSLASEIEASDSGFYSSINNPKILIRKQDVQQSKMDMNHLSDKLEVIKDNQTLNEMTTRSVATVTDPLPSNRCRQNSHSDDNVVDVPNHILAKLGRRSHLPLLSLTPVEKVSTSSTDNQPESSSTSKSEIKHFEVDSNNAKINTSQQRRQFFDEIYPACFMYDLSRISGFISGSLSRTASTDSLASYEGPKMGEPGRPGTRDLDWSIRKLNIRRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X9D8</accession>
    <name>A0A3P7X9D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000232">
        <property type="protein sequence ID" value="VDO26548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZI5"/>
    <dbReference type="OrthoDB" id="5830779at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF42">
        <property type="entry name" value="PROTEIN CBR-NPAX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="177" mass="20042" checksum="1FC0DA505199E165" modified="2026-01-28" version="1">MALEQNTVASSTTLNHEIQIHNAQTDCTSLLMATGYDSAFCFTSALSCIVPTELQRYLLPFTLPPTPCTINSSRQSGSMKKKKKKEVQSKNSCKLIATTTPQATSSKNKLGRLYNPGRPLAMEERQKILQLYKKGHRISHIARIIGVTHSCVSKIMTRFDIRHLKRKMLKKKDFKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y4I2</accession>
    <name>A0A3P7Y4I2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002110">
        <property type="protein sequence ID" value="VDO35802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y4I2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="171"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="400"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO35802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="514" mass="57330" checksum="A455E74EB2BCB58A" modified="2019-02-13" version="1">MQYLAVEEVSGEIRVLRELDHERRTSYHLIAVPVDNRSNGETVHVVVNVIDENDNTPTFPVSSIDVAISEFAALNSEISIPPAVDNDSPPLSVIKYHILSGNVNNAFRLSSKRINSMLYVDLVVNGQLDREYRGQYELLIEALDGGDPPNSGKMLVNVTVLDANDNAPEFSQNKYYASIPWNAPMDYVVATVHAVDADLDENARVAYSIAKSRADLKLPFQIDGETGVVRVSDSKLLVSDAVYQLLIVASDHGLPQPLESTTFLTVTVQSSNQSQLNFDIFWLTNSNKPQVYENITIGHVVARIAVQNVPQESELLVNGCDALCIKETDSSGVYLILACGSFDREQKSEYNLFFTMKSHGRQLLKIPVFFEVLDVNDNAPKFEKSIVQVRFNRSTLHHKLVQIQASDPDHGENGRIHYTLSGTNLFEIESETGILNVHENFDCSPEEHRFRVRAEDSGIPPLSSTVDVIAQVIDSSDRPPIFSKPLYDITVKEDAEPGTCLLKVRYHFPFIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z3D3</accession>
    <name>A0A3P7Z3D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017425">
        <property type="protein sequence ID" value="VDO78974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HW94"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="116" mass="13104" checksum="901D7270A5C96307" modified="2026-01-28" version="1">MIVIGGWINWTFSGFVTTRVPFPLTLRFKPMLQRGIELASLDAAWVSSASWYFLNVFGLRAIYTLVLGEGNAADQSRMMEEQMSGPAMATPQDPKQAFKAEWEALQMTTHQFILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C4Z0</accession>
    <name>A0A3P8C4Z0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040203">
        <property type="protein sequence ID" value="VDP13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8C4Z0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21583" checksum="26E2C20A172398B2" modified="2019-02-13" version="1">MQITQLIKGIFLKRYDPTIEDSYKKEIVVDGTTCTLEVLDTAGTIREIFRKSIYFICYLNSRISEFTKNQLLQEQFTAMRDLYMKNGDGFIVVYSITDASSLINTVEIFQSLLRVRQKYHIENQGKCPVIYKFQFPLILVGNKCDDIINREVSRSVGERYAARYNSTFCEASAKNNIHVIEVFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EXA6</accession>
    <name>A0A3P8EXA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039911">
        <property type="protein sequence ID" value="VDP11976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817353at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="208" mass="21716" checksum="71CD1EA4A1C29EBC" modified="2026-01-28" version="1">MSHIVYYVLISASIFFTIAALPVGVSNKKDSKFCCECTVEDKKTTETVTGLGTGIISTINVLTPSLRGCGGLTPAVTGGTGGGFISTGGAGLINTYIGGLGTGFMMPSVQIPAPQMQIIPRQQHLLYNLQTMQLPFFNMQQSKVSTQCCMPCPDGSGFCCCSPGATTTVPRDSGSLPPPHYPAGAGIPIKNTSLLVSIITMLALENIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXS2</accession>
    <name>A0A183GXS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TORC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS32</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000007">
        <property type="protein sequence ID" value="VDO24269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXS2"/>
    <dbReference type="STRING" id="387005.A0A183GXS2"/>
    <dbReference type="WBParaSite" id="OFLC_0000003101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000003101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000003101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000003101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8013" checksum="506D7E1568BB8844" modified="2016-09-07" version="1">MPSSRNVTVLAGNSTNNSYCTLGGSDLQNADMIDLDDGSGPADPLLEKQQPQLLHADFYNDFDDFSIMLKFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXX9</accession>
    <name>A0A183GXX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small integral membrane protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS89</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000021">
        <property type="protein sequence ID" value="VDO24497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000008801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000008801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000008801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000008801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11651" checksum="963DDCED3C038D9B" modified="2016-09-07" version="1">MELTEKYESEEAEQLVNELLSIMDMKTRQPTVSTMGEGSKAREHVPNWAFIVIIVSILLSALAFYIGTCINKKTSWRPFSNGKPKTAGKRRLWGAGFSGGIWGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZE2</accession>
    <name>A0A183GZE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helitron_like_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000211">
        <property type="protein sequence ID" value="VDO26371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZE2"/>
    <dbReference type="STRING" id="387005.A0A183GZE2"/>
    <dbReference type="WBParaSite" id="OFLC_0000060101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000060101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000060101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000060101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7799" checksum="D39AF5D6275F6EBC" modified="2016-09-07" version="1">MEWQKSELPHAHILIWLYDKISSNEIDDVISTEIPDPDVDKDLYEVVTKNMIHGLCDTLNPKSPYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZF3</accession>
    <name>A0A183GZF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000215">
        <property type="protein sequence ID" value="VDO26404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000061201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000061201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000061201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000061201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15132" checksum="5A7F273302BA36C4" modified="2016-09-07" version="1">MIQIVSPFQDCPAYRVDGLEDVSDAVNSRKLNKSTKKSEAIHTSIPIPLFSFSSDNNTTLSQKSYHPSGWAMSGFGDILVRDVCNSFPIDFRLRNGRLNRELLESSKINRIVQIFQIFCPTFVRTDVNFIAWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H070</accession>
    <name>A0A183H070_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DAGKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS881</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000357">
        <property type="protein sequence ID" value="VDO27433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H070"/>
    <dbReference type="STRING" id="387005.A0A183H070"/>
    <dbReference type="WBParaSite" id="OFLC_0000087901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000087901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000087901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000087901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31401" checksum="704307599498C9C1" modified="2016-09-07" version="1">MYKAIDRSEMTHHRPLSLPLPQSLMFIGCMNPRNSLVILMCSLTGVITTMLKKHLLTDSIVANEPSDMVMVADIRSTDGKYHRVIFDRSRKFIKFTLTEGAEEKQQSMLKDLNELICVRGTPIIMRRGLPFDLNKNAKQVDTPNHLYFYFAEKRRKRHWRIRTVIALFTTTTDKKLWLSVLDSSLHELEQRPKALLIFVNPFGGKGKAKKIYSEQVAKILEMADIHCDVVMTQRANHAFDYLKQLDSLQWKKIDGVVSVGGDGLFNECLSAIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H163</accession>
    <name>A0A183H163_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1223</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01000544">
        <property type="protein sequence ID" value="VDO28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H163"/>
    <dbReference type="STRING" id="387005.A0A183H163"/>
    <dbReference type="WBParaSite" id="OFLC_0000122201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000122201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000122201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000122201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="510" mass="59259" checksum="665F027EC1CD4AAE" modified="2016-09-07" version="1">MPRDSIIQHTLPCPPLQQEEIDQLIHGMLNTSGVPEHPLSELITLEKLFFICHKTVDLLRECGTLEYIHDPNGVAIFGDLHGSLYDLFRGIKDAGWPTERTLIFLGDYIDRGKYSLVTLLFLFLLKLRYPKRMYMLRGNHETMSQCYANEEDERGLIRNVCVYFYNIQYCYPNADRDLILFNINFVFDHLPLAAILSDQVLLCHGGISQFAKSRNDIAQIPRPLTWLAPETNVFHISIMTDILWSDPSKEITSKYSPSGRGASYFFNRRALKEKLREFNCRALIRGHEANTSGFVRVFNGLCYTVHSSPAAGDEYYVAAILLLDFNDSTKLLEGRAVYHTTKGNLDHLRGDLVTNFEEVRHLYPLEPADSNASQCWSCMRFMEGVSETIFKWQRCLSHFDYFMIMQEYRTGEHYLPFEEGFFDEMDSITSEDNLHKLYRAAALRYPIFLNLLISENLSQRTLTSLNIMKYFLKDLIKINGTEQPEEVPEYDFKFVLPPSNERWPFLEIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1P8</accession>
    <name>A0A183H1P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IntS14_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000654">
        <property type="protein sequence ID" value="VDO29426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1P8"/>
    <dbReference type="STRING" id="387005.A0A183H1P8"/>
    <dbReference type="WBParaSite" id="OFLC_0000140701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000140701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000140701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="1">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000140701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50273" checksum="968CF4880C73DD42" modified="2016-09-07" version="1">MTVYLAVDSSLSMRLPVDENNEMSRRMIACQLVLQTIKKVQALDMDRKIRLIDFSHNSKIMPCDVRNIEDAERNLNCISVSASADLISLFLLVKMENDDETSILLVFTDACTFTPEEVNLTHLPNCTVKFVCVLDEASTDENQIARLWAISLQTEGFKEEFEFEDSRPWMPYFMSDYDTVDSYSDALANDLCPVPTFLLKCGLLKAYFKTLPSIDNDDWSTVIEIIGFVPVNSLTNMPTTRHHFVISQLNSEDVLNILCSALRLEESVAICRVNKNLYGTLCHVSAKEEDPSVYRLSIVLFPPGSMPVSWLPPFTTMSSQSVVDAGNEEQPFCIRNDGLSRPSYSSIQRTCWYEVHGLQSDIQKIARLLKKIPDRTFLFYSELNRIHAYCCALGAEDILEKLIQVLHEESSAQSPLIIKHSVYANEKLRMYGLKNSAEIQPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H251</accession>
    <name>A0A183H251_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1560</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000760">
        <property type="protein sequence ID" value="VDO29981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H251"/>
    <dbReference type="STRING" id="387005.A0A183H251"/>
    <dbReference type="WBParaSite" id="OFLC_0000156001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000156001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000156001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048711">
        <property type="entry name" value="WHD_Rv2258c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581">
        <property type="entry name" value="PROTEIN CBG10435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21320">
        <property type="entry name" value="WHD_Rv2258c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase Rv2258c-like winged HTH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000156001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34236" checksum="23553EBCA311FC33" modified="2016-09-07" version="1">MLSLGLVMGYELQLFNTLAAVSSENEPATSIMIAEKANMRERYVREWLCLMACGKLIEVDESGEKFWISEDRIEDLCGDKPNPLLVFQQFILMCAKAYPSVIGLFKKDGPLGMDNKMFDEFDKRMAAFSEATHKDAIINKFVPATGMQSKLEEGGIQALDVGCGRGMHIAELGSHFPKCFFTGIDLSLDAVVGANKKRDEANAGLDNVSYMQMNGQMMKDEWTEKFDWVMMFDACHDQTRPDRCLKEIYRVLKPDGLFSMIEIDGTSNVYKDKEMDGSTFMYGVSLSHCLPVGMNSEGKHCFTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2B0</accession>
    <name>A0A183H2B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoLip_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000801">
        <property type="protein sequence ID" value="VDO30195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2B0"/>
    <dbReference type="WBParaSite" id="OFLC_0000161901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000161901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000161901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000161901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25489" checksum="C4ABB1BB09C1D4B4" modified="2016-09-07" version="1">MEAEGWESNFPIAIGGSLSWMELSVIEYETVSLILSPVLAILQEEMIDFDRFQIIQLKFVLFPQNLHLIWQKKLALGFDTVEFDLFQYQYIANFFSWLTMIGLSVPAFYSWMNSAISADASWESIDYLLIGMSIMFMPNYKYSEMWLQLSLTAYDFMVLEQAKFWAASIGQWFVQNMAHATIFALIGKIVMFGALVRYFIEIKQRRKSDYSDLSLTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2X1</accession>
    <name>A0A183H2X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1831</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000943">
        <property type="protein sequence ID" value="VDO30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2X1"/>
    <dbReference type="STRING" id="387005.A0A183H2X1"/>
    <dbReference type="WBParaSite" id="OFLC_0000183001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000183001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000183001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000183001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36246" checksum="BB1E2F0C9EE8082A" modified="2016-09-07" version="1">MGLGTAEVEMTLNPNNLSLSGLGPSSIEQILRLRQERNQRVPKCARCRNHGTVSALKGHKRYCKWKDCMCAKCTLIAERQRVMAAQVALRRQQSQDEKEAKDLEILLGAERAGKLLKFMRQGETTTNESTTKESLLGSVATLEEDDKTKSSQIIDSPSTSLIKPKVSSSNTTQENFSLSIIPHQRSKNNDKADPESNKSYSPIDVTKSTEPQQPIYSSQWSNPLNFCTFQPLPSLPYRSQPFGQAVFPFGVGCYPINPTMMYTKSPFPSIPEGGAIAQITHSCDSSTSQSTAHFSYTSLAPLTSVQANPLDYRQNVKSSNSNEDLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3I0</accession>
    <name>A0A183H3I0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2040</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001098">
        <property type="protein sequence ID" value="VDO31669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3I0"/>
    <dbReference type="WBParaSite" id="OFLC_0000203901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000203901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000203901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF48">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552359" evidence="5">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000203901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16324" checksum="AC63D611BFCD15A3" modified="2016-09-07" version="1">MISVLILCLFLDFVANNTPKFAEMISTRSTAVKGILLCGDTPVIDTKVRLFRKTSNNFGEVLSTKQTASEGHFEIEGDTVGRADQDIEPMIRFCGIKNFSVIQISYRAFAINYPKEYVTIGRVPRKLFEIGKLNLQVCLFIEISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H481</accession>
    <name>A0A183H481_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vac14_Fab1_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2291</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001286">
        <property type="protein sequence ID" value="VDO32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H481"/>
    <dbReference type="STRING" id="387005.A0A183H481"/>
    <dbReference type="WBParaSite" id="OFLC_0000229001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000229001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000229001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000229001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="751" mass="83838" checksum="EC3EFBCF3982FD8B" modified="2016-09-07" version="1">MKHEAVRILDLSVADPTRTPKFEDLVAFFHRKLNLQDATEGAVDFLTDEVKKKKETFADEVFHISALYLYANLQVACSLQPLSLTESDVFSRTSDYPVISRYLLSISEEHRGILNLFLEVVLKAIEAQPANFLIEMACLFLHNGSGNLSHNYRATTVAWLERHLNSNSHITICAKLSELYSLILTDMERKKCLEQCFKQFDSDKLSVQIPWLCAYLATQPSVNFTAEEINGIKVRLVKIIETLSGQQNFEAACGSLAELLRRTVFGLNGIEKITLVSSVSDNQFCSLCELLGKIAASRKDILTLKMKESAVKCLGFLSLHSSSTVLYEKILAQLFACGEVAAQPELQFIVGNALFDAAFGESSPSRRNIFVETEKYFLARNLSITKLDNIEKKIANLLEILMNVKLHQANRHLRQAALIWLFTLMKRCAVTKLNCIMDSLGSIQHAFINGLTETNEFSQEVASEGLGVIFELGSEEQKKIMVEELVNTLSTGRKRLDPIAPNTRLFAKGELGTTPTGSESARSHIQGAAFGFNIIMQQAESVMEPYLAQLVPKLYRYRYDPDLKVQGAMRSIWQAVTVSKKSVTEEYADAIFNELLLTLTDPQWRTRESSCLALADLLSGYCTDKITERFGQLFEILYRVQDDVKESVRIAAGRALSSLIKITVRKCSSVNGAKATQLLGMVLPIIIEKGVGSSIKSNKMLSLNIIMDIVKEAGLTLQEHINIIVPCLLDSLSEEESTFLNYLAARSSLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4C3</accession>
    <name>A0A183H4C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHD finger protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2338</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001322">
        <property type="protein sequence ID" value="VDO32651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4C3"/>
    <dbReference type="STRING" id="387005.A0A183H4C3"/>
    <dbReference type="WBParaSite" id="OFLC_0000233201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000233201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000233201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21085">
        <property type="entry name" value="WH_NTD_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000233201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42907" checksum="7BCCCCCC43508A44" modified="2016-09-07" version="1">MDIVLAGDESSSSKLSEAPTSILTSTTVVDEISDESTKLSLSVPDSESVPHEGTSKSGGKEVRMVKSSSTRVITADTTHMHIEPSHIIEYEWPPKSGERYFIQEQIAELLDVKSFKRKYPELSRHTIEINEREYLLANYKLATAINEHQMHGLTALRAIEVHELMASDYPAIYSEYQRAAADKVKLQMAEEQKRLDAIKLDTKKMDELRKSAIRSAFEFNSEMNAIKRTERRYFWDLQTSIIQSSKNRWKRMPPEYTRPGPYPAALIHGQYQHFYKKFTPNELRRLPLSTVLDYDYLLPPKRPVSPLPVIVHEEEVTATTISDSNDAGQHDNQLELPPPVLLPSNYNDDIKTKLDKMDSQIYWSEESTRFVIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4N8</accession>
    <name>A0A183H4N8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS2448</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001411">
        <property type="protein sequence ID" value="VDO33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="OFLC_0000244701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000244701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000244701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000684">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000244701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40849" checksum="C6D42D0C46A7EA6E" modified="2016-09-07" version="1">MQTVEFAVPSDSTDELSTVEYLGGGSFGNVIKVTNFICADGQRRVVAIKKLYEPFRDEKAALRVFREIRLLQMMVHENIVRLLDLYTPDNSLSTLSIVYIVTEYAGNSLYEILKRERETGLQILTPEHHKFIIYQLLRALKYIHSANVMHRDLKPGNLAVTDECDLSVLDFGLARSLNADDTVLSAYVITRWYRSPEVMYWKICSYDKQADVWSVGCILAELSLGRPLFPGEDSMAQYRLIAELCGSPDPELLAKLASNEAILNVITKLGVYSRKSFSDYFPKTFSKHLVDFLDRILVLDPEKRMTVTDALSHPYLEEYSMPEDEPVADGPFILDEGSNGRTVAEWKGLRLPVFVQENLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H509</accession>
    <name>A0A183H509_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2569</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001502">
        <property type="protein sequence ID" value="VDO33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="OFLC_0000256801"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OGT"/>
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        <property type="entry name" value="TPR_rpt"/>
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        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000256801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16468" checksum="04747A45448C891A" modified="2016-09-07" version="1">MAPPLMKSTGKSTRKENRWQIKTFVMISLLVCYIICAGCYLKAIETQPQFAVAWSNLGCVFNAQGEIWLAIHHFEKAVQLDPNFLDAYINLGNVLKEARIFDSFIKHNFFVLEIDFDGNIKYEIEHGYNDFCIVFMWCKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Q2</accession>
    <name>A0A183H5Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001715">
        <property type="protein sequence ID" value="VDO34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Q2"/>
    <dbReference type="WBParaSite" id="OFLC_0000281101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000281101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000281101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000281101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8072" checksum="678A6A047187D005" modified="2016-09-07" version="1">MTHYNEDTSTHTGATHIFFPNRGTPLGGTSGNVPTPNHDTTHCMPDSQSEGERKRQVGDDRQKRSERCNAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H607</accession>
    <name>A0A183H607_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2918</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001810">
        <property type="protein sequence ID" value="VDO34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H607"/>
    <dbReference type="STRING" id="387005.A0A183H607"/>
    <dbReference type="WBParaSite" id="OFLC_0000291701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000291701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000291701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21762">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000291701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="847" mass="93555" checksum="04F025F8F7B28555" modified="2016-09-07" version="1">FPVSRDTSPDRNIPPPPPPLFVPPPPSVSSAEPIRRSQSPNPALMKLGGKVTVDRDELMRSIRQGVKLRKTVTNDKSSAIINDDDSGVRSPGRSSPSTSNYEDDVYGSQSLSDISSIGTSRFSSLSNIPPERSMDMYFASPAPVIPETDIRIDATSSSLRNSSPAKSPSNRLPLINVTVDVTNYDDAEVVNESETIILETPKKRKADECYSSPIPSRKQIEAEIPIGSARDRIKMFGDTERETSHSPARNSSKSRKSDVEVGNNGFGISRIRKLFADKTAEQPPASAPTRHTEEHEQTVTIGSGESSIRKMVRKFSTDEDSNKASQPVWCQKKVEKAVEEEEKIPLAKQKTSTIKNSAKKKTNTKGSKLRRKSSTKNEPPTAMSKKTYAAATKAEEVSPELSHEVEEAAEDGDVTSKWAVPKVNISKFRERFENPPETCLTSEEPIKPGRVKKPSWVKDNESESPLPLPISHKTEEAPRPPWKKVGPTESVEVKNSVETTTRKQKSSDREEPAVNVPTRTSSADITKKVASGFKKDKAPSISSSLATKSSKKEVVPVKEEEITVPTREGVGPYRYTRKISATDKKPAVKKNSTGSKETSTFSGGNLLNSVSKPFGTNFSTTGQTTTIGADDMKEESKAAPPNRHLVSKNKVQSKATADRECDEKLGDKTTTAPTAKKTIEKSDGIHYANIGIALTKIYAVPIDNIAWNNQSNGDHSMSTSFLSNGNCYGSYGSLKQNNRRCLSPTTKCKYSDNLIKQQQSPQLQSSTMPREWNGMFGRAHRVIVGVSESRSKISKGFQQRSFGDNDNIPIVYQQQQERQQQNHLFHHNYRFQIDLENDQQPVRIVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H652</accession>
    <name>A0A183H652_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2963</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001849">
        <property type="protein sequence ID" value="VDO34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H652"/>
    <dbReference type="STRING" id="387005.A0A183H652"/>
    <dbReference type="WBParaSite" id="OFLC_0000296201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000296201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000296201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000296201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="935" mass="110151" checksum="D610EF6512F91C71" modified="2016-09-07" version="1">MLKEQIRKLEQEIEKLRTENRIITEQEEKTRDALTKETNRIHLLQKELEETKAEIGELLKKIKQLEQELESSFRGTRKDELDETERVSDKISLAPSGPTVSDTEIIEIKIREINDKWKLEFDKLLGEKDELERKIRDLEDQIIQKNREIERQESEIAELKRKHQEEIDRLKSEISQLHDKHQSDLDDEKEQYNKNLESIKIVEDELRNKLADAERKLAEAQNRENQLERDKAELKEKYEQALAQIQKLKDDLEDARQEAENEIQKWKTEVYTVRSELKAVETANNALKTQLTAANERAETLNKTVNDQNAKIRDLNTQIRRLEEEVSDLKSAAVTRESDLESALGRLRSVEDQYATLQSEHAKTRNELEILQREFDLLKSTNTNQESELERLRNKIQQYEVTIKEQKNALDHLKAERERLQNIYRDKVKQSDHLNQLVQSFDAKMNKMRQNLRDISDKLVAAETERNTLRSEVTKLQQELQFGKDQMVRRTDEYQSSLEDLANAHRAAEDGRLNALQELESTKYELADLKSRFENTEQRLTSLQQDYNKVENERDIMADSLKRFYSVTTHAVTLHKVKEDVDRDQMIETEIPRSIPFPATIEYTSTGGRTGATTINIGETLDINQLENTLQTLISRIERLERERNEYREAFDRLKKKTTDTHTTIHKQETRYKTIEENLTDIEEEKRALEIRLASAKQLLRSQEEALKQRDEERRQLKAKIVAADLEARGKDAQLRHLNEQLKNLRNDLETAQADLRSLREREEQWDGNRFQLESKLRDKEGETQRLILLQTNLESEKQSLNERIKELSGQLQLSDIKCTDMREDMERLKRELSKAESVEIELRKTSDYQSRTINEYQILRDQITSAQNDLANANYQKQQLEHELTTARGELRDFKQRMRDLNGRASDLQRQLQDASAEKNRLEERLVTLEKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H694</accession>
    <name>A0A183H694_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enhancer of polycomb-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001882">
        <property type="protein sequence ID" value="VDO34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H694"/>
    <dbReference type="WBParaSite" id="OFLC_0000300401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000300401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000300401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000300401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20193" checksum="EF321130BD16E4AA" modified="2016-09-07" version="1">MTRKKRQIELTNGWESKRRSIRLSKSTRVGNSRVCREVSPEIRSLQEGRIGLDSVAPLLSRRAKILAMKTYYQYSNDEKCDISDKSDENSFLESDCDEPHNYHRFYDHHRAPFHVKRHYEDYEDKLVPSSSFTLSIPTTKHFCIRSVLKSYRLRKSIATISVLLLNREGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Q3</accession>
    <name>A0A183H7Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002367">
        <property type="protein sequence ID" value="VDO36790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Q3"/>
    <dbReference type="STRING" id="387005.A0A183H7Q3"/>
    <dbReference type="WBParaSite" id="OFLC_0000351401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000351401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000351401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000351401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9596" checksum="368397C85C2D83E3" modified="2016-09-07" version="1">MLREVTFHNDGSALLTLTDHKCSAISWEPFEMLGQCIVPQTDYSLNLATSDSEIFVLGRSVLLSSLSLLMVPYAVSMAFISRNSVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7U3</accession>
    <name>A0A183H7U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MitMem_reg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3556</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002414">
        <property type="protein sequence ID" value="VDO36950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7U3"/>
    <dbReference type="STRING" id="387005.A0A183H7U3"/>
    <dbReference type="WBParaSite" id="OFLC_0000355401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000355401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000355401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit RPN11 C-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO36950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000355401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20730" checksum="5A789E207109EDE6" modified="2016-09-07" version="1">VVIDAFRTVGSNILEFSFLDDAQKTLAPTQESRQTTSNLGYLVKHSVIDQLHGLGKSYYSITINFKLTVKEQQMLQSLQMKNWAEGLRLNNFEATTINNLRNMQEMVKMIKLYKKEFCVLPKKPHDEEGTEKSKSLSKAETEAKQVGHFNPKRHLANIANDLMKENILHELRSMIDASAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7X2</accession>
    <name>A0A183H7X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein yippee-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002444">
        <property type="protein sequence ID" value="VDO37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7X2"/>
    <dbReference type="WBParaSite" id="OFLC_0000358301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000358301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000358301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000358301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19860" checksum="F61D2100584ACD26" modified="2016-09-07" version="1">MERLSTFMDLFEYISKFGEMDEKTARIYFNQVVKNEQSFLHTVVVNGYCVSLYECKCCLSRFKDLIDFGSGTFCKTKGEKFTGPTSLKILTYCCYKAAFIGTPVYSCRNIFFITSMIAIKQPFGCFIPERRDHYLSTIISTAQHILECSFLLHLFRNCTFFVCKFLNLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7X4</accession>
    <name>A0A183H7X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3586</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002444">
        <property type="protein sequence ID" value="VDO37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7X4"/>
    <dbReference type="WBParaSite" id="OFLC_0000358501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000358501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000358501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000358501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19405" checksum="AE3C2F38DDBEA096" modified="2016-09-07" version="1">MSSSRKQTSNMRSAKIIVPVLILSCISAVNQKAKRLKLKLKEKPFRAELTLSRDVNLQVQEKEFANVDRNSFVIIDLFSSKNKCGTSILAHVDAYNDTTVLKMFAKKQTLKIAYVLRVYNLKLIRHQDLSITQLLFASAISERALNNASSVFKNSVVFFKFKLTSCSTPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H889</accession>
    <name>A0A183H889_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3701</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002569">
        <property type="protein sequence ID" value="VDO37475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H889"/>
    <dbReference type="WBParaSite" id="OFLC_0000370001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000370001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000370001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000370001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3331" checksum="20EF50ADE2CD829D" modified="2016-09-07" version="1">MSGKQEGQNIGLLSKGRAMTPVNKNPFGGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H893</accession>
    <name>A0A183H893_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3705</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002572">
        <property type="protein sequence ID" value="VDO37486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H893"/>
    <dbReference type="STRING" id="387005.A0A183H893"/>
    <dbReference type="WBParaSite" id="OFLC_0000370401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000370401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000370401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000019">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="98"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000370401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="53149" checksum="E14FC34C1956F5B6" modified="2016-09-07" version="1">MFCNRVENGLDGLRVALEKHIARQGEAALDKIADVAVNDPKQYVSTILKIYRSYHSLVTYSLKREPAFVQALDKGCASFINRNNITRKTNVNFKNPSKSPELLARYCDILLKESPKNPKENELEKFLHQIIIILKYIENKDRFEIFYMDLSAERLLNDLSASDEAESNMISKLKQISESEYTYKLQQMLNDNRLSKNITERYKQHLASKNMNLGLDFSIMVIGSGVWPFSQSPIFNIPVQLTKSMESFNEFYQTQHKDRKLTWLLAQCRCELSAHGFQRKYTFTATTAQMAVLMMYNENTEMTLQQICDNTKLRHEIVTQIVQALVKMELLSIVGPKIDIDANTPLSTVLRLNSDFSNEELKIDLSKAITPVAERQKTAEADGFMEKDRIELVQAAIVRIMKIRKKMKHSELIKEVFEQLGSRFTPNVKMFKKSIDFLIDRDYLQRMENEKNVYEYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9C4</accession>
    <name>A0A183H9C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carn_acyltransf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4086</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002971">
        <property type="protein sequence ID" value="VDO38822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9C4"/>
    <dbReference type="STRING" id="387005.A0A183H9C4"/>
    <dbReference type="WBParaSite" id="OFLC_0000408501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000408501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000408501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000408501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14174" checksum="8CC0E78ECAFF684F" modified="2016-09-07" version="1">MYRDAMCGKGIDRHLFALYIVMRYLKLESPFLKRIFPPTFLLSTSQTPLNQCAEEIKQAKMDIHKIATAGGGFGPVADNGYGISYIIVGEDLLSFHISSKRSANNTACFIFPLKISLRIKIIFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAH1</accession>
    <name>A0A183HAH1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4483</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01003420">
        <property type="protein sequence ID" value="VDO40127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAH1"/>
    <dbReference type="STRING" id="387005.A0A183HAH1"/>
    <dbReference type="WBParaSite" id="OFLC_0000448201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000448201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000448201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000448201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20487" checksum="1F6DF68C04E80033" modified="2016-09-07" version="1">MGSQPFSRGVALSRGAEILGSDALLFFIDVDILFTCDTLDRVIRNTVRGAQVYFPIVFSEYSPETWSDSDRLLSDAFHYGRKRGYFRHFGFGLVSIYKSDLDLIGGMNLSIQGWGMEDVDFFEKCVHSPLRIMRAPDPGLVHVYHTMHCAESLPEKQYAMCIGSKAASLASLDSLVDQLPVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAZ6</accession>
    <name>A0A183HAZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4658</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003649">
        <property type="protein sequence ID" value="VDO40653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAZ6"/>
    <dbReference type="STRING" id="387005.A0A183HAZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000465701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000465701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000465701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12424">
        <property type="entry name" value="RRM3_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12427">
        <property type="entry name" value="RRM4_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterogeneous nuclear ribonucleoprotein L RRM" evidence="1">
        <location>
            <begin position="219"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000465701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35375" checksum="A2F9FB784E70460D" modified="2016-09-07" version="1">MLFIGGYGGRGRGGPPADYGYHDDRYGSGYGRGRGNYDEYDGGYGRSEGYGRGDGYSRGDGYYGRGSGRGGFGRGDSGYGRGGYARGRGSGAGLYEDERDYYNGDGPVMMIYGIDQDNFNCDKLFNLLCLYGNCNKIKFMKSKTDTAMAQMGSVRQVYTTIDNLHGTMIFGNKLALRPSKQQILHEIRDPFILPDGTPSYRDYTNSRNQRYTTPELAARNRIVKPTHVLHWYNAPVTMTEEKLKELFIDKGAVTPDKVVIFPQRSERSSAGICEFPNIERATEALMLANHTPVESPVGKAPYIVKLAFAGGRDGKDFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCN6</accession>
    <name>A0A183HCN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5249</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004413">
        <property type="protein sequence ID" value="VDO42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCN6"/>
    <dbReference type="STRING" id="387005.A0A183HCN6"/>
    <dbReference type="WBParaSite" id="OFLC_0000524701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000524701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000524701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Set1/Ash2 histone methyltransferase complex subunit ASH2-like PHD zinc finger" evidence="6">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Set1/Ash2 histone methyltransferase complex subunit ASH2-like winged-helix" evidence="5">
        <location>
            <begin position="80"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO42506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000524701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35165" checksum="29D2C53BC3DF50B5" modified="2016-09-07" version="1">MRQRSTRRGATKPAPSTVCYCGGKREVGTLELYCASCRKWFHGRCLKDLTDFYGLPFMVCYMFNCADCSPTKKETWTPKQANFAHMCVTVLANLTHNARTKRADTGNESDDNDQKLIFLNLENEIIPYFNAQWENLTSMSRRVKNTWHQTLQKSLTKETDLFESGDDGRIFALREHDLSSIGPGHEALKQIGRSKPSISSSARDLTKENFDRSNDLNDGPKTRGSSKRRNIDPPNTFKKAKFTADYASTRITGILAPIDFPFNREGYRYYLVEKDLIVPNRDIFELEESTYNKPIPAHIYRVVVHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDE0</accession>
    <name>A0A183HDE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5502</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004763">
        <property type="protein sequence ID" value="VDO43388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDE0"/>
    <dbReference type="STRING" id="387005.A0A183HDE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000550101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000550101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000550101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000203">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF24">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG MIG-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000550101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34619" checksum="ADBEF1E3872E8E33" modified="2016-09-07" version="1">MVNENTRISFLKISFNEVKVEIRDDSTKLEKSANGLIELVLLSSSENIYCSGTLPKMSNRASKGQFVGTKLKDFNLRKRRSLYDLASENHDLLYMHRNKSDENSITESSLSTVISKRAGEGLADLYASNSDDPYHLEDHVQTSVFPTSPLASSSGVPHCPRRQRRPRKEKYRKAYVPSTISSVTESSLTSLSLPRIDVVTLPMKNGVFLGISVLSHDGGIFVSDIHKGGIVDLDGRIEVGDQIVQVNRNSFENLSDLEAVDLLRKAAASRRPITLYVAKRICSNSDKRTDILSGIASETMPIDISLWVESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDP4</accession>
    <name>A0A183HDP4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aurora kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS5606</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="UZAJ01004905">
        <property type="protein sequence ID" value="VDO43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDP4"/>
    <dbReference type="STRING" id="387005.A0A183HDP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000560501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000560501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000560501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="33"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000560501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34335" checksum="DA6E578EE041560E" modified="2016-09-07" version="1">MDNRQSTKSDDNTEKAASTNTRPKIREWTLNDFEVGRPLGRGKFGNVYLAREIESKFVVALKVVYKTHLGSDSLKRQLQREIEIQYHLRHPNILRLYGYFHDKDRVYLVLEFAPRGSLFQHLQQMKTFPPELAAKYMYQLASAMEYCQQKKVLHRDLKPENVLISANGDLKLSDFGWSVHEPSSKRTTVCGTLDYLAPEMVPNGTHNAMVDNWSLGVMLYEFLVGKPAFEAKTYQDTFENIRKCKYTFPSEVPDGAKDLISKLLQRDPAKRLSLKDVLNHSWIQEMITKNTDAKKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEF8</accession>
    <name>A0A183HEF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ligase_CoA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5870</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005284">
        <property type="protein sequence ID" value="VDO44620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEF8"/>
    <dbReference type="STRING" id="387005.A0A183HEF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000586901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000586901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000586901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO44620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000586901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22201" checksum="B2FB9A785B569B7C" modified="2016-09-07" version="1">MAEDINGNLYCLDCKLNVDSNARHRQQELFAMEDKQQQDPLELRAAKADLNYIRLDGNIGCMVNGAGLAMATMDIIKFHGGDPANFLDVGGSATVDQAAEAFRIITADTDKVDAILVNIFGGIMRCDVIAQGMINVVNELQLKIPVVVRLQGTRVEEAKALIADADLRMLACDDLDQAAKMVVKLSEIVQLARSVPIDVSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEP6</accession>
    <name>A0A183HEP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005406">
        <property type="protein sequence ID" value="VDO44932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEP6"/>
    <dbReference type="WBParaSite" id="OFLC_0000595701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000595701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000595701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000595701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45655" checksum="28DE5759BDB2CD4A" modified="2016-09-07" version="1">MLAITQKNAETEMNVSLSLKVINGIYVCMPLYSADLSENLSALLISLQSTDINVCVKKELACQATFHKFKVKFIDNFDDQTLNDTWIENEPSDPSRSNYFYFPQGTYQFVSRATAASDLSENAKWTLSIKWQMCGMVIDLDQRIGKHASLLISTFSSLTSDMNEEDWEELANESSIAYDDDDDQDAEIDATGELGNLAQPEERIQWLERKMHEQSVLVTDLMQCGASEPAIEKERRTLRKLESARFKQFRKSIIEKLKRNAIRQRKKLMDPKKPIGIHETRQVANILSSEQSDDRSQISSATVKKNALLNLQLNELPRTTERGSSSGRSSESNFMASTVDMNIDVQLSIESGLCTLRTLGKPEESTALLTKRPSARDLKSKMAQTNESVAVTKLAIPRLKHNKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFL1</accession>
    <name>A0A183HFL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4203 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6272</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005866">
        <property type="protein sequence ID" value="VDO45989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFL1"/>
    <dbReference type="STRING" id="387005.A0A183HFL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000627201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000627201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000627201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="2">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000627201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23832" checksum="CC862AE80935F0EA" modified="2016-09-07" version="1">MFTLLRLYLREKYNHSARVNEQERIFGIYPTANSIGISGNETTSAQSASVGVRVVAKYWVFVVSLVLLIISIRAPPVLYTVGFFVLFSGLIVLLLSSFGCLRRLLCSYFTFLAIYSSAVVLVLYCYQFPSIPSIWQKATGFNNDWNHDIGLVNYKQEGDRKALLVHLIGPISLFIVTMLHIKFFYDLWCPFVSTAPNATATNVDIESSDGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGF8</accession>
    <name>A0A183HGF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4276 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006322">
        <property type="protein sequence ID" value="VDO46973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGF8"/>
    <dbReference type="STRING" id="387005.A0A183HGF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000656901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000656901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000656901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000656901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="21037" checksum="6C4AF84F81EA6D00" modified="2016-09-07" version="1">MINEWRRSSRQHAFSYYAHFFFEFVPFSNDTLINYKLTKPKKWEEASLLHFFFLDPTTVAEYRSECRNEISEWFATLSKIEGAEWLIVFDSLKAREKKCRGALIERIKSDFAKFTNRIIEISDPSHIVLLQNSVQSHLLNSLEDYITHEENSLSNRNDRYSDPDFDFITFCRDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGH4</accession>
    <name>A0A183HGH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6587</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006348">
        <property type="protein sequence ID" value="VDO47015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000658501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000658501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000658501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF31">
        <property type="entry name" value="LD31969P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ankyrin repeat" evidence="5">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000658501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27358" checksum="C5F590F303F731D5" modified="2016-09-07" version="1">MLNTVTKKTSSFKATLWLCDHYPLDLQDQVLPIIDLMAVNNAHFARLKNFIQLQLPAGFPVKIEIPLFHIVSARITFSAVNTSGPHVSYNVSLNEIEVDPATFEIPQYYRCLDNDDYDLSEDELYLQFALEQSMRETAGSSASNAITYGMDSVSNVLDCHGDIDLAYAIGESMRTLRLEQLMREGTRTADDIISTECQTVMDNDLQLAIQLSQKEEEERLKACKEQEQELERIIKLSLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI14</accession>
    <name>A0A183HI14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7125</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007224">
        <property type="protein sequence ID" value="VDO49440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI14"/>
    <dbReference type="STRING" id="387005.A0A183HI14"/>
    <dbReference type="WBParaSite" id="OFLC_0000712501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000712501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000712501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SB" evidence="7">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO49440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000712501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26218" checksum="17560576A30A52EF" modified="2016-09-07" version="1">MAMCFQDSCPVFAKPNNNSRSSGVGSTSASQVQSYTPYPISNAPGIPPYPTTPGSYPSMPHANVGSGTVQPEHLKASVMSAVEHKIRQRLREKLGTMHAELASIRQTHADLRAGQQKLKVIVDDLAQEQKRMEDALIVYQEKKAEITSLLSTSSSEKIVEIDQVIDACTPLHRQLLRCYVYDCAIDDAIYFLGQALSRGRISLTNYLKEVRQLSRRQFIYRATLQKCRIKAKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIN5</accession>
    <name>A0A183HIN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit NCLN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS7348</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007616">
        <property type="protein sequence ID" value="VDO50550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIN5"/>
    <dbReference type="STRING" id="387005.A0A183HIN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000734601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000734601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000734601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO50550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000734601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23345" checksum="4063C5836A0F4F4B" modified="2016-09-07" version="1">MYEAVSLDSNVLRRCLVVNWRDLLGRDLQVLFNQAFGAAIIVLPANLDTLTPSTKTKLASLEKSLLYLNTNVAVYVVQQQPELQLLVTEIATFSKRSPTAVQQLLGAISANIFQFSSTTSVSNNVVIPKSANVIGHLWSTDRNSPFVVVVAHYDSHSAIPGLAVGADANGSGVAALLELLAIFSRFYGSVSLHCFNNLRYLLSIGPINLLPSFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJD0</accession>
    <name>A0A183HJD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008031">
        <property type="protein sequence ID" value="VDO51744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJD0"/>
    <dbReference type="STRING" id="387005.A0A183HJD0"/>
    <dbReference type="WBParaSite" id="OFLC_0000759101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000759101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000759101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000759101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15931" checksum="E1EF39667AF34278" modified="2016-09-07" version="1">MQQGIQEIYVSTFPETFILVIVGQLLEKILETRKEVFGHMLTNLTTNMIRTGDHVIIQKMGGEHLRVCKITRKTKILIEKLRFEIDGAIDQPFGLFEVSAGKVTRVAPESITDIAASFDFGMNRMTFRMLPYISFENKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT3</accession>
    <name>A0A183HJT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7745</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008280">
        <property type="protein sequence ID" value="VDO52385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT3"/>
    <dbReference type="STRING" id="387005.A0A183HJT3"/>
    <dbReference type="WBParaSite" id="OFLC_0000774401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000774401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000774401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000774401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23626" checksum="28F4542F20121F39" modified="2016-09-07" version="1">MQSIRNNEYFSLVPLWDSPNGPNVPLIPLQPISSEHNDEIIATANTSNISNAVITPVHHIFTNAYMQIQPEIQTSVETSSSNNTIDSKKRHHRRGVKTMEDVSFAHNLCLDSNGSSSIVCHQQNIEWENNRKRNKRNMINTRSSKRCLRNRSRSLGAHQRSQVQRSHRPSFPTNLATTAASSSFSSNVAAIADVSTSLREQSKQTFETISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJX2</accession>
    <name>A0A183HJX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual specificity protein phosphatase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7782</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008346">
        <property type="protein sequence ID" value="VDO52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJX2"/>
    <dbReference type="STRING" id="387005.A0A183HJX2"/>
    <dbReference type="WBParaSite" id="OFLC_0000778301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000778301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000778301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF9">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000778301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21803" checksum="76749FFECD6046C4" modified="2016-09-07" version="1">MSLVSFNVDPEYAQITEIVRGLYICGVSSLTAENMKKYNISFIVNATNEVPNVLSLGNIPRVKLWLEDNPQVSVYPLLDHQADRIEAEIASGGNVLVHCVAGVSRSATICLAFLTKFRCRSLRQAYHVMAKKRPLVRPNIGFWRQLIAYEQDVKQNIGTVQLVRNEEYPDQVIPDVYLDEEIRAHKLSPTVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKT7</accession>
    <name>A0A183HKT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA_6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8094</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008893">
        <property type="protein sequence ID" value="VDO54003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKT7"/>
    <dbReference type="STRING" id="387005.A0A183HKT7"/>
    <dbReference type="WBParaSite" id="OFLC_0000809801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000809801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000809801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000809801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9663" checksum="CE049CD220CE58C6" modified="2016-09-07" version="1">MARTVDIRRNLNVDLKQIESFVHLSLIFGMAKTDPNDEETILTSCKINAPFSPADDDLKFVDEDVSERFFQAFVDQVRQETALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL16</accession>
    <name>A0A183HL16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS8180</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009043">
        <property type="protein sequence ID" value="VDO54409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL16"/>
    <dbReference type="STRING" id="387005.A0A183HL16"/>
    <dbReference type="WBParaSite" id="OFLC_0000817701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000817701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000817701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO54409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000817701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34690" checksum="DE96203A3F69426B" modified="2016-09-07" version="1">MNGVNFLQVVNAAYLLSVRDSQVARDNMEAFKNAWIEKMKLLTMAVDSMITVDDFLAVSEAHIIEDVKSGIQAVINGDGYLLDRSAGGIRGRSLRVCNVVDSEMDLVAASSYRDRVRMATKLLRDDVINQFSDRAEKVVNKLENEATEGNNDENRNYVDDVDEFIEASELVHNAVKEIRNALLMNRNPEDVDSDNEYEDDAGTNYPDSRNQVTDIENEQKIMRQLPEEEKRKIQEQIDVFKIAQSKFEREVAKWDETGNDIIVLAKHMCMIMMNMTDFTRFVLLRIESFEELIVRLYATWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMY6</accession>
    <name>A0A183HMY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8849</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010348">
        <property type="protein sequence ID" value="VDO57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMY6"/>
    <dbReference type="STRING" id="387005.A0A183HMY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000884701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000884701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000884701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000884701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20104" checksum="ECF89168CB0B39F8" modified="2016-09-07" version="1">MRTTCNHALYAVVDVFTQYYPVLSTILLTNIYEQLYWCAQQENEQLARSAINCLESLLLLNGSKFTVEMWNETIILIANIFNITLPHSLLTWEPDNVLNTFIIPNGENYQGCNNGPHQIVVNSRNSDALFTTLLVRCVVQLELVDAVSSIIFGQESMKKDEARANALLISSTITKSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HND5</accession>
    <name>A0A183HND5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010629">
        <property type="protein sequence ID" value="VDO58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HND5"/>
    <dbReference type="STRING" id="387005.A0A183HND5"/>
    <dbReference type="WBParaSite" id="OFLC_0000899601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000899601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000899601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000899601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13126" checksum="E5BC0E5537FEFF05" modified="2016-09-07" version="1">MAARTFAASFTPFACQMKLAMVLVDVQINALTIIPVSFTLQPYYSFAIYGFSGTICATDGITYRSECHMRLAACQQQKFIVIAFRGSCDSCSNVACLDGQQCEDGICSCPSSCPDSAENSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNI6</accession>
    <name>A0A183HNI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9045</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010719">
        <property type="protein sequence ID" value="VDO58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNI6"/>
    <dbReference type="STRING" id="387005.A0A183HNI6"/>
    <dbReference type="WBParaSite" id="OFLC_0000904701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000904701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000904701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000904701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9820" checksum="C7E3DBAA63FA9A62" modified="2016-09-07" version="1">MTFWGDVIVTPLEAAYVDKVMEPMYEDEISVVQNIMAQRRMSSLAGPFELMMPKSLDLNAITDALNRMFPSLQLCPARIQKPTVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP11</accession>
    <name>A0A183HP11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS9224</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011092">
        <property type="protein sequence ID" value="VDO59242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP11"/>
    <dbReference type="STRING" id="387005.A0A183HP11"/>
    <dbReference type="WBParaSite" id="OFLC_0000922201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000922201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000922201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO59242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000922201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14520" checksum="4EDC71BF0FC67682" modified="2016-09-07" version="1">MHTDTILYSVGVIFDTWSLHYDHEIWGNDVKQFRPNRFLNCTTIQRKNWMPFGAGPRQCIGMRFAILETKIIMCRLLKKFRFRKIENKSEIQVSLREMGTVWPDFAQVILEKRLGEYFFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPD5</accession>
    <name>A0A183HPD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional acetaldehyde-CoA/alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9349</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011371">
        <property type="protein sequence ID" value="VDO59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPD5"/>
    <dbReference type="STRING" id="387005.A0A183HPD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000934601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000934601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000934601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000934601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5366" checksum="67DAC88B495E8584" modified="2016-09-07" version="1">MMNFKIGGPEERMPLPVIHAFGILKKAAALVNKEYGLDQKIVDAIAKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQB7</accession>
    <name>A0A183HQB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal nicotinamide adenine dinucleotide carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9680</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012139">
        <property type="protein sequence ID" value="VDO62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQB7"/>
    <dbReference type="STRING" id="387005.A0A183HQB7"/>
    <dbReference type="WBParaSite" id="OFLC_0000967801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000967801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000967801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000967801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20472" checksum="FB97C149A62E9B46" modified="2016-09-07" version="1">MKGICIGNIYIDRHYPEIGGKPINLDKEESEMSDAESFRRVLRFAIRESISRTIAVMVSRPFTVVMIRQIAQIVGGELKYHNVLSSLRLVGIEEGPKGLFSGLIPQLIAEYLSIWGVHMLLYGIERVTLRAQQDAIRSNNKEEENFIVSTRKMLHLVAPIFVNSFTYPFQVVSTVMAVTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQQ0</accession>
    <name>A0A183HQQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012463">
        <property type="protein sequence ID" value="VDO63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQQ0"/>
    <dbReference type="STRING" id="387005.A0A183HQQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000981101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000981101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000981101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000981101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17388" checksum="8F9BAEFF10930E6B" modified="2016-09-07" version="1">MIIFFFFLRRVRFYRCEDALEVLRIFDGYRFRNRFLSVRYEDNVTYNTFELDKQPIKLELESKMDYPLDMNIVPNINKNVWTATEFVQIELFKNDLMRLLENTGMDNAGICIDDSRIMQLTFRGSALIEAMLKQWPIGLFRMCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR57</accession>
    <name>A0A183HR57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012795">
        <property type="protein sequence ID" value="VDO64799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR57"/>
    <dbReference type="STRING" id="387005.A0A183HR57"/>
    <dbReference type="WBParaSite" id="OFLC_0000996801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000996801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000996801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000996801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7644" checksum="97004D65F856063F" modified="2016-09-07" version="1">MHLVPWAVAHRPDQWYPFKIALKKEFTPGERVISNIPFLNGESLEFLASASPGITIWKEFTSRSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRD3</accession>
    <name>A0A183HRD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012980">
        <property type="protein sequence ID" value="VDO65394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRD3"/>
    <dbReference type="STRING" id="387005.A0A183HRD3"/>
    <dbReference type="WBParaSite" id="OFLC_0001004401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001004401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001004401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001004401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12077" checksum="99F57C0172C354B1" modified="2016-09-07" version="1">MVIEGLNTKSTAFMEEKMTSDVVMSRIFGAELTTQSTDASSRNDYDDDDMTEKMGKETTATTNEFGFPIESKNAASTVDNVDKSATKVHIQIQVILSHPKKKNEIRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRN0</accession>
    <name>A0A183HRN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013224">
        <property type="protein sequence ID" value="VDO66160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRN0"/>
    <dbReference type="STRING" id="387005.A0A183HRN0"/>
    <dbReference type="WBParaSite" id="OFLC_0001014101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001014101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001014101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001014101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15526" checksum="1C8C32AEB2E58BAC" modified="2016-09-07" version="1">METLATIWQQVQMKYKEEDGNLIKCHAIMYEALQYYCQKIPNTKKHIRKLEEIADRTIDALDKIITIYESTYKLTELIDRLDSYCYLCCTLNESPQTLCLAFNKGKLQCKFQKKFFFNLNFFSFIFNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRQ9</accession>
    <name>A0A183HRQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013295">
        <property type="protein sequence ID" value="VDO66440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRQ9"/>
    <dbReference type="STRING" id="387005.A0A183HRQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001017001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001017001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001017001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001017001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15189" checksum="0C08CFC8825DE0F2" modified="2016-09-07" version="1">SRRSGLIGTDGWVAPEALISDASVTCAVDVFSLGCIYYYVLTNGSHPFGDALKRQANIMQGEYSLKLLSTAGNLMAVSLIETMLRRDPSLRPISATLAVHPFFWSKERQLRFFMVTVPLVPIKPYYFMRYAIRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS31</accession>
    <name>A0A183HS31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF115 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013559">
        <property type="protein sequence ID" value="VDO67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS31"/>
    <dbReference type="WBParaSite" id="OFLC_0001029201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001029201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001029201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF4">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001029201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20268" checksum="A2F2F9F558981733" modified="2016-09-07" version="1">IISISTTVPITLLESIIGNVCRQSIEKSVIFIEPNSSFQKLFEFPENDHMVSGYQAPNYQTYADYIYLNQWHPITEVSDSNFLYDGGVESFRPSYLSCLSGKLVDELFLIYCQQHKPSNCHNLCTYEHRKQIVAETLIQVTQQDACDLKYLSSILYCGNRNYWQLLEMVSLKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSG7</accession>
    <name>A0A183HSG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS10425</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013874">
        <property type="protein sequence ID" value="VDO68337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSG7"/>
    <dbReference type="STRING" id="387005.A0A183HSG7"/>
    <dbReference type="WBParaSite" id="OFLC_0001042801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001042801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001042801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO68337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001042801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11611" checksum="6DA415561C439796" modified="2016-09-07" version="1">MRPPLPRESEAEIYWKVIDDNTIVDGDEKSYTFDQVYREVDLTQDVYDNSAKDVVESAMAGYNGTLFAYGQTASGKTYTMFGMDNTEGIVQMALDTIFAKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT05</accession>
    <name>A0A183HT05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014353">
        <property type="protein sequence ID" value="VDO69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT05"/>
    <dbReference type="STRING" id="387005.A0A183HT05"/>
    <dbReference type="WBParaSite" id="OFLC_0001061701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001061701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001061701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001061701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="6566" checksum="FF262A0704983E38" modified="2016-09-07" version="1">MENFGALISLSANSVPESPSTYAPPLSAAAAHHQPTTPYSSKLSRQSGILIYSSDQGGKGIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT08</accession>
    <name>A0A183HT08_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-secretase subunit PEN-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS10621</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014359">
        <property type="protein sequence ID" value="VDO69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT08"/>
    <dbReference type="STRING" id="387005.A0A183HT08"/>
    <dbReference type="WBParaSite" id="OFLC_0001062001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001062001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001062001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO69992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001062001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11888" checksum="AF71D0B75C15D36A" modified="2016-09-07" version="1">MDLKKMSNEDKVILCRRYFYIGFALLPLVWIVNAVWFFKSAFIDKSPVQKTIRRYVLYSIIGASIWVLALIVWEIFFQLERAKGLEWTDRLSFVFPVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT37</accession>
    <name>A0A183HT37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014415">
        <property type="protein sequence ID" value="VDO70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT37"/>
    <dbReference type="WBParaSite" id="OFLC_0001064901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001064901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001064901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001064901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11438" checksum="3500802C9745AF19" modified="2016-09-07" version="1">FVNHASNVGQRISTNPGLSSVELLAIIADRDAEIKQLKNELLQKSVEHQLQISRVLEKVSDLVKAAVNTNVQREIMSAMTGMAGFSGFHDNGYCDKSYDDDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTH2</accession>
    <name>A0A183HTH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS10783</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014781">
        <property type="protein sequence ID" value="VDO71301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTH2"/>
    <dbReference type="STRING" id="387005.A0A183HTH2"/>
    <dbReference type="WBParaSite" id="OFLC_0001078401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001078401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001078401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO71301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001078401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9740" checksum="DA455BAAFEED349E" modified="2016-09-07" version="1">MHHMFLTELVRGMGIIVGHYFMEPATINYPFEKGPLSSRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAESRPDGSRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTL5</accession>
    <name>A0A183HTL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit RPC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10826</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014890">
        <property type="protein sequence ID" value="VDO71656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTL5"/>
    <dbReference type="STRING" id="387005.A0A183HTL5"/>
    <dbReference type="WBParaSite" id="OFLC_0001082701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001082701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001082701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO71656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001082701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="21024" checksum="7567FEE20B2A2445" modified="2016-09-07" version="1">MVLPLEKTDELQYMIELRQELLSRFHESSFYFEVKERSSEFRRYTDKYREIEKEEFRPDWSRLPDELCWTKNVDKPVKKKRKIIDKGTDEVVEKLSKLEESEKLGSSEVETQETIDENDEESEKEEQNNENEEQEALSDDDYQEEDNDYIHSYFDNGENYGDIGSDDNLDEDNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTR9</accession>
    <name>A0A183HTR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015045">
        <property type="protein sequence ID" value="VDO72149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTR9"/>
    <dbReference type="WBParaSite" id="OFLC_0001088101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001088101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001088101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001088101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5915" checksum="F6DF5FB3B64FC1DB" modified="2016-09-07" version="1">MKLWVSRGGRLDEELNFLRNLQQNNHYSASRQKRLSDFENSSLFYNTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTX4</accession>
    <name>A0A183HTX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015184">
        <property type="protein sequence ID" value="VDO72535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTX4"/>
    <dbReference type="STRING" id="387005.A0A183HTX4"/>
    <dbReference type="WBParaSite" id="OFLC_0001093601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001093601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001093601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001093601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15249" checksum="0E72333A0D827FE7" modified="2016-09-07" version="1">MLTFESTIQDPKYHSSLGNINVEKKEAFFHSISKTEETFNEEETNSDQKPSEELLKAIFGDSDESSTDTENEELQDNQEEITVPSMSANFFDNRTEESKFVVPTKMLTVMDMDLSSNNDNEEFGPVPPPSISSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUQ9</accession>
    <name>A0A183HUQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11221</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015931">
        <property type="protein sequence ID" value="VDO74855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUQ9"/>
    <dbReference type="STRING" id="387005.A0A183HUQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001122101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001122101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001122101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552636" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO74855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001122101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12065" checksum="E1A39FF164B0AC01" modified="2016-09-07" version="1">MSDFHCLLLRLLLWYSVLLTDSYRLNVPRVLLPYHPTVHVTFDLIVSDPSNGCFTWRSTRPDTVSVKVVNPIGMKKCSAKAQIAATSKYAEEQTVVVFAEDKGYMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV51</accession>
    <name>A0A183HV51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11365</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016344">
        <property type="protein sequence ID" value="VDO75934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV51"/>
    <dbReference type="STRING" id="387005.A0A183HV51"/>
    <dbReference type="WBParaSite" id="OFLC_0001136301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001136301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001136301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO75934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001136301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17308" checksum="FB7F64F6111DD680" modified="2016-09-07" version="1">MASTKASYRKKKNLVELSLLASKTGDTKTAQRRNVSPKQSSQYASEKKDQNEKVANIAKLKKNDRINKWIILEFIGRGSFGCVYKVGYHGERFALKFDLGYGDEKSLLVERNVLELAKRANSKHICRLIEHGKYSSFEYIVMTLVGKSLRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV76</accession>
    <name>A0A183HV76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS11389</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016389">
        <property type="protein sequence ID" value="VDO76060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV76"/>
    <dbReference type="STRING" id="387005.A0A183HV76"/>
    <dbReference type="WBParaSite" id="OFLC_0001138801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001138801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001138801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO76060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001138801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16671" checksum="A7BC998D38639E7E" modified="2016-09-07" version="1">MRIISEELCVNFQGKGTADWRADFKRHLPDCIDAFEPCYILFRIDEPYGWILMSFADDRAPVREKMVFAATWATFKSEFGQSNIRYEYHVTDKKEMTLEAFEKWLSSKEDLGPMSELEKEFYNAHQELKVTVPSVVAAQTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVH6</accession>
    <name>A0A183HVH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11490</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016639">
        <property type="protein sequence ID" value="VDO76835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVH6"/>
    <dbReference type="STRING" id="387005.A0A183HVH6"/>
    <dbReference type="WBParaSite" id="OFLC_0001148801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001148801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001148801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001148801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8587" checksum="3D0588D1068646EB" modified="2016-09-07" version="1">MPLPPPPTLSQRPSITNSMTAPLDSTSSKTNEFESGRTGSYQNYNDATHNDALITKCNHFQEQVQSALHPVRQQISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWR7</accession>
    <name>A0A183HWR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11928</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017870">
        <property type="protein sequence ID" value="VDO80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWR7"/>
    <dbReference type="STRING" id="387005.A0A183HWR7"/>
    <dbReference type="WBParaSite" id="OFLC_0001192901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001192901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001192901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001192901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9765" checksum="361F50D46CE6C0D3" modified="2016-09-07" version="1">MAFGSILDGPNEAVLTQLVESALISIIAALSDPQLQVRDTAAWCIGRVCDTCEEVVTRQEILAPMLPALSTALQQEPRVAANVCWVTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWS5</accession>
    <name>A0A183HWS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formin_GBD_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11934</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017883">
        <property type="protein sequence ID" value="VDO80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWS5"/>
    <dbReference type="STRING" id="387005.A0A183HWS5"/>
    <dbReference type="WBParaSite" id="OFLC_0001193701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041387">
        <property type="entry name" value="FHOD1_GBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18382">
        <property type="entry name" value="Formin_GBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHOD1 N-terminal GTPase-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11660" checksum="C4116BCBD762FF94" modified="2016-09-07" version="1">MVMVNRLNCRIQYVNDSDPFATTSSSHLEPNRPVMYNFSLHQPIGEQLPEVIRTLRAPHKPGNAALQIYKYEDSVGDYGSYLDSEMSLMEQEDELEILKADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX28</accession>
    <name>A0A183HX28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur-regulated basic protein FbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12041</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018184">
        <property type="protein sequence ID" value="VDO81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX28"/>
    <dbReference type="WBParaSite" id="OFLC_0001204001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001204001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001204001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001204001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3604" checksum="23D8BA09F76751A9" modified="2016-09-07" version="1">MIKKCIDILIEKEYLQRVENEKDLYEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXN6</accession>
    <name>A0A183HXN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type proton ATPase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018786">
        <property type="protein sequence ID" value="VDO83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXN6"/>
    <dbReference type="WBParaSite" id="OFLC_0001224901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001224901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001224901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001224901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13371" checksum="D2A55D145567D512" modified="2016-09-07" version="1">VENWRQYRIISEQKTKKLAKVKQKLQCALQNSELEVSRMREKVRKAKKDFNYCDKQVAEYTAAVEAARYEQDEMERESKDLDEILAGAEKSVIESILKVKIQIYEQAKEEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXV2</accession>
    <name>A0A183HXV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12316</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018986">
        <property type="protein sequence ID" value="VDO83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXV2"/>
    <dbReference type="STRING" id="387005.A0A183HXV2"/>
    <dbReference type="WBParaSite" id="OFLC_0001231501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001231501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001231501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="3">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001231501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14038" checksum="24D536466029D7B1" modified="2016-09-07" version="1">MEKKLNDTLIMSEKERRDIEVLKETADRAITRHRQMRQQIEDLEEEVCRERSKCRQLQRSIDDINETNETLTRENAQLKSLAALARRCGFNRASTSRFGSTHIVYFIVIVIKNALSESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYF3</accession>
    <name>A0A183HYF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12515</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039858">
        <property type="protein sequence ID" value="VDP11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYF3"/>
    <dbReference type="WBParaSite" id="OFLC_0001251601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001251601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001251601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001251601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24220" checksum="5E801B9572D37A3B" modified="2016-09-07" version="1">MGRGRGGQSVTFCSTVVYNGDDDDDDECVEWSDNGLLRESTSIAPAFDIVDIDIDIIDTIDIDIAATSMKAMQISENGWCKSTSHTAGWVRLDLAPTHTTQFLFVAGARSGSLSAGWLCPSTGYVCPRPRFSLSCSVLEEEEKWRVAEMGKVHGSLDFSGPSCIEKSPFIRSSIENSPYHGPHLSREGVRPSKCFDSSSIRYDLNMTIFACMFMAKLGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYG9</accession>
    <name>A0A183HYG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12531</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039860">
        <property type="protein sequence ID" value="VDP11529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYG9"/>
    <dbReference type="STRING" id="387005.A0A183HYG9"/>
    <dbReference type="WBParaSite" id="OFLC_0001253201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001253201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001253201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552676" evidence="2">
        <location>
            <begin position="16"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001253201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46669" checksum="FCEB802989A20626" modified="2016-09-07" version="1">MFLSMMLFLVRITSSQQHSVTDSSCSEYTIPFSFQNDKIGNPTLLCTSPVCFDEKKLYELKRDDVIPETDTETKDLLFWKNYVYKAQCHKFYQNISCTEETQWTIGLLLEDDENNVKVKWKCCNYEGLRYARALKTVIVKIGESYTGGEVYRNGRRVAFDLIKEVHLLFDEQHRPRYELKIMRLACVPKPIDFKNKLTADKNSELNSSAIDVSSEYDTEEYVFTNQHHTKYSKPRRRSTILDDENSDYLFSSRHRMAHRKMFSLHRRPFYKPIAGDYDYYDYDPVILRRRPSVHPRMIADGLWPINLGIMGRSRPVVAAAPLSPALYKITSPNAIDGDYHQFVDSDNTATPINSAQAEVYSQLSPAVSAFMNGYNMLIINQPKMKYKLFSLLNYLKSIKDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYL2</accession>
    <name>A0A183HYL2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12574</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01039872">
        <property type="protein sequence ID" value="VDP11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYL2"/>
    <dbReference type="STRING" id="387005.A0A183HYL2"/>
    <dbReference type="WBParaSite" id="OFLC_0001257501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001257501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001257501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001257501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17307" checksum="20173587E7A19900" modified="2016-09-07" version="1">MSATKERTFICIKPDAVQRGLIGKIIERFEQRGYKLVAMKMVKATKGHLEIHYQELQGKPFFKDLVDYMSSGPVVAMVWEGLDVVKQGRQMLGATNPLNSMPGTIRGDFSIQTGRNIVHGSDSLPSAEREIAHWFKSEELCEWNAATTTWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYX3</accession>
    <name>A0A183HYX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12685</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039904">
        <property type="protein sequence ID" value="VDP11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYX3"/>
    <dbReference type="STRING" id="387005.A0A183HYX3"/>
    <dbReference type="WBParaSite" id="OFLC_0001268601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001268601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001268601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07626">
        <property type="entry name" value="BAR_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11763">
        <property type="entry name" value="SH3_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="212"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001268601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="64112" checksum="3F5B78E95EA82905" modified="2016-09-07" version="1">MTQVRAVYEFEAQPNSGELSISVNEVLTVVREGIQGGWLEGRNAKGQHGLFPESYVVKINASPTLPEQVTGWGIPFLDKSEQLVYIAVKMLLGLSDAFPSQHHNLPAFAVEDSWNAPPASAHYPQLSIPSNEQQWHNVAAPSLFVSASHEDDDFDDWTDDDEEFPESVLNTADNPEMQNYISSNPTTKGDVLVKQGTLTLDGAEWVPVAQPYYCIVDKPKKESKLKGLKSFIAYSVKSSLSGIQVSRRYKHFDWLYERMSAKYILIPLPPLPEKQVAGRYEEDFIEHRKNILQIWVNKVCRHPVLSKSDVWIHFVTCTDEKKWKSGKRKAEKDEYVGGNFLYSITVPNQPLDSSDVYAFNFYSDLSEQKVDNFTRSMRSFEESVHFMYNRVSETHKRLAGPYKTNWQKMGEACTGLCRSFDINPSSKNEKVTSALKETAKTLQWIGDEHEKLAKKSLDPLLDALYSYKGMLACIPDIVNVHKSAISKLRENEKLAIEGRVSSADMDKVKEKVDSISYMMLAEMAFQNHELGEDFKNMMATYLESQGEFFMNIGNQLNNLARKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I018</accession>
    <name>A0A183I018_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein NOP53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040036">
        <property type="protein sequence ID" value="VDP12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I018"/>
    <dbReference type="STRING" id="387005.A0A183I018"/>
    <dbReference type="WBParaSite" id="OFLC_0001308101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001308101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001308101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001308101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24851" checksum="FB3E925564725C60" modified="2016-09-07" version="1">MRSQKQVRRTVKVRSLKNAAAGKWKTYRRRLEDRKACSTLTPPPPTHRRIKEPKQRSPEELAERQHLREQRRLEKKLAKQRASTSTLPETKKEKRLKEISSNDSTKKAVSAERKIAAKTIKAKNSMMIKETTKAKRLMNEQVQRTVNVAEQDISPKKLNELKVMEVSKLQNESESNHQCLKEERSVSAEEQKICQSSSPIKIEQKVLMQLKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I040</accession>
    <name>A0A183I040_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MHD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13102</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040046">
        <property type="protein sequence ID" value="VDP12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I040"/>
    <dbReference type="STRING" id="387005.A0A183I040"/>
    <dbReference type="WBParaSite" id="OFLC_0001310301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001310301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001310301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD1" evidence="7">
        <location>
            <begin position="173"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001310301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="611" mass="70106" checksum="F24C962BAC205282" modified="2016-09-07" version="1">PDGVGTVTLEEKEKFQDVKERLRTLLEKQITNFRYCFPFGRPEGALKGTLSLLERVLMKDVVSPVPPEEVRNVIRKCLQDAALVNYTRICNEAKLEREVLHQGYSNKHHNSDKILERMGIDVSPQQRIEDMIRVTEYCIELLRETEEHHGDAFTWFSDLLADHSEIFWSLYSVDLDAALNVQPPDSWDSFPLFQLLNDFLSNNPYLKNGIFHTKLIQQFSTKVVRYVDLMEQSIAQSIERGFARERWEVRKDGCATSEDTYWKLDALQIFIHDLNWPEEEFSKYLQIRMKALASEMISKCTNCTYQCFDSYMQRARKSTDYILPSEVCVMINVIFSSKSRAAKMAIDSGEYKYQSKLDETLDTMLKDMETCIEDKLLSVLEYVLSRLARYDEGNPIGAILSIAPKPTTIFNKMKNIVGDQGIVGNLTGNVASSPQNSFQKPIVSQPQNSGHYGHSYVNFMRVCTEQLRQVVIDELWVNALFEVSHLISSLYEGTKHWYEGQMKMINDWLTERLQQSLSPYQLTCLSFMVKKIYSDSELQGVDDERLNSKIYQSITRRLQIEEANCALNDNASGHANISISNHALIDNATQAVTNVSSLVEGASAKMFSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I043</accession>
    <name>A0A183I043_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable DNA-directed RNA polymerase II subunit RPB11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS13105</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040047">
        <property type="protein sequence ID" value="VDP12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I043"/>
    <dbReference type="STRING" id="387005.A0A183I043"/>
    <dbReference type="WBParaSite" id="OFLC_0001310601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001310601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001310601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="13">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor Iwr1" evidence="12">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001310601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45552" checksum="8021BF552A838FFB" modified="2016-09-07" version="1">MNAPAPFESFLVFDGEKKITIEKDTKVPNAAIFTVNKEDHTIGNLLKHQLLKDPQVLFAGYKCPHPLEHKFVLRIQTTSDTTPADALTSAITDLMAELSLFEERFRVMMLTNHLTSPPSTSSPSSYSTIFRVRRKRTADPLGALVISLKRAKQMPAVTEPIICFRTSTTDLKVLFESTVIYVVVPYISFSFFIPYAVNVENNLVGIRSYNSFLQHFNIIDVDPHQNIINAVNLPSSNIDEVAEDSDNKSEISITNPVELMKDFAEEPSSSSKIISETTIKSSQITLNGEPMVVLSNQDDEDFIFDYYWSSKADGCTAYQIRDVRLANADDLLCDGEDTESSAGEDDDEDSNDENNWRNDYPDESEHTSGCGSDEDTASDGFDDYEDLEKHIGKMGFYDEDSEGDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I051</accession>
    <name>A0A183I051_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13113</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040051">
        <property type="protein sequence ID" value="VDP12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I051"/>
    <dbReference type="WBParaSite" id="OFLC_0001311401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001311401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001311401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001311401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12844" checksum="D0E6B31DFFC6C37B" modified="2016-09-07" version="1">MIAEFVHSQYRVIIAVTAILVGIFPQTYLFALSSRQYTRSQGQLCCADDMDISCLCKRVCMDTANGISILCSEVSLLFIAIPKTKGSVRSRFEEEINRKYDSIKYLKSRTTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I064</accession>
    <name>A0A183I064_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SERTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13126</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040055">
        <property type="protein sequence ID" value="VDP12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I064"/>
    <dbReference type="STRING" id="387005.A0A183I064"/>
    <dbReference type="WBParaSite" id="OFLC_0001312701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001312701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001312701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001312701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42401" checksum="424ED4DA7595E34C" modified="2016-09-07" version="1">MKWDCGGVRWPSSAKRTRMLTSSYSVNIVDTHDNSGASDDGDESAFSSCYQMVTTESTGTMISEDSVPPVTTYPKLLTGNDVYGNILNNHTVRTIPNSDPLPVANSLSEAEIVNLLCRNLCDIERIIAQQRTAYSGTSPIQVPSLLSQRSNGEQKSHIGYTGSVILPDNEQQQQQQQYRYHHTVTMERRRSSTLDSSDTRRFHPYATTTTTTATTTMITKIAPTTACSSNSITVWSPSVPSRADLKQKYLRSLAPVLYDLLTDDCESKNCQKTTDSMNCSIFKSCVEPSMDSYLRSLSLLAATASLPITNNKFDHLPFNYIDYFTLQQCSLLLGSAPVTSTDLLKLAQSANLLYSAAVTTPTTNPETALSDKIPFTSKIDQCRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0E6</accession>
    <name>A0A183I0E6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13208</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040088">
        <property type="protein sequence ID" value="VDP13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0E6"/>
    <dbReference type="STRING" id="387005.A0A183I0E6"/>
    <dbReference type="WBParaSite" id="OFLC_0001320901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001320901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001320901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP13170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001320901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17297" checksum="8B7486CE37503CEF" modified="2016-09-07" version="1">MAKGVRVLSEEIHLWEIFSDFSCKIVTYADPGENIDIENFCTRNAMGIYIEIERFEEVLYYMKNSTIHVNVNNSINRTPVSIINHLAVFSKSSLGLKIKAYGSMVACDDPVCRYEWFHYGCVNVIEKPKGKWFCPECAPKHSTSEMSGIGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I165</accession>
    <name>A0A183I165_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13477</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040221">
        <property type="protein sequence ID" value="VDP13865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I165"/>
    <dbReference type="WBParaSite" id="OFLC_0001347801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001347801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001347801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552721" evidence="1">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001347801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27067" checksum="C889246B1F8C093E" modified="2016-09-07" version="1">MLAIMKIFSFVLLPVESVPISERKRDSSDYDELIAVVESEKHLLQQQIAVVKSASSSDFSSEDNSDLNSTVAYHKSYTMNDNADKVYLNSSREDIRNISKHQFREILEGMLQKHLELARKRIAYSNIFTNNNSYANSTLGCHIFCQFLSFCIIICGVCLLWACTCCAQPRSIDPSGTDSLSGVNLANIPAPIDYSKPYMIKCDARGSCYASPLDDDEVPPLPSYDKALTCPTHPSPKTQQLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I171</accession>
    <name>A0A183I171_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small integral membrane protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13483</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040224">
        <property type="protein sequence ID" value="VDP13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I171"/>
    <dbReference type="WBParaSite" id="OFLC_0001348401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001348401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001348401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027877">
        <property type="entry name" value="Smim15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15086">
        <property type="entry name" value="UPF0542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001348401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7397" checksum="EC3E21E668F817AA" modified="2016-09-07" version="1">MFDNLKDYLLKRFIPLVLWVTDDPSSFFVTLLLCITPFLLLTVVLSWKLRKAIKVSFISHIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1F2</accession>
    <name>A0A183I1F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13564</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040268">
        <property type="protein sequence ID" value="VDP14081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1F2"/>
    <dbReference type="WBParaSite" id="OFLC_0001356501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001356501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001356501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552724" evidence="2">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001356501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13848" checksum="9D8DC5F8AABA0EA5" modified="2016-09-07" version="1">MLMVLLCIWVLVCGAIMASHYSYDSRETLIVAIILDALLMLTYATLVAIVVAVIVAWMITASATVDILATLTIGNAWHTVTCLMLDSMTQQYATDSGQVFYTQTSSTPTLTASSVAQNNRHVDTNDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I391</accession>
    <name>A0A183I391_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KASH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14203</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040670">
        <property type="protein sequence ID" value="VDP15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I391"/>
    <dbReference type="STRING" id="387005.A0A183I391"/>
    <dbReference type="WBParaSite" id="OFLC_0001421101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001421101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001421101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552757" evidence="2">
        <location>
            <begin position="16"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001421101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="525" mass="60406" checksum="DAB0498D43716B23" modified="2016-09-07" version="1">MVSVYFFSFIFHAGALSPLHTRRGPLNDLVTPTPDFAEFNYLEECPKLLAVTSDDDCQNVAVAFSDLDKLQIELEQILVHTTDHQKKIYGEITFLTTGDYPSDDISNRLMPVYELKTSESLPSCSKEIEREPIMEDLCTDGEINWLDESFDVWPPINLSQKFWVFAREYLDPVDEEYLQQWWSNIVHLFINDDISKSTSQLCPPTEKKITNCDTLLHDHKTSSLPSYSKWDISTSLHRNKSFISTKNISSSIRLKLLNNDSSPPPNKIARYEKRSPSQSSGKTVSLLDDLISAYVGGKSDNLDNHYNGMLPKLDKKNCSKKDSLVQLESNDWIIKNEEAEREDILRVAHSNGLATEGNGSASCGDTLEMLNYALADYLSKFDKELDTNKCSKVIQEIIGPEDVEELVRKCASGKKHNSEDEVSAALKKLQVELTEKVIPWRSMVAKIWHRLLAEYLRVKLEQTLDKADQEMFEVYDKYYSEFPRRRPMNVQEREECRCVLQRRNDVAQAYYGKEYAALSKWKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3H8</accession>
    <name>A0A183I3H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRO8NT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040741">
        <property type="protein sequence ID" value="VDP16354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3H8"/>
    <dbReference type="STRING" id="387005.A0A183I3H8"/>
    <dbReference type="WBParaSite" id="OFLC_0001429801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001429801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001429801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRO8NT" evidence="2">
        <location>
            <begin position="72"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001429801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45124" checksum="7AC0C4E43CF9F7AC" modified="2016-09-07" version="1">MSLPASPAFVNITSQSGTFFQPPTQPQSGGHHAGPPQMLPENILEEKARKWKQLQSKRYAEKRKFGFVDSQKEDMPPEHVRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVKVLYHITGAITFVNEIPRVIEPVYMAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEPIQMELDQDEDKTVAEWFYDHKPLSTTRFVNGTTYRRWAFSIPMMATLYRLANQLLTDLVDDNYFYLFDLKSFFTAKALNVAIPGGPKFEPLVKDLNALDEDWNEFNDINKVIIRAPIRTEYRIAFPFMYNNLINSLPVQVSWYHTPSVVFIKTEDPDLPAFYYDPLINPIAQLSAEKVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I407</accession>
    <name>A0A183I407_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SF4 helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14474</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040886">
        <property type="protein sequence ID" value="VDP17216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I407"/>
    <dbReference type="STRING" id="387005.A0A183I407"/>
    <dbReference type="WBParaSite" id="OFLC_0001447701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001447701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001447701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001447701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23940" checksum="0FDACA64FA0D5045" modified="2016-09-07" version="1">MHIYGAACTLPLYKVEHHPAVELWIDRFERTKGELIIMKADEFRDRSVTQIANAIRNQVVAGAIEHVVIDNLQFLVGLAILNDETANSFERFHQQDRFIGLMRSIATDCMTHITMVVHPRKTNSGEDLDIHHFGGSGRVTQEADNIFAIQRRRDEVDRRRFRKFLYILKNRYGQRKVEDDTIEMIFQPATYTHALVDLSTGPVSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4S7</accession>
    <name>A0A183I4S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14739</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041143">
        <property type="protein sequence ID" value="VDP18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4S7"/>
    <dbReference type="WBParaSite" id="OFLC_0001475001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001475001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001475001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF11">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001475001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7969" checksum="97A1DB012E87EA70" modified="2016-09-07" version="1">MCRMPIEGDDPQLGNVYFQDGRRPKELVWSCNYDEYCCGYDCCWRGAASSYWNRKFGDVLLVAVAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I653</accession>
    <name>A0A183I653_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041783">
        <property type="protein sequence ID" value="VDP20880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I653"/>
    <dbReference type="WBParaSite" id="OFLC_0001522601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001522601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001522601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001522601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8837" checksum="3940B96BA21412AD" modified="2016-09-07" version="1">MISKKQAINCDKEKEAYLGIGCDRSNVNVQRHTAIIDNTEVFVELDTMMMDGRIAAKTSSKQCLPLLSTANNNFACPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6C4</accession>
    <name>A0A183I6C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15286</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041888">
        <property type="protein sequence ID" value="VDP21168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6C4"/>
    <dbReference type="STRING" id="387005.A0A183I6C4"/>
    <dbReference type="WBParaSite" id="OFLC_0001529701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001529701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001529701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001529701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11888" checksum="C5DB6FD2AA2BA2F2" modified="2016-09-07" version="1">MNGIGLSSFSRDCPAYHLSYGNYTFTALAVDISCQKRTLLRALPQNRKLWLPVNDDRWFHEPTFVALFGWKQYVFVVYNEESHEGVKVSRKSKLINVNCVSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6R2</accession>
    <name>A0A183I6R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15424</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042117">
        <property type="protein sequence ID" value="VDP21810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6R2"/>
    <dbReference type="STRING" id="387005.A0A183I6R2"/>
    <dbReference type="WBParaSite" id="OFLC_0001543501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001543501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001543501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001543501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24918" checksum="6B4D76D6563AFA12" modified="2016-09-07" version="1">MYPVRPTKPISLFENNNSNCIPPIWSQNFTSFHPIFPLLSQTSSLFAERTTSKNIPSLLPSVSSLPSFLPTDPFMSTVTPFSVTLIRGDKLETINLRLQLTSNENVIEDILSTREHCDNVVLLCFSRAGQYFHVVFCSAPDGLNIGDQFNMPAKWQSLCKEANIKKANIRNGIVIRNIEFGEEIIICNEVEALLLEPSKMLQNDKQGQQLEMKQQKLNETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V6</accession>
    <name>A0A183I6V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15468</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042196">
        <property type="protein sequence ID" value="VDP22016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V6"/>
    <dbReference type="WBParaSite" id="OFLC_0001547901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001547901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001547901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001547901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12352" checksum="9517667099B8474D" modified="2016-09-07" version="1">MSTESLYAAVNEVLKKLVAEAIAAEKCMKIVNRTTGKKITSEKMDEILVSAKEELQESVLEGVSQVIHNDEVLEGMVKLKNLIEGSPKEVKGMISTLSKGTKYMTHVTLIADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I730</accession>
    <name>A0A183I730_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15542</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042331">
        <property type="protein sequence ID" value="VDP22456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I730"/>
    <dbReference type="WBParaSite" id="OFLC_0001555501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001555501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001555501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001555501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15986" checksum="4969928E66A4CD94" modified="2016-09-07" version="1">MTEWHQVSHKPFLNEEESLDVIPRSQIIRVPIMEQEEAHEEESLGPKVFHALVVESLPVQYQQLLVTHTVIRNTEGLARIERGMCPKEFRTLKGWRIHAISKMMHENNTTFIQVKNKRYIVNSIAIFTPMFVTRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7V3</accession>
    <name>A0A183I7V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15815</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042949">
        <property type="protein sequence ID" value="VDP24063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7V3"/>
    <dbReference type="WBParaSite" id="OFLC_0001582801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001582801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001582801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001582801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9862" checksum="E2E64D08A7B24559" modified="2016-09-07" version="1">MKKKKIIINNDLNIYHFPIKCRIDEETGEESWRVLYGDPRSSSFATLAALVKYYKIYSYMDPKTGAIDTFPIWKTVESDSDEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8L8</accession>
    <name>A0A183I8L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043976">
        <property type="protein sequence ID" value="VDP26910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8L8"/>
    <dbReference type="WBParaSite" id="OFLC_0001609301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001609301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001609301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001609301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12846" checksum="6FD3C097B1AEED0D" modified="2016-09-07" version="1">MVNTTGNFDVHLSNYIEFLEENSSKSISSAPVPGIWSGPDYHEMNISHNKQLQRDEVCSNTLGVITKKYTFCAIPEVTVCAAAPKLSKPVEIALSSAFRPVIVNKEKVSLSMKYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UIV2</accession>
    <name>A0A3P7UIV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001861">
        <property type="protein sequence ID" value="VDO34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H668"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF1">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="280" mass="31737" checksum="BC1069693BA6D34D" modified="2026-01-28" version="1">MISLFVLFVVTVSYVESIGENPMDVNAIASIIGGISNIMQNNVETIDVPSSQIMGRWYQVYKAAIAFDVYRTDMFCPVAYFKPNSVMGEDGFSIEEAYRVITKNGPIETYKRDLNKVGTGQYWMYTEEYFYPRQFNIISVGPNYTNTTDGTEEEKQYQYMVVTDGNRLSLSVYARHPMIFYQKYNEEVVKFLEHAGFGGKVFWNSPKPIYQGADCEWPSEKEVFARRVLKNQEIAKNGGLDTAAKSGSFDGSPQATDVRSSITEILQNPQLALQKLVQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WK03</accession>
    <name>A0A3P7WK03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004688">
        <property type="protein sequence ID" value="VDO43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WK03"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="257" mass="28475" checksum="AF119290B5DD0A39" modified="2019-02-13" version="1">MKKLARKVFCRILENDFVQLTNGDKLAVGSKVSNNDVNVNGLCFQCYNLQKQLSDLSYRLKQATEEIKNRTANEELRKETENIDDIEKSIGNSFEMLDDTISVKNKDAASDDSIIKVENKGTSISLEDGIEMHWCNNTACSPIPGPNQYSIGIATAKLQASPSRDVATDSPDQELRTVRPVRHFECGTEPVLTRDYGCGNDMFAMTCDFSTMTDAVELVDSGTECKPTNSLLKDSSSMTAPITSNSCHIQTEHIKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BXQ5</accession>
    <name>A0A3P8BXQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018043">
        <property type="protein sequence ID" value="VDO81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BXQ5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="133" mass="14180" checksum="5391047A8E06F91A" modified="2019-02-13" version="1">MENHNANASSSGETTGIGGVRLITSSTSGAGHLAGLGKRRNVKLSMHSRSITSSGTDLITGTANIPNNTNRNNNNNNTNNSNNNSTNSSHSLIGSNDTFIHAPLQAVSLLLNFKYYLNFHSLKIKLAMEIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F364</accession>
    <name>A0A3P8F364_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040727">
        <property type="protein sequence ID" value="VDP16263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8F364"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055402">
        <property type="entry name" value="KNTC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24506">
        <property type="entry name" value="KNTC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="2">
        <location>
            <begin position="187"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="790" mass="92156" checksum="70312F37888867B9" modified="2019-02-13" version="1">MSSEQNARITLLDLSAEILDKALDEFYSSDASGIVRIRHLIHRDKHTSCIISQFIMALTTDGKLLIWDATTTMLISSIILLKTNEIAKDFMLFDDIPDREGKMNENTKLILLFTNHKGVNQLQIRNFRTCDVIYTKIVNNTTFLLDKITREEGLILFIQLFAYESSELNAVKVHAIYECQPDMRLDHLINQQRWVEAEEFAQLFSLNMEKIYIARIEHFVDTGSVGQIDLETHELDEFLGWMMEVSDQNWVAEMCIATIIYCSSHSWVKKILDFVKKLEITDNETKEKLSLMRYNYQSYREVLGPWRKPCSSKFPGIDLWSEFLGDCSWEHIFEIFYKNGQFSEARLIWYRYRKTLEEWIKEKGNFERLLTEIHLTIRDAIGDIMEAMCFLEEDIIPVVILNDPKTCCACCKTFLLDVARVAETEYPEYFPENSLKIASTMERVIENLLSCSITPCRQAEVAFTLSVIGCYSEDPDDLMGELNIYVRNLRSMERLKSVYQCTMSYNTYQEQTVESICYIIVERVKSVQLIKSNIDQYARPYMNEFKLDPDRTLYNYILKIATSSTGVVSSSNPWDERCLAIAESISNLDLRCEALIDVAKRAHPPWTKQLSNAVQAMLRAPGLDFKMVSRLQQQCDFATLGERWVQYRLPMQTLERYLQQKHLFSKAIEFIFRQESVEADPQRRLTSALEIIKLAGKLKKNLMERHECVFLFCLYLINAKLIDELFMGVISYLNELNEMDRNRVINQLMAHIEALLNCPVLLLTEKAKEIRLRTIEAVSCILERFRKVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ19</accession>
    <name>A0A183GZ19_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Trehalase</fullName>
            <ecNumber evidence="2 6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS479</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 6"/>
    <dbReference type="EMBL" id="UZAJ01000159">
        <property type="protein sequence ID" value="VDO25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ19"/>
    <dbReference type="STRING" id="387005.A0A183GZ19"/>
    <dbReference type="WBParaSite" id="OFLC_0000047801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000047801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000047801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF3">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552314" description="Trehalase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000047801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="618" mass="71451" checksum="FF510A9585D79369" modified="2016-09-07" version="1">MEGLICIIFFFFVNGPRGLCTGLLAAPNKHKTAVSHHLFLYFPKLYVPMSFVFSDTLNNEVLVVADMPLEPNCSQPICLGPLSQIYCSGRLIHTTWLFGMQETCPGNMMRKSPALVLELFTNLTYPLKREQFQKFCTENFANISYLKQATLVDWTREPENIRRLQDTKLKKFARKLNELWKVLAREFVEKVHKTPELFPILPVSNAFIVPGGSFQIYFYWDSYWINKGLLFSNMSTTVRQILENLASVVQFHGFIPNSGIVQLSRRSHPPLFTQMVADYYDITGNKTLLKEMTPWLDQEMLWWEKNRTLDVKLPSGRKYRMYQYRALSNCPRPENYLIDLNNGIYGTGYPEFIWSSIASACESGIDFSTRWFAHQGKYAETKYSIRTNDIIPVDLNVFMAWNFATLANFHEILGRSKKADEYRKLYMNLRKAVDEVFWSESDGAWFDYDLMEQKRRSGFYPSNVFPLLLSGYGARITKKVLDYLLGSGVLDFKGGIPVSLNKASQEQWDYPNGWPPLTHLFVESLRLSRDEKLVKIAEKVAWKFIRTAYNGMMNPKKGMPAACWEKYDIRYDDGRPGSGGEYPVQQGFGWTNGALLDLIYKYGIRKQYVVSASNLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H024</accession>
    <name>A0A183H024_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS834</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000333">
        <property type="protein sequence ID" value="VDO27268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H024"/>
    <dbReference type="STRING" id="387005.A0A183H024"/>
    <dbReference type="WBParaSite" id="OFLC_0000083301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000083301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000083301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF15">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0868">Chloride</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000083301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15680" checksum="D1A73286D3F9A741" modified="2016-09-07" version="1">MVKDVIYITKSTTYRELREILHFAPTLKSFPVVTDRKDKILLGSVAKKYLIVMIRRHLFDAEFNLVSNRKTPGEIFNSIKRYSMLLPKKQRSHSAGRHSLGKNGERLLVPNANEKLSNEGSITGNTLLSISPLHAPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H077</accession>
    <name>A0A183H077_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000362">
        <property type="protein sequence ID" value="VDO27465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H077"/>
    <dbReference type="STRING" id="387005.A0A183H077"/>
    <dbReference type="WBParaSite" id="OFLC_0000088601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000088601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000088601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000088601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12375" checksum="D4B403A75C662CCD" modified="2016-09-07" version="1">GQIIFSDLSDEEEDEQLRAQADSVISRLNDWGTKNPVTRQADALSRLVGSAPLVTPVLDRLLPSDPWFFSMDMKNHSTVDSNDTASPHMTWLASAANHPRSLKTTITISKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0A0</accession>
    <name>A0A183H0A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS910</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000370">
        <property type="protein sequence ID" value="VDO27538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0A0"/>
    <dbReference type="STRING" id="387005.A0A183H0A0"/>
    <dbReference type="WBParaSite" id="OFLC_0000090901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000090901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000090901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="251"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000090901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47039" checksum="37E0054CEED50086" modified="2016-09-07" version="1">MPCKVYGSPKSFRVQKILVAAKIGNKDVIVQDQKPPHNKFPLGMTPAMEDNSFTLFGADAIMLHLASESMKSANCSEVLQWMQWSEGQLIPNVLSYVLPSVSAARIDNECFNELLLTKTFLVGERMSLADISVALDLLPAYQYVLDEAARAPLNNVNRWFKTIINQKPVKDIIGEVQFAIKVSKFDNTKFRELFAKLPKEHADHKDGKNREQHGKGNKEQQKEDKKTKQTKKEDDDEPDATDEVLAQEPKSIDPFAAMPKGSFVMDSFKRVYSNEDTATKAIPYFWENFDSENYSIWFAEYKYPEDLTLTFMSCNLISGMFQRLEKLKKNAFASVCLFGTDNSSTISGIWIWRGHELAFKLSPDWQVDYESYDWKKLDPVDEKTKKIVNEYLMWEGDFDGKIFNQGKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V9</accession>
    <name>A0A183H0V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1118</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000481">
        <property type="protein sequence ID" value="VDO28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V9"/>
    <dbReference type="STRING" id="387005.A0A183H0V9"/>
    <dbReference type="WBParaSite" id="OFLC_0000111801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF23">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39789" checksum="3249F35E979403D4" modified="2016-09-07" version="1">MLDYFRNKSIFIYLIISLQLLCITALPITPVLAFVKRWLFGALLCKLVPLCQGISGNYCLCFIAVDRYRSIVMPTREPWTTYHAYLLMAISWLTSATVSSPLFVTQRLQPLALENITLCGYVRTKKLQKFKKRHIFGLQFCGEYNWPEDNRIKLFYGSMLLVCQYLIPAIIMTFCYWKILQKVRADWIVAQHSMLTAAQQAQTAVRKRRVMYVLILMVVVFMASWLPLTIVNIFRDFGIEAFLDIQMYFKLLNVHAIAMTSIVWNPLLYFWMSKRHRKTFKEDMIGAANFRRGTLTDPTCITAETAFAHMHANCFLLVPLLPLYQSSLNQKIQLTTRISRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Y2</accession>
    <name>A0A183H2Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1842</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000952">
        <property type="protein sequence ID" value="VDO30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Y2"/>
    <dbReference type="STRING" id="387005.A0A183H2Y2"/>
    <dbReference type="WBParaSite" id="OFLC_0000184101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000184101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000184101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000184101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20509" checksum="AED2EA0F5E16893F" modified="2016-09-07" version="1">MQESFLVWDPKAYFKKGRERQLAEINVCEHVEGDSSKFALRQGNEPNTEMRTELKAASEQCKVHWVKKIRELMQGLMTANFDMRQVPARNSGTTTTTSISDRTSKDSDSLPTSNEDRNSLRSCTSSTSEELKVQVGTTSSCMLVNVLYISLKAIINCGLKVNMSCPSLVLLLMQFYALVIVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3W0</accession>
    <name>A0A183H3W0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS2170</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001191">
        <property type="protein sequence ID" value="VDO32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3W0"/>
    <dbReference type="STRING" id="387005.A0A183H3W0"/>
    <dbReference type="WBParaSite" id="OFLC_0000216901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000216901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000216901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000216901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23434" checksum="2468D54175D0C5DA" modified="2016-09-07" version="1">MAGRTTVRSGNTGGPNKTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFTKAKNWVKELQRQASPNIVIALSGNKADLANKRVVEYEEAQAYAEDNALLFMETSAKTAMNVNDIFLVIAKKLPKGDGSGGGPSGRGHEGIDIGQDGQGQNVSSGLCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4W6</accession>
    <name>A0A183H4W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2526</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001471">
        <property type="protein sequence ID" value="VDO33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4W6"/>
    <dbReference type="STRING" id="387005.A0A183H4W6"/>
    <dbReference type="WBParaSite" id="OFLC_0000252501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000252501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000252501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000252501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11846" checksum="190BBCBF52C39ED5" modified="2016-09-07" version="1">MISDLLATKEIWALPRPHDRIRIEPAPPPLYMNTKVKVDTASSGELLAIYLPHWKRIKKKSLERVLSDSRPTISKKHQIVKYCIQYESTKQHHMNMIFPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5I4</accession>
    <name>A0A183H5I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2744</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001651">
        <property type="protein sequence ID" value="VDO34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5I4"/>
    <dbReference type="STRING" id="387005.A0A183H5I4"/>
    <dbReference type="WBParaSite" id="OFLC_0000274301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000274301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000274301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000274301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12527" checksum="FE6967A890CEC230" modified="2016-09-07" version="1">MGAPPPSPPSPKYYQAVPPDCQLLPLGPPSGRAQQAVDQFANFTLALPEMKLNDIGSNLNDEQVQMRRAAFFAIVVSTAAVIASIVTLPMLYSFAQSFQSHLIAETDFCKVRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H647</accession>
    <name>A0A183H647_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2956</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001842">
        <property type="protein sequence ID" value="VDO34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H647"/>
    <dbReference type="STRING" id="387005.A0A183H647"/>
    <dbReference type="WBParaSite" id="OFLC_0000295701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000295701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000295701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF175">
        <property type="entry name" value="IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN C27B7.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000295701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26850" checksum="0E17604B214034C4" modified="2016-09-07" version="1">MEHGGLYESTNFSCVAENEAGPTSPERIRYQIHGNNVDLQWEPPRITNGLLKDYEILYTDNPNLPEEDWEVAKAGSPDAPRPPVVTITPAEKIVKEPSNEELVFECEALGVPRPKILWLWSGGLVEDGKNEFRIYDVTPPDAQDQSNSKLISEKTNRAGVATCQAVNAHGSDEKRTEVKIVGPGSPPRDISTVPFTNSFKVSWNPPKYPNGKITVSICIYFCLQQKISKNLQCKLVLFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H680</accession>
    <name>A0A183H680_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2991</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001871">
        <property type="protein sequence ID" value="VDO34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H680"/>
    <dbReference type="WBParaSite" id="OFLC_0000299001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000299001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000299001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000299001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16682" checksum="A426EA6C1B64FDD5" modified="2016-09-07" version="1">MTNSCTCLNPNKAYGISRRIIFRGGFDRTKETYSRRNQRDRSHNTILCLSADSCGIASYRTRTHIQPYSVNASMHATHAHMDGEGKCKMHEMSSWTRKCVTGMGIGDMSLPPPTRMSYVWTDEYGMVYTLLESFFIENEDPVVRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6F5</accession>
    <name>A0A183H6F5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3065</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001932">
        <property type="protein sequence ID" value="VDO35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6F5"/>
    <dbReference type="STRING" id="387005.A0A183H6F5"/>
    <dbReference type="WBParaSite" id="OFLC_0000306501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000306501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000306501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF125">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="46"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000306501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39756" checksum="0F12D14C2E3B599D" modified="2016-09-07" version="1">MEKENEKLITSSTEHGASARKHHEISLFKFQWEHVSTPLAIAFWFFTVTIMKIIFHRFQSVHSLLPDSALLIVLGLFFGYVFHLVYPDEQMYLKPDWFFLYLLPPIALDAGYFMPNKNFFRNFGTIMTYAVLGTLWNVFAIGLTLYFLHDYFKVHTSLIELLLFSTLISAVDPVAVLCVFEEIHVNQLLYICVFGESLLNDAVTIVLYQTLNAMVDEHGLTGADYVIAISSFFVVSIGGLLIGLMWAIFTGFTTKHSQHLNVVQPLICLLFPYLAYLTAEMVAMSGILAIVICGLAMKQFVVGNLSRKSLVTVQYFMKTLSSSCEALIFVYLGISAVSKNHDWDAVFIVGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6H9</accession>
    <name>A0A183H6H9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3091</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001958">
        <property type="protein sequence ID" value="VDO35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6H9"/>
    <dbReference type="STRING" id="387005.A0A183H6H9"/>
    <dbReference type="WBParaSite" id="OFLC_0000309001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000309001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000309001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000309001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55421" checksum="0F3F9A66C58BF33D" modified="2016-09-07" version="1">MSTNGGSLEDCHTNVFALTELNGLKWKCLTTPLSQRTWTSLEQDPVLSAYAKCLQAGILCAWRRQPPQPTSTLTAMQLPDYRIDVVKELWIFWYSHEEPDCLTEYTSHLACAEDGQGNWSVPGIQYETRTLFFKALHNLIERNMLKNGYIRIGKYFTRPYEVPSSDRIHCSPNYVNGISFNFFVHGENIVCATVCVQRQPTLFRLSRRHLDLGKKQSVILGPWSMRAILLPEQPRIVDSTTSVLQQQPLTPECDSFTNSSTAYASSYREPLSSVAHQVNPAPSSSIESETVNSNNEDNAGTISKAAVDKLWSEWLQFFCLIVNVERNLSSADTVGYIGYTENASSTKSSLPKMVLVDVDGVHMWYPSSLIVVQASDDLLMRQNEKTANESSSDFFNSRTNSRSFTPRTPPTTRLRSSPSFRKRKKRLSECDVEASAEWHNAMYGTMVNGARAAQRFFEESFIAPANSRRKENSESPSSSGLGLLLSSATSDDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6R0</accession>
    <name>A0A183H6R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3172</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002043">
        <property type="protein sequence ID" value="VDO35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6R0"/>
    <dbReference type="STRING" id="387005.A0A183H6R0"/>
    <dbReference type="WBParaSite" id="OFLC_0000317101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000317101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000317101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rtel1 helicase ARCH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000317101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24053" checksum="80C551899B2F81DF" modified="2016-09-07" version="1">DNTVVPFGAEIQETNEIKIEKNDVAYLLACLHQFEDAVDVCMKDVGEKVLGIGGKIYSGEKMIELLSKAGFRKDMREAISLIIDKIGQYLTAKAQNESAGEFVDKGIYLQEFSSFISTIYADKYALLRVLDSSMGALRNMDKKVEDKNSAKYFQLYVTEQSSVITLNYWCFSPSVAMWLIFERLPKLNSIPDNINFLQYKMRSTHNLEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6S1</accession>
    <name>A0A183H6S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3181</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002050">
        <property type="protein sequence ID" value="VDO35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6S1"/>
    <dbReference type="STRING" id="387005.A0A183H6S1"/>
    <dbReference type="WBParaSite" id="OFLC_0000318201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000318201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000318201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000018">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF71">
        <property type="entry name" value="CCCH-TYPE ZINC FINGER PROTEIN MOE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000318201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31759" checksum="49DFE33ADF0AF2A9" modified="2016-09-07" version="1">MVMCQAWLESGICNFAENCRFAHGEEELRPCKYVFVLIYCYYNIYQYNFSLFYAIFCRSPTKNPKYKTKLCDKYTMAGLCPYGDRCLFIHPEASNASNPYIRPDRYLKMQRERALLASINNVSSEAPEISLSNHATNRPPPSWPLESPAFFSAHRDLDQLLKLQYFTENMKPLSKDPEDVLAAKNLDHTLVLSDITNQTMLSVQATPNTVFSANNSKVDVVTRDSPDSGISFHDHEEFVLRETITPQSDALISSDYPFQFAIHADNLARSLACEFKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7G9</accession>
    <name>A0A183H7G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002285">
        <property type="protein sequence ID" value="VDO36464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7G9"/>
    <dbReference type="WBParaSite" id="OFLC_0000343001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000343001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000343001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000343001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9232" checksum="80D93EE93877DDEC" modified="2016-09-07" version="1">MYWGVKLEENSKWITNSLAGLLIILANVRKREGHLEISEDRSGETEGYCITFFHNFFALSPLFCSDCFSFGISRGTNFPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7J6</accession>
    <name>A0A183H7J6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS3459</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01002313">
        <property type="protein sequence ID" value="VDO36563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7J6"/>
    <dbReference type="STRING" id="387005.A0A183H7J6"/>
    <dbReference type="WBParaSite" id="OFLC_0000345701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000345701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000345701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO36563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000345701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21306" checksum="E6D3726ED4E3DD71" modified="2016-09-07" version="1">MFHQQNYQTNQALPFSWPFGSSDHTLRIKKIGEALSQNEYDIVALQEIWKERDFLRLREALKETYIYSYYFHSGFTGSGICVFSRYPIVSTLMHRFTLNGFAHHIHRGDWFGGKGVGLVEIEIEQYRINFYAAHLHAEYDPNKDLYLPHRLAQAFELAQFVKHTSNSADALILAGLFSPTVNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H834</accession>
    <name>A0A183H834_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pan3_PK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3648</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002518">
        <property type="protein sequence ID" value="VDO37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H834"/>
    <dbReference type="STRING" id="387005.A0A183H834"/>
    <dbReference type="WBParaSite" id="OFLC_0000364501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000364501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000364501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="7">
        <location>
            <begin position="159"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000364501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35220" checksum="CCF5CEBDB1D5E688" modified="2016-09-07" version="1">MFLCSSKLGSIANLPGGGQVVQESLMWSYIVQLSSALRAIHSAGMAARTVDPSKIIVFDKTKQVFLTSDIFMVLKVMLSSCGILDVINPGNDHTIQLYQQDDLNGLGRVLIALAMGSLHAIRRENISNSISIISQQCTTDLKNIITLLLQASTQRPHSINEVMPMIGARFYAQLETTQMKNDLLENELSKELENGRLFRLLCKLNTITERAEFQMDMSWSETGDRYLLKLFRDYLFHQITETGKPWIDMAHIVTSLNKLDAGVNEKIQLVSRDGENVLVVSYTDLRRCLENAFTELQNRLPSIPNPLLPVVGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8T4</accession>
    <name>A0A183H8T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XK-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3896</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002764">
        <property type="protein sequence ID" value="VDO38131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8T4"/>
    <dbReference type="WBParaSite" id="OFLC_0000389501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000389501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000389501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053291">
        <property type="entry name" value="Ommatidial_diff-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF20">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000389501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20616" checksum="3F3C2BC3D70CC75B" modified="2016-09-07" version="1">MPCSFRARVNQLWSIWYTVTMLLLQIYLIYLGFERYQLYSEMKWPHGAYPSLWLTVYIILYSSCIPALLLFMAFGIFKSGNVAGDNDRLGARIDRIIEITRSSHECRKNGCSLLRSIKSLWQHAPPLPQLIHLLMALFQLFAQQMMLSQLYRYGFINSGKIKMPLKFKTWIYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H975</accession>
    <name>A0A183H975_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002916">
        <property type="protein sequence ID" value="VDO38669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H975"/>
    <dbReference type="STRING" id="387005.A0A183H975"/>
    <dbReference type="WBParaSite" id="OFLC_0000403601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000403601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000403601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000403601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19328" checksum="761BA104F01AD5B5" modified="2016-09-07" version="1">MRRNIPVINNIRYENDRKHIYETLCRHQISVNIKAQSRLYCYYKMDRPYLRLAPFKVEIVRQNPLIVLFHDIISDEEARIIEMLAVPKGLLLNCRLCRSGYRFVDVETSVVNCRIIELMQNPEEEECEGNGERYSGSIWIRFLAALVRNAMGSSCSIPCIGISNTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9A7</accession>
    <name>A0A183H9A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4071</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002953">
        <property type="protein sequence ID" value="VDO38770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9A7"/>
    <dbReference type="STRING" id="387005.A0A183H9A7"/>
    <dbReference type="WBParaSite" id="OFLC_0000406801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000406801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000406801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000406801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14691" checksum="1B462F573E2DB2DA" modified="2016-09-07" version="1">MYKVLRSYSKKAERKHELTRSAGSTTDKVNGYSAVDGSTVHSVSPSYGVGGSTIVEDVRNGQVVPIDRNGRIEAAWPSGQAFSESSSYEAREHFERKVQRVKKTRGERDSNRKSKKSKMSHSFTAAQVLHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9C3</accession>
    <name>A0A183H9C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4085</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002970">
        <property type="protein sequence ID" value="VDO38814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9C3"/>
    <dbReference type="STRING" id="387005.A0A183H9C3"/>
    <dbReference type="WBParaSite" id="OFLC_0000408401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000408401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000408401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="208"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO38814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000408401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60320" checksum="9A2D73ECBA457264" modified="2016-09-07" version="1">MIFLELLDTEVKYCHDLVQCYEVFAQGLRGIISTSLASQLFLNFEQLILVSTSIANALKQLPPGDVFVEKIDLLRAYVEFCSKQQTALEMLNELEHNNITFRQAYRSCCVKTKGINFSYFLLLPMNRITRYPLIFEKLVKYTDPGDPKRKNLEKAYELLKSLCTEINDVISAMDSSSMLIWAQQHIHCEAIQPPIVFPSSTRKVGPRCLLHSGALQKQLNGKILVALLFNDFLMLTTPVEPIEQLEEFRISKTSELQLNLYKTPLLLENAKVIQSKEMDDCSFEVRSGEFSVILRAPNRNARLFWIAQIEKAINDYHNQCLTVKKSSLSSDISEQGRLFVELVCILNMDAALRLLGTQSILCKFQIGQSSTYADVDMNKKEHLCTTQLPIYKTAYDDFFEVAIFLNRFFSPDLCSSRIAMADLLTAATMHRGPMSKQFDCESGDISNLRPRMLPGWPLISVGATIALFMAFALHHIEEGHVGVYYRVCIFTGIILQIFDAKLKLPFLFFFELSSKHYYYFCSIFLSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9E0</accession>
    <name>A0A183H9E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4102</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002991">
        <property type="protein sequence ID" value="VDO38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9E0"/>
    <dbReference type="STRING" id="387005.A0A183H9E0"/>
    <dbReference type="WBParaSite" id="OFLC_0000410101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000410101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000410101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000410101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13303" checksum="AAC70952FCF214D1" modified="2016-09-07" version="1">MATYELCCDMIDVTIDISSIYGCSDDLSCAVFDSQSSAVIHLRTDQVLFLRQVNMFLALVCIIRSENFEKQGLIDYNFQCFKGIQVKTKLDRISWDGEYVEYMFGMNFWIWKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAC2</accession>
    <name>A0A183HAC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HECT-type E3 ubiquitin transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4433</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003368">
        <property type="protein sequence ID" value="VDO39994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAC2"/>
    <dbReference type="STRING" id="387005.A0A183HAC2"/>
    <dbReference type="WBParaSite" id="OFLC_0000443301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000443301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000443301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000037">
        <property type="entry name" value="E3 ubiquitin-protein ligase nedd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO39994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000443301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46464" checksum="1459DE238E6C2D80" modified="2016-09-07" version="1">MSPSEAPGVLVYGLPDTEQDTELLRVRVVRAGGLSKRDIFGVCDPYAVVLLKREGSSAVTREPIWNEEFVFRVVREDCILTVQVFDERRITRDNFLGMVQIDLSLVRIPYEVVGVPVPEASYILSPRSHRFYSSVQGIICLSLSYVTNSTQPAAELISANDDSDWEQLSTSSLTNRQGSTSLPEGWEERQDANGRTFYVNHISRTTQWMRPTRSGTESELDETEQENALRRNYESRWQGSSEEHVEDNIANLEAGLRTKFESGGRVDPNDGRGLLPQGWDMQVAPNGRTFFIDHIHKTTTWIDPRDGQASATYLKEVRSDELGELPAGWEKRVHADGRIFYIDHNTRRTQWEDPRFENTNIAGPAVPYSRDYKCKYEYLRSHLPKSPTNMKCEITVRRIQLFEDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB32</accession>
    <name>A0A183HB32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NopRA1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4694</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003688">
        <property type="protein sequence ID" value="VDO40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB32"/>
    <dbReference type="STRING" id="387005.A0A183HB32"/>
    <dbReference type="WBParaSite" id="OFLC_0000469301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000469301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000469301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000469301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37714" checksum="7E7617A0BA85424C" modified="2016-09-07" version="1">MKPEMIVEIVDYVVGDDGPLNYVLTRSQEVMQAYGNVLGKLLAPKNLSTLQVAYNRVREDVLNCLNLLQTTEAEVYYSNSLMIEKKLMIYFNALYSLGIVKNSLIAMMGLSPSLFTFLMRETPIIEKQFIINHPGCHYALLYIIKTHSEKHENFVANSSLLIDKNSLSLVAEPATAKHTTMILNIVTKLLNVDDLLWAETRNLLVDWIHGFVFALTPDVLQHILDKPETIEMRAALLDSFVRHSLPKKTQLDNKSFCNPEVSVSHWCAAITSHRIRHFTLLRRLAVFNLVKNGRPKVTAKFVKRIFEQCQSDCQNKATGIWQATPPVLFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCW1</accession>
    <name>A0A183HCW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin-tyrosine ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5322</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004515">
        <property type="protein sequence ID" value="VDO42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCW1"/>
    <dbReference type="STRING" id="387005.A0A183HCW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000532201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000532201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000532201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF154">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000532201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29496" checksum="C9D7B60E297ABCE5" modified="2016-09-07" version="1">MPSTSTKSIDSISNLQKSRDENKAVKDAEKLHHANGHSNVSYSYSLLGYVEAVAQNFTIDTSRAKTNKHIVSICASKLGMHEYPDGRDDGNACDIYWQNNINHDIRSIIKNPQCKINKFPGMSDLSKKISLTRAISSMRRLFPDEYTFYPSSWFIPAQLDAFIKHCNKFAKSPNNSVSFENNKNWYIVKPDDGAQGTGIYLIQKPEQIRKPETCQLIQEYITDPYLLKDNLKFDFRIYAVIKSINPLSIYVAREELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE42</accession>
    <name>A0A183HE42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5756</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005117">
        <property type="protein sequence ID" value="VDO44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE42"/>
    <dbReference type="STRING" id="387005.A0A183HE42"/>
    <dbReference type="WBParaSite" id="OFLC_0000575301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000575301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000575301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000575301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40021" checksum="C9138647B537ACCE" modified="2016-09-07" version="1">MPLDEQGKPVVPYDASGTPLIHLASDGMTPLTEEEYQYSLQWNDYYNRYYKNTAEQKASNSSQSMTQSIVANDTYEQKAKNMKLLKKVRPEDIDLPPCVPPPPSTQPPVQVSDGPALSGEVEKKATPDPALKAKTKRMIEMQLKFSRKKLHDTVHSSVAAMPSSEMINTSAKHAPLPQQPNDSPENIDKLESPKECPPPPPPMHALIRNPSISAEGDSNIVIRESLNVALGDTPKSLDSKTLEKLKRISSDDAEIKGQATISQTELTPVILDVSDSVIKASGDRAKNFENPKLFSNLCKNSDEFQVGNQVFEKEVTAKSNDFSGSKDGKVQPELILTNVAVGMDIVLEQSPVKENNEEEKVLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE53</accession>
    <name>A0A183HE53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5766</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005131">
        <property type="protein sequence ID" value="VDO44250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE53"/>
    <dbReference type="STRING" id="387005.A0A183HE53"/>
    <dbReference type="WBParaSite" id="OFLC_0000576401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000576401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000576401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="3">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="2">
        <location>
            <begin position="270"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO44250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000576401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39308" checksum="1F66DAF74C615916" modified="2016-09-07" version="1">MSLSEIPEGELRSRFLTVGLADKTVRIISLDPQDCLSPLSMQALPSEPESIIVLEMFGTEAQSASTVHLNIGLQNGCLLRTTVDQVTGELTDNRTRYLGTKSVKLFRVRIQNKDAIMAASSRAWLLYDYQSRFHLTPLSYAALEYAAGFSSEQCPEGIVAIAENTLRILSLEKLGAVFNHVVHPLDYTPRRMIVHKASGNLIIIENDHAAFTVKGKMERRKQLADELMEVAKEAEEADQQAVKEMADAIRTEKVDERVYGSPKNQKGKWASTVRVMRSSDGETLSHFPFAEDEAAFSIAMVQFQNQSDTQFVLVGCGCELQLKPRKANGGCIYTFLLAANGTTLHLLHRTPTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEC3</accession>
    <name>A0A183HEC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005235">
        <property type="protein sequence ID" value="VDO44502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEC3"/>
    <dbReference type="STRING" id="387005.A0A183HEC3"/>
    <dbReference type="WBParaSite" id="OFLC_0000583401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000583401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000583401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000583401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19020" checksum="EA105163D5441ED5" modified="2016-09-07" version="1">MSNRVTIIDKNITRQLEYEIFSYGKLAACGPYKELLEKSENFLKFIEACQTESEKEENSKSESESSGSIVIDDDNSQLHGCEEAYDIEEVNEGSFVRFGRRISTLSTLDRRSSRSYHRSSQVKSFPEYSNDQLSNEDKEKKAKLIEIEKIEVGRTGRGLWLSKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF83</accession>
    <name>A0A183HF83_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6145</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005687">
        <property type="protein sequence ID" value="VDO45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF83"/>
    <dbReference type="STRING" id="387005.A0A183HF83"/>
    <dbReference type="WBParaSite" id="OFLC_0000614401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000614401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000614401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000614401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19756" checksum="9AA508A7456B9249" modified="2016-09-07" version="1">MGKNSRMNARNHQFQLTVDEHQVRDAISTVFHTILLHRSVPKMHYTSEINFQLGSIGVEEVDCNTLNLSYVRVNSSKLVSCLHEEIDAFVQCIRHSIESVTAPRFYSPPPVSLLTHYGTPLLNAKLVLVLLFSENKIILKKFSYILYIYIYIYIYICSEKLIFKTCIGFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFW7</accession>
    <name>A0A183HFW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6379</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006026">
        <property type="protein sequence ID" value="VDO46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFW7"/>
    <dbReference type="STRING" id="387005.A0A183HFW7"/>
    <dbReference type="WBParaSite" id="OFLC_0000637801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000637801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000637801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000637801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17068" checksum="4388E185F746FCD0" modified="2016-09-07" version="1">MYAAYLGHEAVCVLLLKSGALVDLCNASGQTALMLAATCGNLAVVRLLMRKDAEIDKQDNMGDTALAYATACSQASIAEALLDNGANPNIPNLLGMTPTLTACCIGHELTLLALLQNDGDPKLKNAKGEDGEALAFDNPKTIAILKDPPRVHILNFIIFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG70</accession>
    <name>A0A183HG70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6483</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006181">
        <property type="protein sequence ID" value="VDO46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG70"/>
    <dbReference type="WBParaSite" id="OFLC_0000648101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000648101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000648101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000648101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11094" checksum="286AE3C4E7F8F75D" modified="2016-09-07" version="1">MSSITTPFSDLGISLGAPYRLGQREQPLRRMYPNFTTDYMQQSDTLIIFTHYYYLLMQKDVITKETGRSLFATVHGVRYIEWYLAKLIRSFRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHI1</accession>
    <name>A0A183HHI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intraflagellar transport protein 172 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6942</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006924">
        <property type="protein sequence ID" value="VDO48584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHI1"/>
    <dbReference type="STRING" id="387005.A0A183HHI1"/>
    <dbReference type="WBParaSite" id="OFLC_0000694201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000694201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000694201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO48584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000694201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17683" checksum="6EA1A12785A575AC" modified="2016-09-07" version="1">MAIEQKNFPSAESCLLRANRPEIILRYYKESGMWQDAIRIARDYMPTELQHLEEEFDEVQLKSGAKGVLSFIAQARDWESQGEYVRAIQCYLKVKDSEKTDVDLIVDALKRAADLATKFLSDDETSSILDEITETFIHLKRYDYCTLLYNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIR6</accession>
    <name>A0A183HIR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7381</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007680">
        <property type="protein sequence ID" value="VDO50731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIR6"/>
    <dbReference type="STRING" id="387005.A0A183HIR6"/>
    <dbReference type="WBParaSite" id="OFLC_0000737701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000737701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000737701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO50731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000737701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19946" checksum="04E6E3B528533EAF" modified="2016-09-07" version="1">MFDSSNKRQNSSSVSSGVVLADFDEHSQKGASTPCAPTNWKQGKCIGSGAFGKVYVCVDVDTGKEVALKRFNICRSDKHLKNHIIQLENEINLLSTIQHDRIVQYLGAQQINDSVCIFIEYMTGGSVKDYIATYGSLSSAVAGKYTYQVLQGLEYLHRNEIIHRDIKPANILRDSNGNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT8</accession>
    <name>A0A183HJT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008288">
        <property type="protein sequence ID" value="VDO52401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT8"/>
    <dbReference type="STRING" id="387005.A0A183HJT8"/>
    <dbReference type="WBParaSite" id="OFLC_0000774901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000774901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000774901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF15">
        <property type="entry name" value="CC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000774901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="24912" checksum="3939FC3704082ECC" modified="2016-09-07" version="1">MNCELAQVCGPELDACPKGTACLVSSVPTVNICCKFASFPTAASKFSRSNLITPLCSNGRTPFYDPGSRTPRQCLTSRRGQCPSKFTCQVAKSGGLYYCCPVSQYECINGRKAYVAPGSSIPQKCSLNFNSCPPGYSCHPSADSSATYCCLDLASEAKCPNAAQPYLYANRPLACPAGSNRCPTGYDCIRSTVYSVHLCCSVSLSPIPMCTDGIAYIEPGFFNLLYYYYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJX8</accession>
    <name>A0A183HJX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7791</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008359">
        <property type="protein sequence ID" value="VDO52511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJX8"/>
    <dbReference type="STRING" id="387005.A0A183HJX8"/>
    <dbReference type="WBParaSite" id="OFLC_0000778901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000778901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000778901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000778901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18869" checksum="DEB8B30C000C8A4E" modified="2016-09-07" version="1">MGKCLLPTGEDRIVSALEGIDSSRNSVNLEENSLDSILSKQREIDDKTIQKLTETTEETSTTLTRGAAWTSAPSLKGYKPDLDVKEMKSSAIQSSPELGKLHRRSTLSTSALRHRFSRRPSRKPLGKWIKSMTLRRRKTPFSRSRYGSRHKKTKNKSPTQKDHDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKF9</accession>
    <name>A0A183HKF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008681">
        <property type="protein sequence ID" value="VDO53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKF9"/>
    <dbReference type="STRING" id="387005.A0A183HKF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000797001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000797001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000797001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000797001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12317" checksum="4CF2436A4506281B" modified="2016-09-07" version="1">MKLKRDEVRTISLERNTSVEESLIDGKQNTKTQRRKFKAIIRQLKTDKGALAKYDSVQDAIRQFATTASFYGSRNDVLCALNDSKNVLIQALQAKFEHIVLKSLSCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKJ2</accession>
    <name>A0A183HKJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 192 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008738">
        <property type="protein sequence ID" value="VDO53602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKJ2"/>
    <dbReference type="STRING" id="387005.A0A183HKJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000800301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000800301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000800301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000800301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11056" checksum="B5BBFC8F4E356583" modified="2016-09-07" version="1">TSEENFGVPGFSRIERLGPEATEEIQQTEIDDTTSTIQSSLNTEFEVKTGIPDDLIKHSQEHHDGEHISTERPQTTWNSFEESGEMKDISMVDDSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL17</accession>
    <name>A0A183HL17_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8178</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009040">
        <property type="protein sequence ID" value="VDO54397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL17"/>
    <dbReference type="STRING" id="387005.A0A183HL17"/>
    <dbReference type="WBParaSite" id="OFLC_0000817801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000817801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000817801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="4">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO54397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000817801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11496" checksum="EEECA831396031BA" modified="2016-09-07" version="1">MRFAPTFKLKCDDHLPRDVIQECNSTERLFPRWLTYLAAGFNLIIFGLGSKRILLQNFCEKKLRDYTYVVVDGFQPTVNSRIIFQHLKCEFNNIIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL48</accession>
    <name>A0A183HL48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8212</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009111">
        <property type="protein sequence ID" value="VDO54584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL48"/>
    <dbReference type="STRING" id="387005.A0A183HL48"/>
    <dbReference type="WBParaSite" id="OFLC_0000820901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552564" evidence="5">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO54584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23699" checksum="323CBF02B44DF3A3" modified="2016-09-07" version="1">MMYFKLHLLLFLLTIIDFSCAVEKEGSFHYNFDSPNFLPLQRRYKREVDEDSDDVEEGAFRLPKDVEVLEDSIDHQYYTMETKFNRSDLMKDYYIDVPAMLDKPGTVGNKSHPSLSNSYRRAVAAKIQFDFPFYGYRMRNLSIATGGFAYIGDQWHSWLAATQYIAPLMANFDTHGENATIMYADDGEKFVIEWRNLQFREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLB2</accession>
    <name>A0A183HLB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8271</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009214">
        <property type="protein sequence ID" value="VDO54884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLB2"/>
    <dbReference type="STRING" id="387005.A0A183HLB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000827301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000827301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000827301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="98"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO54884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000827301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29116" checksum="59A68FE8DF652281" modified="2016-09-07" version="1">MNYFLVGSAFTFSCRPPYSLIGKSSYDDRTIRCNVDGNWDLGDLRCEGPVCVDPGFPDDGQVKLESVEEGAQAKFTCNRAGYKPFPSDTINCTLGTACVLAEDVGISSGFIPDGAFADNSDSTTWGYEPHKSRLSSTGWCGSKDAFIFLSVDLQRVYTLTTLRMAGVAGSGHLRGHVTKMQLFYKVQYSQNYDTYPVEFETPSGNHNAMHQFELNPPLRARYILLGVTEYEQNPCIRFDMQGCLAPLSVAHEIPSHLQVVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMT6</accession>
    <name>A0A183HMT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">I-set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8798</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010248">
        <property type="protein sequence ID" value="VDO57457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMT6"/>
    <dbReference type="STRING" id="387005.A0A183HMT6"/>
    <dbReference type="WBParaSite" id="OFLC_0000879701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000879701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000879701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="2">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO57457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000879701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23090" checksum="D6CBD1F978E92888" modified="2016-09-07" version="1">LNIILEAITDTPPKFIQQIPNLTLRPGTEAVIDVEVEASPPAKFTWYVNGVQFRDTVGQIEVYYPMANRCIARFPIPQKGEYKVIAENRAGKEQSIGYIDVKKEIMYHQTQLPPLPSDHVYHHASYKESEHREMPVQQGRGRASSLSRMVDSYEESSFYERSTSLPRHFDRPYEIKKTTEMIRKRKDGLLVSSSLESWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP79</accession>
    <name>A0A183HP79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9291</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011246">
        <property type="protein sequence ID" value="VDO59569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP79"/>
    <dbReference type="STRING" id="387005.A0A183HP79"/>
    <dbReference type="WBParaSite" id="OFLC_0000929001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000929001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000929001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000929001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8535" checksum="64AC46D55BAEA7D8" modified="2016-09-07" version="1">MHSGVNVKDHRDSLTLDVVCDNLISSPTLQTMRKLIGMVIASQGKSHHSRIDVGYDNFLKSMREEHWNTRNTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPT7</accession>
    <name>A0A183HPT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9498</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011700">
        <property type="protein sequence ID" value="VDO61074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPT7"/>
    <dbReference type="STRING" id="387005.A0A183HPT7"/>
    <dbReference type="WBParaSite" id="OFLC_0000949801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000949801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000949801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000962">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000949801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28021" checksum="95BABD13B7CDAFCB" modified="2016-09-07" version="1">MECRVSPINDSKLTVSWLKDGKSLTEASRFKPTCEFGFVTLDILYALPEDSGDYECVVVNDKGEASTRTHVTVLSKPSVEFAPQAPGANIENLENHLRQHTRVALALTKNDAYNEATKRPPEFKTELTNIGVEESDYCRFETQVAPINDPYMKIEWFKDGKPVLIGHRFRSVLDFGFACLDVLYALPDDTGEYTCIASNPYGKATTSAKLACSGSKHIITESQLPQGVLVSDVKNLGDQPYWFVCFFFLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQI8</accession>
    <name>A0A183HQI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9750</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012301">
        <property type="protein sequence ID" value="VDO62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQI8"/>
    <dbReference type="STRING" id="387005.A0A183HQI8"/>
    <dbReference type="WBParaSite" id="OFLC_0000974901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000974901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000974901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000974901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12056" checksum="4E30DD1262A6E1A3" modified="2016-09-07" version="1">MQLTNPVWIHHSGGAIYSVDIHPDGTKIATCGQGGEGGSGLVIIWNVKPVINEKASQEASCNRLLSRILHQNCVNCVRWSPDGAYLGCAGDQQSLTLWEFGGRVFSAGTIDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQK1</accession>
    <name>A0A183HQK1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9764</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012321">
        <property type="protein sequence ID" value="VDO63067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQK1"/>
    <dbReference type="STRING" id="387005.A0A183HQK1"/>
    <dbReference type="WBParaSite" id="OFLC_0000976201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000976201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000976201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO63067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000976201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18688" checksum="C8EC50C0A736E5AD" modified="2016-09-07" version="1">GYATVIARVHDECISTQNWEKLSSISDITYSLELKNMTPLCTTVSYKTNGKRIVKVVETIDVDDSFRLIFKQYKAQDSNTFAEKSDNLLMPESSFDIGLRLKKSELEAKQRVSLPYEAAQKEEELVKLRVRENRKIRAGGRIIYTPDEADDFDESDPDDDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQT6</accession>
    <name>A0A183HQT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9849</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012535">
        <property type="protein sequence ID" value="VDO63888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQT6"/>
    <dbReference type="STRING" id="387005.A0A183HQT6"/>
    <dbReference type="WBParaSite" id="OFLC_0000984701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000984701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000984701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000984701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18922" checksum="36E6D3AD3EA50399" modified="2016-09-07" version="1">SIAELCYFDFVAYQLIYIYIAGKSVVAEVNGTKLSERISVWKLLGALTSLYPSTPEHADICTHIDYWLLLIDDVLSNRSNEDNLCRQMSAALSRHDYLVPNIAATLADVLAYSVITKQSYYANNVELCPDICKYLFGRLPRTDYLSLMSFKLGTVPLRRTYLYLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRB5</accession>
    <name>A0A183HRB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bac_surface_Ag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10022</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012920">
        <property type="protein sequence ID" value="VDO65225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRB5"/>
    <dbReference type="STRING" id="387005.A0A183HRB5"/>
    <dbReference type="WBParaSite" id="OFLC_0001002601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001002601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001002601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="3">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO65225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001002601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21180" checksum="68393EE9B5E62F64" modified="2016-09-07" version="1">MTSRGETDYSLNAGKESFGGRGESVNACYSRTFEGNQTFDVSMTKPFLGWQKYANVGFSLYRSLGNLPWNLSNMQELGLILQYNGQLWNRRLHHNMKFNMIWRQFYPMEKAAFSIREHAGHTMKCSLLNSLAYDTRDRPLLATKGALLKFVQEYAGFLGDAAFVKHQIDVQVSYIIHFFIIILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSM3</accession>
    <name>A0A183HSM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exosporium leader peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10486</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014016">
        <property type="protein sequence ID" value="VDO68853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSM3"/>
    <dbReference type="WBParaSite" id="OFLC_0001048401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001048401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001048401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001048401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="5906" checksum="345F0B9120A4EB13" modified="2016-09-07" version="1">MRQKKSPSKSSTPQVEGYSLDGTPFASPVGTGSTGTPLPETYYNIDLVLLFYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSS4</accession>
    <name>A0A183HSS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10535</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014138">
        <property type="protein sequence ID" value="VDO69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSS4"/>
    <dbReference type="WBParaSite" id="OFLC_0001053501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001053501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001053501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001053501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7744" checksum="DE79005AC8BF4D17" modified="2016-09-07" version="1">MGELYIGYDDRKLEKEIEALYKDKEKAQPVERLVSKEKIEKEKKRKDEEESASSSEEDGKFDQDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTI4</accession>
    <name>A0A183HTI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Short coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS10790</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014810">
        <property type="protein sequence ID" value="VDO71360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTI4"/>
    <dbReference type="STRING" id="387005.A0A183HTI4"/>
    <dbReference type="WBParaSite" id="OFLC_0001079601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001079601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001079601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO71360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001079601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12471" checksum="317ED6210917105D" modified="2016-09-07" version="1">MSSDTTIMDEADNFPLADDESQGSSIDTGGRTPRPAHPLPRGESEDQEEKARLISQVLELQNTLDDLSQRVDSVKEESLKLRSENQVLGQYIQNLMTSSPVFQPAQPKASQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTR6</accession>
    <name>A0A183HTR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10878</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015017">
        <property type="protein sequence ID" value="VDO72073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTR6"/>
    <dbReference type="STRING" id="387005.A0A183HTR6"/>
    <dbReference type="WBParaSite" id="OFLC_0001087801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001087801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001087801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001087801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20834" checksum="B1484664F2115631" modified="2016-09-07" version="1">MVREYSKNGWLQALSENLTYVRTLSPEQLGFGVRCKFTPPTTQKMETIKICLRKMQHHYSPLKKLENLLRVIFLAIGKQQNCDNPNGDIENYDPVNIESSKIKTLPPADELVRWLVYLLARTSTVGCEVEAWYMWELLPKQLLTTGDSSYYLITLFSAIDVLKNTESIRKLGQVDDSSVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU88</accession>
    <name>A0A183HU88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LRRNT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS11049</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015452">
        <property type="protein sequence ID" value="VDO73428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU88"/>
    <dbReference type="STRING" id="387005.A0A183HU88"/>
    <dbReference type="WBParaSite" id="OFLC_0001105001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001105001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001105001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF10">
        <property type="entry name" value="LD45603P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552646" evidence="12">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO73428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001105001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15746" checksum="953541E9F47CB12A" modified="2016-09-07" version="1">MIIISSLIILLLLFISVVWGLCPQNCTCDNDYQLAVNCNNVKLRYLPSLLNPGTQFLQLSKCQIEQLDPDIMELYPDMIHLDLSSNSISALGNNVFRYQSKMRFLNLSNNNFSKIFLNSFQGLHRLQVNFRKIIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU90</accession>
    <name>A0A183HU90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11051</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015459">
        <property type="protein sequence ID" value="VDO73433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU90"/>
    <dbReference type="STRING" id="387005.A0A183HU90"/>
    <dbReference type="WBParaSite" id="OFLC_0001105201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001105201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001105201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001105201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="13161" checksum="9DEB881F8419B0FA" modified="2016-09-07" version="1">RQNFRLPWRSLKDDYDRICYFKTYFYKTNAFKKLPRQLRQIYRSVLYLINWCPLKIENWDCKDKTLEMLSKTGSAMVDFKFVIELFKKAIDNRDHNNKFQIPDWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUG4</accession>
    <name>A0A183HUG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11124</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015655">
        <property type="protein sequence ID" value="VDO74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUG4"/>
    <dbReference type="STRING" id="387005.A0A183HUG4"/>
    <dbReference type="WBParaSite" id="OFLC_0001112601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001112601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001112601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001112601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16521" checksum="AB3EEE46493B0BA1" modified="2016-09-07" version="1">MNELRGKYDSSTYHVNNAQTVLVSLDGNLLRVSRPERAVLKHAFHTDPTLAEAEPAISSQSIYNLTGAVVTLRPKRLARRRWWSRKYPIHIRLASRDSEISTFPLLRRSFSMNEPIKLAKSSSSSDEGCDTTAHNLVRGRKKKMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUZ8</accession>
    <name>A0A183HUZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11305</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016184">
        <property type="protein sequence ID" value="VDO75505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUZ8"/>
    <dbReference type="STRING" id="387005.A0A183HUZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001131001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001131001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001131001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001131001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8670" checksum="8F1ED2E4D74A7485" modified="2016-09-07" version="1">MNGFANELNPFSDDENEAKEILEVDIRTEIIRVRFPSLSLHISIADLLCLAEGELLNGTIIDFYLNHIRCHLIQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVH7</accession>
    <name>A0A183HVH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11483</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016625">
        <property type="protein sequence ID" value="VDO76796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVH7"/>
    <dbReference type="STRING" id="387005.A0A183HVH7"/>
    <dbReference type="WBParaSite" id="OFLC_0001148901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001148901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001148901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001148901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8203" checksum="2D5F1BAB73B96ED3" modified="2016-09-07" version="1">MSEMIPSIEIGPNNISSFLSETVNFGGITVDSQAITAATISAKGIADHHVQYKVELHKVNSNGTLQPINGPIVVGDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVN7</accession>
    <name>A0A183HVN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11548</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016791">
        <property type="protein sequence ID" value="VDO77276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVN7"/>
    <dbReference type="STRING" id="387005.A0A183HVN7"/>
    <dbReference type="WBParaSite" id="OFLC_0001154901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001154901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001154901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001154901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11067" checksum="396C1D97C5E8FA02" modified="2016-09-07" version="1">EFLDRIFVASCSTEIGIVDQHIFRVLLDNIIISNTFLSDCLSASYSTNTSRSVSTSTDLLQKQHSSASRQQSGSLSAQKYNLELKSDFCAYVIRQVGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWL1</accession>
    <name>A0A183HWL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DBR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11873</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017720">
        <property type="protein sequence ID" value="VDO80011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWL1"/>
    <dbReference type="STRING" id="387005.A0A183HWL1"/>
    <dbReference type="WBParaSite" id="OFLC_0001187301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001187301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001187301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001187301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11024" checksum="E0F7454B533598C7" modified="2016-09-07" version="1">MPSQHTQNERWDFRPTEEELAKVEEIYGGDFIIPMNFKMTACPHRANETNIGSQELYYRNPQSTEFCAKLGIRDLNEMLCSLSMDGLGIPYYVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWS0</accession>
    <name>A0A183HWS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein transport protein Sec61 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS11937</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017890">
        <property type="protein sequence ID" value="VDO80554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWS0"/>
    <dbReference type="STRING" id="387005.A0A183HWS0"/>
    <dbReference type="WBParaSite" id="OFLC_0001193201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO80554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12116" checksum="EB35BADCA377086A" modified="2016-09-07" version="1">SGRSARGGVSSGGLWRFYTEDATGLKIGPVPVLVMSLVFIASVFILHIWGNKLNPKNKCKILNISVTCFGIVDCILLFGDCLVLLICDSNLCINMLLTPVNCDDLFGCAKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWY7</accession>
    <name>A0A183HWY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018046">
        <property type="protein sequence ID" value="VDO81039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWY7"/>
    <dbReference type="STRING" id="387005.A0A183HWY7"/>
    <dbReference type="WBParaSite" id="OFLC_0001199901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001199901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001199901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001199901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8752" checksum="F9CCD5B2A36C353A" modified="2016-09-07" version="1">MDRYDRSIFQRNCNMTPREMFENFKPDGVKRIQCQFKNADGTPVHPPDPQTTINTTMIPVTDLQPINVERSNIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXA5</accession>
    <name>A0A183HXA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2405 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018406">
        <property type="protein sequence ID" value="VDO82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXA5"/>
    <dbReference type="STRING" id="387005.A0A183HXA5"/>
    <dbReference type="WBParaSite" id="OFLC_0001211701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001211701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001211701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001211701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15567" checksum="945B10BE32799B98" modified="2016-09-07" version="1">MDLGRNEFKNLKNRTNKLWIWSADAVMFIFPYDYNFAAAYDEIINAWKWIKLVHEWKRKPFTIESPLPSDLKFSIKNASLQINDDPFEVQLQNNYELMVDEVYECERRRQMLDQKLEQLQKTRPFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXJ9</accession>
    <name>A0A183HXJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12214</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018670">
        <property type="protein sequence ID" value="VDO82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001221201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001221201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001221201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001221201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15603" checksum="CD7C4EBDE7C9C25E" modified="2016-09-07" version="1">MQFTPYFLLLSAISGATRYIWINLIDVEIGNLLIDEQQIDGLRSAVMQMQSLINIRHLPENDRLNAKSLTSCTTHWHPSTDKCFMETVHDWQKSNLIDITKDINLKFYNVNFLLFLQVIYLQVISTVIYNFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY99</accession>
    <name>A0A183HY99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JAKMIP_CC3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039848">
        <property type="protein sequence ID" value="VDP11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY99"/>
    <dbReference type="STRING" id="387005.A0A183HY99"/>
    <dbReference type="WBParaSite" id="OFLC_0001246201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001246201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001246201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="597"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001246201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="727" mass="86247" checksum="A3A3E7DC458E68A6" modified="2016-09-07" version="1">MSKEDYERDRLRWQQKLDDTSKRLADAEIVNSEMNQIKAELNKKIVEMERIQRPLIEQNRRLTERNRILQNEMKNCEQRLCHSQDDFLTLKDEYERLVKDNQNLKERRAFPEKLEELDRYRNQVLEYSKCITALRQAGLEKDRRYDLLVQKFKRLRKCISSRKNGETEEDRQSSFGGSDCSAESSISLNTITEDLNEALDKDIENGYQQIVREGEQLRRTLSVLKTGEYGLEDDQLLRHQLICAQTTIAQQQVVIEQQQLQSENTMELLDSIARLQEQVMEQRSKMESMEAELIESKEMNELLEFQILENKENMEHEFEERQMLKESASKDTMTDLWISEEDECTFLSQMSPLPDFGTICNRKCELINLRRSALLSTKQRELIQQVLTYIEHLEDQLLHLKIDTEQKICQFLLKEAENATKIQDLEERIEQSCSKQKKDDLQMEVEVLRKRELELDSEKQMLNDEVNRMSKEMGKLRYLLQQKDEQLALQGDKNSEQESRIAKLKTQIQCYTDENNELHNQLRKCTESLQHSEEFLVKKKEEMKLLEKENARLQVQHRTALDEIQRLRDDIRPEVKTDLERRFEEYRYRLSCALKTVHEYEDEISKLRSHMAKLESKSQERNDNTVIELEQIREYSEQLEEQFTAQVGIIEALKRRIVQQKALTDFLWSMTESDELSFAKAEDKLTRFKSSQQDEPTCQLTDAIQKLLRLVSTNCAYSHKTLSSNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYC3</accession>
    <name>A0A183HYC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12485</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039853">
        <property type="protein sequence ID" value="VDP11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYC3"/>
    <dbReference type="WBParaSite" id="OFLC_0001248601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001248601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001248601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001248601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11958" checksum="4F59197C5FF5C34A" modified="2016-09-07" version="1">MLLLRGVERSKKSEVIVVGNCEGGREQISIDKEDIASSDLGVSICSLRMIYSRGTAGRKCAVCGARNSVDGGALSKCKQCSMTVYCGEEHRIRELFLNEQFKNSDDYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYC6</accession>
    <name>A0A183HYC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039853">
        <property type="protein sequence ID" value="VDP11430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYC6"/>
    <dbReference type="WBParaSite" id="OFLC_0001248901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001248901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001248901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000039">
        <property type="entry name" value="Neuronal SYmmetry"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001248901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31156" checksum="C8AD85E1FC2ABDCC" modified="2016-09-07" version="1">MGSTAVQKGLLVISILLIVVGLGLTFAGVFSPAWQVVDIREFRAEHQHGLWWDCTRAEKHVVAVGDFYAEEPLHCMYKFDRSAELVIEMTLNNIDEDGAAGESEHHRFWAWHKAILFFILFSQFLAFISLCTGVCIPCFRPTAFIFTLSLFLALLCSLIADGVFFLAANRVDNRFVQGMVGSYEQRIGYAFYVHLLGTLCWLFAFLFALLTTYKFFTERYSSRRSDQISIFSSGMHFRSDVEPPLLEKYNVAPTRPSPPVKYVREHTYRVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYI2</accession>
    <name>A0A183HYI2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spectrin beta chain, non-erythrocytic 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-III spectrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS12544</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039864">
        <property type="protein sequence ID" value="VDP11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYI2"/>
    <dbReference type="WBParaSite" id="OFLC_0001254501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001254501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001254501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000049">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="164"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001254501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1572" mass="184256" checksum="765880F1398B3217" modified="2016-09-07" version="1">MTTDIAVRGHDYNGRIEDYEEYDENSSARLFERSRIKALADERENVQKKTFTKWVNSHLLPINCKIHDLYMDMRDGKMLIRLLEVLSGERLPKPTRGRMRIHCLENVDKGLQFLRDQHVHLENLGSHDVVDGNPRLTLGLIWTIILRFQIQDITFEDADNQETRSAKEALLLWCQMKTAGYPNVNVRNFSTSWRDGLAFNALIHKHRPDLIEYEKLQKSNALYNLSNAFEIAEQQLGLIKFLDPEDVNIDVPDEKSIITYVVTYYHYFNKMKQETIQGKRIGKVVNELVENEKLINNYERLSSDLLEWIRQTIESLNDRHFVNSLSGVQKQLAEFNNYRTQEKPPKFNEKGELEVLLFTIRSRMRANNQRPYLPRDGKLIADINRAWENLERAEHERELALKEEIIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGTDLASVEAATKKHEAIETDIYAYEERVQAVVAVAGELEAENYHDIDRINDRKENVLRLWNYLLELLLARRVRLELSMAVQRIFHEMVYVLDWCDEIKARLLSEDLGQHLMDVEDLLQKHALLESDINIVGNRVKNVNSQAEKFTLPNGPDGSGYKPVEPSLVEERMQILLDRYAELKELAVERKRRLEDNKRLCQFWWDVDELEHNLRDMEQVLTSPDTGRDMVSVSLLLAKHKNAEQSLDIVGKRLDDLEIEGQQLQEESIPGAEVINSRLTTIRDYFNKLKELAAERHVRLSGGVNYYQFFNDADDVDAYLVDTLRLVGSEDVGKDEGTVQLLIKKHDDVSDDLLKFEENIKQLHIQAESLPPEAREHPDVRKRLDMTERRKTELEELARLRKQRLLDALSLYKLFSDADIIEAWIDEKGKLLTTLIPTDDLEEVEIMKHRFETLEADMNNQAAKVATVNELARQLLHVDHPNSDEILQRQNKLNARWAQLRDMVDQKRSELDQAHRLETFRIDCQETVSWIEDKTRVLEDADELTNDLTGVMKLQRRLSMMERDLGAIQAKLDSLQKEASEIEKEKPADAVQIREDIKRMQLAWNLLNRRVREHEAKLDEAGDLQRFLRDLDHFQAWLTATQRQVASEDEPQSLADAEQLLNQHAAIREEIDGYAEDYVKMRAMGDRVTQDQTDPQYMFLRQRLAGLEEGWEELQRMWDNRQHLLSQGLNLQASMFLRDAKQAEVMLSQQENYLSKDETPTSLEQAENMLKRHQDFLTTMDANDEKIKAVVSFGDQLCGDGHYSADKIHKKARNIEERREANREKAGHLFNKLKDSLALQQFLSDCEELREWIEEKMIRAQDETYRDAKTITSKFMRHQAFQSELQSNRERLVQLRHAAVRLAEEKPEFLGTIDPQIADLSVQWEQLEKTTEEKGQKLFDANRQQLYVQSISDMKDWAEQLQQQMTIEDTGQDLTTVNVAMQKQQMIESEMVKRAAQIDSLQQMEPQLEEMHPEEVEAIKAHRLAVQEQLQRLQAPLDDRRRQLERKKRAYQFLRDVEDEKLWCAERLPLTQAQELGESLFDCNRLQKKMQSLKHEIENHEPWIEKICQNGREMIDEGHENSSEFQQKIDELMKICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZY4</accession>
    <name>A0A183HZY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13046</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040023">
        <property type="protein sequence ID" value="VDP12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZY4"/>
    <dbReference type="STRING" id="387005.A0A183HZY4"/>
    <dbReference type="WBParaSite" id="OFLC_0001304701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001304701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001304701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048370">
        <property type="entry name" value="ZSWIM4-8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21055">
        <property type="entry name" value="ZSWIM4-8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZSWIM4-8 C-terminal" evidence="5">
        <location>
            <begin position="718"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001304701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="928" mass="102739" checksum="A6A7E49B0790C201" modified="2016-09-07" version="1">RRRTTSGIVTKTGVQRRPCDEELAIKVALEALGMKLVVSEADYPMLCESTRLQRGDLALTMLLRYKDSNDKLALVLDKLLDPTMHRMYRDHHSNAAFFLEQDPLYKKYFNGQRPHFSLKDEFHHTEFSETSNARLTSAETNIMAVENMHEKRMIHVVPNNGKDETEQLISSFMRLSHDSPDDSSSVTSASRRRSSDESNDSPYDESSSSGVSRCFPRDTLHESYSASVGTLDSSSPAHRLSNILTADSSEFPSSPASHPVELNNVFYRHNRRKPIPSLPNQASEGQAHCMMELAKRLLLEAGGSQNTVIFNASQGSQNNPQRSGPHRQLHICSFLIGLYALGLNNLLSASWQTRTYSTNVSWIHGQAIEIGCAAIKIVERVWEAHLTPTEVAALADKASQSRDPCMVEAAAKLALSVLPKAYALTAAESQKALHQCKEQSSEMLEKACRAVEQAAEKDGVYPEVLFKVARHWFDLFLDSESGTNPQTSFQNTIPPHSTGIPQLHNDLQSQAHESIYSSTNPQALQLPIQCRPFAAASYHFMPPHHHIHQAGPHRPPLYVSPISCAQPQVGIHYSQRGPLPVGAMSMMPRQQPNAIYPPPIVGATPSRALHISHSAPNLSPMQAVQISRRNQPLTVLQQSLCLGTTRCQFPTVGEQCIQPIPINDALRHHLPPPTSLVLCQSASQPITYFGQAAPQPSINVPLPSPSASVVGDPRMAKLVHAHRVGMIAMETMGNRNLDDNRSYAKFSQNPAYAEDVRWLFTVATRLGGVFTQSFCEVAARSVASPFVLFSLAVESAKVGHYVFHWQMPSLSYHSQAVIHPIRPQLTAGAPNVRAVLLQNGFAPPTADLMQHCVEMFYAASSSKLSHPRFVPSDVEEVVQLVKTAKEAFHWIPGPGKLMFDDFMRHVRKQKACKKDVAQRINACVQNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I041</accession>
    <name>A0A183I041_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13103</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040046">
        <property type="protein sequence ID" value="VDP12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I041"/>
    <dbReference type="STRING" id="387005.A0A183I041"/>
    <dbReference type="WBParaSite" id="OFLC_0001310401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001310401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001310401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552708" evidence="2">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001310401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16735" checksum="ACA9C80DDB70E04E" modified="2016-09-07" version="1">MVYALATFLGLCCLSLCFIAAICNGSSVTVFSLQIVEASPNLFTDWKKMAISWRTYSVLFFLLVGGIERVVGESLTFYALFRPELSLSQRNGLFLTSAFWLGIVTVRALFVLMTKFINIGRLSNLVLFSAAVAGYVAASAGSLFAVLCTVFILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0F4</accession>
    <name>A0A183I0F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FBA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040092">
        <property type="protein sequence ID" value="VDP13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0F4"/>
    <dbReference type="STRING" id="387005.A0A183I0F4"/>
    <dbReference type="WBParaSite" id="OFLC_0001321701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001321701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001321701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37962">
        <property type="entry name" value="MALE STERILE (3) 76CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37962:SF2">
        <property type="entry name" value="MALE STERILE (3) 76CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001321701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22873" checksum="983AB8E6B23B0674" modified="2016-09-07" version="1">MKSFLDLCSSDFLKDHLQIYMILIVFERSVLLVYERECNAIFLLDTHTHMKKKNIKTGGLIAMCSVNDLDFLIKWMCKNIFPETTYKLNHDQSFEVSVIAFKGQLQEDDHPLFVPRMIKTPHMQQFNTLMLFNTTIEGDMLLQIISYLMVWWLENICGSPGFTFSILKKVPESYILEEEKSKALGEVKIHLPLDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0F8</accession>
    <name>A0A183I0F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13220</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040094">
        <property type="protein sequence ID" value="VDP13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0F8"/>
    <dbReference type="STRING" id="387005.A0A183I0F8"/>
    <dbReference type="WBParaSite" id="OFLC_0001322101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001322101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001322101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001322101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63403" checksum="360CA57FA5443D59" modified="2016-09-07" version="1">MVARLPTIEITLYFLVWISHSLAAFYIAWNVTFNFRDKLVLKASEYINGYKKDIADFEWTYYSRSLGRILIINILHTGNRTCLKNTLLFKICPVFLPKQLSQYSLLIFWIFAEIFFTSKYCKKEMNFSFTCVITVFMLAVVISILTNYWRNELVSWLIVIIFIVKINSIAYFSRTEDVYFREFNYYLYSAVKILNFCIYLSRTKGVSFSSSLFVRYTQYIFYPPYSITLIVLFNDFDAEMTEIESGSSKCINYRALLLRLARIIAWFVLFEVILHVIHVHALFVTNPALFNTLHEYECNCYIIVASVAYVNGKLFYMKYLLLFGIPSWFASVDGMKPPAGPACISRISNYSQMWRNFDRGLYEFLKRQVYIPVAGDPSSKYFSLRRLAALLTVFLFVFAWHGTSSNYFYWILLNILEICMEWIGIAISKTAFYSKIRNFLGPRGERRLIATSMIATAASGVFGVFFFLSRNEIGIIIFKRLFMSIIGRLLRLIISLPDRPFTYYAIAVHILILGYCFNNVCLELEKYFAIKGASEDKVKRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0U9</accession>
    <name>A0A183I0U9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13361</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040164">
        <property type="protein sequence ID" value="VDP13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0U9"/>
    <dbReference type="STRING" id="387005.A0A183I0U9"/>
    <dbReference type="WBParaSite" id="OFLC_0001336201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001336201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001336201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="3">
        <location>
            <begin position="72"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001336201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57194" checksum="0C0998CB22E54794" modified="2016-09-07" version="1">MDVEIIRNFFNKNLNVTLQEEWLTEVVTYLNSLGFNSDSLLSAVYEQWLYTDLKISTKPLLSLSVDNCSTRKVLGSNTVIQINSIIDIGASLCSQYRNLTKKFEDNSGFQLKLEENETNSDSSQNMKRMLSMEVTDGQLSMKAIEYSPLNALSLLTCPGCKILLKNNVCFRRGILLLTEVNCIVLGGDDDLLMKTGRPVEVIMMRLNIGTSLQRQNFMSLTKIGKEMKHNDIPNANNVFFSQSNMKPVMEVKPLSGEISLSETPRRKVITASGTPRTEQSVNSIWNRINVSLNESPSCSDSRTPVASISKRPMNLSSHNAHAKHIKMEVVDDDVIVLGMSASVKEITGKDSSGKTNLPATPKLIDDPVIAAYKRLGIESISAALRTMRFAVGSKRKILAAIMETKPLEPLHVNNDKLWALTVALSDESYECLKCVASHKFLVELIGWTPEEAIDARASKDRARRKEGSLRTKSAAQAMRRLDLIWEVEFFPSGGLTPIIHKIDTYAQKFGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2X4</accession>
    <name>A0A183I2X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14086</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040587">
        <property type="protein sequence ID" value="VDP15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2X4"/>
    <dbReference type="WBParaSite" id="OFLC_0001409401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001409401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001409401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001409401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="18753" checksum="741C5CD07A33DBB0" modified="2016-09-07" version="1">MEIGGSMERSDHMAKLATEEIDIDRSSRSFIGEPDEDNDLAVESYAVKRSSTRWSSHRNTVVRTGSESRSYHSPPGRMTSGMKRRAEGNYTTEKRPYLNCHYMIGSNQIAFSDDSGMSHVHFCCPFRLASRPLTTKAATATAAAAAAAAAAAADAAAADAATAARTEGGGGGESIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3L2</accession>
    <name>A0A183I3L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14324</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040767">
        <property type="protein sequence ID" value="VDP16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3L2"/>
    <dbReference type="WBParaSite" id="OFLC_0001433201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001433201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001433201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552755" evidence="2">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001433201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14082" checksum="0A80DBB974DB33A4" modified="2016-09-07" version="1">MAKRFLLFVYIIFCLPPPHDDDRRGGGGGGNVEDEDMAEEKKADEMKKDEEKKKVDEEMDNDAEMEKKEEMDEDADMKDKKEMDENADMKDKKEADEYEDMKDKKEADENEDMKDKKEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I459</accession>
    <name>A0A183I459_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14521</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040922">
        <property type="protein sequence ID" value="VDP17438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I459"/>
    <dbReference type="STRING" id="387005.A0A183I459"/>
    <dbReference type="WBParaSite" id="OFLC_0001452901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001452901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001452901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001452901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14698" checksum="6F9CB866A1A1509C" modified="2016-09-07" version="1">MIEQINTLTGKKAFTSIAVCSSNGMLITGSVDPIVRLWDPRSHEGTLVKQSFIGHCGWISSVFWNKMRENLFISASFDKTVKIWDIRSNKTPLYDLVGHSDRILCCDWSVNEIIVSGGVDCTIKTYRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I499</accession>
    <name>A0A183I499_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14561</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040960">
        <property type="protein sequence ID" value="VDP17627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I499"/>
    <dbReference type="STRING" id="387005.A0A183I499"/>
    <dbReference type="WBParaSite" id="OFLC_0001456901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001456901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001456901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP17627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001456901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37856" checksum="75B866D1BF8ADA59" modified="2016-09-07" version="1">NLIILKAVERRDALVKILYAAAFAWLVSKINEVLGEQMKNNKSKSTERFIGVLDIYGFETLEVNSFEQFCINYANEKLQQQFCQHVFKLEQSEYEQEEIDWIRIDFYDNQPCIDLIEGKPGIIDYLDEQCKIGHGTDRDWLEKLRICQSLKKTQHFQLSKIKNPTFIIKHFAADVIYNVDGFLAKNKDTVSEQLMTVMKESKFRDSLRELMAVLSTTRPHYVRCIKPNDEKLPFTFRPKRAIQQLRACGILETVRISAAGYPSRWIYEDFARRYRILYPEKKLWLEEPKIFAEKACSKFLEVSFVACLYSVHSKIEQLSCGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4V9</accession>
    <name>A0A183I4V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14771</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041176">
        <property type="protein sequence ID" value="VDP18674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4V9"/>
    <dbReference type="STRING" id="387005.A0A183I4V9"/>
    <dbReference type="WBParaSite" id="OFLC_0001478201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001478201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001478201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="72"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP18674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001478201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22224" checksum="885EFD67756A6CD5" modified="2016-09-07" version="1">MDNSSDLITSLDYTSEDPDLETLKKRMKEIEEETQLIRQIQRNVEKQMNLSTSNNTSQSAASIEDKIEADSRSIYVGNVDYYSTAEELKAHFYGCGSVKRVTILTNKFTGHPKGFAYIEFADKEAVQTALALDESFFRGRQIKVCAKRTNRPGVSITGRPSHARGRRDGRVIVKYIYAGYRIKRPPRRRGIFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4X3</accession>
    <name>A0A183I4X3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS14785</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01041197">
        <property type="protein sequence ID" value="VDP18773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4X3"/>
    <dbReference type="STRING" id="387005.A0A183I4X3"/>
    <dbReference type="WBParaSite" id="OFLC_0001479601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001479601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001479601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000024">
        <property type="entry name" value="Histone deacetylase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP18773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001479601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49652" checksum="4BA14840ADB53159" modified="2016-09-07" version="1">MTSKREVCYYFHHDVPNFHYGSRHPMKPQRLAALHSLVVNYGLHKEMLVLTPPRASAIEIERFHSKDYVDFLQRVSPRTADQYENLFSQYNIGEDCPIFDGIFEFCSIYTGATLSGVARLNHGLSDIAINWSGGLHHAKKREASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYDVGQDSGRYYAVNVPMKEGMDDENYHSLFKPIVQAVIDCFNPSVIVLQCGADSLGCDRLGCFNLSFSGHGRRPLVIKHHFRECVDFVRSLGIPMLAVGGGGYTLRNVARCWTYETAILVGKKDEIPDEIPNNTEYLQFFAPEFTLRPTLAKRQENQNTKEYISALKQEVLDHLRQIRHAPSVQMQEVPPDLLDPYEVFSVQESPPDVLSTDNDPDGGTFFGTNSEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5H0</accession>
    <name>A0A183I5H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14982</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041444">
        <property type="protein sequence ID" value="VDP19874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5H0"/>
    <dbReference type="STRING" id="387005.A0A183I5H0"/>
    <dbReference type="WBParaSite" id="OFLC_0001499301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001499301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001499301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001499301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21334" checksum="D5AA0B7BB1698A12" modified="2016-09-07" version="1">MENGYNAESSSSALPSSSSYAYPYVNCCSSYDTYGTYSFTDLYGSYEMNKYYQQLPNPSNQYPHHHHQHNQTQIYYPHYRTPIASTSNYAHLFLNGTIPNNYYSTPTTTIANTATVNYNTNSSFGRGNRFVLQRPKYAWMLEREKDHQQSRHFQQPIRSTTDTVITSQTGNSYIIFDLLRFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5N2</accession>
    <name>A0A183I5N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15044</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041535">
        <property type="protein sequence ID" value="VDP20143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5N2"/>
    <dbReference type="STRING" id="387005.A0A183I5N2"/>
    <dbReference type="WBParaSite" id="OFLC_0001505501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001505501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001505501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP20143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001505501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36680" checksum="E63F7F964DA835C5" modified="2016-09-07" version="1">MKDMIEEAKGHVAKSSKVGNPRYARVNTLKWSFDEALQTLQDEGWTISNLKPQENDNWYKTIVSSMSEDQVYIDCHVSELLLFPANTDLHQHWMVTDGYLLLQDKASCLSSLVLNPKVGSCIFDICAAPGMKTTHLAALVQNEGKIWAIDKASDRIKTLRTMIEKAGAVNVSTYCGDFLRTDVMNKRFNKIRYALLDPPCSGSGIVKRMDQLIDEEERTNTSRLRSLSNLQAMLLKHAMGLPNLKKIVYSTCSIHEEENEQVIEEILNDDSLRTRFKLIKAMPKWPHRGRANYSFGYKCLRALPEIDLTNGFFVAVFKRQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6B0</accession>
    <name>A0A183I6B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15273</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041864">
        <property type="protein sequence ID" value="VDP21115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6B0"/>
    <dbReference type="WBParaSite" id="OFLC_0001528301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001528301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001528301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001528301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6709" checksum="B12A8D7D2C9617EC" modified="2016-09-07" version="1">MVIEGSCVFRHRGIMVVEGSCVFRHRGIMVVEGSCVFRHRGIMVVGEIYIRHHGATIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6K3</accession>
    <name>A0A183I6K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AP_endonuc_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15365</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042017">
        <property type="protein sequence ID" value="VDP21528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6K3"/>
    <dbReference type="STRING" id="387005.A0A183I6K3"/>
    <dbReference type="WBParaSite" id="OFLC_0001537601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001537601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001537601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP21528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001537601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26336" checksum="DC6CCCBA9E220670" modified="2016-09-07" version="1">MISIDDKEESCGDSVHPEAVLVASSVDDLKTEGDDSKKGMFKHKSTQVKSRKTKNLIKKKVKESSDNNSRVRRTRQRTKISDSTSEIKQGIKDAKKISVSLAKANFTKDNLVNPIAQKVMEAATGSRKMLGAHVSVAGGLEQGFYNALSIGCRSFAFFVRNQRSWNSPPMKDEVVQAFRETAKKLEFPMDQIVVHGSYLINGGSCDMEILNRARACMLDECKRCEQLGIIYYNIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6K6</accession>
    <name>A0A183I6K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15368</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042021">
        <property type="protein sequence ID" value="VDP21548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6K6"/>
    <dbReference type="STRING" id="387005.A0A183I6K6"/>
    <dbReference type="WBParaSite" id="OFLC_0001537901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001537901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001537901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001537901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15568" checksum="76EFE0E0094F4D66" modified="2016-09-07" version="1">MHEPFLYSNLQDCKDLLGQGKTENGIYQISLPKVGKFNVLCDMKTDGGGWTVIQKRQDGQVYFANRTWNDYANGFGELTTSFWLGLDKIHALSNSGIPVTLRIELRGDLCEDQNGCSKQPNGYWWGEWDFSVSEFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7N5</accession>
    <name>A0A183I7N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15747</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042762">
        <property type="protein sequence ID" value="VDP23595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7N5"/>
    <dbReference type="WBParaSite" id="OFLC_0001576001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001576001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001576001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552798" evidence="5">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP23595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001576001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13028" checksum="F92C44CAEC7BDB02" modified="2016-09-07" version="1">MKNEVSLLLLLLFSTITAFRPLKIGRKQSTAVKGVLTCNGKPAVNVKVKLYNDSQGIDPMLKLYHDCDVENAQCLKKFSILIPNDFVSEGLEPKKTFDMGTLNLGGKFFDEERECAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7T9</accession>
    <name>A0A183I7T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec7_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042910">
        <property type="protein sequence ID" value="VDP23963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7T9"/>
    <dbReference type="STRING" id="387005.A0A183I7T9"/>
    <dbReference type="WBParaSite" id="OFLC_0001581401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001581401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001581401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="1">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001581401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19035" checksum="DCB0A77808F56683" modified="2016-09-07" version="1">MHMDSISGHNNHQGSTCNSVVAEVSMPSLLALNSASVAAESNESVSEDVPSIHLHFRTVQEEDAFLLFRALCRLSIKPIPERCDPTSHELRSKELSLEMLLLIVQNPSSLIHSSQPFLLGLRHLLCVSLSRNGVSPVVTVFEKSLAIFVQLVNKFKMHLKVQIENIALTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8F3</accession>
    <name>A0A183I8F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS16015</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043599">
        <property type="protein sequence ID" value="VDP26005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8F3"/>
    <dbReference type="STRING" id="387005.A0A183I8F3"/>
    <dbReference type="WBParaSite" id="OFLC_0001602801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001602801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001602801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP26005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001602801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14349" checksum="817B06C74440E2AF" modified="2016-09-07" version="1">CRKASYRDDLPDTSVIICFHNEAWSVLLRTVHSVLERTPGHLLKEIILVDDFSNFDHLKKPLEDYMSQFGKVRILRLESRLGLIRARLRGASVAQGKVLTFLDSHCECMDRWLEPLLDRIAQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8K8</accession>
    <name>A0A183I8K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043923">
        <property type="protein sequence ID" value="VDP26778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001608301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001608301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001608301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001608301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9688" checksum="E5BFB6199B7B0EB3" modified="2016-09-07" version="1">MALQSVMKYFKRREQMNSMEKSDTEDNDGAKIEVESDAQQGRDRKGRNTTGGLKEELKSIDGEAEAKLAGMLKEGENKRDGEFQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TSD7</accession>
    <name>A0A3P7TSD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS88</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000020">
        <property type="protein sequence ID" value="VDO24471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GXX8"/>
    <dbReference type="OrthoDB" id="5814573at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="269" mass="31063" checksum="B183C928336805E5" modified="2026-01-28" version="1">MESNKNQVRRSSCNSTSNSRRQSLTAQLTRTARRFSAALAPQLIKLDPLPILQNYEMLNIRLTNVTQLQAAIQRYIIKNGVSFSPIDFEVTDENDMRVLRISLHPEEMILSEGTRKILSITFDDSDPDECGTVIATIKHPISGMRIFEFLKLPSSNIIQIASHVDQCDRCQIKLISNSIFNSFTICSCFFARTKWEFIKENKIYAFIRYNGTFFDENSLRLEWVPQADNELRLIVIAFGMTQMVRDVFPSLSHIINEYNQKKIGKFLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U7P2</accession>
    <name>A0A3P7U7P2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000847">
        <property type="protein sequence ID" value="VDO30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7U7P2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO30461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="621" mass="69610" checksum="1C93D6DADD00E486" modified="2019-02-13" version="1">MLCRPNVKPPPHPDHLASLLDRRISWSSEDHHHWFRDDLQTGEECVESGSLNWALADIYLKVLYHVVHHRWMKPDVVKELLWRRHVYNNAIISLRKLFKEESARNKYEDMIAKETREENEEFEHLLTINEERNRKAAEKRNEREKEELKKMESEYLKSIEKELERKETNVKQRMKEVLQMVERSKHFVTDETLDEKIEEALENPVVYDYAIDLQGNRYYVPIPEKYIKGTPPRQKGRMYDITLGIEHYSKLREMPIPPPPPPPPPPPPPSLAPSSSSSRTGATTLQPKTNDRSKLLSEIQAGMKLRKTMTNDRSAPVVGGKISDLSENNGGTTTTGGSKIPAVGGVSGLFVNGIPKKPSDNKKANVFKGVIANAPLLSKPSEIYPTKPVTHSESQKQQFPTSLTECSKASSVNRQTSAGIADRLKQFNQISRPGLAPPTPPSLKAKPIVKDIRSPPMKKISIPEQFKTLRPNRTANDVPSLRRSGSSDDVRNSQSSLLDSRSTPPSSIPLSNPSSSIRISKPACPPPPPPNQASRIGRPMAHSSNHLTSILSPGIPSTVSVDEDSPPPPPPPRIASCTDQMDRFTFIPVSELPPPGLFSGTKKIYEYHPARKIQNAPSLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UL69</accession>
    <name>A0A3P7UL69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002142">
        <property type="protein sequence ID" value="VDO35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10583351at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="83" mass="9249" checksum="CA41E7F1F36B4218" modified="2026-01-28" version="1">MTEASRLPNKPRLSVFNVDESKINVQLGQRKNEISLQRCNIEDIPIDGDPLSSIMCMSDTYLSNVGSVMMHIMTVASQFMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VA01</accession>
    <name>A0A3P7VA01_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">EGF-like domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS2017</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001082">
        <property type="protein sequence ID" value="VDO31587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VA01"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00907">
        <property type="entry name" value="THRMBOMODULN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EMI" evidence="16">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO31587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56522" checksum="F3A26B788E3EA866" modified="2019-02-13" version="1">MQYFRTVYYRTYKNITRTRRHTTAQCCAGWVQVSGKEGCQRANCTPELCHNGGTCQPLASNKNEEICRCLPGFQGAQCQYDINECLVENGGCPHDCVNTIGTFYCRCFAGYQLDNDHRKCIDINECQFENGGCEFRCLNTEGGYRCECPPKMQLHSNGRRCVRRNICATDNGGCEHICEERHGQFHRCKCRQGFKLAADKRRCHPIDPCSTNRGGCEQHCVNDNGRAVCQCYHGFRIGPDQKSCMDIDECSTTRESGCEHECVNIYGTYRCRCRSGYRLLSDGRQCKPMIDPCQDGNGSCEQICKTEEDGNPKCSCRAGYQLISDGRSCSDIDECIKNNGGCKQLCINLPGSYHCSCKAGFLIIYDGKTCEDINECIANNAGCEHRCINEEGGYACACEVGYNLASDNHSCHDINECLINNGECSQLCKNEEGSYRCECFRGFSLAEDGKTCIGDIFHSISSFAFISLIRTSLLSDLLFAHLTIDSAPRNTHRRMCIQVCRATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VDX6</accession>
    <name>A0A3P7VDX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001380">
        <property type="protein sequence ID" value="VDO32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H4J8"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="361" mass="39909" checksum="F0E9E6549921128E" modified="2026-01-28" version="1">MSVPYFTDQSTGMVLLAGNSHLELAKLVSERLGIKLGEAVVYNRTNRETSVEIKQSVRGKHVFILQSGSKDVNNNIMELMILIYACKTSMAKTITVVMPYLPYSKQCRMLRRSSIPMKLIADMMCNSGATRIVSLDLYRKEIQGFFSVPVDNLRASPFLLQYIKENIPDYKNAVIVAKNPGVMNKATSYADRLRLGIAVIHGEQKDVEESGLEDGRQSPPLDGKPSENLTAFELFPAQVVKEKPPLTVVGDVGGRIAIMVDDIIDDAQSFVAVAQVLKNHGAYKIYVIATHGLLSADAPDLLESSPITEVIVTNTVPHEVQKLRCHKIKTVDISSVLCEAVRRIYHNESMGQMFRGVTIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W5X8</accession>
    <name>A0A3P7W5X8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger, C4 type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004462">
        <property type="protein sequence ID" value="VDO42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W5X8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="97"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33842" checksum="41E9EFDAF5E3F6D3" modified="2019-02-13" version="1">MKGFFRRTILKNQRFICRFNKACTIDKNFRCACRYCRFQKCIRVGMKREAIQFERDAIGPIKRRNDSLISRTTENNETVNNNPEVLYDNNRLMNDTLKSDVIEMLMQMEARTNQEMTTHYQNPIISSSTTVNNRADESGCVPSAFSQPHKSCSVDDLNELSRTTLILMIDWAKSLEPFPELIIDDKVILLKNYAPQHLILISAFRSSDTTPVCLFNNANLNRDERIEFDGLSAFKTSNIMPRVMDEIVWPIRHLQMREEEFVCLKALAFLHPEAKGLSSSAQTIIKELQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W8E0</accession>
    <name>A0A3P7W8E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010176">
        <property type="protein sequence ID" value="VDO57300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W8E0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="184" mass="20924" checksum="95EF2EC7D02B675E" modified="2019-02-13" version="1">MDSKCNQRKAFSFGFNSSFPFLTAIPNETVKVDVKVTSYLPKSLKNFKLHCYMKLFVQNGSQKRTAGRQPHFECTHNEVDGISRFACVWKGDIEVRKESLSGFSMNSIDESEDCLIFQSSSADELKPGENILTLTAKLMIGRSLLLRCDWLNMPEIEEDLARLPICFVHRKPVSVKLKPPPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W8T5</accession>
    <name>A0A3P7W8T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003218">
        <property type="protein sequence ID" value="VDO39593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H9Z9"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="358" mass="39908" checksum="4ACF8AFAA0CB20E3" modified="2026-01-28" version="1">MEHKAPIKITLVGSGNWGSAIAYIVGRNARKHDDDFDIEVRMWVHEEIINGKKLTEIINKQHENVKYLPGKKLPSNVIAVADLVTACGDSDILVFVTPHQFVENVCTQLKGRLKKGALAISLIKGFLIDKKEGTICLVSETIRELLNIDVAVLMGANVAQDVANEEFAEATIGYKGRKEMWPILKKLFETDNFRINLTEDSYTVELCGGLKNIVACAAGFADGLGYGGNTKAAIIRLGLLEIIIFVELFYHCSNIRTYFESCGIADLITSCTSGRNRKICEAFVKTRKSIKDLEREMLNGQSVQGPMTAEAVFIMLKKHDMLSRFPLFVVVHQICRKELSPSLLIECLRQCENKLPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WQ53</accession>
    <name>A0A3P7WQ53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007123">
        <property type="protein sequence ID" value="VDO49137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WQ53"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="190" mass="22365" checksum="39708860284C4438" modified="2019-02-13" version="1">MVIKDESTDDWERGFSDPRYVVNVSKRIQTDLTQEMLRENELKYIQLTEKLEELIEQFSAKENTMLEHFREIEKDLSAKNSLLGSLANQLEEADREATKSSEWHQKEREALQKKLYELAQVAENIPVLQYEIEKLQQEYEAGLDMTLAESLKKYQKQSDYWTEKMSATNAGSELLRVCFELTFFFSNIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YJ54</accession>
    <name>A0A3P7YJ54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003474">
        <property type="protein sequence ID" value="VDO40242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YJ54"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="380" mass="44776" checksum="F256125088D17435" modified="2019-02-13" version="1">MFFSYSQAEEDENEWTNSQLLEEVLDRLGNKKYDEVYDLIIAADYNEILAIYRRLFRVIIEEYDNDFSENGISDPILENLLLLMKSYGASNDRLMVSLQCSDQVISWKAFIMLGNFIEEILPELKDLNESFSFSIRKVYIPSWMERFEKNAVLNYPDDQSNKEYLSNLETDYLDDNYYNVELPDTSSDLFLSAVFMFLRIFTLSMSRNYGILDVLCDRILACTHIESHFLEAFMLKLDAIYRFSDRALPLNTLVFVNSFKARFCSLPRVYSPEYYLKLAIKPLRHSLHVSTSNMFNVGYVVLVLRKCLVPIKNESIERNQWTFFLGFLADFIICCEECTLCKVREACMDTFKMFLSKFEPIAQVLIIRKLFNMIRKNEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ATK1</accession>
    <name>A0A3P8ATK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040986">
        <property type="protein sequence ID" value="VDP17787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4D6"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="406" mass="46552" checksum="45B9E9480420B04E" modified="2026-01-28" version="1">MFVTIIHPDLGIGGAERLVVDAAVAMKRNGHRVQFVTNHFNPKHSFTETTEFDIKVVDVFPRSIFGFGYALCAYIRMCISALYVCIFLKETELIFCDSISACLLIFRIFRLFGLFNAPIIFYCHFPDQLLTVKKSLVKKFYRAFVDWFETWTIAMADLICVNSEFTREIVNETFPCIRTRRIHILYPTLNTKFFDNGGTAELNEIPKEARHIFVSINRYERKKNIGLALEAFSLLKEKIPENDYRYCFLVIAGGYDTMNRENIAHFIELQENATALGLPREQYVFLKSPTDEEKLELLRRAIAVLYTPSNEHFGIVPVEAMYMKCCVIAPNSGGPRETIIDEKTGFLVKENPNSFAEKMAELVKDKRKAAAMGDAGRKRVESVFAMDSFVIQLENLMCKVLSNAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BLM8</accession>
    <name>A0A3P8BLM8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041145">
        <property type="protein sequence ID" value="VDP18510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BLM8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11792">
        <property type="entry name" value="SH3_Fut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000070">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035653">
        <property type="entry name" value="Fut8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP18510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="83" mass="9400" checksum="26E7269E833636DA" modified="2019-02-13" version="1">MQPDTQSVPAQLIEIYISAHEQVAVESYRAERNNEIDLKIGDTIGIAGNHWNGFSMGTNRRTGKKGLYPSYKAREKYIVLDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FHR9</accession>
    <name>A0A3P8FHR9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041177">
        <property type="protein sequence ID" value="VDP18676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FHR9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP18676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26105" checksum="D030D60B6FD5450C" modified="2019-02-13" version="1">MFIKILPIICPFQDGSCAGTTVDELPIPKQCECQNGGVCQLNGYCDCGDFEGEQCQKGSTVSRQLIGRFGSNALLAALLFVSLLICVAMMALVGTNLYRKRLLLFKKNEAADGAVSFHGNVISFSNPVLDPKQSDATPVEYGMVQLQANSVTSSTTFSNPVYEMEESSDAQSIKSSSVVASSDSAIASRAHSFASADMKPEPSSSVIAPHSDLRPNIPSPPRRKLKERNDKTMLVSNDEVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY32</accession>
    <name>A0A183GY32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">G2F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS142</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000034">
        <property type="protein sequence ID" value="VDO24699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GY32"/>
    <dbReference type="WBParaSite" id="OFLC_0000014101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000014101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000014101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF28">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552289" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="18">
        <location>
            <begin position="87"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="17">
        <location>
            <begin position="438"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="894"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="949"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1004"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1062"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1105"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1151"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1237"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1328"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1371"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1414"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="314"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="317"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1162"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO24699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000014101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1582" mass="176877" checksum="7E90D20B1F0F12C3" modified="2016-09-07" version="1">MLFLLLLYYITLLTTRSLGAELYEFNLEHGDQMLSFSNDSYAVTLDVPIIYFEENQNELFIHSKGIVTFGKTFDVTHVSDLDQAKINAIAIFFAPVSAGKIFYRATSSDTNLLHDLTDKIRRNFPNRESSDFKALHAVVITWSDMMGEDPRQGSNQFQMILVTDGMSSYVFLIYNRITWTGRNDQHAQAGLYSSDGRRESMINSGTVSIKELVNLSNNQNEGTYIFRISGAAPEDPRGALVEDDYNYSDYEQEYDSNNEHKRQHKPLTEDCPTDPYHDQCPAECQVLTDDRGCSLCVCARLFFPFFLKVSEPPQSNKVEENVDEVDKNVVVPNEHEQSSVRPEESASKDALEEQDIKDKQPKTDDENERESKLVVPMDPENSGSIHDIEGIALSCAVASEKLQPCSSHAKCIDYDPGYCCECLSGYYGNGEECLKDGEPQRINGGFEGVINGKEMDRTELHTYVMVEEGRSYTALSQISPELGRSLLLLNAIGGAMGWLFAKVISPTSYNGFMLTGGLFNRTVNVHIGDRYMMFISGTLPKLMEDAEVIYSDHEEEYRREGPGFLRSYSSQMITVKENGAETQMKLSTDQQIHYKECPFREFTKDPVIVIHVSRIHVVYDVEEHIVRYASANMATNRDTNVMIGLSNIHGQQLLDIDQQSQQQQKHYRNQQSHRQKEDVESQRLTCTNCLQNACESGRHLCTLQNMICVPVERSYRCECIKGYQAEYDNNTELGWKCIDVPHTADMNECERGEHKCGHNAICINLEEIGVDDQIDEKAPVIGSGCLDHRDCHQWGECVFGKNGEPGYCKCRGWYTGDGVHHCGPPAETEIKQVVIEDSQPEQVEQTCGGYKCDANAYCNSSSGREQCTCQNGYTGNGISCAADVSDQRKPNVPDGKVCRSHEECGIHGNCVYNNELGAYRCVCVPPYFSDGVNCVESKGDSNSSKEFLERVPCNVVNNCNTNADCIFEKNDRGESVYRCRCRPGFSGDGHRCTMTSLDNLPAYAMLGCDKLGNCDLNAVCVLDAYTSRHYCRCLDGFDGDGYMCEVVRQNTLLPPLLPEPIDAKTCREASDCHQNAHCVVRENSLDYFCECLPGYRGDGVTRCIIADDCTPGNKQMCHENADCVFGEIERTYTCKCLEGFIGNGRQCVTQNATTCNEQPEICHHSAHCIYSRGEERYECVCKDGTVGDGYADCREEVGLHRCGVCSSHAQCVHVEADDSWRCRCMQGYVGNGNLCTLYTSCLDDRSLCDEHAECVPNEYGHYVCNCHYGYHGNGQTCIPDSESRDEAIFICRGMTIIQKSTSPGLPGKQLIVVPHQIAVGIDFDCLEERIVWSDNAGHSILSASINGTDEQKFMNSVLKSPEGVAVDWSSRNVYYADSVKDEIGVLSLDGKYYKTLINEGLVNPRALAIDLIDRYLYYSDWHRENPVIGRVRLDGTEKSAFITTEVHLPNGLAVLLERRQLCWVDAGLQQLSCIGLNGNNRRIVYAPLQYPFGLTVHNEQRFYWTDWSDNKIHSVSVNGDGYMSFPATIGGSGRLYGLVSVPLRCKGVATACAVNNGGCEYLCLPGKTDVTCACPDNIDRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYF5</accession>
    <name>A0A183GYF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NOT2_3_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS265</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000075">
        <property type="protein sequence ID" value="VDO25189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYF5"/>
    <dbReference type="STRING" id="387005.A0A183GYF5"/>
    <dbReference type="WBParaSite" id="OFLC_0000026401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000026401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000026401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="288"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO25189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000026401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47687" checksum="95615E70EAE896E7" modified="2016-09-07" version="1">MSSSGGILADRNRLSSQSSTPSTCRNSLIPPENVINDSEFPSLGVRSSPSSTSSTFNSLPTTSNYSSSPPVSQNHLYTKDVYNALQRTPYGKLFYSENSIQQIGDDNYRKFHYRKIANLMRTSDGNSLSAQNVEFRIQNEDFPALPGANHLDNRQTHVRTKNNIDGLASETRYSERSNTETKASIQTFPDGTVKNIPAGMLSDQFGMAGLLTFLRAIESDPAIVALALGHDLTTLGLNLNSTERNIYATFGGPWADYPCRIQDLEAKAGFYDFLCLMIRFQYLSYYLPVPEEYLTNASIRDKLPNIKLSKLSEDVLFYLFYNCPGEVYQVAAASELYSRDWRFHKSQRVWLTRSQYGGVKEQTSTYEKGSYNVFDPVQWRKIPRDMTLEYKELEERPKLPQSLQQSGQPQVAQSSSAAASQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYM8</accession>
    <name>A0A183GYM8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone acetyltransferase type B catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS338</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000104">
        <property type="protein sequence ID" value="VDO25462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYM8"/>
    <dbReference type="STRING" id="387005.A0A183GYM8"/>
    <dbReference type="WBParaSite" id="OFLC_0000033701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000033701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000033701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="7">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000033701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35503" checksum="28B3A12FC26C8337" modified="2016-09-07" version="1">MEMLCRTSAIFKSRLDDQRNFWPYGQLLSKFTAGNRELQVWMVNESSPEFDAYLARVQTLALWYIEAAQYTDNDDPRWQHYFLYESFKKSNGVSRVALAGYASLVRFYNYPDKIRPRIAQILLLPHYHGVGIGAKFLKAIYNDLIQDPKVIDITAEVPAKSFITTRDYVNCCNCSTLKEFHADNLKKGFTEEMKSAALLRFKINPKQTRRVYEILRLHHIGVRDEEAMEKYRLDVKKRLEKPFKRSERDWKKLSSVLDEYEYAAVVASQMSAEQKTAKLEQLYEEELTSYRAVIKRLINFANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYZ4</accession>
    <name>A0A183GYZ4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS454</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000149">
        <property type="protein sequence ID" value="VDO25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYZ4"/>
    <dbReference type="STRING" id="387005.A0A183GYZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000045301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000045301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000045301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000045301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34469" checksum="D8CB9424420BEC87" modified="2016-09-07" version="1">MELDIAKHFQQLLEGKDNSKSIGQAAIETLMQCIEISKAKTVNELTDELRNAVVAMSTTDRSIPSIRSASELFLRFISLATPEENVQEFSILMNKYKERGNIFIKRVGLSKTMIAYFARPFIKNNMRILTHSYSKVVLEVLLHARKDGVNAHVFVTESRSDESGIIMIKALKDVGIQCTLIMDAEIGYLMETIDLVMVGAEGVMETGGIINKIGTHPMAVCAKAIHKSFFVMAESIKFVKEYPLSQNDIPIEFKYTASTLKKHKLDGDFSNEHPLVDYTPPQYINLLFTDLGILTPAAVGDELLKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZK3</accession>
    <name>A0A183GZK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS663</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000241">
        <property type="protein sequence ID" value="VDO26615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZK3"/>
    <dbReference type="STRING" id="387005.A0A183GZK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000066201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000066201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000066201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015291">
        <property type="term" value="F:secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO26615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000066201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="50865" checksum="3319181E36D94801" modified="2016-09-07" version="1">MYDQVSGDRTAGYVLPADMKLLQQDIESRLISCDKLWSRQECRLWTASLFLGTCMLYAARVALPVCATVIAHEYSWNKNDAGTVLSSFFWGYACTQIIAGHVADRVGAEKVLKICTLTWALLTFFTPLLFDLSYSTNHPMLFVILIRSATGIGQAFHLPSMASMTSRHLTSYDKGRILGICLAGSHLGTALAGAVGSILLETFGWRALFQCVGLMSFLWWTLLRFMSSSSHQSGSFNDDKSDELKAPLVSDLRKSLGNSCSENVVPWSVLLKHRSFWAAAVAQYCGANAYYTLFSWLPYYFADTYPDAKGVVYNVVPSLAIVITAFFAPFIATTLFVYVHSLTLARKLMEGISLSAIAICLLISTQSMGFNASLFTFTLAMAARGFHHGGVSVNPCDLAPNHTGSVFGVFNAFSAITGFIGVYLAGYILHETGSTWAYVFIFTSLQCFIGAIIFSLFGTANRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0K7</accession>
    <name>A0A183H0K7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1017</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000429">
        <property type="protein sequence ID" value="VDO27893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0K7"/>
    <dbReference type="STRING" id="387005.A0A183H0K7"/>
    <dbReference type="WBParaSite" id="OFLC_0000101601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000101601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000101601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000010">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="222"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="573"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO27893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000101601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="72584" checksum="789049C0EFD049F8" modified="2016-09-07" version="1">MFRANRGDTMLICTSKEIRQSKLAAVTVLNGWTVFIKPDYSIYRSTTTFAICLVDLCLSYKIIGTSNWLSGEERSRLEAVQRDWRLSRPAKPYSPWSRYRQPSIDKSSKSPGTIARKDSAAHQHTLFERNRIPAAPSLIISGTEGNKKTKIHETVNEEDEKEKIEENSAIISEIPLPLLSYESEKKDEELTRTEEKQREVVDDDVDAEEEKPIDKSPDGRFLKFDEELGRGSFKTVYRGLDTETGVAVAWCELQESKLNKAERQRFREEAEMLKGLQHPNIVRFYDYWERQDHAGKKRYIVLVTELMTSGTLKMYLKRFKRINIKVLKSWCRQILKGLSFLHSRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSYAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECQFPAQIYRKVTTGVKPECFSRIPQQYPEIREIIDRCIRVRREERSTVKQLLSDDFFTPEELIGIRVEIKNRDADLCDVNSEIQMQLRVFDEKKRKQYRFKENEGLQFAFDIETDKAEEVVQQMIEQQHIPEEDTRMITKLIKDKVEAFKRDREFRHAELKRLREEEQRKQEEEAIRNEMLLRAKEKERMSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V0</accession>
    <name>A0A183H0V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000477">
        <property type="protein sequence ID" value="VDO28287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V0"/>
    <dbReference type="WBParaSite" id="OFLC_0000110901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000110901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000110901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000110901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39061" checksum="BA498B713F59991E" modified="2016-09-07" version="1">MTHLEKNINVENTPQNQLIIDDEDSNGAINIADNRFVMDNQMQATPSYLKSYNTHCNRELQTIIQNKISAFEKDLLEYISGKKYINEATQTDQISGNELNNESNNDSNTLLKKQIGTPENTALKTSLSMNPTDDMITEQSTAENILFDEELLLDEPIKPFESLPLLPRRKSLLTPRNILNSNTPAKSIQRSTSRRTTREVVRSIPAMISKPTIASEMKQRSKSINSVQPINPSKKPNELPLETRASRLKAEYLAKKRAAEANADKSRMTGIRGTTSVLANHSLTMPRKTSFTSIRSAKFYNIRESNSLNVNNQLSTFGKNILPPSEETPRNTNRRRGKKKSIRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Y2</accession>
    <name>A0A183H0Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000497">
        <property type="protein sequence ID" value="VDO28405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Y2"/>
    <dbReference type="WBParaSite" id="OFLC_0000114101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000114101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000114101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000114101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15225" checksum="6D19A388B150A40D" modified="2016-09-07" version="1">MDDASCGKKRSTPQFTIERHKSGDLAQCIFWSERSKINYLWVLLSSFWDWNPFAATGLKPTYGHGNTCKENGIISRVEEPMLWLGYVSISQMREFLSRYLCLSSNVSLKIDNTLALADSEYFPKIPHVLLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H385</accession>
    <name>A0A183H385_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1945</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001033">
        <property type="protein sequence ID" value="VDO31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H385"/>
    <dbReference type="STRING" id="387005.A0A183H385"/>
    <dbReference type="WBParaSite" id="OFLC_0000194401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000194401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000194401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000194401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41292" checksum="32C5DE4630711A1A" modified="2016-09-07" version="1">MHAVQQYHISLLCGRLCFPALSTRHVMEMSGPGDFVADNLATGGAVCGTAAAAITQETSSSGTPAKKPKKACRARTGYMLFHGEARKRIRAAHPELNFVEVSKRVGEEWAKVSAEEKNKYKLRAEQIAKEAKEDDSQKIILPPPGRILVYQCMWQKCDIQADTSDALYEHIKTTHNMEYFSQGEKRYACLWSTCFRNKRYPRSFSLLPHLQQHIKYKHLPRCARFITPDKKSKNFFSLTSSAPTPTTESTSSVRSYARKTHPLVTLHTPFVLPSSHGQMQIAPAFMIPQQQSSNFPQDGFAYALSTNTSGQSFADGGVAIAMLEQEGNKGPPNSDSSTLQQAFYSGQQYLPNSNSAWTVPNKGARSPEFSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3A7</accession>
    <name>A0A183H3A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1967</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001047">
        <property type="protein sequence ID" value="VDO31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3A7"/>
    <dbReference type="WBParaSite" id="OFLC_0000196601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000196601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000196601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000196601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13482" checksum="DB2AC7F594138F34" modified="2016-09-07" version="1">MSALVTIAIYHQQGNGRLRRHCHMKHTRMSSRYNILHILHRAFTLLLILSARLASSSPLVRDPSFAAVLCRTQFPNTNCLQRAHNITSMKYQPEQLHFKPAFLGSPSDASQMLVPLGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3G8</accession>
    <name>A0A183H3G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2027</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001089">
        <property type="protein sequence ID" value="VDO31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3G8"/>
    <dbReference type="STRING" id="387005.A0A183H3G8"/>
    <dbReference type="WBParaSite" id="OFLC_0000202701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000202701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000202701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000202701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35001" checksum="C200FE6E715ABB5B" modified="2016-09-07" version="1">MANDIASDTMDDNKDSEGNAATMQGTISAGQKRTRDERGGPALKKAHVSDTEDNMVQVKVLIPSAAVGALIGKGGETMRNLKSESGCRLQMSKNQEVYPGTNERICLVKGKIASVLKVSDVILEKIREKVDNNTPSDIFDHKGMERKNEMKLVVPNTSAGMVIGKSGARIKEIREQTGANIQVYPKAGSQEAKVSQERIITIAAEQDEVLMDALQRVLEKVAADPQHAMATAPDHKDDSFGPASGLLHGIGGGVQGQTIQPFDFNNRSQNAPQFGGAPTVQQNHFGQISHGAAQVWQPNQQRALGEIWWTDNDDSRIVKRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3X1</accession>
    <name>A0A183H3X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2181</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001199">
        <property type="protein sequence ID" value="VDO32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3X1"/>
    <dbReference type="STRING" id="387005.A0A183H3X1"/>
    <dbReference type="WBParaSite" id="OFLC_0000218001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000218001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000218001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000218001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31878" checksum="0CBA1F8D31E524D7" modified="2016-09-07" version="1">MFQVDRVVSLWKEKISRKILEGQKNIGESLAEPSKYPNLFSGFSESLKAERFLKELAKLPIKASAHSPTNAQRNILEEMAEAEKSGTLIFHEDGTAELSKNGNAVLNSSIIEASIISTDSTLLSENAQTVPNSSKTLLTTSTSSLLQIPSRTPFNSAVTLVSQTDSTSLTSDSYKYLSEQYVRTKPISHNSAPLSADVNSDISEDGEVEERNLMDAGMGPDIVRDRARPDIVPSNGGPDVVGSAVQPQPEVVQDAEIRSQEGIITWSDDEDEDQFENDAAFNIDDLNLENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4B3</accession>
    <name>A0A183H4B3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carnitine O-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">OFLC_LOCUS2323</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01001310">
        <property type="protein sequence ID" value="VDO32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4B3"/>
    <dbReference type="STRING" id="387005.A0A183H4B3"/>
    <dbReference type="WBParaSite" id="OFLC_0000232201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000232201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000232201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="115"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDO32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000232201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="66042" checksum="F458A3560DD4A010" modified="2016-09-07" version="1">MCTIIFAINLLSAFHYDLSFGMVYLLQHNIFSLFFGNGMFSQALSLMLYGIFVWFMIIQFIRLSLKCFLLYKGWMYENPHLQPLSKASKLWLVILHLLSKSGLMLHSFQAALPHLPLPRLNDTLDKHLCTMRPVCTDKEYDELVQLTEEFRNGIGRHLQWYLIIKSFLSINYVADWWIEFVYLRQRSPIMINSNYYGFDSIMAHSTHNQAARAALVTWAALLFRRKIERQEIKPYKIPFCTAQYERLFNSYRVPCLEKDRFHHWNDAKHIVVYCNGHWFRLAIHNGKRLYEPCELQKGFEAILNEKVNSDVDEKYIAALTAGDRDVWAQARRNYFASGINQFSLHAIEKAAFVVILDENEVFYDPNDSSKLDYWANSLLHGTGYDRWFDKSFNFIIYKNGRMGVNAEHSWGDAAVLAHLMEFCVIKSIGKNNYDENGNVNGKVELIPKYELLRWHIIPELNITIKKCFQTACALIKDVEMAVLIWTKYGKGFIKKLHVSPDGFLQMVLQLAYYRNQRKFALTYEAATARLFREGRTETVRSCSSYSCDFVLAMLDPNQTHFIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4L6</accession>
    <name>A0A183H4L6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2426</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the cullin cul-3. Interacts with ubiquitin via its UBA-like domain. Interacts with ned-8/nedd8.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001394">
        <property type="protein sequence ID" value="VDO32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4L6"/>
    <dbReference type="STRING" id="387005.A0A183H4L6"/>
    <dbReference type="WBParaSite" id="OFLC_0000242501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000242501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000242501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14350">
        <property type="entry name" value="UBA_DCNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000124">
        <property type="entry name" value="Defective in cullin neddylation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00059208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00064502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000242501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29660" checksum="BF9036291963DDFF" modified="2016-09-07" version="1">MASNFSSVLNYSENFFTVAQSVKRAKLSHSAMNKLKTAQRDKVRNFMQWTQSNEKTAIHCLSSQNWNLELACDAYYQNPQLYMCMADVVDQRSLHAFFLKYANNRQDNDPSCIGPHGMLRFLTDLGLNPTDRNVLILAWKLKAKTQCEFTWEEFSTGLNEMKVDSLEKLKAKIPTLNEELRNPINFRDFYQFTFSYARASPQRTLEVETAIAYWEIVFGGNFGYLPLWTSFLREKVCILSIIILKFLCSNMPKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N6</accession>
    <name>A0A183H5N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2796</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001699">
        <property type="protein sequence ID" value="VDO34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N6"/>
    <dbReference type="STRING" id="387005.A0A183H5N6"/>
    <dbReference type="WBParaSite" id="OFLC_0000279501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="69526" checksum="DBBF27FD4FB9A2D7" modified="2016-09-07" version="1">MLKHTVEYSREHGQRTLKKYLRYNEKEINFNTVTVYRDREVKVDVGASSNFDLIRYGKVMFDCRKGQTFWNCETESNINNQYVIKGHETLSPQNTDIGYLQASKYNANAMLRRAEIVYNLEMDVNGDRGMIKLQTPTHAIDIPQVRITRKGPTEFEIYTESGSRGRIYAHVKTGDYDKLLKIQITEIPEPFELHLENSLTDGKQKSTAELTLGPLGQKRTYGIENEIEGEGERFRALRLTLKRPKRVIKIQLLRPARNKYALSILPNVGGGRLPTVAEMTYQKTTNGYHWEGSFSDQALKTPLKAKIVHKKDVRDRYNYRLDWQTEFAYSDEPDKLFSNSLHLHRSVVPSTRRQRSAITRGERDDNVRFVVELKSVHLASNLNTRLWTKVDRSLIGEAAIPVHATFGLETRNLQRQPVEYSLEMRTDAVKFTEIQLKSPSSLLKARIDKTSDNHYKVGIYENSERPSIVGELNLNDNGPVFEYRDERSQEVKLHASAQKLNDYEGKIDVWHSEASKKIQDALLSLQVKEGNVWKSEIYIRPTMESEIVKKAEEAISKTDEFQRCAFMRDTFLPIFSSHKQIANDVATAMDRVIKEWTKEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Q9</accession>
    <name>A0A183H5Q9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2819</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001720">
        <property type="protein sequence ID" value="VDO34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Q9"/>
    <dbReference type="STRING" id="387005.A0A183H5Q9"/>
    <dbReference type="WBParaSite" id="OFLC_0000281801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000281801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000281801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF3456" evidence="3">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000281801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9691" checksum="B52FE5CDF488AF16" modified="2016-09-07" version="1">MYVLYCAVELGMPYEMWDSPSVEIVTLKQNCETLLEHYEDDLEQWYHIQDRPLLEEYLCKKRILKRTERSCMDTANNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H619</accession>
    <name>A0A183H619_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdate transporter 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2931</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001822">
        <property type="protein sequence ID" value="VDO34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H619"/>
    <dbReference type="STRING" id="387005.A0A183H619"/>
    <dbReference type="WBParaSite" id="OFLC_0000292901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000292901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000292901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF23">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000292901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37714" checksum="8554D55B9F078291" modified="2016-09-07" version="1">EPKFSSNFHANELINRLILCCSGRRSSCLLYAILYAGTCVAKHFANFWILFIGRIFGGMATSILFSAFESWLVCEHNKRGFNPDSLKTIFSHAALANSIVAIIAGLVAQYSANAFGYVTPFDVSLAVLVVMMVCTIACWTENYGCEKTTLNLQFMDAYRAMRNDWRVVCLALIQSLFEGTLYLFVLEWTPALSDASGALIPHGYIFASFMVSTMIGSTIFRLLSEYQRPESFMRFVLALSVLCLVIPIIWPDHAAAIFAAFVFFEICVGIFWPAIGFMRGIYIPDATRATIMNFSRVPLNTVVIIILLQNLSRQTVFQCCVMFLVFATAAQQYLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H638</accession>
    <name>A0A183H638_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001837">
        <property type="protein sequence ID" value="VDO34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H638"/>
    <dbReference type="WBParaSite" id="OFLC_0000294801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000294801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000294801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000294801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15035" checksum="3304891E24D0DD9F" modified="2016-09-07" version="1">MWFLPVIWGVIDLRSFIEYIPRPHSLRVHFEDTVPYSFCMSTYMHLPLLRLALFGCSFLRVSSQQLMASQLIVEASRNCVPSCSIAVHVLWSSVVIMDSVLSNSILLALALHRAIFRYNRHFTPTPSISEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H722</accession>
    <name>A0A183H722_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3284</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002150">
        <property type="protein sequence ID" value="VDO35967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H722"/>
    <dbReference type="STRING" id="387005.A0A183H722"/>
    <dbReference type="WBParaSite" id="OFLC_0000328301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11827" checksum="C609E96287EF3FC3" modified="2016-09-07" version="1">MPPEDLSLLTVGEYRKNRKEELPSRIPSLHPTVVIAGAAKNLCLNEIASTVSFSISTMKRKKSTLKGFCSGLYRVSAAANGSSLNDLETDGDGGVFLLNFEKLNREFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Y0</accession>
    <name>A0A183H8Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3942</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002813">
        <property type="protein sequence ID" value="VDO38310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Y0"/>
    <dbReference type="STRING" id="387005.A0A183H8Y0"/>
    <dbReference type="WBParaSite" id="OFLC_0000394101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000394101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000394101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000394101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12512" checksum="35F3861DD8A28C5A" modified="2016-09-07" version="1">MNNNDNTAPEKANIAISGVQTLNWNSSVNNWMDYENENHQDSGTSSSDGIPTSDAPTSSTTSTNITIFDAFLQAIDRNEISSRPDLETRLKIMNWLCATEEINRIVSFHLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H967</accession>
    <name>A0A183H967_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4029</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002909">
        <property type="protein sequence ID" value="VDO38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H967"/>
    <dbReference type="STRING" id="387005.A0A183H967"/>
    <dbReference type="WBParaSite" id="OFLC_0000402801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000402801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000402801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF12">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000402801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28513" checksum="EB081701A00325B4" modified="2016-09-07" version="1">GTFTLSEIYGRSNREKIDKLPNFIAWDTHKLAALQFTSGISAPPKLVALTHYQLLNGCHAVIKAIGCNDISCICCALPLFKMPIFSLIGLVPFITNTRVIYPSPSPLPKFLFESVKKFQCTHLVSNAVALGLILRVAQIQNVRLPSIENIILLGDRIPSDVIKNIIKQFENVQKVMNGYILTEVASTPILTWDTMNVKGVGKPLDEFSVEIRSLGIQANWKGINKQSGELYIKAFKGSKFLGYETPYEGGEEWIETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9F4</accession>
    <name>A0A183H9F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4116</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003007">
        <property type="protein sequence ID" value="VDO38947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9F4"/>
    <dbReference type="WBParaSite" id="OFLC_0000411501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000411501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000411501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000411501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34296" checksum="C7981311004D02AD" modified="2016-09-07" version="1">MRQLNHFVFPPSLKCRLSIIKREVRQSLANESEQIDDDLIDRCVEVGVGAVGTSSPIRLIGVAYNLYKQQLESSDLEKERAGRKHFALKFLDETISDVDRIFCYIMYKLPDGTPTPTKKIREVVNETKCADLEEWKEKAYATFAAIPPVKVDVKIVLQDLYIASLRSLTHNDFQMLKEKDIDCLVVYSEFLDFGFDLKRLLPLFDEETMIIIQNPSVLSISMDVFARMHKWRCKESRVCVACDTDGLTMSGLIVARYLSLSTRCNHEDAIKAVKISHESFFPLPYAKVNFLSAEFEVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9G0</accession>
    <name>A0A183H9G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4121</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003012">
        <property type="protein sequence ID" value="VDO38969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9G0"/>
    <dbReference type="STRING" id="387005.A0A183H9G0"/>
    <dbReference type="WBParaSite" id="OFLC_0000412101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000412101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000412101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000412101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25952" checksum="34A81E13932B9314" modified="2016-09-07" version="1">MIHFQKHGTTQKPTKPITLNVEDQQKIAKVGLEMKLLTSEVDAEAEKWDEYAENDIVRRAKAMSSMAYNMYLFTRGDGPLKTTHDLFTQAEFFAEQANKMFKAVQEFSCEVPGSAEKNDLSTILEKIPTHCQQLQVLVKSPTVGKPATFSKVDSVIQETKDLMNEIAKLVTACFVCATKFAIEFHGSSIPRQTIDDGEFAQRSSRESTLWRRTPSMRRVTQAPAVQVRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA30</accession>
    <name>A0A183HA30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4340</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003251">
        <property type="protein sequence ID" value="VDO39688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA30"/>
    <dbReference type="STRING" id="387005.A0A183HA30"/>
    <dbReference type="WBParaSite" id="OFLC_0000434101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000434101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000434101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000434101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26538" checksum="354E33AB0AE5E621" modified="2016-09-07" version="1">MAWKFRGNTDFDLNAGRNAFRSDASVDDWENADTETIMRRNSAIRSFTESVDSDFPPAPELPPSLNIDLHYPKEAMRRSETSETVIEKPKPKPKQSLQEVVSGTQKYPMMVPGPGHIDEEQELHASLLHQDDEGSESDVEISNFERKQSLNTASKKKQQKGQDCDHEALRREYSVSTLERPRPTTPTSWCAIENYVEDSVEAENESLATAAKKQKIHVSIPNHNTPQSMSLNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA82</accession>
    <name>A0A183HA82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4395</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003312">
        <property type="protein sequence ID" value="VDO39854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA82"/>
    <dbReference type="WBParaSite" id="OFLC_0000439301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000439301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000439301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000439301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7663" checksum="2BA3B8645C0B6539" modified="2016-09-07" version="1">MELSSDSYEKSHVDCTEIEKRLIHRNYYWYMKGKEKRQQSGLAPFGFDHLPAQTVLCVVKIPMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAB6</accession>
    <name>A0A183HAB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4426</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003352">
        <property type="protein sequence ID" value="VDO39969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000442701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000442701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000442701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000442701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13734" checksum="2B5DBB5AB6D66558" modified="2016-09-07" version="1">MSRLKSCQNIKLESSGSYINLSDFLITFLLLILYCIAEKSSSFDVLNRAECQQSSIIRSLSNLSFKLPNSKSGDFVDVTGHNDIKFDSLTIPFIHFGMERVTVSLSALDKEFETARCLVVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAQ2</accession>
    <name>A0A183HAQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4565</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003521">
        <property type="protein sequence ID" value="VDO40351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAQ2"/>
    <dbReference type="STRING" id="387005.A0A183HAQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000456301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000456301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000456301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO40351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000456301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18403" checksum="84A08C9D4FA5D0CD" modified="2016-09-07" version="1">MIPRLQCPICLDALALNESSATCCGHTFHQSCILRWLKNYETCPVCRKEITTLIQQLFFQMEENENFNSVGTDLFKMHNELQNALKHLQEVEQAAAKAKDEANFFLTANLLLKDQVTNLEMISRLNVQQINNLKSKLAQQMNKEKELEEYKKRLQAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAT7</accession>
    <name>A0A183HAT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003565">
        <property type="protein sequence ID" value="VDO40454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAT7"/>
    <dbReference type="STRING" id="387005.A0A183HAT7"/>
    <dbReference type="WBParaSite" id="OFLC_0000459801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000459801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000459801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000459801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30097" checksum="ED8972FD6E6EF64C" modified="2016-09-07" version="1">MKNLIKGDKNICQIIYDHCRAHYLVLFRNKLNPKRIIVYDPIVPHQDSVRETLNDSVREQILTMFGHLYQDDELVEIAVETGLSTQNDCWSCGLRAVAFITHLLLGINPANYEYDLEEVGKFITQVIKMDRPNRNVIASGQFGRERKDSKSSLTIVRVTKGGNFSIENGTTCVLSKQPSMESLPNDGNDGKDINILKKVEEKLSKLKDDNKSDESSDNNDEDKNRRKDDYLSACKSNQSIKSSSSENNSSEYPKSDNESLSIISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBD3</accession>
    <name>A0A183HBD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4796</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003831">
        <property type="protein sequence ID" value="VDO41080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBD3"/>
    <dbReference type="STRING" id="387005.A0A183HBD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000479401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000479401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000479401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000479401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33850" checksum="56A42B56700E5CC4" modified="2016-09-07" version="1">MYCPIIFHKRCITNFQRVYPSPSKRRMDSKGECEEITYPRIYFAIDDFEEIFNDVVVRDGECVCVELVAKDRSRNCEAVIFLGSIRYEVLKQAYDARASFSWQWAQKFISPNQRRREFVRMRGPHGKGYAEMAVMRLPNCDYETPLSEQSLGFESLGQCGIRRMSDTNLNHYPQRLMVTSGLSDGHDPSKGRRWQSETDTLNEYREVEASSIDDVLNEGMMSRLWSVRGFGQAWHWLREKRRAESLPLNAFLTYITLPWSTILDDLLMERPRRPILTFDLGNLELKSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBX2</accession>
    <name>A0A183HBX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4983</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004070">
        <property type="protein sequence ID" value="VDO41675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBX2"/>
    <dbReference type="STRING" id="387005.A0A183HBX2"/>
    <dbReference type="WBParaSite" id="OFLC_0000498301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000498301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000498301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000498301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32968" checksum="1EAA172B93CC9939" modified="2016-09-07" version="1">MKLDKYSIFCETYVAFFIHTILKKWLEFLETKFYVIRAEGEGKDIVHSLKGVMEAIEFAYLRDFVIMVADRDRKDEYEALEVHRIKKVATIKYAGIVQARKQFFRLIRRITAYGSIIDSLPQNTCTIFKLTYYEEKTPSNYEPQGFMADESLFHFPREVEPLTFGRFDCEKHMVTTSVHSVFMKSAIEMKSLMHANATKFNSSISRGTTICSSPTKTLRTLSACTDEFSLVQLKTFVFSLQEDDDIEQQNDPMESTELSSSFIDISGTIQITEICTIMRIIRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC80</accession>
    <name>A0A183HC80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5093</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004201">
        <property type="protein sequence ID" value="VDO42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC80"/>
    <dbReference type="STRING" id="387005.A0A183HC80"/>
    <dbReference type="WBParaSite" id="OFLC_0000509101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000509101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000509101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000509101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48283" checksum="3D6F957C69F51878" modified="2016-09-07" version="1">MNFRTFAYCVRHLIRRHEANREQGTVFDIYFTIKATCSKEGDLPEVFAIISPIHASLFYLALVRECVCYLHDSMERLKNFLNVVYRCTFPTDGNSLHIFEKIKDGTKRNIVIRGQGPILGQSDCSAFVRRMGPEVTVAVIGALLAEQRVIIAGGSVQCVCHAVQSIACLLHPFSWPYTLIPVLPDSLLEIVNSPTPYLIGLLRTNMYRLKALVVKDKNRYTDDLIQDDLVIVDLDGGIFVPQLTKLCAANENIDFKAKNAFALCEKLLIPRKLAINLVTKLKEAVAVGEGSRADFLLQKAMLSWFAALIWPYKGCSFYAAFIAESNGDFESIRTSKAQLVASHTSKSARRFTEWFVETGIFREWIRRKVTSAPEMISAIPHIAEDVANQKFDECVIAITPQVSQMRMANIFTKAHNVIFRSHLLKKLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD97</accession>
    <name>A0A183HD97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5459</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004701">
        <property type="protein sequence ID" value="VDO43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD97"/>
    <dbReference type="STRING" id="387005.A0A183HD97"/>
    <dbReference type="WBParaSite" id="OFLC_0000545801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000545801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000545801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000545801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16813" checksum="201B5120D6DFB604" modified="2016-09-07" version="1">MKRRSIVENSMTSSSSDHDSSASLPSPPKQALMDDDFMKTLEQLSKQQSSQLLTNVEQSIAPQQGNFRTVLKRPDLKGSFRCSICQKIFCHSSSLSRHRMQAHFKSYTCTLCRKEITNLKLNLKELLLNIIEQFHCMIEKFNQKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEA4</accession>
    <name>A0A183HEA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005208">
        <property type="protein sequence ID" value="VDO44441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000581501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000581501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000581501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000581501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="4907" checksum="9810E012ED07783A" modified="2016-09-07" version="1">MFPGAPASENRKEATLPEPAKKRPRIQESRSSVSLRALLDVCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEI4</accession>
    <name>A0A183HEI4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS5895</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01005321">
        <property type="protein sequence ID" value="VDO44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEI4"/>
    <dbReference type="STRING" id="387005.A0A183HEI4"/>
    <dbReference type="WBParaSite" id="OFLC_0000589501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000589501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000589501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="216"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000589501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35550" checksum="AF779B56773A9238" modified="2016-09-07" version="1">YLEKDSDDELEYQPVPGSPGANASSYGGGFNDDDEEDPLDAFMADVNKQAKQDKAESERKDKERCVKIEKGANLEDEKDKGLGRADIDDEDMQESYFKFMEEHKTNTVEDEIYEYDEDGNIIWTWKKVIDPLQPIDHATMEYAPFNKNFYHEHEQIKSMTTIKVFELRNNLNLKVAGFNPPKPVTTFAHFGFDEALMNVIRKSEYEHPTPIQSQSIPAALSGRDVLGIAKTGSGKTVAYLWPAIIHIMDQPDLKEGDGPIALVIVPTRELALQVYQEAKRYCKVYNINVVCAYGGGSKWEQQNALIEGAELVIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF91</accession>
    <name>A0A183HF91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasma membrane fusion protein PRM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6153</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005703">
        <property type="protein sequence ID" value="VDO45599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF91"/>
    <dbReference type="WBParaSite" id="OFLC_0000615201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000615201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000615201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000615201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23143" checksum="B3DC22E286B33EE8" modified="2016-09-07" version="1">LIIIYNRIKCSSKNVEKTFDKVEEGFKIAYSRTLDLYNQYHQSNVNDQAKHILEKIFTYGLSIAFIMIQLNLTILVAILTMLLNAILSGKEALDHACKSTSNAQAAARQIVTDLSGKVQEISQASTEKIEKQANRFLDEANRVAHSRMGVSPESDDAEKRPWNRLQDLSHRILENSMNRVEGLCWTRFDPRSIVECLTNSLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFC7</accession>
    <name>A0A183HFC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005746">
        <property type="protein sequence ID" value="VDO45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000618801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000618801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000618801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000618801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21205" checksum="B3064D7DC8D1D7E9" modified="2016-09-07" version="1">MMLVGIDSLDEIENEILLINSTAWLQQPSDPKDWKEEIAKFRDVYQTFEFDEASKQLEALKVKGNAFAMEKDMNKRNAREKWRHLPIIRLRIHRIEQNILDNDSFGDNFHVLQRVDRVRNLANEISKVLQEVYNYYNQMDNELSASYNTLTNIEEKLNEKREKKERIQSSKCFWIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFK3</accession>
    <name>A0A183HFK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005853">
        <property type="protein sequence ID" value="VDO45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000626401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000626401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000626401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000626401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9244" checksum="6CCDA123087924E4" modified="2016-09-07" version="1">MTMELISNLFEGKREEGIFHYHYDDHQNHCQQFGLSDNESLARMSLKGPGECYVNWNKVALDMATFDVTRSRIFAPESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFK8</accession>
    <name>A0A183HFK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6271</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005863">
        <property type="protein sequence ID" value="VDO45979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000626901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000626901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000626901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552513" evidence="1">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000626901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25159" checksum="91645082A978465F" modified="2016-09-07" version="1">MYSDSLNKTLFLIAVSPSVASASYVNVLTDPRSLPLSNAPSMASCCVPYVNDMDEECLHSQSEPSVLSIGHGDKSSDVLLNSSIRNRNIPAFSNAATSNKFLSRADSWPRPLTDEVIREREMSVRTREWCAVNGRETKGRFVKQEKKNTLGSKHYECGSFRRQSGRLPKRSRSLGMESRYLNSSREKNWNRAKRIIGGVRKSINDLNACKFSASLDKLALPAMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG13</accession>
    <name>A0A183HG13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CARMIL_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006107">
        <property type="protein sequence ID" value="VDO46511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG13"/>
    <dbReference type="WBParaSite" id="OFLC_0000642401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000642401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000642401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000642401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6702" checksum="5ECE7B18048B1C6D" modified="2016-09-07" version="1">MLQMEIKDDLSTLRSSTRSGSPTLSTVSSETNDKRRSLRGRRSSMSVKQVVDGIEITVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGF0</accession>
    <name>A0A183HGF0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cytochrome-c oxidase</fullName>
            <ecNumber evidence="5">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cytochrome c oxidase polypeptide II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS6564</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01006309">
        <property type="protein sequence ID" value="VDO46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGF0"/>
    <dbReference type="STRING" id="387005.A0A183HGF0"/>
    <dbReference type="WBParaSite" id="OFLC_0000656101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000656101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000656101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000656101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10602" checksum="20E4C65462991467" modified="2016-09-07" version="1">MKSLDDLSVKKIRLFDADNRCVSPVGVNVGVYCTSGNVIHSFAVPKCFTKIDALNGLLTKVTCNFSCSGLFFGQCSEICSANHRFMPIVLKFTSLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGU7</accession>
    <name>A0A183HGU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMG box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6710</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006544">
        <property type="protein sequence ID" value="VDO47624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGU7"/>
    <dbReference type="STRING" id="387005.A0A183HGU7"/>
    <dbReference type="WBParaSite" id="OFLC_0000670801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000670801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000670801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO47624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000670801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13026" checksum="F31EE460984970FA" modified="2016-09-07" version="1">MGKATVDGKKPKAVKKMKDPNAPKRAMSAFFIWMNENRDRIKKPGMSVGDVAKAAGIEWAAMTDKSVSFLFLIKNYRKKRKHHNGNILQWEKRAEEDKKRYEREIAAYKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGV5</accession>
    <name>A0A183HGV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6713</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006552">
        <property type="protein sequence ID" value="VDO47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGV5"/>
    <dbReference type="STRING" id="387005.A0A183HGV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000671601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000671601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000671601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000671601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11592" checksum="4824778512695EAB" modified="2016-09-07" version="1">MKSIEFVVPEEEFDTISSKYSGFRYRNHEKIKYFPEWNPCSKTIRNNDFISCSNASINCLLEENLCHECCQGSYINGTYLLPPGMFPLVCFPGILFFSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI88</accession>
    <name>A0A183HI88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7201</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007354">
        <property type="protein sequence ID" value="VDO49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI88"/>
    <dbReference type="STRING" id="387005.A0A183HI88"/>
    <dbReference type="WBParaSite" id="OFLC_0000719901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000719901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000719901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000719901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19540" checksum="400B3168B075D506" modified="2016-09-07" version="1">LNATKSVVSSSKSKKKNDPLNTFSADLNRELSAKEKEQLQRKADLMLAKDLFGIDDDEPLTYAELNSLDEFRTFGENIGKMLSARSNATHFSEMLISLLKVVVSNMDASKARVLSTVVKTMADEKTAAEKKSKGKGAATKPVIKNISKSNAASTKANKDLYDDYVADEYDDYADHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJL4</accession>
    <name>A0A183HJL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7678</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008178">
        <property type="protein sequence ID" value="VDO52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJL4"/>
    <dbReference type="STRING" id="387005.A0A183HJL4"/>
    <dbReference type="WBParaSite" id="OFLC_0000767501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000767501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000767501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000767501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9666" checksum="309F3FF594EF31A7" modified="2016-09-07" version="1">MISTTSLTLFLLRSSPFTFFIGRDFLFNAPTIKVESSDIVLHWRNGQLRKIAETHQCYDALQYPVIFWYGADGYHFIVKIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK58</accession>
    <name>A0A183HK58_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7870</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008514">
        <property type="protein sequence ID" value="VDO52944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK58"/>
    <dbReference type="STRING" id="387005.A0A183HK58"/>
    <dbReference type="WBParaSite" id="OFLC_0000786901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000786901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000786901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO52944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000786901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9999" checksum="28AC64A8D8D1DAD8" modified="2016-09-07" version="1">MGDDPCECLFNHETAMRRLLSLLRDSQGYCTDSECVQDLPGPQGAGFGANNLMMIVILWALLAIVMFFLRPNSMRSRPDPLGKPGPSSVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKK4</accession>
    <name>A0A183HKK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8016</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008759">
        <property type="protein sequence ID" value="VDO53651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000801501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000801501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000801501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000801501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9854" checksum="863F5C1ADFF07AE0" modified="2016-09-07" version="1">MQLNLRIHGCEHGDHVSAVSNQPNERDRLKVVESCQRATADQRQALFRSAITRLQSPCIQYDDYSLSEHVLTVTEVSPYYEDFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL40</accession>
    <name>A0A183HL40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009092">
        <property type="protein sequence ID" value="VDO54543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL40"/>
    <dbReference type="WBParaSite" id="OFLC_0000820101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5362" checksum="A41528AED1F55F58" modified="2016-09-07" version="1">MASKSKRRKTEKLDETETILLGDDLKEIKNILLDFKVRSILVYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL41</accession>
    <name>A0A183HL41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8203</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009094">
        <property type="protein sequence ID" value="VDO54548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL41"/>
    <dbReference type="STRING" id="387005.A0A183HL41"/>
    <dbReference type="WBParaSite" id="OFLC_0000820201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26282" checksum="BD9B9E73E8381B22" modified="2016-09-07" version="1">MEQSIIRVPLGKTNLLTNVFEANGYEINAELLKLGTLPDEMHIDPHIIAELAGDDNEFENSADDLDDDFVLQANGGELPSLRPPMSFSLHRNEFREKVTNSDDESDEEMKFDSNYDDNQMMEEDVFAAIENKEELRPIDEQFDKLCEEYNETDDEETNEEEEEFLLDPNSDRMKMLAEDFKNKKVELVLVDLFLFIYLFLSATLFSIFFSMSFYSVVIYNCHLAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLX5</accession>
    <name>A0A183HLX5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8487</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009640">
        <property type="protein sequence ID" value="VDO55904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLX5"/>
    <dbReference type="STRING" id="387005.A0A183HLX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000848601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000848601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000848601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO55904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000848601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12718" checksum="06EB7491FCF87C74" modified="2016-09-07" version="1">MPLSCRFYANQFPDVEDTVMVNIRQIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSVNKLIRVGRNECVVVIRVDKEKGYIDLSKRRVYSKDSIQCEERFAKAKAVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMC6</accession>
    <name>A0A183HMC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8641</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009944">
        <property type="protein sequence ID" value="VDO56677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMC6"/>
    <dbReference type="STRING" id="387005.A0A183HMC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000863701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000863701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000863701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000863701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11010" checksum="27F4431877560FAB" modified="2016-09-07" version="1">MICPIILFTKTRCKGVVYGLIGGRDVFTCELYEKTTLNELIYTPNINIYLPKRKSDCKANFDHIQNLAISEPEEKISKRKANYLALLEHPNPFAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMF6</accession>
    <name>A0A183HMF6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8670</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01010003">
        <property type="protein sequence ID" value="VDO56829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMF6"/>
    <dbReference type="STRING" id="387005.A0A183HMF6"/>
    <dbReference type="WBParaSite" id="OFLC_0000866701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000866701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000866701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO56829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000866701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11348" checksum="549FEB0FA99176C2" modified="2016-09-07" version="1">MNDSTRNLRTQSQPIQEIVLNDKLPKNRKSFWRYMGSLTTPPCSEVVTWTIFTEPIVITKSQLALFRNLHDKTGHTMKNFRPVQKLYSRELQLVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMZ3</accession>
    <name>A0A183HMZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010354">
        <property type="protein sequence ID" value="VDO57726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMZ3"/>
    <dbReference type="STRING" id="387005.A0A183HMZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000885401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000885401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000885401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000885401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30886" checksum="8B184B279DD9EC5F" modified="2016-09-07" version="1">MDGFFNGRRLFNAPHNGAVLVSGDRLRNPQNVNILDEDPTFSIYGFPSHLDRYPDDYSLLRHVCSELMQQKKCLFRFRCREHDPINIPVSTPAVQSEGIIVPVTRLESNSNSNNSNISFNRPVIREIPIKIVPATTEGRNHTMRMSRPTSSSSVVGKFPVNDTDEIFMSLDANQSHQSQQKADINTKVSLSEKPLYDNVASGTSFLKDSSRSLSGTRPAKLPVAAETVRLKSNDGGLVEGDRVVWFDAMGIPRRGTARWIGYLRGHTNIYVGVDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMZ4</accession>
    <name>A0A183HMZ4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8856</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01010363">
        <property type="protein sequence ID" value="VDO57757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMZ4"/>
    <dbReference type="STRING" id="387005.A0A183HMZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000885501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000885501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000885501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF27">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO57757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000885501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27272" checksum="5E682187389D1972" modified="2016-09-07" version="1">EDDAPDKNESTEQVYESLESIHVFALAHILKRPIIVVSDTVLRNAVGEELSPIPFGGIYLPLECPSNQCHRSPLVLCYDSAHFSALVTMRHTASNSLQSIIPITDKNRNLLPLHFSVDPGPDFTWWKDSEDAEIAARIELTEADKLSLICEYMDIAKIPIRRYSFRHNLTGIGLVSGGEGKKSMTLSCGDVFVTKDHSTRLLSEIAQQIKKRLKIGRKKKAYFCIMFIHNEEHRGISSYTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPT0</accession>
    <name>A0A183HPT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011687">
        <property type="protein sequence ID" value="VDO61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPT0"/>
    <dbReference type="STRING" id="387005.A0A183HPT0"/>
    <dbReference type="WBParaSite" id="OFLC_0000949101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000949101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000949101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000949101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8163" checksum="032ACFA22FF94FFB" modified="2016-09-07" version="1">MLSSLFSSREEGKKEMRNAFQKIACLEETKISVPGLDFLCVYGDVHRVKILFNKKDNALIQYAEPQQAQLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ10</accession>
    <name>A0A183HQ10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YqbF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9572</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011877">
        <property type="protein sequence ID" value="VDO61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ10"/>
    <dbReference type="WBParaSite" id="OFLC_0000957101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000957101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000957101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000957101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5660" checksum="148721C116E0650A" modified="2016-09-07" version="1">MKEVAVVTYRGYCFDRQGMYKASMMKGQSKMFADRIAEIPEGEDIWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQH1</accession>
    <name>A0A183HQH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012256">
        <property type="protein sequence ID" value="VDO62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQH1"/>
    <dbReference type="STRING" id="387005.A0A183HQH1"/>
    <dbReference type="WBParaSite" id="OFLC_0000973201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000973201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000973201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000973201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8837" checksum="485719A81CC639DD" modified="2016-09-07" version="1">MDMWLRMAWHDPRLAHQLDRPILINDENMLKKIWRPAPFFRNAKESEYHRITTLNFWLYVFPNGEIFFETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRM0</accession>
    <name>A0A183HRM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CTNNB1_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013210">
        <property type="protein sequence ID" value="VDO66108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRM0"/>
    <dbReference type="STRING" id="387005.A0A183HRM0"/>
    <dbReference type="WBParaSite" id="OFLC_0001013101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001013101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001013101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001013101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7387" checksum="C444732E9444FDA9" modified="2016-09-07" version="1">MSSKSELEDVVESVESPESKFDLDEDDEQTPYPSTPSKRQNMDCFHENLNFSNVPEIPLPSVFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRU6</accession>
    <name>A0A183HRU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CASPASE_P10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013353">
        <property type="protein sequence ID" value="VDO66677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRU6"/>
    <dbReference type="WBParaSite" id="OFLC_0001020701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001020701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001020701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO66677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001020701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17677" checksum="000D231864312CF0" modified="2016-09-07" version="1">MHDKKTKAYGFPSTSDDTGDSIEQGEDDVVTIEDLNTEEKALVDQVLVLCSQFIRGINCADVNWYSKLKMAIFLRLQQLVENMKNAVTRRRELRERNEELCRLRQHLIERNRINEPECACEKILPDPTIKEFGPQHQNSFSFIQSEFHAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS42</accession>
    <name>A0A183HS42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10304</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013578">
        <property type="protein sequence ID" value="VDO67443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS42"/>
    <dbReference type="STRING" id="387005.A0A183HS42"/>
    <dbReference type="WBParaSite" id="OFLC_0001030301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001030301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001030301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001030301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18412" checksum="7C673D52B5996B0D" modified="2016-09-07" version="1">MKELVLAVVRKQIDVCLLEKPVTIEKLEELLAAHSYPHMKKIWEKERSAKEAEELQSDAVKSGAKIRKYFNYDKNTSLLFWFFRELREHLRPGIVDLVLKNRKNVLKNGYKFGKLVKSKSMQKGQQFWFWKLDANEKALICTDCSSTESSSNINSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS52</accession>
    <name>A0A183HS52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF_CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10314</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013613">
        <property type="protein sequence ID" value="VDO67536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS52"/>
    <dbReference type="WBParaSite" id="OFLC_0001031301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001031301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001031301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like calcium-binding" evidence="4">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO67536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001031301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="18925" checksum="4FEA496D316571C8" modified="2016-09-07" version="1">MRTVKSICKNLNNLNQFKGEECAETCGKTEWDMDCTRECHCDGGAQCNAETGACPGGKCNPDIDECAEKDDLCPREQPDCVNTPGAYLCICYEYDNTTNTCKGTLPVKIGKSESIAVSIVPVQPVLASTTTSSNLGTTKRSSTTTQSSVQSNSLNDFKTTQSTPLSIKVDFYSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS56</accession>
    <name>A0A183HS56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10316</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013615">
        <property type="protein sequence ID" value="VDO67548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS56"/>
    <dbReference type="STRING" id="387005.A0A183HS56"/>
    <dbReference type="WBParaSite" id="OFLC_0001031701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001031701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001031701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO67548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001031701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11884" checksum="4E197A7538AEE940" modified="2016-09-07" version="1">MNEENHFTVTQVWSSIANIVLIEGRNLTMPNGSENKSPDPFVKFKLGSEKYKSRPAIRSSNPKWLEQFELHMFDEPKHVLEMMVIDRKTNLEIGRFRLFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSH2</accession>
    <name>A0A183HSH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10433</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013895">
        <property type="protein sequence ID" value="VDO68410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSH2"/>
    <dbReference type="STRING" id="387005.A0A183HSH2"/>
    <dbReference type="WBParaSite" id="OFLC_0001043301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO68410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15592" checksum="7EB0FEB01B3CEB10" modified="2016-09-07" version="1">MARQRAAQMERTMRWWSECTASWRQKWSTVRNERNRAREEGHSLRIALTEAKEENKQLLSAKRAVESEISRMKARMHLLQKERIANRMPPEMNSPPETPSIMLDEECQARPEYMHASTITDQPVCITPIALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSI2</accession>
    <name>A0A183HSI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013913">
        <property type="protein sequence ID" value="VDO68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSI2"/>
    <dbReference type="WBParaSite" id="OFLC_0001044301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001044301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001044301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001044301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6777" checksum="CA048DBFEBC19CA4" modified="2016-09-07" version="1">MSMDESVWLIPPHPINMIVMSIFQFDNSTASLLILVCREPELGGQDEKMEIVGQEGGDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSS7</accession>
    <name>A0A183HSS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014163">
        <property type="protein sequence ID" value="VDO69325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSS7"/>
    <dbReference type="WBParaSite" id="OFLC_0001053801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001053801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001053801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001053801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3763" checksum="1339F7169EE2FD88" modified="2016-09-07" version="1">MDPRATEVVDAQVSFGGIFFLQNFNAKSFFIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSU0</accession>
    <name>A0A183HSU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10555</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014187">
        <property type="protein sequence ID" value="VDO69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSU0"/>
    <dbReference type="STRING" id="387005.A0A183HSU0"/>
    <dbReference type="WBParaSite" id="OFLC_0001055101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001055101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001055101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001055101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7646" checksum="F738A9D96AD6BDE5" modified="2016-09-07" version="1">MPNFDPSPSIPDPNDDLVAVAGAAASQSETSSATIAPHFPTTQTSASSSSTLATWQWLRGRIFDSFTFKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT71</accession>
    <name>A0A183HT71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10688</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014518">
        <property type="protein sequence ID" value="VDO70507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT71"/>
    <dbReference type="STRING" id="387005.A0A183HT71"/>
    <dbReference type="WBParaSite" id="OFLC_0001068301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001068301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001068301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="100"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO70507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001068301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21085" checksum="3B8EF5AFC2BD13C8" modified="2016-09-07" version="1">EFDVTVIVPPIIIGKVVEYISAVEDESLELECDFEADPIPDIQWSKDGADVANNVQLLNEKRTALVSSVNSESAGSYRCILINKAGRAEKTFNVRVIMKPELENANVTTLIETLIHRPINLECPLAVTSVANISWSKNSVPLVPDYNDDVQILNAGRQLVISDVQPDDQATYSCVARNNAGEANKNYKLSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT82</accession>
    <name>A0A183HT82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS10692</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014525">
        <property type="protein sequence ID" value="VDO70514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT82"/>
    <dbReference type="STRING" id="387005.A0A183HT82"/>
    <dbReference type="WBParaSite" id="OFLC_0001069401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001069401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001069401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO70514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001069401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17557" checksum="959C1F53E485791B" modified="2016-09-07" version="1">MKNIRRRVYDALNVLMAMNIIEKEKKEIRWVGLPTSSVQECRKLEEEKAKRQERIRHKSDQLQELIIQLVAYKTLVEKNRELERDNGRPREDSVLYLPFIIVNTAKKTFIDCAISHDKFVSSFLCIFCQNMVIVISLWLHATYPKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUQ5</accession>
    <name>A0A183HUQ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarylacetoacetase</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11217</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01015924">
        <property type="protein sequence ID" value="VDO74834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUQ5"/>
    <dbReference type="STRING" id="387005.A0A183HUQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001121701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001121701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001121701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0828">Tyrosine catabolism</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO74834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001121701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14861" checksum="C82B0AAF2664D2F5" modified="2016-09-07" version="1">MRTSDRRSVDVIGRSTVDSAALSDNGSSVRSDEANSEGAGRSESSTPTQRVLAGTAPSPVLPASTRCNLCEVNYESSFDLQVHLHADHIMLRDGKDFCCPKKQCDKVYPSRENLRQHIAAHYHGGATTPLPGFDCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUU1</accession>
    <name>A0A183HUU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016014">
        <property type="protein sequence ID" value="VDO75076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUU1"/>
    <dbReference type="WBParaSite" id="OFLC_0001125301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001125301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001125301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001125301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="5467" checksum="A423C4D3F8A46C9B" modified="2016-09-07" version="1">MSSFLRYHQLQPCPVHYFIRRPRHCNFFIVHHGKMYLLQMDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVW1</accession>
    <name>A0A183HVW1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11621</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017024">
        <property type="protein sequence ID" value="VDO77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVW1"/>
    <dbReference type="STRING" id="387005.A0A183HVW1"/>
    <dbReference type="WBParaSite" id="OFLC_0001162301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001162301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001162301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001162301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6104" checksum="F3093F111D1028B7" modified="2016-09-07" version="1">MAYIEAVKRRVPLINAVLLSYADIPHLGALPYLVRKCGLNCPIYATIKAYNVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW06</accession>
    <name>A0A183HW06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small, acid-soluble spore protein gamma-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11668</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017146">
        <property type="protein sequence ID" value="VDO78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW06"/>
    <dbReference type="WBParaSite" id="OFLC_0001166801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001166801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001166801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001166801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12644" checksum="44B6047399FF61D8" modified="2016-09-07" version="1">MKIQFNGKFSKKQSTNESGKENKVEKSHPNNRQVEERHKEEADSLKQRERKNNYKLPSRHAHYHQKAERDHAVSPDNTLREITGGMPNIELKHFTNNETIYTDDQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWV0</accession>
    <name>A0A183HWV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11955</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017925">
        <property type="protein sequence ID" value="VDO80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWV0"/>
    <dbReference type="WBParaSite" id="OFLC_0001196201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001196201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001196201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001196201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18962" checksum="F616F022BD438075" modified="2016-09-07" version="1">MLCAALLADRYSSSLGYIPCWTTILSSFIESAATDTARIVPIGNHISVFFPTSEAARKAKFMDAIMQTSPGLSFPSEGFVSEKLQNARFQKSCLYLHNVSRISEMQLSTSMIARQLRDMADRFEYHYIEEEQRSTCTPAPLSSHSQVRVLYITFRGTIPYSKIMTHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXL6</accession>
    <name>A0A183HXL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018732">
        <property type="protein sequence ID" value="VDO83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXL6"/>
    <dbReference type="STRING" id="387005.A0A183HXL6"/>
    <dbReference type="WBParaSite" id="OFLC_0001222901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001222901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001222901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001222901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13066" checksum="683EBEA942449556" modified="2016-09-07" version="1">MIIPPDTLTVSHLSHEAFCKHPWIGQSTACLIIADTSHLDDKCWIRLQQYFSNSGKILFLCQNKLLASLSACENLKKTAKLLKMAFGERQSKKLGKDFEYFLKKTLKKLHKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYC2</accession>
    <name>A0A183HYC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12484</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039852">
        <property type="protein sequence ID" value="VDP11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYC2"/>
    <dbReference type="WBParaSite" id="OFLC_0001248501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001248501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001248501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001248501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15337" checksum="843C1A3249E3428F" modified="2016-09-07" version="1">MFFRDQPMKCYQCNSAKDAKCDSSDAKDLKQYIKLCPPLRDGTHAGKKPIACRKIIQNVEELPELIIRECAYTGDKNLDGMRKQGNKAIKLFYYQCENMDKDTPCNGAQQITTRYLTLTLFLVTIIAAALNKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYI8</accession>
    <name>A0A183HYI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039865">
        <property type="protein sequence ID" value="VDP11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYI8"/>
    <dbReference type="WBParaSite" id="OFLC_0001255101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001255101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001255101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001255101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40023" checksum="977FBD684D33D17C" modified="2016-09-07" version="1">MIKNWLKWRKAKKVGAEDETYPVSRKDLQHDPHFISTAAYHTPTRPNVAHRGPLSCPGDLSVNQYDTYGAVLNRALYSDIIIPCEMVHRRRRQQHRFRRVNASTSEYGSGDPSSLTLHNKYNRNLDDSGSDSWTVEYEQTQHIRELEYRVREQRKKLKDYKGRLRAERDLRIVNERNMMEEVEKYKRELKKEQQERKATEKQYIDIIAYMKTKLSLLEQHQPMGQQCLPPSLPFLGDSTINLQNGVSQIRGADELLYSLSVNASSSILPRIDFGQELDETKNFRAEEVWGDLETARNSKNTTTTDTELSDRMRQSITLLKENDSDNDDNGYVTTSEYPAKTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZQ9</accession>
    <name>A0A183HZQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaredoxin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12971</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039996">
        <property type="protein sequence ID" value="VDP12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZQ9"/>
    <dbReference type="STRING" id="387005.A0A183HZQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001297201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001297201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001297201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001297201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34584" checksum="875C0625C1FABC5E" modified="2016-09-07" version="1">MIYSLVHFSAKWSEICEQLNNLLLELKDELKCFDFAAVEAEEVPEVSIANKIVVAPTVLFFKRGKEVDRLQGFDPGELRIKVMKHNFVEGVFSMTKKLIGDEKNNVNDRLKSLVLQSSLMLFMKGTPDNPKCGFSNQIVSLLHGVDADFSSFDVRQGLKEYSHWPTYPQLYLNGEFVGGLDILREELNNPEFCNKLPKLKNKNERLKALINRAPLMLFMKGSPEAPKCKFSRKIIELLAEVNAIYSFFDILKDDEIRQGLKEYSNWPTYPQLYLNGELIGGLDVVAEELKNPDFVKKLPREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZS6</accession>
    <name>A0A183HZS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12988</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040001">
        <property type="protein sequence ID" value="VDP12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZS6"/>
    <dbReference type="WBParaSite" id="OFLC_0001298901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001298901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001298901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001298901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9371" checksum="63F7E40367065FA0" modified="2016-09-07" version="1">MKGEEEWLVSMKKEKVETEERACPKLFTRYLTSPSSEKEENTIPGNHFSLRFVRQKYRVSNVSIRYHFTICFKPLISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I047</accession>
    <name>A0A183I047_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13109</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040049">
        <property type="protein sequence ID" value="VDP12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I047"/>
    <dbReference type="STRING" id="387005.A0A183I047"/>
    <dbReference type="WBParaSite" id="OFLC_0001311001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001311001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001311001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="437"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001311001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="918" mass="101625" checksum="FD0EE240BAC7E884" modified="2016-09-07" version="1">MAADPKTEELFSLLENGKLQSADLAKYDFSTMRNTDSENVLIVAARTGQIDIVQDFVNDFDLEDTDADGWTALLDAAYMGHEEIVQILLNAGAAVDYADMLGWSPLMWAVYKNHYACAELLIEFKAHINLIDEEDSLTPLIVAAGRGYVNFVELLINAGAEINACDKFGSTALIWAARRGYKPIIELLLNAGAELDGVGMYGATALMMATRGNFIGVVRVILSREPNINTVDQNGLSPLAIAAREGYVEIASMLIELGAYVNAIDRFGNSILIGAVRSGNVEIVKMLLEKHADVNARDSENRTALHLAIDKSFMDIVVALLEKKPNLEIRTKDGDTPLLRAVKNRHAGFCQLLVNSGAKVSATDNAGDNVLHVALRARSRKITQYLLLNPSDSRLLYRPNKLGQTPYSIDQENPQPIIPLIYGPLDAEVQVDAMLGYDIYSNVLADIVCEPNLTLPLTIGLYAKWGSGKSVLLDKMKNSMRSFSRSWLDAIQLSWSWSLVFSIALLIAMFTLVGITAVAFLRNFHYIITVGASGLILFISWTLLYSLIYYGNNVKGWNKSISVAHSIAKFLAHMRLLSNVTLQHSASSRDKDVISCPVSFLFADYHRLSSVGGEQALAKIVVTLFESAENHFGSLPVRLFCALRVSFSHGKKPKTRRVCGVPVTAMVSLFLFSINAASVLLALWLYDGMNLQSGYFFGSISFFIIAVMLALYPLYLLFVYGFVSMPKKRINTAAQKISKLHFEGFMQKLQHEVDLLANMIRSLDFFTNSQTRLIVVVDGLDNCEQERMVQTLDALELLFCTRADRPFVVTIAVDPHIIISAVNHSMHSALAGTELTGHDYLKNIINMPFYLHNSAIRQLQTNLRSYMSLREGFEGKSSRKVTVVGTRGLSHSLIADDYFSNMNPRSMKRIVNALTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0M2</accession>
    <name>A0A183I0M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13284</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040124">
        <property type="protein sequence ID" value="VDP13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0M2"/>
    <dbReference type="STRING" id="387005.A0A183I0M2"/>
    <dbReference type="WBParaSite" id="OFLC_0001328501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001328501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001328501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001328501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26375" checksum="2747B87F74A7D882" modified="2016-09-07" version="1">MGRRVDPVQPHLEESGVGDDFINITLTPGGFDKNEGRPVGSDLYVKYRKAGEDEWGTAEPKGDDLNVHIGDLEPGTTYDVIVISKQRDQFGNIRETESTVSHISTTGSAPQSARIWWLIIILLVILLLLIILCIVCLAARQRGAKYPVSEKERQQGRQPILPGIKERGFGEYIKSEDDEKRSLTGSKAESETDSMAEYADADPGRFTEDGSFIGQYVPNKTLVSTINDKPGRDCASTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0T7</accession>
    <name>A0A183I0T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytospin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13349</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040157">
        <property type="protein sequence ID" value="VDP13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0T7"/>
    <dbReference type="STRING" id="387005.A0A183I0T7"/>
    <dbReference type="WBParaSite" id="OFLC_0001335001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001335001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001335001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF69">
        <property type="entry name" value="FI18193P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="241"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001335001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40774" checksum="2F64DBA56828C98A" modified="2016-09-07" version="1">MRSTVVSNDLSRYKFTRDNDLKKTLSHMEEKFTSSCEELQAAEEELVELRVALSDAKRTIEILRVENARQAEKIKFLTIKKQENDQSIKRCDLNPDLEVLQTNQKQMSSVKHGSSKNLQRLVEELKDEKMALNLALKNSKTNESKIVLENNRLKAIIEEERKEWDQMQKDLLVAVKVANDFKIEAQKEMLKLSERITELQKRRQSAAFTVSQGLAVTSYEKNFQSWEDKAWQRLMLDCKRGSRRNTLLRWCQEAVVKFSHIEITNFSSSWADGKALCYLLASFYPDKLSIDKISVLKAEECLELALSVSESMGVEVKVKVADFRKEDRPEWSLIMRYILNLYYIISNGSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I192</accession>
    <name>A0A183I192_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13504</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040233">
        <property type="protein sequence ID" value="VDP13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I192"/>
    <dbReference type="STRING" id="387005.A0A183I192"/>
    <dbReference type="WBParaSite" id="OFLC_0001350501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001350501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001350501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056518">
        <property type="entry name" value="HEAT_Ints3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24566">
        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="95"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="10">
        <location>
            <begin position="655"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001350501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115790" checksum="238DE78D6C0FDA0B" modified="2016-09-07" version="1">MEPSNTRLKRSSKLLNLSAFEQRDELEEKLENGFNMVQNRTSGLPEKESYDVLLQMAGETKATLKLFFIHFFLALPLILNIIVVLQCIVIFQVFESITGGLLYGLLTEPQNAQKYFSIMSLLARDGWFCALCNVNMILFELYPRMRPEVREQIVYFFREAIKSNVPKIDNVLINYLRNANDGSDLKETCILLSAVAGMLNDHHSWLSELKPKASLIPVTLLTFTRFICDLSSFNAFETLRTQMINVCYWLLTERFIDCAQLGRDLILALMRVSKIPQFAAIWKQLLYNPNKLGPNISIEELMNRMCPHTFPLYRISVAMQRKLEFIFAKVKPGTHERHLDWFKKQYLSNPEAGSLRSELVRCAIFLSCGETPQVGQEMKAVFIASMFPQTSSIMEQQWCKLHLLWDWFCYDPATGGHVLIEPAFHVLRHLLHVQPLLANSLVDFMIRMSYELHPQLQQRIIISVTNSFKFLIDHNILGSPSVIFDNPVLQKNVRENFRDTFRGLFRPPQTMQAHLPVAGIEPSEVAISDIEVTPSEISSAITEDVVNIDPSIVEDSGSVDEDFGLSSEEKVMTLLAAVKEEFREPIENLSNVKYSDNDTRCEMMQKLLSSIFDNDELLDEEQIELLSECLLLIFRRDIRNRKPLSEGFLDTPECSSISYLLLFFTSSNRRDQNDTAIAAYIDLCRLLDNPLIQQIVSDLQQCHIDDYVLFAHLIPYIYEKFATEAMGSVELMKLLAHSLDGRQIADLIGEMVRENISFFRKDSFLPIVSASLTWETTAQFVFWQLVHAEGVPVDWILQMISKLQYPKHSEAIAQVYIMLQRMDREPNMGLIRNLLSRTPSDMFTVNCLKLLIKDPDYAARVAELLSSLIDKLIQSGDLLPIHSKGKRPPQRYVCLDQLFSHLDKFRQSCLSKDSHVAEAFLARQTLQEAFTAARAAEKISISVSSLRIRYSELFAVMEILNDDNAQSARSLRRAKTSKKITDVSDVCSLEFLILILFGYFRKITYAFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1N5</accession>
    <name>A0A183I1N5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13646</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01040313">
        <property type="protein sequence ID" value="VDP14290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1N5"/>
    <dbReference type="STRING" id="387005.A0A183I1N5"/>
    <dbReference type="WBParaSite" id="OFLC_0001364801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001364801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001364801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514019" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001364801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53500" checksum="B7B64C4057165ED9" modified="2016-09-07" version="1">MWRAVVLIFLVQAVKAEEIKKLPGTEHLKINFKHYSGFFQVSNIHHLHYWFVESQNDATKDPLIFWFNGGPGCSSLDGLLNEMGPYLISEDGKTLHENPFAWNKRASVVYMESPAGVGYSYSINGNIKTNDDQTAEENYAGIKEFFKTFPQYRNHSVYIMGESYGGIYVPTLTVLVLRGRKQFPINLKGIAIGNGYVSEVLNIDTAVLFAYNHGLVDEKTWNTLEKECCHGCIDVCDLSSVIGGECINKGKIFRFMWSGRLNPYDLYRDCSPNYKLSGSRMRAMQSGLSVTPVDLIKKNKAMIKQKSFESVLDFPKHNNSLTSDAPCMNDSAMIQYMNNPDVRRALHIPQDLPEWDVCSDKITMSYDKVYSDMAPFIKEIIKANVRVLLYYGDTDMACNFMMGQKFSASLNLQRKRRKEPWVLNSQIAGFKTAYDGLTFLTIRGAGHMAPQWRAPQMQYAIHQFINNRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1W7</accession>
    <name>A0A183I1W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Heterogeneous nuclear ribonucleoprotein Q</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">OFLC_LOCUS13729</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040362">
        <property type="protein sequence ID" value="VDP14511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1W7"/>
    <dbReference type="STRING" id="387005.A0A183I1W7"/>
    <dbReference type="WBParaSite" id="OFLC_0001373001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001373001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001373001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21039">
        <property type="entry name" value="NURR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000023">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000027">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="377"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDP14511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001373001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="606" mass="67511" checksum="CA4F882F3AB24F77" modified="2016-09-07" version="1">MKKRGSRGRPRKQQQTATSIMSETDDGEQAAALVAEENANEEGIITTTAQEEEKAGEDNTMTEMKMETSADETLDEEPEIQEEQLQEQEQEQDQEQEEGDDDEEEEATTANGDEMKKEDSDILANVVGASGDGETEDAQALLVEIEEAEFVENEVYKGLRAQSIKPKVAVALIELYEATDMSPQELDDRAIEMLRSLPLEHALFIIKEVRESKLMGVQNKAQFLMSVMRNFRDKVRQLGANVALSQKLVNGPSVEKIKEILDRTGYNLEVTIGQRKYGGPPPDWNGSPAGPQGSGHEIYIGKIPKEVYEDTLITLFEDMGKIWDLRLMMDPLTGRNRGYAFLTYCDKSAAYEAAKKFDGYEIMPGKNLKVNVSVANTRLFIGNIPKSKSKEEILAEFKEHTEGVTDCIIYSSPDAGESRKNRGFCFLDFCDHKTASDAKRKIHAGKLRPWNSDLVVDWAEQQEEPDEETMAKVKVLYVRNLKEAVTEEQLKEMFSAYGEVDRAKKIRDYAFIHFMEREPAIKAMEALNGTELEGIAIDISLAKPQSDKKKMMRGRGRGFGSLRGAFGDFSFGRGVRGGRGTPGFGRVNIGGGFQPRGSAGRSRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I239</accession>
    <name>A0A183I239_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040402">
        <property type="protein sequence ID" value="VDP14694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I239"/>
    <dbReference type="STRING" id="387005.A0A183I239"/>
    <dbReference type="WBParaSite" id="OFLC_0001380201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001380201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001380201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001380201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12396" checksum="667674D0803F2C18" modified="2016-09-07" version="1">MQTEHKSPRSVEIRVPSKREIVLVNETNAPHGTWKLAKIKELNTSADGRIRSVQIELPHGKIRNRPINVLYPLEINQNEISIIPIQDSVEKIEEEEPIASRTRSVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I416</accession>
    <name>A0A183I416_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14478</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040890">
        <property type="protein sequence ID" value="VDP17233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001448601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001448601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001448601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001448601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="26028" checksum="D2B574A3848FCBD5" modified="2016-09-07" version="1">MKRRSVTFTDDPPEVIDNDSDRDRYNMCTPLPTANIFLWLQMARIERRQRKYASETQHKWQEHRYSRSVPDLSKQEHYLSVESKFESESYFNSNNKGRNIFQQKQLIDPIYLSVSDFDMTMRSRPQLRSTIESVRNVTKMDVXXXVRSRPQLRSTIESVRNVTKMDVPWDLHYLCKKERKEKLLQHHHESLSDNFHAKNRNVIIAADTTAESIDKNSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4A0</accession>
    <name>A0A183I4A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14562</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040960">
        <property type="protein sequence ID" value="VDP17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4A0"/>
    <dbReference type="STRING" id="387005.A0A183I4A0"/>
    <dbReference type="WBParaSite" id="OFLC_0001457001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001457001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001457001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001457001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15555" checksum="EE6FF7BC06F35F6A" modified="2016-09-07" version="1">MYALGKTKIFFRTGQVALLERVLHEKLVNSAVMIQKIWKGYISRKKYQHIKESLLRIQLYTRAFLVYRRIKYLQMHRATICIQTAFRRYAAQRRYRLLRAVIIMIQTHYRASVVRQKLEKVFKILINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5K4</accession>
    <name>A0A183I5K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15016</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041488">
        <property type="protein sequence ID" value="VDP20034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5K4"/>
    <dbReference type="WBParaSite" id="OFLC_0001502701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001502701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001502701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001502701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12466" checksum="F8725626101AB433" modified="2016-09-07" version="1">MAQAAVVMKQGLSAMKQVAGQVSQLYAQVVHTMKTNVLLRPMYKWWEGRFWLKEESCYLNRGRARLYTYLLLFLLIRSRSAKNKAEAEALQAKSKEQIIATALRASARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I639</accession>
    <name>A0A183I639_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041754">
        <property type="protein sequence ID" value="VDP20811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I639"/>
    <dbReference type="WBParaSite" id="OFLC_0001521201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001521201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001521201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552784" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001521201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5684" checksum="E8386A25C4A60781" modified="2016-09-07" version="1">MNVLILLIITSIVPKMLDVKIQQEVLRVFVIRDSRISVLIILFYLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6H8</accession>
    <name>A0A183I6H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15341</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041984">
        <property type="protein sequence ID" value="VDP21419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6H8"/>
    <dbReference type="STRING" id="387005.A0A183I6H8"/>
    <dbReference type="WBParaSite" id="OFLC_0001535101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001535101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001535101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054518">
        <property type="entry name" value="ABHD16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF72">
        <property type="entry name" value="BAT5L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22990">
        <property type="entry name" value="ABHD16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylserine Lipase ABHD16 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP21419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001535101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35846" checksum="B6CE96AAAF9ED0A0" modified="2016-09-07" version="1">MLVKFTVTYYVIAISMRTAGRIFNPEYRRFAETLFEAHLNDRNAKALLREYDYELFAAPIDFQARRQSQKYFKTPSRFTNARNMLYTTLRDCLSYNIVYTFARVLVYPGSAALLNRLIQSFLIENRQKLVMEKGAIRGVLMTCEGNQVDTMFVDRREQGENGGILVITCEGNAGFYETGIMPTPLALNYSVLGWNQPGFGESSGLPTPKQTVASIDVVIQYAIHKLGFAENQIVIYAWSIGGFPATWAAANYSNIRALILDATFDDLLPLAEAKMPKSWAPLVEFIIRTYFDMPIALQVQHIFRKKMRNRIITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7M3</accession>
    <name>A0A183I7M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15734</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042735">
        <property type="protein sequence ID" value="VDP23529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7M3"/>
    <dbReference type="STRING" id="387005.A0A183I7M3"/>
    <dbReference type="WBParaSite" id="OFLC_0001574801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001574801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001574801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001574801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27661" checksum="EC3A12A4A543AC11" modified="2016-09-07" version="1">MRRKSIHHKISHVSHSSLFSLKRQTRITLSNSVSDDRSVAEAISAVLAVTFDRRSRFENVNRVAVVEKAMKVLGRKSSTKAFVDKERDLQHWRSEESERVDLVDDLAFLCFLYSDVCDEATITICMIEAARSRAAAAAAAISTSDDACKKINRVEDDGRLILNIRLNVDPLRLHEYSKNLILCEIDVFALQFQLIDKHLLECRRVQKLQPSRATTVIRLRKCILQQSLKHIWKLLFGCFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U5E9</accession>
    <name>A0A3P7U5E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000771">
        <property type="protein sequence ID" value="VDO30040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="131" mass="14721" checksum="C53BA6334153FB7C" modified="2026-01-28" version="1">MAVKDRSLEYGMSKITICYSTPALSTNIKVKRYIPAQWPLASNDAAFDDLGNFSCQRWKKGGATLNRNNQCPFTHSTDLPQKSILIVCHSVSECSLLARKYCYWRESSACNVVECGDSWPPSDDSVWINFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VHX9</accession>
    <name>A0A3P7VHX9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006515">
        <property type="protein sequence ID" value="VDO47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VHX9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="244" mass="28281" checksum="E28FAE216B85F762" modified="2019-02-13" version="1" fragment="single">MASVGLTCKKEDSSTDEDDDDDLETGIPGLQRQPPFHIVDIHYDFQIPHRFIQKNRRIYPHTNEDKDDTNDFIIADAENGLESLDSTSKDFDFRYIEKRDKWLLAMNALKTFADDKDMPKYYNQRFRLFSKLNEGILMDREGWYSVTPERIAAHIADRVVIMKDTVVLDGFAGVGGNCIQFALKGAYVIALDMDPVRLRCAKRNAEIYGVADRINFICIDFFNFCKFHCEKVRQLKMGVRENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VUL4</accession>
    <name>A0A3P7VUL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008090">
        <property type="protein sequence ID" value="VDO51951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="75" mass="8573" checksum="AD8309C6073B85BC" modified="2026-01-28" version="1">MNSRESEQCKCHLSTEQEKMGKAEAILTWNLKKSIFTGTLEIENEHRDASNMGIFANIDCETNSQVVVQIRNQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W6P8</accession>
    <name>A0A3P7W6P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004351">
        <property type="protein sequence ID" value="VDO42377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W6P8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="303" mass="32382" checksum="17087DAFE0243DF8" modified="2019-02-13" version="1">MQIHLSFSQGGSSGGKQLKDKALKPKETIQVPPIQSEFINVFLKSIGVTVTEIQDVVFKLAFFEREYAFYTASQLQSEITGHYTSQIVKQLYVLVLGLDILGNPFGLVRDLSAGVQDFFYQPFQGAVQGPEEFAEGVALGVKGLVGATVGGGVGAVSRIAGTLGKGVAALTLDEEYQRKRQQMMNRRPKTIGEGVARGVKSVGQGFYEGITGVVFKPLTGARTGGAGGFAKGLSLGLVGVFTRPLSGAVDFASSTLDAVRTATVGIDEMKPLRPSRVIFSDNIVRPYCQKVAIGAQVFRVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WZB1</accession>
    <name>A0A3P7WZB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013346">
        <property type="protein sequence ID" value="VDO66650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WZB1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="180" mass="19835" checksum="B36B16B506FFD17B" modified="2019-02-13" version="1">MTVKQFYFKVKPGSSKADELKAVDKNISRDEKDLSDVAKLNEKNDAKQSDAEQTQTDTVTTITTKTKYNGESEGEFTEESHIKIIHEEKSSISVVTESNADMEHNGEMNDSPVRDKPVTVVSGADGECSNEPETTSNAEAINTTTEEIGKIKSNEKLPKNESEEQKNISGVQEVESAMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X5R8</accession>
    <name>A0A3P7X5R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000098">
        <property type="protein sequence ID" value="VDO25398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYL4"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF40">
        <property type="entry name" value="SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="828" mass="92312" checksum="B4C56FFCD85E4609" modified="2026-01-28" version="1">MVKQNDGEILGPLEIDVSEMVATTYGCDPKKSQRESAESLRHRMALSDGAMYNSSGVVLRPTTTSRSYSSVGVSSSATCPIQLSRKSKGKPENICQLMASADQRMSNESKRTSYETKSGKTLLKGRSVSVTTLGDLHTSGKTIAATAMSLKKFASQLRSPRFFEPVTNLKCSVPYTPPPMLSPMRRGSGLFWKISQTPPSKISMLQSSQGDNFDELGASESHRENETNEEPIGKRLRRCITSTLQPVKETSVDEDQQGMRTPIRKNGLCYSSQFFDTRLLRLEALRKESDISWNSSNSSSIPPGATDLPSPRKLSVSLDGEAVRKISSCSDFGEEIYIAPESDAVPHINCGRDYQVKVKKWADRAITDEERDAIPDRDDAIFDCNVIDHLDDSAVEAYELLAYSKAVPRPGRNRELALHLLMENKGNIQEAVLDLMRSDTLDWSQYPIIYNSIYTDTSSWTPEEISFFQDAIYKGEKDFHQVASDLGNKTVKQCVEFYYMWKKACPDDYRKLRNLRRKRQLLEMQQQLDLMESYNLRSNSRPAENDELSDSEEGSDLSAISHDTRKMKSGNLDRNIGCSSVVRKYSVPRFGELPHSSASSSLVMGNGSAPRSFGQLHRTPVKKGAQPAADGFFHCRLCDKYFEKVKSLNAHMKSHAMKARAEAEAAQSQLDLQHHDSNIKTTNVINIHEKTISAKNSPMTDSMSFVHHHHHQKEQQQNSLNTDPLKASIERPIMQVTNNFAASSTAAAVASEQHPFGGRRLGQDLFMQTGLTPEHHHFTQNTLMSGSLGLAAHQALNQSLTAASVLNQFPQTQALQFLNNLQNPAITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XM54</accession>
    <name>A0A3P7XM54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009151">
        <property type="protein sequence ID" value="VDO54703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XM54"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="112" mass="12319" checksum="3A95EC11F615895C" modified="2019-02-13" version="1">MQFHKTPKNLTGIDNILVDNYNVSLSPFTEVFRLVNNSVQNLQRLSCTLDGMVDGENTNQNNLMDEANKLLKMCANIHQKIMDVESTSKIGSSANSDTKAASSEGKCPIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YHI5</accession>
    <name>A0A3P7YHI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002323">
        <property type="protein sequence ID" value="VDO36605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H7K8"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF76">
        <property type="entry name" value="ADRENODOXIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="142" mass="15676" checksum="B680520FC11DDE09" modified="2026-01-28" version="1">MMTVLRYCIRLAVCPQSILWRGLTAGVPDVKIRFKNRGETLEAMGKIGQSLYDVVVDADLPIDGYGACEGTLACCTCHVILEPNHYKRLPSPVEDELDLLDLAPEATDFSRLGCQVKLTEEDLPSIEVIVPSEVRDARVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C2X0</accession>
    <name>A0A3P8C2X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040631">
        <property type="protein sequence ID" value="VDP15718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796838at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="90" mass="10214" checksum="7EEDBA34990AF085" modified="2026-01-28" version="1">MRLSALQLCEKTTQAIRKVSRKNLLRICGTIVIAEIVLAVYAEEFALPTPDMVYDFHMKFSREFADFAMGNKYGAGAFHRVGDKQRSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EQG0</accession>
    <name>A0A3P8EQG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039847">
        <property type="protein sequence ID" value="VDP11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY95"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="683" mass="78555" checksum="C59D3E1B7851B57B" modified="2026-01-28" version="1">MGARISSETAIEENAYLRRFVGLQPISDNDPFWNHFLSFNFLIDSNDRKKAEQFDISLLDSLQSLMYNTSTTSNFASFIHVFLRRAAELKASEICNSTIFLWQTENALIILRYICKFFVERLSEAEFIKIFGMTKTYFEKKEAYDSDFEDEFDDSCENKAEEFLNTLVDILIDLPLNDSTETIHIEAVKCLIALLSSQLYSDDVTKSNIFYGYLMQGKCSTRSLEFTRALISNYLQRNTPCIIKYEKEPESIVLGLAASVWSAVQIVTGMNDSNSVTNDGEIVPPVSLGSLSVLLLLNLACHQEPGAKLNPYKESLSKFQNSQEVSSLNNETGTFKLDYSLLYERLCATVNQQSPMLFLYILLHRNVGFRNYVLSRINLEKLVLPVLIVLNNEAQSSGMINSYNAHHIYLALIIILILSEDDFFCKVAHETMIKNTTWFSNERTLGEVSLGGLIILVFVRIIQLNTLKTKDSYLHTNCLAALANMSSYFKNLTSFVCQKLIGLLEVFIRRHAKLIENMRVRAEYDIVQEKESHNYHKDITALEEGIRTLLEICNSCLTSNLRSNPHFIYTILYKRDLFDAFQNHPMFQDLIWNICAVINHFASRVQLLEKESSVSAVLAAIEKGALHWPTDRLKKFPELKFKYVEDDNTVEFFVPYIWRLTFQFSTLYWDATRIRLFNSSFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYD0</accession>
    <name>A0A183GYD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein CASP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS240</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000068">
        <property type="protein sequence ID" value="VDO25098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYD0"/>
    <dbReference type="STRING" id="387005.A0A183GYD0"/>
    <dbReference type="WBParaSite" id="OFLC_0000023901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000023901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000023901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000023901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11483" checksum="A67112DA30515176" modified="2016-09-07" version="1">MKPLVRNEKLHIKALNLKISSLEAEKTVLMTRNNELESRLIHLDKNISAASPIAPSTAVVTSGAMEASSNLGKITERQTSTEALQWSMPENVATVQGNFVLQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYM3</accession>
    <name>A0A183GYM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS333</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000102">
        <property type="protein sequence ID" value="VDO25442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000033201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000033201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000033201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000033201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30778" checksum="E34F20B8AC1008CD" modified="2016-09-07" version="1">MTINKELFLIITFAVYIFQGILLIICNGIVELVLIRHRHLRRQYIILLAQNFVDTLLGFGFCIAGIGRLIIITSGYFQISRPYCLLLPWSIIIIWQVLMSSDVLQPFFANLYTTIMIVSASLGVILYILVYLLSRKHLRRIKNIQTEISLRLFEARQRKLTITMGVSCVFTLIFYVLPTCLKLLIPDEDDDPMTYYFQLLRVAIAISCNLNPLTNIAAILIKQDDIACRVKQLFSECSQKFCKCDQVMTCTRRSRSLSTLTANPRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ41</accession>
    <name>A0A183GZ41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS501</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000170">
        <property type="protein sequence ID" value="VDO26020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZ41"/>
    <dbReference type="WBParaSite" id="OFLC_0000050001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000050001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000050001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="12">
        <location>
            <begin position="42"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="13">
        <location>
            <begin position="951"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="14">
        <location>
            <begin position="1471"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="504"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO26020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000050001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1689" mass="195831" checksum="E2BB4CDAB1D5C247" modified="2016-09-07" version="1">MIIFSNFNHNLENFREKRSIHDEINYWKARKDNAALQYSEAFQILDMKLEILKNCRIDEICEVIDTIEDCLNQLWSCEPSFPQNRMEQIMDSFGLLIVNSIANKIEINNIWDSDTTDTLIDSLHTVISLCEQWKFAITTLTEQWKQDIANPWKGDKPMISTFEILQKHTDKILSLKLLSYQINELMGDKNERKEIEQIIRNIFGTLPIFTCDISVQKQWKIKLLEAERSIEPIVERALPVLRKRLQFNKLTDDAAITNLIKFKHFLNRSTIKEKLSMERETLLSHLANAVEAQKREITDRISTNDIPAGQYLTEIAAKLIWIRREINKVGNIKIVCDELLNDLATYKMIEAKIQNTINEMHSLESDSFSVWCQEMIKTVGNSTSSIALEISGKLMSIEQKGGNLIVNYSDRLVRLLREVRQLIGLGFVVPRKIIECANTGEKFYKYAIILKQVAHFYNSVDQQMLPCQQSMMLDEALAFEKLILSGKKSKTTTNMVSWNNPKHLQEFIEKLQAAAERLTLHNRRLRKAHNEICDKIKQLMKLDLLKEINKWKDILGEIRSKIAEEERNIGNRNNMISWLSHWDRQLYKTLQLQYQWGIESLHMQIPLIQVQLVFKEQQLEIRPPLEEIRAKYYRELRKFISIPQKFRGLQETEQTNGLFAKMIECNANRFRSVYEKAEQLFEKLVSVGNEFENWVVLGQVDLESLITKHFKQAADWENQIKLLKGKGRDAEKLPSEVRLECILVSTSAVKNAIDDMLQRVFDTLIWTLRYSISNEIHDMNRFLNQAIEVLSSRPKSVEEIAEANQKHIEFGKSNKEMKRMLDLIEEKNVLLRSIGGSGSEQLPIVLELWENFELMLDTHQLMIKEQVETLKSNVATRLKSLSDEIEKLFIRWQQFKPKNDILSDDRNAMLGAIQFIKEKRDEFDNLQQKRDILLTECEQFDIEKSEMPLFDEMANDLKNCENNWLFYEQFNVGLQEMADEEWILFRSKTYRFDEYLHEWDDKLKNLPVTHINIRLRKDIDQFKAMSTGLKYCRGEILSNDHWLMLFRILGMPKGTTLERLRFGDFLNVHKMIGENLEALKNLNERAQGEVTIREAIQELELWAQQAEFVLTDYKISNGTVVKIIKDWKDALNSVKDSEALLQSLKNSSYYAQFTDKTSIWETRLADTEQNLQWMNEIQRKWIYLEPIFGRGSLPSEASRFNRVDAEFRVVLNDVIQDPRIVSLSTRASLKRTLEQIIDQLNRCQKALNQFLEGKRNAFPRFYFLGDDDLLEMLGQLMNATVIQAHLKKLFLGIHKVVFGNNGETIIAMVSSDDEILQLSKPVKIVPQAEDWLQELSNEMKNTIRKLITICVAETSPDPGKYPSQVLCLAEQIRFCERCERILSSKCDLQSYRNQLKQTLANYTNSRTSDQVLKLKLKALIMDVIHNISIVDELIDNSPCSKSSWVWQKQLRFYLDPKEHVVIRHIGARFDYTYEYQGNAPKLVHTPLTDKCYLTLTQAMSMGLGGNPYGPAGTGKTESVKALANLFGRQVLVFNCDEGIDVYSMSRIFIGLVQCGAWGCFDEFNRLDQTVLSAVSMQIQVIQDAIKSRSGNCILAGRNVPVDLNSAIFITLNPVSKGYGGRQKLPDNLTQLFRPIIMSVPDNELIAETLLSAEGFCDAKKLSRKLVSIFNLSKLACIFVLFFNSLTYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZK1</accession>
    <name>A0A183GZK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OBERON-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000240">
        <property type="protein sequence ID" value="VDO26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZK1"/>
    <dbReference type="WBParaSite" id="OFLC_0000066001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000066001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000066001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000066001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29364" checksum="646EC1906C5A2A59" modified="2016-09-07" version="1">MSGEAGHFFGSTIKRSYELLYRIIFVRKSNKCKQFISKIDAIIRVFRRDDSTKELAEMRPRFEGLQGELRQRVEEGRKMMAQLRSYEEKERIWKKEKADLEKRIEIKDAMAAAERKNNDEWKKRHLTEKAELERKVKLAEPEIRRALDAETIKDAIEDIRAFYEQKLELTLNELNTFKMKHSKSAAVSSSSSSALKLEIYRPMSAPPVCCAPSSNAHLSNGRPSVSADFIIKTHSSPSNSLTDNDTIDNDDSSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H022</accession>
    <name>A0A183H022_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS832</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000332">
        <property type="protein sequence ID" value="VDO27256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H022"/>
    <dbReference type="WBParaSite" id="OFLC_0000083101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000083101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000083101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000083101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6539" checksum="C2A1D3E4B4207B77" modified="2016-09-07" version="1">MIYGKEEIGSYQIIVATALITEIIHLFKFFRSFYLEKLHLYGPIVISVCDLFRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0U1</accession>
    <name>A0A183H0U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/LRR-repeat protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000472">
        <property type="protein sequence ID" value="VDO28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0U1"/>
    <dbReference type="STRING" id="387005.A0A183H0U1"/>
    <dbReference type="WBParaSite" id="OFLC_0000110001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000110001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000110001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF246">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000110001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58607" checksum="3F3BC68F3B5DE7B5" modified="2016-09-07" version="1">MVKSLFNICLAAACQHNLYRYLADLPTSCKQRLLEFFSSHDQLFLSECAQLVSSPSFGGNLTELRFYLSEQVTDTVLEAIAAHNRALQQIAIIFCQNITDNYSGIPFQGIKAITSGQRKLEKLEFRALKKLTSNGLSLIKSNFLHTVDLSSCTKIKSDGIYQLVHLNRNIHCLYLNNCRSLTDQALYDIAHYLGEKLSVLELDFLPNVIDPSSALFYLSLNCPNIKQLSLCRFFEVESELALMPEYRIAGVGLRDVDLHGNYFSTLPLLPPTVSRIRLSVCGDEDVNSLINRLETLPQLTSIHLQMNCKEPSWRCIEDANTFLRTILPYIGSKITRLHISLPTIIDGVFSLITQCLPNLSHLALDVKHINNKLLRLFFAGGAHSAGSRLRSLKLCRLRTTYRALFAIARGAHSITDLEVSHISCVDDRFLALLADNCMGLKNINLNGCRYVTDEGLAALARKCCLKEVRIRATSCTDKSIYLLAQFCPDLEWISHADFSGRPKFSDKALQCLKDSCVQRVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V8</accession>
    <name>A0A183H0V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1120</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000482">
        <property type="protein sequence ID" value="VDO28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V8"/>
    <dbReference type="STRING" id="387005.A0A183H0V8"/>
    <dbReference type="WBParaSite" id="OFLC_0000111701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09195">
        <property type="entry name" value="PLDc_mTdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="68428" checksum="24B76FDF0792392E" modified="2016-09-07" version="1">MKRCVNETSTCGGQESDDLWSEEKRVRQNCLTDRLYFNKVIDVAEQYNANAFSFSELLELISPVASIHFNFMIDLSWLLSQYPGRLRQGPITLIVGERMGTDFTMIKTAVKRCAVKNVNVGRARLVIPFGTHHSKISIFESSTGRVHIIIATANLVEDDWKFKTQAFYHCSGNELAASDSSNRNGSDFQTDLVKYLNEYKTSQDWGLIEHWRDRIANIDLSHVKARVVYSVPGAHKGIKLTKYGHPRLRVILKELFGNVKMDDFTYHAQFSSFGSLGAAPQYWLTGQFLNSLSGGAETDDGHLRIIYPCVEDVRNSNEGYQAGGSLPYNNSVAIKQPYLLNFMHKWRSDHLGRSRAMPHIKTYAAFAKNSLKPSWLLVTSANLSKAAWGDYQLKKTQLTIRSYEFGLLFIDSESLDMLPYDLPLTKYDDNDRVWIVDKTYRKPDIFKKTWPNRFKSCSMAKSGKCVLSFGDTVLYEADLRALENGRWLSDPVISFAFEYLHERTLDDTRKSKISFINAAVCQLIKLTSEIEVVELLDQLTLKEKEHVIFVVNDHDDPSRSGGSHWSLLICRRVLRPHFLIIDSAQGTSSANRKPTDKVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1X8</accession>
    <name>A0A183H1X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000710">
        <property type="protein sequence ID" value="VDO29728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1X8"/>
    <dbReference type="STRING" id="387005.A0A183H1X8"/>
    <dbReference type="WBParaSite" id="OFLC_0000148701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000148701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000148701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000148701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32724" checksum="D81457DA153AEA74" modified="2016-09-07" version="1">MILHQRQMALLRFQQQEQEMQMKRMQMIGQNVQMNPAGQPTEMQYGQMITEPNQPNMQGNGIPCGYPTGAYAEQAQLNYVMPMTVTTQSYPSDAHIMQDSTAAAAVKQDSNIANYTPIQPYADQISLDVQRLQEQQHFFKSDVSTSNYQLNVAQNSTLLATSNTPAYSIASLQSSISRAYPGYQQPAEQSPATIPGGHQQQQQLQATAANIGHQKFGPQEQQKPSLVPPVTLPAALSQHTNRMTQPFSPYPLSNGMIMEHPNQSMRYSVDFQANVEQQSQIAAQPTEELLISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2N2</accession>
    <name>A0A183H2N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1742</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000878">
        <property type="protein sequence ID" value="VDO30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2N2"/>
    <dbReference type="STRING" id="387005.A0A183H2N2"/>
    <dbReference type="WBParaSite" id="OFLC_0000174101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000174101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000174101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000174101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1181" mass="137034" checksum="022AAB358A1355F2" modified="2016-09-07" version="1">MNRLPRSVTTVEWENSFVSVYSKDNPNLLFDMCGFECRILPKCRMATEELTHRDGVWNLQNEVTKERTAQCFLKVDEESLLKFHNRIRQILMSSGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPARFPPVVFYTPKEIGGLGMLSMGHVLIPQSDLRWMKQTDQGGITHFRSGMTHDEDQLIPNLYRYIQPWEAEFIDSQRVWAEYALKRQEANAQNRRLTLEDLDDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTEFKTYQILKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFRGTYFPTWEGLFWERASGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELDALEIQTVQKETIHPRKSYKMNSSCADILLFAQYKWHVSRPSLLADTKDVMDNTTTQKYWLDIQLRWGDYDSHDVERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLYSAYGNWFPGMKPLIRQAMAKIIKANPAFYVLRERIRKGLQLYSSEPTEPYLTSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLSQLAKWKTAEEVAALIRSLPVEEQPRQIIVTRKAMLDPLEVHLLDFPNIVIKGSELMLPFQAIMKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRVILIMRGMHINPDKTKVILKPDKTTVTEPHHIWPSLSDEDWIKVELALKDMILADYGKKNNVNVASLTQSEVRDIILGMEISAPSAQRQQIADIEKQTKEQSQVTATTTRTVNKHGDEIISATTSNYESQTFASRTEWRIRAISATNLHLRTQHIYVNSDDVKDTGYTYILPKNVLKKFIIIADLRTQVAGYLYGISPPDNPQVKEIRCIVLPPQWGTHQLVHLPNQLPTHEFIKDLEPLGWMHTQPNELPQLSPQDVTSHAKILLENESWDGEKTVIITCSFTPGSVSLTAYKLTPSGFEWARNNTDKQSNNPKGYLPSHYEKVQMLLSDRFLGYFMVPSSGIWNYNFMGVRHEANMRYDLMLTNPKEFYHEDHRPLHFQNFKGFDDPLGVAAADREDIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2V7</accession>
    <name>A0A183H2V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1817</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000929">
        <property type="protein sequence ID" value="VDO30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2V7"/>
    <dbReference type="STRING" id="387005.A0A183H2V7"/>
    <dbReference type="WBParaSite" id="OFLC_0000181601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000181601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000181601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000080">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF9">
        <property type="entry name" value="UNCOORDINATED 115A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO30883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000181601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14833" checksum="C0B423FE6F48958F" modified="2016-09-07" version="1">MTHDGKPLCIRDYNTKYGVRCYECDKYIAGKVLQAGGYKFHPTCARCSRCGERFGDGQEMYMQGDEIWHPGCEHAKVTENIAVSHFDMFCTYVTELSHFPVRVLWFRLILSNVQTWHRFSSWFCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H392</accession>
    <name>A0A183H392_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1952</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001038">
        <property type="protein sequence ID" value="VDO31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H392"/>
    <dbReference type="STRING" id="387005.A0A183H392"/>
    <dbReference type="WBParaSite" id="OFLC_0000195101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000195101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000195101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049400">
        <property type="entry name" value="DYNC2H1_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF352">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21264">
        <property type="entry name" value="DYNC2H1_AAA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="5">
        <location>
            <begin position="378"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="3">
        <location>
            <begin position="539"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="2">
        <location>
            <begin position="790"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000195101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="930" mass="106235" checksum="C77CA66A1E0EB35E" modified="2016-09-07" version="1">MPSGERIQFGSNVNFIFETDNLSNASPATISRMGMILVSEQDMDIQELISNWLKEYNDIHPDMSDWIRNHLYRCLDWIWTKGIIEINVSKTATVKNALGHARDVTSNEEFLVALYRGLAPNLNSKFRNQFAAEVVFNEISLPDKQHPGNVYYDKRANSLLAYTDDMVIPNNTDQLLSMERLSYILTANAQANRDIICSWLDNRNRQPFIIHGPNGSGKESLLRYCVELDPNNQLAILHCSAQTGSQQVLDLLHQYCVQISSASGRVLKPKEKQILIFYIKGINIVKPDKWGTCEIIAFLQQLLTYEGYYNEKLEWISLENIQLVLSITLANDEGHYLLPSRFVSLLRICKVEYPTQEELITIYSSYLTFLIKFKIFQDSVESLRHRLNDLASIMVHLFNDVRNAFKPTDKSHYVFSLKDLSNWIFALTRYDISGVNAGEKFLCSMLYECRRIFKDRLVNNEHKQRFEDIISKNLSSAAVHNDENNLYVSAQGALSMTMLKGMPLSLVPHKEYAKLLQQAVNRYGKFYLTFHIANFKMPIFDEFVKLCSQIDRVITAPGGSLLLAGRAGMGRREAASLVANIHQMPVFSPKLTSSYGIKQFRNDLKMVIQDVAINGKHVVYIVEDYQLLHDTFLQSINSLLSSGDLPGIFTIQEFDSFLVSLREQASQDAFQGDLYSYFVMKVKANLHIILILNIDDANFSLKCSSNPSLYKECSIIWNETWNKDALSQLSELILSQHHIKATNDILIAFGQIYHHCPSEIAPPAKYIRFIENYVYILNKKRTAIEIRSNRLKAGIGKLTEARESVSQMQKKAAKKSKLLAEKQTDADAALKAISQSMTNANYQRSDMEQLKLATIKENERIEKQKSLIEEQLRVVEPILREAREAVGSIKSESLSEIRSLRAPPEAIRDILHAVLLFMGIFDTSWEAMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3K0</accession>
    <name>A0A183H3K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001110">
        <property type="protein sequence ID" value="VDO31736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3K0"/>
    <dbReference type="STRING" id="387005.A0A183H3K0"/>
    <dbReference type="WBParaSite" id="OFLC_0000205901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000205901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000205901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22840">
        <property type="entry name" value="Gal_Rha_Lectin_LAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF456">
        <property type="entry name" value="FI01427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="2">
        <location>
            <begin position="218"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000205901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37474" checksum="151196AF84210306" modified="2016-09-07" version="1">MMTAKLSLVAGDPPIHCQSKNKTDICLNNGTCLLTSKSAAYPLCHKQESYFNGSCYKVVKSRKTWYEANQICEAYGGSLVAIENEFQQLFVSDYLLSSLKADILAHNITVWTAGHVVLNGSEQVYVWTRNNYANEIDFWQNGQSQMTGDCIEIDSQSMFREWILANCSDSNYFFCRRPTEMDELENVQCMCYNGYRGRFCDQSSINEFGITLESQCIVCADNEFEFSCPNGSSIYVDFAAYGNIGTSNQLCLISTPLEVNVTVWEECVHPSSLQTMISMCQGHSHCQITNFQSLFPENPCLPTTPITLQYRMRCLFSLFIISVITENLIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H409</accession>
    <name>A0A183H409_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2219</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001230">
        <property type="protein sequence ID" value="VDO32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H409"/>
    <dbReference type="STRING" id="387005.A0A183H409"/>
    <dbReference type="WBParaSite" id="OFLC_0000221801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000221801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000221801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="159"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="14">
        <location>
            <begin position="343"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000221801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50600" checksum="26E70E5E1D036526" modified="2016-09-07" version="1">MRLKSAYLLRLSKRNFTFSLTTRTSKPQSASPQIFELDGILLSPDEKWNLSPAVLRTLQRRLLFEVDNPLCLLKQRIVDFIYGKFQVKGGMSPQFAVIDNQPRVVSVFDNFDSLLVPANHVSRSVQNTYYINKDYCLRAHTSAHQHSLISQGLDNFLVIGDVYRRDAIDNLHFPCFHQIEGVRLFTAAELFNDSLNRYPKPLFANDKRTAEKQEQHTKDVAECLIKDLKATLETLCQHIFGTDYDMRWVSADFPFTYPSYELEIYYEDKWIEILGCGIMEQNLLKMAGIVDKVGWAFGLGLERLAMALYGISDIRLFWSRDSGFLTQFSGKSPDENFKYVPISIHPQVLYDLSFWLPEGVGPKEMAAETCDLIRSIGDQLIEQVKITDTFVHPETKKTSQTYRLVYRSHEEALTKEEVNQIHLKIRRKLVENYGVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4A3</accession>
    <name>A0A183H4A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001301">
        <property type="protein sequence ID" value="VDO32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4A3"/>
    <dbReference type="WBParaSite" id="OFLC_0000231201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000231201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000231201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF49">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000231201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36493" checksum="B6C4B176F4DE0CF3" modified="2016-09-07" version="1">MRFFHSENLETPFCPFDANPLILMSGEYITCKPAIAKECPSGFVCDFSVVLGQSICCQDMRNQPMLNIKIKIPSTTNATSTPSSTVLPTRSNKMKTQHHFWLSTIPNRQSPWYIKDRKPLYKTGWNETTQNLLPSRTITTTSATVMSKSHELPPTTESTIDVDNTEISVEEHSNTTNKITTINKQQEIPCHNRSEHGVISTKISQTVLPDDYATSVSFIQVGNIKRLTDSQTLIVGAITLINDHGYRILVDTGSAADTELLLQGLSKEMITMDDIAVVVVTSGHPSYTGNLNLFPMKPTLFHTMEYLEQQATITDLKDVCVVLSFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4G9</accession>
    <name>A0A183H4G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dirigent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001358">
        <property type="protein sequence ID" value="VDO32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4G9"/>
    <dbReference type="WBParaSite" id="OFLC_0000237801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000237801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000237801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000237801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8578" checksum="2D5CFE1227C8F958" modified="2016-09-07" version="1">MGIGEVEDVGTVLQDMNIGGMALFRSTGWGMTQALLTPTGASLQINILVNSISEMSIVRYEFVNFSTILKWTAFFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4R8</accession>
    <name>A0A183H4R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001433">
        <property type="protein sequence ID" value="VDO33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4R8"/>
    <dbReference type="WBParaSite" id="OFLC_0000247701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000247701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000247701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000247701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22578" checksum="1B49039BD007DA42" modified="2016-09-07" version="1">MDNYQVAYLSKEAIIANYSMFANTIALGHIKTIDLLASNIACRRHFYGYGESYNFGNDQQLSCAICHSKVLKKFLEFHAWMHLSWVFQVGDRFPFQCTRCEFAAYRIPDVVCHTKEIHGNVDANLFVPTVPLGILQFYFNKVTECFPPMKYSLKLQICFENPQSSVSSNPFPKIWIKKCKRSDEKDIPSIIGYTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6J7</accession>
    <name>A0A183H6J7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPRY domain-containing SOCS box protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3108</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001978">
        <property type="protein sequence ID" value="VDO35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6J7"/>
    <dbReference type="STRING" id="387005.A0A183H6J7"/>
    <dbReference type="WBParaSite" id="OFLC_0000310801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000310801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000310801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="3">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000310801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20955" checksum="ED3BBBF4DB73C66D" modified="2016-09-07" version="1">IGFSKGFHVWQIQWPQRQRGTHASVGVATKAASLHAVGYTSLIGSNSESYGWDLIRNKCYHDSKNTSGWSYPKCALRDENRLAPDQFYCILNMDEGYLAFASDADYYGVAFTGLKGRELYPTVSAVWGHCEITMKYLGGLDPEPLTLLELCRRSIRLYLGKERICRVRELRLPIGLKKYLLYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6T0</accession>
    <name>A0A183H6T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4838 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3192</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002060">
        <property type="protein sequence ID" value="VDO35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6T0"/>
    <dbReference type="WBParaSite" id="OFLC_0000319101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000319101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000319101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000319101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42868" checksum="789F5B1DE431EA39" modified="2016-09-07" version="1">MTLIKKKAAEDSWVEQVIGAPLISNPVQIPDQHNMYVARYDSDGFVYFGKAWNESGVVECEFACRENKLKGSDIKNKIKILTYDGNHTIKGFFYEWVKFVKWLRHPNDEFRAPLRCGSSSGVILWPEKALGTLNIEKKTATFVYAEKIVSLAESELYDCLILMRNFRDRPPYCRCEECTKIDALEKETYSSDHLIMVNEWADYRIGDTFPKTKRLIKALDRPLNTLNGPQEQYVALWYHFGQAIMGRAWNENNKIAAAFVRKMPFLSKVIGSLQLLVQIPPSAAGFDYSWQPYAEVAKIGAKEWNPVHIGFASPCVLVIDQEGHEYLGSADLKEEFATTVIKNEVFRLEGRGIYNFKVLIATVFIMGFSDAMKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6U5</accession>
    <name>A0A183H6U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3206</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002072">
        <property type="protein sequence ID" value="VDO35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6U5"/>
    <dbReference type="STRING" id="387005.A0A183H6U5"/>
    <dbReference type="WBParaSite" id="OFLC_0000320601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000320601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000320601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="464"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000320601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62822" checksum="DB5D8BB4D1E33B98" modified="2016-09-07" version="1">MKHYTALGINNNSFNFQTVSKTINTLLRLSGTDALIHWICTRLLLLPPSGQAHCLPAYCAVLSTINPPPLIEAHILLALTRAIVSERFTIVLEYMPFMSKDYLTILARPALSSLTQLIKQSNFSPRSVQVAALLSPDHAVGETLLLNLLALNSDEVPLQSYSLALHALALLIIERADTKLMTEVMNRVCTLKTSASLLHMFCADLNQLKQLNLRDKLVTILEQALDFVKENCLAGEILWQSISTNLMDCQLRRSLLERVLNDKRLCLEGFLLTYYRQFPLPSFALGHYDSVENITGNSQQDALIAGRVFFDQGRAILSVDMDSGLRLTSRTPVGKHCWCFTREHAIRRQMNCVNNWLWKLALRPKKITVEITSNKVTTEDPFDKLPQLPRTLQADPIECNEMYFLIQQNRRLITSAPTFCRPEPMECSSRSLTEEKYVLWRTFAADLRLFSGMRQIPPSFNRDIRHLDHTCSREVHKVAVIYVAKGQEDKVSILSNSFGSAAFNEFVLRLGWQVQVGHQHYGYSGGLPNGVTAPYYASADTEIIFHVSTMLDGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6V2</accession>
    <name>A0A183H6V2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">inositol-polyphosphate 5-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3214</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.56" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01002081">
        <property type="protein sequence ID" value="VDO35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6V2"/>
    <dbReference type="STRING" id="387005.A0A183H6V2"/>
    <dbReference type="WBParaSite" id="OFLC_0000321301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000321301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000321301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039737">
        <property type="entry name" value="INPP5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997:SF2">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997">
        <property type="entry name" value="TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000321301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="47969" checksum="4B6B5510C14B1D11" modified="2016-09-07" version="1">MLCKVIKESNAHFIAIHMQEVGGKNFEECISQVPAFLNHLAASMHEMGYSTGRAYLDLEFDLPESYNALGSLFFINDVILPRIRQYDFITKQFVKLEKVFETYDHGLLKCRMLRKAKFPKDFWPSVKWGRKGYMHCRFRIDQTVFDFVNVHLFHDESNIALIHENPALYSENRKRALNFVLGELKRINEDDMHSCPLFLFGDLNFRLNLQSFLNRITDDADLREDSTESTQSSICSTDGYGDFLTANSPNTNELKPMTDFRRTVSAIEFRRSPDNSTSDIPSSCILRIEKKLFDYFNHKRLLNEWQGYLEDDREVHNFPYLRELSINFPPTYPWSENPDESESLMKTRAPAWCDRVLMNSRALEMVKRDKFAKYDSFGKDVCMGDHKVNIFIFFLLIKSLDFIFKIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7N8</accession>
    <name>A0A183H7N8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macoilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Transmembrane protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS3500</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of neuronal activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Rough endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002350">
        <property type="protein sequence ID" value="VDO36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7N8"/>
    <dbReference type="STRING" id="387005.A0A183H7N8"/>
    <dbReference type="WBParaSite" id="OFLC_0000349901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000349901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000349901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464:SF2">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552421" description="Macoilin" evidence="15">
        <location>
            <begin position="26"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="250"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000349901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="61520" checksum="1DAF6D22E47CE8FE" modified="2016-09-07" version="1">MYLWRVIWDLLWSIVLYILGGVVESSSSSLDDRISLSSNEMESEDEMMEQEETSSQPDDASPSSNRIRSIQRHPTVLIPSSGSYSQTKGGRSRGRHLQNHAGYILSPLTPGNALSSSTLSANCSLNNNLLNLAAGNIQQDRQMYSSVNSTGYQNISINNVNVVENGGLCTGSAANFNGKASDVEELLETLRNDLRAARSQEMELRNMLQHYMNGEKQLKGELQQLRLKQEQSDSKLANIMKTREQDKSTMQLLEKKLIDTQTKKNELEKELNVEKRSKMKEEHAAARALAAAQSNKIVECSEACKTKKADLEKELRIVRRELKAKEELISEHEEELQQLRQYKENNDLQELHATLRVIREKNTHLEKSLSAENRLKQKLFYALNEARGQMADFQQQLLAKEADLRLKDVELMNLRGRFANGTDDSIKLPSIGDNRGSLSVKATRLDPTSNVIPPSVVSNINGILKSYVPTEQDIFSCASNAYMPYSFTTHSSQDEHSLFDSSLTHSTSAISPDSVSPPPASSLSNVSSDAFHSTNSKFNSTSVNTNSLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8S2</accession>
    <name>A0A183H8S2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3882</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01002751">
        <property type="protein sequence ID" value="VDO38085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8S2"/>
    <dbReference type="STRING" id="387005.A0A183H8S2"/>
    <dbReference type="WBParaSite" id="OFLC_0000388301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000388301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000388301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000077">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO38085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000388301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21103" checksum="216D79943F8A3589" modified="2016-09-07" version="1">MTRPRVFFDITIGGQQSGRIVMELFNDVVPKTAENFRALCTGEKGVGKSGKPLHYKGSKFHRVIPNFMCQGGDFTRGNGTGGESIYGEKFEDENFKEKHTGPGVLSMFFLVIGERLCPNFRMEKGKVVLANAGPDTNGSQFFLCTVKTDWLDGKHVVFGRVVEGMDVVQKIEAVGSQSGKTSKDVVVANCGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9D6</accession>
    <name>A0A183H9D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4098</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002987">
        <property type="protein sequence ID" value="VDO38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9D6"/>
    <dbReference type="STRING" id="387005.A0A183H9D6"/>
    <dbReference type="WBParaSite" id="OFLC_0000409701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000409701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000409701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000409701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31403" checksum="653B53B36FEA1392" modified="2016-09-07" version="1">MYTALKRRDEYDRSDQANIDRLFLSKFNHWPHIFNLANCIVGVSMLAMPYCLQQCGILLGTILIGICSILTKLTCHLLYQGALLTRRRSYESMASHAFGNGGKRLVELLMILFLMSCIVSFMVVIGDIGPHVLADYLELQAPTQRLRILVMVVIFLFIILPLSLFRSVTSLSRINSITILFYTVFVLRMILECIPRIFDFNWIGNIRWWRQEGLLNSLPIISMALSCQTQLFCVTDCIKEPSVAKVYFSVLLERMLMYGARYYNIRIFSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9D8</accession>
    <name>A0A183H9D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4100</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002988">
        <property type="protein sequence ID" value="VDO38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9D8"/>
    <dbReference type="STRING" id="387005.A0A183H9D8"/>
    <dbReference type="WBParaSite" id="OFLC_0000409901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000409901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000409901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000409901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33650" checksum="EDFDB62C2E6F81CF" modified="2016-09-07" version="1">MDMIVSGAVNICSSMYTAVGLFGYIAFYDVELYGDILLYLQNSLLTQLLKLAFMLSVAVSIPLMLFPGRIAFYNFLMKPDACEFAMLRVPSLIFISLTVFLLSSCLLVAVIVPNVEFILGITGATIGSLVTIIIPSLLFLSISRGIEQYRSLIFYAKVSIIIGSLMLIGSTWAVLHTEQETNVVDIILPKRIDDEKVEIALRHLEKNTFSERKQKEEAVRSRKGRKKKQSVEVVTNQETTTVSGEIKEQRKEQDKILKGQEMTVDKLKKHNEMLEKITVTMAGISKEDVNVKQTKEIKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAA4</accession>
    <name>A0A183HAA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNApol_Exo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003343">
        <property type="protein sequence ID" value="VDO39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAA4"/>
    <dbReference type="STRING" id="387005.A0A183HAA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000441501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000441501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000441501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mitochondrial polymerase exonuclease" evidence="1">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000441501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16349" checksum="28282C2D1A090F68" modified="2016-09-07" version="1">MRARYNLSAVRKTWSFAATRWYTVEINSPEQPSTSKKNASFSLKKIDLVPERLHRHLFGNFPVPENTLKNDPFEALDLPNLEGSNLLDHFQNIAIKQFEPYRRLLLKAATIRKLPDLPKEWIFHPGWTRYEMNESPKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAK2</accession>
    <name>A0A183HAK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cwf21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4514</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003459">
        <property type="protein sequence ID" value="VDO40204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAK2"/>
    <dbReference type="STRING" id="387005.A0A183HAK2"/>
    <dbReference type="WBParaSite" id="OFLC_0000451301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000451301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000451301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000451301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39214" checksum="BCBFCB37223FA2DB" modified="2016-09-07" version="1">SGIPGQKSEEKVLKESKLKETQEGCGNEKKSDKKEGRSSNSSSLLKNNERKNARERPKHEKDKRHKRDSSRKRDESKDDARITRKKSDGKETKRNEEKDSRKESGKFRKSDKKDEKIESRRGDKEEKTKGGERESRRCEVAEKVEPELKKESKHKEHGDKRKSDTNRSDHKRPRLRSHSSRDEQRTDFNKTDQKFLTETSDVKKSVEVSEVGSLVRNETDPLLLNQKKSGVNSRTTLKAMDSVDGTEIHEAADQKRLDEIKISIEKELERKVEALPASSNYNMPNLTVELKSGGEKRVTRENIFEGATPNFNARQKIKMILLSESERKAADRSSKKRSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAM6</accession>
    <name>A0A183HAM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS4539</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003486">
        <property type="protein sequence ID" value="VDO40263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAM6"/>
    <dbReference type="STRING" id="387005.A0A183HAM6"/>
    <dbReference type="WBParaSite" id="OFLC_0000453701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000453701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000453701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO40263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000453701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29015" checksum="C48E7FA799F3C423" modified="2016-09-07" version="1">MVFANGTLWTNYRMKLTGPCDMNLKRFPFDQQKCILTFESFNYNTGEVRMSWNQPYPVILLKKIELPDFKLTNFSVIAVEQMYPAGWWDELTVAFVFKRRYGWYILQGYIPTYVTIFISWISFYLGSRAIPARTMLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDVWMLSGMMFIFLSLLELAVIGFMSRNEGAPKQLKKRSFISNDLNWKEMPSPRIGLRQFWVDQRSSTSLMNDHEVIPDTLIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAP5</accession>
    <name>A0A183HAP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS4557</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003508">
        <property type="protein sequence ID" value="VDO40321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAP5"/>
    <dbReference type="STRING" id="387005.A0A183HAP5"/>
    <dbReference type="WBParaSite" id="OFLC_0000455601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000455601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000455601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO40321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000455601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35289" checksum="6690B8B859DF5E6D" modified="2016-09-07" version="1">MICHCALVLLGWAFLLYLLYHLITSLYHLIYPFFIATPINLHKAAGGKWAVVTGSTDGIGKAYAFELAKRGFSIVLISRTQNKLDIVKEELEKEYGIEIRTIAFDFTSGSVNDYEKTVLLLLRELDIGILVNNVGVSFSYPEVIHKAEGGLQRLADIDIVNTLPVTLLCAAVLPQMVERNSGIIVNISSATSYTPLDLLSVYSASKKYVTWLSKALQTEYAQTNIIIQNLCPMFVATKMSKISRPSFFFVTAEDFVKSAVQTIGIVGETAGCFPHQLQIEIMKNLPEWVVVPYLSKKSKLVRKKALAKKARDIKAACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBD5</accession>
    <name>A0A183HBD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4797</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003832">
        <property type="protein sequence ID" value="VDO41083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBD5"/>
    <dbReference type="STRING" id="387005.A0A183HBD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000479601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000479601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000479601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000479601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33994" checksum="0DA943C10A5B6271" modified="2016-09-07" version="1">MFQDKRVFSFIAKAESSARHDCFVFLSEKLAEQITLTIGEAFDLAYQKFLEKNGRDLENKKQLIMLRKRIAELEQENNELKEKLYALQKQKESSVPPLPTSPMPREPPPGIIPNLMNDIIPAIVPPPAIPRRHHTNTTVITDQTKTMMISDPIANFPQVGRRLENLQLDKMEDLFDDEFDPRADEKKKIAAGGKKEKDKFGLDPFGDDFMNDVLSLERKPVSDVPSTSKHEPTPEQFDEMLSIVDKRLTELRDGFASGILAMGDTGDAARDLHNIYSTTVQSPETNTGEKDQTKATQNGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBF1</accession>
    <name>A0A183HBF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RPN7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003852">
        <property type="protein sequence ID" value="VDO41139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBF1"/>
    <dbReference type="STRING" id="387005.A0A183HBF1"/>
    <dbReference type="WBParaSite" id="OFLC_0000481201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000481201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000481201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit Rpn7 N-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000481201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14036" checksum="9444D374A1D9FBEE" modified="2016-09-07" version="1">MFTTKISNSQTNSKDHAATGVPIVPVEQFKAIEATEVENVAATSTSRPGHLAAKLTYAATRNMKEIIDSAKAKISAVAALNHLNMRNYRLVAEKCLKIEFDNFDYPALLAAKDVVMFGTLCALATFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBH4</accession>
    <name>A0A183HBH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GOLGA2L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4836</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003874">
        <property type="protein sequence ID" value="VDO41207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBH4"/>
    <dbReference type="STRING" id="387005.A0A183HBH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000483501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000483501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000483501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000483501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="67094" checksum="1E4079BB83A8CA5D" modified="2016-09-07" version="1">IRTSSHRQEKVLTDIAAAKSGSSGSDSWNCSTPCTICRELRQTKQPASTLQLQLAILAARLTTKIADNDALFRGNAELAQTNQRLQNEIDELREQMAKHTTSSSNAGISATNQQTVFEQWRIPEQLLNQSSEKKAIYAEDKERTEAKDFDARIVSSSEFQVVSQQPSLNQQIIECTPTNEIQTSNLREPEFDEQDTESLKKKLNAIQKYNSESEEKIEEIEDNAERLGRCLEVLEEYCLDLENKVEQLKDGSTTKQCEDAKHQRKLEVSQTNNEELLSLKSQNILMNFTGNHRTKGKGLKKQKDAVKGKLEEDKYEVKEIDCISNDTWVSFDEQVQDILQNDTVQDERIQLAQESEGQLQQKEIKIQELEEENRFLNQKLKSQQQLIEGLEKKLDMTEEYSMTLEVKNINIEQEILEQKKNYEELMIEKGRELTDREIVLEDLMTKLKHAQEKNIQMQRQLDDYSTQMSELQRKNEIDQELRQQLVEEQKKITELERKLDQMVVQNELLKNGEQKLTDALMISNEQLAKTESKNERLESEISNLQASLLKTEEMAKKTDNSEKSIVGTMNAVIEVHSKAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCG0</accession>
    <name>A0A183HCG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5172</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004303">
        <property type="protein sequence ID" value="VDO42267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCG0"/>
    <dbReference type="STRING" id="387005.A0A183HCG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000517101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000517101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000517101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO42267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000517101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40835" checksum="D468C173702A7D71" modified="2016-09-07" version="1">MKTFLSNKSDDIVPVTLFLHKPINFCFRILLDPKIGLGEAYMFEDWDVQSRIQDFLALLIRAKRYNAAMKLKQTNGWLRKLFNLLIYLIIRSIRSVMSLINVMQHYYRANSLYGSTKNIHEHYDLGNDMFNLFLDPSMTYSCAIFKENPSYTITHSDNKLLEEAQMRKYDRAFDMINPKSDDRILEIGCGWGACAIRAVKYYGCRWTGLTISMEQFKIAQQRIIDNGLQDKINFKLLDYRLENDVYDKIITIEMIEAVGHEYLPQFFETVRDRLRPGGKAYLQAIICPDLNYERYRRSSDFIKKYIFPGGHMPSEQAIREALPPELTITKIIHIGHHYSPTLDLWYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCI7</accession>
    <name>A0A183HCI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DBR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5199</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004338">
        <property type="protein sequence ID" value="VDO42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCI7"/>
    <dbReference type="STRING" id="387005.A0A183HCI7"/>
    <dbReference type="WBParaSite" id="OFLC_0000519801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000519801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000519801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000519801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26548" checksum="3994B8417045D6F3" modified="2016-09-07" version="1">MHVPEKYRRLQSFHRYYSGESEAPVLTIFVGGNHEASGYLQELPYGGWVAPKIFYLGHASVVRFAGLRIAGLSGIYNKNDYNMGKQFTCHWERPPFIDYGAVVSAYHVRSVDIFRLKQLKPRNPNESPIDIMVTHDWPAGITDYGDVKQLLKLKPYFEEDLKKNALGNPASMTLLHVLKPRYWLAAHMHCFFAALVPHSSKNDSENDFQPTRFLSLDKPLPRRHFLQVIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCJ2</accession>
    <name>A0A183HCJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5208</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004349">
        <property type="protein sequence ID" value="VDO42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCJ2"/>
    <dbReference type="STRING" id="387005.A0A183HCJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000520301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000520301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000520301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000520301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15844" checksum="BB847FFF410D2392" modified="2016-09-07" version="1">MRASNYLLLYRIAIVLWIAVHIIHIITIVTSILATQLIRPELLYPQLVMLIISVGFYIFTLLSIITMNFIGSTIIWMAPLIASFFCFLTLTNLYLIVLTHRYVDDRREALQKILRNTKTVTFKEIRSSIKQYEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCT2</accession>
    <name>A0A183HCT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5294</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004478">
        <property type="protein sequence ID" value="VDO42657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCT2"/>
    <dbReference type="STRING" id="387005.A0A183HCT2"/>
    <dbReference type="WBParaSite" id="OFLC_0000529301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000529301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000529301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552483" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000529301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9439" checksum="1846018FD8D113C3" modified="2016-09-07" version="1">MHMPQLVAIGLVFAAYFQVSHGNVDPSRIDLSSSTAKVVRKCSMRGVCGHRGDMHQTCPYHGPPLRISVEKHRQTLASLCPHLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDC7</accession>
    <name>A0A183HDC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5486</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004741">
        <property type="protein sequence ID" value="VDO43317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDC7"/>
    <dbReference type="STRING" id="387005.A0A183HDC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000548801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000548801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000548801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="258"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000548801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47556" checksum="7D1D93CDD2129EC4" modified="2016-09-07" version="1">MSSILRGNEGKWLMEALRCNDLLSLSIAEYNKISKDNYRWIPVEILDINGIYNTGVHFSIKIAIALSNCTKVVRILNNKSAYLSFKSLLILLQACVFEIFRPTWRKSAKTKLLTCSNYDSSEELIETSSRASDASVAVDMKSQESTTNVSQEWLEPKTLMLWNNFLNFVNKFKTSYSSKIEKLNRFKIYMQNMHFAQKLQYEEKGTAIYGETQFSDMMPEEFRKIMLPNLWWQSVESNRKNPNIDFDLEKFNLSLNNLPRSFDWREKGVVTPVKNQGSCGSCWAFSVTGNIESLWAIKKGDLISLSEQELIDCDVVDKGCNGGLPINAFREIIRMGGLEPEDQYPYKAKNGTCHLVRTEIAVSIDDAVEIPRNETIMQAWIAQRGPLSVGEKAYKTLSDTLTLHIRVVVVVADKILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDS6</accession>
    <name>A0A183HDS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxisomal multifunctional enzyme type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5638</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004952">
        <property type="protein sequence ID" value="VDO43811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDS6"/>
    <dbReference type="STRING" id="387005.A0A183HDS6"/>
    <dbReference type="WBParaSite" id="OFLC_0000563701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000563701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000563701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO43811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000563701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24379" checksum="486936EA1013DB81" modified="2016-09-07" version="1">MCKFRALLQTVAEIKFHGGKAISNFDSVECGQKIVETAITHFGRIDVVVNNAGILLDKSFQNMSDNDWDLVYRTHVKGAYSVTKAAWPFFKKQRYGRVIFISSNSAIYGNFGQANYAAAKNALIGLSHTLAIEGNKYGIHSNVVIPTASSRMTAHLFSEESLRALKAEYVVPLVVYLAHESCQETGKIFEAGAGWFGQIQAYRSKGIVIPAASVEDIYIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDU4</accession>
    <name>A0A183HDU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carn_acyltransf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5656</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004973">
        <property type="protein sequence ID" value="VDO43863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDU4"/>
    <dbReference type="STRING" id="387005.A0A183HDU4"/>
    <dbReference type="WBParaSite" id="OFLC_0000565501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000565501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000565501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000565501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43004" checksum="50A8D0AB7E393F75" modified="2016-09-07" version="1">MKYFADFTLTDSIRQKIQEAQQKHVAIGSKVRFSAAEYFEMNRKFIKQSKLSPDSIMQLAIQLTFYKLFKKFVPSYESCSTAAFLKGRTECVRSATSATTNAVLAIENNKSNIGELLKQCSAMHSQLVKEAATGQGFDRHLMGLRCTAERLGWLQPKLFSSAIYKYMNGFILSTSTLSTETIAFGGFGPVVPDGFGIAYNILSNKMGALISSYKAIIIMLRLRLRRLLLRQLRMLSSDYKNREVMTDYHITPFGNVISDDNDQGPRTTLSRLNDEMLECQQIGIGSISKYGFRLYDGQFLYGPIAIFPKAVLSWRVLTPDDITPESVRFFTMLEPKLDVLVVGPGDRQHVDPVRRRIAPFLSKHNIGLEIMHSASFLYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF70</accession>
    <name>A0A183HF70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FCP1 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6134</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005668">
        <property type="protein sequence ID" value="VDO45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF70"/>
    <dbReference type="STRING" id="387005.A0A183HF70"/>
    <dbReference type="WBParaSite" id="OFLC_0000613101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000613101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000613101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000613101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14316" checksum="CD19D3FC5C5DD110" modified="2016-09-07" version="1">MVSQWFDLVIFTASMEIYGSSVADKLDNGKGILQRRYFRQHCTMDYGGYTKDLSAVHADLSSIFILDNSPSAYRKFPQNAIPIRSWFSDPTDTCLLALLPFLDALRFASDVRSILSRNQQLQQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF82</accession>
    <name>A0A183HF82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6143</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005685">
        <property type="protein sequence ID" value="VDO45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF82"/>
    <dbReference type="WBParaSite" id="OFLC_0000614301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000614301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000614301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000614301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14606" checksum="36FB9ACB4C15AA2B" modified="2016-09-07" version="1">MGSKVTPATTSETAAKGQKIGKGNRNQFWSTNFIKSDEQTPKRAEIPVSRQFLPKKKHGISEAWSKQMQESREDLKQPFPYTPFKSGSLSKKTAINVLRDVTLNTHLPNQNSSQVFGAQQQPGQYFSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHN2</accession>
    <name>A0A183HHN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6991</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007008">
        <property type="protein sequence ID" value="VDO48771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHN2"/>
    <dbReference type="STRING" id="387005.A0A183HHN2"/>
    <dbReference type="WBParaSite" id="OFLC_0000699301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000699301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000699301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000699301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12028" checksum="82A133E07CD29C42" modified="2016-09-07" version="1">MIRLSNDHSLSIDSRRIATADELLANELTDDETQLNSDPNTSMQTIKTVSDKDESVFLVSVPITSELECDTVEQQQRLHPVMSFGNKMLIVKVEQRENPSSNAAANSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHQ8</accession>
    <name>A0A183HHQ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS7021</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007063">
        <property type="protein sequence ID" value="VDO48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHQ8"/>
    <dbReference type="STRING" id="387005.A0A183HHQ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000701901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000701901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000701901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000701901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20460" checksum="E4FC664C2AD5560E" modified="2016-09-07" version="1">MHTVWARANAIFAFMLSVLSALTFCVFLSTVWLPNSAPVTLSANNVRVKSFVDYASEGSRSDVAMAELNIKVNIAPIFNWNVKEIFLFLVAEYSTPKAPLNQIVLWDKVVRRGEWYTIHEESITPKYYFMDDGTNLLNHKNVTLVMRWNVVPNAGYLAMAQGEGQYRIEFPSNYYSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV4</accession>
    <name>A0A183HJV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4097 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7768</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008322">
        <property type="protein sequence ID" value="VDO52439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV4"/>
    <dbReference type="STRING" id="387005.A0A183HJV4"/>
    <dbReference type="WBParaSite" id="OFLC_0000776501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552561" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12935" checksum="07CD84095E9ABD46" modified="2016-09-07" version="1">MLFLLIHLLLLIHIPIVELTSTLAPNHVAINPKRKHIDADTSWLEPEKNEVQKVSIDASNPDKVILDLINSGKQLSASAQGNMAVAESDGQRAQVQRFGDKGGIAQVEGHKYVSLSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK78</accession>
    <name>A0A183HK78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variable large protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7892</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008543">
        <property type="protein sequence ID" value="VDO53022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK78"/>
    <dbReference type="WBParaSite" id="OFLC_0000788901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000788901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000788901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000788901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="5892" checksum="52B68B00638B1185" modified="2016-09-07" version="1">MYVRDINKVRFEAQTSAAVAAVVVAGAGDNREKMLVNQRLLIKVLSMLFNILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKV3</accession>
    <name>A0A183HKV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8115</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008931">
        <property type="protein sequence ID" value="VDO54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKV3"/>
    <dbReference type="STRING" id="387005.A0A183HKV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000811401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000811401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000811401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="269"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="368"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000811401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45817" checksum="E8C331F383B5580F" modified="2016-09-07" version="1">HIISKKDEEGHHTLTIKEARLEDVGTYSCKAVNVAGTEKTEAKFAVISELSAPLFTDEIGELEIQEGEKAELTCTVVGKPTPEVTWLRNDVEIHIDNTHFFKKDDENGKQMLIIASVNKEDFGTYTCVATNQVGTAKTIGKLNYPKYGFEKMREEEVKPIFIEPLETHTAKEGETVSITCRVNVNSGADIRWYLGDKPIESDEHMIVEKLENGIIKLTIENATKEDVGVYRCEAVNKSGKAATAAKLNFATEDMEMVEDESALIGFIQPLNDVVTAVNSEAELLCTLNVTKDDVQIKWSKDGLEIPAQRVTIEQLVDGTQKLKIANVTADDIGTYRCTASIGDSSVWTEGKLTILEATKEAAEDEGPPKFIEILKSCTVTENSEAVIQCKLQGLPRPTISWMKDGVKVSFHSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKW6</accession>
    <name>A0A183HKW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008958">
        <property type="protein sequence ID" value="VDO54140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKW6"/>
    <dbReference type="STRING" id="387005.A0A183HKW6"/>
    <dbReference type="WBParaSite" id="OFLC_0000812701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000812701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000812701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000812701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15479" checksum="72B984587FFAF0AA" modified="2016-09-07" version="1">MYEYEREASEWLHWVERATRLMDDRQLPTNLGELRRLEHDMERFKSEDLPPKAREKQRLADHYAELHQLFERTEHLHIPVELSTQSLDRSWQRLLRSLNERFSLIEEQAGVQVFEDAKMVALLFLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLX4</accession>
    <name>A0A183HLX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Internalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8486</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009638">
        <property type="protein sequence ID" value="VDO55897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLX4"/>
    <dbReference type="STRING" id="387005.A0A183HLX4"/>
    <dbReference type="WBParaSite" id="OFLC_0000848501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000848501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000848501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000848501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9931" checksum="922291685A3C6884" modified="2016-09-07" version="1">MTETVTDQEKQENAKVDKQEATKDESTERKESETFELGSNKSTGQNSSLSLEQPGIIKTDNVQTVDDFKNLMYKVSIVIIIFKVSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM72</accession>
    <name>A0A183HM72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8587</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009838">
        <property type="protein sequence ID" value="VDO56384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM72"/>
    <dbReference type="STRING" id="387005.A0A183HM72"/>
    <dbReference type="WBParaSite" id="OFLC_0000858301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000858301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000858301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF5">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO56384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000858301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14630" checksum="A884CAA4C058760C" modified="2016-09-07" version="1">MAGTSLIGLFVAFCCEPKNQIPRNLMPALFGFIATTISICCGLNMGSPVNPASDFGGRIFASLIGYGVQLFTFHHYFFLVPLLAPIVGAAIGVYSYQFFIGFHIPKPITANINKVKWDMDQENQLKQVSESSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HML3</accession>
    <name>A0A183HML3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutL_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8725</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010092">
        <property type="protein sequence ID" value="VDO57073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HML3"/>
    <dbReference type="STRING" id="387005.A0A183HML3"/>
    <dbReference type="WBParaSite" id="OFLC_0000872401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000872401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000872401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="1">
        <location>
            <begin position="37"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000872401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23890" checksum="7822CEAB48D52518" modified="2016-09-07" version="1">MQKISCCVYFSFLKKNFSHCNIYLFQLQPPKIAKITVLGPSGSIFIIESEGLSLKKLLDFLTASLEKIGSEFQLSKNDYSKAFEDKGVIIVSAIKADKILSLDEMEEICIELDCDDVNKFEEDGATFYELICVRNKFAQLLAAIEEQGFDVKCSALQSYAINPVEINKHDTEMITQLYQTLRENENITQVYANIRPNSIPIRPLKLKAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN14</accession>
    <name>A0A183HN14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IBB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8876</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010402">
        <property type="protein sequence ID" value="VDO57827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN14"/>
    <dbReference type="STRING" id="387005.A0A183HN14"/>
    <dbReference type="WBParaSite" id="OFLC_0000887501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000887501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000887501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000887501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23975" checksum="90091B98566B894F" modified="2016-09-07" version="1">MTVFKMVNEFALEYRTTRDKILQQRKRLADKRERNKTRGKIWALEGQNGKDGVELNGNLKNRTSIQMNAEQRHEAMSRMLTEGSSDDTLKRTRAKPSIERSPADIISNQREMLKSVGRLIDSGSPGRESHDDEILDGLVKAATIQTEPRDHRRRARQFNRKSCKFFFSFFLLLEVNLKNFSIVELEIIRISSYFHQQISLYFYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNW1</accession>
    <name>A0A183HNW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010970">
        <property type="protein sequence ID" value="VDO59011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000917201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000917201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000917201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000917201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15225" checksum="3B4ECFD2F6171723" modified="2016-09-07" version="1">MDKSSSPTAKRPKFSDVMKDLETELSEKLENLSKGDLAWINRARSGRIVKWPILVLKVDNINKSCVCTELPLDDMSANAEWCLNSEKTRVVQLKNIYLYDTVEAKVDEIEDEELKAAIQQADEIAEGSYQPFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPE8</accession>
    <name>A0A183HPE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sel1 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9360</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011396">
        <property type="protein sequence ID" value="VDO60023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPE8"/>
    <dbReference type="STRING" id="387005.A0A183HPE8"/>
    <dbReference type="WBParaSite" id="OFLC_0000935901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000935901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000935901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552588" evidence="3">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO60023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000935901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28034" checksum="86EBCC001D7AD226" modified="2016-09-07" version="1">MILRWVAVLLFFLPFLFGIKSNSHSLKDDNSNSDGKDEKSGKKEERTPDRLVLLNDEGEVMDTMSQKQSPATYDITNDDIERMSNTASEVSTMPSAGDEFTIEKVTKRTEIELTETEKRGDELYRTAMRFLDKERAASSEAKKAAYRLLDEAAQLKHKEAMKLIAYAYLFGDYTRWNIDEARAIFEELAAGGSADAQLALGFMHATGLGVPESSQAKALIYYTFSALGGNPLAQMALVRFFSLFLVFNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPW8</accession>
    <name>A0A183HPW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome subunit alpha type-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9528</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011765">
        <property type="protein sequence ID" value="VDO61201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPW8"/>
    <dbReference type="STRING" id="387005.A0A183HPW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000952901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000952901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000952901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO61201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000952901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12429" checksum="673EBE83D3A13DAF" modified="2016-09-07" version="1">MSSIGTGYDLAAATFSPDGRIFQVEYAQKAVDNGGTMIAIRGKDGIVTAADKLITSKLYVENANPRMANVGEYIGCAMAGVYPDCRALLDYAVNESLNYLKEYRTPIPVKKLANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ38</accession>
    <name>A0A183HQ38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011946">
        <property type="protein sequence ID" value="VDO61806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ38"/>
    <dbReference type="WBParaSite" id="OFLC_0000959901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000959901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000959901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000959901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9233" checksum="E815C33765D9B6DB" modified="2016-09-07" version="1">MADTNKPDFPNIPVVTDEQLKNAEKHDFLKTIGNVFNGIREHSNGSEGSNGKNLTLHINLNFRKSELEKLAALKNSSILEQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQE3</accession>
    <name>A0A183HQE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9703</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012191">
        <property type="protein sequence ID" value="VDO62611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQE3"/>
    <dbReference type="STRING" id="387005.A0A183HQE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000970401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000970401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000970401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO62611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000970401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15156" checksum="F35FE031CCF75803" modified="2016-09-07" version="1">MDGYNVCIFAYGHTGSGKTYTMEGLPNDPGVYQRSMNHLFRIAEDRLKDIDYTISISMLEIYNEKIRDLLSNNKCNLPIRIGDNGILEIPGLLVFNVNTQQEVQEILEKGRMNRVSNLRICDIFSLFICFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQK4</accession>
    <name>A0A183HQK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9766</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012326">
        <property type="protein sequence ID" value="VDO63091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000976501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000976501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000976501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000976501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7602" checksum="AA295F68BF4E68DE" modified="2016-09-07" version="1">MSLLPMKNLSGSFPVLFIEARLQGPPEIVLSQMGISIDASDYNIALLSKFLVFIILEFLKLGKFEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRL6</accession>
    <name>A0A183HRL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10129</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013200">
        <property type="protein sequence ID" value="VDO66077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRL6"/>
    <dbReference type="STRING" id="387005.A0A183HRL6"/>
    <dbReference type="WBParaSite" id="OFLC_0001012701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001012701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001012701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001012701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11124" checksum="94E150E9D02CC68A" modified="2016-09-07" version="1">MNGYNGLFGECASTERRALIVSNPAEYILKKVLSTQLEQLGRKGYTLEDARTQCLIAYFKVVLMLQLKYDLNFCNVVNPENIWRVLQVDISFFHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRP0</accession>
    <name>A0A183HRP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10155</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013253">
        <property type="protein sequence ID" value="VDO66266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRP0"/>
    <dbReference type="STRING" id="387005.A0A183HRP0"/>
    <dbReference type="WBParaSite" id="OFLC_0001015101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001015101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001015101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001015101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17744" checksum="313BB9DC7A9DFC7A" modified="2016-09-07" version="1">MTADLHNARDELRSTLNKCSMYETNIDALKLQLRCQSQNCTKLDEKLKRAFEEIDNLTKQKDDLSIALSKAKIVLKRKTDLGSQAAGTIECIKGELNEAKKIEDQMNERLRKLNKDKEKVKQMLSERELDVVKLECRLVESTNECKKLLFLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRT3</accession>
    <name>A0A183HRT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10195</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013330">
        <property type="protein sequence ID" value="VDO66597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRT3"/>
    <dbReference type="STRING" id="387005.A0A183HRT3"/>
    <dbReference type="WBParaSite" id="OFLC_0001019401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001019401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001019401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37860">
        <property type="entry name" value="AGAP008810-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37860:SF2">
        <property type="entry name" value="VITELLOGENIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001019401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20070" checksum="BDD2F2F7410D58D7" modified="2016-09-07" version="1">MPWQKIDGIDGAVLISVCRKDHWTVLQTYEGLCVRCNSQFDICEIVLPGRMHGRSYGLLGLNDNEPSNDRDLVDGTSNDQLNVLAEHWAINGECRVNQARDLTHRDDDRCQEYFQSSDSPLELCFNQIRPKPFEEICSNGGKQQRCTATSAYLQVCLKAGIIIALPHECGKKLLFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HST4</accession>
    <name>A0A183HST4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS10546</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014165">
        <property type="protein sequence ID" value="VDO69334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HST4"/>
    <dbReference type="STRING" id="387005.A0A183HST4"/>
    <dbReference type="WBParaSite" id="OFLC_0001054501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001054501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001054501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO69334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001054501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21379" checksum="E876B7CB94A114D3" modified="2016-09-07" version="1">MRLLAKLPTIAALIYRNLYRDGTLASVVSSSNDWSANFTSMLGYKDPNFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAAMAGLAGPLHGLANQEVLVFLTKCKKELGDNYTDQQLSDWVWNHLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPKDPMFHLVSKLFEFTPGILLKQGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT46</accession>
    <name>A0A183HT46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014432">
        <property type="protein sequence ID" value="VDO70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT46"/>
    <dbReference type="WBParaSite" id="OFLC_0001065801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001065801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001065801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001065801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21101" checksum="EAB4EE00A55F6B4C" modified="2016-09-07" version="1">MSTDVNHFHMQNSNYQSQSSFMDYLQQCSQQYSTDSRQPYDIPPQYPLPYHWSCLGQRPNGFPHTHKIPQRVGGSVMVYRLLFRPPFTWTYNCFCDCEEFVAFSIEISSEFSRHPEMNTIYVPRVPGQHMNFAEANKYVKGQLREAVRKLKSTQNFKFQKRISTSCLIIGPQHFHTIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUE7</accession>
    <name>A0A183HUE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aggrecan core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015617">
        <property type="protein sequence ID" value="VDO73918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUE7"/>
    <dbReference type="STRING" id="387005.A0A183HUE7"/>
    <dbReference type="WBParaSite" id="OFLC_0001110901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001110901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001110901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001110901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42357" checksum="596A684F7EE455DE" modified="2016-09-07" version="1">MINDETIVDVEPVMSWEMDKNASSTTDFLVKKTGTDEKLNNSEQSSILPDLDINDFAYSLEDLLPSSTSTNLDDFVNLRKNFSEEIVERKENEAELKASTISESVQRISSSRNDYDENKKIKSKHRSSHILNLIEMESSITPMDNGTAISEVSEIISKGSSVARSSTTTIIPDVLETTRDENIGQFALEKSTSTFATDLLAILTKSSRDFTETLTTTSLSASDKELLMTTNEPRLTDDLQKSSSSQTANSLFEDSDLSTLQTTMSSDDAIDVVGLISDTNQRLISDSGSSTIPSVIPITSSTTDESKISDSFDHSTESSNLNMENFITFAETSMIKPEDTVEVVKEIDDITTSTVSEVKTITSTGIPKAVFNITIPSSLVDPKYLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV41</accession>
    <name>A0A183HV41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine gamma-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11353</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016314">
        <property type="protein sequence ID" value="VDO75840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV41"/>
    <dbReference type="STRING" id="387005.A0A183HV41"/>
    <dbReference type="WBParaSite" id="OFLC_0001135301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001135301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001135301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001135301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10540" checksum="8DE78B51280957A4" modified="2016-09-07" version="1">MKFLSPIARFQKQEAIPGQLCSLGFTCMASNLYSAPDAVKAYLNSVASLHKIPIGTKTTENRLDEVCEALKNSHRLFLTDSLRVIFKLLFCNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVA0</accession>
    <name>A0A183HVA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016443">
        <property type="protein sequence ID" value="VDO76210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVA0"/>
    <dbReference type="STRING" id="387005.A0A183HVA0"/>
    <dbReference type="WBParaSite" id="OFLC_0001141201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001141201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001141201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001141201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10560" checksum="CC3E1CB46C3D64B5" modified="2016-09-07" version="1">MQEQQNNMLLAAYRNQLLAAATNNPMTLKDSLNLDSVDQEKLQSTMANITTSGTTGSAGGLSMATEQFNPLSSLSMLQSPYNPISPLLGSQFNPFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVV9</accession>
    <name>A0A183HVV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPAT_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017027">
        <property type="protein sequence ID" value="VDO77924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVV9"/>
    <dbReference type="STRING" id="387005.A0A183HVV9"/>
    <dbReference type="WBParaSite" id="OFLC_0001162101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001162101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001162101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPAT/DHAPAT C-terminal" evidence="1">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001162101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14637" checksum="AEDA51150129922A" modified="2016-09-07" version="1">MQLRETDNSIEFFLEGARSRSGKSLYPKFGLLQMCVEPFFRCQLYDLIVVPVTIDYDKILEEFLYAYELFGFPKPQETTAGLLKSREILNKRFGHIYVNFGEPISLRKYFDGRMNRWHPPWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW47</accession>
    <name>A0A183HW47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DOCKER domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11707</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017260">
        <property type="protein sequence ID" value="VDO78576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW47"/>
    <dbReference type="STRING" id="387005.A0A183HW47"/>
    <dbReference type="WBParaSite" id="OFLC_0001170901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001170901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001170901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001170901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22564" checksum="B94D1AEBE7EEA08A" modified="2016-09-07" version="1">QIITPILEENRDYRHLAQVHNCLNQALSRIEPTISMIEDIADAWYSPLPSADKRCFGTYFRVGFYGSRFGDLDGVEFIYKEPAITKLSEISHRLDVFYADRFGKEVVEIIKDSNIVDRNRLDSTKAYLQITYVEPYLENWERRRRPTYFERNHKLYRFVYATPFTKDGRAHGDLKDQYKRRTVLTTQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWF2</accession>
    <name>A0A183HWF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS11815</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017578">
        <property type="protein sequence ID" value="VDO79468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWF2"/>
    <dbReference type="STRING" id="387005.A0A183HWF2"/>
    <dbReference type="WBParaSite" id="OFLC_0001181401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001181401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001181401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO79468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001181401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17861" checksum="3A74A80D5C2FC766" modified="2016-09-07" version="1">MDTAIFMFGMIINVYEGFPKFYPLAMLGGAFWAVGNATAIIILKSIGLGMGVLIWGMASCLMGWASSRFGLFGLKQNIPNNVTLNYVGLLLILSGGALFSLVKPTPQTNDDNKIQEKRKNKSTMDIEPSNLLLKSSENDYEEMELSKNGDKKNESSIKKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXQ7</accession>
    <name>A0A183HXQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA-processing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018839">
        <property type="protein sequence ID" value="VDO83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXQ7"/>
    <dbReference type="STRING" id="387005.A0A183HXQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001227001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001227001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001227001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001227001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12913" checksum="5F33F8C886C09D4F" modified="2016-09-07" version="1">MPTEVAEQNKVKKRRKMKRKRIRSVREVASEDELVKKRLNAKFKMKTQRSNDDGMPCLRLSKKEQMVVKNGEKHDVLLKRSQEALLNRLNQVNIHLAITSNFMSDYVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ51</accession>
    <name>A0A183HZ51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS12763</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039926">
        <property type="protein sequence ID" value="VDP12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ51"/>
    <dbReference type="STRING" id="387005.A0A183HZ51"/>
    <dbReference type="WBParaSite" id="OFLC_0001276401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001276401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001276401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11722">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000009">
        <property type="entry name" value="Stromal interaction molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="262"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001276401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="660" mass="74147" checksum="4CCAE3B6E69D0C0E" modified="2016-09-07" version="1">LAYRSLISEASEVCSPNCSKLWTNNPIHESAEEVISCCLFKWTHFVIFRILSNISFLDVLITANDEKLRDPEGYEAIAQLHHQMDDDQSGSIDRFESTDFLKEDMQLGGSDRAQRERAFHHNHDELITVDDLWEAWFASEERSWTTVDMVNWLENTVRLPQYATIFIEMEIDGRALPRMAVANSTYLLSDLGIKNSVHKQKLRLKALDVVLFGFSGGNASWLKDIVLSILVIVLVTVLFVLKMQRTRSRMQMEQLTSKLSQLRSMQNNFEDIQRKFEEEQKRRQSTRGALENEQVETLKSQLMEAERLLENSGSAPLALQPLLRRTCELEVSYVGQQRMECIAEMREAIEHIDKLRKKQSSIVSSIKLATGASSGTDHIDSRIFALKARMEKISLAMSECHQRWTEIESLCGFPLVPTSATAEIMFPSAATNDVLSRTGSCNSFYRKSVGTTVATSMALSSISGNNPLAIIETSSNISDQVLSSVCSCACENFTPAGTRYLDSLNLQKHIHENVNESRPLKFAADSNELLHRSASSGSFNKLRHLRSIADMQKSRNQSTTSILATINDDDDGISVASNVNEIIAPTVLSPTTVTSRFSPFKQDLKLLKQNVSNVVLKSSSSNTKTNGFMVIKEKNSSDMSTISCNRKSKLRNLFHKTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZM8</accession>
    <name>A0A183HZM8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid synthase</fullName>
            <ecNumber evidence="2">2.3.1.85</ecNumber>
            <ecNumber evidence="1">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS12940</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="2"/>
    <dbReference type="EC" id="3.1.2.14" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01039984">
        <property type="protein sequence ID" value="VDP12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZM8"/>
    <dbReference type="WBParaSite" id="OFLC_0001294101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001294101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001294101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.20">
        <property type="entry name" value="Fatty acid synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="16">
        <location>
            <begin position="1250"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1336"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDP12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001294101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1658" mass="187233" checksum="E350F1B67DE00C50" modified="2016-09-07" version="1">MESFYPSSGSFCFPVSFLSEETFLLDHIIDGRVLYPFTGHMVLAWKTIAKLNGVDFLKTPVILEEIRVYSATIVTKPIRLDVIVTPGNGYFEILDGDQLAASGYIRIIDKDMPFYYKNVGEIQTSEVAERIELDTEDAYKEFLLRGYEYGQAFRGIYRACNSGERGMLYWTGNWVTFLDSLLQTALLAERADSLRLPTRVRYLRIDPIKHMEHIQEIDGIQVIELRNDIATNGCIAGGVECCDLTAHTVARRLQSAGQLYYEKIYFTKHFDKKAFDEFPQIREELNAYRDFLRSILANGLAKWEVNGCLKELINGALLSDAVRKFTRFMNPVSEAEHKRWLDDSQSPIATVFDEIFAIEIGDNSKDLVNKVAEKMQSMLKIFNVDRLWSAAIVHDRILKTIQDTCIENSTGHKCKACALEFNSTEQLKFCVDAVNSHPLLEMEWLCVGPKVDDMDESTLIQLGVKKVKAVLDEKQFVPAAEIRNCDLIILDKMLSRKKEVVQYLSRCKEMLRDDGFIILVETTSDYEIALAIQGLSAETISISDSGRIYGAYFTHDQLLKLFEECGFLLCNYQTDPSMMTTMYAIRKIPSQAREPIVIDVDDIEEFTWIEPLQKAIEERLNEPDYKTIWLTSTTVRNNGLLGLALCFKQAFNIANVILDNARQQYLVQVTFAYVTENISNWKNCCFSEENLKSNRFRTLIDMSVKKENRTGPAQIRMDDESVKQLMKLDLHANNYRDGVWGSMRHVVVKEDDMHLYKDVDHAFINTLIRGDVSSLTWFESPNQFFEDTRQKNSSLELCHFSGRLKDGTRLMGILPAQALATSVIVNREYAWAVPDNWSLADAATDRHFANSRNSDFELHIRHQTRGRGVDVVLNSLAQHMLQASIRCLAQNGRFLEIGKVDLSQNSPLGMAVFLKNITFHGILLDAVMDPSVGKKEDWQEVARLVQDGIKSGIVQPLSYTAFSSEKAEEAFRFMSSGKHIGKVLMEIRQEEPERVCVPSPIKVRAICRTLCHPNHVYLITGGLGGFGLELSQWLINRGAKKLVLTSRMGIRTGYQARCVHFWRRTGISVLVSTLNIAHLSDAHELMSQCKALGSIGGVFHLAMVLRDCLFENQNVQNFKDAAEAKYWGTLNLDAATRNACGKELRWFVAFSSITSGRGNAGQTNYGWSNCTMERIIEHRREDGFPGIAIQWGAIGDVGVILENMGDNNTVVGGTLPQRMPSCLAALDLFLSWNHPIVASYIKADIGTKKVGSSGNLWQTMAHILGVNDASQLNPDANLGDLGLDSLMGVEIKQALERDYDIVLSMKDIRTLTLNKLQQLVDSGGTASTVLQTTELELKKESEKEAEQNTVEQLERQMNQLFKMRVDVNDLEPMDLIVKCNKVEVGPPTFFVHSIEGIATPLKKVMSKCNFPAYCFQSTREVPQDSIEKVARKYIMEMKKIQPEGPYRIIGYSYGACIGFEMATMLQESDGANSVEKLILLDGSHLYMQTYRNVYRMAFGVTGDTLVNNPLFESEIMCAMTLRFANVDYKKFRVELLQQPGFKARVQKVVDTVMTTGLFKSADTIDFACCAMRSKFVMADKYKPERKFKGLVTLIRAEQGAAREEDVGFDYGISQVSDDNKVYIVEGDHDSFVQGKTSGKTVNIINDLIAETNKKIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZU9</accession>
    <name>A0A183HZU9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">OFLC_LOCUS13011</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01040010">
        <property type="protein sequence ID" value="VDP12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZU9"/>
    <dbReference type="STRING" id="387005.A0A183HZU9"/>
    <dbReference type="WBParaSite" id="OFLC_0001301201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001301201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001301201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000031">
        <property type="entry name" value="splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF575">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="17">
        <location>
            <begin position="145"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="343"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="857"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDP12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001301201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="889" mass="98172" checksum="233577E21EF59E13" modified="2016-09-07" version="1">MSLATNFPHNKKRTLYVGGFGEEVNEKVLQAGFVPFGEIVSISIPLDYETGKHRGFGFVEYELAEDAAAAIDNMNDSELFGRTIRCNFARPPKANERSQRPVWADDEWLKTICSESCEHSGKSLIYVRHWIQNRWVGLVAQIFCGYMVNFFEKYIGRIVIELRSDIVPKTTENFRQLCTGEKGFGYEGSHFHRIIPRFMIQAGDFTKGDGTGGKSIYGPKFADENFKLKHSMAGIVSMANCGPDTNGSQFFICTEKTDWLDNKHVVFGHVVEGMNIVKQIEQQGGKNGKPMMQLSRYLTILAVTKKKKRNTMSRSRDKTGGNTEPMPFVRKFGAAAVAAAAAGEPTVETMENAEESSNGNVPESYAPAVPEYLSPKQRSSRSRSRSRHKRKRSRSRNHSKRRSRSRDRRHSRKRSHIDKLKTEDDGTGVISETGQPEKKPRKSRWSTNKSFVPGMPTILPSNLSDDQRQAYLRKDLYFLLLFHTFCIKIVQLEVEDATRKLRLGDFMGNPDPALRSPSPEPIYDASGKRLNTREIRKRQELEQLRHEKIQALLKLNPNFKPPADYRAPTIRLHDKVWIPQENHPEINFVGLLIGPRGNTLKALEAETGAKIIIRGKGSVKEGKLGRREGPMPGENEPLHAYVTGTDYTITSIINEALMIPDGQNELRKLQLRELALLNGTLRPEDLASGARCSNCGSDEHKTWECPDAPNVTANIVCTACGGAGHIAKDCKNPRPGSGLFNVGDGGMDDEYTALMAELGEKPASRPYNAAGKPGLGSGSGGSGYKPKNYSLPSGTPIVRINLARQEGMEGYSSKGGAPPPLGGNSVSGSTEGIHFFNTPRPRPSYMPNAAAWGSPAGRGWGGVPPPPTSRYPMPVPPPPPPMSLGLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0D1</accession>
    <name>A0A183I0D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040083">
        <property type="protein sequence ID" value="VDP13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0D1"/>
    <dbReference type="WBParaSite" id="OFLC_0001319401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001319401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001319401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001319401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9885" checksum="2A4029219F726CA1" modified="2016-09-07" version="1">MMRRASIIIMTAMENGGNDDDDDNDDNDDNDDNNKCNDYDTAPILSKVLNIYFSHGFFPIKIPLFLVENMPAFYSFVQKLSEKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0G9</accession>
    <name>A0A183I0G9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS13231</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01040101">
        <property type="protein sequence ID" value="VDP13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0G9"/>
    <dbReference type="STRING" id="387005.A0A183I0G9"/>
    <dbReference type="WBParaSite" id="OFLC_0001323201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001323201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001323201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="40"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001323201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44324" checksum="AD8C1984D23D0D89" modified="2016-09-07" version="1">MVNNSEEHLEEQRKLWKKLFKMDQFSSVIRLPREYRHHRWNALHTLGDGAFGEVRLLIDSKNLQTTVAAKCMNANKSGKEEEFFKKLRREAFIMHILHNSEFVIHYIGMRYDEGRIEMFLEYADGGELFDHIEPDNGMPVRKAQGFFRQIIAGLKYIHSMGIVHRDIKPENLLLMKNGQLRICDFGLATIFRHKGVERKLKSRCGTVQYLSPQVLASDYRGEPSDIWSCGIVLVAMLTGELPWEEAVKTSSAFKIWLTKYEWRYWPPWDRLFGAITDLLRKMLDVSEKRRIKIPEIEKHEFFVENIDYEIPNAKAMRGDKNKATETATLPPKTMNVASIDENLSNLKEHNESAEPPIFLEKIVVEDGPKKVKLTSTNVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1E4</accession>
    <name>A0A183I1E4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADPH--cytochrome P450 reductase</fullName>
            <ecNumber evidence="12">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS13556</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">This enzyme is required for electron transfer from NADP to cytochrome P450.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="UZAJ01040263">
        <property type="protein sequence ID" value="VDP14059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1E4"/>
    <dbReference type="STRING" id="387005.A0A183I1E4"/>
    <dbReference type="WBParaSite" id="OFLC_0001355701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001355701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001355701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="11 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="76"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="283"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDP14059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001355701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="675" mass="77804" checksum="2D72A03F86183B40" modified="2016-09-07" version="1">MSMTVVDWLRTRLDIIDLIVLTVLLLTTVYYSWRLWAKKTSNKFTSTVLPSYTSFESSSDRQTSFIARMKSEERKVLIIYGSQTGTAEELAGRLSKDVQNYGQKALLLDPEEMNVEDFEKIKEIPGTLLIMCMATYGEGDPTDNAQEFYQHVLNTNLNLKGVNFAVFGLGNKTYGHFNEIAKYFDQRMEEFGATRIYSLGLGDDDGNLEEDFMRFDKLKACIFRWREGFWSAVTTIFGWEIAETGSIRQYRFEIVEDFSVKLFTGEYGRLGSFEKQRPPFNQKNPFIATISVNRELHGIGSDRSCRHIEFIINGARIRYEAGDHLGVFPTNDPVWVEELGRLLDADMDLRFSLINLDEENRKRNPFPCPCTIRTAFTYYVDISAPIKSNVLKALASFTSAENEKERLLLLSTASEQGLKEYGNYIQKERRSIIDILRAFPSCKPPVDYILELLPRLQPRYYSISSSSKYSHDSLAITVVITKYMIGDRLIKGVCTNFLLQKGEGSKVPIFVRKSSMRLPHRLKTPIIMIGPGTGFAPFRGFLQERNWQKKQGQDIGPMALYYGCRHPEHDYIYEDELKKFIQDGVLSELHTAFSRITAKKIYVQDEIWKNRETVWRAIENGAIICVCGDARNMARDVQNTFMRIFMEIGGKTETEAQKFQKDLEQRRCYQTDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1S3</accession>
    <name>A0A183I1S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TROVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13685</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040334">
        <property type="protein sequence ID" value="VDP14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1S3"/>
    <dbReference type="STRING" id="387005.A0A183I1S3"/>
    <dbReference type="WBParaSite" id="OFLC_0001368601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001368601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001368601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056800">
        <property type="entry name" value="vWA_Ro60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25045">
        <property type="entry name" value="vWA_Ro60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="7">
        <location>
            <begin position="54"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP14393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001368601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="745" mass="85804" checksum="0909C168025F24B1" modified="2016-09-07" version="1">MNIVEYLSSSHTDDPRYCLNIAFAVRTLQQQNESRYFAESGAIVNTCAFLDAKYNRQYRNSSFLVTDIGIAGNQLFPTPTSDDEFVRRFLMLGNCEGIYFARQKVFTCILVPGKGLIILQQILEISQSNYAPKIEPLLIALALCARYKVRDTQSKRKLPWDTEEEPEKLFPDAVCRDIRPVMENTYQKCLQQLALFSVHKVCLTPTHLFMFINYCKVVSKQSGLKKDSNGWGRALRATVIKWYYNQTPDRLAVMVTKYRHRINYSHRDLFCLSHIHPKQSFPPECNYWQHQQDYENIIAYVVKGSEKVRKRRQELFLKRQSKRQHLDLEETERVRQTLEELNLKRTEKKKVSEDVEVTTSTSSRKVADSQVTNALKYIDAFEELQNLTSANIDRAVSLILQYGKQTFILLIVSTGIAVTTSKVSFEKEQIPEELLSSKKVWGALLRRMTLPTMLKNIGRMSGIDLFNEADDSVFNYLSDVLSNITWFFYDDDKNYTDFTRDDPASLVVRRLNDIEKLKQERLHPLAILFAKMNYEHGHEMRGNRVWKPVRSIQKAFDNAFYNCFDAVEVTNKQYLIAVDISDSMDSFVQGTMLACSQAAATLSMALIQHEENVVPLAFSNFLAPLEWDKFMSLGEYLSATKNLIYGKTDCALPMCWAIENAVYVDVFIILTDNDVSVKSMKPSDAIRWYREQMDVPNAKLIVIAMSGKSESLANPSDPNMLVIYGMNPSVPQVIYDFVRDFQPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Y6</accession>
    <name>A0A183I3Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14448</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040864">
        <property type="protein sequence ID" value="VDP17088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Y6"/>
    <dbReference type="STRING" id="387005.A0A183I3Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0001445601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001445601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001445601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP17088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001445601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14514" checksum="0CC46C3580F05F67" modified="2016-09-07" version="1">MEEGEERRGRERKEKRKDEDVLDGEFWHFITKQNRIIFIVSAARAKDASEARQQQPNKIPVVIERFEGEKYLPLLDRCKFLVPDHITIAELMQIVRRFVIEFCTETQVKLFWNFSLFLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I526</accession>
    <name>A0A183I526_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14838</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041267">
        <property type="protein sequence ID" value="VDP19135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I526"/>
    <dbReference type="STRING" id="387005.A0A183I526"/>
    <dbReference type="WBParaSite" id="OFLC_0001484901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001484901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001484901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP19135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001484901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26029" checksum="95DDF7DB019579A3" modified="2016-09-07" version="1">MACQIARGLEYLHLKGCIHRDIATRNCLLSGTIVKLADFGMCRATLVYKIDLSKPQNVRWLAPEVWRSGETRFCTDMFAFAITLWELFTIPYTHPYSAWKAYKVKEKVMAGYRLPSPNDMPESMITIMRRCWDHDPSKRPTAKQAREYLEEIYQNLATASPHTAVLSQGSSKLTASKEDDSSMSTSETSTRLSRERRVIKRGSSSSRSKTSSRSKVPSKIKNYRRASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5K5</accession>
    <name>A0A183I5K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15017</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041489">
        <property type="protein sequence ID" value="VDP20035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5K5"/>
    <dbReference type="WBParaSite" id="OFLC_0001502801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001502801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001502801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001502801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7759" checksum="19F928E076EF2A5A" modified="2016-09-07" version="1">MEQLIAIGGHENEPEFSALMVDDIIVFPSELKWKLMNTVKQIKLKNPTENRFAIKVMTFFFFFSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5U7</accession>
    <name>A0A183I5U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15109</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041624">
        <property type="protein sequence ID" value="VDP20426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5U7"/>
    <dbReference type="WBParaSite" id="OFLC_0001512001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001512001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001512001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001512001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="3938" checksum="1ED26D662352CA20" modified="2016-09-07" version="1">MMLQIKLLVSETGKIVGEARSKFRGIIKLSSLLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6C0</accession>
    <name>A0A183I6C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15281</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041877">
        <property type="protein sequence ID" value="VDP21148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6C0"/>
    <dbReference type="STRING" id="387005.A0A183I6C0"/>
    <dbReference type="WBParaSite" id="OFLC_0001529301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001529301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001529301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001529301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="21556" checksum="76F1A93F88F1DBCE" modified="2016-09-07" version="1">MGDAPPPEGAPAEGAPPAEGPPPAEGAPPAEGAPPAEGAPPAEGAPPEGGAPPEGGAPAPPAGPPTLNIDPPAAQVPAAGGQSVHQVANPSGVRLAFKINEAAEGTDSKVKSKSRLPKFESARRECSFYQKQLCVRIIFWGGQYDGSVLILCGADDILIKHHSEILIIYRYHPDCASLDLVEEMIWNIRLSMFEELVLSKWGKFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6M7</accession>
    <name>A0A183I6M7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15389</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01042052">
        <property type="protein sequence ID" value="VDP21635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6M7"/>
    <dbReference type="STRING" id="387005.A0A183I6M7"/>
    <dbReference type="WBParaSite" id="OFLC_0001540001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001540001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001540001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP21635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001540001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39063" checksum="11D677E1EADDAC08" modified="2016-09-07" version="1">MVFTVALASSSNSSQSNPSKHAEQQMKLYNRYRNLILIFVANEIERLSAWLNPLGEAVGLEDSNIEQWRKSTFPEARTEAKLLRENVRIAWQICPDLATAVQELLVNSPELVTDLPEALSLMLGEGKILEEKMEDLKTLSHILTWAVCDPVMALSLLGARQYPTHPITVQYAVRVLRSYPPDVLLLYIPQLVQALRYDTMGYVAELIMWLAGAARKFYDTEFDLFKNITDISGKIKPFPKGEARKKACLNALAEIHIKTVAYLPSNPEAVVLDIDYKSGTPMQSAAKAPFLARFKVLRCGIQKLEQLGIAAHQQKPTLETDIQFFSRSKDSLICWQAAIFKVGISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6W2</accession>
    <name>A0A183I6W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAB3GAP2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15474</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042207">
        <property type="protein sequence ID" value="VDP22050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6W2"/>
    <dbReference type="STRING" id="387005.A0A183I6W2"/>
    <dbReference type="WBParaSite" id="OFLC_0001548501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001548501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001548501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001548501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20859" checksum="2358FEA64C8A0F13" modified="2016-09-07" version="1">MIELCLDSRLLLVAGQSGQLTLFRFVKTENTHEITVINIPSVFSVLSSNVELAKPSSPKRELKRQGTAISMESNSTDTSEGSTQDGYFPLKVKGGVLRRVAGYQPDLVCMVPWRNVSQPEKITSMALNSAYGIIALGTSASLTLIDLVQYVIICSWPVADLYVQQHSTPILLSQNSTSSQYDVCILEIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Y0</accession>
    <name>A0A183I6Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding alpha-beta plait domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15492</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042246">
        <property type="protein sequence ID" value="VDP22165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Y0"/>
    <dbReference type="STRING" id="387005.A0A183I6Y0"/>
    <dbReference type="WBParaSite" id="OFLC_0001550301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001550301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001550301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001550301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18000" checksum="DFEBE0E33D25FECF" modified="2016-09-07" version="1">MRVPGPNTFMSSNYNMPLPRYNASCGSLNMRANRPGMFPGRSPFSPYRGGPPFGGAPLRGENRWRNSEPGNGHVNNSRHDEWDNNAMVPSSSHEEYAQLESSKIGKRKTERTEMDDSSNEPVTSTTHDDESATVSGTVEVLASEAKLLNNASIVPNNDDLKVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I728</accession>
    <name>A0A183I728_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042328">
        <property type="protein sequence ID" value="VDP22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I728"/>
    <dbReference type="WBParaSite" id="OFLC_0001555301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001555301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001555301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001555301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11656" checksum="F157C39ABE5C64AC" modified="2016-09-07" version="1">MCPVQHLSRTPSPTPRSVSHCLSRCESGGSTVEHEIRLTPTPKHRNSGKTCKCDVTAQRGNGSRYCGEYSDIVKDSANQINRTGYRFRRRIHFSHICWGKKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I732</accession>
    <name>A0A183I732_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15544</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042335">
        <property type="protein sequence ID" value="VDP22468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I732"/>
    <dbReference type="STRING" id="387005.A0A183I732"/>
    <dbReference type="WBParaSite" id="OFLC_0001555701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001555701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001555701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP22468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001555701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15342" checksum="733FD05971249C59" modified="2016-09-07" version="1">MPILQALLETPQKLFALVLTPTRELAFQIGEQFEALGASIGILIAVIVGGVDMVTQALALAKRPHVIVATPGRLVDHLENTKGFNLRALKYLVMDEADRILNMDFEVELEKILKVIPKERITYLYSATMTKKVSLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I733</accession>
    <name>A0A183I733_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15546</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042338">
        <property type="protein sequence ID" value="VDP22481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I733"/>
    <dbReference type="STRING" id="387005.A0A183I733"/>
    <dbReference type="WBParaSite" id="OFLC_0001555801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001555801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001555801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP22481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001555801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="6677" checksum="1C8C519445C4909E" modified="2016-09-07" version="1">MPGPSGPDGPDGDKGPIGEPGITGPRGRMGLPGKQGERGPKGLPGQPGMPGPQGKRGIKGMVGPQGKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7H8</accession>
    <name>A0A183I7H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUGBP Elav-like family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15690</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042631">
        <property type="protein sequence ID" value="VDP23247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7H8"/>
    <dbReference type="STRING" id="387005.A0A183I7H8"/>
    <dbReference type="WBParaSite" id="OFLC_0001570301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001570301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001570301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001570301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="17738" checksum="7015D09970DF851A" modified="2016-09-07" version="1">MIDAYITQKQSQGRATTTISRSPTTSSLHLQLSSGNTGNGASGLMAPSMAVAAAAAAAAGGTMPSLQGSLPSALPGVLGSSLPLAPNLPGATASLTNGTSEAAAQAAMFAALQNAQQNAATALPNGSLSSAPYLLPSAAAVSAQPHPLSAITSQTQSVYSSQRLFDPNMAAVLQQMQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7I4</accession>
    <name>A0A183I7I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15696</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042650">
        <property type="protein sequence ID" value="VDP23288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7I4"/>
    <dbReference type="STRING" id="387005.A0A183I7I4"/>
    <dbReference type="WBParaSite" id="OFLC_0001570901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001570901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001570901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001570901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18123" checksum="DE309F81EB80674B" modified="2016-09-07" version="1">MADSFSMAVANDDFDRLQGYARVFCELSESLLECMIREPGRDLGDFQSIELLLLLAGYHDYNLVEMTFNIWYRLSEHLYERNDDELNAQFKPYIERYIMALYKHCRFDTDQEDIPDENDDFIEFRGQVSDTLKDVVFIVGTDRCIQSVCIFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7S4</accession>
    <name>A0A183I7S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15786</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042889">
        <property type="protein sequence ID" value="VDP23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7S4"/>
    <dbReference type="STRING" id="387005.A0A183I7S4"/>
    <dbReference type="WBParaSite" id="OFLC_0001579901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001579901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001579901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052804">
        <property type="entry name" value="UEC_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359:SF2">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001579901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8255" checksum="25895DF8EDC42C4F" modified="2016-09-07" version="1">MVDFVDGDSIRYLPCMHCYHKKCVDDWLMRSFSCPSCMEPVDSAMLSSFAAHTVRGLEALACSPATSGIHDNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I893</accession>
    <name>A0A183I893_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15955</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043358">
        <property type="protein sequence ID" value="VDP25313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I893"/>
    <dbReference type="STRING" id="387005.A0A183I893"/>
    <dbReference type="WBParaSite" id="OFLC_0001596801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001596801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001596801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF53">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP25313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001596801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18083" checksum="CC6B2928D9E63D49" modified="2016-09-07" version="1">MLSTLFAKSQMIRKGIQSFLFRRPWTQDKIPVIRIATYTLLLCLFHFVCWTPYWISVLYLLYLEIFPPPEFQMPTSSFIYFMYGVHALPYINSASNFILYGLLNRQLNQSYSKKHSKVSRKAQLHLIQQRVDFIDDSAKRKLNNDPSSCITFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UD88</accession>
    <name>A0A3P7UD88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000690">
        <property type="protein sequence ID" value="VDO29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1U8"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF73">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="889" mass="102698" checksum="19F159E09634F177" modified="2026-01-28" version="1">MGSLYRSEQMRFCQMIVQKDAAFSCVAELGKHPYVQFKDLNADVNPFQRMYLRDIQRFEELERKLRFLDAQIRKDDIEVNDDVSTDGTYEVLAPHELNQLEGTLVDLERDVIDMNSNNILLKQSYLELKEWEAILEKTDHFFEEGISDVAMHEIEAMEEESALALKRAKEPIGFLAGIINRDRVNAFEKVLWRACHKTAFVRTTDIEEELENPDSGEMCTKSVFLVFYKGDRLRIIIERVCEGFKAKIYNNCPKNSKDRHAAARDVKARISDMRTVLGQTQEHRYKVLQAASSSVKQWQKEVRMQKSVYYTLNLFTFDAIGKFFIAECWVPYADLENVRLALEEGVRKSGSSVRPVLNLLETTEEPPTYNRVNKFTRVFQAIVDSYGTASYLEINPAPYTIITFPFLFSCMFGDLGHGILMLLAGLWMVLREKNLEARNIKDEVILNTFYGGRYIILLMGIFSVHAGFLYNDVFAKSFNLFGSKWRNPFPNTEIESWDSESIRLHKEILIDLPPSRSYMHDHGPYWFGVDPIWNLAENRLNFSNSLKMKLSVILGIAQMTFGVFLSLLNYIYFKSKIEIFTVFIPQILFMFCIFIYLCAQIIVKWLFFWVREEYIFGLLYPGSSCAPSLLIGLISMFMFKDRPLGFVDEMEIISVNDGHVTYANWPNCYLSQWYPGQANEFQSTFEAILVIIAVICVPIMLFGKPIHFLLHHKKKNVVSDNSVVWQNQENDKAEITLNENGSSLNKRNWEETTSNNEYEEESFADVMVHQAIHTIEYVLGCVSHTASYLRLWALSLAHAQLSEVLWEMVLVQAFGISGIAGYFTAYFIFFAFGILTVSILVLMEGLSAFLHALRLHWVEFQSKFYLGLGYPFVPFYFKDVLLKASAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V7G0</accession>
    <name>A0A3P7V7G0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000932">
        <property type="protein sequence ID" value="VDO30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V7G0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09339">
        <property type="entry name" value="LIM4_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF62">
        <property type="entry name" value="LEUPAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="251" mass="28924" checksum="D5F7377EBF28D58B" modified="2019-02-13" version="1">MKGEWGRGRDSDFYLLLLGQSNVNKQSQVVIALGKMWHPEHYVCCQCGEELGHRNFFERGGKAYCENDYHDMFSPRCAYCNGPIKDRCVTALGKTFHAEHFVCAECGRQFGEEGFHEKNGQPYCKMDFFRMFAPKCNGCKTPIKMHFITALGTHWHPECFICQECGKPFETGSFYEHGNVPLCELHYHEKRGSLCATCQKPINGRCVSAVGQKFHPEHFCCSYCRKQLNKGTFKEVDRKPFCHKCYQTTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VDU5</accession>
    <name>A0A3P7VDU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000777">
        <property type="protein sequence ID" value="VDO30063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H274"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="332" mass="37051" checksum="96E73B2B6002BDE7" modified="2026-01-28" version="1">MFHFAGGSTEGTIPHPSNTQISKVQFSPDDNGQLLAVSSWEGTVRIYHFPAGPVTALEKRVYTHAKPVLTCTFFSENDIASGGLDNLIKTYNMETGVEFVLGHHEAPVRCLEYCKEHNLVASGGWDSAMMLWDVRSKSSAGFGNNGDKVYAMDVHGNRVLVGTKDRKIIVWDVRNLGEPEQIRDSPLKFQTRAVKCFPTGEAFVVASIEGRVAVEYFDMSAEVQKNKYAFKCHREKDESGTEMIYPVNCIDFHPIHNTFVTGGSDALVNIWDPFNRKRICQLHNIMSVSFNSTGTQLAIAASYMNELKERPNPEPESTVVVRKITDVEARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W3Y4</accession>
    <name>A0A3P7W3Y4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase family 2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009555">
        <property type="protein sequence ID" value="VDO55680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W3Y4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="2">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO55680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="155" mass="18202" checksum="9692B63C1EDEDCB4" modified="2019-02-13" version="1">MILAAKNLQADLLDLICVNKYFGWYTDIGYLDTVNQSWIYEMSNWKLKYNKPIIVSEYGAEALPGLNQEPSRTFSEQYQQELLEQTHHAFDVLRKNHIITGEMIWNLADFMTADGMTRAVGNHKGMLTRTRQPKMAAYILKKRYKNLEKEMKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X714</accession>
    <name>A0A3P7X714_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000075">
        <property type="protein sequence ID" value="VDO25192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYF7"/>
    <dbReference type="OrthoDB" id="9984614at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="417" mass="46361" checksum="C530497581C7A9C3" modified="2026-01-28" version="1">MSPASVDSGFDSSFPSSPDCSLDSSTGINGAEMTKYYKDSHFKRRRQTVASLSVVSQCPLSVCQPTCSSLSSPISRTSSDISTFSTNSLISTDTKTDENFCLDACLLKKTASLTSSSSSLQLAVDIPTNQDSEVSSTARLGCSTIPSFSGSTSSEVNELIFRVRCHWKSCTEWFACDNDLYDHVVKAHLELLRPSIDLDGNSNSSSGNSGSQSHTVGRLKNLMCQWGSCKMGLSRGDFQKQFIWLEEHFTTRHAGKAQPYMCLIEGCSLRFTLKRSLEEHLRTGHEKAKAKRPHTEEGELSRIKSCYQWTPVPYYIPNEKNDFLDHATEEWIVMRLRQYEQTSDACFIPREPTTPRGGAAYRKRRRILTFAIEPLKITPKVISDTMGLSDAKSLIKSAFISAKSYTNSVNRTVTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XUJ9</accession>
    <name>A0A3P7XUJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001394">
        <property type="protein sequence ID" value="VDO32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H4L7"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="199" mass="23462" checksum="0BF9F5D8DFE012B3" modified="2026-01-28" version="1">MNYKGVLLEMTRWRESLDQMLTIVESIKRNTEYNSWDERMRNLLDYVEQLDREATIETEALKEMQDQGQGSNADADISRDSFRKRIEEIGWEQPNKQGEAADRIKTLRNIERANTSSTVEVERIYYSKKDPYTKQDIKDPVQNMICKHVYDRESVLANIRECKKRRLLCQCPVSGCPNKKLLTMSDMVAFPKFYDCLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ADZ7</accession>
    <name>A0A3P8ADZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039923">
        <property type="protein sequence ID" value="VDP12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8ADZ7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="389" mass="45062" checksum="C78607F2F44626A7" modified="2019-02-13" version="1">MINVNTSGFVENQSISEERQAAEEAIEENEEERIPHESFYSGILEETFLPEKFISNDRNTRFISSSASPTKMSVTPNRHLRGCIDVFLFILCLALVILQFGLLDFYYLTVLKDNIWYTWIGADSLVIVILIWLLVIVVRNNQQHMEDACSADAKVKYTWIGWFLYSVVLAGKVAVCFRLFYTQLPPVKTDSHDKILDDHLFRLGLSLSAPIFILLLESHHYTTVNSNRQLYLIYLMTSITFDLIDTVCFLDLLWQSFKNSWDLPFWLDLAILLLACINLILPVFTLIRLRFGRRLPRFALFSEKIWSLIYVLMVNAPYLGIRIYLYVLLEISANGKHYDASILMIKNVAMIYLAVRDVWTRLQYWRHKKNISGSRGELTAPGATNDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B8W7</accession>
    <name>A0A3P8B8W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014133">
        <property type="protein sequence ID" value="VDO69205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HSS2"/>
    <dbReference type="OrthoDB" id="5848645at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="143" mass="15539" checksum="F692D45C633C594F" modified="2026-01-28" version="1">MASVWKPRCLMQNVARTGAVPNINDQDVFPTFEAAEKIEKLKKDDEKKRRNDGFVTVTSDRDTSGAWTTKGTSSNTWQRAGSGGGMTSSNADRTALLSTVRQVTSGGAPNPVPHPQPLQTKNPNAYVPPSRRRAQANVTKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CFA9</accession>
    <name>A0A3P8CFA9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018902">
        <property type="protein sequence ID" value="VDO83585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CFA9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16138" checksum="8BC867301876ACB5" modified="2019-02-13" version="1">MARKHIYQYEAQPEQTEPLDLSKVGEKQKGPFGSSVLKESEEEVANLRILSIQEENEKKKLNYDEREEKQNTAVKMYSCLESGKILKTLKCLKSHSKVHMTRNSIFVTDAESISFDYHICYPICILTPERSRSFVKYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EQD3</accession>
    <name>A0A3P8EQD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040286">
        <property type="protein sequence ID" value="VDP14179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8EQD3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="162" mass="17888" checksum="1F87A09B45A2F5AE" modified="2019-02-13" version="1">MQGWSSPFPLSPHEHDSPKTAITETAEILKTGNSDRNENYINTQATRQPSVSWIEKSAKMGLSTSQTSSSTTPGRGIFERDCDLPGWLNANGNQTDHYDVEVKPSIQTNRNSPSDILVKAHGCIKLALQAPTPITFNLTGLTASREIRVRKLFVNGQEYVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXS3</accession>
    <name>A0A183GXS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS33</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endomembrane system</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000007">
        <property type="protein sequence ID" value="VDO24272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXS3"/>
    <dbReference type="STRING" id="387005.A0A183GXS3"/>
    <dbReference type="WBParaSite" id="OFLC_0000003201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000003201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000003201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="17">
        <location>
            <begin position="130"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDO24272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000003201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44141" checksum="9FFCE05970A9FCF5" modified="2016-09-07" version="1">MRHSVGQRDKINRRVNADGELRINEENKNQKKHVNDDDELPGNSDPDTIFKLGEIGNFEPKEIQAQPGNYGEMGKPVLVDKTLPEVKQAMREYGFNTYVSDMISLNRSVPDVRMDECKYWHYPEDLPTASIVIAFHNEGWTPLLRTVHSVLLRSPPQLIREIIMVDDFSDKEHLKGRLDVYLKQFNGKVKLIRNAEREGLIRTRSIGAKEAVGDVVIFLDAHCEVNINWLPPLLAPIRQNRKVMTVPVIDGIDKDDWSYRIVYSSVDRHYRGIFEWGLLYKETEISAQELRRRKYSSEPFRSPTHAGGLFAINKKWFEELGYYDPGLQIWGGEQYELSFKIWQCGGGILFVPCSHVGHVYRSHMPYGFGKLSGKPVISTVITHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY06</accession>
    <name>A0A183GY06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claudin-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000028">
        <property type="protein sequence ID" value="VDO24605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY06"/>
    <dbReference type="WBParaSite" id="OFLC_0000011501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000011501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000011501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000011501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11146" checksum="3179781F17E255BA" modified="2016-09-07" version="1">MGERGAISLTNCSITASLFEVVFAGAGMIAWMLVCGIGGTISQRTIIETGEHFGWIAACAGIIVSLYLAIMALFCLNLMVEKVFSSDRNNKYISAHYPHNSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY92</accession>
    <name>A0A183GY92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000054">
        <property type="protein sequence ID" value="VDO24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY92"/>
    <dbReference type="STRING" id="387005.A0A183GY92"/>
    <dbReference type="WBParaSite" id="OFLC_0000020101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000020101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000020101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000020101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8095" checksum="55DC94C2FEA86B0A" modified="2016-09-07" version="1">MGNKSCAVLCSTTWCNTVLFRVQYNMTATSNGSATNTTAVTALSHQAQYCGPYKIEKTLGKGQTVPIDRLTNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZT2</accession>
    <name>A0A183GZT2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">39S ribosomal protein L16, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS742</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000280">
        <property type="protein sequence ID" value="VDO26903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZT2"/>
    <dbReference type="STRING" id="387005.A0A183GZT2"/>
    <dbReference type="WBParaSite" id="OFLC_0000074101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000074101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000074101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18493">
        <property type="entry name" value="BACK_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18292">
        <property type="entry name" value="BTB_POZ_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF47">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000074101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="540" mass="62611" checksum="61DFDA78C49D5D6A" modified="2016-09-07" version="1">MDCFADDREALNDFTKYYNNTHLSDVALLVGDEIYAAHRIILTKSSEVFDQMLSKKWNGDKKELELVEDLPCQSVFAAFLRFLYCNHVFLHPENALPILILADKYNVNSLKKVCIDYAVNNILPELSTRELFHVWFSYATKAFHQPLISACIKVLAWHFEEMIMSEEWEKEWLSVDRDQLIELLRSNDLVLPNEFRLWEAVQKWLTASSHPERRGNTASPLLASIIPYIKLKSKYRRVFKGRIKGSTKDGSTLLWLKSYRSKEAVRRVISRTLKCSGRVWIRIFPDIPVSKKAADVRMGKGKGSVEFRVFKAKPGRVLFEINGGVSMHLAKLAFEKAIAKLPVKSDELTIVERSPLVEIHPKLFHPQILLAYKFQALPLGSRASCKEFTGSQFILRNYTDIRWDKRITIRADELRRENGYDRSIDQAYNITTRSSTFPMQAWNWKLKLTSQLVPNSHDELRMFLVSDDIDQPRSVEYLVQIVDERKVLRSFSSKRNFTKTRYSADIEIEKKVDLGELYTDNSPLLVNGELHLQITLKPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZU2</accession>
    <name>A0A183GZU2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS751</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000286">
        <property type="protein sequence ID" value="VDO26933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZU2"/>
    <dbReference type="STRING" id="387005.A0A183GZU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000075101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000075101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000075101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000075101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="82529" checksum="AAC24367F9797B4A" modified="2016-09-07" version="1">MPPFLVTGDFVYIPAVLFVSYFGSKGNRVKWIGVGTSITAISHLLIFSSNFLFPVERQILNYTALQACVLTQFQFYVHSSSILRLNKYIKGTSCNHKRLLPPDELFTPKAKFEQFFDYEPIKDRIDESVKDDFLKKIMLMNNYSLHDVMSSWNSGYSGRSKEVAVVNDNYTLDEALLSKIIQKMHKVIDGNTGSSDIREVKSLLQEYVAERINETSGDLDKVRNSARAPFAYCSKLINEMRQIIKTGKCGKKSLHVRPIIVLFVGLILFGIGRCMPWSLGVPLIDDTFSKKNLPISVAGMNFIRILGPVCGFLIGSLCSSFYYTLKPPPSLTAKDPTWIGAWWMGFLFIGLLLIGPSIALYFFPLRQKSAIVPQSGTVNSDNDAEQKEMPMFDKYRHNDSVESVSIYIKFRALYKAYVELLHSKIFVALLIARTFDLLAVRGYMVFLPKYLEIQFGIPQYNVHILMASFGIFGLAAGAISGGIIVRRQKFSGRGTAIFLVIFSVVNIALFFSKGLFGCYSTTSQVGVNGRSTNYNYTQLCNANCGCQSAPLYPICDKSGYAFFSPCHAGCRNVRITDVKTHELEFSSCQCKPEEVLSRKNCQDDCNLKAMFFFILMIIGSFAGGNCIVPGILLILRSVPSIHRSIALGFQGFMISLFASLPSPFIWGTIVDTTCLVWNYTCPENKGACVIYDPILLRQRLHFTYVGIRLISAIADLYVIKHADSINIMDEPNDNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0F2</accession>
    <name>A0A183H0F2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS962</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000399">
        <property type="protein sequence ID" value="VDO27727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0F2"/>
    <dbReference type="STRING" id="387005.A0A183H0F2"/>
    <dbReference type="WBParaSite" id="OFLC_0000096101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000096101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000096101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000124">
        <property type="entry name" value="STIP1 homology and U box-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041312">
        <property type="entry name" value="CHIP_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18391">
        <property type="entry name" value="CHIP_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="223"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO27727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000096101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35654" checksum="8B88A432B7950FA4" modified="2016-09-07" version="1">MSAHVAEELKETGNCFYQQHRYEDAISAYSRAIINNPVIPTYFTNRALCYMQTMQWEKAEDDCKKALDLDRKNVKVTCYYFFVIRKANFFLGRTCVQLGHFDEALKVLTRANDLAHNQKLNFGDEITAQIRIAKKEIFRREEEKRIKQEIELQAYLNGLIDGDLARKLQKLKEKKESGENNEVITEGVDLESEEMALKMEAQSSKDKLNNLFAQVDEKRKKREVPDYLCGKISFEMLRDPVITPSGITYDRADIKEHLQRVGHFDPVTRAPLTADQLIPNLAMKEVYFIEIFLFLWLFKYLLTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0U6</accession>
    <name>A0A183H0U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1106</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000475">
        <property type="protein sequence ID" value="VDO28267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0U6"/>
    <dbReference type="STRING" id="387005.A0A183H0U6"/>
    <dbReference type="WBParaSite" id="OFLC_0000110501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000110501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000110501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552326" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000110501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20594" checksum="83D9A877CB865660" modified="2016-09-07" version="1">MSFLVFILSITVAVAVKNNSDPGYDILKFMEQFQANLRDPINLSEELICNCSYSGCDTEIVRFLGSTYTGLCRSTSGICYKRLLPDRSIILSCLSKDASPDLHCRVKQPMNDGSMMQCCWNYSFCNGALDLNLVNDYSSVRFHSILLFIRFLCSLFSIIEAVMYIVKSSVNTLFDYRDIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1D2</accession>
    <name>A0A183H1D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000585">
        <property type="protein sequence ID" value="VDO28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1D2"/>
    <dbReference type="STRING" id="387005.A0A183H1D2"/>
    <dbReference type="WBParaSite" id="OFLC_0000129101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000129101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000129101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000129101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11351" checksum="1A2AD889587EB91A" modified="2016-09-07" version="1">MIRGEKEEEDTFLIKTKISKNYLPVVRKRRSLTRSECSESPKLPDDVHVEMDCLGTKILNSSSTGIVYFYFISQSVRTRWQSRRCEDPSSRILRCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1F4</accession>
    <name>A0A183H1F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1314</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000596">
        <property type="protein sequence ID" value="VDO29087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1F4"/>
    <dbReference type="STRING" id="387005.A0A183H1F4"/>
    <dbReference type="WBParaSite" id="OFLC_0000131301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000131301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000131301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000131301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10425" checksum="BF0709202DB96DBD" modified="2016-09-07" version="1">MRCKSENVVLETLAHTGSTKPCDRCDRCFGQQTNLDRHTKKHESNTALTLATTTTGSMAVHREPLTVPIRTAPVALPFSAQSLFSQLTPSVQPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Q8</accession>
    <name>A0A183H1Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1418</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000661">
        <property type="protein sequence ID" value="VDO29460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Q8"/>
    <dbReference type="STRING" id="387005.A0A183H1Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0000141701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000141701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000141701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO29460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000141701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29362" checksum="E1AB510485296B0D" modified="2016-09-07" version="1">MSSTEFDSYPLVVALGYYMTVFVVAEYETAGTLSFYLLMEVIATAQMCTCVYENALIIRHYGLLGFFFAVTLLIFSGGIMNREAYVSPLIPIELYYKGTLSAEKLLTIIAGEMIGGYSAYAFARHLWYWSLNLSADHAFFLENPACKLTYKVGTHQVPFIFVPSFEVIGCFLMRYILRRIPPNLKIYMVPTVISSFLTFASLFIGVPGLNPTIVSSRLQGCEGLSTIWFILTYWICPIIGWMLSVFMDKPEIAVTEKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H282</accession>
    <name>A0A183H282_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1592</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000780">
        <property type="protein sequence ID" value="VDO30090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H282"/>
    <dbReference type="STRING" id="387005.A0A183H282"/>
    <dbReference type="WBParaSite" id="OFLC_0000159101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000159101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000159101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="8">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO30090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000159101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17050" checksum="962DD5684E42F375" modified="2016-09-07" version="1">MPWGNRCCVYDLAFKPDGSELLVAADTKVLIYDGTDGTLLQSLKGHKDLVYAVAFSYNGENFASGSADRSVIIWTEQHEGTLKYIHNEAVQCLAFSPITCFLLSCAISDFGIWTQLEKSVSKQRTSSRCVCCSWSCDGQFYAIGMFDGTVSLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H302</accession>
    <name>A0A183H302_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1862</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000969">
        <property type="protein sequence ID" value="VDO31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H302"/>
    <dbReference type="WBParaSite" id="OFLC_0000186101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000186101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000186101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000211">
        <property type="entry name" value="Obscurin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="466"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="566"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="666"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="760"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="856"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1359"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1359"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1387"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1442"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1466"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1596"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000186101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1612" mass="182938" checksum="2FD20B53F354CB08" modified="2016-09-07" version="1">MKKSKAPKKLIKEKAEEVEKIQQEKPISSSLETEKLKAKLEMDDKIERPKSKEEKDEEDVNRKLDLEQGEKSANKESEEQKSVKDKEVKSKKKITGKKVTKKTLQKPEVKEETEQKSIEEDRKQIEDVYSEEKHAKEEVAEFKDEVEEIGRSGDVDVTAVIPQLEETTKISPDNEATSIRRARKRSSIFALPPDQEILAFRSDTVKIECEVFDEDDEINWLINGKPIKDDKRCSVVVDGYLRILQIDKVIPEDSGTIITANLPLQSAESYLIVEDIPVEIIEKLPHKITGKMDDFVKLSITVSHPNQNFQWFFNNEQLIENNNLYEVIVEDNVYSLLIKNLSYDQAGRYSVKVGSAETSTILTVEGVPVLHEVETIVTAVDLETQDNLMLAIPFKAVPEPTVECFLNNEKIPSTSKIQIDIFNDKVCFCKRKVDKSDAGEYIIKIKNDYGEVSQTFSVNIKDKPGAPENAHITDIDSSSARVHWDAPSDDGGSAITAYILERKEASKRAYHRVAQVSSEEMEYYMDDLKMDTPYMIRIAAVNKYGIGEYLECDSFQTCLPFEAPSVTHPPTIHNVTDQSCTLKWPKVTDDGGSPIYSYDIFLRKDKSDWIKINDELIFTEHFTVPNIEVGPTYEFKIEATNEAGFTSQSNIPSDPLTISKTAELPVLSLPTVEVISEDAVRVQWNEITDENCNVTSYLIRYKSEQASLWSEKEINHSPAEIIGLKEGLSYLFKIAPKSGPTVGEFSEETIPIRVVAAKKPEITKSIKDVSVSRKSELKLECHAIGEPAPQYIWYKDGEEIIPPNENIEIVNQGFISILLIHHASTADAGLYRCEVVNDLGSVDSEATVTVTEIRAHFVSSFPEYLEIDEGEEIGFSCELSDPDASVIWFKDGKLLSSDDRIMIKEDGIERKLTIKNTVPEDSGKYVCSTADNKTHSRAELIVKEELPQIKRGPQDQVVSESGITVVLTCETTKPVTAVKWFKNEKEIWSRQQKFSIDVKETIATLTIMNFELSDCAEYRAALREDEKSAPAKVELKIAPTIKLSKDLPNNVLKLHCGTDFDIEFDYGGFPEVDIKMTLNDKPLDKVRSRIHTYDNKLSLRLKNVIQEDSGILKIMVENELGHASEEIQLDVINVPSKPLHLTAFNITSHSVMLKWEKAEDNGSPITNYIIERKTADINRWRNVGKCKSKQHEFLADDLYPNESYSFRIVAVNEVGEGAPSSVVDIVTLNESTELDISTEETAKYLSVPNRTEATLVEDSQTILITWEIVEEAEDYIVERSKLENDWEQIGVTVEPKFEDSHDKSSSYKYRIIAKKGDQLSNPSSEAKIMIVPVQKEENVEQQGSDTTEMLQEVPEIIEIKQQEVKEPESEISDDQAKKGKAAKKFAKKEDKQELKSSDDTVDVIEKEESKSEEKEITTQEKAERKPKAGKKKPEKEQEEDIEVGRKLENEFESSEKLEKSGEKVQPKKIIKKKALEKKESPKDEVEIAKDFKKAETEKQPEGELEKETEKYKIKSDEEKIESVEKLDVEKGVGEALEEKRLEKKSEAKPKKKTEAEQKIESLETVKVEPEKDSEKKIEEKEKVESTKKKKTTSKQKPKEKMEQKLEKSISQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H350</accession>
    <name>A0A183H350_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001008">
        <property type="protein sequence ID" value="VDO31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H350"/>
    <dbReference type="WBParaSite" id="OFLC_0000190901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000190901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000190901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000190901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8449" checksum="0E521880109C41A2" modified="2016-09-07" version="1">MHTHDDALQICRSPYRLYRPYQFEVPQATIPINSTALYRTPNLDILSEINRRSRRLERIVSYQKVLTITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Q0</accession>
    <name>A0A183H3Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2110</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001148">
        <property type="protein sequence ID" value="VDO31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Q0"/>
    <dbReference type="STRING" id="387005.A0A183H3Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0000210901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000210901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000210901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16504">
        <property type="entry name" value="RING-HC_COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000210901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27522" checksum="9C2F13CDC99C0503" modified="2016-09-07" version="1">MSAGRYTRKRPVAQSITEDETIEDSSRNVNDPLEHCTSSSLSSESSAHSTSNYGHLSSTSLKSFYDCPICFQLFREPYSTLCGHSFCRECISAHLERSLRCPVCSRDLDPRSGPIVFPNFTAASIVDAIRRNMKTARSLAAASAGFSRGRNDGLELTSEKLIDLALNADARFLDHFMDLLKKRREQISNNITRRKNMLLNEFIDEMITQREEKLKQLQNELLILRNDKASIQVTYTDALSKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3V2</accession>
    <name>A0A183H3V2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001184">
        <property type="protein sequence ID" value="VDO32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3V2"/>
    <dbReference type="STRING" id="387005.A0A183H3V2"/>
    <dbReference type="WBParaSite" id="OFLC_0000216101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000216101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000216101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000216101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5709" checksum="69A043B4FDA638B1" modified="2016-09-07" version="1">MIAEDGIYILKINSVDRTWNGNLICEAENAVGTTRTQSIIHVQSIDYLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H457</accession>
    <name>A0A183H457_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2267</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001266">
        <property type="protein sequence ID" value="VDO32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H457"/>
    <dbReference type="STRING" id="387005.A0A183H457"/>
    <dbReference type="WBParaSite" id="OFLC_0000226601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000226601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000226601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000226601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16951" checksum="8B9ECE9211349E46" modified="2016-09-07" version="1">MAPCPQPSSTATPIFLIPFALRTSGCNAIREQGSDSAPVRSIAFTIIDRRCTNSYNKIATTEELDVNSLGLQAALRKVENSIPDGSLLVTNGISAIRQVLHPLALRLSFRLSPLFHKFIDISRFEALPLDENCSLKDELNLIRDRIHYLCKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H563</accession>
    <name>A0A183H563_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2625</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001545">
        <property type="protein sequence ID" value="VDO33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H563"/>
    <dbReference type="STRING" id="387005.A0A183H563"/>
    <dbReference type="WBParaSite" id="OFLC_0000262201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000262201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000262201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000262201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40974" checksum="5B44898A0BBAFFF8" modified="2016-09-07" version="1">MAQRQANEALKKGKVSRSDGRRREKKIVELEKDLRMERQKYEERVMQIVKENEQLKLALAEEEKANEKLRMDLETFQHLETAMNEQKKRERQEIHADQPRTSATNLMQQINENELRYDGAVSIRLTVKRRQQWQECFAVFSPAGLFFYLTQNDRQPFQTIQADNLCHARHVSAADVRCAGENQLPRIFQILYGTEENSSSRRSSMADLSSLSGSREEKLDKALWNRHDLVELTFHMPTNCDLCVKPLSNLLRPPPAFECRRCRMRFHRDHLGVETIPQCRQTVDAREMLIMAPSAEICEAWVQHLKRFLDYKHAQKTGTLLPRSGSSMKVSTKSANVPRSATLPNNSLISPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6N2</accession>
    <name>A0A183H6N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 55 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3144</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002012">
        <property type="protein sequence ID" value="VDO35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6N2"/>
    <dbReference type="STRING" id="387005.A0A183H6N2"/>
    <dbReference type="WBParaSite" id="OFLC_0000314301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000314301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000314301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="1">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000314301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20180" checksum="50810B10BC650E5E" modified="2016-09-07" version="1">MEDPDVPNNAIFIKKVVDFRPKGQITHLCSSNGEILLVIGARQLLHYSLKSTTQQIDVVLPLLMHDRIAYIHLSPNGHHAIISTTGADNFYLNLKHDSAKQLKKLKGHVISSVGWNMEISTDNETGFIVLGTTKGFLFESSIISNGTVTYVRELTNNLSGVKDLSVTGIEMCQCEDENQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7K1</accession>
    <name>A0A183H7K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002318">
        <property type="protein sequence ID" value="VDO36582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7K1"/>
    <dbReference type="STRING" id="387005.A0A183H7K1"/>
    <dbReference type="WBParaSite" id="OFLC_0000346201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000346201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000346201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000346201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11435" checksum="E9C9A07BF33492B2" modified="2016-09-07" version="1">MGAKSNGLNGKKGRGRFVFFKVPEYYPLEVNSALRSNNICTKYSLWQVAYGAAAFPPQSISGAQGTTDPNASVAVAATYQQYDPAALAQYQQKLFHSLPTEQGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H851</accession>
    <name>A0A183H851_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAM91_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002532">
        <property type="protein sequence ID" value="VDO37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H851"/>
    <dbReference type="STRING" id="387005.A0A183H851"/>
    <dbReference type="WBParaSite" id="OFLC_0000366201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000366201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000366201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000366201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38354" checksum="0620422A5E18F716" modified="2016-09-07" version="1">MLNFIDYMTDKDVDQYIRQNIVWSKLPQEIRIVLGNSQREYDKLVLEYSIKNQLRYKGNIVKYVKKNEETYYDILLKYSETHLMLYPYHLSNIVVRELRMTPFSYYINIMTNLMNAEKSYDSLPNFTAADAVRLLGIGRNQYIELMNQNRCNRKLFRKNKSLRELLPAKPVAINIEPWWLVAPGSILESDVKLLNKDEKDLLDMLIDEGAQLVGTLDAKLVQKLYNRGLAYLEVPVNDDDYIYVPTLDGFVMNRVLGDYFENLLYQIFIAIDEQTTVRELSETLNIDLQLVKNAISVFCRLGFAKKRITGLENLALHVTWASHMIIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Y7</accession>
    <name>A0A183H9Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4298</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003204">
        <property type="protein sequence ID" value="VDO39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Y7"/>
    <dbReference type="STRING" id="387005.A0A183H9Y7"/>
    <dbReference type="WBParaSite" id="OFLC_0000429801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000429801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000429801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000429801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6952" checksum="9F95C667044B0657" modified="2016-09-07" version="1">MDKSFESFHFVDRSIGLGAGMGLPVSVLSTIDQAIPSQQPPRFDDLTDAHHDPQYWRTNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBG6</accession>
    <name>A0A183HBG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4828</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003865">
        <property type="protein sequence ID" value="VDO41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBG6"/>
    <dbReference type="WBParaSite" id="OFLC_0000482701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000482701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000482701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000482701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10891" checksum="69A77179248C7FD7" modified="2016-09-07" version="1">MLIKSAFIYTCSFPKVIKLETARISDGNTDVWKHNGIYNQLALLEQAVQKNLESAFNNGVMAANIAYGNLILFASEVSLRSSSREHKSLLVDISVDGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBJ5</accession>
    <name>A0A183HBJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003896">
        <property type="protein sequence ID" value="VDO41281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBJ5"/>
    <dbReference type="STRING" id="387005.A0A183HBJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000485601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000485601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000485601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000485601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5610" checksum="A756F54D0BBE1892" modified="2016-09-07" version="1">MGEIGNQRHVEDGFGTRSLASLRSSTGSAVFKDHRSSIRFLQQKFLFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBP3</accession>
    <name>A0A183HBP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retrotransposon gag protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4905</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003964">
        <property type="protein sequence ID" value="VDO41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBP3"/>
    <dbReference type="STRING" id="387005.A0A183HBP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000490401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000490401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000490401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000490401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33411" checksum="CB724A7D54A39943" modified="2016-09-07" version="1">MLEYIRHLIIDEDYSTTLQYLMRYPPVADAHSLIQYALHIKSPKKFEVPQTLNVTNFENITVTGMVHPNRTKGAIETKTNMEKPKQTNSAKQFSSSGRMLYNTIENKQQHGDSKSFVAKIVDTLSDRNIAERGLIRPQINYGTGSNMTMKASNEIIELLQEQVSCLQSRLNDMDMMVGVVKQRIGFIIDEQLSKIVGNDDLKNLIAEELHSIQSQVENATRSDANNQANVALSTRYRKEVIRNTSMANDVIEVGNEVHAPSFRLLHNNTGSSSMQQFQAAESGTEMREIRPHSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBS6</accession>
    <name>A0A183HBS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004004">
        <property type="protein sequence ID" value="VDO41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBS6"/>
    <dbReference type="STRING" id="387005.A0A183HBS6"/>
    <dbReference type="WBParaSite" id="OFLC_0000493701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000493701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000493701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF103">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000493701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26475" checksum="0AE686DECA3BF817" modified="2016-09-07" version="1">RSIISKYAQFFNVSSHHPLEKVPTESAASAAINFLQTAFSAVILMSALVYFFIADLSAVVAVVISILSICFGALAYLHLWNVRLDAISLISLLMSIGFSVDYSAHICYHYLIQRDNKKSEERCHQPISIIVGSDINIKNSSIVPSINSSSSSIQLNIDTRARLLVTFKNVGWPVIQSGLSTLLGVLPMIMVKAYVVAVFWKTVLLLIVLGMIHALILLPIILIIFSDLKCYIIRFCRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBT5</accession>
    <name>A0A183HBT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4945</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004012">
        <property type="protein sequence ID" value="VDO41536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBT5"/>
    <dbReference type="STRING" id="387005.A0A183HBT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000494601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000494601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000494601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000494601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45023" checksum="35921D8C9AF55232" modified="2016-09-07" version="1">MTRFKQFLVSELKVCSEAEAANRIFFISAREMLDLRLKERGLIRHAYQVEGHQYRTMEFCNFETQFEQLISKSAISTKFEAHTRRAREIVGEMRHNLDVVQNSALKRKTELQVNYTAKEAEFKNCLDKWKEFERFAVIESQRLRNEVHLKVSADFYEEIQKLESIIDRFDSKFVDEPVSIEEYKKNLADFVDKVVTEDLEARCTRGLMQRIWNLENAMYLHVNQILAEPYTKKLEQIWRYRPPFNFSICINCPSLIQDFREDLEFRFSFGITAIIRRINAYRLGKPVTAVGNQPLFEVFKSYSKQINKEADEGTIQQNCQEEKQVMTAAESQENAVMAQLIFSSVGYVANGGIGLLIIGGIVSFRIFLVGSFQYFLDCFFQFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC65</accession>
    <name>A0A183HC65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF1512 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5077</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004180">
        <property type="protein sequence ID" value="VDO41969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC65"/>
    <dbReference type="STRING" id="387005.A0A183HC65"/>
    <dbReference type="WBParaSite" id="OFLC_0000507601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000507601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000507601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO41969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000507601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32951" checksum="DB3872688B8C9FF3" modified="2016-09-07" version="1">MIIDGYSVLFLFTVGVLITIILAIFVQRQIFRMRDNSLRQEANIVVGAGLSKRKKEELDRGIEIVRQFQLLRAPKFTEIETIAEHASAPYLNRMIAMDELREIERQLEFINSDLGRIAGESMYAYLSRIRQIALPSLSEHLCERIGLLAEHCRYRHQPFGESELTETRALIKEIVKILNNEQERLSALHIKESTSSTLQEITKRLTAGENKKGTRNRNTAVNVIRNALELLPSDKNEARLAKAGDDQRKSLRAGDKKTISDTPALHILSSRITTIDTQNAQPLERIPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCF6</accession>
    <name>A0A183HCF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5169</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004300">
        <property type="protein sequence ID" value="VDO42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCF6"/>
    <dbReference type="STRING" id="387005.A0A183HCF6"/>
    <dbReference type="WBParaSite" id="OFLC_0000516701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000516701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000516701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000516701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9519" checksum="4DCE79BB5925875A" modified="2016-09-07" version="1">MQPLGIILSAASLDIILHDTYCVVAHFHYTLRCGEKLRVFESREALRYFQFQTVYSRIARCFCFLTKKISEETRQVDKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCK7</accession>
    <name>A0A183HCK7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5219</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004364">
        <property type="protein sequence ID" value="VDO42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCK7"/>
    <dbReference type="STRING" id="387005.A0A183HCK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000521801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000521801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000521801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000521801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27061" checksum="4A7A865CD68699E2" modified="2016-09-07" version="1">MYLIGLTGGIATGKSTVSQIFVENHIPVIDADLIAREVVAPGERAYKKLRQHFGNDYFDSVNGELLRKKLGDLVFSDEKARHLVNSITHPEIRKTIAFRILQHFFRGEKFVILDLPLLFEAGYAKILQKIILVDCLEDIQLKRLQQRDNIDEEAAKKRIEAQYPMSEKRRRATYIVNNSGDIEKTRAQVLNLIREFNASKLHLIVRTILLFALLIFFLLNYLLYHVILLPLFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCV9</accession>
    <name>A0A183HCV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5321</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004512">
        <property type="protein sequence ID" value="VDO42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCV9"/>
    <dbReference type="STRING" id="387005.A0A183HCV9"/>
    <dbReference type="WBParaSite" id="OFLC_0000532001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000532001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000532001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF27">
        <property type="entry name" value="LRRNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000532001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33081" checksum="805F1D719256D463" modified="2016-09-07" version="1">MQLQCSVLIVPRTLLTSKSRQRYSNGILILRRSKVSEISEFELVLITHQNRNGQLLYITRGSIERIHSAKIQFGSVTIEMNNPSVLICIKEASILALRNFISKLQQISKGEEVILDEDKKVTSSNFASFRKRLIMTSKKQYKEHKLGFPSYLQELVMSNIGLASVDSRWFGATSLHRLDLSGNKLGRSDAFGTKFLNIVRLRHLKVLVLADNEIQDISDDLWNALPENLLSLDLSNNQISYLSPCCTRFPQMTHLSLSHNRIEELPRTVRFAKLINRFLEFIIKKFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCY8</accession>
    <name>A0A183HCY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5351</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004553">
        <property type="protein sequence ID" value="VDO42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCY8"/>
    <dbReference type="STRING" id="387005.A0A183HCY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000534901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000534901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000534901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000534901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45883" checksum="E8615EEF0223843F" modified="2016-09-07" version="1">MLQNFAATAKNLHFIEMLPNNWSCDNCLNKWRKMLPFKLRPQMNCANDLPNNCSIGILKRAERNAKYILRVPYGETAILPCDEYGELPLLIEWWLVRPKVLIGNYDVENRVIKMNWTRNGTYEIIPGGLLLINNARKELIERYKCAVSNSKGNASQIVHFRLDYSSWFHLEMAKSVFWGSILTAFITCGITFIFNLLWIICRQIGLWWIKRMERNSHIREVVGAVEKYRQRQMTMLSETYHKKLEQIRDNYHQQVDQLCASYTLQSERFRDYRAAQMESMNQHLENIRDNYNQQMCKLRDYGSKRVEQLWETYERQVNRLRMFSLHQRLNLMRKYKVKQQYLNKLMAKFADNPSQAFMKPVNFTKILMNFSSFMKKHYVLSCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDC9</accession>
    <name>A0A183HDC9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5491</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004750">
        <property type="protein sequence ID" value="VDO43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDC9"/>
    <dbReference type="STRING" id="387005.A0A183HDC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000549001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000549001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000549001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000549001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25382" checksum="9324385AD985B8FA" modified="2016-09-07" version="1">MSKNQLEHASAVGRAIDKRKEDVVLVLHNIDGPGLRATLEQWALAEFAKAKHTHIIATVDHINKSLLWTQKLLNAFNFLFINVNTMQAYKTEVYAGCSKLLGLNPKGSGYMHTFSSLDVVWMSLTSNSRSLLHLITNYCYRKKKAVEFFELFRLARDEFLVSTDAALRQHLNEYNDHRLIIRKRHSDGNEYISMAVEERVTCTFFFLKFELQNNCGDCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEI0</accession>
    <name>A0A183HEI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5894</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005318">
        <property type="protein sequence ID" value="VDO44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEI0"/>
    <dbReference type="WBParaSite" id="OFLC_0000589101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000589101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000589101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF21">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="35"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000589101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25956" checksum="3C8A38D0C3B75C3D" modified="2016-09-07" version="1">MENNTQNNTEWEIIHHNKLDSGFVTYAFALPIQTISALLIWIVLKITVTKKKRKENVKSFPIYHISLIRICAHIINCIKFIRSMGLIPFPWRIFSRIVSPLANSTLYAAIWMQLVLAINRLWAISHPMTYNRAFNPKNARIIVVSLWLFSILITALYYNVECEHYVETEFYSWSTLFGPCEHSFLTYIAVLLSDGIFLAILIVDIIASYHVIAYLKVYFNFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFG5</accession>
    <name>A0A183HFG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6225</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005798">
        <property type="protein sequence ID" value="VDO45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFG5"/>
    <dbReference type="STRING" id="387005.A0A183HFG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000622601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000622601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000622601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000622601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8356" checksum="3758BF127F8F2AB6" modified="2016-09-07" version="1">MDIGTNELTRPFRIPRRRAGENSTMDVIPDKTKRFRLGGQSDSRSPLASTSSVRKHDSAFSSRIVPPTKKKLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG25</accession>
    <name>A0A183HG25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6436</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006116">
        <property type="protein sequence ID" value="VDO46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG25"/>
    <dbReference type="STRING" id="387005.A0A183HG25"/>
    <dbReference type="WBParaSite" id="OFLC_0000643601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000643601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000643601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000643601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11528" checksum="EF1BCBD088FFB8B6" modified="2016-09-07" version="1">MRRHVHGTSDDKNEQEVESGYSKDFTRFKRYDCLRDSGREKTRLLEKFAKLCKPDAIYDRDKMSKTCKDNLDKLSKEKLKAYSNYVGFFRLCYGPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGG7</accession>
    <name>A0A183HGG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6578</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006335">
        <property type="protein sequence ID" value="VDO47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGG7"/>
    <dbReference type="STRING" id="387005.A0A183HGG7"/>
    <dbReference type="WBParaSite" id="OFLC_0000657801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000657801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000657801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002685">
        <property type="entry name" value="RAB33A, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000657801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28134" checksum="62EE5464EA948164" modified="2016-09-07" version="1">MSVPVHSDILGVQEFSAQRTEPNIIISAPKINTVITTLTPQMPLSNLHFPARNSAEESEQNKVDVGLSRVPYPVTTSADSFALSSTKKNAETTQTVSTKYASGTIYSYQPGKTYLKKRVFKVIILGDAGVGKTCLSFRFCNGRFPAQTEATIGVDFRERSVAIDGELIRVQLWDTAGQERYRQSIVSHYYRNVNAVVFVYDVSNPSSFHSLKDWINECRKHSVSSTNDTPHILIGNKCDLTHENKVKTDVAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGX7</accession>
    <name>A0A183HGX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6739</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006587">
        <property type="protein sequence ID" value="VDO47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGX7"/>
    <dbReference type="STRING" id="387005.A0A183HGX7"/>
    <dbReference type="WBParaSite" id="OFLC_0000673801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000673801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000673801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000673801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9384" checksum="F2D4CB20836E5115" modified="2016-09-07" version="1">MIFWFLYGLLMIVGITGNGSVLIAFTKNRRLRSARNIFLLNLIITDLLLCVTAIPVTPWYALTKNWTFGALMCRLMPLSNSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGZ2</accession>
    <name>A0A183HGZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nup96 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6756</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006612">
        <property type="protein sequence ID" value="VDO47814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGZ2"/>
    <dbReference type="STRING" id="387005.A0A183HGZ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000675301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000675301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000675301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="1">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000675301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33821" checksum="52CDD653821D1D0D" modified="2016-09-07" version="1">MIIDAEAQEESTDQSQMYLIDPVNEIECYFKEGEQTVMKLAKKNGTFIDGSSMNGRCGRVSWNHGRVLWMSDLPNSLAVRCFKLQCIDQVPTEYIIDLFKKIDFMNEIVSNEHTENLIPQDVPQRKPNGEFSDLINCSLAASRFNDMKHDSNVLELCDALFGSQITESTSYTKMLNRREEVAKWLQKYLTTLERHGKPPPPGPARILHLMLIGDLEAAAEEAVESNYPHLACGLSIFKHTDRVAYKNQIEYWKGTKECKFIDEDLLKIYLLMAGEMQAEINGRIIFVNDGLDGLQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH05</accession>
    <name>A0A183HH05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6767</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006630">
        <property type="protein sequence ID" value="VDO47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH05"/>
    <dbReference type="WBParaSite" id="OFLC_0000676601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000676601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000676601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000676601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13392" checksum="A152C586F1179FAB" modified="2016-09-07" version="1">MTSQTNHGRSRRHQTSVQSSPENHNSRNSKRDEDLEEEAEIPTSPDISDSQSSDDDDDSEDEISPVIFNHPLVDDLLDRFMRAQLQNDVNVNNTNNNKNNNPAERKLEFYHESNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIV8</accession>
    <name>A0A183HIV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7421</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007746">
        <property type="protein sequence ID" value="VDO50929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIV8"/>
    <dbReference type="WBParaSite" id="OFLC_0000741901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000741901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000741901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000741901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7442" checksum="26A0C3EC13A894BD" modified="2016-09-07" version="1">MKHNIQWNPLIDNTESKRWWSGNFKPWDGDFEPWSESNGGEDFIVFPGGRFGAWGDRIIMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIZ3</accession>
    <name>A0A183HIZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007807">
        <property type="protein sequence ID" value="VDO51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000745401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000745401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000745401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000745401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8605" checksum="C3D37B8DF648B6BC" modified="2016-09-07" version="1">MTIIATIILTRTVGSKRNENSGVDGGISDDNIGDTYTSALAVAEAAEETLVAAAALHGTNSRRKTCHILHPKTVIEETVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ80</accession>
    <name>A0A183HJ80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7545</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E(R) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007953">
        <property type="protein sequence ID" value="VDO51478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ80"/>
    <dbReference type="STRING" id="387005.A0A183HJ80"/>
    <dbReference type="WBParaSite" id="OFLC_0000754101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000754101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000754101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000754101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4577" checksum="946F887CBDB0EBD3" modified="2016-09-07" version="1">MESISSHTILLIQPVMRVESRTWSDYETTTDCMEGIRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ97</accession>
    <name>A0A183HJ97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-RVT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007978">
        <property type="protein sequence ID" value="VDO51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ97"/>
    <dbReference type="WBParaSite" id="OFLC_0000755801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000755801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000755801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000755801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16658" checksum="B318A05FAA62ACE5" modified="2016-09-07" version="1">MVGIYVKCKGIEIEEKYALSVKCKREHCVLHFRRSVASERAKRSGVDLFCCCCQIELLLTWQIELLLKVSVSSQWMKMVDRSVDAEDNRAARKAVWSTLVSPRKTSSRQGCAKCDTILSSRSPIRTAEDDATDGLFCVGGVRVGRWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJN6</accession>
    <name>A0A183HJN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7701</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008213">
        <property type="protein sequence ID" value="VDO52237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJN6"/>
    <dbReference type="WBParaSite" id="OFLC_0000769701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000769701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000769701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000769701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9788" checksum="2A1A172120B1AE98" modified="2016-09-07" version="1">MAFMYPMHFPTVPLRWDEPAWAIPCTDAVDEILLSRLESRINAQSMFTQMRSVPNVISGSTLLQEIDDLEEDDEEVADEDDEQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK62</accession>
    <name>A0A183HK62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein MON2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7876</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008525">
        <property type="protein sequence ID" value="VDO52962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK62"/>
    <dbReference type="STRING" id="387005.A0A183HK62"/>
    <dbReference type="WBParaSite" id="OFLC_0000787301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000787301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000787301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO52962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000787301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13678" checksum="B25A2A7709D320F5" modified="2016-09-07" version="1">MDDSERGERLARQEIKALQQTVIDIFVNLCDSDNNVKHSVVTSQSLVKLCHFFDRRKATDVLLSHLITFLNDKVDWRLRASFFECCPIIAHFVGRQSTYILQSLLEQVYIIFINKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLU6</accession>
    <name>A0A183HLU6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8455</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="UZAJ01009573">
        <property type="protein sequence ID" value="VDO55735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLU6"/>
    <dbReference type="STRING" id="387005.A0A183HLU6"/>
    <dbReference type="WBParaSite" id="OFLC_0000845701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000845701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000845701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000007">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO55735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000845701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17147" checksum="3549C3DBE376CE46" modified="2016-09-07" version="1">MFIRDPLQVFRERIEQDDMKSTEHFETVQSSNWMNMRFKPPPPDSEIGWRVEFRPSEVQLTDFENAAYCCFVVLLTRVMISFRITLILPISAVTENMKRAQRRNAVLEQKLLFRKGIATCNSPPCARGAGCTLDSDDVVEMTVNEIING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM13</accession>
    <name>A0A183HM13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aggrecan core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8526</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009717">
        <property type="protein sequence ID" value="VDO56111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM13"/>
    <dbReference type="STRING" id="387005.A0A183HM13"/>
    <dbReference type="WBParaSite" id="OFLC_0000852401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000852401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000852401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000852401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="36859" checksum="62F6CF56749D7403" modified="2016-09-07" version="1">ANDFGYGERIEEVTEASLIGQSQDFKTSVTIAEPTLASGEEFTVEITTGSVQQPLATAISPVESNITISSDTIDSKTESKISEKTTFLQKLPELSELNVGDTAIPSSIETTGASDATGSTLMHIVTSEVEIPEPYGEEAPQIIGLTKIMKTGPSILTADTTAAEASTTEGAKKELEATGTETLTKSSLETLEEFDVGSTKFEETSKNGMDTISSEASLATSLEESVTKTASIFKSASIPARIPMSPEDFGYGESSISGKYASFKTFNQATSKSSEEYSSATFPSDASELVTQKLLTVQEESITKEGIHDEKDIPSKIPTGPEDFGYGNAQEQSNVFSNPRAYSKGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMR7</accession>
    <name>A0A183HMR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8779</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010210">
        <property type="protein sequence ID" value="VDO57359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMR7"/>
    <dbReference type="STRING" id="387005.A0A183HMR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000877801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000877801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000877801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO57359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000877801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18425" checksum="77EA358766BC582D" modified="2016-09-07" version="1">MKLSTSNIQTCESGTTRYTLDALQSTDGRSKRKKELNTDKEISAIDLPGRLICNQCGKSYATTSNLSRHKQTHRPLDSPYAKQCPNCDRVYVSMPALSMHMLTHKAAHKCTQCSKTFSRPWLLQGHMRAHTGQKPYGCAHCGKAFADRSNLRAHMHTHSGRAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNC8</accession>
    <name>A0A183HNC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MUTSd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8989</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010612">
        <property type="protein sequence ID" value="VDO58294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNC8"/>
    <dbReference type="STRING" id="387005.A0A183HNC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000898901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000898901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000898901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF145">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="1">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000898901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29673" checksum="CFBF95B45D47F6CE" modified="2016-09-07" version="1">MQFTIAEFLDNEHFVNLEKCLAALVPRECLLVSSKMGISSVNLFGENNSQLDNALKKAGVRKELFQFTDQLPITLSDHIAEMFDPKYKDIHLSRAQKSCIVGLIQHLHLNDDGVKTRKFQLRNYKSAGYMYLNSAAVKALELFGAYQEDEDLMNDGGSLYELLNKCRTSQGQRLLRDWIRRPLHDIRKINERLDVVEALVSDSSCRAILHDDILRRIPDITSITRKIVQKKAGLQVPKSFSLQFMHIFYALFIFHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNR7</accession>
    <name>A0A183HNR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9128</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010879">
        <property type="protein sequence ID" value="VDO58809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNR7"/>
    <dbReference type="STRING" id="387005.A0A183HNR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000912801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000912801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000912801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF112">
        <property type="entry name" value="PATCHED-RELATED PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO58809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000912801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26364" checksum="D59EEDC7087AB9F9" modified="2016-09-07" version="1">MNEKPACLQKFFFSTGFRNAVQWSQRLDLLQEWRTIVARYSKFNVTVYEPFSMYADQLLTIVPVTKSTVIFAFVVMAIVLTTFTPSITTIVSSTLSILSINLGVLGSLSYWNIDLDPISMATILMAIGFSVDFIAHITYHYYKGQTGDKRERLKHALKSIAWPMTQAGISTILCLCVLGIIQAYMVKVFVKVVVLVVLLGLLHGLVILPVVFGAIPLRKRAIADIDKVSTTLTHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP66</accession>
    <name>A0A183HP66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011213">
        <property type="protein sequence ID" value="VDO59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP66"/>
    <dbReference type="STRING" id="387005.A0A183HP66"/>
    <dbReference type="WBParaSite" id="OFLC_0000927701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000927701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000927701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000927701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16768" checksum="59B0692D2396496D" modified="2016-09-07" version="1">MACLQKLRQDVATLESLFPKEHERFQVLSASVDEITVQFINPQNKPIVVTANVLENYPHVAPIWFSECDDSTVTAILQSLTEAEAPCYILPQTHELVSRLCSYYNVTIPTELISIGPVGDERDEGMESDDDYIVMEEETTSRKDAGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPB4</accession>
    <name>A0A183HPB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aurora kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS9331</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011330">
        <property type="protein sequence ID" value="VDO59780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPB4"/>
    <dbReference type="STRING" id="387005.A0A183HPB4"/>
    <dbReference type="WBParaSite" id="OFLC_0000932501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO59780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20250" checksum="C3A67346D14D1B71" modified="2016-09-07" version="1">MKTFPPELAAKYMYQLASAMDYCQQRKVLHRDLKPENVLISATNDLKISDFGWSVHEPSSRRNIVCGTLDYLAPEMTPERTHDSKVDNWSLGVMLYEFLVGKPAFEAKTTELTLNNIQNCRYTIPNNVPDGAKDLISRVCFLCIFRFSLRKSQMHNIQKISLHFNQLMKNDANLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPL0</accession>
    <name>A0A183HPL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011521">
        <property type="protein sequence ID" value="VDO60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPL0"/>
    <dbReference type="WBParaSite" id="OFLC_0000942101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000942101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000942101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000942101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9418" checksum="813CD9482BC80D4E" modified="2016-09-07" version="1">MARCGNKERNGRNLNLFQVVRLSKSSSTSWVPRILATYPPTPTILRLTHPPFCTYRLELIGEFHLQQFKNSDKPTNLSMNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQS7</accession>
    <name>A0A183HQS7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9840</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="3 6"/>
    <dbReference type="EMBL" id="UZAJ01012521">
        <property type="protein sequence ID" value="VDO63826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQS7"/>
    <dbReference type="STRING" id="387005.A0A183HQS7"/>
    <dbReference type="WBParaSite" id="OFLC_0000983801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000983801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000983801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO63826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000983801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23775" checksum="122F1FAFD7F2AD82" modified="2016-09-07" version="1">IQYTIGRVPIASTDFSTHAYSYDDSPHDFTLSNFSLAKEDFKFKIPYIKQALNLTGGMLKLFCTPWSAPGWMKTTGRMIGGGTLRGPPNGSYHVTWANHYVKFLEAYKNNGITFWGLTVQNEPITGVDLSYKFQTMYFNPKTERDFIKNHLGPTLRRSDVGRNISLMIMDDQRSQLPIWADVVLVYTYNLYAHLIVPFEVLKDKEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQX5</accession>
    <name>A0A183HQX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9888</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012621">
        <property type="protein sequence ID" value="VDO64208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQX5"/>
    <dbReference type="STRING" id="387005.A0A183HQX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000988601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000988601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000988601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000988601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8241" checksum="F94316998D67E48B" modified="2016-09-07" version="1">MQKYSRTGSTYGTQKSRPVFLKPSDDDTVDNRTGPLILEDRITEEKSNVVVNNPYLALSIQQQRSRLPIFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRZ5</accession>
    <name>A0A183HRZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013482">
        <property type="protein sequence ID" value="VDO67129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRZ5"/>
    <dbReference type="STRING" id="387005.A0A183HRZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001025601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001025601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001025601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001025601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10225" checksum="685BA559F64EB55C" modified="2016-09-07" version="1">MEIVIAVVQMHDKKFARIGANAFDVLLVNEPSSSSRHEIRMELPHCHASPNDDPTEIALSFVQHYCRFHFFFLFFFFHFLYFLIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSQ7</accession>
    <name>A0A183HSQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10521</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014102">
        <property type="protein sequence ID" value="VDO69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSQ7"/>
    <dbReference type="STRING" id="387005.A0A183HSQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001051801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001051801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001051801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001051801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="46" mass="5226" checksum="9F768309E1624A9B" modified="2016-09-07" version="1">MKKVTDTEENFLKNDVVYANDVAESDVAMTNITGQDYQNAVVRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT44</accession>
    <name>A0A183HT44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10659</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014436">
        <property type="protein sequence ID" value="VDO70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT44"/>
    <dbReference type="STRING" id="387005.A0A183HT44"/>
    <dbReference type="WBParaSite" id="OFLC_0001065601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001065601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001065601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001065601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7337" checksum="849043F1857B6D51" modified="2016-09-07" version="1">MTMVSDTVELTPIDPVLMIHHDCDDGIKPGKRKVKFKIPKSYITEGKTPKKIFDLGTLNLETTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT56</accession>
    <name>A0A183HT56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10667</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014454">
        <property type="protein sequence ID" value="VDO70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT56"/>
    <dbReference type="STRING" id="387005.A0A183HT56"/>
    <dbReference type="WBParaSite" id="OFLC_0001066801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001066801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001066801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001066801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24535" checksum="D81EA11755F6B331" modified="2016-09-07" version="1">MVDEIFKFQVKLPNHFTNRIVQQQQQQQQQQQQQQFFEMIPAHETISTKLYVGRVWNTLTEKDIFDALDEEAKKYSPRAKVERVFIPKPHRGFAFVTVNDPNVTKRFCQIRDFVIKGKSVCVSIPTPKNNAKQMQQQQQQQQQQQPMQSQDAYAAPQYPMQQLPQGSTYSYPQPLNYPVQYPANQNWVNPPRASYRTGARMAYGYDNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTM9</accession>
    <name>A0A183HTM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014928">
        <property type="protein sequence ID" value="VDO71771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTM9"/>
    <dbReference type="WBParaSite" id="OFLC_0001084101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001084101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001084101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001084101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3347" checksum="9FF755DE5B1DDE87" modified="2016-09-07" version="1">MSKLEAMPGWAILHLGKMSLLQWASFDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTP5</accession>
    <name>A0A183HTP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crinkler (CRN) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10857</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014961">
        <property type="protein sequence ID" value="VDO71887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTP5"/>
    <dbReference type="STRING" id="387005.A0A183HTP5"/>
    <dbReference type="WBParaSite" id="OFLC_0001085701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001085701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001085701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL44 dsRNA binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001085701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13501" checksum="1744DE10CCB610BD" modified="2016-09-07" version="1">MAAMDALMRCWGVAADKKFPFDELDSLNDLDHFNKPHYSLQDICGPSFVLKFVDLEEEQEPINVKEVALRYKKEIEAVVSNERFCLFADNSFFFLNWNKFWAHYGCWHSIATTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU39</accession>
    <name>A0A183HU39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015338">
        <property type="protein sequence ID" value="VDO73045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU39"/>
    <dbReference type="WBParaSite" id="OFLC_0001100101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001100101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001100101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001100101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4922" checksum="222951EF827E43D9" modified="2016-09-07" version="1">MFQQQLQREIFQSKRITSTNSIRSLQNMMIPTQVVQERPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUB8</accession>
    <name>A0A183HUB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11083</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015546">
        <property type="protein sequence ID" value="VDO73674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUB8"/>
    <dbReference type="STRING" id="387005.A0A183HUB8"/>
    <dbReference type="WBParaSite" id="OFLC_0001108001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001108001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001108001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19773">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19774">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO73674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001108001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15545" checksum="82372404A5076C45" modified="2016-09-07" version="1">MKDILLGIPCDEDPKHTAIFYCTVCESNMCGECSKRTHTGRILSKHCRVPVSEKPLSRTMCPYHSAYAIEFEVECLENNRLMCLLCRDYGRHRNHRHSLLEVEAAGLRERVREALSDFRSFISDLNAWNIRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVR7</accession>
    <name>A0A183HVR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11580</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016878">
        <property type="protein sequence ID" value="VDO77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVR7"/>
    <dbReference type="STRING" id="387005.A0A183HVR7"/>
    <dbReference type="WBParaSite" id="OFLC_0001157901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001157901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001157901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001157901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17260" checksum="A74B562A11DC270B" modified="2016-09-07" version="1">MDVEHHVARLMVELSKSQDDEIGDGTTGVVVLAGALLEQAEDLLDKGIHPIKIADGFDMACKKALATLENVAQSFPIQNRELLIESAITALGSKIVNRCMRRLAEIAVDAVLSVADLEKKDVDFELIKIEGKVGGRLEDTCLVKGVVIDKTMSHPQMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW55</accession>
    <name>A0A183HW55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11717</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017296">
        <property type="protein sequence ID" value="VDO78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW55"/>
    <dbReference type="STRING" id="387005.A0A183HW55"/>
    <dbReference type="WBParaSite" id="OFLC_0001171701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001171701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001171701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001171701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11899" checksum="24A95A444D94693F" modified="2016-09-07" version="1">MIIFLEEGYTRPLFEWIYALMLVLQKPLWHDVCSSIRQLAKHSRILRNTLDEKMPNSSIMREEFSLFIAIVGVYFEQLDLADQVSQLDDDTDETDETSSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWI4</accession>
    <name>A0A183HWI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017623">
        <property type="protein sequence ID" value="VDO79608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWI4"/>
    <dbReference type="WBParaSite" id="OFLC_0001184601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001184601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001184601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001184601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3773" checksum="AE070F8E2A7C41F2" modified="2016-09-07" version="1">MVINNVIIVAVVISRCSFPSHHHLVCINQKQSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWJ5</accession>
    <name>A0A183HWJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11860</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017679">
        <property type="protein sequence ID" value="VDO79838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWJ5"/>
    <dbReference type="STRING" id="387005.A0A183HWJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001185701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001185701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001185701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO79838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001185701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9696" checksum="A824F564D0D3EF21" modified="2016-09-07" version="1">FGFNIVGGIDQEYIPGDSGIFISKIGIRGPASQDKRLKIGDRIISVNGVLLAGKTHDDAVRLLHNTKGSAVLVIEQNAESRILNVKFPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWP6</accession>
    <name>A0A183HWP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11909</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017823">
        <property type="protein sequence ID" value="VDO80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWP6"/>
    <dbReference type="STRING" id="387005.A0A183HWP6"/>
    <dbReference type="WBParaSite" id="OFLC_0001190801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001190801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001190801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 4 C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001190801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18216" checksum="C78728D472247E92" modified="2016-09-07" version="1">MELYLCITHAPSESEFSDFEAEDPFMNNFIVTLDRQLAAFEPLLVPVNYQELLIAVCAEVSVQFERVIMKSVYNRLGGLQLDKDFRSLSSYLTNIAGWVVREKCARLSQIVSIINVDSVGEAEECFHQLQHHNLMLTSDEAMKVLGLRIDLPSDAIKNASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXJ1</accession>
    <name>A0A183HXJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WASH_WAHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12206</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WASH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018642">
        <property type="protein sequence ID" value="VDO82803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXJ1"/>
    <dbReference type="STRING" id="387005.A0A183HXJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001220401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001220401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001220401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028290">
        <property type="entry name" value="WASH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331">
        <property type="entry name" value="CXYORF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331:SF1">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH1 WAHD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO82803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001220401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18922" checksum="410D38E382252D0A" modified="2016-09-07" version="1">MSVCMIPNDASHDEAVEWIVLSLEQLVNLSNEIFQRLSNRIKNFSEHADRVQVDLNRVAKKIDQIREMNTAIVISAPSKFVKTENECQQSVLGRRLRTNVNALKKISVKHKYDLNDPKDFATILDEKRKFYRFTEKGIKPKKLSELSLCVSEKIYIFSSFCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY03</accession>
    <name>A0A183HY03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complex I-B15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12365</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039830">
        <property type="protein sequence ID" value="VDP11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY03"/>
    <dbReference type="WBParaSite" id="OFLC_0001236601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001236601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001236601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001236601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7372" checksum="9CE4EEDAF6A858B5" modified="2016-09-07" version="1">MSGHHRDPRVVNADKSPRVPYLKPKSKIGISWNRLLYNVRYVSRHWKDRIIVKTAAAVLVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZD2</accession>
    <name>A0A183HZD2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12844</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039952">
        <property type="protein sequence ID" value="VDP12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZD2"/>
    <dbReference type="STRING" id="387005.A0A183HZD2"/>
    <dbReference type="WBParaSite" id="OFLC_0001284501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001284501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001284501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001284501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31582" checksum="210D4EF2F22D4A0F" modified="2016-09-07" version="1">MAEESVVCGDDNIRIVSSFLLHSPPGEFNEVFNDVRMLLNNDVLLKNGCAAAFAQYNKEQFIPVKLESVDKQTLITPFNEMPNGRFYDPRSRNSFKYEHLRKEATDIQAESANDVSCETWRKAVQEEADKYIESHYEDTGITAVFVNNDSLTLCIESHRYQPKNFWNGRWRSQWTLPIADGRNGQCEIKGIIKVHVHYYEDGNVQLVSTKETSAKVTYTYLEYYFQDAVQENYQQMSATTFKALRRQLPVTGVKFDWNNTHTYRISKDLKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I055</accession>
    <name>A0A183I055_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin--tyrosine ligase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13117</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040052">
        <property type="protein sequence ID" value="VDP12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I055"/>
    <dbReference type="STRING" id="387005.A0A183I055"/>
    <dbReference type="WBParaSite" id="OFLC_0001311801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001311801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001311801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF145">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001311801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77258" checksum="60F1838F2FB7F4B4" modified="2016-09-07" version="1">MANETEESEMNEEIVATQGELLKFTSAALKYAGKNGKKLKNYNKYARIGEKYHLRFKMIKCNQALVKTILHSYGFEQCSSRNPNCNIIWTSSHLKPQVLRAMASWQRVNHFPRSFLLTRKDKLYECLGRSQILFGDSYNIIPEFFVTPKDYQKFVDHFNAQSHGLKPFIVKPVASSRGNGIFIIQSPGDIPLGSPLLVSRYIENPYLLNGHKFDLRLYVLVTSFHPLIAYIYSEGLARFASEKYCSSAKSYEQHFSHLTNYSLNKNNGKFIRNENADTEDSGHKWTLGALLRKLQSNGIDTNLLMVRVEDVVLKALFSVQGQIAAASKNIVAHSKCCFELFGFDILIDTGLKPWLLEVNLSPSLSCDTPLDLQLKSSLVCNVLTLAAVPLVPQKYVESRFPASCATFSTSNKRYVPKDAALLIAQRLKKKSIRCLSPSFSPTKIYTNSRERARNNLERWKMEFDRLGAFVPLFPRENSFYLYSYLMEDYDIVNWDARLFEDIYGDRFSHPFSEKTIKLVQKELMDCENVNFLIVEAASLSESVREALIPSLNMARRYMSRMTKPGIRYANKLPKLRPELRKRSSSFEETESKLRPLVANYDDVVYATSLQIDHAAFERVLDNEANPKIPLVEMPKITVIKIPSDSLSEIKGRQNLHSEPDENAESMLAILLTPSVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1Q1</accession>
    <name>A0A183I1Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoplasmic reticulum transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040322">
        <property type="protein sequence ID" value="VDP14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1Q1"/>
    <dbReference type="STRING" id="387005.A0A183I1Q1"/>
    <dbReference type="WBParaSite" id="OFLC_0001366401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001366401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001366401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001366401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21959" checksum="4321114C44B41BEC" modified="2016-09-07" version="1">MKKLMNRPNFTYCFVSLPWNAYEIRDLFPLENMDYIAFTARNVIILLSAMIIYAGCRRSYSIYFFERDAKRIVFLENEGAIAVPLILSALLMILYYGLKLSGDNDLEEKIAEQKSLQSRTLNISRQLLLKTSAKLDSISESTIENNEEMTKLSKDLLEKMKNVDDSSSEEYLISDDLPDSSLKDVLEQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2F4</accession>
    <name>A0A183I2F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">FYVE zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13916</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040466">
        <property type="protein sequence ID" value="VDP14994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2F4"/>
    <dbReference type="STRING" id="387005.A0A183I2F4"/>
    <dbReference type="WBParaSite" id="OFLC_0001391701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001391701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001391701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF271">
        <property type="entry name" value="FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN TAG-77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="163"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="340"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP14994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001391701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56550" checksum="A6A9CF2612152A01" modified="2016-09-07" version="1">MVKEAHKFLLEKISSKIENWDSRDPNMAECLKNGAGLLKCCLPYLKEKKKHVDDFIRLLQDNEELAHATVKFEEQVMGKISIIQQLDIVHQNVVRYTILLEAYKKHLIPESNEFEVCKEALVQLSKVSELVDRQISRAELEKRLIDLYRRLEGRFNVFEANRHLLFEGELMKQSRKDLQPRYLILFSDVLLICKYSRTPSLGTDANFHSEFYKFLVSRIRVKAEEHGEYETHFQLYTTQKSAVFIAKTKRERDDWVKRINEAKMEAKELRRIKIARNKVFNVRVIHKNEPAGKSTSDAKMSNNGSDHNVSLNNMPISGKHKYTPLWIPDPKATSCMMAGCSTKFNVLNRRHHCRECGYLICRSCVGYAPVKTNSYYMRSKVCPECYVKITKKWKGELGSTIFTAPENESLTKTSVPSRNAEGVVSGTVFLRNQKGGENEKWGRLTSHADGVLVLCFYNAEFFQAVTSEGLKHSKGKYRTKLNSWVCKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3M6</accession>
    <name>A0A183I3M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDNF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14338</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040778">
        <property type="protein sequence ID" value="VDP16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3M6"/>
    <dbReference type="WBParaSite" id="OFLC_0001434601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001434601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001434601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001434601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9691" checksum="D0DF4CB0A3E3AD92" modified="2016-09-07" version="1">MQTVPRSLCPCDGPKTPCSQSTAGMQVTMAEHCTPRVNACPVGLPSIHFVTECNNVTESAATRCITVEEAQRLYTCLPQFNFNKLWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I621</accession>
    <name>A0A183I621_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041730">
        <property type="protein sequence ID" value="VDP20747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I621"/>
    <dbReference type="STRING" id="387005.A0A183I621"/>
    <dbReference type="WBParaSite" id="OFLC_0001519401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001519401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001519401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001519401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9713" checksum="39204F25AD2FE754" modified="2016-09-07" version="1">MGLSSGSGTLGPVTPQQMIGVQCPELQNTSQANAAASWRYPTPPAAFSGHFMDAFGGGMPSAASSSQFALPNQLYYQHGYHPYLMPMMRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6U4</accession>
    <name>A0A183I6U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Innexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15456</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042172">
        <property type="protein sequence ID" value="VDP21968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6U4"/>
    <dbReference type="STRING" id="387005.A0A183I6U4"/>
    <dbReference type="WBParaSite" id="OFLC_0001546701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001546701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001546701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF17">
        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP21968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001546701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18420" checksum="E79ADE6A80BCC039" modified="2016-09-07" version="1">MQPSIQYCVGQQHQLIVVLLITVRCPPLKGLDPEKNISKWCHSSGRWMGKVEGDFSRPHGWTNFTMCFTQEVISMMNKLTNGSLVVAQEVARNARKLEFAFLCEAMFFMLEYFKTVAFCWMFIEGFYLHNKLVLTVFATDLRIKPYLMVGYGKMLQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Y5</accession>
    <name>A0A183I6Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase_S8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15496</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042250">
        <property type="protein sequence ID" value="VDP22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Y5"/>
    <dbReference type="STRING" id="387005.A0A183I6Y5"/>
    <dbReference type="WBParaSite" id="OFLC_0001550801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001550801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001550801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="7">
        <location>
            <begin position="134"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001550801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32430" checksum="07808AC5E39BD02D" modified="2016-09-07" version="1">MMETMYSMRDKIPPTLFPWSSRGPTADGALGVSICGPGAAITSVPKFTLKASQLMNGTSMSSPNVTGTVACLLSALKARNISWSPYLIRLALENTARLPKDQNRFAVGNGLLQVDEACNFILEHHSLISPLFTHFKIKINDVYARGIYLRERYQTCCINTYVISVQPKFKPESDNDAKIAFEKHLVLTCVAPYIKYPKQFTLMHQEREFTISLDPVGLEVGVAHFTEICAYDSEHISLGPLFRIPITVIVPLSLDDNSRYTIKRRFQCKPASPERLFIHVPEDADWACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Z3</accession>
    <name>A0A183I6Z3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS15505</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042268">
        <property type="protein sequence ID" value="VDP22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Z3"/>
    <dbReference type="STRING" id="387005.A0A183I6Z3"/>
    <dbReference type="WBParaSite" id="OFLC_0001551601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001551601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001551601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001551601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11733" checksum="22DEA885D2FF24D5" modified="2016-09-07" version="1">MNVHLFRRCMSLSAAVRATEQIVRSPVQVHGVEGRYAVALYSAAVKDKNLDAIEKDLKSLQNVYQTSAKFKNFVLDPALTPLAKVNTIKDVAKNLNVSKETLNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I710</accession>
    <name>A0A183I710_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042298">
        <property type="protein sequence ID" value="VDP22340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I710"/>
    <dbReference type="STRING" id="387005.A0A183I710"/>
    <dbReference type="WBParaSite" id="OFLC_0001553501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001553501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001553501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001553501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12914" checksum="B13897012B85725B" modified="2016-09-07" version="1">MSTKMVHIDNPILEKQSDDHFYHLGITKSAIDIPQMYGDVKFVCMGGSTTRIKNYAEIFAEEVGIKMSDNLSTTDRYVMYKTGQVLWVNVSFCLLITFEGLCSCDIFFFSMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I737</accession>
    <name>A0A183I737_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042342">
        <property type="protein sequence ID" value="VDP22497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I737"/>
    <dbReference type="WBParaSite" id="OFLC_0001556201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001556201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001556201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001556201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12371" checksum="8B52AB3FF24F13DD" modified="2016-09-07" version="1">MGYSMTFTRVCTVQLPLKFALQYITVQCPFKHKYEIHRQTHSYQIYKTYRERRRTQIYKQLQLNDLVTDISFQLSLNTVRYSAPMAQYIFLQYSNCVIHGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7M7</accession>
    <name>A0A183I7M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TAFII28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15739</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042743">
        <property type="protein sequence ID" value="VDP23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7M7"/>
    <dbReference type="STRING" id="387005.A0A183I7M7"/>
    <dbReference type="WBParaSite" id="OFLC_0001575201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001575201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001575201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001575201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25008" checksum="9EDC0FD4A1A756C8" modified="2016-09-07" version="1">MMLRRISGMAGWTDVADLLGELSDSDDNDEEKNSDTKDSTIERPSGSEASVSEVKTKSSGLKRKSDKDADDIPAKTSRRDLSIHEIELLDDPLFGLLDPTDFSTVDAISKSSLVSSSNAGPSNSKNKLSVHFAENVKDNEKPCMKETAEAGSSRQDSPETDDSDDEHSETALQPKKLSKQDEILRQKMQILVANFSTEQLARYECFRRSSFPKSAIRKVSFLNQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7S3</accession>
    <name>A0A183I7S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15785</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042888">
        <property type="protein sequence ID" value="VDP23875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7S3"/>
    <dbReference type="WBParaSite" id="OFLC_0001579801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001579801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001579801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001579801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7937" checksum="6CE219D8D16148FF" modified="2016-09-07" version="1">MSLAIGSAIENEQLTGSWRDFYEITPNDETVGRFQVISFNWDEVQKPYTIAIWLLLAGIAKMGLFFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I895</accession>
    <name>A0A183I895_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15957</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043361">
        <property type="protein sequence ID" value="VDP25333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I895"/>
    <dbReference type="STRING" id="387005.A0A183I895"/>
    <dbReference type="WBParaSite" id="OFLC_0001597001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001597001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001597001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RIMS-binding protein 1/2/3 Fn3" evidence="2">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP25333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001597001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14184" checksum="50E8097DC9EFD1EC" modified="2016-09-07" version="1">APIAPQHVRIWSITPISACVSWYPSDSNTEHVILLNAVKVGMCPPSVFQLKIGLPDPPSNVQVEMGPQPGTLLVSWTPVTSQPLPPSRAAVHSYLVYADGRNIAQVPSVNGKFTNIYILQMNLLINKQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8E6</accession>
    <name>A0A183I8E6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16008</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043569">
        <property type="protein sequence ID" value="VDP25923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8E6"/>
    <dbReference type="WBParaSite" id="OFLC_0001602101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001602101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001602101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001602101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4380" checksum="47FC78162359AE45" modified="2016-09-07" version="1">MKKCRSAEFDVIMDHENITQETSEIVEKLESKVKIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UBQ7</accession>
    <name>A0A3P7UBQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000585">
        <property type="protein sequence ID" value="VDO28999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="67" mass="7923" checksum="6A35EA93D43E0428" modified="2026-01-28" version="1">MFVCFGGLRIVRGFNDSLFLSLLGYGMAVEERDLEEWTEHWRRTNKWPLLGFAFSEYLQFKALCVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UVZ1</accession>
    <name>A0A3P7UVZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000337">
        <property type="protein sequence ID" value="VDO27294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="78" mass="8705" checksum="64B6A3AA2C6F1046" modified="2026-01-28" version="1">MYEKIIRLTIVNGYSIWTVGGVMISNQFDGSFLRKNCKQCLSAVIQNMYAPKFSGKLEKNIDRQGSSDPNISNLAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V2Q1</accession>
    <name>A0A3P7V2Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000247">
        <property type="protein sequence ID" value="VDO26673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZL6"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF570">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="178" mass="19915" checksum="C882682BE14F6709" modified="2026-01-28" version="1">MPSTGRIQTFLDLAVEGTAIGRLTFELRDDICPKTCENFRALCTGEKGFSYKGCVFYRVIPGFCACSGDFETNNADRSGGRSIFAEKYFEDENFILKHDSRGVLSMDNYGWPDTVSSRFFITFDEAPWLDDYHVVFGKLIDGFDTFDCLESYGILEGFGAQKGRTTATITIQNCGQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V379</accession>
    <name>A0A3P7V379_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004114">
        <property type="protein sequence ID" value="VDO41796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HC13"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="112" mass="12168" checksum="FFEFD4C0C1DFAFDF" modified="2026-01-28" version="1">MSSAIIVGGVSMVAIGLVGRMMLRNRLAFLKMAKTLPITNSMSKYYRGGFEPAMTRREAALILGISPSAPASKVKEAHKRIMIANHPDRGGSPYLAAKINEAKDKLESTRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V7T4</accession>
    <name>A0A3P7V7T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004852">
        <property type="protein sequence ID" value="VDO43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V7T4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="137" mass="15765" checksum="7C1D932A4965DD81" modified="2019-02-13" version="1">MILRSVNQNHTWFHLVVSIHAVSALTLCVFTVLGYVANTVPMTLVVLFIFQMFMALLGLTAIERNRRDYRSLYITVNAITTVSAIIWSIYLFINIKDQPIYIPVILLIIALLSVCFVIFMKLLNSWLIFKSLDPMHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VET9</accession>
    <name>A0A3P7VET9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006043">
        <property type="protein sequence ID" value="VDO46420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="73" mass="8492" checksum="55F28BFAEA989309" modified="2026-01-28" version="1">MLTVRDSIEGKEKGQIIIPKMREKDGARKARESCKGGEREEENEARYKERSVISRHVGHAAFRHKWVELNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XMR1</accession>
    <name>A0A3P7XMR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016266">
        <property type="protein sequence ID" value="VDO75721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HV24"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="136" mass="15877" checksum="CF0A42EBA0E7CE07" modified="2026-01-28" version="1">MIKFGFKWIKLKWHQYHYHLSYWNMAMLSTINDQLLSFINISDMVNEILLSTSRIYYHFSSSILHLLFFNTILKMILLPYAYGKTNIPIVNAINNSGNAVSDMDSLLPSETDNIFHLHEPIKNIIGENRISDVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XUN3</accession>
    <name>A0A3P7XUN3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017152">
        <property type="protein sequence ID" value="VDO78321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XUN3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="164" mass="18983" checksum="973245DCB7F11237" modified="2019-02-13" version="1" fragment="single">MQCGSNLLAENDGEDAARFGIAEASHSRLTFEDDFLDVNQFKIEFSFRTVLPNGMLWVWANYNNYTHYFFLNIMNGLLQLQVQGQKEPKILVYKSNKLNDGKWHDISMLKQGQEILLKVDRNPAQYLKDVPNPKLVRKRIYIGGVISRHRKQFNLTIPSFSGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y0W4</accession>
    <name>A0A3P7Y0W4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001990">
        <property type="protein sequence ID" value="VDO35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y0W4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27968" checksum="3AF5008092A19F21" modified="2019-02-13" version="1">MQDHDERKRREHTPSQLLCERIAKYFREADIHFLRLTDMRFTDRFVDRLLEAFETCKIRCKKVEISMCKLNYVSPKKFHQLLQLIECQNLSLIWLRGNHGHINSSREFLSKFLGLSFLSIFAVTPPTTIGDDEFLADFLEGKVTKCLEETVLRIDNSSITTNGICRAIDKWKQTNTHWILNLCVGSEHIDIDELLRHLSLNQSKPRQGAFRIAHPQLPNEALLLWDDKDGIHIASNGKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YTT4</accession>
    <name>A0A3P7YTT4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003630">
        <property type="protein sequence ID" value="VDO40605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YTT4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53826" checksum="39FBD1DFDE585328" modified="2019-02-13" version="1">MNLEVKNWESPSPFAFIQFADIHSVVCAINAYTQSAHSSGGKGKLKIYRLLFLFFFQMNWGRTIVNNKIWIGELPSSCSADYLREKIRVSFTDTFSEVIYDPRHREALLIFSNNEIAQKAFSMIKTKQVAFWNADEKKDVHVPVDYCSEKLHDYFVDRKFRGESGISLNGAGSDSYGSSSTSICSNSGLAIASTSTSSLLAPPPDPPSHLRDTSSRIDCRKSDSNIPRRRRSGERESCRNSSRPLRYSSYNRSRRRRERARRNDVSPSSSSSSSSTSSDSDLSSSSTPDRNRPVTSHSKNNIQCLRRDKTPIYPSSSRQTSSPLNSKPDRNFEEANITTGIALQTVTSRNSTRASLAQLLPPPMPSAPILNPVSLTSPNEKKQQEDYHQSTEASKNEREPTIRSIDSKLQQSIMSSSSSVENELSHETNGKSTAEHRNRKAEQEQQQSNVKQLENKGSHDSALYNSVVQGNFATNEISAITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZD22</accession>
    <name>A0A3P7ZD22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006411">
        <property type="protein sequence ID" value="VDO47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HGL6"/>
    <dbReference type="OrthoDB" id="5812882at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="356" mass="40715" checksum="9AFE1E4B1F3B7089" modified="2026-01-28" version="1">MRRLSCASGTVKEIRLVVRISGDHLSLEGLRRALYNFLFARANNGKFILQLGLNKHGKQPRSKKIETLLDRFGLERDEGPGTGGPFAPYSVAKRLKTYADVVERLIDTGLAYRCFCCGDTWKEMDPVKKEPTKLFFCSRECFTKTRSESRNMALDGIPHVVRLRIPSQAYLYRDVVHGELSKHLSATDQLLLRPDFMPTSFFADTVDNHTLCASHHVASSSRDFLQLAICDALQWSLPTFINIGSLRLRSGSRLLTQNNARSYVRTYNSVQELSILNFLLAGRGLRKTSDRNGRLFSLDEMIAQFDINTITSNALLINTYKLMKPERQETLLEQQLELDEEVRLFDMFDKNFFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AJ62</accession>
    <name>A0A3P8AJ62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040350">
        <property type="protein sequence ID" value="VDP14462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1U8"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="198" mass="22368" checksum="2C3772543586DAF1" modified="2026-01-28" version="1">MPKNKGKGGKNRRRGKNENDIMKRELIYKEPGQEYAQVIKMLGNGRLNANCFDGKPRLCHIRGKLRKKVWINTGDIILIGLRDYQDDKADVILKYNPDEARNLKACGQLPENAKLNEGGDDLDEGGVEFADTGALSDEDNEGSGNEDLPSIGSDSDEDEDEEEEETEDSDDERITEERLARTYVKPGARDRPQKKNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AXQ5</accession>
    <name>A0A3P8AXQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040520">
        <property type="protein sequence ID" value="VDP15201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2N1"/>
    <dbReference type="OrthoDB" id="5824328at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="158" mass="17284" checksum="DBDF1C1C2D854911" modified="2026-01-28" version="1">MSNRAGMSNEINVSQLVSDVSRTLNGFKNLFTSSPKASGVEVAAQYDTPPLSNIATDIFSGNVCFKACGMEDIQLAAQQAAELFITLRYCIITLTIFVIICMILLSVALGWYLIKTTLVFDERSGLPIGTAFSGTSVFSRNHYQKTQSLNPTEENLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EYH1</accession>
    <name>A0A3P8EYH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040356">
        <property type="protein sequence ID" value="VDP14493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1V8"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="223" mass="26741" checksum="F5279A06C82DADE7" modified="2026-01-28" version="1">MDRMVADRSDGIDLAFERAKAWTKYCKDLLNYVSRRVQLDLEHAKRIQNLANQSKTAISEHYLPLKDVFENSFENDIAFCEKTQETVKYIQDRFIKSLELRRDEHERQRRTLKNEWLRVTKQVKDTQQELQRARTLFGSRDDGYRKAQEISIRTESTGPAVGSELFRRRKELEKRRRNEEEALIKRDEAQNQVERLEVELEQRQHHMKDTKVLMFSKILSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FGG5</accession>
    <name>A0A3P8FGG5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041090">
        <property type="protein sequence ID" value="VDP18266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FGG5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF402">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP18266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="191" mass="21289" checksum="D020077011AEC874" modified="2019-02-13" version="1">MQYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWALDPKAEDMFDNGSFLRRRKRFKRQQSEPDYQSVAYPRAPFLPPAPFLSSAFLGTPSVPTFPRLTSIRPAPPPLPFPPLVARLSEGFPSRIPIANPRTLIGSATTHAAPPFPCIPTDISPHCDHQKLLASMAAEVIASSQSDSSDPMAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXP6</accession>
    <name>A0A183GXP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small conductance calcium-activated potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000003">
        <property type="protein sequence ID" value="VDO24179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXP6"/>
    <dbReference type="WBParaSite" id="OFLC_0000000501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000000501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000000501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000000501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18947" checksum="7DB854D05C46AAED" modified="2016-09-07" version="1">MGGSNSTPKTDTMMDHQPYPDMNVIFKSIPKMMQVADDMHRMTNYIMDLRNMTIGLVCLSVIGIFLFLIIKVAQSRSSFARQKRELGQRIESLEDRSLPRHHSHYGAYHGYLDSWHESRNQKSGSLGATMIDIEKIPMNQSQNNSSLNGTTATALETPNLLNGHAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXU9</accession>
    <name>A0A183GXU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ZnMc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS59</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000014">
        <property type="protein sequence ID" value="VDO24367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXU9"/>
    <dbReference type="STRING" id="387005.A0A183GXU9"/>
    <dbReference type="WBParaSite" id="OFLC_0000005801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000005801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000005801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF329">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00413">
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    </dbReference>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="61"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
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        <location>
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    </feature>
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        <location>
            <position position="49"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <position position="120"/>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDO24367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000005801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47209" checksum="835333ACC885E069" modified="2016-09-07" version="1">MSVPSTEAILRHYSVTIRDALKKFQKFAGLKPTGKLDVETRKKMQQKRCGRPDVIALQKLGEYKWKKNDLTYSIESLPKEPSEREVRKLNSSLAAFRRYIGTCNTTSVRSGQKMKNVAVHEIGHVLGLEHSSDTDSIMAPFYRDAVDRRGNYITPKLSSSDVKNIQRLYGLNDKKSNPRSTLTGIDFMKNHKELDFGTNSEHGSDFETDSSNGDNDSNHDRKTDIGCPDEIDGIITVDGSNYLFSGNKVYDFDHAGIKEEYLLKNLFSNGPPFVQGALSNPRTDRTLLFHGKMVFAYYLDRYKNKFMLEPNYPKKLPAALNFKPMGAFLWHEGSQVLINVKGNHFATYDENWNQVTLQNEVVNYFDNFPAKPIRGVLIQQMNVLLFGDDKIYKYDIKDKRVIGKAIPLKAFLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXW5</accession>
    <name>A0A183GXW5_9BILA</name>
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        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">OFLC_LOCUS75</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Filarioidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000017">
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    </dbReference>
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        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDO24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000007401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33632" checksum="0B3F5743C81A8D96" modified="2016-09-07" version="1">MSRRNLSRPRIDSSTPKSFYCSPKSYHYIPFAQRRSQLANFKRQTGEKFNHSSISEAQNCQNRLWSQLSEQRGPCLFKKEDTSSKGSPVSSKIFKTTFTNTSANRSVSRNNQLQVLNQQQSKEVFNLSQSKIQSQASSCVHSNYDGEMSEKLDQFKSEILDNIIQLGVYTDRKIANAQANFSVIQDCISRSVTENSTLTMANLQQAITELLTDIGVINIKANKKASIANSDFSEPADEEILNYENEEFESDEDESSLAIPSVESYSDKLAEEDKSPGSNFGSVSITGSLTTLSNSSVTDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY69</accession>
    <name>A0A183GY69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS179</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000045">
        <property type="protein sequence ID" value="VDO24859.1"/>
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        <property type="gene ID" value="OFLC_0000017801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000017801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23120" checksum="371D4E1FE9C9EB04" modified="2016-09-07" version="1">MDASDVRFMRNDKKWLCAHLQKQEVRDERRAEKGVIDESGRNRITGPLFQFEALPSTNTTSIAPNTSGDASVKMPDRKQNEDSGLQEVHRLLKKFNTVREQRAKKCIHEDMIAETDNRHDQDLMMQLQYQYVSRISIPHSHSSSDSGLHPLYKEKKKCLKNSSLSKGMNALELMESESQPISQKYHPVVCVMSPSQSTSMAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYX3</accession>
    <name>A0A183GYX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000140">
        <property type="protein sequence ID" value="VDO25777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000043201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000043201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000043201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="416"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000043201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1557" mass="176097" checksum="8346DAB763B0C424" modified="2016-09-07" version="1">MDVSASSTFDIGKDDRSYGFDGFFEVVLPPTSAALIFLLLPTTSYGNANTKIESMGRLKATRKAIYLARKWHQGSGTYGREWKIGDIVGAFLDLSDHTISFSLNGELLLDPSGSEMAFDNVLVIDGFVPAMTFSAGQKARLNFGQDSNSLKYFTTCGLQEGYEPFCVNMYRQMPMWYAKRLPQFEDIGVNSTMEVSRIPATGNSPPSFFDLTSYSNEDDLIEKYFHVKYKKTSMAMADTIIDTGDMTVQEKAKMEYIRLSLPVKCNDKLQPTKDKESIMRSVHEIEKQHLAEEVQSVTMIRHPTIPREFGDDTKVNKKKLGRSLLSAFKHSTEEDENLTRSKPISFENDQLLEPSTLRMSGSMLELSSNDEHRIVKHKRGGLMARLQQRKNENKRTLADGHTVNADAISAESMPPSILKDDQDMPRSGPGRYRRLMSGKPKKNKLEKQAFMENRRPSIAALDQSVTAEGSVPSDDMRAMIELSDKIDEFYYAIRIFPGQDPANVWVGWVTPKYHFYAERFIIGEAVRICKYQEINKNVNEGESLEYRNCYVINAAELLQSVSDAGNTKVSGLLIGCIIDTSIGELSFLVSNQDTGFRFKLEPGAILYPAAFVAPTSAEVLQFELGRIKYTFPLSSAMFKSSHKSLLPFCPPRLTVEKLNPVHWARVPTECLRTTALKLSDSRGWSVLCDDPVRIMSIYVPEKDTSYDILEMIERNDFLVFHRQTLNLYCKLAAHGNQKVAHILCSHVDEDQIMYAVKSHYLSGPLRQGFHDFLIAVHLRTYVDARQSTSHEYVIPLTQSLEIKNVFQPENEGRFPQILGPTISIRPVTVRSEIRRDSGTDAESKLLPPAFNFAALKTHVMSALSSATEHAVINCRDLIGGNCLNHFEPLFKLFNSLLVIGIFDDDDMKDVLKLIHPIAFDENYVAGSKQKGLTEIELAEGVKIQLTIILENICDIQLRHRVESLISFAAGFVGDLQQDQFSRYMSIKQTDMSPAEAARRTKEFRCPPREQMFRLMKCKAVSDDSVGIMLDDDTEYDQCPMDEILQQQLREFCSLLVSKIGCIKNEERNELSELVVLEEANSWVDQLAQLVIRVPPPLAGEDNTTSHNGTENFRLCADRITLNTLRYCLIDKFRHMICKMLKSWATSSTIESNELIRKMFSLLLRQYTGVAEMMKALSQTYVLHERNIEDVQDFIENLVQVRELLSVQFQSTEEAVLKRGLWKLMNNRIFFQHPDLMRLLTVHENVMSIMMNVLTAQQGAADHGEHAERIENAENIAHAQESKNASEMVVACSRFLCYFCRTSRHNQKAMFEHLSFLLDNATMLLARPSLRGSVPLDIAYSSFMDNSELALALKEEELDKVTVYLSRCGLQPNLELIAKGYPDIGWDPVEGERYIDFLRFCVWINGESVEENANLVIRLLIRRPECLGVALKGEGQGLFSAFKEAIALSEDIRALEEDKNRAVVYSVLLREQPHYPNKEAEGEDYVDLGAATLDFYSSLVDLLAKSNRTIRKIFQAGKGDCVRARAILRSLISMDDLGQILALRFTIPNLIASTAIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ40</accession>
    <name>A0A183GZ40_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neurabin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Neurabin-I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neural tissue-specific F-actin-binding protein I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein phosphatase 1 regulatory subunit 9A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">OFLC_LOCUS500</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000169">
        <property type="protein sequence ID" value="VDO26006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ40"/>
    <dbReference type="STRING" id="387005.A0A183GZ40"/>
    <dbReference type="WBParaSite" id="OFLC_0000049901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000049901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000049901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09512">
        <property type="entry name" value="SAM_Neurabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000010">
        <property type="entry name" value="Neurabin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000008">
        <property type="entry name" value="Neurabin-1 isoform 1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040645">
        <property type="entry name" value="Neurabin-1/2_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043446">
        <property type="entry name" value="Neurabin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154">
        <property type="entry name" value="NEURABIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154:SF6">
        <property type="entry name" value="SPINOPHILIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17817">
        <property type="entry name" value="PDZ_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="276"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="18">
        <location>
            <begin position="650"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="408"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDO26006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000049901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="734" mass="82608" checksum="CC7C40AC8C559284" modified="2016-09-07" version="1">MSVLPLELDLCEDARSRFTHTKALFEQLERGEQSPYYFSPRMSRPSPPPLPPKPSVQCPTSPLSQVKRNFSELVSDLDRLSTTHSVLATRINGVDSLSSPMSALDSVITKKTSYEPYWRDPSFYKRRFGGLEGLAMNGTSDNDSIENADAISAVAQDENDKEQTVKHTTYALVKSRKPESDDDNQLQGNGTDIENTTGFNLLEECSSGTRTDSNGDLPGVTEVIRGLSPEFDVAGRKVFSTHSIMDYDRRNDEIDPVASCAEYELERRLDKMQIFDVHLKKGAEGLGVSIIGMGVGADSGLEKLGIFVKSITPGGAVHRNGQIRVCDQIVSVDGVSLVGVSQIFAAETLRATGSEVVFTIGREENLEESEVAQLIRQSLEADRFREAEELEEDEGDSDDSEEPILKEERKIRKRINDLELELTESQKKADQMKEILESSRAHYAMLENKYEQANQLLRSYQEREKELLEREEAHVDQLRQKDAHYSALVSQLKERIEELERRLDEMAQRRTTVMEGELSELKEQLAARDVSPALAYKPTGPTDHDSIKSAKILAMKTSSLPSKSASTSAYRRVNGTESACESIADDASDEQKSSQDSPIPRISEPASPAVLHKFAHRRILFPLRRRYITTEHEFWRDTFQSIQGLQVLHWTCDDVCQLLIQMGLDKYIPEFTVNQINGTKFLDLDGNKLKAMGIQNHSDRAVIKKKIKAIKSKIERERKQLEKESRLRTVAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZD6</accession>
    <name>A0A183GZD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000208">
        <property type="protein sequence ID" value="VDO26355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZD6"/>
    <dbReference type="STRING" id="387005.A0A183GZD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000059501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000059501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000059501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000059501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59866" checksum="3C878807F1D432AB" modified="2016-09-07" version="1">MDKESRDTILGEGQARLYICDRRRAILEKFSSLPSCSNSVTELVTARKSVFHADCYAHTALNNWTYRFDMTEWTRNFDIIEMKQRCIFELFALHGSCVSSTHCETVVVRNMQKNVWHSHRPLNGKHKYLYCTLLKVWVQNFGAFLERDQGRLVIDNALAPPAICNQVANVNSENKIVSSDSSPTSRASSQSPHAYRSGGSSSGSFSFATSMPYNLLPSSQKKAQIIPNITSTAVLSESVSAELTRLSDGRFERLAEQLHQIHPLHLIFHDLSWYQKRPTLLLFWFLKKLPNLRRLTLDSIRGDQMIELHKVFCVDGIDELNIIQPVYNACIIVNEGLFDSFLQVNSAIRRRFRLRITGKTDIKASALCNFIRKWRNHREIIPFHSILIDEACVSSSEFVHATKCPGCSDCGGEVLRHKSNKTTWNTKQLVFRHRKYNVWINYKSESGYLVFTYYNPKDSNHFTVKTAEPESTVVSFYSSTPLGVEKPEESDIADRTWSLFKKPTAAADELTVLQRIFALIRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H025</accession>
    <name>A0A183H025_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS835</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000333">
        <property type="protein sequence ID" value="VDO27269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H025"/>
    <dbReference type="STRING" id="387005.A0A183H025"/>
    <dbReference type="WBParaSite" id="OFLC_0000083401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000083401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000083401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF15">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0868">Chloride</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000083401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13000" checksum="037836E8AE647169" modified="2016-09-07" version="1">MYPVMRQEFFWKFSLSDLPFPLVFVKPTANELKKKATASEDILLDQAIDLNEAAIDSAPFQLVLGSSLHKVHTLFSLLALSHAYVTDRGRLVGVIALKEVLFCMFIFITILQNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0P8</accession>
    <name>A0A183H0P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1058</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000453">
        <property type="protein sequence ID" value="VDO28077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0P8"/>
    <dbReference type="STRING" id="387005.A0A183H0P8"/>
    <dbReference type="WBParaSite" id="OFLC_0000105701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000105701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000105701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000105701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14432" checksum="03DF75AD84CF948A" modified="2016-09-07" version="1">MSWLAKVSHIAGRAEDLLNQIDQNAAVILFKALRSTKKDANRSDSVMSLIDIEGEGTNKLEKLRPEMVETATKKHIRGGHTSSVSSRIHNRKKDDELIAYLNNSNEPTSSRCSSVASCFSAPNPHITSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H201</accession>
    <name>A0A183H201_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000726">
        <property type="protein sequence ID" value="VDO29811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H201"/>
    <dbReference type="STRING" id="387005.A0A183H201"/>
    <dbReference type="WBParaSite" id="OFLC_0000151001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000151001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000151001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF1">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000151001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41258" checksum="2F1938EB80E8A6AE" modified="2016-09-07" version="1">MRVYRFMIKTFNDENKFTIGMRIGQEVYSAVVDGVLDICDRRVKALLEDCYEIMCCSEIKLSMALGRRSPNEADDDDDDEPPSNVQEAARKVVTQAFRKGIIDAILPHVIQLKYYLQEKRLPELEFGIIRVLRELCKDHREQLDEFLASDKQLKAEIKFDLEKLEEKEKRIKVSNNNDGIRKASFLKNKTRVSFAADGVVSSPHLESEIPKQRYEVGMTAQTEMQNERNNGGDVLRADSIDRNDQKLTKFVEGQMKTVDNKNENVENVQPSISVGENFIPTAVTMIIKKRSQKIRFQQSNEESELPVRAVSTPEHNIAELTFGLGDEMSAIESTPTRKRSKRQARQPYVPPIKEADDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H313</accession>
    <name>A0A183H313_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1874</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000977">
        <property type="protein sequence ID" value="VDO31085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H313"/>
    <dbReference type="STRING" id="387005.A0A183H313"/>
    <dbReference type="WBParaSite" id="OFLC_0000187201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000187201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000187201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="247"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000187201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="50632" checksum="6F3C0B0D5E2AA3FA" modified="2016-09-07" version="1">EISELSIWKGIFQVEVESVFDLLLRSERTPWTLEEYRTRLMILRQLTYGAHTKHMPQGFDTVIETIPLRVIIGNLYEPFTIAWNELKNIIQDYAYGLSIDTFFSLFLSFINKMELNDQHAICENSGSLNDCHMLDKMTIIADKNPQNYGVFRLEMFKFLSRISDLCERRTKLLSPLFMRFFRNEYQQGNLLEKRQNILSLASSSLPCSTDEDEEKNDANEDPEIFGTEKSEDDGKEIAEDKCIERKIIRNSLIALLELFMNFTSPKVIYMASEIRDIYDELLMVGDEAVQQRALKCIFTYNYKYLTPYREYLESLVQERTLTNSLLKFAIDDHNSVVENNHRASLMPIVLRLLYGKCNIHCKKDMTERHTAIFRFLAGSTSNELDFFLKLLFAPLLKVIGEEEQSLEIFCKRTVSTFDASAMVPLQIIKGFAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H326</accession>
    <name>A0A183H326_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1886</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000986">
        <property type="protein sequence ID" value="VDO31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H326"/>
    <dbReference type="STRING" id="387005.A0A183H326"/>
    <dbReference type="WBParaSite" id="OFLC_0000188501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000188501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000188501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="722"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000188501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="995" mass="116189" checksum="4F4D704719E44E13" modified="2016-09-07" version="1">MQIELDAVREECSLVQEKIVQMGCVNFELEEQLKDAKEKLENAEIRVRQAEEQAREAHQNCAQQKKYQKSLQSEFLTKFDVAEKEINNLKEELDLKNEQLQARTIENNKLNEEMKQWRFAVDEMEAVHMEIQMLEKQLNDEKAAMESKWDEVRTILLERKGDMSRKTSEEESITDGEQKAVNQLRQMMDTVNDMKNTISEQAKQLELDKVNSSTQRRKFKAVIRQLQADKEALLASSVMKNKNDREQHMIQYETQLVALQRQRDFMDQEMTLLCTLNNSKDVLIQALQAKLEEMCSEKSGLSHLRSENNKNEDKNDRIEQLQIQIEITEQEKSEALNLLAKRDVELQEVQMHTQRLQMECDQLQLQLQSPKARNLDAMPTSISTDQHVQLQHAQQQMEVVNDERKHLLTAEKLTDGSENVITELRAQIEKFAAALEQKNTELQKVLNENETLKMKCVESTAALDLLSSEMERRSQEKDDIIEMLQSQHTYLTQTILLNEKRENQSSILPTVSQSTNVDAEFKCLMQDSSTFMDKAENDLIPVVRHHETQTMTDFHPSEAVEARQEQSSESSCKVIRDDNSVEPENHEICQCVNESNQMHDNSTDEIKQLVILNAELETAVEVLKGEIWTLNEQLKESLVDRENLSEKLCEFSQRHEDEVERARERERDLEEQKDMAERSQRQAALAENESNRRLVEWQVKSAQMEDSRIELESSYMKLSEYYQQLQQAYNALYARLNAVKIDCNTQTVIDSNNFKINEEIAEKVEYLKNELEQRKTELKDQTTELQHVRDLLRKHLHVTLKNVRDLREMNLNFLKDFIVDNVQTFQAQLQEALKEIHIYIEKVIIKWFKEKEFKDAEISIAVQQLMNDILTENISQTQDLSLSVIVDAVSKKFSERESENAALKNKLRDERSNKIALEMKMQQCSFDLLKINYAVWIVLKLSISEREKESELRIKELENLLQVTQVSLTEHVILCQQFQIKLAVPDSVTDQSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4V2</accession>
    <name>A0A183H4V2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2512</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001458">
        <property type="protein sequence ID" value="VDO33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4V2"/>
    <dbReference type="WBParaSite" id="OFLC_0000251101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000251101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000251101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000251101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7696" checksum="6DFC113B30C84119" modified="2016-09-07" version="1">PTLPSEKENWKKWGHYHHSNYDDRKFLSVYRETLLFTLNDPFTTWKQFLFFLAFADPKGQMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4W7</accession>
    <name>A0A183H4W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2527</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001471">
        <property type="protein sequence ID" value="VDO33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4W7"/>
    <dbReference type="STRING" id="387005.A0A183H4W7"/>
    <dbReference type="WBParaSite" id="OFLC_0000252601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000252601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000252601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="384"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000252601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52685" checksum="8F24452698D104E0" modified="2016-09-07" version="1">MKLLTEGIEILEEFTDKTPYTILFGPDKCGAKSSILFIVRFRNPKNGTISEHHAKQPSKSVSTYFDDHKTHLYTLIVRPDETFTILVDESKIMSGSLITDLEPSITPPTVIDDPTDKKPEDWDEREKIDDPDAKKPDDWDEHAPRKIEDANAVMPDDWLEEEEPLIPDSDATKPSDWDDSMDGEWEAPKIGNPKCKDRSGCGKWTKPMIDNPNYKGKWKSPRIANPNYKGKWKPKQIENPNYFEPHPYSQLQPITACGIELWTMSANIIFDNIYIGDDENAASNFAEQTFKIKLAQEAAYESASSPGQGILSKLVSATEERPWLWVIYILSILIPVIIIAIICFGRKSRPVTPDYKKTDEVSRIVGSLTIKDPQVLIPNYIEENSFSSSHPDDEVPDLVGDDDESTERSSQEPEAHDDNAKGKKRTPSGSPSRSRMEKEASSDEEIINGDHNSPKVRRIRQRKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4X6</accession>
    <name>A0A183H4X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MICOS complex subunit MIC60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2536</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001477">
        <property type="protein sequence ID" value="VDO33331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4X6"/>
    <dbReference type="STRING" id="387005.A0A183H4X6"/>
    <dbReference type="WBParaSite" id="OFLC_0000253501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000253501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000253501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000253501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16414" checksum="607C9B8ADB6FDC06" modified="2016-09-07" version="1">MGSAQSYEEGTHSSDHPKFQVVRIERNQIPEEYRTVAVSNDVVNQILNLGNPENENISDLRKQLAEEREVNFKLREQVKNLKESVVSLQRTTTGKISVAELQARKNAFDETLERIEKQYFSYHPENVCKMIETVSYYLHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H525</accession>
    <name>A0A183H525_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TMEM131_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2585</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001515">
        <property type="protein sequence ID" value="VDO33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H525"/>
    <dbReference type="STRING" id="387005.A0A183H525"/>
    <dbReference type="WBParaSite" id="OFLC_0000258401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000258401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000258401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056311">
        <property type="entry name" value="TMEM131_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022113">
        <property type="entry name" value="TMEM131L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24495">
        <property type="entry name" value="Ig_TMEM131_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12371">
        <property type="entry name" value="TMEM131_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552383" evidence="1">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like N-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131 second Ig-like" evidence="3">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000258401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30155" checksum="11F2672765AAE2DF" modified="2016-09-07" version="1">MIGSGSMIIGKCLLLTLVLQLDCTIHHCWATAEATIDLNIELPFMATAFVQTGNELHYFSDVEYQDSLISGASLKNSDQNAPMLNNQLQFIPSELQFDEQSVDMAKQQEVRVYNPTASTVRFDAISGSTVHFHCSFPEHKTVNPGESTTFNVVFLPRQEGLIENILIVHSSLGSFPYSVKGKGKESAYRLRPLVGAKIPVNGTLVSPIQIHNPHPTTLRVTEIYSSDGDLHLELPDVVPETPQPVSLWVWIAFFFFHYYTLCNSVCRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5B0</accession>
    <name>A0A183H5B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrmE-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001585">
        <property type="protein sequence ID" value="VDO33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5B0"/>
    <dbReference type="STRING" id="387005.A0A183H5B0"/>
    <dbReference type="WBParaSite" id="OFLC_0000266901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000266901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000266901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmE-type G" evidence="1">
        <location>
            <begin position="213"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000266901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44807" checksum="B8AA8689B41A9422" modified="2016-09-07" version="1">MLEAYVALKYLRRCSSIFAVSSGALPAAISVIRVSGKESLRCLKELTGRKKILPNQLFYANIRRNGELIDRGMAVFLSGPKTSTGEDMAEFYVHGSRAVVDCMLNTLAQFDNMQPAKAGEFTKRAFFNGKMTLQEVQSLAHLLTARTQRQRHKAMEGIRKQLIEVRASVEASIDFGDDVEFQWENIRCAISSMINELSSIQQQMHRGTLINEGLKVVILGQTNVGKSSLFNRIVNRDMAIVSDIEGTTRDSLEATVQFSSLPVTIIDTAGIRESPLDSLEAEGIRRTLRRAKEANFVIVVIDSNVCKDFETEVRFVLSRCYLKEDTPVFVALNKCDLSSIPNDLHLPWPTVSISCISGAGITSLLGIICEHINELCPMSDDSALLSNQIHQLLIKESIFTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5F1</accession>
    <name>A0A183H5F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAR_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001621">
        <property type="protein sequence ID" value="VDO33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5F1"/>
    <dbReference type="STRING" id="387005.A0A183H5F1"/>
    <dbReference type="WBParaSite" id="OFLC_0000271001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000271001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000271001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000271001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7471" checksum="8946D278A099F4A8" modified="2016-09-07" version="1">MTRMLYPGNLYIASEAEIPCQGLLKKLGEELNQLSQRMLRIYNGLDNNEMNPLLRQLFDLTQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5P8</accession>
    <name>A0A183H5P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIEZO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2808</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001712">
        <property type="protein sequence ID" value="VDO34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5P8"/>
    <dbReference type="STRING" id="387005.A0A183H5P8"/>
    <dbReference type="WBParaSite" id="OFLC_0000280701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000280701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000280701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="2">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="2">
        <location>
            <begin position="138"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000280701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43810" checksum="40E448D68C4809DA" modified="2016-09-07" version="1">MESMEYAFRNENNSPAGDNESIYSNSGCYDLKRDNPTYDFIAEQQSYVDFLKIIVFMYGHWITIIMVLVAGLGGVSLFALGYIILAFWILWQGTNLLHFLVIVSPPTFENFKVAFEGYNRQQLEGQEGIVIVQSSNGIVPVIDLIEEMIVAFILMYDPTVIFACTFVHVLIETDLCCIRQLFSIVCVNIIPGRINNYYLSSEQQEFDRECAVQKSETQIGFDTFAFGLLLLQLRIFNSWYFQHCMVEYRSEAVLMNRGAVLQDQLIEREMIEQNKQQEKKFKNIKVRTDQIRKDYEKRLSKAGAFIPQTYGHESAIDKNEHIKAVDTTKILDLIFSAKRAGDYYMFEYDPSEDALDKPVETFVPEVTPGASDFNKLDPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5X5</accession>
    <name>A0A183H5X5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS2886</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="EMBL" id="UZAJ01001782">
        <property type="protein sequence ID" value="VDO34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5X5"/>
    <dbReference type="STRING" id="387005.A0A183H5X5"/>
    <dbReference type="WBParaSite" id="OFLC_0000288501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000288501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000288501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000288501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38740" checksum="7C9F338C9CE425F9" modified="2016-09-07" version="1">MPFLRHQLTYQNSITVYPAPTRLPTEAFQIRISKLSLLVFNGHRPLTCLLPSSILREFQDSKSSCPYQSAKNQYAVAKEKDVIQSVASECPRYQDKDKEKSKQAGCASESEFNELNAMPPPNQKPSPGQPFPLSTERQRSTIPKATEDGYWEYPSEQMFWNAMLRKGWQWKDDQITAKDMNKIIKIHNANNEEVWREILKWEMLLHPECSCPKLKYFHGNSQKISPRARIRQLLGYDLPFDRHDWTVDRCGQKDVCFHLLKEIQFQVHYIIDFYDGGAVDLKSKLFTILDVRPAITDLGNVWDRMVVAYWRLKFEILGIAPKLPLYQKKQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6A6</accession>
    <name>A0A183H6A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CD63 antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001891">
        <property type="protein sequence ID" value="VDO34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6A6"/>
    <dbReference type="WBParaSite" id="OFLC_0000301601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000301601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000301601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000301601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17930" checksum="2F90F3BA0D11673D" modified="2016-09-07" version="1">MNLFFILRCTGLILMLIGSILFCYVPYRRLAVIKKKLEDISGFHVHYVGLLRHLLNFTDCKQVSWSSWNECTTDQQLSMTRQRELPFADCQVIHQNMSCGCKNELIKDIQEIDARSYVRYGCIPGSNQQLTVLSINATIINVTTSKLPGITLEPCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6D2</accession>
    <name>A0A183H6D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpene_synth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3043</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001914">
        <property type="protein sequence ID" value="VDO35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6D2"/>
    <dbReference type="STRING" id="387005.A0A183H6D2"/>
    <dbReference type="WBParaSite" id="OFLC_0000304201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000304201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000304201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000304201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26128" checksum="17D90E9E3E640890" modified="2016-09-07" version="1">MNQLGFKAIMNMDGDEIAAYDFVDLTVSQGCYLLEEAHKCIMEAISLFSGEKENSEVMLDRHTFRLAVHALRRGVLAVRVIELFPSGVFEELAYSEHEKAKRKISEERKRRATCDGKHVSGSGSNSSGCNSGTVKMFQIRRQTEYVVSGLKRHLVGITLMCYSILLLYYVVHTERSASDFIHALDYCDDILSSVPGIGTSLFDRELALLYARHLMQNCKFDGINLWFLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6R2</accession>
    <name>A0A183H6R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3174</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002044">
        <property type="protein sequence ID" value="VDO35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6R2"/>
    <dbReference type="STRING" id="387005.A0A183H6R2"/>
    <dbReference type="WBParaSite" id="OFLC_0000317301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000317301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000317301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="306"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000317301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65832" checksum="07671904833652D1" modified="2016-09-07" version="1">MSIYTVHIFYRLKLFQKFKWKKITILQSVEEVFTSTAKDLEEQCREKGIRVERQSFYGDPTDAVKTLVRQDARIIVGLFYVTEARRVLCQAYKHDLYGRKYVWFFIGWYADTWFIPPSDEPLNCTAEQMIKAAQYHITTESIMLSRDEELTISGMTGKQFQKRLMNILTTDPAETGGFPEAPLAYDAVWAVALAFNCTLSKLQAGQSLENFAYNNTGIAEKLFSCVKDTQFRGVSGQVMFNDLGDRIARTQIEQLQDGKYQMLGIYDTTTLHMDWYDKEKFATLNGLPPPDSTLIQESLLAVDIELYYAIALVAVIGIIVACMILIFNVRNSDRMIIMESQPQCNNLLLAGCILCCLSLLLLGLPARGITIPKHSFTLLCHSQISLLMIGFTFAFGSMFAKVWVVHRSGAAENQHLISKPTTGQPVPACKFYLVVTAFFVVDVIIIACWFTFDPIQRIEQRFPLQEPPIGTEEDVMFLPILEQCQSKRQEMWTGLVMGYKCLILVLGLFLAYETRNLRPLFVNDLRFVGLAIYNVAVLSLITGPVVTFLIRSQSDANFAFISITGLFFLSKLFFFLFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H700</accession>
    <name>A0A183H700_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase-like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3262</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002127">
        <property type="protein sequence ID" value="VDO35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H700"/>
    <dbReference type="STRING" id="387005.A0A183H700"/>
    <dbReference type="WBParaSite" id="OFLC_0000326101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000326101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000326101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF59">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000326101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="64059" checksum="E9FF38695051AADF" modified="2016-09-07" version="1">KQTAENSSSRPELQFSCSSAAKIDASDEKYNVVLDKGTLDSLLPSACNNMVEDVEKMFAEICRVLTIGGRYIILTLAQNQVLSTYMSFFLKRKNFIIRVEKNIDTNYKFPLPVFLFIATKLRVSLPSPYMELILSTEKKSVKFTDPVNLISAVNAEQEFSRFRHLCSKKLDEEVSIILHGDNEKPRYRIAVHDDPEVTVLSSFAVFIVPVGRDHDWFFATEKGRSSLRKQCCKDRLAVVTLFRDQKYENMEQVKDELGPYRKSVVEFLSLGKIDVKETRATGDSDVNGPWAVEDVRIQNSLYRRLVFLSAQNLVQSEVKLIRNRKGREIVDLHTLTSEYHEAMLAALPFMLPPCEKLSHSTKSRLLVLGLGGGVLPSFLHLKFPSMFVVAVELDQKIAEIATHWFSFNSDSHLTVVIKDALTYVEELVQQKNQSLLFDAIFVDVAGSTQKDGLSCPLPSFVTEEALKKMYAALHERGVLALNLVTRNDDIAEQIKDRILSIFSYYYSYCTEEDINQVLICPKVRKGLFEARRACENYKKEKGTLRNLFANISELKFYEKRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7G2</accession>
    <name>A0A183H7G2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="9">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3424</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01002278">
        <property type="protein sequence ID" value="VDO36444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7G2"/>
    <dbReference type="STRING" id="387005.A0A183H7G2"/>
    <dbReference type="WBParaSite" id="OFLC_0000342301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000342301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000342301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO36444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000342301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45086" checksum="D18721FF39BDA966" modified="2016-09-07" version="1">YEFHFRFKDFYEFFPERFQNKTNGITPRRWLLLSNSSLADIICEKIGEDWITDLDKLQELKKFANDLGFLDAIRRVKQENKMRLAQFLDQEYNVKINPSSVFDIHVKRIHEYKRQLLNILHAITIYNRIKADPNANIVARTIIFGGKAAPGYHMAKQIIKLIGCVSDVVNNDPIVGNRLKVVFLENYRVSLAEKIIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTLDGANIEMMEEMGRENIFIFGMEVKDVAELSKKGQVYYHYNPQDFINKSPELSKIVDQIETGFFTPDQPDLLQDVAMALKKWDRFMVCADYDAFIKCQQEVERTYEDTDRWTRMALMNIASSGKFSTDRTIAEYAREIWDVVPGELKLPAPFESSEQHQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7H2</accession>
    <name>A0A183H7H2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3434</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002287">
        <property type="protein sequence ID" value="VDO36476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7H2"/>
    <dbReference type="STRING" id="387005.A0A183H7H2"/>
    <dbReference type="WBParaSite" id="OFLC_0000343301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000343301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000343301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="89"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000343301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32032" checksum="63BD32B737B83C53" modified="2016-09-07" version="1">MVGYLMDILHRLYYFLFDRLILYPLLSLLRDKFNIRFMNLGYECKEDEDFPALEKMSEMDNCCKANITLYEKALSLCPKYPDFDGLRLLEVGCGQGGGIEWILKAHSFADVNGVDLITVNSCFGKIIRGSAEKLPFMNDSFDIIINIESSHLYGNCRQFFLECSRVLCENGFLCWADLRYTHQLETTMIEAQRSCLHLITMEDITEQVLQGIELTTKRYDAMLQNAPYFIRFFQNSIRTTYCAPGTRSYERLLKHEKTYVCACWQNYKRIKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7M8</accession>
    <name>A0A183H7M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3490</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002340">
        <property type="protein sequence ID" value="VDO36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7M8"/>
    <dbReference type="STRING" id="387005.A0A183H7M8"/>
    <dbReference type="WBParaSite" id="OFLC_0000348901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000348901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000348901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000348901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16642" checksum="E8EAB6ADF5849607" modified="2016-09-07" version="1">MKKRERECACCLCRLGELGSKLYYKQSMILCARDYLRLFGLTGTCAACDKNIPAFELVMRAKDNVYHLRCFACQACNQRFCIGDKFYLCENKILCQYDFEERMAFHQAAYNNQSLTELTKNIEQLENFEPVLTFNFWNQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7P4</accession>
    <name>A0A183H7P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3506</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002354">
        <property type="protein sequence ID" value="VDO36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7P4"/>
    <dbReference type="STRING" id="387005.A0A183H7P4"/>
    <dbReference type="WBParaSite" id="OFLC_0000350501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000350501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000350501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000350501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13673" checksum="15A547667194112D" modified="2016-09-07" version="1">MKENKLFDETEFSNPKSFDYNFEDDFKKLADRNDIYDELVPYLPTFILHKNGKDAGRTSVPIVTRKIPAWSTPLPRQKYVEPYEPFAKSPVERPDLRRTTTLVTKKPISQRLNFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7T4</accession>
    <name>A0A183H7T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLD phosphodiesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3546</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002400">
        <property type="protein sequence ID" value="VDO36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7T4"/>
    <dbReference type="STRING" id="387005.A0A183H7T4"/>
    <dbReference type="WBParaSite" id="OFLC_0000354501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000354501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000354501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000354501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37964" checksum="BF9E8C4377AB17E7" modified="2016-09-07" version="1">FLQIRIAQSQPTAAFPQLDSNYFSEHGYATVRNLNMPKLIDDNGVLHAKFWIVDSQHVYIGSANMDWKSLTEVKELGVVIWNCTCIANDLYKIFNIYWRLGVRGAKIPYKWPLNLRTYFNFSHPLKLLSANDASIFISSSPRRFSAKGREDDGDAIVAVMDNAHEFVHISVMDYMPATLYKTYNNTYWPKLDNAIRATAYRGVNVRLLVSHWKYSLLGMVHFLKSLLEINDGMPRIANHSGKIEVKLFTIPVDPSREQIPHTLVNHNKYMVTEKIAYFGTSNWAGDYFISSAGVGISFISPTLVKSLNAIFMRDWTSKYAKTIREFLLDVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8J8</accession>
    <name>A0A183H8J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3810</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002671">
        <property type="protein sequence ID" value="VDO37817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8J8"/>
    <dbReference type="STRING" id="387005.A0A183H8J8"/>
    <dbReference type="WBParaSite" id="OFLC_0000380901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000380901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000380901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="208"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO37817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000380901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35733" checksum="353C2E5AE73EA606" modified="2016-09-07" version="1">MKVERWVRRALDKGVDGLREEYLSLKRYTPEDMTTNAFQGTFEAGKSRYKDVPCQDKYRVILRWPGVTNDYIHANYVATPIDKKRFICTQGPMPNSVIDFWHMIVQEESDTIVMLTNTVEKGLNKCEQYWPNDVGDTLSFGDITISNLAVRALAPDETTVRVCLLKVRWKEGGLEKTREMRHYQWVNWPDRGVPPCKLTSMVLLSNIRGSKKPIVVHCSAGIGRTGAIVAIEYILEKLQQGIPCESMDQILKELRNQRPYTIQNDMQYLYVHRVMLFYFIDKYKVFADNDDMMAKYKVFVANYDKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8N5</accession>
    <name>A0A183H8N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3847</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002712">
        <property type="protein sequence ID" value="VDO37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8N5"/>
    <dbReference type="WBParaSite" id="OFLC_0000384601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000384601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000384601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000384601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9046" checksum="91579305326ADCCF" modified="2016-09-07" version="1">MIGISPTDLCICTFNFKVKNTEWLCFAYPQKAVKSVKEIRREQIPSVPPDLIKFRSDGKHFHKIAMRGKGHVLDEVGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Y5</accession>
    <name>A0A183H8Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002823">
        <property type="protein sequence ID" value="VDO38332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Y5"/>
    <dbReference type="WBParaSite" id="OFLC_0000394601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000394601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000394601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000394601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3927" checksum="38352A3F1EC67966" modified="2016-09-07" version="1">MFGPIAVNDKYNINWGFFSDLSKMLSKTAQQVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Z5</accession>
    <name>A0A183H8Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3958</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002830">
        <property type="protein sequence ID" value="VDO38373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Z5"/>
    <dbReference type="WBParaSite" id="OFLC_0000395601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000395601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000395601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO38373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000395601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25734" checksum="8AE3C6ED701839DF" modified="2016-09-07" version="1">MQNIFQKNFEKLPLVGFSVCSGIEIIREKLHPSNTVAFKRWDSSEMPSWAMNHVEIDDYLRILLRFEEKRLVVCFRLNSLPPSRSIYFDFLPNHPIEELYLALANSEIFNDEGIPFIAIPNRFEMLTWIAQRKQKKAVIKEERKVAKPLVEIATSNVATPPICTFCWERPIDMLLMPCNHAVCCKVCKDNYIKYERKRNKAKIVSTEVVCPVCRKKSTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9A4</accession>
    <name>A0A183H9A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4066</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002947">
        <property type="protein sequence ID" value="VDO38754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9A4"/>
    <dbReference type="STRING" id="387005.A0A183H9A4"/>
    <dbReference type="WBParaSite" id="OFLC_0000406501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000406501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000406501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000025">
        <property type="entry name" value="BTB and MATH domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO38754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000406501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41920" checksum="924F13FF4DAA699E" modified="2016-09-07" version="1">MADIVGPLRPSDSWSTTEVRSLQHSHVWTIRGFSQCECRYLETSVKIKETPVPTNTLDGNHLTFRIRLHPQGNKESNKDFSFFQVFCNTNSAKYRAKFSVYNAKNEEAPTTVYTGTQQLHGYFEYIRRDVLVSHIQPQDELQLVLSLTITFDTVTKSSQNSRQCNVPDARPAEIARDLETIYKEGRLADFTIVASGRELPAHQIILSARSPVFAAMLEPHTEEAKNSRVVFPDIDFEVMQELLLYMYTGRSPNLSNMALDLLAAADRFQLPGLKEMADQVLRTGLIVESACRYLVFADMHNARELKADAIKFIAQNSSSIITTDGWTELVKEHPVLVTEVVAAISSNDPRSLSASSSPSSSSEPTTKRARLSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAT8</accession>
    <name>A0A183HAT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransf_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4600</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003568">
        <property type="protein sequence ID" value="VDO40461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAT8"/>
    <dbReference type="STRING" id="387005.A0A183HAT8"/>
    <dbReference type="WBParaSite" id="OFLC_0000459901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000459901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000459901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000459901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22527" checksum="5B5E4AB3667D4FE4" modified="2016-09-07" version="1">MPSIARIIRLFRHKLTTPNDAADGMYMSGLLAWKSPFLMKAVVETLNISPDDNVLELGIGFGDGVLYSYKHVREGKGTIYSVDRWTSLFGAVQGRFPKKALEDKRIVSDAKLLPFNNEFFDKIFHVHSSYFWSSDLPATLAEITRVLKPGGIFLSGMHLKKLELLEKGKLIRRQQYDPSRYIFELEPAGFTDVRVRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB03</accession>
    <name>A0A183HB03_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4665</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01003659">
        <property type="protein sequence ID" value="VDO40676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB03"/>
    <dbReference type="STRING" id="387005.A0A183HB03"/>
    <dbReference type="WBParaSite" id="OFLC_0000466401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000466401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000466401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000466401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="17046" checksum="0B04C6EA7A95CD77" modified="2016-09-07" version="1">MKRFQLVRLPPYLIITYKRFHKNQWFVEKNPTIVNFPISNVDLYDCLAEEMRPLHKYTTYDLVSNIVHDGPPSSGSYRVQILHNGTQKWYELEDLHVKEILPQMITLAESYIQIWRLNTSKTREQRAGETEEDEGETMNKMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBP6</accession>
    <name>A0A183HBP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4907</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003967">
        <property type="protein sequence ID" value="VDO41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBP6"/>
    <dbReference type="STRING" id="387005.A0A183HBP6"/>
    <dbReference type="WBParaSite" id="OFLC_0000490701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000490701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000490701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000490701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58799" checksum="ACA785AEE74E6C89" modified="2016-09-07" version="1">MILVCDAYRKDLQHPNEFIRGSTLRFLCKLREPELLEPLMPAIRSCLEHRHAYVRRNAVLAIFTIYRNFEFLIPDAPELISTVLNSEQDASCKRNAFMMLLHVDQNRALDYLSEVIDQVTTFGDILQLIIVELIYKVCHANPSERARFIRCVYNLLQSSSPAVRYEAAGTLITLSSAPTAIKAAASAYIDLVVKESDNNVKLIVLDRLIELRTSPSSEKVLRELVMDVLRVLSASDLEVRKKTLQLALDLVSSRNVEEMVMYLKKEIGRSSDGTAEEAERYRQMLVRTLHSTTVKFPDVASNILPVLMEFLSEDSENAAQDVLVFVRETVQRLPHLRPVVLAQLLDVFGNVNSAQVFRSGLWILGEYCESAESVMRVMEFIRKSLGELPIVEKEMQKINGNEVLHEKNENSTTEVIPKSRQLVTADGTYATQSALSVMKTETMENKTLLRQFLLDGNFFLASSLATTLIKLVFNYSKFMKNKNDKINSFAGEVLFMIASIINLGKSDLAKTNATEDDLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCJ9</accession>
    <name>A0A183HCJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">SEC24 homolog C, COPII coat complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15731</name>
        <name evidence="2" type="ORF">OFLC_LOCUS5210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004354">
        <property type="protein sequence ID" value="VDO42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UZAJ01042732">
        <property type="protein sequence ID" value="VDP23522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCJ9"/>
    <dbReference type="STRING" id="387005.A0A183HCJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000521001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000521001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000521001"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001574401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001574401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001574401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP23522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000521001-mRNA-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001574401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8327" checksum="8D0DD70B43352626" modified="2016-09-07" version="1">MQTYGQPVRSTFPPTSAAAPLQGQGYGYPQGYPPQGPQYAPSSGYAHPQGQQVPPPTSMPQSVESSDAATPPMHQGTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCK2</accession>
    <name>A0A183HCK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nkap_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5214</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004358">
        <property type="protein sequence ID" value="VDO42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCK2"/>
    <dbReference type="STRING" id="387005.A0A183HCK2"/>
    <dbReference type="WBParaSite" id="OFLC_0000521301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000521301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000521301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="175"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000521301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32549" checksum="99FAAA765EFCCFA1" modified="2016-09-07" version="1">MGRIDIKKESSDDGDSHHQELDSLKKNAREDAIWAERRKERERRCEWGVRSVWGRSPLMHEIHQVYEEYEKVEEELRREEEQLPQPLSAKAAEVAKKSKKKEKGNKKKHKEKKKRKKKHKKSTSESEEEWVEVTAEMREAEAAREKLEEAAMIGPAIPDHLQQKHAALVDTAKRVNYGKDMLRGEAAAMASYIAQGKRIPRRGEIGLSSAEISEYEKIGYVMSGTRHKSMEATRLRKENQVMTAEEKRLLSGFTHDERKKKEEIVLQQFKSFIESKKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCK8</accession>
    <name>A0A183HCK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein Nup85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004365">
        <property type="protein sequence ID" value="VDO42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCK8"/>
    <dbReference type="STRING" id="387005.A0A183HCK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000521901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000521901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000521901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000521901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33456" checksum="EDAF358F9041EBD6" modified="2016-09-07" version="1">MLSELFAELIIDSDDCHADNRLNLNCTNLYMYAPLDQSPRWFLDDNLYHNKSDNNTREIVQNRAAFAYLQGDYITAMDIYFHLLENETKTGSCNSIFALIDSIIRCGLKIAPIHGPQLFLLLQKQHALVSTYDEQLQYWAQSLEVHASLPNNDYLRNAILLCANVDLPEFWISISKNAPDLCANLRIGSLCRAVCILEKLLPSKGGCFNSHDLKLMKIKLQNLCNKEKLSEAKAAVCIDLVGSEKAKANRPSLCKNILKDKKAEDVVILEFIHRFYWLFTDVSHQIVSVMLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD71</accession>
    <name>A0A183HD71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004662">
        <property type="protein sequence ID" value="VDO43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD71"/>
    <dbReference type="WBParaSite" id="OFLC_0000543201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000543201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000543201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000543201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="34718" checksum="7E6F069D9C7FF7B5" modified="2016-09-07" version="1">MPLTPSGNIDFDSLSPQQMQAWQRLHTFYLTSKPSAIDIFVHHMGTTINAHTGELTQIQTVVHVDTFILPLNSVIPSIGNGHLSMQSRTLNGVILQTQLTVAYSVQCKGALIGRNCDLICHEAVANTAIAVCQSNLTNFFYTCTYMKNGQVQNCLPCPWGITQDSYCQNSDGGILAPSAADVVSSSFKVATIILGILVGILLIFLIVTLIYSILMNRRARDNAPSYISATSGQNYRSTLRSEGGANRPLLQSTNNESHNQVRRAPTVAPRSIPQLDALPAKSSLRKGTPLSPAHLCAVSSLNDTLNSTLSSVPLPPSKEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDB8</accession>
    <name>A0A183HDB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gliding motility protein GldN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5480</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004733">
        <property type="protein sequence ID" value="VDO43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000547901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000547901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000547901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552489" evidence="2">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000547901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10693" checksum="1227B0B864FC36FA" modified="2016-09-07" version="1">MARINWLNFLLCIVLANNALAQDPKDSNDQLFDDAESVLGPEYAQFVAQLEQKPVHFSDDYNTPDSINLESVLNPETETGTNSNQWKDFDEKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDD2</accession>
    <name>A0A183HDD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TGT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5494</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004753">
        <property type="protein sequence ID" value="VDO43342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDD2"/>
    <dbReference type="STRING" id="387005.A0A183HDD2"/>
    <dbReference type="WBParaSite" id="OFLC_0000549301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000549301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000549301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO43342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000549301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45390" checksum="5DA8C7BBA4D8D5E7" modified="2016-09-07" version="1">IKDSAAFIALCGGHSSSHHERCAFAIGSIPKGCGFVLDVMQFAKRLRSLPKKSKGKKMSEVGATNTTTQLESTYCESSGNTGSLDLVITESEFDKDVIKNLLAGVWPYISPSHLRLVNGAFSPTEVIALTHLGVDLFDSSYAIFLAEQGKAFVCDENFPHEATFSIFDFTDTLYSEDFRPLCKSCNCYTCTHYTRSYLRHLTNTMELLGPVLLVIHNIQEYERMFALLRENLSRIFMHQKQVEKSSSGKESIRDLRLDKRFDWVGPPDDISKIRPVRLRRLTNETEQERKYREAREALNQWSSQFWAHHNILFEKKKAEFVEQRKKSLGRLEHSSAVDMSEFYRKFLDEQYNSLTSYNREWYYRNIKLFWPALKVQVIRFRRTLYKFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDL7</accession>
    <name>A0A183HDL7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5579</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004863">
        <property type="protein sequence ID" value="VDO43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDL7"/>
    <dbReference type="STRING" id="387005.A0A183HDL7"/>
    <dbReference type="WBParaSite" id="OFLC_0000557801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000557801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000557801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="156"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000557801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34443" checksum="E66E49121666EC50" modified="2016-09-07" version="1">MLSLGEYLGVKCHASIGGTNVRDDQRKLESGVHVVVGTPGRVNDMITRQSLQTNNIKMFVLDEADEMLSRGFKEQIYDVFKCMPNDVQVVLLSATMPSEVLEVTNRFMNDPIRILVKREELTLEGIRQFYINVEKEARLLSLIFCSICLVEWKFETLCDLYSTVNVTQAVIFCNTRRKVDYLAAQMSKEKYTVSCMHGEMEQSERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFITEADMRMMKDIESFYNTQIEEMPMDIANLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE76</accession>
    <name>A0A183HE76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine/uracil/thiamine/ascorbate permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5788</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005165">
        <property type="protein sequence ID" value="VDO44341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE76"/>
    <dbReference type="WBParaSite" id="OFLC_0000578701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000578701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000578701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000578701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4138" checksum="74A9AF5AC075A026" modified="2016-09-07" version="1">MRYAGWLHYLNAAATAAAVINAPQGCGTNWLPLLLPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEX7</accession>
    <name>A0A183HEX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6040</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005520">
        <property type="protein sequence ID" value="VDO45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEX7"/>
    <dbReference type="STRING" id="387005.A0A183HEX7"/>
    <dbReference type="WBParaSite" id="OFLC_0000603801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000603801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000603801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000603801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27259" checksum="3516B79F7DF70CD8" modified="2016-09-07" version="1">MVYPRSPTTTPIAETSVEIPQKKSPAKKRNHSMMSASQVRVTVLGTQSEPATQQIITESDHVLPIHGIAGLPKQSRMELADTVSGKDVVPRSGDEKPPWHFVRTANNGGSIIASQTMEDCSKNDVGMDTPSAQKPFAVQISNNSFSLPSSESLLAEPIGSSTSGSELSMMSSSSELTASQPVLAGNDGHLSESLREVIAQVDDEVATYAREAQYIRKLYFIKRLVESLVIVCYFKFLKIIFYIRQYVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEY5</accession>
    <name>A0A183HEY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vitellogenin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6047</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005532">
        <property type="protein sequence ID" value="VDO45216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEY5"/>
    <dbReference type="STRING" id="387005.A0A183HEY5"/>
    <dbReference type="WBParaSite" id="OFLC_0000604601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000604601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000604601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vitellogenin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000604601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26151" checksum="E6288CEEC7D0A833" modified="2016-09-07" version="1">MDSVAVFIERVPLHGLLPVSSLIQSYCTAHPTCGMEPTVQRIIRSILSKLPPGCQVVHQFEEIKEAIIILKSIGNIGHEEHSLSSLIDCIANDRIPKVVKIAAIDALRRKPCSDQRNSKIIELFRDQKENAEVRIKSFRQLMECVNDEILQIIVDQLHNETINQVGSYVWSYLNTKQRSTNPGSRNLQHLLKRFHIPQRFNLDSHRFSRFYELGYFDREVIIFIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFA4</accession>
    <name>A0A183HFA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6165</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005714">
        <property type="protein sequence ID" value="VDO45638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFA4"/>
    <dbReference type="STRING" id="387005.A0A183HFA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000616501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000616501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000616501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000616501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22542" checksum="20E6E174F189E3D1" modified="2016-09-07" version="1">MALRKHNGRLAQLKLLLWKNFLQQIRSPIFTALEFIVPLLLIGTTFGLMITLRHKYELSHQSTTFKPWIVQGSIIDLIIPPDFSKTFVDTIVDTQYLISGKTLNDDCIFLNVTRQFIDDNITANIDLEIVYTPTNPVIDKIMQIIQERYISWNLMEQLENDKLFGQLMKFGYFPKLDPKMALKISSTAKLTRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFJ0</accession>
    <name>A0A183HFJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3677 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005838">
        <property type="protein sequence ID" value="VDO45923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFJ0"/>
    <dbReference type="STRING" id="387005.A0A183HFJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000625101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000625101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000625101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000625101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17658" checksum="DA3727D396516DB0" modified="2016-09-07" version="1">MAPLLLCKLLMGTTDWNWQLVESFIDDSLHERQWADRPSADGLIVNIMTAFDTRIPHESMYTACDLIYPERYRTMAAVNRFAKVTDKEQKIDTFVMQMRDICERKGESAPRNLLKTMCICAGNANIRLLAARKMDSWLLNGKVWVLNDDNDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFW6</accession>
    <name>A0A183HFW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shugoshin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6377</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006022">
        <property type="protein sequence ID" value="VDO46376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFW6"/>
    <dbReference type="STRING" id="387005.A0A183HFW6"/>
    <dbReference type="WBParaSite" id="OFLC_0000637701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000637701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000637701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000637701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28226" checksum="0102C34841E049DF" modified="2016-09-07" version="1">MPFIIPSQQKETSTTYGQLPLQTDAIYPEDVSSKCATPKIAKTLSPIQLKRSNKLSNHRNLFKHMTLSKTFLSRATDGSDKMKIMEAVTTEDKEMLKREHSSPISFDRGKHSPMEAKARDESASIRSGEILEGENSKIVQEVGVNCFADKRRVKKKTLVRSLTVYVAASDEQSTSTPESKITLGKCGVDTKHNMDSPPVLVSNKPVLRGNTETSRLRSNRRPQLLKSQSVVDSRCEINGTYFCFCFCFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG39</accession>
    <name>A0A183HG39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6452</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006140">
        <property type="protein sequence ID" value="VDO46581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG39"/>
    <dbReference type="STRING" id="387005.A0A183HG39"/>
    <dbReference type="WBParaSite" id="OFLC_0000645001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000645001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000645001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552527" evidence="6">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO46581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000645001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40940" checksum="C35BA1196F16129F" modified="2016-09-07" version="1">MQAITALAHLRAAVLFIMDISETCDHTIEEQVALFESIRPLFVNKPVLIGLNKIDIVKRDELKLEKMEKLKKLEDDSLSMFELSTVTQEGIMDFRNTACNYLLTQRVESKLQSRKLTVEDGVLSRVFVAYPVPRDDRFAVSIEFQERPPFIPEAVVKKRILGSNNSSDEKTVGIRKLERQIELEMQDEYVLDLKKHYLLKNDVEKYDVVPEIWEGHNIADFVASDVKDMLESIRNEEEAKIQAGFYDEDLDLNDDETKKLFENAKKIVEKESQLKMASQAKKSITKPRLSRSVARKRDRNMMCLEEQFRDLGADIHPAQLKNMAKEQMREPTVKKIRVGKSPSLVASRPPSRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH10</accession>
    <name>A0A183HH10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006636">
        <property type="protein sequence ID" value="VDO47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH10"/>
    <dbReference type="STRING" id="387005.A0A183HH10"/>
    <dbReference type="WBParaSite" id="OFLC_0000677101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000677101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000677101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000677101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="47386" checksum="429E5AC6AF0FE8B7" modified="2016-09-07" version="1">MEICHYNDNSGHYDQYKRISEVLLDEMAQQSSITIPTTNINTTVATLTTTTISNQSKHPLKRSESRLNPEKSRSINIINNNDLYHYNDNNYKDLYHFYDPIYDPNDQYLPVKKYFSVDHFNPLIFETSQQRNEKNWSNHYRKQNFMNESFENCKLIPTEIQPISSQNFYSLDLLPGNSKKLKTNHSFECLLHHKNIPFYIWGSMSQQKKDDESYHSGRRKCFATMTDTCSCFNHSNYENDSDDDDNDNDNDDDDVNDEDDDGDVVVETDSILSEGRHYNKSKISWYNESENLKNNDSKHERITTRYEESRFDRAKFMASAAEKLLTADRNMREAQRNSILHPRIGRTRSLFNLFFPRKLLALEISNPVLISSTRSTEYLRYLPDVQSVDNGLNDVRIFVEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJA2</accession>
    <name>A0A183HJA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7562</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007984">
        <property type="protein sequence ID" value="VDO51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJA2"/>
    <dbReference type="STRING" id="387005.A0A183HJA2"/>
    <dbReference type="WBParaSite" id="OFLC_0000756301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000756301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000756301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000756301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6597" checksum="D40F464EB69665C8" modified="2016-09-07" version="1">MDLFNDILKQASSNTKNASKEIKKIDEACQKIEKSTNVRLATERKQSKIVKPPPEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJG5</accession>
    <name>A0A183HJG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008087">
        <property type="protein sequence ID" value="VDO51944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000762601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000762601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000762601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000762601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7500" checksum="566C08BB06A34EA9" modified="2016-09-07" version="1">MDLYLECAYTNFVNYIAECGNDHNAKEILIDGSFNYFIQKFFYIYALCRFSPCITRYCSVHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL28</accession>
    <name>A0A183HL28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009065">
        <property type="protein sequence ID" value="VDO54466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL28"/>
    <dbReference type="STRING" id="387005.A0A183HL28"/>
    <dbReference type="WBParaSite" id="OFLC_0000818901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000818901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000818901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000818901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21901" checksum="957A833B56340B14" modified="2016-09-07" version="1">MPTLNYAPLIQPILALFLHYMSESDAYACVVRILKHHSNYMKGSALASKAASYTLLTLVKVHKVAVYKALKNWIGSSDENILATALQSWPRWIFCALPFEHLICIIDCYLYEGNKILMRIPDDLTEKTCQQRIDLFVEKIIQSIRHGNISVTALLVTATRIRNFSNTKIARFQEKYEKMVNFILLFFCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM42</accession>
    <name>A0A183HM42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TSP1_spondin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8555</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009784">
        <property type="protein sequence ID" value="VDO56234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM42"/>
    <dbReference type="STRING" id="387005.A0A183HM42"/>
    <dbReference type="WBParaSite" id="OFLC_0000855301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000855301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000855301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF305">
        <property type="entry name" value="PROTEIN MADD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO56234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000855301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17114" checksum="A2061A3768F8F217" modified="2016-09-07" version="1">VRCIRRISRTGDAESTLILPDGQCPQPKPVDSEACGLIDCPAMWKASNWGQCSTSCGPGEQRREVTCEQRLANGELKQFYPPMQCRHIEKPPSVQLCDLGMCNSLSDSIFRESDNDKALSTMSTLMQQHSGHNRKLTLNIGGSAKLFVGTSLKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMG0</accession>
    <name>A0A183HMG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PHD-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS8671</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010007">
        <property type="protein sequence ID" value="VDO56834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMG0"/>
    <dbReference type="STRING" id="387005.A0A183HMG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000867101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000867101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000867101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15531">
        <property type="entry name" value="PHD1_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552577" evidence="12">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO56834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000867101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="40251" checksum="6C72BAE3DF57B50F" modified="2016-09-07" version="1">MTLILILNLLISWIAEDSDQEFEHLLKEHEKQLDEEEREKEERRAARARSAKKKGKKKKGEDGYERTDTNGNSLQTDHQDYCEVCQQGGEIILCDTCPKAYHLVCLDPDMEEPPEGRWSCPTCESTGVAKEDEEEKKITTNMEYCRTCKEGGWLLCCDTCPSSYHAYCLNPPLVEIPEGDWSCPRCLCPEPKNRPEKCLSWRWTEIVYPPPMTEEELKELEEQEGGRKIALKPPKKLPNRRERELFIKWKYMSYWHCEWVNEMVLDVHFTQFLRMYWRKMDPETPPEVDDGSQEDLQSGKIEKKEKENDPHNLEERFFRYGKISWRNYKDCDNSANQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN07</accession>
    <name>A0A183HN07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010394">
        <property type="protein sequence ID" value="VDO57808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN07"/>
    <dbReference type="STRING" id="387005.A0A183HN07"/>
    <dbReference type="WBParaSite" id="OFLC_0000886801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000886801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000886801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000886801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21051" checksum="3DEF763452C38D95" modified="2016-09-07" version="1">MSRFIKDMNEKGMAGLASEYRKIDMEDVPFGSHKAFVMNMAKNHVLCVDETRVVLKIGSAESGDYIHANYVLFPEFQNKFICTQGPLQTTKDDFWRMVFQERAETILMLCRPSEDGKPKCAVYWPENGDKLELSTVDVEKVGEENSDFEILFFKVQLKDEFKQSPSVSNKDPLVVKQYRWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNC5</accession>
    <name>A0A183HNC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Purkinje cell protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8988</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PKI family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010607">
        <property type="protein sequence ID" value="VDO58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNC5"/>
    <dbReference type="WBParaSite" id="OFLC_0000898601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000898601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000898601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004171">
        <property type="entry name" value="cAMP_dep_PKI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02827">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000898601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6630" checksum="F16A5A12BF33AE9A" modified="2016-09-07" version="1">MGEMDDVPQGSCKSGTNEEEQMESFMKSGRSGRRNAVPEVDIQGVDPDAAKLAERKKDTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNX2</accession>
    <name>A0A183HNX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9183</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011004">
        <property type="protein sequence ID" value="VDO59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNX2"/>
    <dbReference type="STRING" id="387005.A0A183HNX2"/>
    <dbReference type="WBParaSite" id="OFLC_0000918301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000918301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000918301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO59075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000918301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17313" checksum="5368793691BEA668" modified="2016-09-07" version="1">MYPTDHQRAIQSRSRHGRFGDMDFMSFNETVRRMFENLFRGLEQQYRQLGINWGSPWTSTTEYNFGSSVGQMVNDAEKFAMEMDVSQFHPADLKISLRHGQLRIEGHHKQQHDQYGFIERHFVRQFTLPDDVDETTMISHLKGSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPH1</accession>
    <name>A0A183HPH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ku_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9381</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011436">
        <property type="protein sequence ID" value="VDO60147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPH1"/>
    <dbReference type="STRING" id="387005.A0A183HPH1"/>
    <dbReference type="WBParaSite" id="OFLC_0000938201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000938201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000938201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku70/Ku80 N-terminal alpha/beta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000938201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20409" checksum="E2EED8C9DA9B9428" modified="2016-09-07" version="1">MSDEDRPAKRTKKISSHECTIILIDVGANMNRKGTTTTDMQLAKNVVEWIITRKIFTESADEFTLMLFGSDMTQNSVTNDENIFFCEEEMQRAKIDWLRFIDKEIKPSKLTNGDFLAALITALDYMRNHLENYPTNNITARNILLITNLVGCDENLDEECMRAVINGMKGLEINFNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQB3</accession>
    <name>A0A183HQB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Essential MCU regulator, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9675</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012126">
        <property type="protein sequence ID" value="VDO62371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQB3"/>
    <dbReference type="STRING" id="387005.A0A183HQB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000967401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000967401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000967401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000967401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7187" checksum="67E184DCDB25D2C2" modified="2016-09-07" version="1">AAQSCVWKRRTRSARVIDGIQIAQFPICLFGLIKIRQFLNAKEKCETIRYDAVKIEDDEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQU3</accession>
    <name>A0A183HQU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9851</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012538">
        <property type="protein sequence ID" value="VDO63902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQU3"/>
    <dbReference type="STRING" id="387005.A0A183HQU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000985401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000985401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000985401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000985401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6940" checksum="82A3C14C8DA16C0D" modified="2016-09-07" version="1">MDSPPKNAATIPSASAGDAAQRSQLKELDQWIEQLYNCEQLSENQVKILCDKVIFHFHFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRB1</accession>
    <name>A0A183HRB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10027</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012929">
        <property type="protein sequence ID" value="VDO65254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRB1"/>
    <dbReference type="STRING" id="387005.A0A183HRB1"/>
    <dbReference type="WBParaSite" id="OFLC_0001002201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001002201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001002201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001002201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6628" checksum="A3A87017EA4976E1" modified="2016-09-07" version="1">MDVPLNIDVSPIMRDASLLIPRPDTVPQRKSSILYPSVHSKLSPQPYIHHSTHDNDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSD1</accession>
    <name>A0A183HSD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variable lymphocyte receptor B cassette</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10393</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013810">
        <property type="protein sequence ID" value="VDO68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSD1"/>
    <dbReference type="STRING" id="387005.A0A183HSD1"/>
    <dbReference type="WBParaSite" id="OFLC_0001039201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001039201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001039201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001039201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5077" checksum="FDAF108AEB6CE60F" modified="2016-09-07" version="1">MGIFEATPQLQELHLGKNLLIEVPLALGRLFKLRYLDLSNNQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSF0</accession>
    <name>A0A183HSF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013837">
        <property type="protein sequence ID" value="VDO68233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSF0"/>
    <dbReference type="STRING" id="387005.A0A183HSF0"/>
    <dbReference type="WBParaSite" id="OFLC_0001041101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001041101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001041101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001041101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8496" checksum="21BC3D8D948302BA" modified="2016-09-07" version="1">MLIRQAAAFTYMDRRCENIIQKNKFYAEQINQMVGDYFFTCDSIWLADHMKNGNGKIYVYYFDQRSRIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSQ1</accession>
    <name>A0A183HSQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014074">
        <property type="protein sequence ID" value="VDO69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001051201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001051201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001051201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001051201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19941" checksum="222C3EEBE214FD41" modified="2016-09-07" version="1">MLLALLKGSPSKFRPDMISSEIFDSMNWRRPVHFGGSTNLDAFVTAYNLRYNRAEYLDALGSELCKRKIMKFVPSIPVKQQRLVRRMQQRRSGQEDMLDLETLKKAVDPDALRVQIAHRLGIKNFDSMLPCSKVRNNQDDKVGNKMQHIASAPFTVSPGIREPLSMEYIQSNKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSW7</accession>
    <name>A0A183HSW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014249">
        <property type="protein sequence ID" value="VDO69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSW7"/>
    <dbReference type="WBParaSite" id="OFLC_0001057901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001057901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001057901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001057901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4900" checksum="1C11B8BF309E71C2" modified="2016-09-07" version="1">MNNHSKETDDNDSETAEKTLVRKRKRNLLDDEERALALLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTZ3</accession>
    <name>A0A183HTZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10955</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015224">
        <property type="protein sequence ID" value="VDO72672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTZ3"/>
    <dbReference type="STRING" id="387005.A0A183HTZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001095501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001095501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001095501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO72672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001095501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="19125" checksum="F6A8CA68DB118121" modified="2016-09-07" version="1">MPETSDSIPLIGIYLTIVMLLTSISVIMTVMVLNFYHRGPLDRPVPEWVRVFILQKLRNFLKMNLQYPISNRDDLFVSNGQPRKICSREIIGLKSSQRSIRNQLEDQLLWWQETEFVNVDGCLTACKTKRNIDLQLRLHKILQVILFQIIVIEEFNYRNVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUG0</accession>
    <name>A0A183HUG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Progestin and adipoQ receptor family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11126</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015659">
        <property type="protein sequence ID" value="VDO74066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUG0"/>
    <dbReference type="STRING" id="387005.A0A183HUG0"/>
    <dbReference type="WBParaSite" id="OFLC_0001112201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001112201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001112201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO74066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001112201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13168" checksum="B8E3A369D363ED09" modified="2016-09-07" version="1">MTGTSTDKCIPNKYKLLRKTDLEPCFWINEHVHTGYRPPHLSTMQYVKWMFQWNNETINIWTHLIGFFYFTWRQYTANVHFLPATNANPTDHVIISVCLLGLQVTFSFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUX7</accession>
    <name>A0A183HUX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS11285</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016121">
        <property type="protein sequence ID" value="VDO75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUX7"/>
    <dbReference type="STRING" id="387005.A0A183HUX7"/>
    <dbReference type="WBParaSite" id="OFLC_0001128901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001128901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001128901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO75327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001128901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14739" checksum="18BD5A6EB888C26E" modified="2016-09-07" version="1">MAVASAAIGGSFQFGYHIGCVNVPAKIIKLWMIDSHKKLFGETLTLDEIGRCVRQTIFNWNYILKSFRAIAVGIFAVGGMIGGLGSGKMADWLGRKGAMIFNNVVAILAAVLMTIAYYVNVYPLLIVGRLIIGINAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWU8</accession>
    <name>A0A183HWU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11960</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017931">
        <property type="protein sequence ID" value="VDO80743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWU8"/>
    <dbReference type="STRING" id="387005.A0A183HWU8"/>
    <dbReference type="WBParaSite" id="OFLC_0001196001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001196001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001196001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO80743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001196001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13513" checksum="76580A8DFB24402A" modified="2016-09-07" version="1">MTRQNIIDDKGLIFGSPSSTSSSPPLIEPPSYDQNSNKNSSCTGCKSGELASAFCQNCTHFLCANCTLAHQYMHCFEGHRVDQLSQEDAAALAAAFAEKTACKCIQVMFGFHYLEHEHQIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX24</accession>
    <name>A0A183HX24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12033</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018158">
        <property type="protein sequence ID" value="VDO81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX24"/>
    <dbReference type="WBParaSite" id="OFLC_0001203601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001203601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001203601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001203601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="3965" checksum="FFAB6546387B24B8" modified="2016-09-07" version="1">MTKVDDRPHVAGAEITSNQGVKRHVLFQDIEDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX49</accession>
    <name>A0A183HX49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12061</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018229">
        <property type="protein sequence ID" value="VDO81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX49"/>
    <dbReference type="WBParaSite" id="OFLC_0001206101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001206101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001206101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001206101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9688" checksum="1F01CF0F2B556A79" modified="2016-09-07" version="1">MDQRQRKQFGSAGNLAIRGTGYTGHDNAPCHRLQNVLPSAGVMPQKTSAARRTTSTTTTTTKTTLRKSGSIGNVRNVITSSTPSTKTAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXH2</accession>
    <name>A0A183HXH2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="5">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12182</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01018578">
        <property type="protein sequence ID" value="VDO82594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXH2"/>
    <dbReference type="STRING" id="387005.A0A183HXH2"/>
    <dbReference type="WBParaSite" id="OFLC_0001218401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001218401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001218401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001218401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14523" checksum="D8F2210CDB15F699" modified="2016-09-07" version="1">MNISLLLEFVIYFQPWDEQLRERLLSLLTPMFVHRLCLEIKKLFMIDTTNNRFLISNQLKVFRGQIWNLRLALLENESPLKMIQRPLVIVTKRYHRYPTSDVWEECFKAKTPDYSGRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXI8</accession>
    <name>A0A183HXI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12194</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018615">
        <property type="protein sequence ID" value="VDO82705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXI8"/>
    <dbReference type="WBParaSite" id="OFLC_0001220101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001220101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001220101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001220101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="3807" checksum="6D9FBA6AC68C2CEC" modified="2016-09-07" version="1">IIVGLGPASHLEEYVSGSSCFGSSWVLDQPAILRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXQ5</accession>
    <name>A0A183HXQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12266</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018830">
        <property type="protein sequence ID" value="VDO83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXQ5"/>
    <dbReference type="STRING" id="387005.A0A183HXQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001226801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001226801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001226801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001226801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8091" checksum="9796A72945A4DA5E" modified="2016-09-07" version="1">MGPFIMIFSGLLILGVGRTMPYSLGLPLIDDNVKRQNLPLYFGGMFFIRMLGPFLGFLIGSIVNNYYYSFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY83</accession>
    <name>A0A183HY83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12445</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039845">
        <property type="protein sequence ID" value="VDP11334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY83"/>
    <dbReference type="STRING" id="387005.A0A183HY83"/>
    <dbReference type="WBParaSite" id="OFLC_0001244601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001244601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001244601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001244601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18120" checksum="73F9316538E77C24" modified="2016-09-07" version="1">MFGVEALKDSREFSETRFTDVTAVQGTITEKETFLANLGPLADLLDQYASVCNEVISLFAHVILRLLETINNIGSPVEVFTRMILVSKSKRLRRHSSICGTDDVSRITCCICFIHEKSILLQPCNHICVCAHCVEELLETYEEPLCPLCRSVITSYVDVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYA1</accession>
    <name>A0A183HYA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fringe glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12463</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039848">
        <property type="protein sequence ID" value="VDP11373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYA1"/>
    <dbReference type="STRING" id="387005.A0A183HYA1"/>
    <dbReference type="WBParaSite" id="OFLC_0001246401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001246401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001246401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP11373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001246401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21241" checksum="A39553833D446DCE" modified="2016-09-07" version="1">MLKYVIIFIWACHFDDDNYVNVAELVRVLKKLDPKRDWYLGRPSTMGPVGVDSIPEKATFWFATGGAGFCLSKSLLAKMSSYVRNGGFEELGEFLRLPDDVSLGYLIEHLLKVKLTVLDKFHSHLENLDEINKNDIHKQISFSAGGQPKIMKNVVRVPEEYIVEDDPQRFRSLHCFLYRKNCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYN0</accession>
    <name>A0A183HYN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039876">
        <property type="protein sequence ID" value="VDP11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYN0"/>
    <dbReference type="STRING" id="387005.A0A183HYN0"/>
    <dbReference type="WBParaSite" id="OFLC_0001259301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001259301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001259301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001259301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22393" checksum="9F3ECE26F49929D6" modified="2016-09-07" version="1">MSKSWPTSSHKVLQGTLHFLNEKEGGERDGYSDMEDSEVRFKSSRLLVIDTVSSHAILRVVTSFNHNSNYCNPVIAHIKTEIVIPEFVLCYVDLLCNLCNESFMSLVSESSGRRSSSHRNSRVARNLSLGYANSVDAGTSFIPSFSAAASEGVKLTVDEDNWAENTTVITGNTSEHSYSGLTERALVAPVGRVVARRCWIRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1G5</accession>
    <name>A0A183I1G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13577</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040272">
        <property type="protein sequence ID" value="VDP14113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1G5"/>
    <dbReference type="STRING" id="387005.A0A183I1G5"/>
    <dbReference type="WBParaSite" id="OFLC_0001357801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001357801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001357801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001357801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="707" mass="79207" checksum="05D5AC6C3AA6CF78" modified="2016-09-07" version="1">MTARSTYFCQIQTCNVILIIVGLTAIGLAASQFLGVSLNNYRKIDLRLLNWIYVLAGLVGLYTLFRNHGIVVAKTIHCLSIAVALYSIAFYCVTLFKIVHLHDANSQNEMQYRETKENFTAKLVICCLMIIVPTVACFAAFVAAALLDRVIVVSQPTWSHYSCDHNKKYRTNRLGLTALAATKLFLALCTLALAIFLEYEHQLISSKDPFVLIGLDHIAALLSVISAIVDLHSTVINRQPAANYKVAIGMAVIAAVWCLKSLDIEMYPYYYNDIQMWREVNAFIRNGTQILSIHDTANRIYLIIVVEGILVALFVLLFGLNLMSAIQASKCIQHEYYNENSMIKKSIAFQSRCLGSLHFICGLLLMALVIAGLIDVTWNANYVGADLMWLTVLLFATGILYITHSDSQLSAHFLLGFICFTCALEKMCSSINLTYQSATYPAFMNGPNDAFIGRLVLHCMQLAILSLETLTGFFSVVVYGNALRRRYRHKVKNSICMHLVLLLGNMFYGIVLVGCHISFTLTYWLFSESLVEIPFFRMGNGLLVFGISILQAISICYPALFLSVTILNVVAASVALFMISYAISNTYLLAVLLFTVEGLRWIIIEVALIFTACTTVACVICTFCSTFAVVWFLYTVHRDPTSSASTTVLCDENNYGTLRTLVSPQLQTPPVRHMEEQSIYWSTDENPYYYQASKRYYDQPYTIDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3H9</accession>
    <name>A0A183I3H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14291</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040742">
        <property type="protein sequence ID" value="VDP16356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3H9"/>
    <dbReference type="STRING" id="387005.A0A183I3H9"/>
    <dbReference type="WBParaSite" id="OFLC_0001429901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001429901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001429901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001429901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20264" checksum="D8E2B6728067FC51" modified="2016-09-07" version="1">MQLDQVDGSERDLMEVDPVRHRFPCCIVWTPIPLLTWLFPFVGHMGIATSRGIIYDFSGSFCVSEDDMAFGWPTWYRQVDPNTIDGGMEAWDRAVLDASEEYKGHHTLFCDNCYCHVALALNKMRYGHKRGYNCFQLASMILFKGRYVGIGGFIKQWFPFTIIILFTLMIIIITKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4C1</accession>
    <name>A0A183I4C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14583</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040974">
        <property type="protein sequence ID" value="VDP17728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4C1"/>
    <dbReference type="WBParaSite" id="OFLC_0001459101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001459101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001459101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF108">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="126"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP17728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001459101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47717" checksum="FBDBCCF1C3F3F83D" modified="2016-09-07" version="1">MLRKNHIEEMYQVNRLMTDALHNAEYFDVPICHPFCLLNEPVKLFWVNHVFPNRSTIIQVKTIMFWHLFNADNPHKLEILQNATVGLFEMSKEKNATKWINFDIFGDEIANREMLRGAYEVKTYDISVDDAFIMIQAWFRLSNIVSRKERLAQVFVETGPSISITSITNLIAFGIGYLTPTPQMSLFCLCTSFACLFDYIFTFTLFAPILYLTNKPDDGYVMAKKVPNNEFGEQCLTSYSKLICSWKGQFIAAAILVVLYSLSLAGVMKMKSTFEPAKAFPSDSISASSFRRLRSIFDEFFPLQVIINKPPNISDSAEHNEFYDMIRSLEAVPNSYGSNRTMVFLKQYEDFDRKMYSFLHILGMTNQESFTPSYDNLPTFLDHIHNPPFIKMRIDEKLVTLFNRHNIIQGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5A9</accession>
    <name>A0A183I5A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14921</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041359">
        <property type="protein sequence ID" value="VDP19596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5A9"/>
    <dbReference type="STRING" id="387005.A0A183I5A9"/>
    <dbReference type="WBParaSite" id="OFLC_0001493201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001493201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001493201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001493201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="44052" checksum="E852B0B5F7FEE39A" modified="2016-09-07" version="1">MSIVVQGEAPEPKKFRSSLPTQVIVEKPTFTYQSSGSPLDDAANGGQSPAGPSSARSSSSTCCIKEERERDDLCTNANSNSLLYPRNGQSLVDAFSTAMIFQATNAYMKKNNFPVPPGPPIPGAIAAASSPAAALFGEDDWSWHRNPAAAIRSVTQLSSCNNRMKTSVNSCSNGSGNILRNRAHDGCPSRNSFSSVRHHSAPVSTIVATSGKQSTHSVSSILDVLNARASVAALASGNGHLLQNPIAAIFNNPEQDNGNSAGDINNTQNASGNSSSIKNNNSLADVLTANLLMAASSSATANAAAIGRKWNREDRKQKEMEVKLALMLSASQLPVNIIENSFFREFMEYVQPRFSMPHDINYIEEIISTEHSRMIMNLKNQLTTAKKVAIMIDVLKLNTSTSAAAPPASIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5J8</accession>
    <name>A0A183I5J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041481">
        <property type="protein sequence ID" value="VDP20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5J8"/>
    <dbReference type="WBParaSite" id="OFLC_0001502101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001502101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001502101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001502101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14830" checksum="41FBDE450A4EA7BF" modified="2016-09-07" version="1">MLKHLPRCPEKTRDAASLASVHRSTSHQSAKKLNYVHGCHKNTVREFSRQDHYEATDEIEKKECVGVMSVAINQSIMLGWVEWQAGRQLSSLSLWRREKEAEKRKEIRGAAWNSGESRRGNGSGGITGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6E1</accession>
    <name>A0A183I6E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BH4_AAA_HYDROXYL_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS15303</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041920">
        <property type="protein sequence ID" value="VDP21253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6E1"/>
    <dbReference type="STRING" id="387005.A0A183I6E1"/>
    <dbReference type="WBParaSite" id="OFLC_0001531401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001531401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001531401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP21253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001531401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31950" checksum="35CCAB96490A93B1" modified="2016-09-07" version="1">PWFPKHISDLDKCYHCIVKYEPTSDPRHPGYGDEAGDNLPNIEYSPEEHKTWETVFKKLKSLHHSHTCFEYQQNFQQMELEGLLEPTRIPKLSLINKYLQRRTGFTLRPCAGLLSARDFLASLAFRVFQTTMYIRHHASPHHSPEPDLIHEFIGHCPMFADPFIAQFSQQIGLLSLGATDEQIEQLATLYWFTIEFGLCRQNDQLKAIGAGLLSSYGELMHACSDKPQHEAFDPQRTALQPYEDSDYQPLYFVADSIFDATIKLRYRFIKLKFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6F1</accession>
    <name>A0A183I6F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041937">
        <property type="protein sequence ID" value="VDP21296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6F1"/>
    <dbReference type="WBParaSite" id="OFLC_0001532401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001532401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001532401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001532401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3676" checksum="1F141022DC66A52E" modified="2016-09-07" version="1">MVPTMNGPGRVIIYIFLDMMSSMRQVCVKFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Q9</accession>
    <name>A0A183I6Q9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15421</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042106">
        <property type="protein sequence ID" value="VDP21786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Q9"/>
    <dbReference type="STRING" id="387005.A0A183I6Q9"/>
    <dbReference type="WBParaSite" id="OFLC_0001543201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001543201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001543201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001543201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12289" checksum="3BED9230E443C184" modified="2016-09-07" version="1">MENVYANYTHRDANLQLHKLSDDGLRNNLMEEKYEAEIRKLNREMQAYRNTITKLTAKHDGYNHVIQLFESKLQLMAKHVENLQNKSQLKISREILHKVLQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6T2</accession>
    <name>A0A183I6T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042157">
        <property type="protein sequence ID" value="VDP21912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6T2"/>
    <dbReference type="WBParaSite" id="OFLC_0001545501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001545501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001545501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001545501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9217" checksum="A93F9FF013976557" modified="2016-09-07" version="1">MMFLPWMCLMNTRMLLPTGRLLRNFKKNLMISNAASEIYGNSLSKTPVIGVHQIVYNYSWIILLVWKRFIVLLKRLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7P4</accession>
    <name>A0A183I7P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF4276 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS15756</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042791">
        <property type="protein sequence ID" value="VDP23676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7P4"/>
    <dbReference type="STRING" id="387005.A0A183I7P4"/>
    <dbReference type="WBParaSite" id="OFLC_0001576901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001576901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001576901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP23676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001576901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24607" checksum="9034BF529F8EA3D2" modified="2016-09-07" version="1">MKPKYNMMFLLTVGGKFNYQGSRQWLEEHIDKQTETNIELVLCLDSVGKDGGLIAHVSKMPSETSSVGRFFSLLKNATSPNRTIEIISKKINLNADMLAWEHERFSIQRLPALTLSHFKSHTDFGRNSILDTPSQISMEVLEANVRTIGEALLVYVLNLPNTKCAHEENISTCSILAPGDVNKKRLSTWLQQFGSKSRSLAANSEWLVANLRDTVVRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TWL6</accession>
    <name>A0A3P7TWL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000206">
        <property type="protein sequence ID" value="VDO26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="129" mass="14730" checksum="49A44CB277A9542F" modified="2026-01-28" version="1">MALLAAIEINWTLDSLANDNDACGWMFVADAIRGHLAQQVLLKCVKDTSDRYNSLRGYGNCPFGLYPDIPDGSVGGREERNVEVYPTHIIISSYFFDMIIIQENVIREKNTMHRLRKTITEMMKIYTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TY04</accession>
    <name>A0A3P7TY04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000276">
        <property type="protein sequence ID" value="VDO26876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZS4"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF2">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="477" mass="53529" checksum="6E96E130AECC74E0" modified="2026-01-28" version="1">MEKLKCCVQTYEWGKKGVASEVARVYAKGNPDASIDDKISYAELWMGTHPDGPCHIQRSQKKLSQYIAEYEASPRRKVSAERHLPFIMKLMSIQHNLSIQAHPTKEQAARLNDRDPIHYPDRNHKPELAYALTRFELLCGFRPAQQICANLEAFPELKQLMGEDTSHAFQILVRAEINEECETLKFALAVCFKKFMKHAKDEVKSLLDSVLTKLICGIRGSLSEETVAVIQKMARDFPGDIGCFVPLLLNHIVLSPGECCYYAAQELHVYLSGECIECVSCSNNTIRAACTSKFIDIDTLCEILNYRMTDPSYYIVSPTVLKNFPHIRVYDPDCDDFTLHEVKIPSSPPSSGTAKACPVFIPSLECGSIMLVVEGEGTIESYSVKQKAKKSLGVRRGDVIYIESCVQLCFAECSRDILAYRTFSYEEGPDHLLNSTDGTTVSETTRITVPMKGRINPLVIDDDADMFDIENEMDGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UJS0</accession>
    <name>A0A3P7UJS0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001999">
        <property type="protein sequence ID" value="VDO35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UJS0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37918" checksum="F9F529926053A96B" modified="2019-02-13" version="1">MLSAFSFKLNDFEISGQTSNETDKQILLEKERRNSEYWTDESANESSSSNADSSIESGSRKSGSLSSSHPPAPKKALMSPSENFVQSDFGATILPSQNQDRPFTSKNPLYMTQSQTSLVSYGEQEDEEDQFAKADRKAVANKQTERKGSSESTNREPKPPPGHEDSRSPDEIAVDSAVEEGLRELERHHIDQNLGSLTPKSAEGNDSPQILDEPVEIRLPPSPPTKCSPELEARFRGFFEKKAQGADLNALIQKRRDFKNPSMYEKLIEKFEVDELGSNFAPSVFDPHGFTKDCFYDQISALQKEAMEKYNATIEKKISGTATAKATEAKRKSRFEGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WXU7</accession>
    <name>A0A3P7WXU7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS7686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01008196">
        <property type="protein sequence ID" value="VDO52184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WXU7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO52184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="162" mass="18085" checksum="FF5FE42D7E06A77E" modified="2019-02-13" version="1">MFLICSFISRWCHQTIENNYLRRLLPGPVTLIFERSILLPSTFNPEHGTVGIRIPDHDFVRSLITRLDDVPLAQTSANISNDQINPVCIEDFKDLWSELDLIIDDGVLMCPNSKMDCKGSTVVSLSIPGTYSIIRDGCVRTTTEEKLRDCGLVALSDGDCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XYU4</accession>
    <name>A0A3P7XYU4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001818">
        <property type="protein sequence ID" value="VDO34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XYU4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="7">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="221" mass="24928" checksum="F30DA77308AFD166" modified="2019-02-13" version="1">MQSVIASSPLVKDYKFDVKNNRWCIITFQLPLNTKTKLDVGALVERELENFLVWETPGIEKCIVRCENRGDDQYQVLATQGINVQALMKHSDVLDVNTLYSNDLNMIYNNYGIEACGRALVKEIVRVFTPYGIDVNWRHLTLAADYMTFTGRIQPFSRGAMSLSASPLQRMTFETTIAFMRDALINGDHDHLVSPSSRLVIGGLLRGGTGIFDLMLPKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZPR4</accession>
    <name>A0A3P7ZPR4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007952">
        <property type="protein sequence ID" value="VDO51475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZPR4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="199"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO51475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="358" mass="39506" checksum="28A17CDEE51C6860" modified="2019-02-13" version="1">MNGCNFAGPNSLSIKENDSAEFRVEITGKPKPTVKWSLNGRELSPSLDSNIIIKSFDEVYTLKIEKANVKHAGEVVVTAENSAGMIGKEVVLKVEPDLMKPVFKTHLIDRSVNEGEPLRWDVSIERPYKGVTVKWFLNGKELTSSENVQISDDGEGKYHVTISEAKPEMTGTLVVKATNSCGTSESHASVEVKPFACKPEITRPPQDHIVEENETVKFSAIVTGKPTPTVSWYMDGKKLENNTEIGVKFDESTGKTSIKIFQAKLSDSGKKITLKVENTQGQVEANAMLTVNKKSEPPSIVSEMKSRQVNEGETVSFSVKVTGYPPPEVTWFHNGEPIVPDGYVQTFCTKKRNDQIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AGQ1</accession>
    <name>A0A3P8AGQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040148">
        <property type="protein sequence ID" value="VDP13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0R9"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="96" mass="11100" checksum="2466E29BB77D9818" modified="2026-01-28" version="1">MSENVPVESEEKSRKKPGRACDHIRQALKRCLKESDCIQKEHRHAMDCLRSHADTVPIRCFQLLDTFAQCKLSLIDNRLRTRGRKLDIPDAEVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B781</accession>
    <name>A0A3P8B781_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040072">
        <property type="protein sequence ID" value="VDP13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0B1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="113" mass="13007" checksum="9509433B3288F1A1" modified="2026-01-28" version="1">MEEKVVELTHNWSADQWDWPLQHNDDVVKVTNTNDKFEVGLDASFFTPKEIEVKVAGDNLVIHCRHETRADQYGEIKREVSRTYKLPSDVDTKTLTSNLTKRGHLVIAAKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BYB5</accession>
    <name>A0A3P8BYB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039832">
        <property type="protein sequence ID" value="VDP11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY14"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="551" mass="59442" checksum="183BD5102ACDBFD4" modified="2026-01-28" version="1">MASAGEGLLAVTGKRTSGQSVRTQNVMAASAIANIVKSSLGPVGLDKMLVDDVGDAIVTNDGATILKQIEVEHPAAKVLVELAQLQDEEVGDGTTSVVIVAAELLKSADELVKQQVHPTTVINGYRLACKESVRYMQDNLSFGSQELGRHSIIEAAKTAMSSKVIGPDAEFFANMVVEAAELVKVTDAQGKVTYPIKAVNVLKAHGKSVRESFLIKGYALNCTIASQAMPRIIHNAKIACLDFSLQKVKMHLGISVVVEDPAKLEAFRREEFEITKRRIEKILKAGANVVLTTGGIDDLCLKQFVEAGAMAVRRCKKIDLKRIAKATGATLMSSLATLEGAEAFEASQLGAADEVVQERISDDELILIKGPKARTSSSIILRGPNDVMLDEMERSLHDALCVVQRVLESKKLVAGGGAVETSLNVYLEAFATTLSSREQLAVAEFANSLLVIPKVLASNAAKDSTELVAKLRAFHNKAQQVKELAHLKWAGLDLENGEIRDNKEAGVLEPLMSKVKSLKFATEAAITILRIDDLIKLEKPVQRRNDDDDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FMG5</accession>
    <name>A0A3P8FMG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043112">
        <property type="protein sequence ID" value="VDP24479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FMG5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="101" mass="10751" checksum="8F7683A177EA5274" modified="2019-02-13" version="1">MFGNYTEIDFQASPRYNDCGQHAVYHTLGGSGGGGHPVVPQLTLSDDGDTLCVRSGSARGSIRMPSKQDHQVQAGPGSIRMPSKQDHQVQAGPGNFNQLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXV4</accession>
    <name>A0A183GXV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome oxidase c subunit VIb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS64</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000015">
        <property type="protein sequence ID" value="VDO24384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXV4"/>
    <dbReference type="STRING" id="387005.A0A183GXV4"/>
    <dbReference type="WBParaSite" id="OFLC_0000006301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000006301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000006301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO24384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000006301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21465" checksum="F96C187EB00C6073" modified="2016-09-07" version="1">MGEKWGKKENERRKDKYCRPWVTEKNIADMSDESVAVPETLGTRLEHLKKKYREYKTRQPDAPEWFSREYNEKQRGTEDGILWAAPNDVRYPQCKATRHCFDYYVDYHRCIALLDIKHESCNFFRNVYMDLCPSEWVKLWDEQIKQGPVYGANSEIHSTFPNIKPPVKELLLNNYGNSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXZ6</accession>
    <name>A0A183GXZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS106</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000025">
        <property type="protein sequence ID" value="VDO24554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GXZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000010501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000010501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000010501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="3">
        <location>
            <begin position="581"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="781"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO24554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000010501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1701" mass="195860" checksum="A39A739E5B98C3CC" modified="2016-09-07" version="1">MNSTIRYEWGIIVFGESNKQRITHEMMRYVICIDYQRLWYKAVLLEYSFADVFRQNSSKLGLNLVHSPSFLFTKNVAMAQREVEEWYEELESGKDEILVVFFNDSDSNEVEQEMQGALKDRILLYVQSGDNLLRCARDETDEIMRCWIKEIRELLSERLYGASSTEKLGSEDAGGADSIKTNNSEAIEQKKLSSGEFPIVFLYFIVIDIFISCGENQEKHEININCSLLGLVHVENILADLQKLEKPLKDLDLIKNIDTSMLHNRLLIPFTDREQNGRLLALLSAASFTKLPDLQTAVVNFVENILKSGLIFNFLRVYSPETDLKINIFSYLLYFSFISFMLRENAYYIRNVASGECHRTLFTHLQDIMQILYIAKVNHIQDFDIACDEFLNFMELIPEKCWSATDEELQLTIFRMLQKLTVYFATTNASEFLTVDLLEDHELNIISNNMKADLHKDHELNIIYNNVKCFDNRVSFDLVKECGFKDYKPAWFNVDVEPPEDFRTLSVYATSNDILHPARPYIRKNITKGSYLSQEHYLDVQFRLMREDLVAPLRDGIRLWKQQKGKETFLSYAMDPSEELDLLVIRGVIVEGAQLKRSTGEIIRYVTFQPISTDNSWSLRLKYGQLVALSSDGFQNEALFATVAEKDSDDFSKGKLGLCFFDDHSISRAKVYTLVESNSYYEMYQHVLECIKRFDNEHQIPFGRFLLKTERDVRFPPYLVKQIDEDSSSSSDSLNSEYTDYSGSRSLTKRTLIAKEISIFGTKYVVDKLKYTLDGDKVGCLDDAQRNALCHALTHEFALIQGPPGTGKTFLGRLIVRILLENINMWNPARTNPILIVCFTNHALDQFLDGVLVDLINDGRYNDELPSIVRIGSRCKSETLQRYTKRPVLEAYTNLISDIARHKANQLMLERIHLLEMIRSEVAVLTLRKNEILSFEYIQRAMLPEHIRQFKLQRQNNGKKCSADEIFCRWLLEGDPGREDRVSEETDMNEHIIDYEREKFFENKDSPQKSILWSMDETFVKTERNEQKEEMLGPDPKIDEWITWKEIQERLLKTNPDVDNYYHSGQWDIDKDPNASAIKPVTIFSDQMCGKSKQHINAKCNAELITSLNDVKTNILKSPPLTLEEASLIKNLQTLHRHRRWALYMHWIDKLKTVVSKKLDTLLCRYQILMKDVKKEFDLLDEIILRKALIIGATTTGAAKIKPFLDRLSCPIIIVEEAAEILEAHVLTSITNECQHAILIGDHQQLRPNPAVFALAREYNLDISLFERLIRNDFPYVTLRKQHRMSIAISKTIMPEFYPLIEDADNVLKYPDVRGCQKNLYFINHLQKEDVFLSTSHKNSFEGDFMVSLSAYFIQQGYACSQITLLCTYTAQANYVRTQVMLKFSDESSFPLVETVDNYQGKENDIIILSLVRSQPSDNIGFLKVSNRVCVALSRSKLGLYVIGNMHFLRSNSLFWNRLYIALADANCIGDGFPAFCIKHNVTQVIGIGNTQLIRFKKFIFLKIIHSADEFLTKTPEGGCYYPCDFIRPCGHICSQPCHRTDQEHNRACIHSCPKTCSTIFRHPCTKLCGESCGACQFYENKIFPCGHTTGVVCHLFEKAVCQQKCPKKLPCGHQCVKKCNEPCKCSHKILLICGHPVTTACSEKQKTKCVVKIEKTFTTCSHRWTVPCHDYENAQCGAKCERILPCGHRCQSLCGNCTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY05</accession>
    <name>A0A183GY05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS115</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000028">
        <property type="protein sequence ID" value="VDO24603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY05"/>
    <dbReference type="STRING" id="387005.A0A183GY05"/>
    <dbReference type="WBParaSite" id="OFLC_0000011401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000011401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000011401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000011401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8679" checksum="4950B5D72E82495E" modified="2016-09-07" version="1">MTIILASSTEENEKVWLCQLYESSSLLTQLGALVYKDVEKLLSNEVLRVNGSNVQQLIPFFEILSTNNRILSNTCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYJ1</accession>
    <name>A0A183GYJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000088">
        <property type="protein sequence ID" value="VDO25315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000030001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000030001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000030001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000030001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30976" checksum="7323A08098A20A19" modified="2016-09-07" version="1">MDGCRKALYSYSWQQSPINKRRRVNLPDEEKKIFDDWFEEKADEYVPWIRNHGSDHENVHANDFWMTSLSPCNPEIHKILVRVSPRILEPLQRPKQDRKTIKEEMHKETERLTNIIRYEKSLKGTRKTIDVIKKEKRKKPIFFQTQQQRLFDSTVFREYSTCIASDKLSSFREELCDMSECAKQTASSESKQRTPEHHNDNSDNELLRLALESSPISKSDSALKVASNEDELTDEALLAMMLSSPASNPKLKNNRWSADLCQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYQ0</accession>
    <name>A0A183GYQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS360</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000112">
        <property type="protein sequence ID" value="VDO25518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000035901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000035901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000035901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552307" evidence="3">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO25518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000035901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28992" checksum="80FB422B28D38A87" modified="2016-09-07" version="1">MKPALLFLAFNIIIITINVVKGENCEDSNNNCQDWVTSHASLCHTTDYIIKTCRKSCGYCKGKCALTRLAFSLFLAGFDVSRVPSHLQSIAWLIGIWQSNHGGKAVFPTIPTFTYGEQVEISLSDEHMTGLEALNYTAFAWGSSKQEELHSEYGYITVNSSTRIVSLTTVMNNGKFPLHAVSSLLTKISCFVTVEEGIVEPNRIEFHLKDIGRISFSRDLPVLQLVREWTLLDKNTLQARLNMETLTHGMQEHTKIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZR5</accession>
    <name>A0A183GZR5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS725</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000271">
        <property type="protein sequence ID" value="VDO26840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZR5"/>
    <dbReference type="STRING" id="387005.A0A183GZR5"/>
    <dbReference type="WBParaSite" id="OFLC_0000072401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000072401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000072401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000615">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="156"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000072401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="35987" checksum="38FFCDA99F41A537" modified="2016-09-07" version="1">MAEQMQLKGTLKGHNGWVTQIATNARFPNMIISSSRDKTIIVWKLDTDDLAGSYGAQLGGKAERALKGHGHFVSDVVMSSDGQFALSGSWDKTLRLWDLTTGVTSRQFVSHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAQCKYTVNVGILDEDCHTDWVSNVRFSPSSSNPVIVSAGWDKIVKVWNLANCKLKTNHIGHTGYINTVTVSPDGSLCASGGKDGNAMLWDLNEGKHLYTLGGNDVINALAFSPNRYWLCAAVGPVVKIWDLEDKKPVDELKLDVMGGAKSAPPQCISLAWSADGQTLYAGYTDNVIRVWQVSVAQIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H013</accession>
    <name>A0A183H013_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Divalent cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS823</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000327">
        <property type="protein sequence ID" value="VDO27219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H013"/>
    <dbReference type="WBParaSite" id="OFLC_0000082201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000082201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000082201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="185"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="395"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO27219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000082201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61517" checksum="38BC524B74DD69C7" modified="2016-09-07" version="1">MKTLKIIHYRIEVQQNTLSELLSQVKRRRFRSENKEETNVAMIDSKLDGLRANFELNSMAASFDGPLWCKHEVTGSKLSSDVVADSIPMLRKMGEVLNSKNAKGESNLAFSSGDSIQAASDEDFSFTHANVLDSSLSTASSCSLFLQILFPFVPAGLGMVLAGFVLDIVQHWNLFVEVPETFILVPALLGLKGNLEMTFASRLSTLANIGRINSRLQIVIIANLALIQVQAIVVAFLASGFAVMLAWIPKGQIDWSHACLLCASSLATASLTSLVLSMAVICVVLISRNFAINPDNIATPIAASLGDLTTLGALSLLGSIFLQAHLNETWLNVGVIVTFMIATPFWTYLARRDEDTTDVLENGWSPIIFSMLISSAGGFMLESTIKQFPKIAVFQPVINGVGGNLAAIQASRLATFYHQHYSFGTLTEDLLRHFSFKRAFLSDGKCRCAFSSCVIIICGSLPYLLQLGHTDFAQREYSTIWTIFYWHIYFCSINTGSFQVLLLLYVCQLLVAFLWSLEVDPDCAAIPYLTALGDLFGTFLLFLIFASLSWFSQDQDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0B8</accession>
    <name>A0A183H0B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS928</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000380">
        <property type="protein sequence ID" value="VDO27603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0B8"/>
    <dbReference type="STRING" id="387005.A0A183H0B8"/>
    <dbReference type="WBParaSite" id="OFLC_0000092701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000092701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000092701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF4">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="507"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="594"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO27603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000092701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="724" mass="80850" checksum="9658603A4A7D67C8" modified="2016-09-07" version="1">MRKDGIGLQKIMSGEFSTRGGGIHKNFNSHRGGSMSRGRNRSKFSTRGVRRGGISPKGGGDHNDLFSRGRGFGKGDRGRGGHGRSDQGRKGFSANNGGGIDFKKRMSFDIDNRINKEQNSGDGKKNENKYKKSMSEPSTPATGKFKKYEMDSEHDEDEDMSISDMQDEEITTKTSETIAADMTSKQRKALTPKNGSNFTQIMSAKGLSKMKGALKREKDMKGDKELVTSREVKKAKMTSVESEEDDEDDSDDEVDEDKVAKKNVNSVAEIGESDEYEDEESLEDEDEEEVPSEVKPALASTPGSAMHLKSALKTPGTGKSSKKVSLSATTATTPKTLLKNKPVTPHPQTKSSKNKARRLKFEESDESDEYDENDDEKDEEGFKLDDRGMKVMQSDDSEDEDEDEEMTDDDEGESDEEKGINNAKRSMTDTKQERISETIQNKKDRVTLKELHSKNDKGTKDKANVVANKEETKGIKRKCEDGPSLKLEDAKEVIKEEQKRREERDKKSLFVRGLPKDVKLGQLKALHNDILYVRHMPHRNFAWLIFASEKLCEKAYEDISKQTIEGRTLTVDFCGAKAKTRPQKDRSQLPINPLELFVGGLPPSTSKDQMKVIFRQATNISFPKQARNKNKLYCFVQFGNEKEARAAFEKGKTLKINGIPVDVLYARIRKGITNEAKLPKANQDSDLSNGIGTKSGIKNLPKRNEVNGDTSEGIESSEEGIEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0H3</accession>
    <name>A0A183H0H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS983</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000407">
        <property type="protein sequence ID" value="VDO27784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0H3"/>
    <dbReference type="WBParaSite" id="OFLC_0000098201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000098201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000098201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000098201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9460" checksum="3B304A7ADBF4F286" modified="2016-09-07" version="1">MKEKKDKNQLVKREVFENSNSPLEVNLEKKDDVNLKLTNIGAERRSKNKDEKVDEDDTLFNIDPVMPDMDLPSLRLKTKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H145</accession>
    <name>A0A183H145_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase omega</fullName>
            <shortName evidence="6">GSTO</shortName>
            <ecNumber evidence="6">1.20.4.2</ecNumber>
            <ecNumber evidence="6">1.8.5.1</ecNumber>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1205</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="6"/>
    <dbReference type="EC" id="1.8.5.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01000533">
        <property type="protein sequence ID" value="VDO28654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H145"/>
    <dbReference type="STRING" id="387005.A0A183H145"/>
    <dbReference type="WBParaSite" id="OFLC_0000120401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000120401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000120401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="149"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO28654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000120401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32852" checksum="3DD1D7D2F97B653C" modified="2016-09-07" version="1">MTQVNETVNGGSIYEVFSKIPIPNQQGSYSPVENAALLLGSRSINIRGLNSPTLHQDSPEPYSGLGTIRLYSMRFCPYAERAIIYLAKKRLPTEIINIDPGNVPKWFLNKSPLGRVPAFEMNGIIIYESSVIAEYLDEIFPETAILPRNPLAKANQKILVERLSPLISTMFKTLHPNNATVQQNVDKLLHKALRTAENLLKDDFYGGKTLGFADVMIWPFLERLQLVTVNPYTEFRYFPGIYYPKMGAYMARMQKLPEILFAQRPIDQHAAYVNSFLIGHPNYDIGINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1B1</accession>
    <name>A0A183H1B1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1271</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000572">
        <property type="protein sequence ID" value="VDO28917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1B1"/>
    <dbReference type="WBParaSite" id="OFLC_0000127001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000127001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000127001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="130"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO28917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000127001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29367" checksum="E9229CD75B792A3A" modified="2016-09-07" version="1">MTLMFLFHYCIVGNIDSKHIAVDDVLSGQFKQHAKEWTANKQLRHKYTSKDVTSNTLTYDETTLNSLKTIPNESCIATAFSTIKLNHTTHSTAQLYSSRIEENERETEDDRTEVVGQQMPYVFQNRQLTGCTANPASSIEGLVSFPDSQVMIRKGHIGPAVLAFTNNYKKPVIWALKTNAIRRLVAFPTVGIIPPSETVQIKVDLIEQIPRKVLKDRLSLEYFVIDQKVISENNYNNFFHHNKSTRMKKSLEIVYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H223</accession>
    <name>A0A183H223_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF725 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000737">
        <property type="protein sequence ID" value="VDO29893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H223"/>
    <dbReference type="WBParaSite" id="OFLC_0000153201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000153201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000153201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000153201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36979" checksum="87851310EB683936" modified="2016-09-07" version="1">MQCIKNTVSANYGTFETEIREHKRRAIKTCFAQTIAEGNQKNRCVLALSDLESKAWDRNGPLRDCSICRTFANGAIKAMLSTSAEEQKCVRSEVSKAITIEAEYCLRTKNSSFGGIPELPDFEEGSYAFKDEIINSVSDYILTYSRLAFCNERKPGRAEATRKCLKNPFDGYLEKHCDALKNCEKQIPEACQARTLLMKKATCECVELTRSELKKRLSSIAQAIRDAADSNDRGAASIGSGSKVDQCVGNIKSLVRTPTSDWIEVIDKALEKCLKKKPAGQNLGLDSLVNVGCRKVIADTTGTAHIQLKAGFDFINNLIDAMVDRAGRFCGGVQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2C7</accession>
    <name>A0A183H2C7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1637</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000814">
        <property type="protein sequence ID" value="VDO30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2C7"/>
    <dbReference type="STRING" id="387005.A0A183H2C7"/>
    <dbReference type="WBParaSite" id="OFLC_0000163601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000163601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000163601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025224">
        <property type="entry name" value="CCAR1/CCAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045353">
        <property type="entry name" value="LAIKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304:SF11">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19256">
        <property type="entry name" value="LAIKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000163601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="78853" checksum="91C826EBBFD4701A" modified="2016-09-07" version="1">MAEIRYYRAEKDRMDTCCLFLPDTSGLMPTEDCYQQLLATLKDQLGNKLAAVDAQKLVLPSTVAATTTDSGEAGEGIATTAEPAAPTGDIQQQLQQEQQQIDANKEQVQEVEEDDEDLNPTHWSKLDIKTMKVAELRQELMARDLETKGVKSVLCNRLQEALDQEKAKDDDKRDKVEVVKPKEEKMEAKELTDEDKKAVEKFVCFEEKEKKEKKASLERHFTIPKELGILVYPNRLAKGGKFDCKIVSLHTMLDYRTEDNKEHSFELAVMAECISEMLDRSQAFVAYRTLNCAIDKESEKKRREEAKLAEIVGTEETTENAKGDKIEKSEEEKKKEDEKREEEQRKFLAEARKPIIIDRAVFQAFAHFDQNLCGYILEKDFEEILYSIGLNISRAQVQKLLKRYLSRDRISYRYLTDSWANKDGTVTYRPGIIADPPTTEQLAKGNISKESIDTNKKATNETPDINTTGSVMYLGSFMNIPQILEQVSRMETDYNAALQKVDVLEAQLKDGAKHVQVLEKKKKRLEEDVEKYRKRLHDAEKCLKNSVDDTVQMKSAIQEFRRIGERMIGMAEKLMPNPKEDEKTSEKDEKDMKKEKKDDKDEKKIPKKKDSLPAKINGEAEEKKELQLVDEVGGNDVGDEPMESDVIVLSEEVTGDEEKDVKKETLSSQNTDSTTGTVVTDAYITLFSQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2E9</accession>
    <name>A0A183H2E9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1659</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000828">
        <property type="protein sequence ID" value="VDO30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2E9"/>
    <dbReference type="STRING" id="387005.A0A183H2E9"/>
    <dbReference type="WBParaSite" id="OFLC_0000165801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000165801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000165801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="12">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO30347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000165801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18556" checksum="00E59C3104F94CD8" modified="2016-09-07" version="1">MERLKISDWNSLEGLKKQVCSNCGRKRMYFCYNCKVYMPDVEKLVPRLELPVQIDIIKHPHEKNSKSTALHCLLLAPSSTTLYESSNAPDYNFPNYEKENTVLVVYSEGALSVDEFIEKRGPIGRFVFLDSTWFQVSFCNIVFGYYSLIIVSRSSEISFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2J0</accession>
    <name>A0A183H2J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1700</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000853">
        <property type="protein sequence ID" value="VDO30493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2J0"/>
    <dbReference type="STRING" id="387005.A0A183H2J0"/>
    <dbReference type="WBParaSite" id="OFLC_0000169901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000169901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000169901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO30493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000169901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="73397" checksum="EC0D0EAA68868D6E" modified="2016-09-07" version="1">MIACISPSDCDYVETLNTLKYANRAKDIKNKIVANQDKSSKLIGCLRSRIAELEAELLDFKQGRITVSDGIESFNDQYRENVLLQADVSQLRIRVKALQETVEMLRARNVQLLAEKVEVCARMSISESQNQHVFIESTRNKTGEHEGDAFGSTVRVYLDELESLRCALMESHATNEQLHQQVNRWKAMVANNTKRMPVDDLANHAAIINDSLSNNAEGVLISTPIFSLIQEAKADIKRMKQNITGNSLEEEKTNHDETKIYTDNVLKSSMMMDDFDVDAAEEVRDEDDEDIEIENEAETECFKLRDDLADLQAEISIKERLVSELEQSERRLAEKKLEELSLRINEMEIERDRVLAEIASKHSQKVVDAEQVRRIREDYEKKLTAMRDEFRKLQSVEREHRRMQAKQVAEQQQLLRLRNELNELKKTKVQLMQRIKEEARRAKAIELANMKKLAGLEKESRKKDNLIQKLQNKDRQREDFLKRSTDERSTYDRKNERNGTQRSVRSAPLRHGRGTVPLTKLEVNKAKTKWMAIEKNIRRRISQRQAITKMEDELEKIVAEKRILAEEIQRLEQQFIKANDLAERDLIGEHIDGCYAKMRYVQEQFTELRNTIAGIDNENIKVNLFYKSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2J4</accession>
    <name>A0A183H2J4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1704</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The WWE domain mediates non-covalent poly(ADP-ribose)-binding.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Ubiquitinated; autoubiquitinated.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01000856">
        <property type="protein sequence ID" value="VDO30507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2J4"/>
    <dbReference type="STRING" id="387005.A0A183H2J4"/>
    <dbReference type="WBParaSite" id="OFLC_0000170301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000170301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000170301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033509">
        <property type="entry name" value="RNF146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="7">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO30507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000170301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25839" checksum="BFAED35EAA7C4A9B" modified="2016-09-07" version="1">MERPNVDVDDSLSQQETESDECPICYQEFTYKTELPDCGHKFCFLCIKGVTLKHGACPLCRKRISCSIFLDPILTAPEDQPTTIRTATAVESVGIVAENIDDRKKNADKVQWFYGARHGGWWRYECRHENEIEKAYQNGLHSIDLLIAGSLFCIDFDSMCQYKKDLGRRGKFTRPVKRIEEGDSSLNGAIRGIAGLRTSTELNANMEQDMSEDLIAVAKNLSVLDFNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3J8</accession>
    <name>A0A183H3J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH LytTR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2058</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001109">
        <property type="protein sequence ID" value="VDO31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3J8"/>
    <dbReference type="STRING" id="387005.A0A183H3J8"/>
    <dbReference type="WBParaSite" id="OFLC_0000205701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000205701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000205701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000205701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13687" checksum="905118AA7BEF2168" modified="2016-09-07" version="1">MKLYGQFFHFPYMNEIVVNLGVYLENGRRFYFTSPNVQQIALNPAAKALMLSSHYVKMTHLRKHFYVRKCLLSNTTVYYIRNVSRKSFERCKEGELVDEQHIQTSYDMQIVHRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3P3</accession>
    <name>A0A183H3P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2102</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001143">
        <property type="protein sequence ID" value="VDO31881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3P3"/>
    <dbReference type="STRING" id="387005.A0A183H3P3"/>
    <dbReference type="WBParaSite" id="OFLC_0000210201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000210201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000210201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF258">
        <property type="entry name" value="CARBONIC ANHYDRASE-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552362" evidence="2">
        <location>
            <begin position="18"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000210201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="37044" checksum="2AD5A48BACDA1198" modified="2016-09-07" version="1">MTHIILFLATFYPQLSALRMNDYPWTYDNDLFGGPDFWGLLSKKWKMCSKGKMQSPINIKPASILFDPRLSDIKMDQVSTTAEMMNIGQMPRLRVLYDTHSSVINITGGPLNPYKYRLQRIDFHYSNDEMTGSEHAINSRNFPMEIQLIAYNTDLYTNFTTALTLPRGIAAVSIIVLIDEHTNEELLKITESIEKVPFRKRRITLHELKVWKLFPTLIDYVTYEGSMTSPGCYETVTWIILNHPIHITRTNVNFFYGDGLEEQKSRRVQNVRILLDDWRKLQRTTTEEKEPQYVAPNFRPLQHSYGRLIRTNIISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H487</accession>
    <name>A0A183H487_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1908 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2297</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001290">
        <property type="protein sequence ID" value="VDO32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H487"/>
    <dbReference type="STRING" id="387005.A0A183H487"/>
    <dbReference type="WBParaSite" id="OFLC_0000229601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000229601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000229601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000229601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24858" checksum="443885CCAED49F8A" modified="2016-09-07" version="1">MENRNGTACSNALPKQNISSTMKNETGEAHWYPPPSPLLISRIYGESSQFSSFPPGFAFSSGYIPYLSCYPPSSCAETIPLELGQFYCSPHGSFALGTENSPNKLMREFCRFTATINEDSCNTCCKIAARHHATSTDEVSGIIFAFDPNTPPMHTYIKSSQSIFREKRASKTSEINAAKPSIKMRNAVNLALSPGPPSGLISTDGSVTSSSNDIPQCFCCAPIKSVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4L3</accession>
    <name>A0A183H4L3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA methyltransferase 1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2423</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001392">
        <property type="protein sequence ID" value="VDO32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4L3"/>
    <dbReference type="STRING" id="387005.A0A183H4L3"/>
    <dbReference type="WBParaSite" id="OFLC_0000242201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000242201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000242201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="89"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="8">
        <location>
            <begin position="203"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000242201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51891" checksum="679586B4C4D104A7" modified="2016-09-07" version="1">MHKKSHRSDAYFKRPEGMHRELYNLLDRERNFAALMPTTTKNTGYCHQKARIGMRRVRPWEWTPFENAARTDGLKLNHWKRTDKLDDLYPFARFNKVINIPTFTDEEYDKCLNSAKWSKMDTHHLFDLCRRFDLRWVIIVDRWEGSTRRTMEEMKERFYNAINELHALRNENAEVLYYDAEHEKRRKEQLIKQWNRTEQQIEEEEMLIAELKKIEVRKRERERKAQDLQKLITAGERTPASPSTSIASVVPSSSMKKSHKSRLLKSSSVSNPSDHSNLRFPEFRSAGAHLRSQEMKLPTNIGQKKLKNIETVIEKLKLDLVPFGVADIVKGYNEFRARIVLLQELKHSLHSAEFELESLRTRYNALTGKTFDIEPRMRVRTTSESSITEMPQLGTEGAPMTNRTITDMIELTTSLPQTMRKRKAPSSSTSPSPVDNRRLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4N0</accession>
    <name>A0A183H4N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IL17_R_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2441</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001406">
        <property type="protein sequence ID" value="VDO32996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4N0"/>
    <dbReference type="STRING" id="387005.A0A183H4N0"/>
    <dbReference type="WBParaSite" id="OFLC_0000243901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000243901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000243901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBSPON-like C-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000243901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18172" checksum="C33C7E0BB25D5D5E" modified="2016-09-07" version="1">MKCPSLVEKMSCFNECPQQKRQHQSETTPVALILDYSYNKTRENFSHGNIHKKVVGKRSQLLYYCGIYELGWVNSNCIDKKISTKLYTGNNICVECQPEAQLHRNTATCTSDLSDGENGFWKLIGPKSCNGIWKRLYRIDNCRCETDFPRRDAFLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H510</accession>
    <name>A0A183H510_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2570</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001502">
        <property type="protein sequence ID" value="VDO33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H510"/>
    <dbReference type="STRING" id="387005.A0A183H510"/>
    <dbReference type="WBParaSite" id="OFLC_0000256901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000256901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000256901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000252">
        <property type="entry name" value="O-linked N-acetylglucosamine (GlcNAc) transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552390" evidence="2">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000256901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22637" checksum="5C98F741310801B9" modified="2016-09-07" version="1">MLMLQVISGSPLAVVAAVQKAQQQHVAATLTSTGAPVAVNIDIQVLTFFSVALTDMAHREYQAGDYANAEQHCVTIWRADPNNVSVLLLLSSIHFQLKDLDKSMQFSTMAIKANPKCAEAYSNLGNVYKERNQLAEALENYKIAVSLKPDFIDGYINLAAALVATGDLDQAVNAYVSALQYNPDLYCVRSDLGNLLKAMGRLEDAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H550</accession>
    <name>A0A183H550_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2610</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001533">
        <property type="protein sequence ID" value="VDO33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H550"/>
    <dbReference type="WBParaSite" id="OFLC_0000260901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000260901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000260901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000260901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8535" checksum="B32BABA831128E5F" modified="2016-09-07" version="1">MIADLTNLLCPEQQQQHSSEVNTSSLLLHHRLFPLLVEQITIGLAGTQQLYLSLTNHYNLLQGAFLAIFHSKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H571</accession>
    <name>A0A183H571_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRUD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2631</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001547">
        <property type="protein sequence ID" value="VDO33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H571"/>
    <dbReference type="STRING" id="387005.A0A183H571"/>
    <dbReference type="WBParaSite" id="OFLC_0000263001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000263001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000263001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF31">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="275"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000263001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50117" checksum="9CABA00A537F2474" modified="2016-09-07" version="1">MSYRCVVVSEMEEDFFITEYMSCGRNELKCTIKKLYSDFIVNEITPDGTILDIPLPCTTETIVENKEVKNSWTDINDISAPETITQELVSKIDGLLKDGINFVEIPTEDMGKQKRTLIHEWIRNRYNGLLESETVGRAIRVLVPCKQNRKRRTWPADRPDYVHFTLCKENKDTHYALSVISKFLGMKISSFGICGTKDRRALTTQRVSSYRCEIERLQQLNAKLRGIMLTDFTLNSEPCKLGNLWGNRFKIILRDVHPFSEADLIDRIEDFKSNGFINYFGTQRFGSCASNTAEIGIAILKKQWEVALKAILKPRKAHRGIQEALDEWNKSGNASGALKKLTDSQAYTTIEGQLLSSLSKNKCNYHAALLKLARNTRSLYVHAYQSLLWNKVVTRRVKNKVFRAIPGDLNVQGQEIKDFENEEVALPLISGSVKFPDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5C8</accession>
    <name>A0A183H5C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoporin p58/p45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001598">
        <property type="protein sequence ID" value="VDO33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5C8"/>
    <dbReference type="STRING" id="387005.A0A183H5C8"/>
    <dbReference type="WBParaSite" id="OFLC_0000268701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000268701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000268701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000268701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="57481" checksum="04A4896B0ED5F444" modified="2016-09-07" version="1">MSGFTFGTQGTTVSATPSTGSLFGTVSKPLFGSSTTTVQTTGAGLFGTPISSTVPSTTSTGEDYSAQRRLLVDYLEYPRKPRPLQESGLIGTAGTATTSTICGPFGSTSVTATPSLFGATPAATVAGSLFGKPTTGLFSSSAPITFTSGLSGASGTSTTTAGLGLGGTGTLATTGLISSNCLGIAGAGASGNPLEAEVQQVIMDLFNLLRDQIKKNHELSTEFAMNSSESCLHMDEKIEELVGTRVKNVDITRKAKGRADDVEKSFLTIHKILELLEKMQRDLRAAEQIRRRQKEISKNPHFGRKQAFSYLLTVCVEHENTVQEFWETLQLLQERIGAKLNKKDLTTKQDLQKHFEHYDQTFKVICSDVYRFKIQIEDLKDAFLEYQNRTVPYAPNPFERRKLKQTEKPTAEKRFTGADAFPSQITMMKIGEMAKLSTTQQTAGVSGFGTSNSLFGSKTFGTSAFSFNPSVTNTTAPLFKPFSATNSASAPLFGTLATSTAEPASVPTTTSSFTFGNTLNSSVSGTLFGGSASKPFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5R7</accession>
    <name>A0A183H5R7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2827</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001727">
        <property type="protein sequence ID" value="VDO34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5R7"/>
    <dbReference type="STRING" id="387005.A0A183H5R7"/>
    <dbReference type="WBParaSite" id="OFLC_0000282601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000282601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000282601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000282601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25639" checksum="5D7D53550E127B83" modified="2016-09-07" version="1">MELINAYDLYKLEQVDELLETGLQSLDALFGGGISPSTFLEIVGLSATGKSQFCMQLAVNMQKNEKKKDSVYVDTEGGFHTKRVCDIAKNLLKAVEPLESLKHIRVSRCRDLVELTSAIHRLELLVQQNPGIGLVIVDSVAMPLRGENDSALRSRLEISRILSKLAASYRLIVNFQMSHRPSTRLWLCPPDTNSRNSWIFLTKSPSAKNGSIPFKITEGGLVEIEHDIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6S6</accession>
    <name>A0A183H6S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA_lid_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3188</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002057">
        <property type="protein sequence ID" value="VDO35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6S6"/>
    <dbReference type="WBParaSite" id="OFLC_0000318701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000318701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000318701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="2">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000318701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11005" checksum="17525BD9DC8E40F2" modified="2016-09-07" version="1">MCRGMNLENVDFEVIARATDGWTGADLKGLVTNAQLIAHKRINGRFGDKDVDLNENMKYVLSQEDLLFAIKESQPSKNRSCSKSDRKPCISPGLFTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H778</accession>
    <name>A0A183H778_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3340</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002203">
        <property type="protein sequence ID" value="VDO36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H778"/>
    <dbReference type="WBParaSite" id="OFLC_0000333901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000333901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000333901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000333901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10091" checksum="70141D050F792281" modified="2016-09-07" version="1">MRTLGVLCQRRRSETSKLRKCSTAREKTREGFSKTQTREEEASTLEGVKSITRDEAPSVINQRKTLPKKRDGSLTNDRLEVEIEVILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H784</accession>
    <name>A0A183H784_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Splicing factor 3B subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3346</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002210">
        <property type="protein sequence ID" value="VDO36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H784"/>
    <dbReference type="STRING" id="387005.A0A183H784"/>
    <dbReference type="WBParaSite" id="OFLC_0000334501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000334501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000334501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000106">
        <property type="entry name" value="Splicing factor 3b, subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000334501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17776" checksum="961A99DDF88F8381" modified="2016-09-07" version="1">MSQILRRKMNLVQIMALANRGRNQKLPPEVNRILYVKNLPYKITSDEMYDIFGKFGAVRQIRVGNTAETRGTAFVVYEDIFDAKNACEHLSGFNVSNRYLVVLYYQATKAYRRMDTDKAKERLEEIKERYNLGGDLEKEKKDKLGYTPTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7P7</accession>
    <name>A0A183H7P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal acetyltransferase B complex subunit MDM20 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002358">
        <property type="protein sequence ID" value="VDO36766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7P7"/>
    <dbReference type="STRING" id="387005.A0A183H7P7"/>
    <dbReference type="WBParaSite" id="OFLC_0000350801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000350801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000350801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000350801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30274" checksum="0BD85D775091C7CF" modified="2016-09-07" version="1">MIAKMGKKVDNEKIENKIRSQNYNLKSSATGFDGPMFRGDLSMGELIKPRRRLLGLAKSSVTSGILEWRIRQQNAIDAGSNKKAMQEAEKVLKKHPTTHCAKVLKALALIRADRVSEAWPLINEVESVKDDFDENTLQALCHCFKEAYTPERICTLYEKICARYPKNEQYLTHLFMSYVRVRNYKQQQKTALALYKEFQRNPYYFWNVMSIVMQAITGDQKLAQSTLYPLAEKMVTKMIESNLIQAEAGLYYSVFDLRACFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7P8</accession>
    <name>A0A183H7P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMC_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3510</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002360">
        <property type="protein sequence ID" value="VDO36771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7P8"/>
    <dbReference type="STRING" id="387005.A0A183H7P8"/>
    <dbReference type="WBParaSite" id="OFLC_0000350901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000350901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000350901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO36771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000350901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37031" checksum="9267C0F1BA6E2A12" modified="2016-09-07" version="1">MRERDAYMRSVVETMNALKKSLKESDLKKEQLQKDIQDMKKNIEDCTRRATRLEKQHSWIMEEKHHFGQTGTAYDFTDYSIEKGQKELEDRTARKHALERSINAKAMNMLGTAEEQCRQLEIKMEQLMNDKAKLLDAIKKLDIKKKNEIIKAHEKVNRDFGNIFSTLLPGTNAKLEPPAGATSALGGLEVKVAFRNKWKDSLGELSGGQRSLVALSLVLAMLKFKPAPIYILDEVDAALDLSHTQNIGSMIKTHFKESQFIIVSLKDGMFNHANVLFKTRFVDGTSAVVRTENKDQWVIDEPIQIRDIEKENDSDIPRKRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H812</accession>
    <name>A0A183H812_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002491">
        <property type="protein sequence ID" value="VDO37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H812"/>
    <dbReference type="STRING" id="387005.A0A183H812"/>
    <dbReference type="WBParaSite" id="OFLC_0000362301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000362301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000362301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000362301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29222" checksum="E1917AC1EED29D7B" modified="2016-09-07" version="1">MKTSYIVRTADQIADLHNRLLDSFPSEAGAQTGNPRVLPYLNRSQPSSILGYIRALPDLPARVLVCPIVRDFFYPSRLESCSLSSTPQSLISRSLPSLIDLKKPPTSSNTPSPSNPLLPETSACHPLSVTFLPVTTVCSAGMMGCTSVACPPFSMTNVPPPPRGPLLSLARPLSLLATTANVPVYPSLLSLPPNPNGLSCCNCAGRHPFAYCTQPTMLQIIASGEYKIDYNNMTTNMSSTILPSEMTGSVASINNSALPLSKNFSTPPPAPNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H856</accession>
    <name>A0A183H856_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chalcone-flavonone isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002536">
        <property type="protein sequence ID" value="VDO37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H856"/>
    <dbReference type="STRING" id="387005.A0A183H856"/>
    <dbReference type="WBParaSite" id="OFLC_0000366701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000366701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000366701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000366701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26026" checksum="EBD4ABFFC04189D1" modified="2016-09-07" version="1">MEASDLMEIGHVTFDQALKRKMTKARSKFTTGPFFQLVSYQFGQFKLLVRFEVDCADYAAVKMQSDNQLEKEDESEPKKEKFSENNVISFMEYGEVPRNIPLQLLTTYPQGAGFPFFTWAQMFFTAADQEIVGWFKGNGDFGKPAMNALSDISKLIKPLPYVVLSKVHDCLDKIAKFLIKNDPEFKCALIWKGKNHLEIFAKTSTTGAVSPGVKELMKTQCKELDESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9R7</accession>
    <name>A0A183H9R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHR-BD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4230</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003127">
        <property type="protein sequence ID" value="VDO39342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9R7"/>
    <dbReference type="STRING" id="387005.A0A183H9R7"/>
    <dbReference type="WBParaSite" id="OFLC_0000422801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000422801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000422801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000422801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29022" checksum="695B6DD97EBE4BAB" modified="2016-09-07" version="1">MQEPFSEPALLPLDAKNFLSKKKARLSLFGNYWTNEFPLDAVGNAGRIGCKDENNSEQSISLQISMCQSGLTKVITFLPFYLLHNESRFPLEIREFGVQNWVLVTSQTCIGFWPSQKENRKYAVVRYGGTTEESILFPITESFEGFCQINNDYLGVYVIVTVCESSSIIKLESFEPGMAPAIIMNATKKSVEFGQKGARSKKTLGPWESCAFTWTDVIRNRTLEWKSGDAIHSDDLIRNAFEDYKTSRSESNPFTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA28</accession>
    <name>A0A183HA28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4338</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003249">
        <property type="protein sequence ID" value="VDO39683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA28"/>
    <dbReference type="STRING" id="387005.A0A183HA28"/>
    <dbReference type="WBParaSite" id="OFLC_0000433901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000433901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000433901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000433901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20678" checksum="36DEA27C6B25BC55" modified="2016-09-07" version="1">MLTFGRENGKLKEQEIYGCAGVHVSMYRSLQSLGRIEPVPREGHIAEDSSSLAAPATWMNDTGISVCSANVPTIGNQNNAALNNMLKRPSELLLDTVEYEKRIKLESNHQEDHKNGLIGIAAKTDISAILSGSSPHSGTTGAAHVNTIVTKVDISTAADNVERTAWNGQLSCTTDKRDPASSTCVERLGSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA55</accession>
    <name>A0A183HA55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS4365</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003280">
        <property type="protein sequence ID" value="VDO39760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA55"/>
    <dbReference type="STRING" id="387005.A0A183HA55"/>
    <dbReference type="WBParaSite" id="OFLC_0000436601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000436601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000436601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF73">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="44"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO39760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000436601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51793" checksum="83E106118664E8FD" modified="2016-09-07" version="1">MKCLNEQEMRFQKIIEVLENDYTVENYTTIMQRIGSFNETMQIKVHTNEEILNELKNLHRKYPHITYLYEIGKSIKGIPLIVLAIGKFPMKHTAGIPEFKYVANIHGNEISGRELLLCLADILLVNYGKNEVLTRLVNRTRIHLLPTMNPDGFTEAKSDSYSWVQGRTNAAAVDLNRDFPQRLNPTAIQNVQPETSAIMRWTKSIPFVLSANLHDGTLVVNFPYDDAKMEGIEAKTGDHELFVMLSYFYARAHKYMWKKGPRCINQPGDDDLNEGITNGNKWYRVTGGMQDWNYVFANCFELTIEMSCVKYSTGEQLKQIWNDHKFALISFIEKVHNTISGFVLDEITGAGISNVQISIDNVGKIVLSSINGDFWRLVIPGTYNVSFQHFLYETVIKHVIVTKKKPYEFLNVTMLRKRYTRNFAQIPLINSQGNSASSIFIILIFFVFSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAH0</accession>
    <name>A0A183HAH0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4485</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01003421">
        <property type="protein sequence ID" value="VDO40131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAH0"/>
    <dbReference type="STRING" id="387005.A0A183HAH0"/>
    <dbReference type="WBParaSite" id="OFLC_0000448101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000448101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000448101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000448101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43573" checksum="1917B102AAE09199" modified="2016-09-07" version="1">MALEFKILSKVRSARHGRLRLSHADVDTPVFMPVGTQGTMKGLLPEQLSGMGFRLMLCNTYHMGHRPGHRIVRKAGGLHSFINWPHSILTDSGGFQMVSLNDLMNVDEKGVNFESPHTGEKMILSPETSIHIQEDLGADIVMQLDHVIHVLCDGPIVEEAMERSIRWLKRCRDAHTRKDQALFPIIQGGLNISSRKKCTAAMLQHTETGIAIGGLSGGEDKNSFWRIVACCCENLPEHLPRYVMGIGWPIDLVICSLLGADMFDCVYPTRTARFGTAIVRHGGMLHLSRNEFENDFRPIDDSCPCPSCRNYTRAYIHSILNQETVACHIISVHNLQHHMDLMERLRTAIDTNTVQTFLKEFLTEQFPDGNIPKWVCDAIQHMHYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB30</accession>
    <name>A0A183HB30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4692</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003686">
        <property type="protein sequence ID" value="VDO40750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB30"/>
    <dbReference type="WBParaSite" id="OFLC_0000469101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000469101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000469101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000469101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18557" checksum="9AA97CFE93F01A6A" modified="2016-09-07" version="1">MSSSVDEDHSFWKTKERLFLFSDQIISNVFICCWMYVVINRGRIKKKEIGAFFDKYCSLFMKRFEQQNIGIVTVGELFAIAIKYGFKETSFRHFKEIAARWMCRRLEVIMRNKGLYGLPHNLNLVNIFVEIDDLECSLDYSKWLEEFMTPFFRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBC0</accession>
    <name>A0A183HBC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4783</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003807">
        <property type="protein sequence ID" value="VDO41020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBC0"/>
    <dbReference type="STRING" id="387005.A0A183HBC0"/>
    <dbReference type="WBParaSite" id="OFLC_0000478101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000478101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000478101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000478101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22783" checksum="FFA2B7DD838A70A1" modified="2016-09-07" version="1">MARICSFSSFSTERHAVEHMTSGSLFVPLIRLKISLSSLSLSRLSLVSVQTLAQQLYSRISDSIASLGYFQFSNKRRRYDRDEKTIDVPLRVFCDQNIRTRIVGRGSLRKSVWPVSWLEAIFLPEFPNNSNITEKDFLILNCIGEGTFSKVYRVCLKLNRNFLFAMKKQLKSEILTKNAIQQVKNEASIHVGSFYPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBT1</accession>
    <name>A0A183HBT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4942</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004009">
        <property type="protein sequence ID" value="VDO41527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000494201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000494201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000494201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000494201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23700" checksum="F472F35162E8A6D8" modified="2016-09-07" version="1">MTAISMFLVSMDRIISVVKPIMYYKNMSNIQHYLIIGGNLSILLLISSSVICSYLNNIRVNAFCWLVLQNFLETPNSRCPIFNRLFYGVRISAAAGSVTLYIITLFIVRRYTKRIKEEQNYGSIKISKRQLNFTKTVGLSCFVTASLYILPMIVAFFETSNEMIPNSVYSTIIIISCLNSFSKAIIFGCRTYEIREAVIDLMPGVFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCW6</accession>
    <name>A0A183HCW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5327</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004521">
        <property type="protein sequence ID" value="VDO42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCW6"/>
    <dbReference type="WBParaSite" id="OFLC_0000532701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000532701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000532701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000532701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10155" checksum="13AC9B9BF6445CE0" modified="2016-09-07" version="1">MVNKWQVQALPAPSLNGTAFVHPFLSLLLFHNNTMTGSTDPATDRSIDRCLFHNSTHRIQIDQCERPTSSNRAVVSIIYNRTNRDIICW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCX6</accession>
    <name>A0A183HCX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5338</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004533">
        <property type="protein sequence ID" value="VDO42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCX6"/>
    <dbReference type="STRING" id="387005.A0A183HCX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000533701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000533701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000533701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000533701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21826" checksum="E5446F3B327E8BB7" modified="2016-09-07" version="1">MILIKIIRKCHLSSVPESSSSEFLSGNILKSIELVKSRSPTKSFIKQKPVGPFVGKVLIEANDNLLSETYYHGIVSRVDMEKMLIRDGDFLLGIPEEDEQEFQNNNEPNELQSILWIVRYSNDLWAFNIGLTEKNLCFVNQKCFKKITEMVSHYVRTRKSIHEVLPIVVKRPIPHPVSCFYPFTRNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD10</accession>
    <name>A0A183HD10_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5372</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004578">
        <property type="protein sequence ID" value="VDO42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD10"/>
    <dbReference type="STRING" id="387005.A0A183HD10"/>
    <dbReference type="WBParaSite" id="OFLC_0000537101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000537101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000537101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000537101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14723" checksum="FC8962191B74B2A3" modified="2016-09-07" version="1">MWGEMHNSEVGCSSDTEELYDALKTAQNRKQRQAGGWQTIGLDHMLFKGIQKKGFRQPTPIQRKAIPLIIDGKDVVAMSRTGSGKTAAFVIPILQRLKHRDMKGIRALIIEPTRELAMQTFSVVKEVVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD91</accession>
    <name>A0A183HD91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004695">
        <property type="protein sequence ID" value="VDO43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD91"/>
    <dbReference type="WBParaSite" id="OFLC_0000545201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000545201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000545201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000545201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4141" checksum="C3FD665B0BA45EEE" modified="2016-09-07" version="1">MRSIPTPMKRSRIPRAAVPGNSNSTLRKSHTVITYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDB6</accession>
    <name>A0A183HDB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5478</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004725">
        <property type="protein sequence ID" value="VDO43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDB6"/>
    <dbReference type="STRING" id="387005.A0A183HDB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000547701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000547701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000547701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000547701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26691" checksum="FB29881F5C59548D" modified="2016-09-07" version="1">MNVDKKQVDGDGFVVPQLPIQLSKPKTVSDQDVSLEGTSKEASINQRHTVFVSNLDFKLSTERLEHIFPNAKEVRLVYRGMSKLHKGFGYVDFLTESEAREALKMDRTQIDGRPMYVSEYKPHEKGRSAEFRYNTGLERNKIFVNNIHYDATEEQLKEIFAAFGAIRDIRIVTHKSGKSKGCAYIEYENDGDAANAVKAGEDLILLERKLSVAISNPPKRKEQMQRLSFNTTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDF5</accession>
    <name>A0A183HDF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TMV resistance protein N-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5517</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004787">
        <property type="protein sequence ID" value="VDO43437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDF5"/>
    <dbReference type="STRING" id="387005.A0A183HDF5"/>
    <dbReference type="WBParaSite" id="OFLC_0000551601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000551601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000551601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000551601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16625" checksum="A2192F634FE4187D" modified="2016-09-07" version="1">MIESTRISGDKIDIITKMPGHIENEDDTLPPEIMAADPFATTLAELTVSTLSSSRENIPLNPLVTSSFLNNSDVMLSEEANVDQTSALDEILDTDATEKTFSTIASSLKSEQETIITRTTNRIQEMLQEAKVTVSEEQDTTVASESMLLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDG5</accession>
    <name>A0A183HDG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-C3Hc3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5527</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004798">
        <property type="protein sequence ID" value="VDO43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDG5"/>
    <dbReference type="STRING" id="387005.A0A183HDG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000552601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000552601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000552601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="4">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000552601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="38928" checksum="FB6739A64B3F342C" modified="2016-09-07" version="1">MKLDLKIDQKTLAAATNFSKVVEEAVSTHLSSSVMPVENDEVDSSLIPNIPPTSTSTAQSFHSISPFTVMEPANSTKESPICDSSVESSTALLGRNELCEQVNEVCSSTVDASPFCDTACSPIQLELQTKLPHGIMNNYIKSPDDTPPASSDEQNRIASQSSNKEELTGLVTAPTGPDNIYLTPCASTSSAEVDAATFSPLVAKRRKEKSTTASHLCEQIDPEKGQCRQRAIVNYRYCIRHILLDPEAPYIQCQHQRKPKSKRDTNLLCTNAIRKDKGTIYCSTHLIMNGLMEPRKKKAKTGAVIVESTELSSSCSNNVWNRSGISGKSNLSSTLSPALMDTYEEINCMCYFVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDX9</accession>
    <name>A0A183HDX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005027">
        <property type="protein sequence ID" value="VDO43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000569001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000569001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000569001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000569001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10816" checksum="35823D2BFD8EF42D" modified="2016-09-07" version="1">MKSVIHLFFIYGERGRRTNVGMINRKTYEMPSIGFVFLNGLFNLRECNSECDRHLQRSTNQSYNCAVKSMGKIYEKRQFKTQSEIKSQVDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE10</accession>
    <name>A0A183HE10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfite oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5722</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005070">
        <property type="protein sequence ID" value="VDO44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE10"/>
    <dbReference type="STRING" id="387005.A0A183HE10"/>
    <dbReference type="WBParaSite" id="OFLC_0000572101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000572101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000572101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="2">
        <location>
            <begin position="117"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000572101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25373" checksum="D56800017FABD625" modified="2016-09-07" version="1">MKAGIDPNDKRIKHVILRGADMDTEGNNYETSITFEKAMQDEVIIAYKMNDEEIPRDHGYPMRLIAPGIVGARQVKFLSAIILSEEESTSHWQKRDYRGLPPYIGPTDYQDFEMVPSIQEYPVQSAFCSPAASTKISRSKGEFDVMGYAWSGGGRGIIRVEVSIDGGETWQAAELVQDPDQDIVCLNSWNLNLNLNLYLSSDRLQRKSERKLYNKLFCKIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEU3</accession>
    <name>A0A183HEU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MMS22L_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005474">
        <property type="protein sequence ID" value="VDO45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEU3"/>
    <dbReference type="STRING" id="387005.A0A183HEU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000600401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000600401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000600401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000600401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="19036" checksum="D2B8F62542490AAE" modified="2016-09-07" version="1">MVDTVVLVLFKQWANLKPVIKKEFFDYFFGNALLKYRGSMEIRSELLKACAKLVKRSVFDGHACDIDLLASRLYALLTDQEPEFHEVVFEFFTKILAEFDSYWRLSEFGLSYDFQYKAKISFENNGLLKIYSKCLHIVSRFCIFIGNLEFPSNTELFIHHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEW0</accession>
    <name>A0A183HEW0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6023</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01005492">
        <property type="protein sequence ID" value="VDO45125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEW0"/>
    <dbReference type="STRING" id="387005.A0A183HEW0"/>
    <dbReference type="WBParaSite" id="OFLC_0000602101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000602101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000602101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF65">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO45125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000602101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16452" checksum="CF92FA11A9927833" modified="2016-09-07" version="1">MLNEKLIIKIICAVGLFFIAQVGVFWTQLQNLDEKKFMLVAEIDTLIRKRDELNKKIWMQEKEAYRMEEKLQRIDNLVRDRILLAEVRKDLPFIYFITPTYRRPTQKADLIRLAQTLAHVPNLYWIVVEDANDTSPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG79</accession>
    <name>A0A183HG79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6491</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006192">
        <property type="protein sequence ID" value="VDO46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG79"/>
    <dbReference type="WBParaSite" id="OFLC_0000649001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000649001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000649001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000649001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14122" checksum="916B75E3C125AA81" modified="2016-09-07" version="1">MRIPFDAECMNVDPKTVKELFSTLKELNRLTKLDDPNSVLECSNFSDLNKQHMLRLWHAKKDEDLKWGIDVVVANSNIRKSLYPKIWLVIDGQEMEMNLEVFAKLRFEVSRALNRIDHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGY9</accession>
    <name>A0A183HGY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6751</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006607">
        <property type="protein sequence ID" value="VDO47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGY9"/>
    <dbReference type="WBParaSite" id="OFLC_0000675001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000675001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000675001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000675001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8955" checksum="A36D00A240923D6B" modified="2016-09-07" version="1">MQAHILTSTSKNRSILLDVQAEAKKKSVAIHVSHGLGNRGKKAPRSSSVNELETNYINVDIGEQNLAFYYTENKKCEYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHB3</accession>
    <name>A0A183HHB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH LytTR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6876</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006809">
        <property type="protein sequence ID" value="VDO48221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHB3"/>
    <dbReference type="STRING" id="387005.A0A183HHB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000687401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000687401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000687401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000687401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24416" checksum="478573195830E109" modified="2016-09-07" version="1">MKDYSQRLFDSVKIAENVLKTSLSALLPLNYLEIGKDNIPFMYNESSSKKLIIMDQPSFMITTIKNFSVVINLNTNTKIDNRRKLIDRTIVIYNPEPYERMETIELLVSDPDIIVIGTDGPIKAQIEPYFDTISGNFTKNYLLVFFTFLKALSFTHCTIQKTHSATTEIAQILSPIKSAKTIKYFHVRTINKDKFVLQTSRILVKLNPENGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI72</accession>
    <name>A0A183HI72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase_M1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7184</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007325">
        <property type="protein sequence ID" value="VDO49721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI72"/>
    <dbReference type="STRING" id="387005.A0A183HI72"/>
    <dbReference type="WBParaSite" id="OFLC_0000718301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000718301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000718301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO49721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000718301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30765" checksum="E33901EEF6217D9C" modified="2016-09-07" version="1">MRKETKVRYRETNSPLQIQILLTLTIFFLFIILLLTFLIFSSKQRFDLQTTLQQRYSASNTSTITSQSYFRLPNTIHPLHYDLKLQIFLPYRKELNFNEKNFSIHANVAIRIICLHATNQIILNAKRLKFDKNDIEIQDNRNKSIQLISVNRYQHETDDIHTVEIILMQQLNSGYDYMIYIRYQGVINDVWSGGLYKTQYNINDETRLLALTQLQPTDASRLLPCFDEPEMKATFRIVLIHPMGTSAVSNSPVRRYRHLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ24</accession>
    <name>A0A183HJ24_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7485</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007851">
        <property type="protein sequence ID" value="VDO51197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ24"/>
    <dbReference type="STRING" id="387005.A0A183HJ24"/>
    <dbReference type="WBParaSite" id="OFLC_0000748501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000748501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000748501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF28">
        <property type="entry name" value="BESTROPHIN HOMOLOG 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO51197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000748501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="38372" checksum="EC65FBED2EF6B18C" modified="2016-09-07" version="1">FFFFFKLKIYVKAFRWWRQFECIPWPEDLLSLLCTFMPGKDGRSQQRRHTIARYVNLMAALVYREISSSIRRRFPSMKDLVESGLLTDTEFKLLSEISKDIKNVRWMAPLHWVQQIVMDEVNDNPQAHLALVNHFMQELKAYRASLRKLFSYDWVCVPLVYTQVAALATYAYFGFCLIGRQYLDPSKKYRDYDVDFVIPIFTIVQFLFFVGWFKVGQDLMRPFGMDDDDFELDYIFERSVCLSFAIVDRLQMNDYEPLQKDKFWTADNSEAISIPRTGLAHKHKPRMPIRHVPSYKPIERNDVEEGKTRCHMWKKKWHGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKI4</accession>
    <name>A0A183HKI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7996</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008720">
        <property type="protein sequence ID" value="VDO53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKI4"/>
    <dbReference type="WBParaSite" id="OFLC_0000799501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000799501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000799501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000799501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="3874" checksum="1491D51D16E83CC2" modified="2016-09-07" version="1">MGGQTPLKLAKTLNERGFNISGTSFDFIDLAEDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL29</accession>
    <name>A0A183HL29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRY_EERY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8193</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009069">
        <property type="protein sequence ID" value="VDO54479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL29"/>
    <dbReference type="STRING" id="387005.A0A183HL29"/>
    <dbReference type="WBParaSite" id="OFLC_0000819001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000819001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000819001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000819001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9092" checksum="44019E85EE6881B2" modified="2016-09-07" version="1">MDFIPEAKLDDTDKRSVVDVEELQCEYERYRILVLNEFDRVSEKTFLKEIAAKEFWPDESTSTSFARAEQEKKRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLE3</accession>
    <name>A0A183HLE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8306</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009278">
        <property type="protein sequence ID" value="VDO55042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLE3"/>
    <dbReference type="STRING" id="387005.A0A183HLE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000830401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000830401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000830401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000830401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9019" checksum="ECEEE9F93E35E139" modified="2016-09-07" version="1">MDSEPENSKILEVAGGDQWSKNKNAVKSKGTMINSLDDLKTIFHNLLHPKNNKIVDQAFEQIEQKTHLGREKVIFDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLL1</accession>
    <name>A0A183HLL1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8372</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009409">
        <property type="protein sequence ID" value="VDO55347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLL1"/>
    <dbReference type="STRING" id="387005.A0A183HLL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000837201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000837201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000837201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO55347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000837201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11996" checksum="D801A9B05AE1A898" modified="2016-09-07" version="1">MYGVWFNNHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDSELGRCVYEPTEMAQEFRKFDLKTPWDSMPNFRDESMMSRYEQISLEGPKEEIEKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLP4</accession>
    <name>A0A183HLP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8404</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009468">
        <property type="protein sequence ID" value="VDO55514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000840501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000840501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000840501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552565" evidence="2">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO55514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000840501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12013" checksum="1DA6834188B353A1" modified="2016-09-07" version="1">QSNFSNKFSLAIKVAATSQLLLLTTAATPPSQDRSSFGLETNDLRSFSPTDFSTNFSQQTPITTNDISRGKGSTFPGTLPLEQQEPQLVTFQNVQQNSEGQSFKIEHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLQ1</accession>
    <name>A0A183HLQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009491">
        <property type="protein sequence ID" value="VDO55567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000841201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000841201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000841201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000841201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10346" checksum="8DB09A47465BB191" modified="2016-09-07" version="1">MCKLMRNYKESGRTTVNISNRNISKINSDRRLSTGTLNRLILVAQALESEVESRRQIDVNGKRIVIVLRTINLVRKKKLIINLNSKYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMR4</accession>
    <name>A0A183HMR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ChSh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8776</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010205">
        <property type="protein sequence ID" value="VDO57346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000877501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000877501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000877501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000877501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20326" checksum="30997FC367EDAD74" modified="2016-09-07" version="1">SKTSATEETQRETRSRSARNAAFGKKTPKSEQIKDEQEEEEEEEEEEGKEMKSQRTTRSSERRSVYSKYLKKDKDRRDEKSANSSLSERGKGREMESEKTNSEEAESSKQETIHKMETSPKKFARKQLSENDVIVMDDETFSAVVKDMSMRSPSEYGEYPFPQNTYFRFYFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN02</accession>
    <name>A0A183HN02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010377">
        <property type="protein sequence ID" value="VDO57780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN02"/>
    <dbReference type="WBParaSite" id="OFLC_0000886301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000886301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000886301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000886301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="4851" checksum="3D89910EECF955A8" modified="2016-09-07" version="1">MTTLSSTFSRRCCIIKEHVEKGMIRCGVPNPSDDATVDLSKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPJ0</accession>
    <name>A0A183HPJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9402</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011475">
        <property type="protein sequence ID" value="VDO60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPJ0"/>
    <dbReference type="STRING" id="387005.A0A183HPJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000940101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000940101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000940101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552600" evidence="6">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000940101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19002" checksum="B93B44CC25A46A5B" modified="2016-09-07" version="1">MIPCLLLTIFMTLLVRMLIEARERRIRLCRGQTGVKSQAERTTTMLTAIVAVFLVTELPQGILVFAIGLKPGIRYAMQYLGDFIDVLSLINSSFNFILCALMISSNVLISRREFLLTFGSCCPKLSENISGTGSRTLMMTSRIPQSQRRELLAVVKCPDEMNENNNTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPZ9</accession>
    <name>A0A183HPZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9563</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011857">
        <property type="protein sequence ID" value="VDO61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPZ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000956001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000956001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000956001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF102">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO61489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000956001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="5814" checksum="8AE61EDE5F161FB1" modified="2016-09-07" version="1">MVIHSWLRSAGECSVAQRLGFVLEEAGPSVTISTFTNVITFGIGALTPTPGEHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQU6</accession>
    <name>A0A183HQU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rad4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9858</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012552">
        <property type="protein sequence ID" value="VDO63960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQU6"/>
    <dbReference type="STRING" id="387005.A0A183HQU6"/>
    <dbReference type="WBParaSite" id="OFLC_0000985701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000985701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000985701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4/PNGase transglutaminase-like fold" evidence="1">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000985701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17075" checksum="99BBB735FB05CDBA" modified="2016-09-07" version="1">MNMLRSEHTEIFVKKNIDNNDNSAVWEKKLYEVTKKIKIKADDCSEYSDVKKCQVKKKANIKKSKENVESMDPWYGSVDMPEGLEANATVPMHYVVCIDNNMGMRDVTARYASKFLSAEMRRLRVDSSWWTDTLKFSCDLSEQESKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRT7</accession>
    <name>A0A183HRT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013337">
        <property type="protein sequence ID" value="VDO66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRT7"/>
    <dbReference type="WBParaSite" id="OFLC_0001019801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001019801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001019801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001019801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16511" checksum="2F5D6F23434555D5" modified="2016-09-07" version="1">MFNCPMTQPPTSINLPLGNLTIPVHMSPSYIPSTIIAQPVTSTVTSTSIIPPPPPYHTVNLNTIPCDTDIDVVGITDVARDVHLDDDNEQYDKPLDLSLKKREVRCLPSCSVVHKSQPRPTVIRNGYGIFFRKYSFLFSFSFFFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSE3</accession>
    <name>A0A183HSE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013839">
        <property type="protein sequence ID" value="VDO68244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSE3"/>
    <dbReference type="WBParaSite" id="OFLC_0001040401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001040401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001040401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001040401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5596" checksum="918C7845586A868D" modified="2016-09-07" version="1">MWLRMPSHADYHLFLPTTAVVSLAHGTDCGGGGGKIQVGVTLYWLRQAALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSG1</accession>
    <name>A0A183HSG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Skp1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013882">
        <property type="protein sequence ID" value="VDO68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSG1"/>
    <dbReference type="STRING" id="387005.A0A183HSG1"/>
    <dbReference type="WBParaSite" id="OFLC_0001042201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001042201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001042201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001042201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9943" checksum="0219E3B90AADA270" modified="2016-09-07" version="1">MIKGKSPEEIRRTFNIKNDFTPEEEEQSLLCPFLCDFLLHLFERKMHGAKIESAGSGGLKKFCALMKPWRSIIGCKNRFQSYSINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSJ8</accession>
    <name>A0A183HSJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10455</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013946">
        <property type="protein sequence ID" value="VDO68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001045901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001045901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001045901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001045901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11525" checksum="BEFFDC3503EE4FDE" modified="2016-09-07" version="1">MHELLEQYLNVTCQRERINVQLTFNRRKHPEMTKSIREMIWRGRMCIGDDKSGSCCSQLNMIQDYHIVLVGYSKCGIEKTFFAGGFNFIAKVGLFLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTL4</accession>
    <name>A0A183HTL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS10823</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014885">
        <property type="protein sequence ID" value="VDO71628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTL4"/>
    <dbReference type="STRING" id="387005.A0A183HTL4"/>
    <dbReference type="WBParaSite" id="OFLC_0001082601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001082601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001082601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF113">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO71628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001082601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20307" checksum="524DCDF63C434649" modified="2016-09-07" version="1">MKAAQLNRIDVSVEKYVDRIWDLARSEKYQKLSKSKLKDAFRRDSKEHFYQYVDTVFAAHRKYRHGYDKDAPSWDFITSFFFTATMLTSIGYGYVAPSTFSGRLFGVIYCLIGIPLTLVTVANIAKFVSECAFMIHYKCWKKFAQWKDRRKAFRHHHAAIFDDDENEQVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTS9</accession>
    <name>A0A183HTS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS10889</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015049">
        <property type="protein sequence ID" value="VDO72161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTS9"/>
    <dbReference type="STRING" id="387005.A0A183HTS9"/>
    <dbReference type="WBParaSite" id="OFLC_0001089101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001089101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001089101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF139">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO72161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001089101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16538" checksum="1D6362768E832A1D" modified="2016-09-07" version="1">MVAEAGANRSPCSNIYPGSSAFSEVETAGIRDFITYQILDLKIYISLHSYGQLFLAPWGYTNDKPNNYYDQKEAASLAVEAIRNRTGAKYNYGTISELMYPASGTSIDYMQDKGIPYIYGIELRPEDAENNFGFTIPARFIEPTGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU49</accession>
    <name>A0A183HU49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015350">
        <property type="protein sequence ID" value="VDO73092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU49"/>
    <dbReference type="STRING" id="387005.A0A183HU49"/>
    <dbReference type="WBParaSite" id="OFLC_0001101101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001101101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001101101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001101101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21722" checksum="7698926F33980DCC" modified="2016-09-07" version="1">MFRIHMDSGTCDVFNLDEVSGDEFENKVFLENIVLGCGKHQLYMYERSVVMGPIPFWKITLLEDSMTFVIISETICADQNEEKCSRFPIVLDGDKRRVFKLQDNHDIVVYDGESNCWNTYPPSLDTPTDASFLLNLLRVRGISETYGRTVHRMGAVESPLTFYVNEGICIAKIFRHAYHAFYHIIFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU97</accession>
    <name>A0A183HU97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015482">
        <property type="protein sequence ID" value="VDO73479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU97"/>
    <dbReference type="STRING" id="387005.A0A183HU97"/>
    <dbReference type="WBParaSite" id="OFLC_0001105901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001105901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001105901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001105901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12081" checksum="14D0EE214F9B33D1" modified="2016-09-07" version="1">MIIGKAPRTNAGVTSIDDTRNVAAAAAAAPLIPTLDPYNTMSSITGPATVRPDLVSGVGVPVSRDQFDYNGILGGPGGMNGMTSATSTSSLGTIGMATPRVSTKKRSKSVKLDSDDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVP7</accession>
    <name>A0A183HVP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11557</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016814">
        <property type="protein sequence ID" value="VDO77338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVP7"/>
    <dbReference type="WBParaSite" id="OFLC_0001155901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001155901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001155901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001155901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9528" checksum="02F1589067624486" modified="2016-09-07" version="1">MKRKITYHKDGRRFVGDKIENEQSASNLWSTALTRSVVRDLKDQSNEDPTSRNTGLKRYGEFFGQNKAGKKKWHMINREIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWD0</accession>
    <name>A0A183HWD0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="3">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS11790</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01017518">
        <property type="protein sequence ID" value="VDO79266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWD0"/>
    <dbReference type="STRING" id="387005.A0A183HWD0"/>
    <dbReference type="WBParaSite" id="OFLC_0001179201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001179201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001179201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="10">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO79266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001179201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20171" checksum="6EA01F172136AAC9" modified="2016-09-07" version="1">KVINNWPCNPEKTIIAHRPAQREIWSFGSGYGGNSLLGKKCFALRIAMNIGYDEGWMAEHMLIMGITSPQGRERFVCAAFPSACGKTNLAMLEPAVPGWKVRVVGDDIAWMKFGADGRLYAINPEAGFFGVAPGTSHKTNPMAMASFQENAVFTNVAETADGEYFWEGLEKELKNPVSFAQISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY77</accession>
    <name>A0A183HY77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12439</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039844">
        <property type="protein sequence ID" value="VDP11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY77"/>
    <dbReference type="STRING" id="387005.A0A183HY77"/>
    <dbReference type="WBParaSite" id="OFLC_0001244001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001244001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001244001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001244001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1083" mass="124562" checksum="EE161D9FAE3698E0" modified="2016-09-07" version="1">MCSYGLCAVVTHMEKVRTTQYTIQNWIAENNACKKALWLRRDGFSVCLMAKTKEPPVSLLLPLDSCFDVRILRIDYTNGFVFVRPLAEDDRYQELQQKLTKHSLTEHVRAENLNEDSIYLASNNGEVFRGTLIGQPSAISLLYGIDVGDMKFIDAQNIYQLPTDLQSIPPLCFCGLLPNCTTSLEYEDLSLINENNICLCKIYKILPPHFSNYPTVMYPPVVFIQLYKFTGFHNKYVEVIFKHKSRTIINNNEYFGSQCVVSSDSLVTKKRNDQNIEKTINVFQRTSQSYDEFGKADENDTCNEIECFTFKPYNIKLPSQVRAIVTAEIRQNVYWMRDADILSILFENLVDPGKHSKYESVNLVECHDEICCLVRLTKPFKECSSYVRFPVYRAVVTDFHDKTGTCLAYLVDFGLSVVCSTENLYSCKEQPVVIRETISAAFRCHVSQVLQQGSNERKTPKVRPLSVSHFKSNFQKFQKEKDRTNLYQYQDNILTTCAGRICIHFQLLREELYTLQLSCLHNNFYVCDIMSVMQCLKQESESESIDNDIRNGNFKNLTSESTSIEASSSKAVSSERCNVEQNNQRWFQSQPNNLYRGNKSARNEVTLTSIQLDVLKISEKIDNITNAKLASIHMVSYGFSTFGRLSNGLGVSKSNYNLHERKDNHNCWFNIKTGGLMTFTNSILKDRNRNATHMVRNLNDCWKCRSHRIMENGQLPLKLSHYVQPKHMIPSIIPVAVPIAVPLQCPSNCEIFNKRRDGCTQYQHDKHGCGQLNGNKLKIKRTNFHEEMRRKKLKNNIRVLKKWQRDKHYEDRPLSNKKILRTFYVRRLRNREGKLLYTSDESSTDESPLGDAQCQFLINDDDAAVENKIDVASDLLEKELVLNIDEPFVQSRKYAPAYQAFFEHVKVNEGDEVLVKRSDDDHNNKNWPLFFVQIQRDDLLDVLEELDSLQPTISISEEELQVGTLCLSFCHTFESMFRAVITKISNTGIEVYYVDYGNYETVNRNDLKSISNLPDIACTYPGMAIPCMLFNSCVAATLPNYVEAEDGIVTKLKSAVSCDHHSFRIRILKIHEDGVCIVKYISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYJ8</accession>
    <name>A0A183HYJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPAP1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12560</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039867">
        <property type="protein sequence ID" value="VDP11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYJ8"/>
    <dbReference type="STRING" id="387005.A0A183HYJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001256101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001256101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001256101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="3">
        <location>
            <begin position="351"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001256101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="605" mass="69583" checksum="65312BC093B88A94" modified="2016-09-07" version="1">MFKKRCKERTPDNKNSFAEKSRQIDKLAGRFSLDLDSLAEEEANIIQLTVQERNIEFLHNIDQLYDCSSSTTCGDYAKEEGFPDVLDLSKYYNSVDNSVKNFSANGRSFFAIEFDRMHDHDKAEASTSVVAKPTMNDINGEIELENLQRIEKMSKQEIEKAKQEIVERFDPKLLDFLRNRAKKKKQWSAKQTDPIVVPQQAEKSTGRTSGVTSDICTNTNQEVTDKIKELEIFDLEKNNSAFHEDSKTNKLDSSYMRLAADAAQMDMATKCMRTILPRQQQNIIRLFDNLKIPPKDYAGDDDLLENARANLNAIKGLYLEQRKEKGGNLSVHFAEGIDPLGRTAWMLSPIRKVLDVMQKDRKSTLQDLVIVRLSLFWTLLIMVERPTLYYAFATPGEIFVHLAEIFIMGPEIFKDECISQCLSRFLHDYLEPKARDGHLRLVLKEPIAGLDSFGSFYEDLLQHFEEFSMGDENFTLFILLGAYANQRSLDSLLMKCAIWTPNRNIVRQMVVKKDSGAFLLNLMAARRMNEDGVIEMKYFSQFEKLLRTYAEAIRDNIIMKNRNQLLYEIASSELGYFIQLRMTRSIDEKIGSVVLLQFMFILGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH2</accession>
    <name>A0A183HZH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12884</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039963">
        <property type="protein sequence ID" value="VDP12396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH2"/>
    <dbReference type="WBParaSite" id="OFLC_0001288501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20122" checksum="42AB52676548BF10" modified="2016-09-07" version="1">MELPLKYCVLRYRKRLITKLGKLNKMLLLIVFLILAPALSFGMNSLGYGWSIPPYGAANGGYGYAYGNQPYASSYYQPQPYSYTSNLERISHGFRNYIYPAYYYLPRFRKLRSLTSLSKIYILEASVESLIVYFHHRICWLTSKGDGNCNNLSNLLKSGAYGALKGAGAGAAIGGIVGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0K3</accession>
    <name>A0A183I0K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040117">
        <property type="protein sequence ID" value="VDP13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0K3"/>
    <dbReference type="WBParaSite" id="OFLC_0001326601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001326601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001326601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001326601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3907" checksum="5D79A06B1E1E4299" modified="2016-09-07" version="1">MTQAIVRISTRSVRVFSEINSDRYCSFKNVERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1E5</accession>
    <name>A0A183I1E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13557</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040264">
        <property type="protein sequence ID" value="VDP14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1E5"/>
    <dbReference type="WBParaSite" id="OFLC_0001355801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001355801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001355801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001355801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70033" checksum="EF1B8984852EF40F" modified="2016-09-07" version="1">MGDVGTEFCFDNPMILAPIPQPISGTNYLHCYYSILKMFDFKEGMDEEPSSSSENPNSNGTICSDEIAPAILSTSGTWLRLSMPYFPKKSVVWRYFDLYESDGYSRADTERIVKCRLITCMRKELRLDAQSSTKGMWEHLRNKHPDEALKCENGSIAPQEEPSNTGAMESAAATNQQILVAPNPPVSDVYAPYSSLADEKKYETIHRLIGKLLASMQECQDRVHISEQYTLLSFADYARLLTKAKTTTQFVCRDAPMILPEPGTIVIYDSKDNSDLDIDMLQIREHLRQDGYSFDNNDSGLLPDNLYITRFFNGNGDDFEDGRIMRYEVTTTFEDAGYVLFHYVKGTKYEVESTGSTDEIPVHCYKPKAGRLRRIDENRRKADVSLNRGSPVSQLPVKIKRNELDGLQAIAGCLPPGFQTFLDKIRMETDRDENLNGMDLSFEENVEAIGSGLDDSQIEDNCVGITGLLTSSYPNRDLKQTLSVHDVKTDTKVEKRVMNILKKAVRDQRRSKVHYLARRTKNVNWVKVADQLQKKAVMIAAVASNGDAKETGNVITHEFEEEEEEGHDCKNDINDDGDDDDDNNDGNDNDGNNEHVNIFPNYDDSPNCNAHLLNTLDSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1J8</accession>
    <name>A0A183I1J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040292">
        <property type="protein sequence ID" value="VDP14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1J8"/>
    <dbReference type="STRING" id="387005.A0A183I1J8"/>
    <dbReference type="WBParaSite" id="OFLC_0001361101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001361101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001361101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001361101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="640" mass="72547" checksum="AC8A3343993782FF" modified="2016-09-07" version="1">MDEDAMLEFRINGEINGDAACLTKLENTTESISSPSTPGVEISSSLSDTTITLIRQEFENESYITKPKIIDQNHAENFIKSHEQISDSRDSSDSRRKFRVLGLSFPGEWMTNEKFWDLLEKSESFHMWFDKTTKGSIKHGGLSIVYETPGEAKLAFAAFHKMMFDGNSLKLQASKLFYDPIPNSRTVQPPIPFKINLSDPDASKRLYALHLSSATDQTLLSSIFGSECIETVQLEADPFIASEKQAEIVFHTVQEANDARMELADGFEIDEGDRQLTMRLLTMDEYISYMKTENDKILNARVVPVSAPSVPSSSSSQPSPSVSSTAIAATSETAVVPFIPAPEVTVEDVTGFVQQYVDDTRTNWAELNELNELWKLCDEVSQLHRGIPDSLLKVALLNVLERHQRTLPTHWMRQHVDDLIRIWKKEVQNTKGVHRSTSYTMCAAPYIPYDAPERKSSGKSMTRKRALATIMGVGEVLAKVRTMLATEEGELDVDEDEHGNYTIDGQPLSFESWANINKPVKPAPVYERPIPFIDPKMRKLRNQWKKETWQKKMEEEKIRKAQEVNQEIENEKDEENEKDAPDGEIVRAETETPEIRRELEEGEMSSESSSSSSVSTSSDEDVDDGATSRHRRRKRRRHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4H3</accession>
    <name>A0A183I4H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14635</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041024">
        <property type="protein sequence ID" value="VDP17976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4H3"/>
    <dbReference type="WBParaSite" id="OFLC_0001464601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001464601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001464601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001464601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8710" checksum="F00A211BC57B6B83" modified="2016-09-07" version="1">MERQENVLKPKRRKQSNTWDVKRRELPRNSSHPYFTESSKKNTLSDTVRQINIHPTMKMKSLRPKKWLVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I512</accession>
    <name>A0A183I512_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14824</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041247">
        <property type="protein sequence ID" value="VDP19028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I512"/>
    <dbReference type="STRING" id="387005.A0A183I512"/>
    <dbReference type="WBParaSite" id="OFLC_0001483501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001483501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001483501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP19028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001483501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19650" checksum="18B4FBAAC8BED952" modified="2016-09-07" version="1">MGIKSSKPKLSKEDLDFLKKNTSFTEEQIKEWYKGFVQDCPKGHLTKDQFIKVYKDFFPSGSAEGFCEHVFRTFDTDNSGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDIDGNGTIDEKEMIKIIEAIYEMLGPEVTKSADDSPRKRAKMIFEKMDVNNDKASLFCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5C9</accession>
    <name>A0A183I5C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrgI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041385">
        <property type="protein sequence ID" value="VDP19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5C9"/>
    <dbReference type="STRING" id="387005.A0A183I5C9"/>
    <dbReference type="WBParaSite" id="OFLC_0001495201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001495201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001495201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001495201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11457" checksum="111B63E028AA6756" modified="2016-09-07" version="1">MTQLAKLQHAYPYKAVASLAVILVSGLSAYRHKNLLYLIPGAIALPYIAYETDVSSGQGTERIKKRADLLYRKRLTEHEPQLLMADVKQCLKELQERSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5E2</accession>
    <name>A0A183I5E2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14954</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041404">
        <property type="protein sequence ID" value="VDP19737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5E2"/>
    <dbReference type="STRING" id="387005.A0A183I5E2"/>
    <dbReference type="WBParaSite" id="OFLC_0001496501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001496501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001496501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06492">
        <property type="entry name" value="p23_mNUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP19737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001496501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23952" checksum="BF871F479DF2054D" modified="2016-09-07" version="1">MKNGNVKTSSAAEDNNKNKDTENGEEEEDPEDKGKLKPNSGNGCNLEKYQWTQTLSEIEVRVPIKVGFLLKAKDVIVEFSKEKLKVGLKGHEPIIDGSLRAAIKVESATWVLEDRKVVVLTFEKMNNMEWWNRLMTTDPEINTKKVQPENSKLSDLDGETRQMVEKMMYDQRQKELGLPTSEEKKKRDILKTFMEQHPEMDFSQAKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I610</accession>
    <name>A0A183I610_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15172</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041712">
        <property type="protein sequence ID" value="VDP20681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I610"/>
    <dbReference type="WBParaSite" id="OFLC_0001518301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001518301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001518301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001518301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12759" checksum="7308FB04454318AA" modified="2016-09-07" version="1">MADYFGMKPVIEKCEEVIIKQANTLESIKLFQIACAVAEHDRYSPTMTLLIDKLSTMKREELSKLRFSQASDIFKMFSLLDLVPGDVVADVFAAKMKRREMKRKKWCCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7K6</accession>
    <name>A0A183I7K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytospin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042708">
        <property type="protein sequence ID" value="VDP23447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I7K6"/>
    <dbReference type="WBParaSite" id="OFLC_0001573101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001573101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001573101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001573101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="27049" checksum="0A386E751426B470" modified="2016-09-07" version="1">MANSGLVSTSSQLTAPSEEIDKGLETRASSLNGHDASVSTNPVAGTAMHAVGVSQQSRTTASVNTVTSTSADWTTQLKNDLGIGGAAPATKPSVNQPGLMSKSPLQNTKVNQVPRTTSQHTTHSNTVEFVSGEVNGPTLPEYQFGFHVDSATGSDEHGDAVYCTSAKSRSLNNQTAKTEMNADSSSSILSNGPVGDYSSPINSQQSKMSAGNGNVSMPQSSPAVHQTSTIQRQPVTSGLSYADTSSMSYXXXXFYYDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7P9</accession>
    <name>A0A183I7P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BUD13 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15761</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042812">
        <property type="protein sequence ID" value="VDP23715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7P9"/>
    <dbReference type="STRING" id="387005.A0A183I7P9"/>
    <dbReference type="WBParaSite" id="OFLC_0001577401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001577401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001577401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001577401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9957" checksum="6FA1E1C22DB4992D" modified="2016-09-07" version="1">MSGKSAGLKTLEAHRKEMKQLQEDETERSQKLNEMARVAQEDFARHVDDKAMNEHLKEQLHAKDPMYNYVKKKKENAEIKSGTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8B6</accession>
    <name>A0A183I8B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS15978</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043445">
        <property type="protein sequence ID" value="VDP25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8B6"/>
    <dbReference type="STRING" id="387005.A0A183I8B6"/>
    <dbReference type="WBParaSite" id="OFLC_0001599101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001599101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001599101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP25544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001599101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7492" checksum="8BB92512A5826305" modified="2016-09-07" version="1">MSRRQNPSEFLKQIIGKPVVVKLNSGVDYRALEQTEEYSNGQLKNKYGDAFIRGNNVLYISTQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8C5</accession>
    <name>A0A183I8C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15987</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043476">
        <property type="protein sequence ID" value="VDP25637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8C5"/>
    <dbReference type="STRING" id="387005.A0A183I8C5"/>
    <dbReference type="WBParaSite" id="OFLC_0001600001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001600001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001600001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001600001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14198" checksum="A1D711A31CF907B2" modified="2016-09-07" version="1">MLIAEESAFQVIFDTLISQCRKYLKTPDKTQFDFSARSYPHALRRALYMLCDQRYLLSVVPSEQEWTPRLRENFLCGCTSLIRFLSFMQEFIHNCLMIQLINELETAANRSSDYASKIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8D1</accession>
    <name>A0A183I8D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U1snRNP70_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15993</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043508">
        <property type="protein sequence ID" value="VDP25736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8D1"/>
    <dbReference type="STRING" id="387005.A0A183I8D1"/>
    <dbReference type="WBParaSite" id="OFLC_0001600601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001600601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001600601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1 small nuclear ribonucleoprotein of 70kDa N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001600601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10474" checksum="C7CB52BA01715D75" modified="2016-09-07" version="1">MTQFLPDNLLALFEARPPLPYKPPPDELLVDRKRPKMSGLSEYIHLFEDPKDTPPKPVYETKEERRARRVSEIYFWIWISYIICSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UX15</accession>
    <name>A0A3P7UX15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000378">
        <property type="protein sequence ID" value="VDO27594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0B5"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="537" mass="59017" checksum="3EC24CB4ADF6FB0C" modified="2026-01-28" version="1">MDIVDIVVLIGLLVAISFFGLFTALSGTKQTSAAQILHGSNVSVVTSALSVCSGFLSAVSLLGFPAEIYYQGTMLFWYGPMYVIAFPIAAYYFLPVFYNMKLTSIYEYLEIRFNFACRFLASLTFCIQTWLYVSVALYAPALALSTVISIPLSISIFMTAVLAVLYVTLGGAKASIYTSALQMALILASMVLIFSISLYHFGFNSILKTAVAGGRLQLLDFRIDPRIRHSVWSLIIGGTGNILCLFAANQLTIQRYMAMSSLRSAQCQKTKQLFPYFVIDELSTISGMVGLFTASVYSAGLSTASASYSALAAVFIEDVIKQFQMKVQKHEPMQPNTSILLARYLPLLFCCLSMVIAYLCSIMDTMVLQVSFSIFGIAGGPVLSIFCLGMFFPKIKGFAAFIAQLASTVFCVFIAAGALLNHVRPVGLPINEICEGNNVTLEFVEKLEYGMVYPLQSNSWLIQLFRISYQYYSICALLVAFIVAHIVQCFSGYTEHFSVEAKLLSPLLQSTHKRKEIVLDYASGIKKDGEIPLGTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V5E1</accession>
    <name>A0A3P7V5E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004466">
        <property type="protein sequence ID" value="VDO42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HCS3"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="129" mass="14004" checksum="16944CDE75B26D46" modified="2026-01-28" version="1">MATDSGFGSKAYPIADISLSQKLLDLAQQAQSYKQLKKGANEATKTLNRGLAEVIIMAADAEPLEIILHLPLLCEDKNVPYVFVRSKAALGRACGVSRPVIAASIIQNEGSQLRSQIQKIKEEVEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VY49</accession>
    <name>A0A3P7VY49_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008645">
        <property type="protein sequence ID" value="VDO53301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VY49"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="251" mass="29193" checksum="CF80816801B47F6E" modified="2019-02-13" version="1">MILFLERKISPPSLDLNLCTPEEIIGNKFELENDNGLEDDDDRYEEWERHETLHDDVTEQERTKSIKYEAEQEVTWEKGGPGLVWYTDSFFWNELEEGTDSDWKWVDDWDVDYSIYYDRKDGDLDAKQSVEMMEDQKSGEVVHSVFKKIRKRHYESIQRPSSAISSGQFEVHTRGIGSKIMKSYGWSPGLGLGPQNLGRIETVSVEIEEDGSAQTSNERKGLGYRGKKLQRTGFFKPKNHTIATKYIIMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WD23</accession>
    <name>A0A3P7WD23_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010926">
        <property type="protein sequence ID" value="VDO58900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WD23"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF25">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO58900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="138" mass="16110" checksum="59D2198DCAB8CF2F" modified="2019-02-13" version="1">MCSPEKKKKGKDYKKLVYASNYFTLKLSISFLDHNYSGFESKYLHFQQHAIDFKVQHRTIKNFILANLPRENEQLHPCEICGRNFVKNSLVKHELVCRKMAKAKRKVFDSGKQRATGSDITIDNVINARKEREMVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XFY5</accession>
    <name>A0A3P7XFY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000471">
        <property type="protein sequence ID" value="VDO28232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0T8"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="582" mass="66802" checksum="C372A00195351F68" modified="2026-01-28" version="1">MELLNEVIRPLRRSDKGGGWNVLVVDRLAMRMLSACCKMHNIMDEGITIVEDINKRREPLPSLDAIYLIAPTRDSVEKLIADFTYSRNQYRCAHVFFTEACPDQLFSTLSKSRAAKCIKTLKEVNIAFTPYESQVYSLDSPDTFFLYYNAQKQGGLTTNLERIAEQIATVCATLGEYPLLRYRADFERNVELSHLVQQKLDAYKADDPSMGEGADKARSQLLILDRGFDAISPLLHELTLQAMAYDLLDIENDVYRYETGGNDSIDKEVLLDENDDLWVENRHKHIAVVSQEVTKGLKKFSENNAGMKADAKSIKDLSMMIKKMPQYQKELNKFNTHFHLAEECMHKYQQGIDKLCKVEQDLAMQVDAEGERVKDPMKLMVPLLIDPAVEPPDRLRLILLYILSKNGITEENLDKLLQHANIDVVEKDTLANAMYLGLNIMVDQGRKRFWTPNRKERANEQVYQSSRWVPVLKDILEDAIDDRLDMKHFPFLAGRQTTPTYRPPTSARYGQWHKERGHQISYRSGPRLIVFVVGGVTYSEMRVAYEVTKDKKPWEVVIGSDQLINPAAFLENLRGLNKPRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AKI8</accession>
    <name>A0A3P8AKI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040460">
        <property type="protein sequence ID" value="VDP14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="110" mass="12939" checksum="5578F5DF1AED7F35" modified="2026-01-28" version="1">MMIYELRISARSWGSFTDFIRKQYPSTSKIASDRRILSTSDFQQPLSLTVFLFDLSLDGAFLVLVEMLCATECFHPIDRRHFNRKHCLVAFYSSFLFTLPVEDRLRTVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BZ36</accession>
    <name>A0A3P8BZ36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040370">
        <property type="protein sequence ID" value="VDP14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1Y1"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="265" mass="30513" checksum="4BC94429E368B94B" modified="2026-01-28" version="1">MPSKKIIKKRVAPPPPIARKSEASKKEQNPLFEKRPRNFSIGQDIQPKRDLTRFVRWPKYVRLQRQKAVLMKRLKIPPPINQFRTTLDKQTATQLFRLLDKYRPETKHQKMERLRARAEARVAGKCEEVTKRPPVVRSGVNHVTKLVEQKKAQLVVIAHDVEPIEIVLFLPALCRKFKVPYCIVKGKARLGQVVHRKTTACIAIVDTNPEDKTALSKLKDTVITNYNERADEIRKHWGGGVMSARSQAKKARIEKTRAKELAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXT2</accession>
    <name>A0A183GXT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS42</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000010">
        <property type="protein sequence ID" value="VDO24318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXT2"/>
    <dbReference type="WBParaSite" id="OFLC_0000004101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000004101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000004101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000004101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41180" checksum="796730A820BB1C39" modified="2016-09-07" version="1">MTIGFRPFPLMPQSNGEQSGWRQSLAALLCILLCFIVLLSVCCIGIYLIKDKPVYEELVDYLDKSIAISKINYNQQLGFFELEENELQTLEQHRMYKTLLWSFLFAELGCYFFLAISILIYLTMDINRGKTHIVFWLFFVLAVLYCVTEVHVLAFMIFPFASLLPEVTEKLLNHAIPYNPGGLIQMEQRLGCIFDLNLYAAQKRKQNPLNTCDPYISSAFIGKGTLWTLLALRLIPVVIFVILISRKTILSEAVASIGQRFRAAIRSDNPRTKKINYERNFTNSKMTVIGIPSTASPLPNVATPQPAVSSPADNNHSISYNNAAFFATSGAPGVGGLNSSRSSEISRSDAIDLYRPSVQTSSSIMSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXT9</accession>
    <name>A0A183GXT9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS49</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01000012">
        <property type="protein sequence ID" value="VDO24336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXT9"/>
    <dbReference type="STRING" id="387005.A0A183GXT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000004801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000004801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000004801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000004801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31208" checksum="C5C087E7FC386CA1" modified="2016-09-07" version="1">MGHSQQVADIYAGQSVFITGASGFLGKVLIEKLLYSVDSLKNIYLLIRPKNGLGPKQRLDTFIQGPLFDRLRRFNPGIFSKLIPVGGDIVEEGLGLNQLDMQTICDEVSIVFHCAATVRFDEALRIAIEMNVLGTQRLVALCHMIKNLLVLVHVSTAYANCDKSEILEIIYPPPVPPNKLFEAIDWMDDVIIEAITPHLLGKRPNTYTLTKALAEVRLSQVCYKLSRYIKVLRKKIKMMCLVQLMEDAGRLPVIIVRPSIIGAMWQDPLPEIRERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXU8</accession>
    <name>A0A183GXU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS58</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000014">
        <property type="protein sequence ID" value="VDO24366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXU8"/>
    <dbReference type="STRING" id="387005.A0A183GXU8"/>
    <dbReference type="WBParaSite" id="OFLC_0000005701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000005701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000005701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000005701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10353" checksum="91913840987F10BC" modified="2016-09-07" version="1">MHYYCPENYNEGYGAIYAVLRKIFNEMLGNIHSNPATAKRLTQLAVRDKFSGFIDAICSNQPFSYVINSDLYCEVQKFNVTCLVFRQAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYF2</accession>
    <name>A0A183GYF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BSD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS262</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000074">
        <property type="protein sequence ID" value="VDO25174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYF2"/>
    <dbReference type="STRING" id="387005.A0A183GYF2"/>
    <dbReference type="WBParaSite" id="OFLC_0000026101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000026101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000026101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000026101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43657" checksum="40A81DD02EE919BC" modified="2016-09-07" version="1">MGENYDEMKSVENATEMETVASEKNPINNKKEKAGKNIYSFQGWVSTGSAWFRSAKEKTYTTFELVKKDLTEFGDVVANEASALANTTVESVRQQAYNLQQIMNLEGENNEQNKEEREKVESTTNEIERSSSTYAIEWASRLSSLPTITDNSWIKTIVDTVKNIAQENTADGEDEFTESIYPQIKSTGRSCLAHHILYEIQTNPDTYMKIPEGDKELFKMWCDDFKLIEYDGEINALLANCPRMRALYQEMVPEKIENVVFWARYFYKVYQMELLVRCKFDAEKQLSQDDENGTIQRQKRMTNFGEKSSNRIESCLNVDTELTQSQSSLDRRSAIDESWSLCSSTNVDIQELHDENGPQTPKADSNNSSNKSDGWINWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYI3</accession>
    <name>A0A183GYI3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS293</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000086">
        <property type="protein sequence ID" value="VDO25285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYI3"/>
    <dbReference type="STRING" id="387005.A0A183GYI3"/>
    <dbReference type="WBParaSite" id="OFLC_0000029201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000029201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000029201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="4">
        <location>
            <begin position="116"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="5">
        <location>
            <begin position="429"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO25285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000029201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="553" mass="60460" checksum="C8F7318322376510" modified="2016-09-07" version="1">MAAWEEYLANQANIDGVQMTWNLWPHSRIDAQRLVVPVAAFFTPLKERPSDQPHQPSLEYDPVLCQKASCKAVLNALWLRNPFPPHYNMIAEDNRPPELYPQFTTIEYTLKKATTLPPIFLFVMDTCLSPEELKALKESIQTALSLLPADALVGLITFGRMIELHELNVQGISRAYVFKGTKEINQKQVRDVLTMNIGRPINAGATPGSHQQLGSGTSGPTTQQRSGFPMGSTGVPGGGPAVVQGMTGSSLLPFNKFLQPISDCEVSINDLIEQTVPDRWPVPQGHRPLRATGSALAVAVTLLEVCFPNTGARIMLFIGGACTHGPGAVVGEELKNPIRSWHTIKEDNAPYIKKATKFYDGLAARAVKNGHVVDIYSCALDQTGLYEMHACFNTTAGNVVMGDSFKSSLFKQTYQRVFEKDCNGFLKMGFNATMEVKVGNGLKIEGVLGCCANGGVKNASVSDTEMGIGGTCQWKFCSISPRTTIAVLFEIVAQHGSGIPQGSHGMMQFVTQYQHPDGRKRIRVTTTCRNWTDMATQQPSIAYGFDQVIVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ81</accession>
    <name>A0A183GZ81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000188">
        <property type="protein sequence ID" value="VDO26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ81"/>
    <dbReference type="WBParaSite" id="OFLC_0000054001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000054001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000054001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000054001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24946" checksum="5ABEDE460728DA29" modified="2016-09-07" version="1">MQTAIQDLSPLDANDREFRNNLLELYLSCSVLSIGISAGEISGALVLGMIYQKIFDWWWELLLIILLPCHVYLTFRKNAALDETERRVNLFGLGLAIGSCLGHMMGYRLISTLPSVNFIQPLILALMVDPELSPSTVYSQRQNLLAASTGAGIAVATLLGMIHGLSFCIILSIAIQAAFLATHFQVVLYTMKNKSYGVGEAQLCYVLGSMITQIPLAVVFGTSNIGSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZF6</accession>
    <name>A0A183GZF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000216">
        <property type="protein sequence ID" value="VDO26413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZF6"/>
    <dbReference type="STRING" id="387005.A0A183GZF6"/>
    <dbReference type="WBParaSite" id="OFLC_0000061501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000061501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000061501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SULU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000061501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="574" mass="67673" checksum="1FF1E0AA34F74382" modified="2016-09-07" version="1">MLNLKKAFPEKLKAHKMSWDDLLIGGLIIFWGGSDKVSCQEKYQTFFTRSEAPGSAKQMGRNEIRGKFAKAMKESFQYVISDIRDEWHTEITPEKYVTGDLLFEGRYSSVVTAKSYPTHNGCTYVEPRPCVIKTKHIGAILDDMLHDLHEAKEKFQRKISRLVRRIVMEIYILNRVRHSNIMHAHATVVNEHSLCIQLVLPRLYQLEQLIDKYRGDNEGKPMNIRIIAMIIRQLCRALSYLHDANIIHNDIQPENIYLTRGGTVKLSNFMNSRMLVSERMAEECRTPDGVPDYMCAEKQYNLKRVINITDYKNYSTSADIWSLGVLILHMVSYYPNERWHRLPQMFALQMNENRMPFRWMINDMMQLSVRMAQSGDRHLKQYLNDTVLNLDPFARPTAKQILESYLITKWCNKCLEQDKNHLVKRFIYELDWQNRTKLDVNGYNYNACEAKDVPADFYWDNTWRKLEQLSFAYRLYVYDHDNLRIGSEVERYFTHADNSLFQTLMLAVDTDHLEMFDVIPVDQNIRNLCFSLMRIAKYHRYDLAKCEAKEVLFDLPPSFQCDVRSAKVVVYFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZX5</accession>
    <name>A0A183GZX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS785</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000304">
        <property type="protein sequence ID" value="VDO27059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZX5"/>
    <dbReference type="STRING" id="387005.A0A183GZX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000078401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000078401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000078401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="341"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO27059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000078401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66253" checksum="DF44ACE191355853" modified="2016-09-07" version="1">MMGTMVSSPSSPEPEEILTTTESLLITLSQKPLRMSNMLRMIRIISDCSPEEKLQLFHAGVLRRICETIAEYGGINKLDRPEFVQNRRRIRQQSAGRNSFSVHIQKGIGYGYGSTRSRWNIERTVEERLIREEHLVWLLNAVTAFIYCASPDFSSDVHLHFIDRYPVHLSKPIVRALLETAATMSLVPALIPYLVHPINSSRSIAKDLMLRFSNIMASYPKSFKGQMGSLDLRFNDFITKAQQYSQVVVAAAHRYEQGIPIEKRVQTAAIRTEDSETLLMGRCDEEISTERENLSILYHKTLKKIQVQTFRFIGDYGKLSVPFTFKKEVRNVNPFSASLKERTRRIARELASMPNSLPLNASNSIFVCLDEGRCDIVKVLISGPDDTPYQNGLFEFDVFFPTSYPLSPPKCAFLTTGEGNVRFNPNLYSDGKICLSILGTWEGRPEEKWNAHCSLLQILISIQGLIFVKEPYFNEPGFEKYQGTEKGDDFSKHYNLQIEYATLTYAIREQVKKSPPYFKDVIKRHFWLKRHSVIEQAQNWLGKMTKYAAQTEKHSQKNFLLPFETATNFLTQVVIQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0E0</accession>
    <name>A0A183H0E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scaffold attachment factor B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000392">
        <property type="protein sequence ID" value="VDO27690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0E0"/>
    <dbReference type="STRING" id="387005.A0A183H0E0"/>
    <dbReference type="WBParaSite" id="OFLC_0000094901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000094901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000094901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000094901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="21170" checksum="E3AF8F5FA3D65A4E" modified="2016-09-07" version="1">MSRDDDIYGQRSETRSRTVREIPVQHTTSSIPSSTATGIDYRSSTTPFSDYHQEEYYRKEIRTRTFITRSAETLSAPPLSRSSPIILEHERYPSCDNKYYPREERTVDYNYKYLRSLEEEERRIKKDQEERQREEEDRRRRAEEERRLWEIKEREYLERKRHEREIKVLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0F5</accession>
    <name>A0A183H0F5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS965</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01000400">
        <property type="protein sequence ID" value="VDO27736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0F5"/>
    <dbReference type="STRING" id="387005.A0A183H0F5"/>
    <dbReference type="WBParaSite" id="OFLC_0000096401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000096401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000096401"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="9">
        <location>
            <begin position="40"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO27736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000096401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="572" mass="64491" checksum="3AF2BA92B937A972" modified="2016-09-07" version="1">MAVSGFASSILSKIHEIVSGGAVSVLHNYNGRNDAVPGPSSMMQIQDRRLVEKTFKLMDNVVKHCQQPRLNLKNSPPFILDILPDTYHQLSSIISKNPNILKDNAYLILFLENVQLKCKQAMKLFKEDRERIYDERSSARRNLTKLSLIFSHMLAELKAEFPDGHFIGENFRITKKEADAFWRESFGIKTTVPWFEFRVALSKVHRLNTGLETLALKTTIDLTVNEHISNFEFDVFTRLFQPWNTLLHNWQLLAVTHPGYVAFLTYDEVKQKLQKYSNKPGSYVFRLSCTRLGQWAVGYVAPDGKIYQTIPQNKSLIQALVDGSREGFYRFPDGRPKNPDLSHALQPNPEGHVKVSKVTPEQYQIYCEMGTTFEMCKICAENNKNVKLEPCGHLLCTPCLQSWQESDGGGTCPFCRCEIKGTERIIIDSFDPIEANKKLGYETIIEKSNIKNVRQSWPPRSEIIPPRRAPPLPPRYDSSSAGNSPSVSHKQLTFDASVANDNNVLAQNAEKFEQTGNQQSYQDAISNSISQLKVLTPTTAEGSSYVNVITSGAKSNCEGLQYVNTAVINGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1P4</accession>
    <name>A0A183H1P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein regulator of cytokinesis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1404</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000652">
        <property type="protein sequence ID" value="VDO29410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1P4"/>
    <dbReference type="STRING" id="387005.A0A183H1P4"/>
    <dbReference type="WBParaSite" id="OFLC_0000140301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000140301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000140301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000140301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="525" mass="60869" checksum="35CED6A7AF8A802B" modified="2016-09-07" version="1">MTKESLSRRRVSINFSTAEAVSSIRDTIDRLNQLWDRVSMEECMRCRRIEKFFLYISDLLNQMVADEEEMVEGIQEGIKEMNKQAEDLCKELHLPLTNRIHMKPGSLALYRALHQDIGRLRSLKDDKLQGQKKLVEELAKLAVQTGEEIEDLPSSVVVCDDATISCLQNRVSYFNELLTERMEKCKQWQMDMKRWYKQMGGTPSKELGKTFTVLDLDSEELVWDKHFLDEFENAFDEVKAEYNEWIEQACFDYTETLLRLSELWDLCHVPDVERNIAREFNPSIHTVHDIQHAKEQVKSLEKFLADRAEVYKKMKEWKDLWNEKVEFERSANDKSRYHNRGCELQTALKRQKFIANRLPIIQNELKVEVEKYESTHDNHILMDGLSPCEHIESIMEEYRINKELERKRKKQVEVFTGSVSNISNMITPKKRGVPSTFVTPCSSAKIAKVKPLTRSDQATSKGPDMLLSHIKSVSASTASLHSVITPVRPPTTGPKTSSPIRSVDKRTGKPLKGFNLPPIYKTPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3S4</accession>
    <name>A0A183H3S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2134</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001167">
        <property type="protein sequence ID" value="VDO31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3S4"/>
    <dbReference type="WBParaSite" id="OFLC_0000213301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000213301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000213301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000213301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7978" checksum="0DE1C1B47B4606DB" modified="2016-09-07" version="1">MYDVVRSLSYHGVLSVDIPEKQCSLSFPPCSPPRCHIGDVNGTVRVDCQLDFSGRGATKDRQEKETPQNAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4T6</accession>
    <name>A0A183H4T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2496</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001445">
        <property type="protein sequence ID" value="VDO33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4T6"/>
    <dbReference type="STRING" id="387005.A0A183H4T6"/>
    <dbReference type="WBParaSite" id="OFLC_0000249501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000249501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000249501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552393" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000249501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10443" checksum="9FDD48887256DDE3" modified="2016-09-07" version="1">MLHRLLLLWMIFHGILLRSSKAITKSFVNSSMLDMRPTFVVNFDTSTVICQHSSHPDDLHLHQISILCDGEQDCYSNPAMHDESFPYCGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H587</accession>
    <name>A0A183H587_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2647</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001560">
        <property type="protein sequence ID" value="VDO33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H587"/>
    <dbReference type="STRING" id="387005.A0A183H587"/>
    <dbReference type="WBParaSite" id="OFLC_0000264601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000264601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000264601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000264601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42107" checksum="47F4E6A678A739F3" modified="2016-09-07" version="1">MTASRSQIIQQAVSPRSVQQQDAAAKLIPQQASAPKVTPQLQQQQQPAITAVSMRGVTQPVVVPPNITPCIPIINTNTALISNAAAATQDCVHNPENSQKEERKSLQRVRQRTITVQSQVSLDITAAYNEVKQMNSDDPATELVRRVQAIVATREKEWTAKNEKLTQLLTYEQKRNEPLEQKAAERLLAMAEYEKLVQEFVEELKKKNSDGGPKSVGRPGPERNLSPDDVTQLIKERDQLAEEVNSLETSYSELFRRYEKLRQTSVEIKRNEESVKNSSEEMARRYSVLAEKFEMLRRNAEEQLDLANNEIDRLIKQHEADTLGLRLKVKHQESKINSLTVSLEARQKELESMTAIFEEVITKAEANDAAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5A1</accession>
    <name>A0A183H5A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001578">
        <property type="protein sequence ID" value="VDO33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5A1"/>
    <dbReference type="STRING" id="387005.A0A183H5A1"/>
    <dbReference type="WBParaSite" id="OFLC_0000266001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000266001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000266001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000266001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10189" checksum="3369EF334D357F6D" modified="2016-09-07" version="1">MPKELKEISSCGGLFEPETVAECLLYNLSRGNYHTCIGLEGWMLGVLSAGAAPEKSFLQAAAQVLFGGLLRAIMLIYIGHFNWIVEKCKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6J6</accession>
    <name>A0A183H6J6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3109</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001979">
        <property type="protein sequence ID" value="VDO35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6J6"/>
    <dbReference type="STRING" id="387005.A0A183H6J6"/>
    <dbReference type="WBParaSite" id="OFLC_0000310701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000310701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000310701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="111"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000310701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="54311" checksum="116E50657A5CCF11" modified="2016-09-07" version="1">MIELRNKWAMEKNWSNEYSIIDNAVPIIFHQFEGLKEKIFVVGKTVALLQLMGMEDDDLHERQRILSSVDPLKCYLYVSAGHRLWYAVTKLSRQMSGKVSQNIVQKYNFHAHILAVERHYLLNDEYFALTFYEMLKKEASNNCDMLKLDSQQVSQAFSATIQRCKSWPKDILKLAKIEATCGLMEEFNEAGDSSYLVASPRDQCGCATIRLNYESKIPISIVLNESAMERYEKAFEFIWRLISTDFQLTAILEDHYCFMKSEPLSDAALIVNIFTVSFARMSQILSIIRSYVSHSIVLNLRAAFFMEIDNICGDLDAIIEAHNRYLRQLEEGLFLNEESTMLRNLFCVVFSLITDLLKHYTAFRSEMTDTIEARKRFSKQQKDLNGKNFYDTKFFEQEEERIRLEELQQHLEEYYQPKVKTLNSKFVLLIRDILNILTAPPRKMHYVELALQLDLTSFYRLCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7M4</accession>
    <name>A0A183H7M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2513 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3483</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002332">
        <property type="protein sequence ID" value="VDO36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7M4"/>
    <dbReference type="STRING" id="387005.A0A183H7M4"/>
    <dbReference type="WBParaSite" id="OFLC_0000348501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000348501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000348501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000348501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13548" checksum="8BADEC4BA742C591" modified="2016-09-07" version="1">MDFQLAEYVHNDSQLFLLEPSGLCYEYKAWAIGKHRQAAKTEIEKLKFEDIPMRQLVNEAARIILMVRDEAKDKNLQIEMGWVGKTTGGKHEVIPKNIIKEAEVWAKAKLEEDDMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H880</accession>
    <name>A0A183H880_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3692</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002561">
        <property type="protein sequence ID" value="VDO37447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H880"/>
    <dbReference type="WBParaSite" id="OFLC_0000369101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000369101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000369101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000369101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="612" mass="67386" checksum="CCC2AA2C0EDDD6C4" modified="2016-09-07" version="1">MIADDTDWNNQDDMVLATDSDTGYNPAGMTEVKHHKRHERRRKVKKNSKKAKKRKDIRKRNVKHNESRNVYKKNVRRKKRRRKNIRKKKSVTGAQKRLAEAIGLNLLTGRQKKWGRNERHFPSSSLRQKPLTAPMLSIRNGDDLDIPVETLSLQSTENLNDKTSDDKPGEDTDLITSIMFEQTKTLAPARYQRILRDGTIGENEQMIKQRKKLINEKIVTCKEQVCSNGLKFTGLFYFSNILNASNILNVSQKFWDWGTIIFCTPYFSFVSRAKSREGGVTLNLMLLQCDSDENVSMYSASSSHIEAKEKRKRRPSRWGTPTTSKSYDTIITASIPLPLGPPLTQSTVSLENIPIPSTDQQPTQSQVALLSRPSALNTTPSTSFPLKSASIPSFGMASGQPQISLAPFAGSGLGQQPLGLNQQSLVTLGQQQLTSLGQQTLAGLGQQSVPGLSQPQLASIGQGSLVQMQPSLLPNFFLPPLNLGAMNSLLAAGLLANNNPLAAPPITQPLAQPSSATTAPFMLNPVQLSTASAQQLNQHFVNLATTLRRNVDVAADSSHLSQQPPKQPEGVPPPPPVMKPSESASNNISLCEPLAEKIRKLIEASNVRPMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8B5</accession>
    <name>A0A183H8B5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">39S ribosomal protein L22, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3727</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002595">
        <property type="protein sequence ID" value="VDO37569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8B5"/>
    <dbReference type="STRING" id="387005.A0A183H8B5"/>
    <dbReference type="WBParaSite" id="OFLC_0000372601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000372601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000372601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO37569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000372601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="15317" checksum="C77B6B37C8A7061C" modified="2016-09-07" version="1">MEFPKSKVEYPAWQIQDFDPCRIMHMTVYTGLGRNQLRKRLIERLHLFADDQMPAFVQKNIGNQMEQVQRVPKRSDEYTMEERSKFPRLFKFKDDHFVDWERPVENPGQWTGKDRSPFNPYYQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Q4</accession>
    <name>A0A183H9Q4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein Nup85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003111">
        <property type="protein sequence ID" value="VDO39304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Q4"/>
    <dbReference type="STRING" id="387005.A0A183H9Q4"/>
    <dbReference type="WBParaSite" id="OFLC_0000421501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000421501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000421501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000421501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42968" checksum="ADB5A0D04EC14703" modified="2016-09-07" version="1">ITNVHWADVVYQRLRRGLGLHEKLSTVEKRRAVTYMVKMIDYCSDSDLAAAVYAHLAANLLWDLYADNGDADALYEMILLLEWVVKNHPSDPVSAIILCKAYSSIGVTTQVQRFMRALDIKYIQRDTLGQLFCLWTAGTVSECLTTAYKNGSFLQIPRLVEFLNRINKSFIAVGVDIQTRALSACFALDKIQLVVDTMYGDEELIDFLGLVDNRDFGIIPSFNTNKEEQKLNEMKQRTYHEQCDAMKLSHLLMKSIAAIGHSKCTLKNLSVFLDQLKKHVEHCRQTYTDDETLPNLLQSPPSLHLSELINTPKIDLLMLLLKSASSVVECSENIISSNINEQVHEEKLLHCLPDVTEIEDLVIGKLLFEFHFSAWKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Y3</accession>
    <name>A0A183H9Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4295</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003199">
        <property type="protein sequence ID" value="VDO39549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Y3"/>
    <dbReference type="STRING" id="387005.A0A183H9Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000429401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000429401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000429401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000429401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50825" checksum="94B79BA350BCA8BB" modified="2016-09-07" version="1">MDVKGYPKKKEKACLKKRFHKVLTNDHLNEYSKLFFVGPKSNWTICSDDDLNVQSPVKEFWDYQVLGISSGIEEPVELRWNLAFYLLLAWIICYLCIFKGVRWTGKIVYITASFPYIMLICLLIRGLTLPGASMGLEFYLKPNFGKLLESKVWVDAVTQVFFSYGLGLGALVALGSYNSYHNNIYRQSLTICFINSATSVFAGIVIFSFIGFMAVEQGKPVEEVAKSGPGLLFLAYPSGILQLPYTNVWSILFFTMVLFLGIDSQFCTMEGFFTAMIDEFPHLIRSKKYGREFFILGVCIISYLCGLNTVTRGGFYVFQLFDFYAASGWALLWLLFFECIAISWSVGINQWYEHIRSMVGYYPSRWWKFCWVYATPIVCMSVMIFGLAKYEPLRIAAYNYDYPLWGHLFGWFLSLSSMLCIPVYGIYLWITTDGTSSEVYSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA50</accession>
    <name>A0A183HA50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Clathrin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4361</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003274">
        <property type="protein sequence ID" value="VDO39751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA50"/>
    <dbReference type="STRING" id="387005.A0A183HA50"/>
    <dbReference type="WBParaSite" id="OFLC_0000436101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000436101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000436101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="144"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="290"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000436101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="552" mass="64254" checksum="450A51D14C714AB8" modified="2016-09-07" version="1">MAADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYIQKLDNYDAPDIANIAVSNQLFEEAFAIFKKFDVNTAAVNLQNTLFLWQMNVLIDNVSNLDRAYEFAERCNEPGVWASLAKAQLKEGLVKEAVDSFIKADDPTAYMEVVSKCSETGNWEDLVRYLQMARKKSRESYIETELVYAYAKTNRLADLEEFISGPNHAQIQQIGDRCFESGMYEAAKILYNNISNFAKLSVTLVRLNEFQGAVDAARKANSTKTWKQVCFACVDNEEFRLAQMCGLHIVVHADELEELINYYQERGYFEELIGLLEAALGLERAHMGMFTELAILYSKYKEEKMREHLELFWSRVNIPKVLRAAEQAHLWSELVFLYDKYEEYDNAAQTMMQHPVEAWREQHFKEVITKVANIELYYKAMQFYLDYKPMLLNDLLLVLTPRLDHSRTLPLVKPYLRQVQTQNNKSVNEALNQVLIEEEDYAGLRASIDAYDNFDNISLAQQLEKHELLEFRRISAYLYRGGSRVLNYARRTNCIRMQWNMLRNLDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAM1</accession>
    <name>A0A183HAM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003477">
        <property type="protein sequence ID" value="VDO40248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAM1"/>
    <dbReference type="STRING" id="387005.A0A183HAM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000453201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000453201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000453201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000453201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51314" checksum="12CCDA0E2397E503" modified="2016-09-07" version="1">MLMMLSWRTQKAPNNKQYFYLTFGIGPNRPTTTVDLTNSETLWNPHVLLASRLQERFNKRRSLIDLVQYLIDSVAPLFALHSFTRIRLQSLRAFCQMMCYDASLALGLQVTITIVDEYRIRLIYGHMHLEFLLLGNSRIGLRDCSLGSACVFRLRQFCSNFLSPELRSMNEEKSPSAFGWTASGSGPGSLPCHQMVRSPASRIVSSPMSHMSLSVPPIDSFGSSLRYSSDGRSKTPILLDHDSLHCMTSVDEFGICPLDEYLFALAYLSKLGPALEGYRREHRGSGAHPIIQFRQLIATPESVRLSVLGAAPPNLKHEPFLVNMNIYLDEETMSLKMKLDFENFLDGEDIPADSDIRTAELYFIRFVARLGNEIAVVAFANACRLAAPGAFSAIARIMSMQMNWTEDTPWRPSIQLVMWSQEGSVPRARISPGIVIDQTNISVLILVRFRNLRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBG1</accession>
    <name>A0A183HBG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4823</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003861">
        <property type="protein sequence ID" value="VDO41169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBG1"/>
    <dbReference type="STRING" id="387005.A0A183HBG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000482201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000482201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000482201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000482201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9817" checksum="9098CD6B3E9D5A55" modified="2016-09-07" version="1">MQGFCDDLQIKAEQLFFALKHHDNSYKLSMKERIPKFRLIKEFTGHSCTKFRCYCTYNFLCDVISTSLSVEYNDAGENDLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCN5</accession>
    <name>A0A183HCN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OB_NTP_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5247</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004411">
        <property type="protein sequence ID" value="VDO42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCN5"/>
    <dbReference type="STRING" id="387005.A0A183HCN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000524601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000524601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000524601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box helicase OB fold" evidence="1">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent RNA helicase DHX37-like C-terminal" evidence="2">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000524601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33932" checksum="837125D496F9927D" modified="2016-09-07" version="1">GSEEECHRLGVRYKALIEIRKLRQQLTKIINSKCPQDKSLVVKLDMKPPTDEEILMLRSVKQIVTASLTENIARRVDPIATESVPKGAYQSQKLKDYVYIDPSSILFKDEPDWVLYHEIVERKDKKYMQNVICVEENWLPRLANTYCHFKPIKEVEPRYDPATDNIVIFMNGTFSDMHWPLGRVEQPLPVNINLYRYFAQFFLDGSICPSLAPYADKLLLSPSTMTKPWAKLQLRTEKLLNALIEYEVTNRNRLLEVWRNKSEYLLDEYLEWLPQFLHENVQMNWPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDQ2</accession>
    <name>A0A183HDQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5613</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004917">
        <property type="protein sequence ID" value="VDO43733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDQ2"/>
    <dbReference type="STRING" id="387005.A0A183HDQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000561301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000561301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000561301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0736">Signalosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000561301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22807" checksum="A23BED22FB25ACE6" modified="2016-09-07" version="1">MHLLALVLIQDDERKFRLLGTFKDTIARKDELPELNEAMLRKIRQLTLVTMCTRSKIFPIEDAMRELQITDLLAFQRLFISAVYDGIIKGRLNAQKNEIEIFSWKNRDIADDELDDICRELHNWIQRCTDIKEDLSRVAKLTENAIVEANERENKVAEEAKKVQKMLEEEEEQRMPKEFYRRTKTQRGKKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF31</accession>
    <name>A0A183HF31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6092</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005599">
        <property type="protein sequence ID" value="VDO45371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF31"/>
    <dbReference type="STRING" id="387005.A0A183HF31"/>
    <dbReference type="WBParaSite" id="OFLC_0000609201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000609201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000609201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000609201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15329" checksum="BCE04D793B3AF9E6" modified="2016-09-07" version="1">MPIFKEASNRFRDRGNAIAWATVDCDREADIAQKYHVNKYPTLKLFRSGELVKKEYRGQRSVDALSAFVEKQLVPSIQNFSSNVELNNRINPKKLNIIAYFDHAVGPEFDNYRKVASLLREDCIFWLGIGEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF32</accession>
    <name>A0A183HF32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6094</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005602">
        <property type="protein sequence ID" value="VDO45378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF32"/>
    <dbReference type="STRING" id="387005.A0A183HF32"/>
    <dbReference type="WBParaSite" id="OFLC_0000609301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000609301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000609301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000609301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13140" checksum="F6752E32C1495092" modified="2016-09-07" version="1">MSLRHRGVNTPQFKQSALAFQPQVKLETGICAWILIITAYIVVFLTLPFSACACIKYKLFQVVQEYERVVIFRLGRLMTTKARGPGLFFVLPCIDSYKKVDLRVVSFDVPPQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF36</accession>
    <name>A0A183HF36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6096</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005604">
        <property type="protein sequence ID" value="VDO45382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF36"/>
    <dbReference type="STRING" id="387005.A0A183HF36"/>
    <dbReference type="WBParaSite" id="OFLC_0000609701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000609701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000609701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO45382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000609701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26895" checksum="C5E78AAA58C13803" modified="2016-09-07" version="1">MSFDSGSSLSSFNTINVFPHRSLTATSTASSTDETHLQTISIYLFSFNPVSNDDQVNFDSHKWATSEELIEKILQQKQELANTSAADYDLYEIMGTMDGQTFKERKLDRNEYPLAVQMLWPRLVHSENIETTPKNRLVLSPEDFSVYFATSRHKNSGQSSSGMHFASTSTSSTIDSFLAKFLAQPPDREYPDLCMLPELTEQTLLDNLKNRFINGQIYTYIGKFFVISISFQKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG18</accession>
    <name>A0A183HG18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ING domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006110">
        <property type="protein sequence ID" value="VDO46520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG18"/>
    <dbReference type="STRING" id="387005.A0A183HG18"/>
    <dbReference type="WBParaSite" id="OFLC_0000642901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000642901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000642901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000642901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38354" checksum="47B084F64842E1F2" modified="2016-09-07" version="1">MEKIVQLYYVIFKRIGTKRSYVRHRKRLNSGQEEQPSTSNQKPKLIFTPFEKLTKEVQTLSMEVVEFEKKAQDRYRSLIEDHSNLQKEVKGLSNKIAEMSKKIDKLYSKGIAIEKCILHEVEMADSSMPELEPNINGTFDDTDDEEKQGETTGAKDFAIDANELNNKPRKRRAAANKREGDYANMLKQNISFHEPKKSVAADASKSREKKGKFLRKESDNGSDSELSNADSKEGTEISPWKMYKHVQIEPRRTDLPKPKIARSGGGRNVHFTDDWKQYATTIYPIDPSRYWNLPQAQYDLLIPVNSTVQNSKLDTILKEIDIIICQKKKPLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGA2</accession>
    <name>A0A183HGA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6514</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006228">
        <property type="protein sequence ID" value="VDO46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGA2"/>
    <dbReference type="STRING" id="387005.A0A183HGA2"/>
    <dbReference type="WBParaSite" id="OFLC_0000651301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000651301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000651301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000651301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="34022" checksum="EB6427F2F133F21F" modified="2016-09-07" version="1">MESLKDIDEMQEQFLTVTPQYVEEARNNTMIMQVKNEETEEKRIDESNLSMQAESFSAAAELQTTEQMRKKANGDESTVETAAKKMLMKQIKNEMQTFGRSNNIHKECNPEQDGSETKIAVQLYFDKIDEKSAGLNNTNNFNNKSGKDQKLEKQSDKTISDERNCEEISDERYGKEVHNSRNGRASSSAKQKGCELKLLKLNQRYGYRTFSTFKLSEQELLQREALYIYNGATFHWYPYKIVGNNPFRVASSEVLRDGEGKVIERFKYKYIVFHCAHYGNPRKRGHVNFFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGI1</accession>
    <name>A0A183HGI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6593</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006356">
        <property type="protein sequence ID" value="VDO47028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGI1"/>
    <dbReference type="STRING" id="387005.A0A183HGI1"/>
    <dbReference type="WBParaSite" id="OFLC_0000659201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000659201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000659201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000659201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29168" checksum="2B220C06508F6817" modified="2016-09-07" version="1">MRVITTGNNGFEDFDFSTFINRDEELARILQNHELAFDESLENGKHMSIAERLQLSALINHYSEVDRERVIECFRDNKFSAEATRNTLEVFVNGTENIQRALFDPSAITSSVNQPDSSTISTGFSHQFASSGLLVSKPDLKSIHEDTCELREEADRYSKQKEEMLKRAKNQRELGAKTFYFAEAQKFGKKAKDCVAELNERLTKANTWDLFVDLHYMDVQSAIKLLKSKLNAADSEFIYFLLCINIFKMNICFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGV6</accession>
    <name>A0A183HGV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006555">
        <property type="protein sequence ID" value="VDO47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGV6"/>
    <dbReference type="STRING" id="387005.A0A183HGV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000671701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000671701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000671701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000671701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18314" checksum="D99F1AEDA8E1215E" modified="2016-09-07" version="1">MQQASGTIEKEVTGRELQSMVMEEDYLYEAMDSTSGPHIERNQTTGDDAYSDGPPVCEVYETIDESSVLESRAGSYDAYRPGSSFTTRATLPPHAKVMMLMKSNTPGEKPRLVKLEPVENPSKPDFRFAFETLRKCVKKSTPLQIPRTRKRRIIQPVVKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH53</accession>
    <name>A0A183HH53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6815</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006703">
        <property type="protein sequence ID" value="VDO47998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH53"/>
    <dbReference type="STRING" id="387005.A0A183HH53"/>
    <dbReference type="WBParaSite" id="OFLC_0000681401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000681401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000681401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO47998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000681401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22272" checksum="88F6914B3ECF0571" modified="2016-09-07" version="1">MLSGNVPFHARSKHESATDIMRRIRNAEFSFDAPQWRSVSAEAKTLITLLLTVDPTKRLSLDELQRHPWLLSSAAQNETPLQTPTTLLKSQLHTEETFNETLNAFLNANREGFHLMEVTAAPLLVKRRGMKRKSFGSREPSPGFEGTTNKRATVIGPLETVPEVASPELSRPSLLFLQSSSINYRNSESPTPRDTEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHW5</accession>
    <name>A0A183HHW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEC63 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7077</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007141">
        <property type="protein sequence ID" value="VDO49205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHW5"/>
    <dbReference type="STRING" id="387005.A0A183HHW5"/>
    <dbReference type="WBParaSite" id="OFLC_0000707601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000707601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000707601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000707601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8640" checksum="1414C86197846F1C" modified="2016-09-07" version="1">MMKLAPDFKFGAYLNVVYKKSGDNGNGSMIVTAKQRLDREAEFPGKQLEIPIILKDSGGLQSERSVYIIIGDEVGDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJB4</accession>
    <name>A0A183HJB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7581</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008008">
        <property type="protein sequence ID" value="VDO51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJB4"/>
    <dbReference type="STRING" id="387005.A0A183HJB4"/>
    <dbReference type="WBParaSite" id="OFLC_0000757501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000757501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000757501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS7 platform" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000757501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13454" checksum="C16F26840E75DDB9" modified="2016-09-07" version="1">MQAAYSRGSAIFSSDNISTIVIIRDILNLNEQSIPHVLQMLHPKLDHRANLTKKLALCRALQELADNVEDLSFLCTNTKEIMDSFDQLHKEMASCDTHFDRLTNIIVNLYIGKNLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJK1</accession>
    <name>A0A183HJK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008155">
        <property type="protein sequence ID" value="VDO52100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJK1"/>
    <dbReference type="STRING" id="387005.A0A183HJK1"/>
    <dbReference type="WBParaSite" id="OFLC_0000766201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000766201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000766201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000766201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7724" checksum="CC02E621707FD0CA" modified="2016-09-07" version="1">MLLHEHNAIINSLACNEDGVLVSGEAGIFALTFDQSGSRLITAEADKTIKMYKENENPTKETHHSCAEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJX3</accession>
    <name>A0A183HJX3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS7786</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01008352">
        <property type="protein sequence ID" value="VDO52499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJX3"/>
    <dbReference type="STRING" id="387005.A0A183HJX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000778401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000778401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000778401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO52499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000778401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26616" checksum="C7068A156077A23A" modified="2016-09-07" version="1">CIDAFDHHCPWVHNCVGRRNYRYFFLFLFFLSLHMICVFSMALSYTVLNRADLLTRPNMCSMVLMALCVLLAVPVVGLTGFHIVLVVRGRTTNEQVTGKFRSGYNPFTIGCWGNVRRALCASQYPSFEVPTKRSRKAKKDYKDGKLSVVYVPEKNSFSKGGGLIRMRQMTEDDRSVGTTGISIGHSLHKDHSENGSKCNLFDEQDSKSLRRQSAMYHVSVIICFLLFYILSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJY3</accession>
    <name>A0A183HJY3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7795</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01008366">
        <property type="protein sequence ID" value="VDO52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJY3"/>
    <dbReference type="STRING" id="387005.A0A183HJY3"/>
    <dbReference type="WBParaSite" id="OFLC_0000779401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000779401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000779401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000779401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27129" checksum="CC31AA8F32FDCE9B" modified="2016-09-07" version="1">RWEFKHPTPFLRTREFLWQEGHTAFQTKQEAEKEVFIILDLYAKVYMDLLAIPVTKGRKSEKEKFAGGDFTTTVEVYVPINGRGIQGATSHHLGQNFSKMFDISFEDPETGKKTFAWQNSWGMTTRTIGAMIMIHSDNDGLVLPPKVAPIQVIIIPVGITAQMDKKIRQEIIAKTEEVMKILQNSNIRTDIDLRDNYSPGWKFNHWELKGVPIRLEIGPKDIEKSQVSSRDNKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJY7</accession>
    <name>A0A183HJY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008374">
        <property type="protein sequence ID" value="VDO52538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJY7"/>
    <dbReference type="WBParaSite" id="OFLC_0000779801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000779801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000779801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000779801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12882" checksum="7E54DDDBBD320BC9" modified="2016-09-07" version="1">MAQRPIYQNVSTLDDFICRMVNSSTISIRNEEEFEYVKFLYEITDITKSSYPLLIGLTYQDEHFHWHDNSTFNYDKFLGIGYKRRLSELKKGACRRFFLYSPPTCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK06</accession>
    <name>A0A183HK06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DOT1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7815</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008406">
        <property type="protein sequence ID" value="VDO52635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK06"/>
    <dbReference type="STRING" id="387005.A0A183HK06"/>
    <dbReference type="WBParaSite" id="OFLC_0000781701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000781701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000781701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO52635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000781701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14760" checksum="61A83CCCFB9E5869" modified="2016-09-07" version="1">MASWLPCSRTVLYLLHNLSINSRKYAGKIALRRESVDKRFLCTSSEGIIFDREAKRIQRNRAAQLDDYNVCQYVKDEIAYRVADKVFDLTKFNDICIDIGCGSGHIAMNLIKVILNLINRLIIFANSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK50</accession>
    <name>A0A183HK50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008491">
        <property type="protein sequence ID" value="VDO52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK50"/>
    <dbReference type="STRING" id="387005.A0A183HK50"/>
    <dbReference type="WBParaSite" id="OFLC_0000786101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000786101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000786101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053302">
        <property type="entry name" value="CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159:SF6">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159">
        <property type="entry name" value="PROTEIN CBG07705-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000786101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32851" checksum="03B67202B0568EF2" modified="2016-09-07" version="1">YNNPESTEDFYQRPLIRKCSRFITITKITRQWIKDLDNGIVFVEMPIENPQKFLKAVRVSEYLHAFFGFCEHFQNMVLENEKKTGRRSYAVCIFDQKGCSFLPYMNPFGAINKLMLYRIHLWLDYYSELLKRIFIVNAPAFLSPMQKVMAMLLPAKTLNRFIIAKNLPNDLLPYLAVESIPVAYGGKLSIPNTFDNTCVATEPITPFDYQKSGQIWIKNSVSAKSETLTVKGGCTYQKAFKVMCGQVLLYEYFANGDLQFWICQDDEILTPKFDHTTLELTEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK75</accession>
    <name>A0A183HK75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA_9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7886</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008536">
        <property type="protein sequence ID" value="VDO52988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK75"/>
    <dbReference type="STRING" id="387005.A0A183HK75"/>
    <dbReference type="WBParaSite" id="OFLC_0000788601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000788601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000788601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF352">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000788601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9574" checksum="E513217564DDAF73" modified="2016-09-07" version="1">MLGLAIQIETPTLETRLNELTGDVEQMKIKLDGIEQSLLQTLASSEGSLLDNTDLLDSLNKSKENAETIATSLIEADKLQKQLVKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL34</accession>
    <name>A0A183HL34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8196</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009078">
        <property type="protein sequence ID" value="VDO54489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL34"/>
    <dbReference type="STRING" id="387005.A0A183HL34"/>
    <dbReference type="WBParaSite" id="OFLC_0000819501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000819501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000819501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="3">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000819501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16483" checksum="15DCC284A1EE0D28" modified="2016-09-07" version="1">EEIKIEFNYFSFQIPRRPDKPGKGSYWAVHPHALGMFENGSCLRRRKRFKVQTYGANEDLQHSLPKLTYHQPPCSSLQWLFPTTHLPSTVTSGTFMDPQQFFLTTHSLLLFPSLTQPTTDLSSIITPKSICNSSFTIDSILSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMM1</accession>
    <name>A0A183HMM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8733</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010109">
        <property type="protein sequence ID" value="VDO57121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000873201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000873201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000873201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552574" evidence="1">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000873201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19008" checksum="99AED6C18983D2C5" modified="2016-09-07" version="1">MGSCSSWLSCNLFSLLITLLVFLPIISAVKCFSNTQKFQTEEECGPNGYCFSFNGSDQLSYSKTLRGCDNSFICEIMISNITQDKKYPVGKRIKNIFGFTNYCASNVNIHPIQEKYYLNGKLCCCNEDWCNVNYANEPINDLSRILDLDSGTATDYAILKNIASKYGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP44</accession>
    <name>A0A183HP44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011169">
        <property type="protein sequence ID" value="VDO59415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP44"/>
    <dbReference type="STRING" id="387005.A0A183HP44"/>
    <dbReference type="WBParaSite" id="OFLC_0000925501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000925501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000925501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000925501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13330" checksum="6E64FC8296D754B9" modified="2016-09-07" version="1">MVESMNKNFRPSIGSLPISIEQKGTSIIIHWDQTRKTTNFTSQDPENQAVLIRYARSDTSSLREKAEEGLFINGAMNLTGKFDAVNIKFFFVIGYKFYYLIIRNLFCLEEFKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP84</accession>
    <name>A0A183HP84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9300</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011262">
        <property type="protein sequence ID" value="VDO59608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP84"/>
    <dbReference type="STRING" id="387005.A0A183HP84"/>
    <dbReference type="WBParaSite" id="OFLC_0000929501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000929501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000929501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000929501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16233" checksum="98268BA5B58A6F94" modified="2016-09-07" version="1">MALHVPVENFWRSNFAVIYIRDVDSLAPMEVYVDDEAKLTLHGLQQHYVKLKESEKNKKLLELLDQLEFNQVVIFVRSVQRCGALHTLLSEQNFPSIAIHRGMPQEERLSRYQQFKDFQVLWSILYQVLPIFNRLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPB1</accession>
    <name>A0A183HPB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9324</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011311">
        <property type="protein sequence ID" value="VDO59718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPB1"/>
    <dbReference type="STRING" id="387005.A0A183HPB1"/>
    <dbReference type="WBParaSite" id="OFLC_0000932201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12660" checksum="0AAA37F9AD843799" modified="2016-09-07" version="1">MGFRPSWRHHNGKRTDCDVGDECLSRVPYASIIATSMCGIGVILFTLVMTWAFNASVEQARRMLNTDNLPWLDKMQVLFICVAALMSITALILLIIAAMSTGSTRKELYSLCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ39</accession>
    <name>A0A183HQ39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malic_M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9601</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011947">
        <property type="protein sequence ID" value="VDO61813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ39"/>
    <dbReference type="STRING" id="387005.A0A183HQ39"/>
    <dbReference type="WBParaSite" id="OFLC_0000960001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000960001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000960001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000960001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14557" checksum="B3448043A1DA8DDE" modified="2016-09-07" version="1">MAMINERPIIFALSNPTDNSECTAEEAFTYTNGKVLFASGSPFPDFRLNNKLYKPGQGNNSYVFPGIALGVILFQVRHIDDELFLIAARVIADMVTTKDIEVGRIYPNLKIIRECSIQIALAVAKHCYASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQJ3</accession>
    <name>A0A183HQJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS9762</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012319">
        <property type="protein sequence ID" value="VDO63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQJ3"/>
    <dbReference type="STRING" id="387005.A0A183HQJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000975401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000975401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000975401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000975401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13655" checksum="7D12ADEE9545A895" modified="2016-09-07" version="1">MILRFLNRNDDAKPTIALEYSYGRRNRGKVKDVGHIWELGGGTNLCDLLQIPLASNYIQQCSLMIVIDLTAPFDMWNTFYTLLDSARTIVDSAMQQFSKTLPDSYEAFMIDRKAAFKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQP3</accession>
    <name>A0A183HQP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012449">
        <property type="protein sequence ID" value="VDO63524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQP3"/>
    <dbReference type="STRING" id="387005.A0A183HQP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000980401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000980401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000980401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUP210 Ig-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000980401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18189" checksum="0744D7E8BF755D68" modified="2016-09-07" version="1">MLEKPLTVFPLGYRLHVDVESRDHFGRLFDAAKHSLNYRPHRFDLTEIHPGNANSSFDIHLKDFGETVWDRNNPELNVFLRLPVGDVIRPLAHSVVLSEIVCFNSPLPVSGWKELDGKRHFQFIDEKSGIAVAVDTGNTVIASYDAQKQTIFTKVYSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQU4</accession>
    <name>A0A183HQU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9853</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012540">
        <property type="protein sequence ID" value="VDO63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQU4"/>
    <dbReference type="STRING" id="387005.A0A183HQU4"/>
    <dbReference type="WBParaSite" id="OFLC_0000985501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000985501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000985501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000985501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11566" checksum="59970EFC5ACAF9E2" modified="2016-09-07" version="1">MRRQRLLDALTNPMQRLTRYSLLLKAVLKYTVDDIERDIIQDMIVRIEKATRNVEDTLSNNDLINKLNELSRTIEGYEFVDCEEFEKVRKSFFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR51</accession>
    <name>A0A183HR51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RED_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9961</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012778">
        <property type="protein sequence ID" value="VDO64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR51"/>
    <dbReference type="STRING" id="387005.A0A183HR51"/>
    <dbReference type="WBParaSite" id="OFLC_0000996201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000996201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000996201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000996201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10343" checksum="18C1BC357168E36B" modified="2016-09-07" version="1">MLHETRRDEKRRLQGRKKSDGEYHEPCERSEFYHMSDLTKRAALFIGPDEYDSRYLESSLAFDPLSELEPVAKRPRTSERSKEPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR90</accession>
    <name>A0A183HR90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9997</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012861">
        <property type="protein sequence ID" value="VDO65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR90"/>
    <dbReference type="STRING" id="387005.A0A183HR90"/>
    <dbReference type="WBParaSite" id="OFLC_0001000101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001000101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001000101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001000101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12340" checksum="343879E82D9A9FCB" modified="2016-09-07" version="1">MRKQVVLRRSAPSERLGLGIAIESDDTDNKVISVRVEQVDSYSIASRSGLQVGDRVWSVGGTDVHQCTRIQCLSLLQQPTMTVAMIITRQNTFVFTKTSFFFLESIGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRG4</accession>
    <name>A0A183HRG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013056">
        <property type="protein sequence ID" value="VDO65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRG4"/>
    <dbReference type="STRING" id="387005.A0A183HRG4"/>
    <dbReference type="WBParaSite" id="OFLC_0001007501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001007501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001007501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001007501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21047" checksum="49C2F5AF083938B9" modified="2016-09-07" version="1">MEEDFDVNECHNPIVENVFDSQEHHSLIGVANVFLEVLLHNMRLDYQVPIISQQGEVSGRLHVEVYRLSEMDDSGIVSSLDSLDSNRTIDPQSIGATFLGKTIKCRVRIKKALNLPSSLSHFVFCQYSFFNTSEILVVAPTFDPNTNRSNRADIPWNSNFQFDHEKVIGLFFYKQLLKLNNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRI6</accession>
    <name>A0A183HRI6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS10094</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013105">
        <property type="protein sequence ID" value="VDO65778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRI6"/>
    <dbReference type="STRING" id="387005.A0A183HRI6"/>
    <dbReference type="WBParaSite" id="OFLC_0001009701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001009701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001009701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="8">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO65778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001009701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13936" checksum="D147F2E3FFD40DCE" modified="2016-09-07" version="1">MDGVIMGGAADLLFEELEKNEEIYSLMIAGLCKYSNAECITRALELYKEMREKDFVPTVEAYCGLLTIAKTWQEAMFYLKDMAQKYIKPNIRVFNILIEKSISMVNFNLYLFYVYEFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRS2</accession>
    <name>A0A183HRS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein amnionless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10184</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013308">
        <property type="protein sequence ID" value="VDO66504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRS2"/>
    <dbReference type="STRING" id="387005.A0A183HRS2"/>
    <dbReference type="WBParaSite" id="OFLC_0001018301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001018301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001018301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552610" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001018301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13554" checksum="EB374C32EA1D8967" modified="2016-09-07" version="1">MRGILQILLLLLLQMLNVQSLTYMFRRTNILKRAEYWENNTGPCENDHVYFDKTNITTALIADGLDSQQIVLPNNGILFFGEKMELGKLGDWQCKKKQNEESEIFCHKILLFKTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS84</accession>
    <name>A0A183HS84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013691">
        <property type="protein sequence ID" value="VDO67753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS84"/>
    <dbReference type="WBParaSite" id="OFLC_0001034501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001034501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001034501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001034501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17172" checksum="48DD932250E679BA" modified="2016-09-07" version="1">MHYIAFRTINFIGSQQWPEMRTVWRLFLDHCKVFTQPSPLAIVFRLQLMKDEECSPQITSVPDAYNSTLFSNGNYRLFEGNPLLVSLIEAFDINSRWYGGRAMLTIEMSFAASNFQIQMNKTLPIQSLLKDGDFRKKLKDIYEHIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSD4</accession>
    <name>A0A183HSD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10403</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013829">
        <property type="protein sequence ID" value="VDO68201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSD4"/>
    <dbReference type="STRING" id="387005.A0A183HSD4"/>
    <dbReference type="WBParaSite" id="OFLC_0001039501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001039501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001039501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001039501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7532" checksum="49767B14B77C50B0" modified="2016-09-07" version="1">MHSRMSRLRRSLSRGSLFNGLSKSQLSLVDLPTLHQQSMLRNQDVKMASVFQSMHDNELFAGLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTH5</accession>
    <name>A0A183HTH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2513 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10786</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014798">
        <property type="protein sequence ID" value="VDO71325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTH5"/>
    <dbReference type="STRING" id="387005.A0A183HTH5"/>
    <dbReference type="WBParaSite" id="OFLC_0001078701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001078701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001078701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001078701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10653" checksum="CF76CC2B79F53856" modified="2016-09-07" version="1">MSHFGFDDKSHMLDADPTLMKKCSQELDRLGCRQEKYFEDVVECLRLKYDELGLECKAVVFAREKIEAVDNQFDDELQVTFISFGIDYCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU00</accession>
    <name>A0A183HU00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015231">
        <property type="protein sequence ID" value="VDO72690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU00"/>
    <dbReference type="STRING" id="387005.A0A183HU00"/>
    <dbReference type="WBParaSite" id="OFLC_0001096201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001096201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001096201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001096201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13206" checksum="ACAC81E00D7C6F18" modified="2016-09-07" version="1">MGFYIHSCQKMCYKKRFRPSDLLCDRSFTWVPLDRCLEMMEKHGERIEAFAPDAPIAEKCPLVSIKCLYKMNVLPYRILLTLPDFKETETFMEEYARIVGPVAREMLLYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUC2</accession>
    <name>A0A183HUC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11084</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015550">
        <property type="protein sequence ID" value="VDO73689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUC2"/>
    <dbReference type="WBParaSite" id="OFLC_0001108401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001108401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001108401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001108401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7891" checksum="95D5A4656EE6FCB2" modified="2016-09-07" version="1">MANAGIVYIWMMPEVSVIRPLINHSALRFISEPTTAHAGLVMLESVVIYQLINAVVISAPRKRLFIVYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV47</accession>
    <name>A0A183HV47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like_fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11355</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016321">
        <property type="protein sequence ID" value="VDO75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV47"/>
    <dbReference type="STRING" id="387005.A0A183HV47"/>
    <dbReference type="WBParaSite" id="OFLC_0001135901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001135901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001135901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="80"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001135901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18188" checksum="5D1880D6E0576D1D" modified="2016-09-07" version="1">RALHYCSTPSLIVLDASSRQIITDDGRRLLQDDPNGLNFPWCNATAEELFQGAVLRNCKEVDGTKKIVVENFQNLKPTVKGLYFGANWCPPCRSFSQQLISCYGSLKNIGIPFEIFFCSSDRSQESFEHHFSTMPWLAFPYDPQKTTQLARLYGVNGKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWQ3</accession>
    <name>A0A183HWQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11913</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017830">
        <property type="protein sequence ID" value="VDO80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001191501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001191501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001191501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001191501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8154" checksum="B2D9B3100E3F06AC" modified="2016-09-07" version="1">MIVDLRDGVVLLNPLLELSLFPPPVIAVPGFIVSLLPIIPSDSSVRSNDAGEFDVPLLLPPPLPDFFWCFLEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWV1</accession>
    <name>A0A183HWV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAWADEE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11963</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017938">
        <property type="protein sequence ID" value="VDO80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWV1"/>
    <dbReference type="STRING" id="387005.A0A183HWV1"/>
    <dbReference type="WBParaSite" id="OFLC_0001196301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001196301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001196301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001196301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16856" checksum="1E842F11B74F144F" modified="2016-09-07" version="1">MEQEFINIGWFVATEYTDPELQEEPPASPIIEKLQRRVCTDDVRVTTFAIKWRRNEENVIDSGDSGDIDSSEDIEINETIKRNGDDFAIKDDIDADKNDDLEQSLEANRNVDVKIEDELEIEASLEGKSTITGLPLLDVTNESIPDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYP5</accession>
    <name>A0A183HYP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12607</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039881">
        <property type="protein sequence ID" value="VDP11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYP5"/>
    <dbReference type="STRING" id="387005.A0A183HYP5"/>
    <dbReference type="WBParaSite" id="OFLC_0001260801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001260801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001260801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF49">
        <property type="entry name" value="PAIRED BOX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001260801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11884" checksum="4364BE4BF2571D29" modified="2016-09-07" version="1">MCIGGNPRSRLAIQAVEKHILALKAKCPSLCASELRSCLIEQEICSPENAPTVSSINRHIRARKLNNSFNGKERKATKKNQLNHSIEHILGLHAGNIENTVSYLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYV8</accession>
    <name>A0A183HYV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gnk2-homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039899">
        <property type="protein sequence ID" value="VDP11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYV8"/>
    <dbReference type="WBParaSite" id="OFLC_0001267101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001267101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001267101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001267101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41192" checksum="FEF1AE3D52A62EB9" modified="2016-09-07" version="1">MTCCQSIRLPTFAGNIPNVIGERKPLPSYPPACPPVRLLTCSAYHISPILLLFYAEVNPVLWIGTYVSGIEGIPRQVSNRSDLSLCGRNAGAEEWLLVVRDGKDNNCASTTITFAIAIFSSSSLHCLNPTGSAGSDQLSTKDYELARQCGTVPRCLERDVPRILSLFLSPSHPSPHNPVFLVRITYILLVDISVRIRKVLFAPKPCDFTVLGDTAANAYNNSSRCRRCLVVSVVNEAKNHDRILRPHISSVMYYCDKYYNFSSHCRAFSSRFRSCLAKYYFLNLALNAITATVDCGLMRGVKSFLKKGLLNDELSDSSKGHSCLHMSASAHHFHLLSLEKLTLLYQIFFHRKESTPISLNRPIVVVSWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZG1</accession>
    <name>A0A183HZG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12873</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039960">
        <property type="protein sequence ID" value="VDP12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZG1"/>
    <dbReference type="STRING" id="387005.A0A183HZG1"/>
    <dbReference type="WBParaSite" id="OFLC_0001287401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001287401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001287401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="107"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001287401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="793" mass="86860" checksum="F8FC249C6BA568BB" modified="2016-09-07" version="1">MTDKKSVNPVQNGAWFTEGTQGDVGRDLLPVVDNTNQSSSKLLCGAEENSKRNGHVNPDDTKVHNDENMSDKYNHDNAVIQDCHSDKVGLEEGNSNDVLPIPPDGGYGWVIVFAAFMSNFVVDGIANSFGAFMSIYQDYFNASKALVSLIGSLLIGCYLLIGPVVGGLVNKYGARMVVIIGSFVAGLSFIASLFCSNIYMFMIFYGFLGGAGFGLIYLPSIVTVGYYFEKKRSIATGLAVAGSGVGTFVLPPLCIVLINHFGWRIAICSLAALSFSSIIYGLLYRPLQAPAIRKKERNTKADVEELVSRKMFTDSAASENKLQKFIRTRNTQSECEMHEFDEMTPLAPSDGNMTGKNRGTLSNSSEGLSTSSRRDPTTSMKSKAASIDLKTSRGNLAEVLSKISVHSFGHSTSFRSRSSQMKDAQSLASVTSSTGPKEFNKPLNRRDIFYSGSIRNLSEFKSEGGNYRSYRESQVSIPTSAVVQAIADLSQVEGTSDTHDKFERNRGTIGEQGEQLDELIDCYVDRRCKWIPVTIRNILSEMIDISLLKEPAMFLLCISNLFGMLGFYVPFMFLIDMAVAKGHSKGSGSLLLSVIGVTNTIGRIAFGWLADRGWLSALTINNFALIGCGLLTCLCPLLPGYGGLMVYSVLFGFIISAYISLTSIVLVDELGLERLTNSFGLLVVSRGIASLLGTPLAGIVYDVFASYDASFYFAGVIILLSGLVSCLIPAVRRCRLNESAKETVEETRMINEDIQFEKLPVLTEHTEENLTEYQRTVQSLRQQQKFLERRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0E5</accession>
    <name>A0A183I0E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13207</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040088">
        <property type="protein sequence ID" value="VDP13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0E5"/>
    <dbReference type="WBParaSite" id="OFLC_0001320801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001320801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001320801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001320801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13075" checksum="BB42F0C42A8A51EC" modified="2016-09-07" version="1">MARQDLRTKRMNDMRVNQYYTSMTKGKDISNTMQSFTRNDKTDDDKKICGWQTMPRGVCCNTYHLSRVPTNVDKTCFKDPCVQHRTFRSYPPAQCFTTRYAILRSLCNVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0J7</accession>
    <name>A0A183I0J7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GST_C_6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13259</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040113">
        <property type="protein sequence ID" value="VDP13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0J7"/>
    <dbReference type="STRING" id="387005.A0A183I0J7"/>
    <dbReference type="WBParaSite" id="OFLC_0001326001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001326001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001326001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF32">
        <property type="entry name" value="GST_C_6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001326001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19692" checksum="F04FD141639FA489" modified="2016-09-07" version="1">MSTSATKMARRFPAILSQSGSENGISKIHNKRWKKDVVYLYQFNRASSSPNISPFCFKVETWLRANELKHEVNRIFIDMGITKCSRNDLIGMLLKDIAAIDIILGDKKFLFGVKPTMSDFTVFGHLATSYYLPFRQPITDILDDKYPRVKRLIERMRRHYYPEWEFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0M4</accession>
    <name>A0A183I0M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13286</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040126">
        <property type="protein sequence ID" value="VDP13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0M4"/>
    <dbReference type="STRING" id="387005.A0A183I0M4"/>
    <dbReference type="WBParaSite" id="OFLC_0001328701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001328701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001328701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001328701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8540" checksum="014CD9B04B7AEAE5" modified="2016-09-07" version="1">MEEHMKRTSWPALDNDDIYEHQRKRFEQYFSLNGFCRRINDALAVLFPDDPIIASNTLLLENEDKNFFKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0W6</accession>
    <name>A0A183I0W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13378</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040170">
        <property type="protein sequence ID" value="VDP13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0W6"/>
    <dbReference type="STRING" id="387005.A0A183I0W6"/>
    <dbReference type="WBParaSite" id="OFLC_0001337901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001337901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001337901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001337901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34963" checksum="DE149FCE8D47FCDF" modified="2016-09-07" version="1">MERYATSERKKELFAEVAGALNASGLVTAGLYTEEDVRTQWKNLKDTFKRKLKRRQAEASAGYEDVEPTWRFWSKMQFVKNNFGPDRNRSSALNSTILVENTPNTLEKLISSLVEKQMSDDSNNSIDGQILNVTELPSVASTSLPIPSANSNNNSSCNKSTLNNINTFIPDIQVTSTATPAIEMHIAQFVPPNINYLEGIASHSPLSQHLGFDSNKLRSPSPVNPEIHPCASVLADLQKKAMKRKASEAGNEDLQNIQEPDDECAWFGRSVSSALRRLCLTSPLSALTLKKQISDLIYEAEIKQLVRHRRTEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1L3</accession>
    <name>A0A183I1L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13625</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040301">
        <property type="protein sequence ID" value="VDP14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1L3"/>
    <dbReference type="STRING" id="387005.A0A183I1L3"/>
    <dbReference type="WBParaSite" id="OFLC_0001362601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001362601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001362601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001362601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37195" checksum="EF2A8DF2274ACBCA" modified="2016-09-07" version="1">MEKDFGMNKPVRVALHPSLANRLAIGFIDGSIRFCDFDLSKTEFQILASRKLKRAVRELSFSNDGEQLFAACENRALCVYNVEANKRTRCIQKSHDHKINALFVLPDASVKHQQIVTGDEFGEIKSWDLRAKEPVVSCFNEQEDTINDFGIAGNTLLATSSDGTLGAYDFRRQKLLIRSEPMHSELLCLVVSQKYCYIGSGDGHVEVFKTREYGNLLERIKIDHPLGIDCMQLLRHGVLLTGANEDDQLRITHLGPNKNMGNIGLHIGGVQQLSITCDRECLISVGWLESTVKFWCLPKLLNKIPILQSNDISSKKLPKSANFFDDLVNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1R3</accession>
    <name>A0A183I1R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamic acid-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040328">
        <property type="protein sequence ID" value="VDP14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1R3"/>
    <dbReference type="STRING" id="387005.A0A183I1R3"/>
    <dbReference type="WBParaSite" id="OFLC_0001367601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001367601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001367601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001367601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48570" checksum="FAE7F4ACD200A437" modified="2016-09-07" version="1">MSKASLYESSLSSATPKALFFRCFEKDASCVARVGKTIVGADVVEEGLLVAESDGFRSFVRLLLSSTITNISFSLEKSLVHAAGQYSRRQQHNSFVEFDGDENFDFDGDIDDDADEMAIHNRRAEKDTTPSREYISRSKTVEENRKAHQAIQDVPDSSILNCIYVNVVEQADLPSRTKGRHMEEEDKTSRKQNKEKDKPKRAKGHRKRIKVMEDDEEEEERTMAQKVELEKEEEQEETDGRNVQIEDSIEHEEKKSAVVNEGKESEHEYDTEKPKLKSRRKIPSFNMEKSKRECKRKNCLPEYDHHPRMSLLKEVPFSVKNRNKQQSIAGSKSIENDEKEEEITDTDDEWENEGIENKELDDESIRDLAAIKKEKSNDRTIYKRHAITNRDDHKYRNQLDRADYLVEKVSKKDKRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1X6</accession>
    <name>A0A183I1X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040367">
        <property type="protein sequence ID" value="VDP14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1X6"/>
    <dbReference type="WBParaSite" id="OFLC_0001373901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001373901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001373901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001373901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55468" checksum="66197CB917986DEB" modified="2016-09-07" version="1">MIDNKFSAAATPADAHDEDEIFEGVDAEINPIIDEKNEEFCFSRKVHNIEACSIAFCVTENRSVQMGNILTQNCKRSQILQFSCPVIFRLFTMKERPSLTSVSLTTDFLAFANGLSRQKSPIKAKKIPQSSSTSSKSDSTSKSKISSPEISQGIVSTVAVKKRESRSKDSVSISSSESKTDKIKRIESGSKTVKDKAKQDMNERKKKDKVKKKKKKTEEKSVERKEFKTSQKKMEVIKDHKKKENIKDVKKSKGKGYEIEKSKEKKLENGKVLHAKTVREELVLQSCGIESKKATETSGKYELKSETLSNKPLIETASSLANIPLEQSPQSISNIDLLPIEMMKKDQLLYEKMEDDIVLDTNVLQSLATDLTTQSNKVNKDVIGEDIAKKLIEIEKKDQSSTEQDHIKEEKEIVISEIARKIVEALTSNHVLGKVLTPEEAAILKDYFSQKIPLSEKDSELSFWGSFPMPDLHLSPFDWVASFCLTMDWRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2D1</accession>
    <name>A0A183I2D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13893</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040453">
        <property type="protein sequence ID" value="VDP14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2D1"/>
    <dbReference type="WBParaSite" id="OFLC_0001389401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001389401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001389401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552735" evidence="2">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001389401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20696" checksum="1A471B02D4AC7759" modified="2016-09-07" version="1">MLAIIFACLLPSITGQYSSLTNSAVDETSETSYGERESSDNYAKPTVPVAPPRIPIRDGPSLGYRPPPPPIRRDAKSSGKCNFDQNSWRFEPQTAIANAIMFDRTTGSTCEECVKNCLQFQDPNSEWVCRSLTFDHQWKICDLFAVNGTNPPHFLTEYMDRDYLECIYLFFLLLIISFQNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I367</accession>
    <name>A0A183I367_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14178</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040646">
        <property type="protein sequence ID" value="VDP15791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I367"/>
    <dbReference type="STRING" id="387005.A0A183I367"/>
    <dbReference type="WBParaSite" id="OFLC_0001418701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001418701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001418701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000100">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000238">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP15791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001418701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15199" checksum="B99A2997FE9C13EC" modified="2016-09-07" version="1">MFDKDRNGTISTKELGIAMRSLGQNPTEQEIMEMINEVDIDGNGQIEFAEFCIMMKRMMKETDSEMIREAFRVFDKDGNGVITAQEFRYFMVHMGMQFSEDEVDEMIREVDVDGDGDIDYEEFVKMMSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3A1</accession>
    <name>A0A183I3A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ subfamily A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14212</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040677">
        <property type="protein sequence ID" value="VDP15985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3A1"/>
    <dbReference type="STRING" id="387005.A0A183I3A1"/>
    <dbReference type="WBParaSite" id="OFLC_0001422101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001422101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001422101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000014">
        <property type="entry name" value="dnaJ homolog subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP15985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001422101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43226" checksum="3DB756954AD2093A" modified="2016-09-07" version="1">MVKETKYYDILGVAPNATENELKKAYRKLALKYHPDKNPNEGERFKAISQAYEVLSDPKKRQLYDEGGEEGLSGAGGGGNFHNPMDIFDMFFGGHFRGGERGERKVRDMIHQLPVTLEQLYNGAVKKLKLSRNIVCPKCGGIGGTKGSVISCETCKGRGVRIEITQIGPGMVQQMQSTCNVCRGEGEVIPSKDRCKQCDGKKKIRNESVLEVHIDKGMKDGQKIVFSGQGDQEIGITPGDVVIILDEQPHDTFVRKGHNLVMQVDLELVEALCGFTKSVPTLDSRYLIFSTVPGEVIRHGDMRTIVGEGMPHYKNPFEKGDLLIQFAVRFPKKISQIDQLKNLLPGGTEPLVSDDAEIVELEIIHDHGPRASSSYEYETHGPQGVRCQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4G6</accession>
    <name>A0A183I4G6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4477 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14628</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041018">
        <property type="protein sequence ID" value="VDP17944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4G6"/>
    <dbReference type="WBParaSite" id="OFLC_0001463901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001463901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001463901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001463901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24126" checksum="C2898E505E50D30B" modified="2016-09-07" version="1">MELFESLEEEALLSVVDKYCSQPVHNPFEADNKKFDATVINEKLVIDKLIDLYPNSVAPQSVAILDALIYKMSAPYRHAKFWRFTRRVSKELNKLNALKLNKYLKNIAKDMLKSEMHYSLNVCAKRYIVSVLICRAIRSYRLRKLCEQAALHCLQHIQTGHLLQSNLLLLALNADVYDAVKKNMAKIMECYNCLQSFFADSRYKLLCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I532</accession>
    <name>A0A183I532_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14846</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041275">
        <property type="protein sequence ID" value="VDP19188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I532"/>
    <dbReference type="STRING" id="387005.A0A183I532"/>
    <dbReference type="WBParaSite" id="OFLC_0001485501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001485501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001485501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional adapter 2-alpha/beta-like" evidence="2">
        <location>
            <begin position="279"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP19188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001485501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51654" checksum="0746C78A050DBABB" modified="2016-09-07" version="1">MESNYMFVSILLFSRPYVNYHRNEEMSLPHSDSDAIGQGHEVDSSNWQYIAEFFRDWNQSVNLDDPNWFDQFKEPLMKFKNEFYASQLRSSAKKSDKQQNFESSDGPPLITPPLSPFSVEFFRADNEGKRKRLLSVSDFDESDDDGTTNSESSNSYDYKTELSTLCSKKSGSRSVHIYRNSSDALPSTDEGSEPEPEQKYEKKKPVLQLKRVGRKRRKNESREKLFLKEAYKGKLMIKINEDVKKRLREFYPEQFYANVPLLPFGAEERSKLKDTDLQLLGYMPEREDFEWEFMNDAEKLISRLMLQPEPDTDEDSAFESGEFFIIAVKIAKVQKYNRILKQRRAKKATVREYELVNKFFDKIKKIDETRRSLIHNQQYSASVRQCELLHSFMKKTYQVVRQSELKQLLDAITGYINLNERILSLENIKLDGIKNLKGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5V5</accession>
    <name>A0A183I5V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 256 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15117</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041637">
        <property type="protein sequence ID" value="VDP20473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5V5"/>
    <dbReference type="STRING" id="387005.A0A183I5V5"/>
    <dbReference type="WBParaSite" id="OFLC_0001512801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001512801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001512801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001512801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16552" checksum="85021E235B059C5C" modified="2016-09-07" version="1">MMDYLISFMDSVCPPKNSRTTMSSKPTNMPLNFLKETHLVRVAGFSGALAISLGAYGAHVLRESGNADERRIRSFETGNRYHLIHSATLFFANKARFPWLTVSLLLSGMIVFSGTLYHYSLTGKDNLRKYTPYGGVMYILAWLSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6P1</accession>
    <name>A0A183I6P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15403</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042074">
        <property type="protein sequence ID" value="VDP21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6P1"/>
    <dbReference type="STRING" id="387005.A0A183I6P1"/>
    <dbReference type="WBParaSite" id="OFLC_0001541401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001541401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001541401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001541401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16150" checksum="0B4FFEF05E755710" modified="2016-09-07" version="1">MRLLFSFRLLLRDNFPTSTTRFSFSAAVQKEGSNEASNFSLKHENARLTSAEFLTKIKESIGAAETGEDFVIPRPAFDALAAEYDALLEEVATFKDKYTRALAEVENVRRRGQRQTEEAKVFAIQGFCKDLLEVRFFFPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6T8</accession>
    <name>A0A183I6T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15450</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042164">
        <property type="protein sequence ID" value="VDP21929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6T8"/>
    <dbReference type="STRING" id="387005.A0A183I6T8"/>
    <dbReference type="WBParaSite" id="OFLC_0001546101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001546101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001546101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP21929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001546101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20632" checksum="A9D03FCD2E759797" modified="2016-09-07" version="1">MSKTLDYGANSNNGNNEKHVRSHQSVTQQPRWFSGLRARISQLNMPEWLSQLGVRNFNYIASTEEVLPDDEAEKKVNCKDDQSKRRLDDVSKKLETCTDPEGDTIGSWLWEEADYEDTLALQHFGPLKNLITGCNHPGKGHDFLSLSVTHPTWCDKCGDFMWGFLTRAVKCDSKLMLLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V3</accession>
    <name>A0A183I6V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15465</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042188">
        <property type="protein sequence ID" value="VDP22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V3"/>
    <dbReference type="STRING" id="387005.A0A183I6V3"/>
    <dbReference type="WBParaSite" id="OFLC_0001547601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001547601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001547601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552797" evidence="2">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001547601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17336" checksum="1CAC86A333C8B843" modified="2016-09-07" version="1">MFELLRLISIFFFFSEVSKQTKNLKFSESKAYFGMDKRELLNETVMVASQSCLEAFDAATHRKKVIASFLSSFIAVCFYFWYSRKDYDGFLNAPKYEVVPTLKRYALRQQIERALKDGKDTTYLKAALEYVDVEEAVYRAEEGAFTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Z7</accession>
    <name>A0A183I6Z7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15509</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042275">
        <property type="protein sequence ID" value="VDP22266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Z7"/>
    <dbReference type="STRING" id="387005.A0A183I6Z7"/>
    <dbReference type="WBParaSite" id="OFLC_0001552001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001552001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001552001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001552001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14595" checksum="2B6A9B139A09E9F7" modified="2016-09-07" version="1">MNGEKIENGNKDDPLDISSINFNSEAYLSNLFRKKNLDELVQVEEDMINNVRRLDSEMQQLVYENYNKFLTATSTVKKMQSDFMEMGQKMESLSKRMSKIATLSKDLSSAFSKHRANVSQLSDANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I783</accession>
    <name>A0A183I783_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15595</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042425">
        <property type="protein sequence ID" value="VDP22754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I783"/>
    <dbReference type="WBParaSite" id="OFLC_0001560801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001560801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001560801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001560801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8714" checksum="69E4F1366AD4C5E2" modified="2016-09-07" version="1">MNRNNRRSSLAGSQYSASSRRSSCSLKDMERIQIAEAQVILIXXXXXXXXXRRSSCSLKDMERIQIAEAQVILININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7V9</accession>
    <name>A0A183I7V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulose synthase (UDP-forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042964">
        <property type="protein sequence ID" value="VDP24103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7V9"/>
    <dbReference type="STRING" id="387005.A0A183I7V9"/>
    <dbReference type="WBParaSite" id="OFLC_0001583401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001583401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001583401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001583401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12220" checksum="F8D128CE3F691B12" modified="2016-09-07" version="1">MRIFGIVPELCKYRLMKVGFWGDQLYVSPCCNDRIQIWSIHSFIPNSWSKLFDFPLIQLFYSFYTVSPDEPYIYALVVALFVSLICRIFGLWNSEKKTENGSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7Z6</accession>
    <name>A0A183I7Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043070">
        <property type="protein sequence ID" value="VDP24334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7Z6"/>
    <dbReference type="WBParaSite" id="OFLC_0001587101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001587101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001587101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001587101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12667" checksum="24AEDF7099FB8860" modified="2016-09-07" version="1">MGPAPLPTPTPIDPRFVKKSGIPPLASYSFLISSHPMEEVIPPVFPSDWLGEVGGVSITGACGRYAPSGKHHCFQLLSVCSSAARDRSDCRNHVKGVLTHLKALLSCEGGGREGRGRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8H4</accession>
    <name>A0A183I8H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS16036</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043712">
        <property type="protein sequence ID" value="VDP26302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8H4"/>
    <dbReference type="STRING" id="387005.A0A183I8H4"/>
    <dbReference type="WBParaSite" id="OFLC_0001604901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001604901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001604901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP26302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001604901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13849" checksum="F7F602CC90314B17" modified="2016-09-07" version="1">AKFQYECGNYSAASLCLDYYRNIVPQQNPNYLSALYGKLASEILLQEWTHAKDDLTKLRTYIDFNPFDTELESVQQRAWLMHWALFVYFNYPKGRDEIVEMYLNQQPYLNTIQVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V443</accession>
    <name>A0A3P7V443_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000302">
        <property type="protein sequence ID" value="VDO27043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZX0"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="417" mass="48351" checksum="13EEEF3312CF24BB" modified="2026-01-28" version="1">MTRWPLNKNLFFVRHIECFKANSSSSNVFGSISAIGESLKTVQQETTKTAVLMLHHGQPRTPYYATKHLAEGSHYYYKLPLWLTSRVTRLYWPLAKKVDFCVDNYKHSANFSNLISMYSKILQEYLNELVPEHGSFYCIHAFLYEEPTIPKVINDLIRRGMQRFILLPLYPHYSCFQTGTMLNIAVKVLDEQTIPLLKDGIGLMDHRVRTMSHVSFRCSTIDQWSNHPAVINFWCNLLYAELKNHDSLLFVAPQMRGYNSIGYKREVWTTCFLLMEHLNEVLPWKLAWFSGWDQWPATTLESIKLQLYFLRREKRYRTLIVPIASLIPSFESETLLPNILQNEGVDLLSPPGFSPVLAHGFAELIKNHLMGRRASSQLSCRCKFCFSSHCLLREAMLAPKEIPSNEIFLENTLGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VTL9</accession>
    <name>A0A3P7VTL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002847">
        <property type="protein sequence ID" value="VDO38447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="80" mass="9219" checksum="9CF883AEC3619390" modified="2026-01-28" version="1">MDGGELGKMEREGMVISSRRHHSVTECINEIQTPHEFEGMHTSSSYIPFINQRNLSVVRIKDHHAKINDWTVVISFFLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VUM3</accession>
    <name>A0A3P7VUM3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromodomain protein 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008106">
        <property type="protein sequence ID" value="VDO51971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VUM3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Bromodomain protein 4 C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO51971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="207" mass="23849" checksum="693A1E136C40420A" modified="2019-02-13" version="1">MSIIHFDYINGIWHYLIFVIIIRYLINYLEERGNGDSGASTGTGNQLVTVNSNNASSVVSQPQQAQSQISGGSILDQLLPAKQNEMEDKTGIKKLAGWDTLAKKSQSGSLNMQTSTQFELFRKHAREKEEKRKQLRVEEERRRRLKEQEEKERAKDQAAAETAELEQRRQNELLRQKEQERRRREAMSTGGDVTSQMDLMLNFEANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VVG2</accession>
    <name>A0A3P7VVG2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006216">
        <property type="protein sequence ID" value="VDO46769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VVG2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19868" checksum="228C1FD0FC686CDF" modified="2019-02-13" version="1">MSFFAANYITTIGVDFKIRTVTINGQRVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYEVTSGDSFSNVKRWLHEIDTNCENVQKVLVGNKADDPERRVVLEADARRFAETMKIPFFETSAKENINVEEMFNCITRLVLEAKLRAPQSNIADSGGGVRLGGSNIRRHEKRKCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XD36</accession>
    <name>A0A3P7XD36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000416">
        <property type="protein sequence ID" value="VDO27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0I9"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="514" mass="56487" checksum="965CC09C51C0EFD8" modified="2026-01-28" version="1">MKSHKYSLLALFIIVVDVFAKDVRKLCTNTVGSRSCGQCIKQHPECAWCLDPHMVGPSRCDLKSEFQGKCAPSLIYSPTTEIRTIPQNNLPLGSKQADGITVVQLDPQQIVLRMKPGDILEVPFKYLHRPQHLSQRDFVIQTSEFRSLGVGIDFSILCGGKRVQGRQCPNVAIGDQIEFFAKVSLNECKSGGDIAISIGAYGYQTVSAMYITPFCGCECEKVQNQERKSPLCYGAGDLICGVCECRHGKGGNHCECDLKQHGASSAQELENRCRKTPKDFICSGNGQCKCGSCVCNVEHVRGEFCECENMSCPTSQGRMCAGQGECKCGKCLCEEGYTGDDCSCSLDTIPCLEGGKICSGHGTCECGKCVCHEGFSGLTCGVMAENEAMEEEMPESTDFNQRGESKDSDEFSRDSISKAKYDQFQEDLDETTKNKGEEDEEYTEGVEGQEMNEDNDMKAGEILPPGEEASAELTKARDETGDEKIHEEQPDGSLRIEVHSFFPLIISLIILFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XGV9</accession>
    <name>A0A3P7XGV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015352">
        <property type="protein sequence ID" value="VDO73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XGV9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="66" mass="7460" checksum="97C76D4F8609EAC1" modified="2019-02-13" version="1">MNFVKFQGGPKPKELPQLLPTAELKTTPSGGTYRKIDYEVIDDSKLPRSEPQDSSSSQQNFEKYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z552</accession>
    <name>A0A3P7Z552_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006825">
        <property type="protein sequence ID" value="VDO48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z552"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="89"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="265" mass="30699" checksum="EC8CFBC269A5B90C" modified="2019-02-13" version="1">MWYRYQCPECPVTTVAHPAENTFTTQRLELSSLKAGSTYTVLIFAENKISKIEAAISQYALVEFTTRQLLDVKEVSLEIYCNYRATVPVVRGLRIEGVQESGVTIAWKPIEIIKNELSYEIESFHNNSSIVVETIRTYYTFESLKPQFMYSFRVRVVSEYGHGAWSEPLWYQPGRGLPIGPINDHDNDDDDYAQNNSIVDFHWSSSVPSLWIWVLLICAFVIIVLFTLLICLRQNQNRKRLSDCDGIDSYKNSIFICLFFFHFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZCD1</accession>
    <name>A0A3P7ZCD1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006585">
        <property type="protein sequence ID" value="VDO47752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZCD1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="136" mass="15075" checksum="3E1B36DCC0655BE0" modified="2019-02-13" version="1">MAFQELRDRIPGFTDDKKSDKGTINNTNSCASSALHNGKEHIEPSAALTDSHIEQLAPLLANNWSTLADVMNVNKERIDAKEEPMKVAQRILTAWRQKEGKAATVKRISSVLLMAELFSEQVGQVFRGNTPKRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZHL9</accession>
    <name>A0A3P7ZHL9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008236">
        <property type="protein sequence ID" value="VDO52288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZHL9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23102" checksum="6721CD5FFA442260" modified="2019-02-13" version="1">MRKAKPGGLPLNFRSAADSDTSSEEYSPCYLATPNCESTYELIQERLRSRIQQIDLSDLDDEDKAVKNGATDGCSSTPDSEFFQCKDISSIPSPFSVKKSITALLLEKTDFMIRSDLAAYARFAAPDIEKSRKLLVFYPFAKPESDNGKCFSLTIYAQCDIRISDLVGLCCYEYARCQRTNDIEYVFWLLLIYLKSISIHKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AG59</accession>
    <name>A0A3P8AG59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012400">
        <property type="protein sequence ID" value="VDO63358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AG59"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO63358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="220" mass="24873" checksum="FDA342999C823637" modified="2019-02-13" version="1">MITLSSIRSSFIQLHCFCKLYYSSDDLNSSNDTDNDEWLRGIGISPRKTLKITRNKSVMSNHSLDYERSLSLDPDFMDENRKSAIVLSDLDSIAAFYNMMTTSNFGRVATGPQAGFPPTLLARQPFLNAVLKNLKCQYREFTKDGTDFYVCEWDNGPIMPHMLSMLENFLRHSSKPNQENFITGQISGRFKCPGMNDAAGLGAMANFSSFEFRLGSFFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B7Y7</accession>
    <name>A0A3P8B7Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042269">
        <property type="protein sequence ID" value="VDP22242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="80" mass="8863" checksum="7967881D3F4B5ED8" modified="2026-01-28" version="1">MQAAQQSANSDHYILSHGLLEGSSNLHLIHPLIDLSMLRTNLAFIGQYQRNILGSFETSRHISDDAVKSFLIPPTITSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY86</accession>
    <name>A0A183GY86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS196</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000052">
        <property type="protein sequence ID" value="VDO24924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY86"/>
    <dbReference type="STRING" id="387005.A0A183GY86"/>
    <dbReference type="WBParaSite" id="OFLC_0000019501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000019501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000019501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000019501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35767" checksum="95F040E09BF03742" modified="2016-09-07" version="1">MFKVSSNKERKKLKKLKKDINEVLLLSGDDPTAVDLTSATFLGHSFDDKDISLKLYKKLRTMRRLKDPPKINFSLNRLNGIRLGSQNIADLVHYVSFHNVEKPLWISLRPNRGILQAVIFRVVCDLEMVESNKKETYIDQFFGSKSFIRMQTEVWNSMEFWTSMLNVPLSKFERLKRIISHAHILENHIKSNMKGALLVTMRQMVDFCYPFPKMNNVSVGIMTPIIPTKEKYGTIKVDSPFFAVDCEMCTTEIGESELTRISIVNECYEVLLDTLVKPRNRIVDYVTKYSGITEKMLENVNVRVEDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYC5</accession>
    <name>A0A183GYC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Pre-mRNA-splicing factor RBM22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS235</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000067">
        <property type="protein sequence ID" value="VDO25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYC5"/>
    <dbReference type="STRING" id="387005.A0A183GYC5"/>
    <dbReference type="WBParaSite" id="OFLC_0000023401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000023401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000023401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12224">
        <property type="entry name" value="RRM_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000476">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="216"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000023401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="537" mass="60878" checksum="313A622F4D06FF61" modified="2016-09-07" version="1">MALSKSSYQYNRKTWEDSLKDRHGAECKICQRPFTCFRWMPGKGMRYKKTEVCQTCAKMKNVCQTCLLDLEFGLPVQVRDHALQIQDDLPRQGANRDYYIQNQERELALTDGTTPGGALAKISDSASNDLLKKLARNQPYYQRNKPHICSFFVKGECRRGEECPYRHEKPSDPDDPLSHQNMRDRYYGNNDPVAEKLLTRAKALPVLQAPEDTSITTLYVGDLGPAGMIGEVDLRDYFYQFGEIRSLNLLPNKGCAFISFTTRLAAEKAAERSFNKLILQGRRLKIRWGRPQAQNTQEEKKRAEPVAGLPNPCPLPDLFDEETNPSNKRARIDHIPMPPLPPAATYTPPAQLIVPQVSYKGIVSYIPASATKVYYPSQDPQRLGAKDISDFVLLGWASTDFVLLGWARPFILMNRASSSSTAITATGHHSVEDDDGVVQMVMDPYCKPARQCFLCSKKIELDYKNARLLQQFVSTFSGRVYDQHITGLCDGQQKRLLETIALSRRAGYMPVLIKDPKYLRDPKLFDPLKPIRPHSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYN2</accession>
    <name>A0A183GYN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS342</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000106">
        <property type="protein sequence ID" value="VDO25471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYN2"/>
    <dbReference type="STRING" id="387005.A0A183GYN2"/>
    <dbReference type="WBParaSite" id="OFLC_0000034101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000034101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000034101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF299">
        <property type="entry name" value="GEM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="559"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO25471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000034101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="767" mass="85387" checksum="16FDDCFBD0954C72" modified="2016-09-07" version="1">FFILVTCTDDLCLRLIFHLQEYQLYTNHLHVLQLEKKANQFSFHDEDDTESTCSSSTQEPIAPDGGYGWVIVLASFLIHFICDGISFSFGIMFTEIQEYYNVTKTMSGIVGSIFLSIPLLSGPIAGALTDIYDCRRMTIVGGLIAAGGALISFFAFSIWHFLFSFAFITGIGLSFCFNTAIVAVTYYFQKKRAIATGIAVCGSGVGTFVLAPFIEVLFAKFGWHCSLVCIGFLLLLLVGCGFMIKDLEWPHDTIEYKKKKFIEKTEREKLRLAIKNAGDNSSAFNVDFPYIGSATRRTISLPSIPTYAIPFLQVIDQSSNVQSTLNELQLPVSKSYSMGEFLHVPVNGTTREQALIFNVSRIGQHNSGVHDVEIDTSLRSSRQICSKENYHTETGDLISNQVSEVDTKFSKTTSCAGDDDIVDDIVGSGQSGLIHEKLEHTVNYNSLQEDATKQPLLGNNIKKGKSATQTVKTSEDIIPSFTNRTVRNSYIVTSLGGAQGRVPATNVLYFRWKFVPFGGGMSRRIPSAPAICNRRKRKQGTIQLSKMWESFLEWLSNTKLVLVVPEFFVFLLSTFILYVFFDIPYVNFPEYAVEVHNVTETEASYLVSSIGLTNMVSMLFCGIIADWNRTSQYIIQTYGIFITLAGLCVALAPFAASYIHLMTLCIGFGFFISANYTLASVITIQILCLYDFQTGYGILCLVEGLGNLVGPALIGFIRDNLTSYDNIFLLAGTGMMISGLMVVAIDIFMRIYDTDHERKNSMRRDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZL1</accession>
    <name>A0A183GZL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS671</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000245">
        <property type="protein sequence ID" value="VDO26653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZL1"/>
    <dbReference type="STRING" id="387005.A0A183GZL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000067001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000067001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000067001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF34">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO26653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000067001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28369" checksum="2A621CA6B6563FAC" modified="2016-09-07" version="1">QVIIIIIKIIRSDSFSNGVITQHIALPTCRYQVLMDGPHGRPVKYTTVGEQVYHQWSCADEDGRVPETNLYCTTVHSCVAKEENGKEVQLLDENGCAVDKYLLNNLVYTSDLTGGQVSQVFKFADQSSLYFHCQIRLSLRRGSCKRTSDDCSARSARGKRELSIPSQQSDIDEAVVDVFSQLMTVFDIDDPINTDSLKRFEAKELKHITICLTPVSFSFLLAIFATELLISTLSITVLYRRICYKQEYCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0D2</accession>
    <name>A0A183H0D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS942</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000389">
        <property type="protein sequence ID" value="VDO27672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0D2"/>
    <dbReference type="STRING" id="387005.A0A183H0D2"/>
    <dbReference type="WBParaSite" id="OFLC_0000094101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000094101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000094101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO27672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000094101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16348" checksum="8AE4F9B3BC1BBECB" modified="2016-09-07" version="1">MCDIYSASDVACSTASILLLTVISFDRYRAVTHPISYSHKSHDTRRVIFIMAVIWVISLALASPIVLGVNIRPSDADPYECRFYNPIFSISSSIISFVIPCFIVLFVYIRIMIALRQRQKLSEKQYSSYLWPTKRLELFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Y9</accession>
    <name>A0A183H1Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysophosphatidylserine lipase ABHD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1499</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000717">
        <property type="protein sequence ID" value="VDO29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Y9"/>
    <dbReference type="STRING" id="387005.A0A183H1Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0000149801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000149801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000149801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000149801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19194" checksum="C5C597BC495A78C5" modified="2016-09-07" version="1">MTNYYCYNLGFGDSNGYPSEAGVISDSIFLFNYAKNFAGKNYIFIWGHSMGSGIAIAVAMELSMKKMPPAGLILEAPFNNVTDLITQSSHSAAWRWTPWFNVITCPILIMHAVDDEIIAISLAKKLREAALSANRDVTFISFAAERGLLHKHINKASELPLILKFVLFLLCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H221</accession>
    <name>A0A183H221_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1531</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000735">
        <property type="protein sequence ID" value="VDO29881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H221"/>
    <dbReference type="WBParaSite" id="OFLC_0000153001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000153001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000153001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000153001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9448" checksum="132C3A13FE4C0A1D" modified="2016-09-07" version="1">MPNDLAFNRQYSEEEQSIDMRREGTEEERKMQMDERMLSTAFSFPTEVIEFLSAVIMALITLSSQLHFTTQSNMSQSTNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2N0</accession>
    <name>A0A183H2N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1740</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000877">
        <property type="protein sequence ID" value="VDO30619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2N0"/>
    <dbReference type="STRING" id="387005.A0A183H2N0"/>
    <dbReference type="WBParaSite" id="OFLC_0000173901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000173901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000173901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO30619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000173901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48712" checksum="35EB9D63D027E93F" modified="2016-09-07" version="1">MGQLKSKILHQAGAENIDNLKEDPDDQWSNLYRELTGGELIAAFEKEGEDGVLKFANEKLISMMYEDGASPQMIRFTDYAKWKKTTNVQLGKTESNFVGQFGSKFREHLGQWRLNKRGVEGETIIHLLLNREEPMCSEIARILITRYPGLANDIYLGDEMFGQSALHLAIVHDDYETVHLLLQNSAEVNARACGTFFLPENQKTSRKSTDYQGYAYYGEYPLAFAACFGNKDIYDLLIQYGADPNLQDMFGNTILHIYAVRHWAKPADPNIVNAAGLTPLTLATKLGRKDIFEEMLELMKVVRTFTEFWRFSDMTCSAYPLTALDTIRPDGSTNYDSALMTVINGSTGEHLDMIGSEVIQRLLADKWKAFASRKLFERLGLLILHLIFLCFVVYMRPTDPERLMYKLYATEWNDWVYYFHCFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H467</accession>
    <name>A0A183H467_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2277</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001274">
        <property type="protein sequence ID" value="VDO32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H467"/>
    <dbReference type="STRING" id="387005.A0A183H467"/>
    <dbReference type="WBParaSite" id="OFLC_0000227601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000227601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000227601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000227601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29543" checksum="5D050BA3C6AC619D" modified="2016-09-07" version="1">MNKQIYSSKKKTDRQIYRYHCSQCSLAFRTEQRLASHTLYHTFRTSTRCTKCDQSFRSHELLKRHNTQEHTNGKTYSSPTTSSYQSQSVETTTDNKMEANHVDLLRPFKCELCKENFEQKHQLLIHYNSVTHLHKAKKMLEEQSNNFQPSAQILAALQASTSSQSLQGGSKPFKCNLCKLGYGQGSTLDIHIRSVAHQSRLTKIAELLAQGEIDGSKSIIEQPGGPTQTMLADLAIKPDSTTDALQVHSAFLVELPDKLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4T9</accession>
    <name>A0A183H4T9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2499</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001447">
        <property type="protein sequence ID" value="VDO33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4T9"/>
    <dbReference type="STRING" id="387005.A0A183H4T9"/>
    <dbReference type="WBParaSite" id="OFLC_0000249801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000249801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000249801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF76">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="350"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000249801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48407" checksum="1868936E3D62B28A" modified="2016-09-07" version="1">MKTESSTAEFKLKSTDCQQGSSVLGQTSEIFNQQIVRNSFPDLTNILIPEVRFHPSPFRLLPFDCSSTENNFKYSRCSQFISPLYLASPKRIHSSQIASATLNKSVSNGLNSFGGLMKTKQLQLKHTQRRPAFKKFDVLKNVLEMRTSSGSSSGNLYNLLPITRDIEKCRGDNEDEIENEENEFSFRIHLQDISRSSMISPSLPSTSALNELKSCYKKRHILEEMDDTGCVKKMKEEPMEESFEGMDIDMAESSRKDQDRAIENVKDEYDLSGSEPSKENVSISPAYHRSHSSNFLGISEIKKSGSTPFFLEVQYELDIIKNPDVPSSAFACISAETLAELLMSMTMEKFLQRFILIDCRYPFEFLGGHIRGAYNLFDPATVEAAFYPNNIEQRAQLMTKKLIFYCEFSQKRAPSMHVNFKCKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H615</accession>
    <name>A0A183H615_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS2926</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="UZAJ01001817">
        <property type="protein sequence ID" value="VDO34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H615"/>
    <dbReference type="STRING" id="387005.A0A183H615"/>
    <dbReference type="WBParaSite" id="OFLC_0000292501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000292501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000292501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="12">
        <location>
            <begin position="219"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="167"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000292501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41144" checksum="45B1E913B440D3A8" modified="2016-09-07" version="1">MAFMQQIENIACIGAGYVGGPTCAMIAYKCPEIRVTVVDMNAEKIKQWNSDYLPIFEPDLDEIVKSCRGKNLFFSDDIPSAIRNAQLIFMSVNTPTKTYGKGKGMAPDLKYVESVSRAIAEYSRGPKIVVEKSTVPVKAAESISAILNEAQKKNPQLSFQVLSNPEFLSEGTAINDLANPDRVLIGGESSPDGLAAMTQLIQIYEHWVPREKIITTNTWSSELSKLAANAFLAQRISSINAISAICEATGADIREVSYAIGRDTRIGNQFLQASVGFGGSCFQKDVLSLVYLAGSLNLHKVADYWLQVVEINNWQRRRFADKIISEMFNTVSNKRIAVFGFAFKKNTADTRFLPLVTYKIFKFMIVICEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6V3</accession>
    <name>A0A183H6V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3215</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002082">
        <property type="protein sequence ID" value="VDO35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6V3"/>
    <dbReference type="STRING" id="387005.A0A183H6V3"/>
    <dbReference type="WBParaSite" id="OFLC_0000321401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000321401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000321401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000321401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10966" checksum="AAB9B9ED5D1CC7B9" modified="2016-09-07" version="1">MSKIYEKSSIPAKGKIPKLISEVQEMDWKPIDQEKTDDERYGRYENRKLNTKKNAEPAIECIRNKRSEPLNQADQKEIKQTARNKFTPITTDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H737</accession>
    <name>A0A183H737_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3299</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002167">
        <property type="protein sequence ID" value="VDO36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H737"/>
    <dbReference type="STRING" id="387005.A0A183H737"/>
    <dbReference type="WBParaSite" id="OFLC_0000329801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000329801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000329801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22770">
        <property type="entry name" value="OTU_OTUD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000329801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41749" checksum="DBE3BC1FE1B78FD9" modified="2016-09-07" version="1">MARKKEYDGMTTDASSTTSSSGKRISKSNMPNDAQCKMDINRLNSISKRKEISSSSVISPSISRVVVLMYLVVLIVMILTSVANYQAAYPETSVRSVYDVADLRAQLGSFGLTVRDIPGDGNCLFRALGDQLDGHTGNHLKHRLDTVRYMINHRSHFEPFIDVPFDRYVNDLSRPGTYAGQDALVAFARLHEVNIIIHQLNRPLWKIQGSEDSNAPEVHLSYHNGEHYSSVRRFGDIANTPAGIRILVPTTVPCCASHSIYTSTKPITSKASSGNMQQSVSKLRKNNADASSEGTIHRYLYGEDDFTTLVHEVMNRTGCRDATLAAEALIENSRDLDQTVDYLLSVALFVAPGGDGNLSKSKNQSDMEMTSESLSFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7D0</accession>
    <name>A0A183H7D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">39S ribosomal protein L33, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3390</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002249">
        <property type="protein sequence ID" value="VDO36332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7D0"/>
    <dbReference type="STRING" id="387005.A0A183H7D0"/>
    <dbReference type="WBParaSite" id="OFLC_0000339101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000339101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000339101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000339101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8076" checksum="028E5993FAE3CF21" modified="2016-09-07" version="1">MPPKSKYVIVQLASVVSGSTRIWIRERAADKFRGIFYDPAVGREVLFEEKQRVKGKATLPDNVKRHFNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7I1</accession>
    <name>A0A183H7I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3442</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002295">
        <property type="protein sequence ID" value="VDO36506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7I1"/>
    <dbReference type="STRING" id="387005.A0A183H7I1"/>
    <dbReference type="WBParaSite" id="OFLC_0000344201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000344201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000344201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO36506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000344201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50552" checksum="A768B08355E09EBD" modified="2016-09-07" version="1">MDDNEDIQEKVEKYKRMLSCDSKIGHALKRLANINMTLELLSETGVGKAVNQLRNHEQYGTKAVQIVEKWKDMARSCGLKQRRKGFLSPSSEREENLPKKSKKGNRRGEKGSKNEQEVYNNADEVHHNKAKSSNDGLGNAGSGLSFADMLARADTAKPFKLKKVKTDCNDWKSSKVDINYRPSKVLNFEPLPKERHTDISGTVMMDTSMFKPRKSVRKIYAGRPKNDIAKEVPTLLNLCIKVLIANINSIEEIGDTPYFILKPVLEKCSPNQLCLIERRNPQLMEDSDELWKRIVNRTFPKCEPANKEKWRECYYRLCEENERKLKLLSTKITQHNREATLPVKTALLADAKAPREIRRRQIRYGTQHATHPLPSAIEISKARKEIFEKGNKEGLAHLPQSIRNISSSLDSPSHSEKKKIVPKKGILMMKTLRMLNVKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Z2</accession>
    <name>A0A183H7Z2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3605</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002470">
        <property type="protein sequence ID" value="VDO37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Z2"/>
    <dbReference type="STRING" id="387005.A0A183H7Z2"/>
    <dbReference type="WBParaSite" id="OFLC_0000360301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000360301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000360301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF175">
        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Macroglobulin" evidence="7">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Macroglobulin" evidence="8">
        <location>
            <begin position="208"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000360301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56498" checksum="460CCAF39ED9F611" modified="2016-09-07" version="1">MKMQCFNPGTFLVIAPKVVRPSLPYAVSVNILKSSEADHIVRVEIRTVQNDTVGARVVNNVKTGVPQTVTIDALSPEILLPGSAYKVYVRGETLGSNILFEAEEEVRFDGKSLSIFIQTDKAIYKPGSTVRYRIVVVKPDLKPYSETVSVMIRDPNQNIISQKNDQSLIKGIYSNELELSVEPPLGDWQIIVKTKSGIKFEKEFTVDKYVLPKFEVNVKTPNFITINDDLSVHVEAKYTYGKGVSGKAKVTLELPWNHFAVPIIVTDDGTVEKTEQGNVIERIVNLNNMGEAIIVFTNEELKKHKLVTGYGGSSVKITATVTEDLTDIKRNATTQIIAYRHDVKLEMEKQGETFKPGLGYNVVITLKQMDDTPVKATVPKRVQVTTFYSYLYVTDSITQHEEKEVKIVDLDAHGSAVITLQPPNNCTDARVEVCFSFYFNLNCLFFKLIFDPFQSYSILPIFFFCILTFFWKRMENKTNFSFILKKLIFNFNFILKNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAI8</accession>
    <name>A0A183HAI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003445">
        <property type="protein sequence ID" value="VDO40164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAI8"/>
    <dbReference type="STRING" id="387005.A0A183HAI8"/>
    <dbReference type="WBParaSite" id="OFLC_0000449901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000449901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000449901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000449901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30566" checksum="5A1BADB85CD65945" modified="2016-09-07" version="1">MVLFYDHISESVNVTDQVLLDEFYHITSENILPIDSLSKWIILRYEDPTHYYTLRKQVALNMSVLSICEYILHLNPATMHGLCLNMKTGQIMNVDYLFGLKPQTLELEVDRIVPYRMSPNLHKFLGFSIEGHYNCSIVATIRCLHARKIVTYAQLLLWDSISRQKKLPMAEIFKLTRNAAKLMESRLNGIISDSFHRNFLFIPFVFTAFFDLYGLCFGAPLFLNISDLYKKESLAEYISQLTQTARKDENLARLDPRLHPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAQ6</accession>
    <name>A0A183HAQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">39S ribosomal protein L13, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4568</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003526">
        <property type="protein sequence ID" value="VDO40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAQ6"/>
    <dbReference type="STRING" id="387005.A0A183HAQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000456701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000456701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000456701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552463" evidence="4">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000456701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10175" checksum="2DEF8BD89193FDC7" modified="2016-09-07" version="1">MRRVQQWLLFARQWHLLDATGQDVWVLGKKVANYLAGKHKPIYHPFTDCGDHVVVINCKDVAMHGFNWKNQRFFFDKVCSIFNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBM1</accession>
    <name>A0A183HBM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4883</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003932">
        <property type="protein sequence ID" value="VDO41337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000488201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000488201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000488201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552472" evidence="1">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000488201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37697" checksum="60C4D3B573C5661E" modified="2016-09-07" version="1">MPCCYLLPNVYLIMLVYCQFVTAKQRFERYALPTDHIVVHSSNSNVSVTDWVVVISDESKIEFQEKFLRGKVWSGNSTLYFQPHGQTENFSAHNDVFSIFELSQVMLQTKCEQIQMFLRSNRSTDGHSYMEYRADKNVNLIFSSGITQVNAFSGQWAHVSVVTWQLPVSSQVTIGSNILSNLSRQLYIASVSSNYNINITAFDAQMQMRYGNITVHITPDYRFLRIRSELYVVNLKTIISPFEISISDHEMIVRCENEQAIVQLLPNSSNIIIGTNQYSKMIIDRGREAVILGGREVRPAGNINLLSMQLKILLKSGNISFIHASTNRSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBP9</accession>
    <name>A0A183HBP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4909</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003970">
        <property type="protein sequence ID" value="VDO41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBP9"/>
    <dbReference type="STRING" id="387005.A0A183HBP9"/>
    <dbReference type="WBParaSite" id="OFLC_0000491001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000491001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000491001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF9">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000491001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="391" mass="45085" checksum="C47398CE2EF3063C" modified="2016-09-07" version="1">MTTRSGRKDLKSEPTSDDESKLWLNSIENERNRRPRRAHKAPQRYGDYIDETNRDAARLNLSDIPGFEPEAEEPDEEERPRRSHSTSMRKRSFDENVSEGQEETNEEGEDNENEFFEDEELVDVEGREEEERLNETAEESTKKDENQKSSGGQKRKLQCDRCNRYFANHNSMNAHRFKVHRVVVRASVKCPGCEHRATTIHTLNEHVADEHGIKLQYVKRKFKNTGEFQNYLDDLAVTRNMGFVLHRKSENKRQLYCNRSGAIRVSKGNSLRNRPRKGTAKIGAMCPAHLFYTECDDGSIEVNGQLAHFGHALDPRFVFPATSSEKVSARVRLTRPKRDLLHRSVPVDLQDHTKNTGSDDGSFVNVDNDNTNGFDEVCYHNKLIIFIFSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBV3</accession>
    <name>A0A183HBV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4965</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004051">
        <property type="protein sequence ID" value="VDO41612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000496401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000496401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000496401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000496401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8254" checksum="F005BF43A3A9785C" modified="2016-09-07" version="1">MNWMSEWIDGKERTDTYTRTQTHYTPGIHNLDNDDGDDNDDDDDNDDNDNDNARVLSGTPKLWFVMESKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC12</accession>
    <name>A0A183HC12_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS5025</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004115">
        <property type="protein sequence ID" value="VDO41801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC12"/>
    <dbReference type="STRING" id="387005.A0A183HC12"/>
    <dbReference type="WBParaSite" id="OFLC_0000502301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000502301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000502301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="120"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO41801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000502301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27004" checksum="3D529417B6524C2D" modified="2016-09-07" version="1">MEGVYIEEALQDVLKETDLVNFERKLCVELQLSRLEHFDHVTDDELKSYTGLSQPAIRRLRVAIAEKKKKSKKSKGIFSSIGRKESHEVTKVLVPTRGTAEVFWPFPENGSTSLIIKEEIKLMERLGEGSFAVVKRAIWTPRTGRKLDVAVKILRDSTPEIIEDLQREVTNMQKLKHPNLIQLYGVVFSNPAMMVTFFQFALQFVFLNKHYSKNCGMTSSSSMFRHFNLLIIIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCG3</accession>
    <name>A0A183HCG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-dependent RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004307">
        <property type="protein sequence ID" value="VDO42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCG3"/>
    <dbReference type="STRING" id="387005.A0A183HCG3"/>
    <dbReference type="WBParaSite" id="OFLC_0000517401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000517401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000517401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000517401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31724" checksum="5BAE98D6F308CEF4" modified="2016-09-07" version="1">MGISLLDVRVESGEVCTMVFRKFKPQKQWGRMDTRIFKNILAARNKRKMPRFIVSPAVEEAGIKIYDPNRPNFFTTEVRELPAISHPVHRIPQLDEHPLYKSVECSLFDGTVAFTDGIDQACALSKAVKRIGFPETVSNLASKIPLPESFEDHLSDCIMHGERYDPTLEKLPRLFDPVIFWANYFPHRVHGTPVLTRGKIILDNLFRTAHLMALQHSQLLNLRYDRDEPLSAILQVDTVENEKIPFVLRSEPHIIVQSPEPIRPWTKAVGSKTCTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCR8</accession>
    <name>A0A183HCR8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5281</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004459">
        <property type="protein sequence ID" value="VDO42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCR8"/>
    <dbReference type="STRING" id="387005.A0A183HCR8"/>
    <dbReference type="WBParaSite" id="OFLC_0000527901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000527901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000527901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000642">
        <property type="entry name" value="Serine/threonine-protein kinase srpk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000527901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31698" checksum="523E34058D93786A" modified="2016-09-07" version="1">MDSDARSEIEMKESALQLLLEKDGLSPRHVEPDYLNPATEINVKLADLGNACWTHHHFTEDIQTRQYRSLEVLIGAGYGPPADIWSTACMAFELATGDYLFEPHSGDTYSRDEDHLAHIIELLGTISPRIYKKGAHWREFFDKHGRLLHIHQLKPWSLVEVLTQKYDWPIESAGQFASFLIPMLAFDQDERATARQCLQHDWLKPNGGKPLRAVEKQQAQESSQKQKQPSILDPSPLDESSELGGDSDNAEGEEYFVTNEMHATSLVKESQQSVSTNGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDE6</accession>
    <name>A0A183HDE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIP49_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5508</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004771">
        <property type="protein sequence ID" value="VDO43405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000550701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000550701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000550701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF2">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM69 protein-kinase" evidence="1">
        <location>
            <begin position="180"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000550701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37853" checksum="B26CDEE199C40D0E" modified="2016-09-07" version="1">MTFIFSLLTLYLIYSSNLLKYQFLLIASNFLNITDWNSGAIVQTGVAPMNFTDFRAHQILLDLCKAYAQQKLSGDLCNRLCYYKKWNILDIYQGNKIVITIKDGGQEVVLKSQHSNINEFEHLDPRVNESLFFDAILGVVNYNLRLGWPSHYKHHLIETLWPMYVRKGRSSLSEADRRSLWALLSQDEYITFRVLPLTRVTPKIIGTCGHFYQVETLVPFHMKGYYMNLKAKILLHLMGTLKLFDEFLNEPLQWCDIKFDNLGLAADYPKRFMVMDADMLYTKSRLKAVLTNRMCQQDTDCHYFDCYAKCNNETGFCGDRTNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEA8</accession>
    <name>A0A183HEA8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5818</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01005211">
        <property type="protein sequence ID" value="VDO44445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEA8"/>
    <dbReference type="STRING" id="387005.A0A183HEA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000581901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000581901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000581901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO44445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000581901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="11919" checksum="78459FEBBA45C3AC" modified="2016-09-07" version="1">MTVIGRMSVALQGLTRNMQFCSQRLTSSAPKIALLGAAGGIGQPLGLLLKMNKHVAKLALYDIKGTPGVAADLSHIDSKAHVTAHTGPNELNEALQGADIVVIPAGLPRKPGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEE3</accession>
    <name>A0A183HEE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005266">
        <property type="protein sequence ID" value="VDO44578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEE3"/>
    <dbReference type="STRING" id="387005.A0A183HEE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000585401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000585401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000585401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000585401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11738" checksum="F0A5DE034E842336" modified="2016-09-07" version="1">MGQADRVVMIGTASKGIIDRQHQHNAQVYRQLYAPNPFASETDEDIQKYMKEVEAKTPRPSSAADSTERTTSSLPLYENDSPSVGRLCFTVVPGVYLICNLKQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HET1</accession>
    <name>A0A183HET1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005460">
        <property type="protein sequence ID" value="VDO45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HET1"/>
    <dbReference type="STRING" id="387005.A0A183HET1"/>
    <dbReference type="WBParaSite" id="OFLC_0000599201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000599201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000599201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000599201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40220" checksum="EAA3509D0368524B" modified="2016-09-07" version="1">MTLSKKERKFISRCRDSVEFSLECCWLLDAYGANTFRKFEQKSHGYRLRQSILNEFRERPYNLETTAMYFSPSAQRHSRAVSETTHYRIIDKTQYIIPKMQDNDEIITNKNIPGTKIFGDLTSGSAFDNGCSCFDNEQCKFDKENVINTECKCEALKIQPEQEFVKALMNIGNKLKIFTSKDERTRCLVDELCKINVNLPARVWLPLYAHSLKHIILRIPPLDGCILNSKDKAPYCLFVEVLEVSDIRQTKVPKRISDIEAAEYHRKSRDIFASVMKDTATESRKNSKEIRTKSNDPIFADMFLKRLSSTDIALESKEKRNTADIRKRFSLWAKDRKRQVSFVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HET8</accession>
    <name>A0A183HET8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5999</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005461">
        <property type="protein sequence ID" value="VDO45080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HET8"/>
    <dbReference type="STRING" id="387005.A0A183HET8"/>
    <dbReference type="WBParaSite" id="OFLC_0000599901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000599901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000599901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000599901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14211" checksum="02CE5CE164690D22" modified="2016-09-07" version="1">MNDTEHLDELRNYKFHRIRTVASVYHTLARDRYNRQSREKLNMSTTEVDPNMTTPPPRGLLPKRLFLNSPESPSHFPITPKSRPVEDRRRDAAGKSVCRRLFGEDDFRKNDPAPGPSTRHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG38</accession>
    <name>A0A183HG38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006135">
        <property type="protein sequence ID" value="VDO46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG38"/>
    <dbReference type="STRING" id="387005.A0A183HG38"/>
    <dbReference type="WBParaSite" id="OFLC_0000644901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000644901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000644901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000644901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10562" checksum="37675D96204FB6CB" modified="2016-09-07" version="1">MNMLIDPIEEEKREQEWTRRVLDKFRNQDFNKLVEEMHQEREEVDLSRTVKRLLQRNDDASRMNECGSYNKPKNIFELKLPESFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG55</accession>
    <name>A0A183HG55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CTP_transf_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6467</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006158">
        <property type="protein sequence ID" value="VDO46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG55"/>
    <dbReference type="STRING" id="387005.A0A183HG55"/>
    <dbReference type="WBParaSite" id="OFLC_0000646601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000646601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000646601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000646601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30511" checksum="86FA137E9CE401D3" modified="2016-09-07" version="1">MDDVGLLIVGPKFLQNIATVLADASKTITDRLYVRVAAELDLFEVLSQVYFEGSRICDTLDIRVIIDDNRERKFKTIICEDETIEYNRTIDKPYGAVVLGGTFDRLHNGHKMLLSRAVMAASERVVCGVTCGDMIKKKILWELMEPFEKRAKAVQEFVEDISCSVRCEVHPIVDPYGPSIIDRDLRAIIVSNETEKGGHAVNDKRKERNLPILDLIKISLIDGKDELTGEYKLSSSTRRRALLGTFLKPLKLEKFPRPFVIGLTGGIASGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGG4</accession>
    <name>A0A183HGG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA_28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006336">
        <property type="protein sequence ID" value="VDO47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGG4"/>
    <dbReference type="WBParaSite" id="OFLC_0000657501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000657501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000657501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000657501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16291" checksum="9985E76ABF04E258" modified="2016-09-07" version="1">MIQADQIVTKRHIYKIVLTGGPCGGKTTGQDRLRTFFEEMGWKVYTVPETANILLSGGVKFAELTQKQAYEFQKDLLLTLLRIETVFFNQANASNAERILIICDRGAMDPSAYIDKKSWAQILEEVNLDQFSLREDRYDQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH68</accession>
    <name>A0A183HH68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6830</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006732">
        <property type="protein sequence ID" value="VDO48044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH68"/>
    <dbReference type="STRING" id="387005.A0A183HH68"/>
    <dbReference type="WBParaSite" id="OFLC_0000682901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000682901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000682901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000682901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11829" checksum="D31505CD48C2CE30" modified="2016-09-07" version="1">MLIWEWRRKWRQYIRNRRPPSRLTYQELTKRYTRVSFVLFVVGWHAIGFVIWRKVEKWKKDNPQEKVLLSEIPKKGFMELSEEGKEDIDFEDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH4</accession>
    <name>A0A183HHH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6933</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006911">
        <property type="protein sequence ID" value="VDO48532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH4"/>
    <dbReference type="STRING" id="387005.A0A183HHH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000693501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000693501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000693501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO48532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000693501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30468" checksum="3AF97024E0BE01EC" modified="2016-09-07" version="1">MANGASRGTNHEMHFREFLEKTDGRDWVVIRNMIGLDYEQQQNYTLTITAMDMRSLITSDKQFHVVVRDKNDVVPRFTVDLYTGTIEEEQTPTEFLIKYNGNPITVVKAEDADSPGPQSEVRYRIIDDGDTGATKLFRIDELTGGIFPLEIFDRERNDSFIFDVEARDSIPSSLPGTSGPNRDIVKVQIFVADINDNAPNFEQIRYEARVAENAEINEDVITVKAYDLDRLSNLKYDLYAVHGGRIPFGVRTDSGALFVKEPLDYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHZ8</accession>
    <name>A0A183HHZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007202">
        <property type="protein sequence ID" value="VDO49380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000710901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000710901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000710901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000710901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9510" checksum="13379C5C2F836931" modified="2016-09-07" version="1">MVLLEHKVLQECVENKVNEASMVYQDYEDHQDLPGHKETKVVVIIVNHRQTSQYRKILPKIAIKSCKIINQLNRKSRDIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIL7</accession>
    <name>A0A183HIL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7331</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007567">
        <property type="protein sequence ID" value="VDO50436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIL7"/>
    <dbReference type="WBParaSite" id="OFLC_0000732801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000732801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000732801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000732801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11891" checksum="E41285CABDCCC9E3" modified="2016-09-07" version="1">MKRFWKWVVGQKNTIQKWQSTVLHPDRNEKRDRRRLKPTGGSDNELERNEKRNSKILQEDSDNYNMSISLRDLNTSYENEPIDFEEFFEESLLAIESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ07</accession>
    <name>A0A183HJ07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007824">
        <property type="protein sequence ID" value="VDO51143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ07"/>
    <dbReference type="WBParaSite" id="OFLC_0000746801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000746801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000746801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000746801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9177" checksum="61175D65498FB44F" modified="2016-09-07" version="1">MDGWKIETSSLRTYFFLIQPVSSGIEIIKNGKRNGAEERGRRIRTIRHFPEEAAAPVQHNNTYMNQQQPSVIYSRCCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJY8</accession>
    <name>A0A183HJY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ariadne domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008378">
        <property type="protein sequence ID" value="VDO52550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJY8"/>
    <dbReference type="STRING" id="387005.A0A183HJY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000779901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000779901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000779901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ariadne" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000779901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14594" checksum="EDC1F2998AD4AF30" modified="2016-09-07" version="1">MNHQQSLKLEHKLYSIVKSKMEVMQQANMSWIEVQFLRKAVDVLSECRRTLMYTYAFAFYLQKDNQSVIFEENQRDLEHATEQLSEFLERDLDHENLVSLKQKVFLFALFHKSRLINHIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKP8</accession>
    <name>A0A183HKP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8059</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008837">
        <property type="protein sequence ID" value="VDO53846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKP8"/>
    <dbReference type="STRING" id="387005.A0A183HKP8"/>
    <dbReference type="WBParaSite" id="OFLC_0000805901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000805901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000805901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12353">
        <property type="entry name" value="RRM2_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001013">
        <property type="entry name" value="TIA-1/TIAL RNA binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO53846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000805901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17591" checksum="F441AAD44A7E0C81" modified="2016-09-07" version="1">MNKRVLLEKEMKVNWATEPGSQAKVDTSKHFHVFVGDLSPEVDNKALKDAFAPFGEVSDAKVIRDATTLKSKGYGFVSYPKREEAERAIEQMNGQWLGRRTIRTNWATRKPTGTGAGDGQYGRTELNYDDVYNQTGPDNTSVYVGNVISSANGKSLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKQ4</accession>
    <name>A0A183HKQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8064</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008845">
        <property type="protein sequence ID" value="VDO53874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKQ4"/>
    <dbReference type="STRING" id="387005.A0A183HKQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000806501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000806501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000806501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000806501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25619" checksum="02928C65D2931905" modified="2016-09-07" version="1">MESETVFHACASLLKESYEEVGEVILHKLLNMLNKCSELTDSSFDSIAAELVPSLLQIIRKSSLVECRYLASLALGSLGAIDPGRIGLSLARSNNGDQHNVRFVFVDSGEQFYIELLERAAVAFSGVLDASMQVECSYSIQTVLQELLGKHSSENSHLWDLLSEQCQNSLSMLRKSNFILHKPFQQLPSKRPIIECEQVKDFRSWLNLWYKITAAKVGDSFFYSFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL87</accession>
    <name>A0A183HL87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8251</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009178">
        <property type="protein sequence ID" value="VDO54784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL87"/>
    <dbReference type="STRING" id="387005.A0A183HL87"/>
    <dbReference type="WBParaSite" id="OFLC_0000824801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000824801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000824801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO54784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000824801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12411" checksum="82300C402755B353" modified="2016-09-07" version="1">MPSEIIAIQFGQCGNQIGDAFWRALCAEHGIASNGEPIQSDLDAKDLKRVFFYQADDERYVPRAVLVDLEPRVINGIITSDYRTLYNMENIFMSKSGGGAGNNFASGYKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLK1</accession>
    <name>A0A183HLK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Coatomer subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS8362</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009390">
        <property type="protein sequence ID" value="VDO55297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLK1"/>
    <dbReference type="STRING" id="387005.A0A183HLK1"/>
    <dbReference type="WBParaSite" id="OFLC_0000836201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000836201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000836201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="11">
        <location>
            <begin position="53"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="12">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO55297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000836201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28470" checksum="46DF906657448AA0" modified="2016-09-07" version="1">MGMSIKILCGKWPEAEVVFLQKCRDSLELMLESKSENERFESEIANRTAEVSVDRTISFTQLAPRVGDGVTGTENLFDLSLSQALGTVVKSPKFDFASSKLGKVKQLAGFSDPVYAEAYINVNQYDIVLDVLIVNQTNDTLQNVCLELSTVGDIKLLDKPTPLTLAPRDFSNITATVKVASTENGVIFSTIAYDVRGSTSDRNCVYLEDIHIDIMDYIIPGNCTDTEFRHMWAEFEWENKVRLSLCFSFILVPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM19</accession>
    <name>A0A183HM19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo/beta-catenin-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8530</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009728">
        <property type="protein sequence ID" value="VDO56130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM19"/>
    <dbReference type="STRING" id="387005.A0A183HM19"/>
    <dbReference type="WBParaSite" id="OFLC_0000853001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000853001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000853001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO56130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000853001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23087" checksum="D58A4F2213B7E324" modified="2016-09-07" version="1">MRAALRALGNLIAGGDNQTQAVLDAGLLPRMMKLFQINMPVNQRREIAWILSNIAAGSHRQIDLLFETNDIIEILMDAFDCDDHRIRKEIGWTITNALTGASLNRSRWLCGSNVLTLIPELLNMHTEHDLIDRTLHAIELLIAKRNAYIFILENYQIIQSIRRIVQNDNNQSPIKTRATRILDKESDYKACQIPANIYTLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM99</accession>
    <name>A0A183HM99_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8612</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009889">
        <property type="protein sequence ID" value="VDO56518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM99"/>
    <dbReference type="STRING" id="387005.A0A183HM99"/>
    <dbReference type="WBParaSite" id="OFLC_0000861001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000861001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000861001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="10">
        <location>
            <begin position="259"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO56518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000861001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36771" checksum="FAB386B4B750D5FB" modified="2016-09-07" version="1">SLYRLVIYSFHINNSIFFAGIDSSDGSILWYLYLGKNIKPLFCSLGNEKIPLFIQRTTAHFHFSPQATVIANDKESGQAVLICFNPITGSLIEQKSLLTSIKRVEILPYANAQTHIYHLIMLDENDKVISYPENIDGLEQQVPLHFFNFNTFGDLEGFAFNVSRKQLSSTWKAKLSLSNEQKIVAVVPKPSYQKVHSAGRVLSNRSVLYKYTNPNLVAIAVLDSVHSVLQIYLVDAVSGYIVYSGKQTKITSPVHLVHCENWLAYSYWNEKGRRMEIAVVELFEGLEQTDALHYNSLVHTLEAKVTVFSQAYIFPQGVAALGVTETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMK4</accession>
    <name>A0A183HMK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8721</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010087">
        <property type="protein sequence ID" value="VDO57051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMK4"/>
    <dbReference type="STRING" id="387005.A0A183HMK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000871501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000871501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000871501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000871501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21790" checksum="ECAE62FA6444CA49" modified="2016-09-07" version="1">MREKSVETVQNLVHEEPLPIFFGKFGTFSFGSVEVSRKLKPTRKPANKRQVTSDMDYHLVVNIHSALNLPEPEHGELLSFVEISFQDSVVETSVCRGQNPYWQQTLELKLDRLRTDNNNFGVIMDSIKIAVYDRLVTKLDADDREPNSVHEQLERRWLGSLCIPLTTVYFSGKIDGYLRLQTPLFLNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNB3</accession>
    <name>A0A183HNB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DHO_dh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8974</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010580">
        <property type="protein sequence ID" value="VDO58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNB3"/>
    <dbReference type="STRING" id="387005.A0A183HNB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000897401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000897401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000897401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO58230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000897401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19869" checksum="AD07E7D2010CF6AD" modified="2016-09-07" version="1">FFFLDAEAIEGLRKSGFGFIEVGTVTPLPQKKDSDSMVKRLSGDEGYISRGRFKSAGLGNVYLFVKKAYDRNAVVPLGVNIGRNAGFNRLKADYNLGTYYFGPFCNYLVVNFGSQAGLETITDLEIALQGVTSAVNQMIQANEPPPKILIKIPPDLLIADLKTIIKVCFLALALSVAPVSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP52</accession>
    <name>A0A183HP52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9264</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011184">
        <property type="protein sequence ID" value="VDO59422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP52"/>
    <dbReference type="STRING" id="387005.A0A183HP52"/>
    <dbReference type="WBParaSite" id="OFLC_0000926301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000926301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000926301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000926301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25993" checksum="028441B97C87287A" modified="2016-09-07" version="1">MSKLNERWDLINWKKIAKWFEDGIERCGVEAIKTNAVNEIRQEFNLHIKLISLFIPFVNKQLLSDKQQFTHYMQKYHESSIVLLNHFGWRREARAVGWELAKFLLSSDRAEGALPYLLNFISDLIADGSPVLLLRDTLLFTVNHLEKFPGIHFKELVDFYLILMKLAKTETERIKYCNKLLELSEKPNITKIRFYFLNLLKKKIAVLKKKDRNFRIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPD3</accession>
    <name>A0A183HPD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9343</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011354">
        <property type="protein sequence ID" value="VDO59858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000934401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000934401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000934401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000934401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10656" checksum="2C2E79F4F12C55EF" modified="2016-09-07" version="1">MSNPHELRYIFANAASLSPLSFSVIIQLDCMVLMVHLYYHSHCLTDAKRRNHSDRTFYYLKNGHDEKNGPTVNDVVPRNCGGKFGLGENFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPL4</accession>
    <name>A0A183HPL4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS9419</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011520">
        <property type="protein sequence ID" value="VDO60447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPL4"/>
    <dbReference type="STRING" id="387005.A0A183HPL4"/>
    <dbReference type="WBParaSite" id="OFLC_0000942501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000942501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000942501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000016">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="126"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO60447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000942501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35103" checksum="F2E165C0E9533EEC" modified="2016-09-07" version="1">NVVIHDEKIFSGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILKTHTTLEHSDCSFMVDNEAIYDICRRNLDIERPSYPNLNRLISQVVSSITASLRFDGALNVDLMEFQTNLVPYPRIHFPLATYAPIISAEKAYHESLSVIDITNACFEPANQMVKCDPRLGKYMAVCLLYRGDVVPKDVNAAIASIKTKRTIQFVDWCPTGFKVGINYQPPTAVPGGDVAQVPRAVSVLANTTAIAEAWARLNYKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYEEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQG4</accession>
    <name>A0A183HQG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DRIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9723</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012239">
        <property type="protein sequence ID" value="VDO62790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQG4"/>
    <dbReference type="STRING" id="387005.A0A183HQG4"/>
    <dbReference type="WBParaSite" id="OFLC_0000972501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000972501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000972501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000972501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20567" checksum="2D180982D06B4E48" modified="2016-09-07" version="1">MNEREKQNGVDSHILRLVLKGLHNPKEVIRHDFTSILVSTIACFPTHKQLRHLGSLRNTEEIDLDFFENVTHMQIHRRQRAFYKLTQDLQLEKIRIPNGVLLRFVLPLLQPYLVNLSSSTSALSDASLALFTQIMRGAPWKKYFPMLDFYLKRLRKESVNVNHKAIIRLVFKFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQM5</accession>
    <name>A0A183HQM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9787</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012369">
        <property type="protein sequence ID" value="VDO63257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQM5"/>
    <dbReference type="STRING" id="387005.A0A183HQM5"/>
    <dbReference type="WBParaSite" id="OFLC_0000978601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000978601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000978601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF823">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO63257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000978601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9695" checksum="A398CC450D239828" modified="2016-09-07" version="1">MDFTVDPIDVKYRSTVGSRVKPSFTDFKQINSFYCSNRCQMTNLRCRYGGYPDPNNCNVCKCPEGFGGQNCTDLQYSCKRTFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQN7</accession>
    <name>A0A183HQN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9796</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012396">
        <property type="protein sequence ID" value="VDO63347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQN7"/>
    <dbReference type="STRING" id="387005.A0A183HQN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000979801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000979801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000979801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO63347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000979801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13062" checksum="8B84710D633865E6" modified="2016-09-07" version="1">MDPILTSKMLVAFCSRPFCKLKKRLHYHCTFCEQGFSSADRFLRHFQKHYALIGSNFQSLSSDQMNETMKYLAFQKDFTGSFPVENGKQTLAKPLKFVDCTAETRAAVIGYVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQN9</accession>
    <name>A0A183HQN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS9801</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012416">
        <property type="protein sequence ID" value="VDO63412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQN9"/>
    <dbReference type="STRING" id="387005.A0A183HQN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000980001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000980001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000980001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO63412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000980001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22402" checksum="91E5F7305B043171" modified="2016-09-07" version="1">MMASVTAPKPCEPVFSFFLKFVISGSVWSCWRIKSTGPCLMDLTNFPMDSISCMLTFESYNYNIQEVRMKWNKPHAVLMFKDIELPDFTLVNYTTSIIEAEYAAGLWDELTVSFTFKRRYGWYILQGYIPTYLTIFISWIPFYMSPRAMPARTMIGVNSLLAMTFQFGNIIRNLPRVSYIKVNSLNVFRLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR60</accession>
    <name>A0A183HR60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9970</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012802">
        <property type="protein sequence ID" value="VDO64813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR60"/>
    <dbReference type="STRING" id="387005.A0A183HR60"/>
    <dbReference type="WBParaSite" id="OFLC_0000997101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000997101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000997101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO64813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000997101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18170" checksum="EF83BC2DB3493EB9" modified="2016-09-07" version="1">MTRQWLAYAVAQQFFGCFVTSTCWLDIWLVSSLARSITSMFVERFFGFSENLYQINKILNCVSDYETRWGMIVLRPSNTTYKQYLHFDPRNPYTCSPLYADALFKKGHLVMRMLNQRLGKEPFLQVKLNALFYLLTIFLMKDLLSIIAKIIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRY7</accession>
    <name>A0A183HRY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10249</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013455">
        <property type="protein sequence ID" value="VDO67050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRY7"/>
    <dbReference type="WBParaSite" id="OFLC_0001024801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001024801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001024801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001024801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12002" checksum="2549013D4E4986C4" modified="2016-09-07" version="1">MDSLSKEDSVLVINGKAVNDAYGLHEPVKFKLDDIIKVTKNKIDRTAKSVFNLNADDKKADFLTNFHSKIDNLIIRDVSLDKFDVKLDFSRDFIDLRGNGTVNNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT52</accession>
    <name>A0A183HT52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014441">
        <property type="protein sequence ID" value="VDO70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT52"/>
    <dbReference type="STRING" id="387005.A0A183HT52"/>
    <dbReference type="WBParaSite" id="OFLC_0001066401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001066401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001066401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001066401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15030" checksum="CCC1ED5637F06DF3" modified="2016-09-07" version="1">MLLLAPSTSQQTSPIITDPGRTIVQAPKPAQPVFVAPPNTVQIKRVMHSEVYLKYIESLSTSQQRTVSKYSRSLLANQRNTTPPQKISTTQWLKEAKDNGVRDEEVVKALWRLRDALLESTVNIAREMDCTGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTQ4</accession>
    <name>A0A183HTQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BIG2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014999">
        <property type="protein sequence ID" value="VDO72013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTQ4"/>
    <dbReference type="STRING" id="387005.A0A183HTQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001086601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001086601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001086601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUP210 fourth Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001086601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18330" checksum="ADD3A5DA98384042" modified="2016-09-07" version="1">MYIPENAVFESAISKEYFKVISKSRNGSYFNVRTIKSGTAKLRAAFVSVISSEGELRMSSSIKDEVTAVISEPIEVIPPFVAFPYIDAKKIHSKKLLARGGTGSFTWSSMHPEIASVDSSGILLTGNLGETEVIAQDVQNNAHFGKAVVQILQPTGIAFSKSHLEAEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU72</accession>
    <name>A0A183HU72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015414">
        <property type="protein sequence ID" value="VDO73312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU72"/>
    <dbReference type="WBParaSite" id="OFLC_0001103401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001103401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001103401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001103401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8948" checksum="C78BA4148BE96011" modified="2016-09-07" version="1">MNVASGCSMARNTENGRQYCQLLGLICPSERKISYDNITVECCCEGDHLCNHDMNSYHAFYALPKIMNVSFSFIFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUK9</accession>
    <name>A0A183HUK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11176</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015804">
        <property type="protein sequence ID" value="VDO74431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUK9"/>
    <dbReference type="STRING" id="387005.A0A183HUK9"/>
    <dbReference type="WBParaSite" id="OFLC_0001117101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001117101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001117101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO74431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001117101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14806" checksum="229B659AE02A7D34" modified="2016-09-07" version="1">MIKNSKFKTDNINKSVQIDEEKAIQDNHRVQMFDNKGQFAGKFGTMGPGIGQFHHPQFIAIHKRTQNIYVTDSSNHRVCIFDHSGNPIFQFGSEGYQNGQLKFPRGIAVDDQKQTNNEARNVSNLSVIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUW9</accession>
    <name>A0A183HUW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016099">
        <property type="protein sequence ID" value="VDO75270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUW9"/>
    <dbReference type="STRING" id="387005.A0A183HUW9"/>
    <dbReference type="WBParaSite" id="OFLC_0001128101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001128101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001128101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001128101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9569" checksum="AE63A87E5421DE5A" modified="2016-09-07" version="1">MGGMDIEKHIDYGTAFISSSKTLNEFFGYLILLGPVAVITIFGFVAFYINAIIYKMPWGTIMDATTDWISHTSIRQTKWTTILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV07</accession>
    <name>A0A183HV07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS11320</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016222">
        <property type="protein sequence ID" value="VDO75610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV07"/>
    <dbReference type="STRING" id="387005.A0A183HV07"/>
    <dbReference type="WBParaSite" id="OFLC_0001131901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001131901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001131901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001131901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14609" checksum="7A66EDE9B17B4500" modified="2016-09-07" version="1">MMASSTEEDDHHAEDPHKSDLWQQTLQAAVAATSQSEAAKKRQQQRKPMRQSNVVERSERSLLCLTLSNPLRKACITIVEWRPFEWLILLMICANCIALAVYQPYPAQDSDTKNIILVSLWSYELFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV21</accession>
    <name>A0A183HV21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNF2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11334</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016269">
        <property type="protein sequence ID" value="VDO75727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV21"/>
    <dbReference type="STRING" id="387005.A0A183HV21"/>
    <dbReference type="WBParaSite" id="OFLC_0001133301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001133301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001133301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001133301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13744" checksum="11EE53F506B9FA6E" modified="2016-09-07" version="1">MWGRRNKLKRVFSGGICQIFDLKYRIRFANCLNLHEHQIHGVKRILQWHNEKHGGIIADEMGLGKTCQVVGSIVCLLNDNKAGRHMIVCPLSVLQHWQNELLRLILMFKLLSYFIYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV84</accession>
    <name>A0A183HV84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11395</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016404">
        <property type="protein sequence ID" value="VDO76104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV84"/>
    <dbReference type="WBParaSite" id="OFLC_0001139601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001139601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001139601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001139601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3950" checksum="98ABA807CF6BCAFE" modified="2016-09-07" version="1">MKDQNQKNQNLLNGLIHLHIPLILHGMVMEHCIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV94</accession>
    <name>A0A183HV94_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11405</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016430">
        <property type="protein sequence ID" value="VDO76172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV94"/>
    <dbReference type="STRING" id="387005.A0A183HV94"/>
    <dbReference type="WBParaSite" id="OFLC_0001140601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001140601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001140601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552649" description="E3 ubiquitin-protein ligase PPP1R11" evidence="4">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO76172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001140601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10743" checksum="6F074F546C0A68A9" modified="2016-09-07" version="1">MISSKMFLIMLKIIFLCSVRWSADTVDNEFLGRYKSKCCCIYKKSKKWDENSDSDSDSVRSFQDCETDHCRGHVEKRFRPLGSDGGGESGPSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVU5</accession>
    <name>A0A183HVU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016976">
        <property type="protein sequence ID" value="VDO77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVU5"/>
    <dbReference type="STRING" id="387005.A0A183HVU5"/>
    <dbReference type="WBParaSite" id="OFLC_0001160701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001160701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001160701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001160701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7296" checksum="D812F6F57A4822D8" modified="2016-09-07" version="1">MISAECSSAAGGKSKISDSVCQSTAGMEGDSTGHQLSNVKLKFLDDSQIIAYTALESTVGQFKRFCLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWR9</accession>
    <name>A0A183HWR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11935</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017887">
        <property type="protein sequence ID" value="VDO80540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWR9"/>
    <dbReference type="WBParaSite" id="OFLC_0001193101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7123" checksum="B050E18ECA6724CA" modified="2016-09-07" version="1">MGLLLLLNKQQLYDVIDDEEFRDDQNFLKRTKISAALTRSELVFVAKKLEEGCVLRMFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWS1</accession>
    <name>A0A183HWS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017876">
        <property type="protein sequence ID" value="VDO80499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWS1"/>
    <dbReference type="STRING" id="387005.A0A183HWS1"/>
    <dbReference type="WBParaSite" id="OFLC_0001193301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8395" checksum="C4D8572C2195C78B" modified="2016-09-07" version="1">MDTIASNHAMIHGFLNFQHNRRNISPTQKHIHRNVNRGSRSISLSDRRGFITAPRFPARRSSISPLPHHKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX74</accession>
    <name>A0A183HX74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12086</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018305">
        <property type="protein sequence ID" value="VDO81779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX74"/>
    <dbReference type="STRING" id="387005.A0A183HX74"/>
    <dbReference type="WBParaSite" id="OFLC_0001208601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001208601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001208601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001208601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26647" checksum="92399A632DE3BE5F" modified="2016-09-07" version="1">MVQMNNTECEEGRDNALSIDLLPKIRPKSYSFMSSKDVIFKKNIKCAKEEIGKDSEISKSISFGKTSSLANLSNRPKTSSFLRDLRKLFSRSKTSINASTITTTTTSTLTREIKSQDSIIMRNGMENLNNFDIELREKSRSRSWSHYETQGIFHKNRKPVESKPVGKRIYSSIRALRKNKSVELMNEVVTEDTENKSSIHSKVIIHLSCKHYFYFFINIQKYIKQKKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYM2</accession>
    <name>A0A183HYM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039875">
        <property type="protein sequence ID" value="VDP11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYM2"/>
    <dbReference type="WBParaSite" id="OFLC_0001258501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001258501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001258501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001258501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9793" checksum="5C4926274DE690E8" modified="2016-09-07" version="1">MHNFRVMQQWNSNKTIKAEKQPPLLTCPQGCERISKFWLSCSFVSLLLSGLLTAIIAINKLEQDRKDRNFASIEKAGEIDKDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYS2</accession>
    <name>A0A183HYS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039888">
        <property type="protein sequence ID" value="VDP11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYS2"/>
    <dbReference type="STRING" id="387005.A0A183HYS2"/>
    <dbReference type="WBParaSite" id="OFLC_0001263501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001263501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001263501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF34">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001263501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27311" checksum="4116F76596591851" modified="2016-09-07" version="1">MLLICLQIEDNRLENNIDLDLRSNNFRSTRGQISRKELRLFIRFFVVSLVFLLIWTTWQWLPYISESKWAYFIITSLFFINNSINPTVYLLFNTQVSFSNLRHEISRLLCNSSTKTVPPTHRGYLLTSNKLFKYTTKNQSARISGSSNQHDGRCEASATQSEHNLLTIKISDTINNININKAAVNSAAALVTMTMTNDIDTVDNNDVTNVTVVFKKTHRHLFVDNNIIIIGKNDTCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1P2</accession>
    <name>A0A183I1P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type II toxin-antitoxin system HicA family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13654</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040318">
        <property type="protein sequence ID" value="VDP14311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1P2"/>
    <dbReference type="STRING" id="387005.A0A183I1P2"/>
    <dbReference type="WBParaSite" id="OFLC_0001365501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001365501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001365501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001365501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8178" checksum="3258ED95C83C3B70" modified="2016-09-07" version="1">MALQVRRSASAIQFLIDHGVDLSDINLCGGHSVMRVHWIPQPKDGKPVAVGFSIIKALKEELRNHEKEHPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2S9</accession>
    <name>A0A183I2S9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transcription factor Y subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CAAT box DNA-binding protein subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nuclear transcription factor Y subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14041</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040555">
        <property type="protein sequence ID" value="VDP15346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2S9"/>
    <dbReference type="STRING" id="387005.A0A183I2S9"/>
    <dbReference type="WBParaSite" id="OFLC_0001404901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001404901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001404901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000099">
        <property type="entry name" value="nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP15346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001404901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43550" checksum="46E2D9774987DE9A" modified="2016-09-07" version="1">MINEDDGNNYLDKYSQESDTCQAEGSTTEDNNAERILTVANIASEENSMARKPILEQDRFLPIANISRLMKNMIPRSGKVAKDAKECVQECVSEFISFITSEACDRCLNASEKRKTITGEDIIGAFSTLGFDNYVGPLSAYVRKFREAFRTERSNETLLVEPSGSHPSFLEKINVRDSNESASSSDVFAIQTEPMASSSTCTPQIIFAGEDDPDGAIRVMSTGNVQHLQLLMDPATGQHYINVQNPNGTQQLLPVQVTTVADSSATPLTLPCADVQNLTDGKAIDKEMFNFSKIEFRNSLPKSDNIASTSYKELSCSIKCSFLNLGFPLNIFSNGSTYGLKHSSVGLSTANQHKQQVPYAGNMGQFGHHSNSGDTSGGIREQPRKRSHDSIDYISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I317</accession>
    <name>A0A183I317_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040614">
        <property type="protein sequence ID" value="VDP15590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I317"/>
    <dbReference type="WBParaSite" id="OFLC_0001413701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001413701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001413701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001413701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13542" checksum="72370E7143077530" modified="2016-09-07" version="1">MSSKPLGFGNRHIDPDPADVRNKLSLAASMKPTPVSDDLPTAKEVERIVETQEGTIRQQPLKIASKRKSKGIVQPLNMRVRLATHNRFVELSKTLRMPYDETLEWVLERAGVDEDGNPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3B8</accession>
    <name>A0A183I3B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SERTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IER family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040691">
        <property type="protein sequence ID" value="VDP16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3B8"/>
    <dbReference type="WBParaSite" id="OFLC_0001423801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001423801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001423801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008653">
        <property type="entry name" value="IER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15895">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05760">
        <property type="entry name" value="IER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001423801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40127" checksum="A625FDF73750A017" modified="2016-09-07" version="1">MPPVGDVDEIIETEVCNRLIRLSCAKMVNSKSERGGAKLHRNLLILHLLRRARDEQKRFPMFANDSECMDKPQLAENSMMMLHTNSMPALDTLSPSHYVDVDDEDDEMDDIEYENADEDATHLLDLSKNHEPMPLDSCSGNLVKQEQIEFGYSTLRLAPFQYTFTGAEIYGMDETTTQQHMYNDSASLPEIYFSEDMISSQLVSQQAREKKEVEEFATQKPKRGSDFDCLAVSADTVVAPISESISNDEEVYSCIGTEEDGEIEEDRDCENGSLASTTFLHHRKRKTSALRLPSSCSIKKCCVEERQLTGLISVFNSGLSVVADQFLARPAVSSVSSLQQTPKQINSFIHIACNPLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3G5</accession>
    <name>A0A183I3G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040732">
        <property type="protein sequence ID" value="VDP16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3G5"/>
    <dbReference type="STRING" id="387005.A0A183I3G5"/>
    <dbReference type="WBParaSite" id="OFLC_0001428501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001428501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001428501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 3 N-terminal TPR repeats" evidence="2">
        <location>
            <begin position="39"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001428501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41948" checksum="BD46BF7C89E4B306" modified="2016-09-07" version="1">MVSKMEIDEQKENVNDEKEESGDAKGDEKDDTSKMEDPDAAIVESLRAWCSQLERGELHVLPRMIQLLHKTRKQLNGNVLKKLIASQLTALPLIKDQLISWLPATPSISGLVQPMEVDVSKGGRSPRPVRRSGIQSSVAPPPEVELYIHLLVLLYLVDQKKLEEAEKCVETLIARIDHHEKRSLDSIAAKAFFYLCLIYETKNKLDQLRAYLNGRLRTATLRRQYDSQAVLIVCLLRAYMLGKHYEAAAMLVAKVTFPEAASNNDLARFLYYQGRIKAMQLDYTAAAGYFMQAIRKAPQDAAIGFKQNVQKWIVVISLLQGEIPERSVFRVPIHRKTLAPYLELTQGDFSALAWVWSGCDPKYILNFNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Q8</accession>
    <name>A0A183I3Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPXV012 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040798">
        <property type="protein sequence ID" value="VDP16742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0001437801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001437801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001437801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001437801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4538" checksum="9AB9FC2ECEC4052B" modified="2016-09-07" version="1">MGSNGVYSMIISFIIIIITVMDRYCSSHATNSSSMVHNNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Y1</accession>
    <name>A0A183I3Y1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heterochromatin protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14443</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040861">
        <property type="protein sequence ID" value="VDP17066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Y1"/>
    <dbReference type="STRING" id="387005.A0A183I3Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0001445101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001445101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001445101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18631">
        <property type="entry name" value="CD_HP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000007">
        <property type="entry name" value="Chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP17066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001445101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26545" checksum="57CB87503BE6D896" modified="2016-09-07" version="1">MENRDFFQDQEYVVEKIIDKRIRNGVTEYYLSWKGFPSSENTWEPEENLDCPDLIQAFEVQEKRTKEQKRAKSLERLGRGFFDREKRTKEQKRAKSLERLGRDFFDRGLEPERIIGATNSSGELELLIKWKGNDMANLIPAKIANEKCPQIVIKFYEEHFQWNNCAQVGELELLIKWQGTDMANLIPAKIANEKCPQIVIKFYEEHFEWNNCAQKYTAQDIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5Q0</accession>
    <name>A0A183I5Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15062</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041553">
        <property type="protein sequence ID" value="VDP20225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0001507301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001507301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001507301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001507301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11426" checksum="1C69E41B0DFBE89B" modified="2016-09-07" version="1">MLNRPRSSLLPDHGSVILFSGCFFDKRGRKLRIRKRIQTRGKVIKKLRWDGQGEKSGNEKKPNIEKTEMGGMEEAGEEKWGRGRGLKGKALEHRLHYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5T6</accession>
    <name>A0A183I5T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15098</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041608">
        <property type="protein sequence ID" value="VDP20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5T6"/>
    <dbReference type="STRING" id="387005.A0A183I5T6"/>
    <dbReference type="WBParaSite" id="OFLC_0001510901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001510901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001510901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001510901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21511" checksum="4D24E37D971A8B06" modified="2016-09-07" version="1">MAVVKLKAQKIPGNVNRKAQTAFTSATKNQVHAQKALNQRNQRQVSEKKINYDLYKTTLCRSWIDGIRCRLGERCLLNSNVRFAHGPHELRIARFVYPGSHRYDYEVRMNSSNTSSSSCRRNSKKWFATQHDASNGNSNVECASTNNSPEVTGKHISWWADTISDAYPFINRPSRNIQPDHNAAQSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I619</accession>
    <name>A0A183I619_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041728">
        <property type="protein sequence ID" value="VDP20740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I619"/>
    <dbReference type="STRING" id="387005.A0A183I619"/>
    <dbReference type="WBParaSite" id="OFLC_0001519201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001519201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001519201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001519201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31210" checksum="95B659107B002296" modified="2016-09-07" version="1">MNELIGLRFVLKMPIKIMAKLDRESAVYIAGEAIQCKVIVQNIGNDEESLAWGTVHVQCERIVRANKPDVTLARKNSASEKSKGTGTTAMSRSAFTVFSCRPVILFCELILNAGENRDFECTQQLPLNSIPPSFKGHLVRYVYKLTLGVQHVKSPIKLIHVPLRIIQSDLGLTLPSSPTLVNPFISNHNVGPSIVDLAMEAVDCLTAPRGAYTYSITNSSGRVASFSLNKKAYKLGEDVIGKFNFDNCTVRCLQVYSFTFCYQMRENIEDMFDIILFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I636</accession>
    <name>A0A183I636_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15198</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041750">
        <property type="protein sequence ID" value="VDP20794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I636"/>
    <dbReference type="STRING" id="387005.A0A183I636"/>
    <dbReference type="WBParaSite" id="OFLC_0001520901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001520901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001520901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP20794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001520901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21585" checksum="3C0414D7A90A0360" modified="2016-09-07" version="1">MMNGLSLSNETSLQGGKEIVKLYKYDRNEKLPAAVDWRKKGLVTSIKDQGECGSCYAFTAAAALEGYYKKKKGKLIDLSPQNIIDCSRKYGNKGCEGGNMLSSFEYAKDYGIAEESKYPYVETEQPCKWQEKIGIVTVKGYVLVPQSDELALKHAVAKLGPGDELALKHAVAKHGPVAAAVHSLLPDFKNYKSVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6G7</accession>
    <name>A0A183I6G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15329</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041965">
        <property type="protein sequence ID" value="VDP21357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6G7"/>
    <dbReference type="STRING" id="387005.A0A183I6G7"/>
    <dbReference type="WBParaSite" id="OFLC_0001534001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001534001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001534001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001534001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22855" checksum="33FC68C13121913C" modified="2016-09-07" version="1">MEWCIRFKYQLDSEEGLAVQLIAQYLSQVEGTLYKAIRGNGLAYGVNIEINVDDQLLSFSIHQSAQLEQAYEEAKRVVLKELEHVDEIEFEAAKRSLVSVIVQSEDTVINAAHQAVFNEFRELPPQFWRKYSERIWNASMKEVVECSRNFILDLFDDRKCYRAIAVPHGKLKDIEKYFVGIEVVCSSDLHIKDTSITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7W2</accession>
    <name>A0A183I7W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3453 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15822</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042965">
        <property type="protein sequence ID" value="VDP24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7W2"/>
    <dbReference type="STRING" id="387005.A0A183I7W2"/>
    <dbReference type="WBParaSite" id="OFLC_0001583701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001583701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001583701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001583701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25284" checksum="A1320B808E352275" modified="2016-09-07" version="1">MAHTLRALTHLRMGVRIYALTILTLLMRTYPDLCRNSIDLFDSFVEFLNSKRIPANRKLLLDAVHAFLRAFLVEECARVGPLHVASFSIRTKQCTRINLIPTTAPLIDFCVLGSQPQQSKSSLYLSDKFLPALSGILSLFLMSASEDESSCNEKEWVDIFGMLNKALLQIRASSQTVQFEEELKKTLSGINSLLKNGNLSARIHTSLQKLNLPNKRPVGKVKNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7X7</accession>
    <name>A0A183I7X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15839</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043022">
        <property type="protein sequence ID" value="VDP24203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7X7"/>
    <dbReference type="STRING" id="387005.A0A183I7X7"/>
    <dbReference type="WBParaSite" id="OFLC_0001585201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001585201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001585201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF125">
        <property type="entry name" value="PROTEIN MALE ABNORMAL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP24203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001585201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20074" checksum="A1FEE5941219FDF9" modified="2016-09-07" version="1">MVEERRRLNNMLSLRRLDPNHVTNRSTTGKKIRDPKCALCSAHGNKQPLRGHKKAQCPFLKCGCHLCGLVENRRTLMARQIKLRRDQQKQRKAQLNAANAAATFAATTNVATNNSIMEQSNSEIEQEQFTVLNNNTKMEEPVRVPPFLPVIPKPQIMESRASVPVIFQPTPIIPTAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I824</accession>
    <name>A0A183I824_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15885</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043136">
        <property type="protein sequence ID" value="VDP24554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I824"/>
    <dbReference type="STRING" id="387005.A0A183I824"/>
    <dbReference type="WBParaSite" id="OFLC_0001589901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001589901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001589901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001589901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15310" checksum="88587BF68419859A" modified="2016-09-07" version="1">MFYLFQVARYNSVAQHQTIQHSISSPLLKCRTEVLRIMELLSEKEYTNVTDLMIPVGEILVHCLDASLLKHKSLSEIFPPITRYVIFHTLQAHKGAVTAVAFSEDGKFLATYGAEEAKLSFWQTSQTFLVSPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I834</accession>
    <name>A0A183I834_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15896</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043166">
        <property type="protein sequence ID" value="VDP24658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I834"/>
    <dbReference type="STRING" id="387005.A0A183I834"/>
    <dbReference type="WBParaSite" id="OFLC_0001590901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001590901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001590901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001590901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10682" checksum="861CE887E2BAB0FF" modified="2016-09-07" version="1">MKEHPDYKYRPRRKPKSITKTKEKYRFTLPFTAFPATNLLSQQTVPRAAPFYPSINPLDMAAKIAADSAALSKATEFSYYPPFFHPTAPANTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8M0</accession>
    <name>A0A183I8M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16082</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043986">
        <property type="protein sequence ID" value="VDP26947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8M0"/>
    <dbReference type="WBParaSite" id="OFLC_0001609501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001609501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001609501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001609501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4121" checksum="1CF21156655B88AE" modified="2016-09-07" version="1">MMANVFGASAPQYQDDSSAEESMIDRKGPLTIPHQIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TUA1</accession>
    <name>A0A3P7TUA1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000177">
        <property type="protein sequence ID" value="VDO26070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7TUA1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF68">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="795" mass="91981" checksum="64AAA8499539A7FC" modified="2019-02-13" version="1">MFKSCSHISVRLPTKIPSHASSVCTPYVQDDARSFIYSDAPSQALTYKSVPALRRTLKKSSSIINTILAFSIRSTYHYLTRPCNRHLDSLHAIRVLSAFWVVIGHAHLFSLEYVGNIRQFWSSLKTNEHLFQIIFNSSLSIDSFLLISGTVLAYKVHLRLIQLKRRKNGRPALSPCGWLLLWLHRLMRLTPAYFITLLIIHFIFHHLGDGPMWSQQNGIFGARCDKDDIWRQLLFVSNFYPNECMPWMWYLALDTQFYLVAPIALLLMHTEPTIGTVLIVISIISSIIYRATVVILFRFPTTFVSAFIGNDGLATQLMEKMFRYLYAAPQARIGPFLIGILLGWLLSTKSKQTHSTAQIDITRFASFAMLFFSLFGANYANDFNTFSIFYAATFRIFWAFGLALLVWLCERGYMRMLYSCLAWNKWTFFSRLSYGFYLSHEPVLLYFIWTRRSAIMPLSPYYFIIFALKMSLLSLLPASLIAFIIEIPPLIIERKIFKTIRARVASNDADEETKQNDTEHKSNLQLFHQRNNDEIIELVPMISPINRTKRWIEENHKNLRTGSKRPHNAVIKNNRTRHHRIGTSKTDIFCKGIKKSAGIVGSDIVSTCKSFSKESAGRKQLIKNKPFCTPKSSTKMISKRRQLRNFVDDTRNIAHKSDIITKKKYCKAPEVDGLMKKKQKMSIKQNYDKEEINYTDPKMPVTTHHHIQVSMMENIGFSWVEEIAKNFDADAERTTHSQVPYNKKRRMTQYIDSNQQQQQDFDDFNLFAKQKSLSNKSSNSTITGETTWQIISNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VGB2</accession>
    <name>A0A3P7VGB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001675">
        <property type="protein sequence ID" value="VDO34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="132" mass="14895" checksum="26AE5EE50828CD04" modified="2026-01-28" version="1">MQYQFAIDLHTSGTGRQRGSWLWRPRKRVLWPGVRVGKLAGREGRIAWIIMIWLKGGRNKSNGEGLLGEEQRGNRVARGRFRWCTPTDPSPSHQNTSYPCGQHSRYVSNSKSSHSSRAFPFAIISITLSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VJL3</accession>
    <name>A0A3P7VJL3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hflx-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001139">
        <property type="protein sequence ID" value="VDO31863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VJL3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000886">
        <property type="entry name" value="Putative GTP-binding protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="5">
        <location>
            <begin position="161"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="521" mass="59847" checksum="B56D61B76653B899" modified="2019-02-13" version="1">MYRFRTTAISTDCSTKKKRLWGKGRLERIIALYEKINATALMIDVDILSPKQQTELTSMFRIPVYDRYNIVLLIFKMFAKTKEAKLQIELAEIPYIRQRLLSMYELRANPSTFHLDTSDKSKAERLEVLRYREQHLRKCLKAAVEEKVNLRIGEAQKNIRIVVAVVGYTNAGKSSLIKRLTGRDLYVEDRLFATLDTSLHVFRLPSGLSILFADTIGFISNLPTQLLASFQATLNHVANADLLLHVEDVSNPDYLTQRDVVMKTLSLLKIRSELLNSIIRVGNKIDKLNQLPPDEPNTYFVSCANGRGLVELMAAVDKKVLTISGKTIRRLKLRPHSEAFSYLCKYSFLVGQPVPSEDNNYLLCNVIMDDNEFSKFRAHFSPIIALQFKANMVNLKCTNCGEEPEHWQYEKFNMPGSRGTANILEKCKLCSRVNSLEIVKDSFRSYKNNDDYDELIRFDCRGLEPTDFDPKSGWRAIGTESATVFENIDLTEKEWVDYDEEAAQPTEINEIQCRFVLCRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WJN5</accession>
    <name>A0A3P7WJN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011805">
        <property type="protein sequence ID" value="VDO61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WJN5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO61311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="455" mass="53683" checksum="5515811BC1028404" modified="2019-02-13" version="1">MNLGEKQSTVIIDNTEQNLVAFRRNIYLTIQSSLDFQEAAHKLLKIDLKSGQDVELCNMIVDCCAQQRTYEKFYGLLAERFCRLRKEFQEAFERIARDTYNTIHRFEYNKLRNMACLVAHLLSTDAISWNILDQISLNEEDTTSSGRIYIKIVFQELAEFLGVENLLQRIRDPTMQSSFDKIFPRDNPNNTRFSINFFTTIGLGYLTVDLRLHLDQARKKARAKEDSLSSESSLSDSDSDESSSDSTSSTSSSKTDGDDNNEKLKHNMKALQKGEQIKNAPKTVKKENYSLKDTGRENEYDWKNGSHGRESEVAERYGNDRKKMKRRSFDKESDRKMGKKYEEKRKDNKVDEPNVKKHKKSTIEREDNEERRNERKKHDRTEHKVNKMEERKCDEKQKRRRRDSNDMENREKHSNNEESDQDDRRGRMISKQEQQKGKRLVATMNKRESKRRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X5H0</accession>
    <name>A0A3P7X5H0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011795">
        <property type="protein sequence ID" value="VDO61289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X5H0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF131">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14629" checksum="B2B5F999C19FBB00" modified="2019-02-13" version="1">MFSQGRLAYTNLGFNREALPQGNQEKDCRSHPQYPCFNAGDERNNEQPGLTVMQTIFLREHNRIAISLSNINGHWFDEKIYLETRRIMGAKLQHIIYNEWLPIVLGSEATAKYDLVPRKTGYYHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XB17</accession>
    <name>A0A3P7XB17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000238">
        <property type="protein sequence ID" value="VDO26592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZJ4"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="248" mass="28802" checksum="2D783691E2DE3878" modified="2026-01-28" version="1">MKLNIAYPTTGCQKVFEIDDEKKLRIFYEKRMAQEVEADALGDEWKGYILRITGGNDKQGFPMKQGVLTNGRVRLLLSKGHSCYRSRRDGERRRKSVRGCIVDANLSALALIIVKKGEQEIPGLTDTTVPRRLGPKRASKIRKLFNLTKNDDVRKYVIRRKLPEKEGKKPRSKAPKIQRLITPVVLQRKRRRLAMKIKRSVKRREEEAQYHKMMTQYAKEKQAAKIARRRSSASRRESESARHSKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y7H8</accession>
    <name>A0A3P7Y7H8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018747">
        <property type="protein sequence ID" value="VDO83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y7H8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF5">
        <property type="entry name" value="CELL JUNCTION PROTEIN VAB-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15171" checksum="EFF6A7BC4C6DFA85" modified="2019-02-13" version="1">MNSISAYIKLVATLLITAAVFTFIAFFLNVFGLRSRDLHWKYIFYKFATYISLFGVFLELISLIVFPVCFYVEMKNFGYRNWEFDWSYGVAWGATLFSFSASLSLICDKEHEEVYFKEKTIYNPPPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y9Y8</accession>
    <name>A0A3P7Y9Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001620">
        <property type="protein sequence ID" value="VDO33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H5E9"/>
    <dbReference type="OrthoDB" id="5856682at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="571" mass="65057" checksum="D3031C5B0E9DB350" modified="2026-01-28" version="1">MVRTYTWNPSTQSSLAITGNFNNEDKKTITNSFSTTSTNLYSTQCFSNGPIYRPNYKNGQITNISTAIPKDDTKNDIASTSSEGLSTGSGSSHIQCPVHMLQSQTSPFWQSHHQPFSVYYPIAVDFSTNLHHWRPHLFSSQIIAPIMLEQRSIDLWHLRPIQIGNKIYYEPMSSSSARHSSPTSIKPQSVTSANLVANPNNARFQNVNLPHLPNATIPVPPNNISGKSKLIHSEAAGINHSKTSRYDSFSNNGSIDLPWIFGTSQPKSGIRGTPSWQTPLLVTREDLVFNREVNETSTVSTLQKSQCQTSPSHQLHGSLYQHSLPHKIISSLQQQCCRKVTAIDSTEQYKRDLQLQIEENRRRKEEQRQRELEVERKEMIKFEEYRRKVQQEIEEEERKEKGKILAAQHRAARMRALQEEAALKARREAKNRTRRNVRCNSENVRTMEGRKSSVVEPNRLEWWEKKKEHVNASRLAYSPVIPTLRKKNEISANPSRNTAFEILENDTSVPNCAPSDPSKKWHSSSRLSRRCYNSSLTEGRNNSLDSAGSHQKSSHSEEEEKQNESLLNSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YSI2</accession>
    <name>A0A3P7YSI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004418">
        <property type="protein sequence ID" value="VDO42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="90" mass="10714" checksum="D1D415CF2C76ECA5" modified="2026-01-28" version="1">MYSVHRLHEHFTSRLITCDIFVCCCMTSTKTDEDPFSRRHRKVASAYLHNTGSTVKSINQFSRYHPESSYRVHHHDYLCQPELNEQTRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AXP8</accession>
    <name>A0A3P8AXP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041343">
        <property type="protein sequence ID" value="VDP19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AXP8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="271" mass="28814" checksum="2CC004807D1B4A03" modified="2019-02-13" version="1">MKRREAQANHLPVPVLSASTVGTLQSLVSTQFSFIASSPSPMMKPSAVYSASSGPISVSRKKPGRPARTFQQQTAGLPVGLRTNNVTAEISSQEREPKHEMNSPLSKASAHQRQVQNSVHVSTAGVRPAISAPPQGTPQKSSEQSAQASVARKRGRQPGSKNKPKTDTTQPGAPIADAPTRQSGSKRVREDYDFDSEDERTAEPMSYDEKRQLSLDINKLPAQNGARTEQTTTGKGGEPSSSESSSSEDDSSSDSSSSDSSDSESGTLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B5V5</accession>
    <name>A0A3P8B5V5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013512">
        <property type="protein sequence ID" value="VDO67212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B5V5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO67212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="102" mass="11588" checksum="1ACF510978DDD767" modified="2019-02-13" version="1">MTYCKNGFWIPPVGICQPITETRIIDSCKPLNFPSNGKVYYIYNNYTKDYQVGTTAVLVCNKGFRLEGEATLICDENGWTPHDGFGNCVSADDNFRNFHKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EUZ6</accession>
    <name>A0A3P8EUZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040645">
        <property type="protein sequence ID" value="VDP15789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5802415at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="278" mass="31745" checksum="E93557B645C578B3" modified="2026-01-28" version="1">MPSISALSPYSYKSFHPLKNDDKDSGSSGSEYPTSACYADEEQFTQSLFRLVLQSQTAYAQYMKLVALFVFAVVHIMYMIPFLNTFAAVVCSVDMTDVMLNVESYHLRHFIETLIDYKKNMWMIVGSMCVALSTSCFILMLNASSRKVAYDIVIRGIDLLTFGTLPFFLFARLILLDSISEQLPIALYEIQFAQYSEQLSAALHCSFVPIKEVSLCDQVIRNTLFPTYIIKFLIILAILTIAYMLLAYLIEWCLRHWFPPQCNHSKHASIYTPISMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FAK3</accession>
    <name>A0A3P8FAK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040756">
        <property type="protein sequence ID" value="VDP16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I3J9"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="371" mass="41446" checksum="53C319CFE8909B6A" modified="2026-01-28" version="1">MGQHLSLKRRRNMSADAATSTTSAVSTTATAGAVNDIESPKPGDKTTVVSNPRIEATDDDDTIDEPPKIQQGNRRRLAVSAEVPDENEAANYDKVVIPKDDETRRALEAAMCKNILFSHLEGDEQKAIFDAMFPVEKKKGETIIEQGEEGDNFYVIDSGEVDVFVNGEYALSIKEGGSFGELALIYGTPRAATVVAKSDVVKCWAIDRITYRQILMGSTMRKRKLYDEFLSKVQILSDLDKWERANVADALERCDFEPGTHVVEQGHPGDEFFIIVEGQADVLQKRSDDAPFEIVGHLSSSDYFGKFLKFYFEICEIALLLDRPRAATVIAKTPLKCVKLDRARFERVMGPVREILKRDVSNYNSYVKLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXS9</accession>
    <name>A0A183GXS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS39</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000009">
        <property type="protein sequence ID" value="VDO24304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXS9"/>
    <dbReference type="STRING" id="387005.A0A183GXS9"/>
    <dbReference type="WBParaSite" id="OFLC_0000003801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000003801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000003801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000003801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27844" checksum="37BB10E0538C2A95" modified="2016-09-07" version="1">MAHNSKLTIVFIGSAQKEALLEKIKSTAMRCEKHIIYQDTHYLTYLVDGSEAIVELIDPGLEHTGARQMSIRKAHGVILFYKASSQSSINQLCDMAPDFQTIENKVKVYQCIQEFCQQIPPILLIANEDIDERSSEPTYASTSQKYKSNSFPLMVEGAAMIKPSSDLTKLQSQNAADLFGTYCKSLSITIPNYDETLKFMEEMIRTIRLQQEQQENSSLQWLSKIKDKKNARKTKAKISSKICSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZL5</accession>
    <name>A0A183GZL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS675</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000246">
        <property type="protein sequence ID" value="VDO26663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZL5"/>
    <dbReference type="STRING" id="387005.A0A183GZL5"/>
    <dbReference type="WBParaSite" id="OFLC_0000067401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000067401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000067401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="186"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="286"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="846"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO26663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000067401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="888" mass="102351" checksum="DD7A4475B573165E" modified="2016-09-07" version="1">MLNNAETLALHAVYYYLIIGSMKECQLLANAVRKSLVEIRIQPFIQRKEMFMEKIRAAGQETSAEQIADWNSTIIELERLIAYHKNLPEKEVLMNDYSEVDWAKIAKVDFLGNRTPKQLRLKWINEQCPRWSKEPWSSHEIQCLKDCAGRWNNWNVISERLGTNRTAFQCFVKFRSELDIDNVGRSWTKEEDAQLMTLSHCMQVNGKMNWEKIAHHMEERSRQQCTIRYRRALDTDIKFGRWDASEDVLLTCSVSRFGTKDWIKVASCVPGRSDSQCRDRWVNVLDKSIKAEPWSVDEDEKLIEGVKIFGKGEWSRISTMLPGRSASHCKSRFRSLLTAKVKLASKCRTYPLRRFSWKGKRRRQEVEATFRKLLAADGKGSLAEQVMNSFDMRALSVDEMEALSAMAPEHRIIVMQFLNEVREKRFENEMKDDQSVWELLSDKLQFNTSYLDSSTQNALLKYYKKFLGGSAHELLSRHEKNEFDTKCKVLQETDSEAAKNLVINGLCDLIERSDNSQCCIHQKKLPRSQVLDEVGRYLNSVLIGDVNKAVSYGTKAFALPPCTGSLHLYENIQQQIHLLRESAGEFFEPLVSDQNGSIFLQLSRQITLDPEYVLFKSKLRTLLFWPMLLYRSIESKDSLEERMYLRSVAAMKLSEQQKQALESLKERLQSQLRSDANAPISKQIMVPENDFDDDYTAELSVGEFLKQRMYKRPRRHITDKKKGEEDSHQKGVLESDPSEITELMSHRIDECIESVCMAVQKIYERDFVIPAANRLAAQQLSKNNPNTNIMEEAVKDALDSVIDEIASGGVSETVNLLPKMKRRSKNVVDDNNSQRNDIVSKIQQPESTVRGTDGRKRKVTDIAQSSSGEVDKPKRARKRTGAKLLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0G1</accession>
    <name>A0A183H0G1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS971</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="UZAJ01000402">
        <property type="protein sequence ID" value="VDO27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0G1"/>
    <dbReference type="STRING" id="387005.A0A183H0G1"/>
    <dbReference type="WBParaSite" id="OFLC_0000097001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000097001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000097001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF897">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="100"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO27750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000097001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62225" checksum="215AF7A83519C84F" modified="2016-09-07" version="1">MIVYETILYVAVAAMNDLHDLKYFDRRKADSETFLMPSDFAMASELGDNDWQNNDDWALYSSGKFEGDMDISEGDILELANTYPNVNSDDTYPQNNVLYNAVRNRHQLWPNSRIPYAMSNQYSPYSRSVIAAAMEEYTQHTCIRWVPRSVEDYDYIYIVPDRGCYSMVGGKQTVSLGTGCIQKGIIMHELMHAVGFFHEQSRTDRDNHITVLWGNIQPGMQVTLKCVFQFHSFNHSFMRVPVQHFPPMLGIFTGQFEKYEHGIIDSLGADYDYDSIMHYGPRAFSGNGQPTLVPKIPIAIGQRLHFSTLDIFKINELYNCPLLLIVPGVTGTKRIAISPSPKINESQKLTNASIHLIITDSCKNIRSDCDELAVHGWCIGNPRWMKHYCPKSCKLCSNLTLQPCVDQRPDCFTLMQNGHCTISNAFMHAFCSKSCDFCKSVEVLRNETVTTTLLSTKSAIITTIETTTSKSNRLKQSFGSAWRKLINSRINPTEVFSTQKTCIDRKRFCIHWKNVGFCKGLFSNFMMENCQRSCKICTNEDDKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Z9</accession>
    <name>A0A183H0Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VEFS-Box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000506">
        <property type="protein sequence ID" value="VDO28467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Z9"/>
    <dbReference type="WBParaSite" id="OFLC_0000115801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000115801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000115801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000115801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61169" checksum="C1BA12275D6A44AC" modified="2016-09-07" version="1">MDGERAQKFDASALVSKRNVHATQHENRGDTLRNDCLNGVAWGMILFTRMVVRWTYVYLLVAECVVIQRATMSPEKGNTRCQIEPRRTETRSTTAADLKSSPSGCKTYASTSPYKTRQQSNGIATEKTRYTPDFAPVRSRRGSSAVVISPLQAVPSTAATKKKGRRGRDDNSDDDTASSSSGPVNAKRIRLCYNKNDIKNVEIVDDIVPEIEEIMQQNNMIEDTSHDALTERHPQKKIDSDLEQHFKKAIRLYRYMSLPDTQVGSARPVYRPFLKRNLIYMRRSSQSITVVDVCMPPLCPSTTTAGKIGMKAKLRKHEHIMDILHAIRRRNEILKKNAKTKSSSSAAVSYLVRALKQDEDSRKGNGKDALSKETRRHVNCSHPTSMIKFVDVRNKELPGNRHAVITVYLSSEVDGVFSEIMRLPSATVQMQINTRGEPVAIDLPLSIGCPLHCSGKQRNDYVIIRVTFSGEEFAHILGGKSLRSVPSRQTDKGSKTVVHVTRRISCLSSPDKLRNSEGSITMYGARCISSVAKGETSDGLIYGHGSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Y5</accession>
    <name>A0A183H1Y5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Splicing factor 45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA-binding motif protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1495</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000713">
        <property type="protein sequence ID" value="VDO29754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Y5"/>
    <dbReference type="STRING" id="387005.A0A183H1Y5"/>
    <dbReference type="WBParaSite" id="OFLC_0000149401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000149401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000149401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12647">
        <property type="entry name" value="RRM_UHM_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000079">
        <property type="entry name" value="Putative splicing factor 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034653">
        <property type="entry name" value="SPF45_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031066">
        <property type="entry name" value="Splicing_factor_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO29754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000149401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16749" checksum="D2E479531094B6C3" modified="2016-09-07" version="1">MSTALKVERLGKNSGVIVNEHELSARAEASVSPPLELPTVSATPAVNMTEALKQSSRILLLRNMVGPDEIDDQLEPEVKDEMKKYGQVNKVVIFRLLQASDDEAVRIFVEFTNVGQAIKAFVDLNGRFFGGRSIKASFYDLEAYNANQFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H286</accession>
    <name>A0A183H286_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1596</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000782">
        <property type="protein sequence ID" value="VDO30097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H286"/>
    <dbReference type="STRING" id="387005.A0A183H286"/>
    <dbReference type="WBParaSite" id="OFLC_0000159501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000159501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000159501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF185">
        <property type="entry name" value="ANGIOPOIETIN-RELATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552343" evidence="3">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO30097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000159501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38312" checksum="573928B7D88353F9" modified="2016-09-07" version="1">FLILILDLCALQLPGCNQTKISSIIASPFDVDAPVKNLIEGCREGEFQCITSHECISIVDVLDGIEQCNDGSDERYCKDTGNEMCQKPKQCSFNPAICMFTCDCPLGYSRTSSGLCIPSLAPAFSSDCADLQRRYHSVESGLFKLNDWSCSKPELCPFIAHCEMNLFGGGWTIIMQRFNTSLNFDKDLLEYENGFSLDDSNFWIGLERMYRLTNRPQRTNELILRLLTASNGQIITVRYSHFIVYEKSLGYRLNIGSITYGNGMDTTNELAQSQLCPFITSSEKECVGGGGWWRKGCQQKGVLTATNKAQGTYPGLNWNGKRLSAVQMLIRPRGYVPPPKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2S6</accession>
    <name>A0A183H2S6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS1786</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000907">
        <property type="protein sequence ID" value="VDO30778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2S6"/>
    <dbReference type="STRING" id="387005.A0A183H2S6"/>
    <dbReference type="WBParaSite" id="OFLC_0000178501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000178501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000178501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="210"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO30778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000178501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47360" checksum="42263887F27C8E58" modified="2016-09-07" version="1">MAEEIATAVGNIFIDESDHKSQSAKLKALLQSTLSSGINEKDISNNVSRIAEAVVNKETISMVVSRQFVSDIVATLDDLKPNLVKEVARALLNIVQSRLISYEEQVTQLRFRLADLYEEDGDSEEAAKILMAIPLETGQRTYPPELKMRTYLRIAQLALDYKNSEEAESFVNRASMLFSDVSKDDELLVIFKSLYARVLDHRKKFIEAAQRYYDLSLFQNMLTTSEKMQALTNAISCTVLATQGAQRSRMLTTLYKDERCSSLSAYGILQKMYFERLIRNDEVIEFEKSLSSHQRVTRDGWSLLQRAVIEHNFTAVSKIFTNITFEQLAKLLDIDRRQAEKMAWQIIADGRVGGIIDQIDGIVHFTHTVDEDAVPIKEALAEWDQHIAELCQDVNIVTDMIIQKHKLWVDARKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H378</accession>
    <name>A0A183H378_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS1939</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001030">
        <property type="protein sequence ID" value="VDO31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H378"/>
    <dbReference type="STRING" id="387005.A0A183H378"/>
    <dbReference type="WBParaSite" id="OFLC_0000193701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000193701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000193701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000193701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="803" mass="87736" checksum="DD8B5DE01AA97BB0" modified="2016-09-07" version="1">MGGSPSVTRRRVNGPGLDQRVEGLLYITPSTQRTIRWSTPIHQQHLNQNANRYRAAEEDIMQAKDSVMNLDDYAEFEQRGRSHTWPERQLVHSELNAIATTEAADPGLSPRVYTPGLLSNESSTSISATSSASLAEALKSNLNLIPEPDCNQESEPASKMGFSREKQIMVSHPKKIPFRTQSDMRLSAINMDNMKSNAAISYSSVSHFSVQNSSQHVTNALPTLSLSHSSPAQIQSPVVSHSTFNVRQNITPTDNSAQLSILKLVSTAGDTSSLLSVIGSGENFSNSSISSPTHRIIGGSAQNLTVTLVDPHIESSSGPLLTNENNMSIIKSLPCSDSSTTCSASSIPNSCDSSQILTSTVADLDATVPYFTAHADAAQGLIEEDPEDPGEQKPIKRKRSRKRLNGLISQKKSNPWGKESYSDLIAKALRSTFDGRMRLNEIYNWFASNVPYFGSRTSQEQSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPDAKPGRNPRRQRSATLETTTKVAMDKKRRGARKKVMEMRANAGGGTLHSAGSSIVGSQASVLSRELYTGEEDSSNFEPFRSRTQSNLSLSGSSSRVSPSMIENYENFDSFDFPPFVEAASAMPHDILDRTNEMNLNQSDSPAFHRPMANPMLNGTSTPASSNLIAHIKTEPSSSRTESSVQPPPSYHELDVVRGVQNMQNPLLRTHLMQNRIPSQQGIPFNGNFSTGSTNVATPNWMHSNVVPVSIHPSISCAAQQSFSGNTAALPMDLENLALPDQPLMEVENMEAVIRHELSQSAGSQLSFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3J6</accession>
    <name>A0A183H3J6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2056</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001108">
        <property type="protein sequence ID" value="VDO31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3J6"/>
    <dbReference type="WBParaSite" id="OFLC_0000205501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000205501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000205501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000205501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9843" checksum="3D23065BADBACF6E" modified="2016-09-07" version="1">MIVKKNFDMPYSVQRETKISTPFYLLRAALKNQEFTLASNLVHIKAKLLRNTLHFTLIIIYCPKNPTLKLSSGYAKHGDMKASSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Z2</accession>
    <name>A0A183H3Z2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrotransposon protein, putative, unclassified</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001216">
        <property type="protein sequence ID" value="VDO32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Z2"/>
    <dbReference type="WBParaSite" id="OFLC_0000220101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000220101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000220101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000220101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17401" checksum="B29B35553F4BCD2A" modified="2016-09-07" version="1">MRLASSPLRPYFMKQITVRRQSTYPTKIREKSKAIWDDIVKKTDLWKTNNVEGLWGHVPIIYFKHCSCCAMIALNVFFFFSGWKGRNREFLWHAIEDRFDYEYAFAWEPFKEAKPPKLLLMRTLQKEMWAAALKLGTWFLDPQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H556</accession>
    <name>A0A183H556_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001538">
        <property type="protein sequence ID" value="VDO33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H556"/>
    <dbReference type="WBParaSite" id="OFLC_0000261501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000261501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000261501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000261501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22786" checksum="1C8849BB352810BE" modified="2016-09-07" version="1">MESKPIANCGEKLENEERQLSNEKQCGGDAHEIDPMGISADMSKVISAQGDDYDRTHKRLSKPVDLNEDKYTGDEESADSSDSEVKVSKKYRKKKFKGNMNTFNISSGTQSLLQIKDTDSAADRYSYSEKDRNHVEQSVPLTISEENKQVGKRLSVAERSLQQSLNYSGERNHSSSSSVDLSDRNSAGTIRPAYMACANYYYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5K3</accession>
    <name>A0A183H5K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2763</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001665">
        <property type="protein sequence ID" value="VDO34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5K3"/>
    <dbReference type="STRING" id="387005.A0A183H5K3"/>
    <dbReference type="WBParaSite" id="OFLC_0000276201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000276201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000276201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000276201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11927" checksum="7D8756BE1E5AB692" modified="2016-09-07" version="1">MIPFISFQVLSGDDPAVKRGKPAPDPFLVTMDRFKQKPEKAENVLVFEDAANGVCAAIAAGMNVIMVPDLTYMKIPEGLQNKINSVLRSLEDFKPESVGLPAYDSNNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6K6</accession>
    <name>A0A183H6K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3118</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001987">
        <property type="protein sequence ID" value="VDO35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6K6"/>
    <dbReference type="STRING" id="387005.A0A183H6K6"/>
    <dbReference type="WBParaSite" id="OFLC_0000311701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000311701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000311701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0401">Integrin</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="7">
        <location>
            <begin position="132"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000311701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52071" checksum="9D39A73E69C4D1E0" modified="2016-09-07" version="1">QDEDGTYVTQVGEKATIDISFSVRNNGERAYEAMLFIEYNSGELDIPILNKKEGAVNIDDFKSNLAIISLGNPMEPNKQLKFELSFRLARGRTEGLGKPLEFRAFVNSTSDEKNLDDNSWKAVVRVIKRAELELSAISDPAIVRYGGEIKGESEMEFDADIGPLVVHTYTVTNKGPWSVSNVEWPYQVASVFATGKWALYLMEAPTMQLTNTDNSKDIKQCTMILPHEWINPLQLKLLLETENEHYFGEENTDNNIHQEDLQDETNGGLNRVKRTVKEQREKRPSRELRIKSTRVREKSGEEVEIVKVNCVDKTAKCFTVTCHFDFLDVDAAAVIDFRSRLWNATFVEDYYDITYVEISSSGRLILDQEQGIEERNTENNFASASTHAYPDRPAILETAPIPWWVIAVAALLGLFILFILILIFWKCGFFKRNRPHHPTLYQAEYQFRREETSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6P6</accession>
    <name>A0A183H6P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytohesin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002026">
        <property type="protein sequence ID" value="VDO35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6P6"/>
    <dbReference type="STRING" id="387005.A0A183H6P6"/>
    <dbReference type="WBParaSite" id="OFLC_0000315701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000315701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000315701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000315701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10728" checksum="AACDB95C32BD251C" modified="2016-09-07" version="1">MFGFWRKSLYVAPKSPKIICEGNLSDSEEELLSEERKQRSRLQQLHLHIKELRELNLPTKQVEEELWDVQTAITVLCRKVMSYFISYASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H804</accession>
    <name>A0A183H804_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3617</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002482">
        <property type="protein sequence ID" value="VDO37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H804"/>
    <dbReference type="STRING" id="387005.A0A183H804"/>
    <dbReference type="WBParaSite" id="OFLC_0000361501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000361501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000361501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000361501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="37384" checksum="95A27C5E3371C0F4" modified="2016-09-07" version="1">MLKSEANEIKQKKSNISTNNYYQFNKACEIFEQLPVTNFLEIMKQYSNCMNETEQNYQSIQLKELAEFLDEDKEMNVNETKAVLHFLESFSTSGRIDCRKLFVEFEKSRSQLLDVTEQKFINKQMMIPNKHRRSENVQLKLPQEMKLQQLNDSTPKFTSQVSRRAFRVVNNDDRILNYHFILNQSQTVCIMCELLTNNDQPADRNYKNDIYVVLYDTIEEQVITVTMKALEDKYVSEECLLKAGEYIVNIQTSNCLECSNMSSTSYEMELVDSNGKLTKHFKLVYSSHSRKRKRNEKNYAKLLIIKLKIEVFIAMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H877</accession>
    <name>A0A183H877_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3691</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002558">
        <property type="protein sequence ID" value="VDO37441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H877"/>
    <dbReference type="STRING" id="387005.A0A183H877"/>
    <dbReference type="WBParaSite" id="OFLC_0000368801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000368801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000368801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO37441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000368801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17324" checksum="F0A7DC7BD6D8ED4A" modified="2016-09-07" version="1">MTDFGPSSQHFLRNSVQMPWQRAVSSSNHLPYYINHETEVTQWDHPAMIEIMEELTNFNQIKFSAYRTAMKLRSIQKRLCLDLLTLEDVDLKLETLNTMLGEQCLSMKDAVMCLVPLFETAQEKYPELIHSVPLAVDLFINFVLNIFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9R3</accession>
    <name>A0A183H9R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NCD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4224</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003119">
        <property type="protein sequence ID" value="VDO39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9R3"/>
    <dbReference type="STRING" id="387005.A0A183H9R3"/>
    <dbReference type="WBParaSite" id="OFLC_0000422401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000422401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000422401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF10">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAB co-repressor" evidence="2">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000422401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23577" checksum="78A2B62EF7CE35FA" modified="2016-09-07" version="1">MQLPFNSPQRLQEYRRYSAIYGRFDAKRKPDKPLTLHEVSVNEAAAQLCLRQPALLTRRDELFPLARQVVKDAGYNYVKGMKKGETDIKRQRSLVILDSFYRSELSQSPQSSASAGSPGLEENTIDSGNELAAASSSSSLVAMIGNRDDAGSIITSNRKKRRRESSQEQEQLEISSSVVSLVTPEKQQRLVVKRHGTVEKQCNTTSAASDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA12</accession>
    <name>A0A183HA12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-cell immunomodulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4324</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003233">
        <property type="protein sequence ID" value="VDO39630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA12"/>
    <dbReference type="STRING" id="387005.A0A183HA12"/>
    <dbReference type="WBParaSite" id="OFLC_0000432301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000432301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000432301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="7">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO39630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000432301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33242" checksum="ACB95A3C57C91A19" modified="2016-09-07" version="1">MWNHYIGAWQDFHITGLEGSDLVSKKDEGNVVFRVGDFSLDGYPDLIALVREKTQNPMILENVPCTDCISNASRRFELRTSPRLIQPADVSLGQIQLASFFDLKEDGTLDVLLEYKDADQSMAVDFIKCEDKGDTTFLKVQVFSSSCDHMSDSWGHDQVGSQCQMPQTTHRALHTPFALFGLGRSPNFVDYVHIGSPRVPLAGSLYYGNQHYYLKQIVPNSRLIVVPPKGDGIHWQSRLYLTPSQLIKQSLMVLISICIILLLVVVFLHYRERRADKHERQAQSHRFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA19</accession>
    <name>A0A183HA19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS4330</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003240">
        <property type="protein sequence ID" value="VDO39655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA19"/>
    <dbReference type="STRING" id="387005.A0A183HA19"/>
    <dbReference type="WBParaSite" id="OFLC_0000433001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000433001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000433001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="201"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO39655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000433001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41576" checksum="52D7964F58681CC0" modified="2016-09-07" version="1">APADGEEVDHVCVCATEDEDCTPLELPLASDGTLPCSTLSHSFPKAVGLKYKNPATGLFRSLPVDEEKKCVMAPKGGWHGHRYVAIIDDSLSSSDRLEGQCGQTDRLNMPVDLFVRNLSFKTTEEQLKKFFEQYGEVQYAEVKKDYRTGLPRGYGFIKMKTLEDQEKVLKEGDFYIDGRMAQVKYPDHGQDGGDQDDRITTKIYVGRVYAEITEGDLHKLFDEEAKKISSLAKVERVFLPKPCRGFAYVSLNDPKVVKRLCQIRDFVCAGKSIYVSIPRPKKQESEPVRYSGMRDYRSHPYRSSYGRWDDEPINRKGYYNDDPYAGRTRSLFDDFPSSGGYGSRSGDMYGGGGYSGNSGYGSGGSSRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA73</accession>
    <name>A0A183HA73_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DRB sensitivity-inducing factor large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS4385</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003302">
        <property type="protein sequence ID" value="VDO39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA73"/>
    <dbReference type="STRING" id="387005.A0A183HA73"/>
    <dbReference type="WBParaSite" id="OFLC_0000438401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000438401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000438401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000013">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000016">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000438401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48668" checksum="CD83DD775B365CB7" modified="2016-09-07" version="1">QKNRYCNFREIGGEVSTDGDFVTFEGNQYRRGFLYKWFPLNIIQVDGVKPSLSELEKFQETSDDLKKELEGMKVKDLSYIFSPGDYVEVADGELVNLRGRVQSVDGEKIVMLPDHEDLKEPLTLNACELRKFFKTGDHVKVINGRYEGDTGLIVRVEDNLVILLSDLTMHELKVLPRDVQLCADVTTGVDSLGQFQYQDLVMLDQQTAGVIVRLEREYLEVLNMHGKVVRVKPQAIHGKKDTRFAQALDSQQNSIQVKDTVKVIDGPYASRGDAEDEKQGEIKHIYRSYAFVMSRKHMENGGLFVCKPRHLLLIGSKANTKIGDFVVKGLTIPDPFSSPRHVELGGQTPRPGNMSSGRSVRGGATPSQHGKNEEVLDGSSVGVPSTGGFDSQNRIRRDNQIIGKSVRITQGPLKGYFGIVKDATEQTARVELHSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCF3</accession>
    <name>A0A183HCF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sfi1 spindle body domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5166</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004297">
        <property type="protein sequence ID" value="VDO42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCF3"/>
    <dbReference type="STRING" id="387005.A0A183HCF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000516401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000516401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000516401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000516401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="36305" checksum="4C3686E092AC3C44" modified="2016-09-07" version="1">MKDIGKSFLDDLVTEVVAETVRKIGENKIEEGVNYVKKRLKDISERLDKLWLKQFVDHWRKRIAYRKEQEQKKLELLGSFPSLLPVKSGLICRRRDDYSLDKAFIDFSSLFFEQKINVFIEKRHARIARKVLTKWHLWTQLQIEKREFFTTTYTTSPLKRRQRLYNNNNDDISKKNDDKIRLTVALAEVECERLKPFQTTYQIYNENEQQLSWYKSLVERSSLLLDYFDEKTLEKGVEIAERNMQRIDCTQRWIKNENHPGYSGSFDKFTFDQRNYKKTNEFSVENEEYHPPTKKEVKFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCF4</accession>
    <name>A0A183HCF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5165</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004296">
        <property type="protein sequence ID" value="VDO42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCF4"/>
    <dbReference type="STRING" id="387005.A0A183HCF4"/>
    <dbReference type="WBParaSite" id="OFLC_0000516501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000516501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000516501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO42252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000516501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42142" checksum="B8DB022C9C2FBD19" modified="2016-09-07" version="1">MSNLHQQDQAFGISASNSDRNIFYPTLSGITTTTATTTPSRPAALVDQKLCESCNLKRNKELLERKMATLRLEIQKQLVNELVFREAQKHSTPLTENQLRMPKTISQRNPDLFKTTLCHFWSNGIPCRYGEHCWFAHGVHELRIASFVYPGLHRHDYEVRMNSANRLASLHGRNLERNCSLANVQSNVQSAPATIVGRNVPTDIFHRLSPIHENVNSMNWSTTQRGVSGGDSGIENTSTNNSPEILQYRKNLNDATHQFIPFQEPPLPVAPPHMKHPTDTSINGGQTNSSDEPYNYWLSTGTAQSNDMKVASSLEEMSWWSSDIFGDAYPSINRPSQNIQHNRNATQPNHNATQSMNEHCYSTCTKPKIDKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCH2</accession>
    <name>A0A183HCH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phasin_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004316">
        <property type="protein sequence ID" value="VDO42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCH2"/>
    <dbReference type="STRING" id="387005.A0A183HCH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000518301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000518301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000518301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000518301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17158" checksum="57539D2A7B323F11" modified="2016-09-07" version="1">MVETALNTDEFMSKKDIEIRLEHARRLHGIYMRCASEFAGFMNNMFNEITVLIEKTGVELAGHAIYGDIVDKRESIAQSAQEQTQSWFEYQRTGRVSVLCSALARRNAAIARRHLMTYSPRSESEIIVNVIPPILSATHATSILPISRNGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCT1</accession>
    <name>A0A183HCT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5293</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004478">
        <property type="protein sequence ID" value="VDO42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000529201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000529201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000529201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000529201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="6136" checksum="EE320E66A6291766" modified="2016-09-07" version="1">MDDLFLYVRSTSHLNIEFCSTTRKLQKIRQMISSEEKMKMKSAHTNWLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCZ7</accession>
    <name>A0A183HCZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPPIV_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004564">
        <property type="protein sequence ID" value="VDO42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCZ7"/>
    <dbReference type="STRING" id="387005.A0A183HCZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000535801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000535801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000535801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000535801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25906" checksum="DA24B76889551EE0" modified="2016-09-07" version="1">MRKYLKQFKIVFLLKIVDSILKELAAIRHKYEYYFMPNKSQVLFYLSDASLLRIQRAGSELQITDSIDFPLFDIWEDVNCEKSTLILESYGRTVLLISNNSSTGCLSRNKSEPPLLVVNDWNGDLYAYFVPGDPFLIEDSEKQTMARILAAETAYGRVTVWVCVLEESGQEVARMKEYSTIHFTKNVGNFQLKLLALAAFAHLTVSEFFKNKSCCGCFFSMLFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDM8</accession>
    <name>A0A183HDM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5589</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004878">
        <property type="protein sequence ID" value="VDO43658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDM8"/>
    <dbReference type="STRING" id="387005.A0A183HDM8"/>
    <dbReference type="WBParaSite" id="OFLC_0000558901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000558901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000558901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF2">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="443"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000558901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="559" mass="61930" checksum="64F3F27473C21A0C" modified="2016-09-07" version="1">MGQNGRPQLCISDNQCANNYWCHIGADSQTTVCCPGGAEGYAVCLQPMAAGTGNKNLLRWYYDESIRQCLPFTYHGMMGNQNNFLSKQECQLTCQGTFTNLFIKNEMLSRILSSYFADNHAILPPFIMRYCPHYVIFPPISLCYIIPIYTCKFTNLIISSIFTFDFFSTAKSNLLLAYVNVCPQGDPLLETGTKQPRLCTFGENSCGPKYWCHLGLVPNEYQCCPGAETEPAACKMLFAVGIKGAPALPATRWYYDATTLTCKTFEYTGRKGNQNNFLTEADCAATCKVFRNPCNQPVVLPAQTCSSSRPCAIGTYCHYGAKSETTICCPFEGNRCEKPVDRGTGNVSLQRWYYNSQKGICEIFTYNGLHGNANNFLSKENCEIACRINPCSEGQPFTTSNGVYQTCVVSSLHINSCPSGYWCNPGSNSLTTVCCPGAVNDPCNLPMVVGEGNEELERYYYDPVTRACRVFIYHGMKGNQNNFLSEAACQLQCHPLENPCVGQPATTTADQILFCSEINKEVCPVNFWCHIGATPKTTVCCPGGNILTFRILTKTDRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEZ9</accession>
    <name>A0A183HEZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6060</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005548">
        <property type="protein sequence ID" value="VDO45261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEZ9"/>
    <dbReference type="STRING" id="387005.A0A183HEZ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000606001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000606001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000606001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="9">
        <location>
            <begin position="154"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO45261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000606001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34081" checksum="EAFF17D9ABCFFEBB" modified="2016-09-07" version="1">MLEQVRGSKELEIVLNHTTNAWEDVTEKKSTNFCQQLARLKLAIKLRQKFFVAHPNCQQLLSAIFYKGLPGFRDRNFVIKILIILGVAIASPLLSIIYFITPKSSFGKFARRPFIKFLNHSASYCFFLFLLILANQRINFDLIFGEKSASMVHDEYNQDLNLKEVRGPPPTPVELAILAWVFGFVWVEIKQLWKEGLCDYCSDLWNILDFITNALYLCTVVLRIVAYLQVEAEMRNPEMRHLGRHIIRRNWDEWEPTLISECVFATANIFSSLKIIHIFTVNPHLGPLRISLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF38</accession>
    <name>A0A183HF38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Golgi apparatus protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6100</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005608">
        <property type="protein sequence ID" value="VDO45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF38"/>
    <dbReference type="STRING" id="387005.A0A183HF38"/>
    <dbReference type="WBParaSite" id="OFLC_0000609901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000609901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000609901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="197"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000609901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37038" checksum="11952D8632A4D29E" modified="2016-09-07" version="1">MEPECSKLLAERANMMGQNYRLSHPLLSGCATELKEFSCAPSALFSGSPNFHLSWVLLCLENAAYANPGKMSEKCQHEVISHRKMMMSEFRLSPEVVLTCGREIDLFCSPKGDIEAEGRTLHCLLSHAQERNENQKLGPQCMQALQTVMKVADVGSNYKVDEVLYASCKTLIDGPCAMDAQSEANTLSCLMKHMDFDMPKDCEQRLLEVQYFISRDWTLDPELYSACHEDAVSKCSASANWHQQLNQQQGPDPGPMVLACLYRAAYNDQNPLKPECAASVRHALRTRAARVNLMPDIESSCREALSEYCSNDVKPMQVCILKIFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFE0</accession>
    <name>A0A183HFE0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6202</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005764">
        <property type="protein sequence ID" value="VDO45767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFE0"/>
    <dbReference type="STRING" id="387005.A0A183HFE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000620101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000620101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000620101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO45767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000620101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35829" checksum="9C422953FD6F7DEB" modified="2016-09-07" version="1">MLFKMFSSINDIKNRQILLKFVVPVCDVYFHGLDVRSNNAQLDKNDVIDNAELMIIGSFLEVIDNLSENEFRTVTKSIYTRLQDALSPEAKMEIRYRSITIFRFLNRFYDSYKNISLPHFGRFFGLLPDIFSRCNSHITDSKSLIFYDGEDSAATANVSVGHLLMVMIDFVTNCARHPVFFTSERAKVVLDFLVNELENKDIPGHELRCVPHLAECFYNIINCQNEILTDTINKILLKTRSRSSKIRYRTLLVLEWLFEHMGDAVAPTLPSVLPFLSELLEDDNRKVEMQCDAVIGVLRKNFGEEITEGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGG1</accession>
    <name>A0A183HGG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6574</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006330">
        <property type="protein sequence ID" value="VDO46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000657201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000657201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000657201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000657201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="19188" checksum="D94C9852BAEE4305" modified="2016-09-07" version="1">MTKINVISKWHFMKFMMQNPPIYSYSNEDEEWDKYGSYKPVLHITICQLCVILQRLQNDVNEFIYMHVIPTNSRLNQLITVTLLPNDDIQQYVTLHLHPFISDENDNYDELFRRFQLFLSFINIFIINSKLFFNISSKNSILRNSHFLSNYYRNFINCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGI7</accession>
    <name>A0A183HGI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MTS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6599</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006368">
        <property type="protein sequence ID" value="VDO47056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGI7"/>
    <dbReference type="STRING" id="387005.A0A183HGI7"/>
    <dbReference type="WBParaSite" id="OFLC_0000659801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000659801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000659801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000659801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15998" checksum="7E0F41083B57AE92" modified="2016-09-07" version="1">MHPTPLYRITDEQKDSVYEPAEDTFLLLDALEKDREALEKLEPNVVVEIGSGSGIVSVFCQQLLRIPVLNLATDMNFRALQCTETTAQLNNVSVEVIQCDLLSALKLSSLIDVLLFNPPYVPTEQEAASDSVSGFFFFFPLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGN8</accession>
    <name>A0A183HGN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6651</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006450">
        <property type="protein sequence ID" value="VDO47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGN8"/>
    <dbReference type="WBParaSite" id="OFLC_0000664901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000664901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000664901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000664901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15339" checksum="00E3A2C9D1F1BDB9" modified="2016-09-07" version="1">MVPTLTNFGDVNNRDQGNRIFAHFGQGDDVRNGNLFSMNKNVLSSNRRGHNRSLSHEQSRYRAVEHNGEINHSDIFDENADLQARNAFDQVFKRNDRYWGRRGKRNSTNKNRPPGKHNPLNTIGLDESSNIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHD3</accession>
    <name>A0A183HHD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DRIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6894</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006847">
        <property type="protein sequence ID" value="VDO48320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000689401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000689401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000689401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056581">
        <property type="entry name" value="TPR_Edg1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24293">
        <property type="entry name" value="TPR_Edg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Edg1 TPR repeats region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000689401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30646" checksum="894BCDAF1BB09681" modified="2016-09-07" version="1">MILSVNKFAATKFYVVFFLFFRILYVSEDGLVIETDTFDSLLSCFDKSLWTCRYAMASWFYKCLRSYKKEIPSLLYEALKEEKRETVKAVKIDSDDNDISGRSLMRKLFELATIHPELALDIIEDGFSTSVSITGCDISGALVDVIRDHNNFPSSKISGLVEVIKVFANQIDLSRQTIPLLTEISESSFYGLRLIEPLLLIQEAVICAIYYDTKSTEDLTAVPFSVLEIENQVAVKLLKLFCELAKDHIQKEIIDLRRSYLKNKVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHK8</accession>
    <name>A0A183HHK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006973">
        <property type="protein sequence ID" value="VDO48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000696901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000696901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000696901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000696901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9730" checksum="2FFD20A2A6020AA8" modified="2016-09-07" version="1">MVDRIHAAFVFVFVVSTSSAIKCHIYFRRGKSPPKINETDDCESNNRHLYQMKGCDADDIQDNMLIYIPSLSGKSWENIMEACLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIE5</accession>
    <name>A0A183HIE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7258</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007448">
        <property type="protein sequence ID" value="VDO50079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIE5"/>
    <dbReference type="WBParaSite" id="OFLC_0000725601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000725601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000725601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000725601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19445" checksum="368C0D3490E5B71A" modified="2016-09-07" version="1">MRTIFLFTNNHQIISLSLQILSVCQSSLNEVKRYAIVMNTCASCKLMLFLLHCSMQKDETERYNYWKNRSLSLDSFIASKSNRKFAFIALLNSWQKLLEPHIKITDFPTAKKYSRSLLAENTKSLIGAVPTAGEDVVATDRTVGSTVPLSIRNLKAKSAIGNGIRININSTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIN0</accession>
    <name>A0A183HIN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007610">
        <property type="protein sequence ID" value="VDO50532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIN0"/>
    <dbReference type="WBParaSite" id="OFLC_0000734101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000734101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000734101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF193">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000734101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26392" checksum="73DE1EAC01AB6CF0" modified="2016-09-07" version="1">MMAVVRAFENKEYTLGRDGAIFFFLEYINYLDEVNAELENTERLIAMQSTVGANQHKNAAQKFDSHLKSKYFMKHFYLLINTSLLFQQLSAVLLYHQFVWLLSLSFYFAIDLSSHVTYAFVMATGSSKERVIHALESLGWPFFSFKFQSAVSTMAGISILYTYNAYIILTFFKTIWLTMVIGYYMSYCLSQFLLVFFLYYSTVIVALSSCLSYKILELRFATEVSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIU4</accession>
    <name>A0A183HIU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7409</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007722">
        <property type="protein sequence ID" value="VDO50860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIU4"/>
    <dbReference type="STRING" id="387005.A0A183HIU4"/>
    <dbReference type="WBParaSite" id="OFLC_0000740501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000740501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000740501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000740501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41375" checksum="3BA5513DF6C98DCA" modified="2016-09-07" version="1">MLEKGDWTTVEKKEGPVSSSIQSQTDLVVRGTDEKVVIQKKAEKIMEEDVEQEGSISFSIQPQQTDFDQSTSTNWKLNASFSPSMLMKTDQVTHRSVTDITNATGITRIELIKMISELPAVRQNKTGKDRPYETEEIISTSEIVPMKVLFEKKRLDVAKKTNPNDIYIGTHLLTLAPTMVNLPTWDDELQTSNYINLPFERNTSMVEERMEETVGEIDRTQEELVNILKKGTMTNDSEINFVETSSNTPSDDVKFQMIKIETAKSKSTKINVLADVSESDRKHDVYKILRETLEANTTATKLPDKKKTTIQVYWNGSLENETISNDTISMMKYEFGGMIFKNDYTTLRNKKVVENDRQKLVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ22</accession>
    <name>A0A183HJ22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Suf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7484</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007850">
        <property type="protein sequence ID" value="VDO51193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ22"/>
    <dbReference type="STRING" id="387005.A0A183HJ22"/>
    <dbReference type="WBParaSite" id="OFLC_0000748301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000748301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000748301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000091">
        <property type="entry name" value="Pre-mRNA-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO51193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000748301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31852" checksum="642D785319438695" modified="2016-09-07" version="1">LKSLHVDRSSSDRETTDLLKLCWKPLKDDSRNFDAWTHLLQYIEQLVSLDHLNDIVTCCSWDETKAAREAYDDFFKRYPYCYGYWRKYAEFERRHKHYERCIEVYERGVTAIPLSVDLWLHYIAFVKEIAQHQENTVQKTRLVYDHAIEACGMEFRSDKLWDEYINWELSNGETVRAGALFDQILSIPTLLYSNHFDKYKAFVNSNEPDRVVSQDEYNEIFTKVETDLRNVVDGDLFLLEDYVDESPPEYIPENGEEPPKKIFTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJD5</accession>
    <name>A0A183HJD5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS7599</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01008044">
        <property type="protein sequence ID" value="VDO51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJD5"/>
    <dbReference type="STRING" id="387005.A0A183HJD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000759601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000759601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000759601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000009">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000759601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37467" checksum="9C584123B109C382" modified="2016-09-07" version="1">MRFLYESILFFLTKTILPPAPVFLSNFSRASLHSSMSAAKYTIEEFGSLYGLDYRIYFKNQNGSHISPWHDIPLFVNESEKIYNMVIEIPRWTNAKMEMSTKESMNPIKQDVKNGEPRFVDNFFPFKGYIWNYGALPQTWEDPKHVDPVTGACGDNDPIDVIEIGSKIHQRGDVIAVKIVGVIALIDEGETDWKLVAIDVTDEKADDINEIKDVEKHFPGLLKATREWFRNYKIPTGKPANQFAFNGLYKDADFAHGIISETHEFWKRLIKEPSPELNTEMIHNIDGAAHVVDSFAWEKIIAQQSSLKAKKDVPKKKLDKWHYIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJN0</accession>
    <name>A0A183HJN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7696</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008207">
        <property type="protein sequence ID" value="VDO52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJN0"/>
    <dbReference type="STRING" id="387005.A0A183HJN0"/>
    <dbReference type="WBParaSite" id="OFLC_0000769101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000769101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000769101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040384">
        <property type="entry name" value="ORCKA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864:SF1">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000769101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26888" checksum="283A8DE87AAD8C89" modified="2016-09-07" version="1">MEKMPDSNKGSRLHEKYHKDDGFWRGRRSLYSIEGDRMVLPLVNSDIAGLRRGKGAGAFENMEDDGTGIEIRYLDDYEGNEIGLKKRALDSLEGAGFGMEKRALDSIEGEGFGLKKRALDALEGAGFGIKKRALDELEGAGFGLKKRALDSLEGEGFGMKKRALDALEGAGFGIKKRALDELEGAGFGLKKRSPDPSANTRYGARIKMDKIQNEAYDRLQNYLFQPTGKFFNLKYKIKLIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK96</accession>
    <name>A0A183HK96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7908</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008564">
        <property type="protein sequence ID" value="VDO53103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK96"/>
    <dbReference type="STRING" id="387005.A0A183HK96"/>
    <dbReference type="WBParaSite" id="OFLC_0000790701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000790701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000790701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000790701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19923" checksum="8AEA1BDBC3C8EA16" modified="2016-09-07" version="1">MGLEVLTRLADADGSQALSDHCHDAGTFACCLSALSRTPLIMRPGAGDTPVPTPCRRHAWPGRSVATAKHQPGLLLSLHPPPHASQSLGSQALATTPGEPTKFLGPVITMPMSGFLCSTSLGWPSVFYVHATITLIFLILWWILYRDQPDDVPWVSAYELSLINDGKTDNKAKRSNEKVCHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKH5</accession>
    <name>A0A183HKH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7989</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008709">
        <property type="protein sequence ID" value="VDO53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKH5"/>
    <dbReference type="STRING" id="387005.A0A183HKH5"/>
    <dbReference type="WBParaSite" id="OFLC_0000798601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000798601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000798601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000798601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29204" checksum="D5C7B1E035531688" modified="2016-09-07" version="1">MDDDTSTASCSSEVSTLKFISIRCIALILFQTNVHWRKLDEAIQIIQRWLYKANLPALIKKQLQTGLRDVYRETERWNEKHAKLFDEEGKNEKNPMPRQRVHRSDHLRLFYGSIVWKYNKYEIDDLKTALAIIAKDCADWPQMQFQLACAYAIHHLLNERNFDRIRLKAFAKKLSGHCLYDFWFALLDNTNDAWGKMFSSDNLAPKQILSLAFQFAIVNGYFELVIFIWDNITDPQREFIGISFPKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL73</accession>
    <name>A0A183HL73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3_UbLigase_R4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8234</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBR4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009150">
        <property type="protein sequence ID" value="VDO54698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL73"/>
    <dbReference type="STRING" id="387005.A0A183HL73"/>
    <dbReference type="WBParaSite" id="OFLC_0000823401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000823401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000823401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025704">
        <property type="entry name" value="E3_Ub_ligase_UBR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13764">
        <property type="entry name" value="E3_UbLigase_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52043">
        <property type="entry name" value="UBR4_E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin ligase UBR4 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="UBR4 E3 catalytic module" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000823401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26546" checksum="12047E410D95931B" modified="2016-09-07" version="1">MAGSRSEWASAALHNANTKCNVIVPIWSKRVKDSDMEHSFQRLSTDLEVAVDCDTVNLDSLTLDIAELLDRFVKFRSFSALSHGGGRESNMQYMAVLILLAQYLKKVSPSSEPGEAHSFIHQISISLVMDTTEQWNDKRLDLLKILQESKRSWKDARHELLVWATVNYYQNKILQYKIDDRTELMRENIIKIMENCSKFVTYFDSEISQCASYDELMKTIGKINLIFHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLE4</accession>
    <name>A0A183HLE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8305</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009277">
        <property type="protein sequence ID" value="VDO55039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLE4"/>
    <dbReference type="STRING" id="387005.A0A183HLE4"/>
    <dbReference type="WBParaSite" id="OFLC_0000830501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000830501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000830501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000830501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25895" checksum="096D8945F1192336" modified="2016-09-07" version="1">MRITLLDINVCSGVIITFRHIITAASCLDFNENGLKKTSVSEFKIYGGSTCLYINLTNENHDNILRFACPTEDENTLKVASIKPIALLVPMSSVINNVASIRGVPFYEAFSDIAIFEVEPIDKLAETLNEKNKDLVEAQVNFDVACISEPTIRNEGAGYIIASYGRRSKFSSAHFTTRRITRNLFNDHGKNPINVKLNVILENNVYIDECPASIPMQACARIMIIEGEQTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLF7</accession>
    <name>A0A183HLF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8323</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009300">
        <property type="protein sequence ID" value="VDO55101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLF7"/>
    <dbReference type="STRING" id="387005.A0A183HLF7"/>
    <dbReference type="WBParaSite" id="OFLC_0000831801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000831801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000831801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="38"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO55101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000831801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30333" checksum="7AF25AAC52AD6CE0" modified="2016-09-07" version="1">MPSVTENGVVASSSDGASVDYEEAYLFPERTKNANSLSPEQAFAHMVKAMLGTGLLSLPLAFKHAGLWLGLVLMVILCGICLYCMRLVVYAAHYICQRNGRDVIDYANVMRSAIESGPTWISIHGYFFKQLLNISMFCTQLGFCCVYFVFMADNIQSFFDVNTVIHLPKSVWMVLLLIPILSICSIRHLNKLAPFAFIANCLYLSAVCILLYFFFTHLKPSSDFPAIGEIKNIPLYFGTVLFAFEGVAVVWYKNLVYDVFILLALNKFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLH9</accession>
    <name>A0A183HLH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8341</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009330">
        <property type="protein sequence ID" value="VDO55157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLH9"/>
    <dbReference type="WBParaSite" id="OFLC_0000834001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000834001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000834001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000834001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="4113" checksum="A54B9E493A4E55DE" modified="2016-09-07" version="1">MEHCSLLEIGQWHSFFKGIKSRHLRYFSVVLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLY5</accession>
    <name>A0A183HLY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8497</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009657">
        <property type="protein sequence ID" value="VDO55962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLY5"/>
    <dbReference type="STRING" id="387005.A0A183HLY5"/>
    <dbReference type="WBParaSite" id="OFLC_0000849601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000849601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000849601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000849601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15904" checksum="2DDF821285D49A34" modified="2016-09-07" version="1">MGITSIRLHLDQQAVMIRQDVYGSVRGQRKNDYLTSINAGDEEEDAEDELVGPMAAAKAAYSAPKRFVEEAARHGKGDDPFAETRTKTIAERQSNYQARARHRQISPERADMFADQTPDIRDRSYAQIMKEQMLREETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMV4</accession>
    <name>A0A183HMV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Str_synth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010280">
        <property type="protein sequence ID" value="VDO57538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMV4"/>
    <dbReference type="STRING" id="387005.A0A183HMV4"/>
    <dbReference type="WBParaSite" id="OFLC_0000881501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000881501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000881501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000881501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27042" checksum="AA5BE7A9A71225C0" modified="2016-09-07" version="1">YIYILLISLSSQVIPCPKEPKIELSRTRWITVSPRGELFVVSGDNHRSAIWMYNQSRKGWKILKESRKTRYQYLRIAEDQAEYKAVVLLTCDAAQNRILLFVVDHTGTLINEYDLTKTYKLDECIKNPASAIVDSLGNLLILDYATSRLWALLSNTKGMRHIKEIVIPAPLGPQEALGITAHGDWIYMTCFARREVICLRYLVNGALVSSCCSISSETPKSDRRAISLPRPTRKPNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP46</accession>
    <name>A0A183HP46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein aurora borealis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9256</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011167">
        <property type="protein sequence ID" value="VDO59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP46"/>
    <dbReference type="STRING" id="387005.A0A183HP46"/>
    <dbReference type="WBParaSite" id="OFLC_0000925701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000925701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000925701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000925701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31372" checksum="7C677BA27F8B24B0" modified="2016-09-07" version="1">CNVEPFVPPSERDDAPLAGILQNPELDKIDPRRFFPDYSRNKILRFSRLFGANINSSSRTRIWWPSKTFRPIVSPRQEEDDETIAAMAIKVEDPRIFEKPTKFVNTSYSIETYGPKLLFADPPAPEDCIVDDEVLLMRPSTSSVSAKNDNGDSDVNDASPWRFGPARIWYDAMNVLSNPSHFDYGFKLKREQPLRKKIPMKDEKNDKSEDEVVEEEIGLGLAASEPFPPETFLPVNLIRWEDDIILDEEQARRQVFFHQIRSKVTKFFTIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP81</accession>
    <name>A0A183HP81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erbb2 interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9294</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011251">
        <property type="protein sequence ID" value="VDO59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP81"/>
    <dbReference type="STRING" id="387005.A0A183HP81"/>
    <dbReference type="WBParaSite" id="OFLC_0000929201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000929201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000929201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000929201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22905" checksum="19F2E2EA2DF30C01" modified="2016-09-07" version="1">FRTYSNNSSKSSFPIHAYNKGNLYINDTSTTSSLEYREGCDLRTSYGILSSNSDFPKQGNSGKSEEIVRNSSPTALIMAYTNDEGVGLSSSQQMSNARRFERRYHTSDGIDITKPKVPANLPPGILKRFSWNVSTAVGGSSRKITNRMNEQNIRRQSQSTVASSESFSSSTSGFSTASSYMEGSTVTEEVTPAANLDMHISTGKKIFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP99</accession>
    <name>A0A183HP99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9312</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011281">
        <property type="protein sequence ID" value="VDO59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP99"/>
    <dbReference type="WBParaSite" id="OFLC_0000931001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000931001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000931001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000931001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="23243" checksum="10500B19B5020B18" modified="2016-09-07" version="1">MVTTNGTDGKIELSDELKVAIAAEVRAQIVPVVKEIVHEVVTEIRSVMTEVMAPIYDELNRLRTSTTGTATTTTTNGSNTNNTLQMHAASAAAATSIATPATIVAYPSESTILAEVYAATNNVAVTMGGTACADAATAAAVAAQNAQLQQFLKENAGTAYNSNKGKMYMDDGVGTKNPDDFVEQPSEPRARESTSDCAAYNYVYYNTASAVPVMSMLEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ59</accession>
    <name>A0A183HQ59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9621</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012003">
        <property type="protein sequence ID" value="VDO61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ59"/>
    <dbReference type="STRING" id="387005.A0A183HQ59"/>
    <dbReference type="WBParaSite" id="OFLC_0000962001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000962001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000962001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000962001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21235" checksum="2710108B21FF2EC9" modified="2016-09-07" version="1">MSKQSINYKRNRKKPKRSSPGRTPRPFGRIHQKIDFNNIVKDISGLKLTNRLSKNLSKKKLLMPDSTFREPNKKKINESRKITEDSKFPDKLLQYNRKDQSETKMFPAPNSFERQQVENVKKRDGIMEVTKSERFPSTDTNSTIKLSVKQRAQMFEAAVANANESNIPMKNTRRFVNKMDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS75</accession>
    <name>A0A183HS75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6PF2K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10329</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013661">
        <property type="protein sequence ID" value="VDO67642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS75"/>
    <dbReference type="STRING" id="387005.A0A183HS75"/>
    <dbReference type="WBParaSite" id="OFLC_0001033601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001033601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001033601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043540">
        <property type="term" value="C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF15">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO67642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001033601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8279" checksum="1128246E99B4375D" modified="2016-09-07" version="1">MVKIFDATNTTRERRCWLANFCHREDRDPPFRLFFIESICDDPDIINANITVSLNLNYHSINYINSLVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSF6</accession>
    <name>A0A183HSF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eph LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10420</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013860">
        <property type="protein sequence ID" value="VDO68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSF6"/>
    <dbReference type="STRING" id="387005.A0A183HSF6"/>
    <dbReference type="WBParaSite" id="OFLC_0001041701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001041701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001041701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eph LBD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001041701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7417" checksum="BDBEF20B2697A75A" modified="2016-09-07" version="1">MQQRWLEETYRGSEGIDNRRAYVVCNVDQPNVDNWLRTPMINVKGANRLHIEVVGLIFNFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSI5</accession>
    <name>A0A183HSI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YebC/PmpR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10452</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013943">
        <property type="protein sequence ID" value="VDO68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSI5"/>
    <dbReference type="STRING" id="387005.A0A183HSI5"/>
    <dbReference type="WBParaSite" id="OFLC_0001044601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001044601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001044601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001044601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11914" checksum="A578185B795B0D18" modified="2016-09-07" version="1">MEVMRREMLLHARRLWVSSHFMKGHSKWDNIKDTKLAASANKAKAAEQLMAKMKRIVRAGGPDLKFNKDLVQLQLEYRNANFSDDAFQRALKNVQVRIFHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSR5</accession>
    <name>A0A183HSR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10524</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014116">
        <property type="protein sequence ID" value="VDO69146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSR5"/>
    <dbReference type="WBParaSite" id="OFLC_0001052601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001052601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001052601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001052601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23223" checksum="9453FCC998BFDBA2" modified="2016-09-07" version="1">MDTIKMSTASSGCIERDPVNILQETGHQYLPSAALRPNNTLTTNTQPRIIRNSVLRRTSPVTVQGSRAITTVARVMPNLQRARSHLAGSIASMKSVSSETSGNNCNDDKRQLDASGRIQIFGKSVESRLPVGEVLRRIRIADQKPSPADGHHGRTTNSSGTSKDEVFFDNSRITERKLSNQEKKSSVRNEMEAALQYRIPQNVHDIDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSV0</accession>
    <name>A0A183HSV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10562</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014212">
        <property type="protein sequence ID" value="VDO69513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSV0"/>
    <dbReference type="WBParaSite" id="OFLC_0001056201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001056201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001056201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001056201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14259" checksum="F3188746F2DDB7EF" modified="2016-09-07" version="1">MHFDPLRKHLQNLDCYSVNFVVCHINRKRKFLQDVNLQASLEELKKLELPEMDTYSLGHLVRSLQLRMGNYHLSKVHRVSLLIYGVRGFHNRAEMLRYLDHSLKSEDTTIDMMSEQQLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU68</accession>
    <name>A0A183HU68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015392">
        <property type="protein sequence ID" value="VDO73233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU68"/>
    <dbReference type="STRING" id="387005.A0A183HU68"/>
    <dbReference type="WBParaSite" id="OFLC_0001103001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001103001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001103001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001103001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4280" checksum="E04DC6FE257CB6E1" modified="2016-09-07" version="1">MTIAKECKNDECEKRWPGAICRGGRCACPQDSIRLINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUA8</accession>
    <name>A0A183HUA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11071</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015514">
        <property type="protein sequence ID" value="VDO73562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUA8"/>
    <dbReference type="STRING" id="387005.A0A183HUA8"/>
    <dbReference type="WBParaSite" id="OFLC_0001107001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001107001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001107001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552638" evidence="1">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO73562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001107001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24861" checksum="4FF663B05869EA8E" modified="2016-09-07" version="1">MLLITSIFISIQILVYGDSNLVANEKGKEEDALLLPGNPYAATKAACESYIHFCCESFAMPIIILRINNIYGPNQWDVKVVPRFIKLAKNMENFTVQGSGTQLRSWLYVDDAAEGIRKAVEIGIIYEIYNIGTYFEMNVIDLAHIIQAEVDRQLGRSPTSMKFVGVLDRPYNDLRYLLDYSKINLNIGWSPKVTFEEGNFLRCVIYQNIIRSLFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVI7</accession>
    <name>A0A183HVI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase_RecD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11495</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016650">
        <property type="protein sequence ID" value="VDO76869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVI7"/>
    <dbReference type="STRING" id="387005.A0A183HVI7"/>
    <dbReference type="WBParaSite" id="OFLC_0001149901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001149901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001149901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO76869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001149901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7349" checksum="D50935982E4A581C" modified="2016-09-07" version="1">MHLTSLDVITEKTLQATCCITAARGRGKSAALGLAIAGAIGFDYANFVMRNYANFVELCPLLTLNEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVZ3</accession>
    <name>A0A183HVZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein GOLM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11654</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017117">
        <property type="protein sequence ID" value="VDO78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVZ3"/>
    <dbReference type="STRING" id="387005.A0A183HVZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001165501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001165501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001165501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001165501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25540" checksum="B697B812666F2637" modified="2016-09-07" version="1">FFLILCISIFHILQRRDELNEQLDELESKGSSMTEADHQKYRELVNELAKIRVPFPIESNSNKNITEQEQSKSLSPEIVISIKDDDSCLEQSKNFPKSEKYEKMSMKLEANEAEKLTEQQMQDTIGIKAEGFLEEKKDSALTNENSDEMIMKKKGVQWDDEVAENLRTDSDNGNKLIYEDDEQPEPRAQVLGTNEVYRDPRQVRLTELEAKQHAAKEAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW79</accession>
    <name>A0A183HW79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11739</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017371">
        <property type="protein sequence ID" value="VDO78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW79"/>
    <dbReference type="WBParaSite" id="OFLC_0001174101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001174101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001174101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF6">
        <property type="entry name" value="PROTEIN LET-653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001174101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13024" checksum="E1E1367754D0BBD5" modified="2016-09-07" version="1">MIEKKKTNKSCSGDYAFTYLSDRYMDRREVREVIKTKTLEDCLSACLDAVYYACRSVSYNRTDGDCLLSQHNQLSKPLLIKINNNPNYRIDYYENSCTNSWFFSFLIGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWM7</accession>
    <name>A0A183HWM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017767">
        <property type="protein sequence ID" value="VDO80115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWM7"/>
    <dbReference type="STRING" id="387005.A0A183HWM7"/>
    <dbReference type="WBParaSite" id="OFLC_0001188901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001188901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001188901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001188901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11542" checksum="956C8F11FD7AA372" modified="2016-09-07" version="1">MTEGIPKRKNLLNGSKKITATDGYFKAPDDAFDNEKPYKKGQKMRMTVEDAEMENNFCWETMVGQVILVNLFWHLNTTYKGGNYLLFRRSQNWSQWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX45</accession>
    <name>A0A183HX45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12058</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018217">
        <property type="protein sequence ID" value="VDO81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX45"/>
    <dbReference type="WBParaSite" id="OFLC_0001205701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001205701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001205701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001205701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9810" checksum="2CEDB19F7119EF54" modified="2016-09-07" version="1">MKIQLQRFHRFYFLNDTIGILVDFSRNNGNVTQNVIQFSHVNHSVTCEHARIWNFNVDDMLYESDTTNIIGTTALMNDKNISKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX86</accession>
    <name>A0A183HX86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018341">
        <property type="protein sequence ID" value="VDO81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX86"/>
    <dbReference type="STRING" id="387005.A0A183HX86"/>
    <dbReference type="WBParaSite" id="OFLC_0001209801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001209801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001209801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001209801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8725" checksum="8BCA7DB1A91E05C2" modified="2016-09-07" version="1">MFETASENGFRCSLCRPQGNAGSDAFNVLVCDNVTMNKCALEVLHLRSGGTLFRYPSSADSVYDFPSYFFAPRSHSFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXL7</accession>
    <name>A0A183HXL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018730">
        <property type="protein sequence ID" value="VDO83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXL7"/>
    <dbReference type="WBParaSite" id="OFLC_0001223001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001223001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001223001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001223001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11666" checksum="B7BB5A0C185BB38E" modified="2016-09-07" version="1">MCSSSRCIALGATVTMFRCCSRMERLDRDSMIVPFSSTWLPTPWVRSVSSFCLKSSTGASPGDHTWYFAYLQFLFLRHINKRYRIVFCWMTTTAYGSFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP2</accession>
    <name>A0A183HXP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12249</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018782">
        <property type="protein sequence ID" value="VDO83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP2"/>
    <dbReference type="WBParaSite" id="OFLC_0001225501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001225501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001225501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001225501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7693" checksum="3639CEF652F0DAD2" modified="2016-09-07" version="1">MVDNLCYRYTSPSSYFLLSSSESMVGDGGGMVIECYCTRCRERRYRSKMLLHRVICKLLEIQQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP6</accession>
    <name>A0A183HXP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12255</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018794">
        <property type="protein sequence ID" value="VDO83260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP6"/>
    <dbReference type="WBParaSite" id="OFLC_0001225901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001225901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001225901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001225901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4367" checksum="A0DFF2172C38666B" modified="2016-09-07" version="1">MNSLSSETKTECLVYVSSTKKYGYECCCYGSKIPQCQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP8</accession>
    <name>A0A183HXP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12262</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018822">
        <property type="protein sequence ID" value="VDO83353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP8"/>
    <dbReference type="STRING" id="387005.A0A183HXP8"/>
    <dbReference type="WBParaSite" id="OFLC_0001226101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001226101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001226101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001226101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12619" checksum="D6B253F76D25A65E" modified="2016-09-07" version="1">MEANSSPKKAPRQNSGRFRSAIKEKAYKSHIVHARHRRYLVDPSVSSTNTETEQEQNMVSATQMLKTLKRYSISGSDKDMEDGDMDDVLLHSGKKQLNESGSSTEAVSFINVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXS0</accession>
    <name>A0A183HXS0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12276</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018865">
        <property type="protein sequence ID" value="VDO83461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXS0"/>
    <dbReference type="WBParaSite" id="OFLC_0001228301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001228301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001228301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552664" description="C2 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO83461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001228301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="9150" checksum="AA7078AAB6C78B3D" modified="2016-09-07" version="1">MLFSLIVVFFLIFRSILSEKFWTNVKLERLEWLNDCDLRDVCIHPTLQLRLFNIFNNETVSRTLKVDFDEYMVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXX9</accession>
    <name>A0A183HXX9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12339</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01019056">
        <property type="protein sequence ID" value="VDO84052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXX9"/>
    <dbReference type="STRING" id="387005.A0A183HXX9"/>
    <dbReference type="WBParaSite" id="OFLC_0001234201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001234201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001234201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001234201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8406" checksum="EE281FCA3C57BE45" modified="2016-09-07" version="1">MINIGTMKQAKEILQTESNVQEVKCPVTVCGDVHGQFHDLLELFKMGGKAPDTNYLFMGDYVDRGYHSVETVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ48</accession>
    <name>A0A183HZ48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12760</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039925">
        <property type="protein sequence ID" value="VDP12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ48"/>
    <dbReference type="STRING" id="387005.A0A183HZ48"/>
    <dbReference type="WBParaSite" id="OFLC_0001276101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001276101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001276101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001276101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18067" checksum="376847412012F280" modified="2016-09-07" version="1">MNENNESSSASSTCDGDHASGNSPAGILSNNAIAVPSDPRRPTGPTADSDSNGESSFSNTVDASSDTIGSVSNYRTAGGGGGNSINISCSSFAKGQLSRSPVHYFFILFSILLPYYVPFPPIFQNDIYRCPRYAVIYIPGYWKIFSKKYTRGDVYIERRYHHAINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZT1</accession>
    <name>A0A183HZT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12993</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040003">
        <property type="protein sequence ID" value="VDP12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZT1"/>
    <dbReference type="STRING" id="387005.A0A183HZT1"/>
    <dbReference type="WBParaSite" id="OFLC_0001299401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001299401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001299401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001299401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8192" checksum="C46FB0C311348336" modified="2016-09-07" version="1">MNMAMSLSSPVMIVTYMIKRGRCNYVAMYGNESENLGNGNRVEKDLVELNKQLNYNTNMKRHPLDFIGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I063</accession>
    <name>A0A183I063_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13125</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040054">
        <property type="protein sequence ID" value="VDP12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I063"/>
    <dbReference type="STRING" id="387005.A0A183I063"/>
    <dbReference type="WBParaSite" id="OFLC_0001312601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001312601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001312601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001312601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58839" checksum="38C6B7D68BFEBCD4" modified="2016-09-07" version="1">MFFRRSGCIEKTVREIKILRQLNHRNVVKLIDIVTDKQTAADFRKDKGAFYLVFEYLDHDLMGILESQFVEFSDDQISSLMKQLVSGLEYCHSIGFLHRDIKCSNILLNNKGELKLADFGLARFYDEDQDRPYTNRVITLWYRPPELLLGEERYTTAVDVWSVGCILGELYTKKPMFQGNTEMVQLDVISKLCGTPSPENWPDVIKLPLYCSFRPKRTFPRVLRDAFGFIPEKPLDLLDRMLELDPRRRITSKASLTHPWLKDVDPSKVPPPKLPDWQDCHELWSKKQRKNRSASNSLLMSQSSQSHTQFVQQHYPLLPSSSHQSDSGTNLRSVPTLLSTKRLNIAHLSIENNTSSLKNVDAAIRAIQADPSNLEAARALLANLSPTAAASVLQLVSKSGVLPPAVMSALSTSTTSASHEHPRIQNQLSEILGQLASMEAKGSVSVAITRDLSFAIEPGILPEREKEAMRNPPHSVQLNMGNTSEMPVQSTNGGGVDCNRILVPLKSENSEKEQTPSKHSELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I090</accession>
    <name>A0A183I090_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty-acid and retinol-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13152</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040066">
        <property type="protein sequence ID" value="VDP13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I090"/>
    <dbReference type="STRING" id="387005.A0A183I090"/>
    <dbReference type="WBParaSite" id="OFLC_0001315301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001315301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001315301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016918">
        <property type="term" value="F:retinal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019841">
        <property type="term" value="F:retinol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31418">
        <property type="entry name" value="FATTY-ACID AND RETINOL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31418:SF7">
        <property type="entry name" value="FATTY-ACID AND RETINOL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0845">Vitamin A</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552706" description="Fatty-acid and retinol-binding protein 1" evidence="11">
        <location>
            <begin position="23"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001315301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56320" checksum="46B210FD20DD3FF6" modified="2016-09-07" version="1">MIVKFFFGVIFCVSKMALEIHSFPTEANHAVETDKAYEDKFSCSTNMKSVQHELNVFYNNLTAEEKMQLKKFAKISAANFSLTDTEFLDGLKIEAAGLFSKLIGLRDIINTKLDTMQPESRLFIEKLLRRFLAAFSQDGLINILESLKGFGKEVIDMFDGLSKPIQNDILNAFPLVGSYITSDIARLMLRKLAELDLLSRKSTLTPTVDRNKDDSGKHFPISQVIDPEEPENLDPEAAQSTNYGMKKEVTTTVYPLITDEEDEVLVKKISVDVQLIRQGRQPQPKEPSIHLPDPRAVFLLLSLSSNFGEKKIHTFSEFIPSSLLTFFGDLNDTDRNALLELTRNISRSRLTTDTEKEFLEGLEVILFLQKKSENAYQKVMGVQNYLSHRIERLKPESNCFIKELSDRYVALFTNPQTAPRGTFMKLKLFANETFQKHDQLSAVVKNDLREAFPEIAELITNPRFRDYVRRVFENTDVKRAFNRADRMINPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0C9</accession>
    <name>A0A183I0C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13191</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040082">
        <property type="protein sequence ID" value="VDP13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0C9"/>
    <dbReference type="STRING" id="387005.A0A183I0C9"/>
    <dbReference type="WBParaSite" id="OFLC_0001319201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001319201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001319201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001319201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35321" checksum="8AD77EE0ABB82978" modified="2016-09-07" version="1">MAMLPSISSNHSEVLITAIEMVAEPKPLLAITFACISLLALLANCTLLIYIIYNRLYRNFISSHFIAHLCITNAATLCLLIPMLIYNVWTGVNIWAHSNVMCRVQALLTCATWTVIHFMALCIAGVHLLTFARIHYEQLFGLSPNMLCVLSWLLAFGLALPTITNGHIIIYDPSFRHCIWGDSDSGLKFLTYLLILGVFIPASLASYAYIRVLGILYHSPIVFQSIGLYKSRFLVYSFLFSPFYQLPFYAISIVKDWRKPDSTVPVVMLFLAFMQCFISPGLYGASLFLMKEEDMALTARAHKAPNAHPLTQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0T9</accession>
    <name>A0A183I0T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OB_NTP_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13351</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040158">
        <property type="protein sequence ID" value="VDP13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0T9"/>
    <dbReference type="WBParaSite" id="OFLC_0001335201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001335201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001335201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001335201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13730" checksum="9582413960B43AF0" modified="2016-09-07" version="1">MFRRTRKDGPENKNQKNWGETFISFCITAVQCNTMHLLFALTGSISQKPRSLVFDIFDLGSDIPNGCKQSHFGSLPLIFSAIFEEDERDDFYVHPYSAVIVHPSGRSILGAKRFSRGYAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1K8</accession>
    <name>A0A183I1K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2470 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040298">
        <property type="protein sequence ID" value="VDP14226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001362101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001362101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001362101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001362101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19403" checksum="920C8F600E67D817" modified="2016-09-07" version="1">MPFCSKVSLEILIAHITKDHQYGNFVHDTILHRTQQQMDSMMLFPIDCELCSFIKQIFIVAHVSSSLIPLISSIYNIVFLSLVSGCTLKITVSLPSFTYLQMYLIDLTELRYSTFMCALCVFNSKGEYGTIHRLSISMSPFCICIIANLLPSSADLPYKANSSFFATVSDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1N6</accession>
    <name>A0A183I1N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-tubulin complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040315">
        <property type="protein sequence ID" value="VDP14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1N6"/>
    <dbReference type="STRING" id="387005.A0A183I1N6"/>
    <dbReference type="WBParaSite" id="OFLC_0001364901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001364901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001364901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001364901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="693" mass="80498" checksum="94D99634AC7B7652" modified="2016-09-07" version="1">MIDETIVLLNKEKSGNRAKKFVSLMRKLRETTDAYDEIMCFLLLLSRIDDNYAGKSQVETSSRCSGSEILNAWKQTVNNYLPISAISENHTSCYEDGDDVMVQHQPCRRREKTVPIDINLSKSAESYEKIRRMIVDERGRIQPRACDPELRSLCKLKIGDMFYIISWHEYLRCIAHVLMGEESILFRKNAVGFFNFFEKNKMFLELEDINLLPRLALPFLKFANRLFYLEQFLCGSDSVKNSSMFCKIRKNTATRALLTLKLCASEQLWKFRDKVRHHANGKEECDSENIRRLLRELLDMCNVFSHFVDIVLYIQTIDARNINTLLNIFYIVKITKGRIIPAIREFCDDVLVALLRHYAECMLFWLIKGEANPSDGIFSFSKVDAETLRDTISGENESVGLEISMLITKNFLDVWLSEGKFRKLIFCCQNLKQLTSEEPKNYVTVNKLINDLSQEEIRKALDSNSLGAVESLLDFYFQKVYLSQNAIFIRCCVIDDFKQTAKLLQDVYLCDDECITEIFMRVLSEGSGSELNSNLGNCQKLWLDEMMDYLLSKNYSSILVHGFSQLTSSFDEENDLKLCYKPQFPLNIIFAPSILMNYEYLELKMMVEKSCIYSIAMMQMRMWNFIRAIRYFFHEQIRCIIVNEYQKDCEKIISALSFGSEACEIMECVGGMFGTDYQISSLQCGIIQYIKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1S5</accession>
    <name>A0A183I1S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13687</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040336">
        <property type="protein sequence ID" value="VDP14398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1S5"/>
    <dbReference type="STRING" id="387005.A0A183I1S5"/>
    <dbReference type="WBParaSite" id="OFLC_0001368801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001368801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001368801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 97 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001368801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122146" checksum="F8C2A59A2A56BA23" modified="2016-09-07" version="1">MDGGESDCTVAQAASTARLSTGDAEDRNKLFTQTSIDLSHKKLEKLSNLCQNYTKVEVINLSHNEFKFINNLSKFGACRELDVSFNVLERFSSFLPLANVLKHLDISHNVLNNCDNLAALTQLVWLNVAHNHIQVLPLLDRLIYLTYLNISNNRLNILPNLSKLPVLRILNLNGNKISTLDELHRTMPQCLQDLDIGANIIIDLREAQYLLCLKNIRSVVFAENPCVRLEGRTFCYRPYLYCCCLERLQIVDGKELSETEIIKGEELHTHAKVRRMETHAQLCAYLEKECPEDCHHSFSSDDNLFLQILKKRREYALRRKDDTTSEESAATTISPYREWLSKSASSVPNHFEYNSYNTERKENSALLTEFDDLSSLSARISTPPTSVNSNILSSAVTLSAPSVSSSTPKNITFCCTFSRKCQKSLMRNIVKDPPNRPKVYVLSESVAQNPNYRFISMENFGEISFVSARKARRYSEKEKKAASFIQLWWRNMKIRRIYRVFFLERRVQRLETLLREKSNIILNFEKQFSNLERNIEIIKASVEQQALRITDMQQFLTQFVETCNERQKYNLNKLLPVPDELQYIWTSETEIMLQWQNRQCLEKPTGYLITVDDHPCGIVKGIQKKALVTDLDPTKESVVRIQCVFNEFSGDISECLVIPSRKQVCQIFKISISFLITMIINFRVADNVRPKCYTFSVPNFASPNFIKLAILLSGIEQSIHYCEGYVQGDLNSKQPSEMPAFHSAQIDDSIREANMCAIVIDWLFIRSSRMPLVADDLDMKYGVVNQNDVADKKKRKKSKGRTLEIDFPLHSNGLIQSYESSICYDTNNQKVVSAYSADISTVENDCSDVINQLLPTVRDAMQEFLYDVGNRACEVEEVVNYLKISNIALQYKQMLNSLNNAQLCRLFEKIIFFSIIFNNNHNKISIKTINYKYFQINEPFQLSNPNTALSPSISSLSNPNNSDQLLTLLKGTLNSTSGVSIAQTKPLSAITNDFTKLPHQYLNGTETMGSQLDSAINSHQKVTGGTMVHKRLSADELLVQQNGDIFYDQNNELMDRRMLAQDARFHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I242</accession>
    <name>A0A183I242_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS13804</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040405">
        <property type="protein sequence ID" value="VDP14702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I242"/>
    <dbReference type="STRING" id="387005.A0A183I242"/>
    <dbReference type="WBParaSite" id="OFLC_0001380501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001380501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001380501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP14702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001380501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="47430" checksum="B4C9EB1ECB4227C4" modified="2016-09-07" version="1">MRDHKYSLRKRRSLSQSDDANTSSSSNHSSTTLERNGFDLEKSVHITQDSLFSGSSGWKDYRGFFNLSILLLFVSNGRLALENLIKYGVLVSPTSWIYFHLTDPWWKWPNLAMVLMSNISIFIVFVVEKLMAWKWLNNQLAFVFYLCIFSLHISLPAAVTWILQVALELSYPLYSIISLSVYVVLFLKLTSYAHVNYWYRCMNIKKNRESEKESLLIYPHNLTLQNLYYFIFAPTLCYELQFPRTNGRRKSFIMKRTAEFVCLTLIIIALCQQWVAPLLRNSVEPFTTMNFSLCIERVLKLAVPNHIIWLIFFYTIFHSLLNLIAELTEFADRQFYLDFWNAETLAVFWKTWNIPVHRWALRHIYWPMVFNGFSKMNAACAVFFVSAFFHEYLVNDIHICKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2W3</accession>
    <name>A0A183I2W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14075</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040580">
        <property type="protein sequence ID" value="VDP15429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2W3"/>
    <dbReference type="WBParaSite" id="OFLC_0001408301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001408301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001408301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057001">
        <property type="entry name" value="RYYR-CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23674">
        <property type="entry name" value="RYYR-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RYYR-CCHC" evidence="2">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001408301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28922" checksum="DA1D903BE63826A9" modified="2016-09-07" version="1">MEPRRSTTTLIKIFGRIAWGVCVCVCVHVRVANMDPIGTQNTVETINKIDALSALNTTEDYGEPVYVEAHGGKNHVIMYRSRTNPELAIEFFFRSSSKDGRSRYYRCTKCWYKYKLNRGTCATLIVRDGRIITDPENPVVPHQCEFRSLESVKANRAWIASRKRTTKSSSLEDLSDISTPCTSGLNLREVLEIWAEDSNTGMSNAESIDEKVESGGETGGTSTPSSTSSKNGRNLDDNPVWARIRERITGVDNIDLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3S8</accession>
    <name>A0A183I3S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PHD-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS14390</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the requiem/DPF family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040817">
        <property type="protein sequence ID" value="VDP16842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3S8"/>
    <dbReference type="STRING" id="387005.A0A183I3S8"/>
    <dbReference type="WBParaSite" id="OFLC_0001439801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001439801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001439801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP16842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001439801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41891" checksum="03A9725D6AC68216" modified="2016-09-07" version="1">MTDSFKMISESLYIEMMKNCSKWNSRVETERKGRYTVLDPQTGIAQHPSHHAVYELSNRYPPSNPSQYCTYGSRRWKKRKSAPTSDATEMKYILECNPAISDVINQASSAGQDPTDFQSLTAMANSSLENHFTEKRKVYIMKESGVDVEVEEASEEDPGEASDEEEWSDGRKKRKRRGAPGGSRGGRKSATTLSVNVPPTQGFTPDPKPFSCNLCGAKYKSRPGLNYHRAHVHADNVSPSTTPQPAHLMSPSIDVSTVCDLCLGDCNQNKKTMKAEQLISCHDCGRSGHPSCLKFTDNMLTSTGKYGWQCIECKSCAICGFSDNDDQLLFCDDCDRGFHLYCLRPPLPQAPEGEWSCHLCQKQFGIQASLPAISAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I479</accession>
    <name>A0A183I479_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040941">
        <property type="protein sequence ID" value="VDP17528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I479"/>
    <dbReference type="WBParaSite" id="OFLC_0001454901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001454901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001454901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001454901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13991" checksum="E54EC2F6A01698AE" modified="2016-09-07" version="1">MAMSRVLDGIHLDSLLAELKEIGTTTLPPVSRQRLITVTQNQPQESNLLSENQYSQIRRLLNSVAMDAIDATGCCGSLIFGIAFKMNFSITPFLPTSRPRNKRSSLPGIHIGGDGFDSGLAESVIRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I631</accession>
    <name>A0A183I631_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041746">
        <property type="protein sequence ID" value="VDP20780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I631"/>
    <dbReference type="WBParaSite" id="OFLC_0001520401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001520401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001520401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001520401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41128" checksum="22BC4F465544E9DF" modified="2016-09-07" version="1">MCGTAEDFDDLICLDEEDESLESTTSESLSEIKQQIHYSRFQPESYVNHREKHDNIVRHRFPDNKQMSSKCCSYEKTCNLIVVRTSAISDYISCFAIGLDFSVTVNHTNLLSTTLPIYGDDEDWPYLSGDVDEEAVRLAASLDPDATEKAKDGSQHDQRNKPNATEKMTNRWKSQYRNNDESSHCSKTPDKLDGIWSLHLWKSMYSTIFVSCVISASILEKCCRITYAPYHTVLLIFSSVILQVRQMPLKLLFTVVPQIGEKLRKSKSSVQGAREFFSLRQYWVIKPTNGSTEEEHKDWFEKISLMQKSSKDGMASTGSLHYQEYLMYKISIYRKITGNPNDSFRKGKNRLTVLILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6T6</accession>
    <name>A0A183I6T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15448</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042161">
        <property type="protein sequence ID" value="VDP21922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6T6"/>
    <dbReference type="STRING" id="387005.A0A183I6T6"/>
    <dbReference type="WBParaSite" id="OFLC_0001545901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001545901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001545901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF9">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity phosphatase catalytic" evidence="5">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP21922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001545901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22342" checksum="97A4DC978064EAF3" modified="2016-09-07" version="1">MILKVITRGGKVLIHSVQGVSRCATICLAFLTKYKFKTLRDAYMYLASIRPKVEPNIGFWRQLISFEQDVKQSTSSVKIVRDENNPSILVPDVYRKYYLCCKTKQQLAKNTVNVAEGSKQNEISRKEKEIISGQTSGTVPESTKFTAMLKSMNHTIAEASGSKSFSSQTSNQESQISRRKSSLMKKFQPVLEPLVEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7I2</accession>
    <name>A0A183I7I2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15694</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042646">
        <property type="protein sequence ID" value="VDP23275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7I2"/>
    <dbReference type="STRING" id="387005.A0A183I7I2"/>
    <dbReference type="WBParaSite" id="OFLC_0001570701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001570701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001570701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008833">
        <property type="entry name" value="Surf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34348">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34348:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05477">
        <property type="entry name" value="SURF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001570701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12999" checksum="18346DF9413AD07F" modified="2016-09-07" version="1">MTKELQCLLDQYPVFEYDERKKLRCTLTGHEIPSRFDQLDQYVKTSKFVHAWRIHEIMKEYGAYFDDIGPHEFGCKVTMKIIAKDPDDLLRHINGKRFKKELEKGMFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8L6</accession>
    <name>A0A183I8L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16078</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043971">
        <property type="protein sequence ID" value="VDP26893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8L6"/>
    <dbReference type="STRING" id="387005.A0A183I8L6"/>
    <dbReference type="WBParaSite" id="OFLC_0001609101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001609101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001609101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001609101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="13286" checksum="93FA41E3338008D1" modified="2016-09-07" version="1">MTLVEDKFRDDRARYHSRDSFWDSDRWYRDWDDWPLDWPRPGELVRRVSFLLFFLLIKHSLISNIGFEGYISNDAKVLITLTLHVYHFDVRNFYLYIPYFVSFYYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V6M8</accession>
    <name>A0A3P7V6M8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000815">
        <property type="protein sequence ID" value="VDO30257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V6M8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO30257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="121" mass="13461" checksum="15A8744DD82EFD9A" modified="2019-02-13" version="1">MQNVTGHGIDNHLCALQLLAREEVRKGLLPKMPDLFLDSTWTETMRFPLSTSQVTTPSSISDTYLCYGPVVKDGYGCSYNIQPNSIIFAPSSFKSCPTINAEHFKKSLVDSLYDIQALITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VL50</accession>
    <name>A0A3P7VL50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004958">
        <property type="protein sequence ID" value="VDO43829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="67" mass="7652" checksum="B56514305045526C" modified="2026-01-28" version="1">MLYVYACKEERSDAQYAVRSASATARLCERQHFAMDFLNALNDNDVPRAIFSIAARLAQLQYYLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VYZ1</accession>
    <name>A0A3P7VYZ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008755">
        <property type="protein sequence ID" value="VDO53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VYZ1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="225" mass="25536" checksum="730F472A415744CF" modified="2019-02-13" version="1">MKRNYDKTFPVRRNSVYRHVETGLVVYRAVGPEWRRFGTPMRKRPLTSVVLDDGVANSIVNDFQEYTERGIPYRRGYLFYGPPGSGKSSFIAALASYFGYSVCMLSLSERTLDDDRLNHLLNTPPPYSVVVLEDVDAAFGSRDDPVQSAKAYEGLTRVTFSGLLNAIDGVASADERILFMTTNHIDRLDPALIRPGRVDVKQYFGYCTETMFSEVYFLFNFTKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XDS9</accession>
    <name>A0A3P7XDS9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015145">
        <property type="protein sequence ID" value="VDO72421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XDS9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="140" mass="15850" checksum="E82F866CEEDAC39D" modified="2019-02-13" version="1">MSYWINYLSIFRVKRGAENFSGSSANAKKERLDDYGKTAAQNNRNRQTAATDSTESRNLYETGMPDTLICGGCRFVTSDFEEFREHRKSACHVNPVDGEVENEEMKWQCSMCDEVCTSGGTLIDHALDRHNIRLLKNGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XQX4</accession>
    <name>A0A3P7XQX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000422">
        <property type="protein sequence ID" value="VDO27865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0J6"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="409" mass="47220" checksum="64AC19699B397674" modified="2026-01-28" version="1">MVNDSFKSESEQMTKEKNEDKDGDLVTPWDVTASSKKGIDYDKLIAKFGCYRITKELISRFERITSQKAHPMLRRGLFFAHRDLSLILDRMEQKKPFFLYTGRGPSSGSLHLGHLIPFVFTKWLQDVFDVPLIIQITDDEKFLWKNHTLDEIKRMANENIKDIIACGFNPDTTFIFLDTEFMCPSFFTNILKIWKLVTLNQARSIFGFTGEDSMGKAAFPSIEAAPCFSSSFPLIFGGREDIPCIIPCAIDQDPYFRMCRDVAPRLKYLKPAMIYSSFLPALQGAQSKMAASDATTCIYLDDTPKQIKNKINKYAFSGGRDTIEEHRKYGGNCDIDISYQFLRYFMEDDDELENIRKRYTSGELLTGELKAIAIKEVQRVMAELQQRRKKVTDEMVKSFMIPRKLKYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z443</accession>
    <name>A0A3P7Z443_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006649">
        <property type="protein sequence ID" value="VDO47888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z443"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12873">
        <property type="entry name" value="SPRY_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000076">
        <property type="entry name" value="ATP-dependent RNA helicase DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="238" mass="26262" checksum="4455934E070BFFF2" modified="2019-02-13" version="1">MFINVADERWCLNVHDRDNNLAIDPDGLLCQSRDPKTWNGTRCTHGIVGKGKFYYEGTVTDDGLCRLGWSTANAVLDLGTDKNGFGYGGTGKKSYNKQFDNYGTSFTLGDTIGCMLDLDNATIAFSKNGEHLGKAFDIPQALRNTALYPAVVLKNAEIRFNFGETEFKHPLEGYVAVCKAQPENTVISPNGSSANESKKTMEPNAPACIIIEPTKELAEQTDGQLKTFKKYFKEPIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZH66</accession>
    <name>A0A3P7ZH66_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006964">
        <property type="protein sequence ID" value="VDO48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZH66"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO48685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="332" mass="38790" checksum="DC49869C1E52B64D" modified="2019-02-13" version="1">MSLCRNAPFAAATLILISRLIENRPSLLITKKAADLTKFNKEAEIIDDDEEVYHDYDSTIETEYTVIPVTSTLESNKEVDNGVRPCEKVSGWMHKNNIVLRDNATSYDPMVRNPLFARADKSIAAELTLLSMHYHPSVAVFASNLLNRISIRYDGDPLLDFTQMRFLDRFVFRNPKTTAMNEKIMRRKVYDPHGVRKLPVISKEYAAKNRNEIPIDERFLHRFVSMKMRMKKENESEVVHDDDDDIESVNSDEFNMLLNRFEPGERREVFDVDFSQEFSSEKKKKKKEMKGQKRPLENDTDEEEEDDVEKNNMLDADEEEELEDWSEEDTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AGU1</accession>
    <name>A0A3P8AGU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040157">
        <property type="protein sequence ID" value="VDP13517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0T6"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF156">
        <property type="entry name" value="FATTY ACID ELONGATION PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="182" mass="21074" checksum="6914B0004118E184" modified="2026-01-28" version="1">MIHSLLYEGIYRSLCYSVNPTDVAAYWAYLFFWSKVVELGDTLFIILKKKPLIFLHYYHHASVLIYTAHSGAENTGSGRAFIIMNFLVHSAMYTYFAITSYGIRLPRAISMMLTTIQIAQMFAGIGVLAYIYKIKTETNLPCQQSMANLFFGIMLYITFAVLFIHYFVSSYFRKFDKKVKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B1G5</accession>
    <name>A0A3P8B1G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014495">
        <property type="protein sequence ID" value="VDO70458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B1G5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="156" mass="17888" checksum="781C7A83C88652AD" modified="2019-02-13" version="1">MKYLENAQYKVWKSSNVLSISNSRSSYHNVRCLLRPNPLFQDQFDIKIFQSIKLAFVNDVTTIQSVNSDRELLDNFIKQQQQQQQIGFVLDSTGDVNSDDVNSNAKDFNSIPERNMWGNNNILDSTEWDGEEKSINNDGNMLTVETFMPSGTIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B2P1</accession>
    <name>A0A3P8B2P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039846">
        <property type="protein sequence ID" value="VDP11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY89"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="140" mass="15829" checksum="564EEADE698BE42D" modified="2026-01-28" version="1">MVNCSFLPILLILIVVDCDDCDDRELARLQIGIKKRADNCKIRSRKGDTLNVHYVGMLEDGTEFDSSRFRNKPFIFTLGMGQVIKGWDQGLLNMCEGEQRRLAIPSDLAYGSFGSSPKIPSDASLKFDIELLKIEREEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BZX4</accession>
    <name>A0A3P8BZX4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EML-like first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS16045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043755">
        <property type="protein sequence ID" value="VDP26411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BZX4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF50">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="3">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP26411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="136" mass="15532" checksum="9851ACE682EF2F50" modified="2019-02-13" version="1">MPRIQAHVRIWDSVTLQTLRTIGTGDASANFDRGVQCCAFSRAASMQLAIIDDSYEHTLSIWDWQKGKKIAETKSANDQVFACEFHPYSKNVLISYGKGHCNIWNIDGATLVKKPITFEVFSVNQYLNWKMNSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EQF1</accession>
    <name>A0A3P8EQF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039846">
        <property type="protein sequence ID" value="VDP11353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY92"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="363" mass="39867" checksum="C66D973A4395E0CE" modified="2026-01-28" version="1">MLLPGYLVCRLCGSHMPGVSWKRGTAALPKVCTGAEKIIPLGFASAEEPRSFGRRLKLVIRPTPEDGWYVIQQNGLLKSYLQLSKARLTAMVTATTISGFIMAPVDLSLGSLAACSFGTALLSASANTFNHLLEIPYDAQMRRTQSRLLVVHRFSCFHAIGFALSAAMTGMATLWIGCNPLTAGLGLLNALLYAGVYTPMKRYSIGCTWVGAVVGAMPPLMGYAGAMGLIDPASLVLAALLYCWQFPHFNALSWNLRADYTRAGYRVMCAVNQRLCRFTSLRYSVVILLLCSLGAPAANLTNWFFAVESLPFNGLLLYLSYKFYRHPDAKTSRTLFYYTLLHLPLIMMLMTVSKFGDSQNGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXW0</accession>
    <name>A0A183GXW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS70</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000016">
        <property type="protein sequence ID" value="VDO24401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXW0"/>
    <dbReference type="WBParaSite" id="OFLC_0000006901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000006901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000006901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO24401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000006901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20605" checksum="B6CADB0D8E9F5A36" modified="2016-09-07" version="1">MSNISHNRLEITWNRQITPTYTTGIAMSTSSVISGNSAKSTGCHKIVISPPIVPSQYNAKNAGRKKTNPVWNFFVDLKTKGLSGVRCRYCEWITNDRSPTTLKFHLKRKHDTGIGGIWNIVEERIGINQPQGRSRLVVNNRNGETAAFVIPVDTEVRPESDREQQCYPGRCRSKLQSSTLYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY84</accession>
    <name>A0A183GY84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS194</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000052">
        <property type="protein sequence ID" value="VDO24921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY84"/>
    <dbReference type="WBParaSite" id="OFLC_0000019301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000019301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000019301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000019301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11188" checksum="8E19C2E7E9EFCE28" modified="2016-09-07" version="1">MKSKDRVEFQENLAIPRKLMTSNTVTTTIPQVNFVMQENFGSVTRCEKPKFRPVVICSVNRVVLSNGDFRTIDTVCNVFFSIPSNCSIPEVNTSGARTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZG9</accession>
    <name>A0A183GZG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M protein repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS629</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000222">
        <property type="protein sequence ID" value="VDO26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZG9"/>
    <dbReference type="STRING" id="387005.A0A183GZG9"/>
    <dbReference type="WBParaSite" id="OFLC_0000062801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000062801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000062801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="873"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000062801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119277" checksum="1804A283E8C0D979" modified="2016-09-07" version="1">MSSSSDQKDDRKNRTKRQSIDSPLAVMSPSVRPQSAKLFRLSKTPAGPKLANINQVDPNIDATFLEQCSVERCRAPAVINYSDPNIEQSSIEETLQSEETVKEASTERSIVSECDDVVNITDVTSSSVADVLSPGMSNDMKSAIKIYLKSTSTCSVGSLESKAKHLVIDNVALVGQSENPDELNMDVSSNSQERTAEKNSESSIEVDLSVPVSELAVGVTEATSCSEISYDTIGMKDIFKTSFTKVSSSPYLQVENAEYLTVPKSLAKQVDEIMTHPNMPENLTLSARKNKVLTTRNLKLDNLSSPRELANYAEERAQNYSFLINEAYCDTSVFCENCYAMRIELGLFSDKFAALTANIENSAAEGNMAFVAELENLLREKQAKIVTLSSELRDLTQANDHLSKQKEIVEKDAEDYKFFFKNEMEKKSEEMSILRRKLYEAEDLIDELKQAKPKQSSEENILQAEVELGCQMEVRIKTMERQLDTAHSLHQKSQERIKQLENQLQKITEEKNQLSLKLRETVIDLENERSNQAMSDESSHVLIISLLEAKVAELGNKIDEALHVRKDETVIQKSFLFEKLTSLLEKIRSDVKNDVFAKEWKAGDVEISVMYFEKAINIICQDIPQFEMLIETVAQHEKLAKNELKQLEAMMEEAMNEKKKWEKLFTSEKSRLDSLQEVMLTQFCENKNYFSNLLQKLNEEWSKDLNELQGYTSCLKEQHLTVTSLLKSEMQKMSNKIEMLLESIEKNSNALLNNLQADDTLKDQEAKHKSLMDFVKNQLRDYEREKDTFKEMREHSEEMKQDLKKMIEQLQKVEEGIKFENAALHKNLGFERDNFARIIHVTENLIMEKDKLENKDTGIKSTISRLTGENTDFKETEKASNQQEKKIEELEHKLNLLQKENERLGKACDDADEEVGDLKQQIFELLRINAKLQAEMHGESEEAINRRLGYIEPPTIQPKINPSTLETASEINSPKQKVTDMTENLLESNLDAEIENVLVEKAELEERKKIQKFEKEDILAEATTKKISTEESPKSKAIQDQSCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZK5</accession>
    <name>A0A183GZK5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS665</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000242">
        <property type="protein sequence ID" value="VDO26619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZK5"/>
    <dbReference type="STRING" id="387005.A0A183GZK5"/>
    <dbReference type="WBParaSite" id="OFLC_0000066401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000066401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000066401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="212"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO26619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000066401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46037" checksum="B81BE9D5F19C5E2A" modified="2016-09-07" version="1">MAININRNVLDPFYRYKMPRLQAKVEGKGNGIKTVIANMTDIAKALERPPTYPTKYFGCELGAQTNFDMKNERFIVNGEHDAAKLQDILDGFIRKFVLCAACENPETTLVVKKGQIHSKCKACGNTSIIDPKHKLSTFIMKNPPKVDEKEKKENGNSGSTDNSIIDGEIPSDKELNGSASDDIDDDWAEPIDDPAGGVSAQIGKLIISRDLDKPIEERLDMLHECMLQNSKKLLNEAERLELKSKATLLLADVLFDTNVVNQIMEYRNILLRFTVNDHKAQRHLLGGIEQLISKHFDTLLPKSAHIIKALYDTDVVEEEVLLAWGEKPSKKYVKKKLCAEIISKAQPVLDWLKNAEEDESDDEDDEAIEFDDRARKVGTVELDATKKINGNAQTEKAKTEDDDEVNIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZX7</accession>
    <name>A0A183GZX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS787</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000305">
        <property type="protein sequence ID" value="VDO27066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZX7"/>
    <dbReference type="WBParaSite" id="OFLC_0000078601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000078601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000078601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000078601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18316" checksum="CA8DAAAA10CA8789" modified="2016-09-07" version="1">MVEGQNPDTTEILKKQNMRHRNGQSSIALAFNDLSDVQMIVTGRNESSDGMCRTSIYLCKPFSINRAETVNQWLVNAHNLKLHNMLEVILAKCTSESQKRANRHNTNASSSLSVYGVCWDDFQILVWLTLGLLAEELYEIALRANRSNEQNLCESVPADCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H081</accession>
    <name>A0A183H081_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS891</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000363">
        <property type="protein sequence ID" value="VDO27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H081"/>
    <dbReference type="STRING" id="387005.A0A183H081"/>
    <dbReference type="WBParaSite" id="OFLC_0000089001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000089001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000089001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07087">
        <property type="entry name" value="ALDH_F3-13-14_CALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO27472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000089001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56371" checksum="C251A4B2E0A43772" modified="2016-09-07" version="1">MATVIQHDAPYHELVEKQRVYFSTGITTKLEYRRKQLLNLKQLLSEETDVLTKAVYNDLKRSSKLTYSAELSIVFVEIDYMLDNLEQWSSPEPVKKTLLSLLDTVAIVKEPLGVVLIIAPWNYPLSLVLLPLVAAVAAGNTIVVKPSEYAPFTSAALHDLFSHFFDSRFLTVVNGGIAETTNLLKERFDYILYTGNPLTAKVIMAAAAQHLTPVTLELGGKSPVIVESDANLEVTSRRIVWGKWTNCGQTCISPDYVLVTETLKTALVNEFIQRLEEFYGSEPEKSNDYSRIINAKHFDRLSSLLARSNGQILYQGGKLNRNDLFIPPIIIAVSANDALMEEEIFGPILPIIATSGFDEAISFIRSREKPLAVYCFTRSERKVQQLYAETSSGSVTVNDVMLHFLIDTLPFGGVGQSGMGRYRGKFGFDTFTNHKALLIRSFFGDSLLAMRYPPLTDKKFKHLKLLIERRRPLPSSLPNWLIRILFLVAGVICGVALQVFHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0A9</accession>
    <name>A0A183H0A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein DDB_G0290503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS919</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000375">
        <property type="protein sequence ID" value="VDO27573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0A9"/>
    <dbReference type="STRING" id="387005.A0A183H0A9"/>
    <dbReference type="WBParaSite" id="OFLC_0000091801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000091801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000091801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="293"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="438"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO27573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000091801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60752" checksum="7A35589161683A9C" modified="2016-09-07" version="1">MEHRTLKQRDDNGPRTIKNLAAHFQNLKNNQTTAQTVESYDNLSNNLPPPVRITPYSGVKPKGMDIIRPIAFRPYASCKSEKRQAVISSSFSFHNNKKKNDFLTKRLSNSDDLKRSSQQSKDTVSNSSVPSSVSCSNRPRAIYQPSTSSELASAMVARKSSKFEAEENDYDIVPEYIEHDKFYIDVNSTTNENYSVVHSTPYCRNPSSEVLPAAASTSNITNISRDKIQQQQQNGSTAISVVAGIPSLNIIQKSSSSHQVYGSNASSGSRHSSGIHVTPSPSDSGIVDYETIIRDKENELTNIRATMEQNEEVVVKVYLEKERLWKEQLADLKQKLQASQQGENALRQQIQRCNEEREQFRVTIQNLTSDKQGLQRKCLQIERELFQLRESFDELIRNRDETICGPCRKRITCDIVATNTNNNITDKHAKPPLPTPRYSKELSSERELRDEVEELRDEVSTLRETLNEQIGLFADERKRWEEERIKILKSSNSPSNLLGLLSTNDSSSTDITSQLSRDLKILTDGKSYIVSRDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0W5</accession>
    <name>A0A183H0W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1125</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000488">
        <property type="protein sequence ID" value="VDO28349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0W5"/>
    <dbReference type="STRING" id="387005.A0A183H0W5"/>
    <dbReference type="WBParaSite" id="OFLC_0000112401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000112401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000112401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO28349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000112401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35345" checksum="DC7EAEFC5CCF8331" modified="2016-09-07" version="1">MVDIVTLQTGEKIGQWMVVEKVGEGGFGSVYKVSKGNDFYALKTESLKEKAKLLKMEVYVLKLANERKSKHFCTCLDTGIYKKCFYLVMTLLGPCLQDIRKELPGQKFSMGCALSVGIQCLEAIEELHATGFLHRSDIKPSNYATGRGNLSELRRIYILDFGMCRSYLDEHGRSRPPRKIARFRGTVRYASLSSHIRRETCRKDDIESWLYQQIEITRGALPWYSLDDKKDDVAMFKERCRFEANLQELMSGCPVEYVEILRYIDSLQFYDNPNYKKIYKLMRKAMYKLQVQEFPYDWEQSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H133</accession>
    <name>A0A183H133_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 23">Exonuclease 1</fullName>
            <ecNumber evidence="23">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">OFLC_LOCUS1193</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="23">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="23"/>
    <dbReference type="EMBL" id="UZAJ01000526">
        <property type="protein sequence ID" value="VDO28607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H133"/>
    <dbReference type="STRING" id="387005.A0A183H133"/>
    <dbReference type="WBParaSite" id="OFLC_0000119201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 23" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 23" id="KW-0228">DNA excision</keyword>
    <keyword evidence="17 23" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 23" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 23" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 23" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="12 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 23" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18 23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="25">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="24">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="VDO28607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="624" mass="70698" checksum="191827CF20074567" modified="2016-09-07" version="1">MPRIISKPPEFLYCLHGVFLIIEQSVTTLFQWRGVAISVMGIHNLLPFVKNACRQSGPQCFHFLHATQHSMHGNINEFAHQSIAVDVSCLLHRGLIGCADKVAQGCETDFYIRYVLKYVRALLAVGCHVILVFDGQMLPAKKETNSSRREKRDFHKQRGHLLMSEGRASEAYDCFKRSTSLTPKVIESAIQAFRRLNMVDVIVAPYESDAQLTFLIKAKMAQAVVTEDSDLIAFGCEKIIFKMDPSGSCIIFEQNLLPKCLCKALAENFDFDKFRRICILSGCDYLQAGLPGVGLNKAAAFFAKTNGRNLYQVLPRLPRYLNKNSLKVTKQFIEDFIRAENTFLYQIIFDPIEKRQRPLNEYPFSQQSGENGNEFYSSSQGSNDHFSYAGNIQPPEIALSFALGNIPGSSQIEQITLPENVPNWSIWSSNYKNAEMRQKKKCEEEIRKKSSCGVFMESSRPPLLRISNCLSTMDSKISANNFNNDDDDFVSFEKTKDLHKKPLLKTSKTNQIFTKIGRERTSVFSLGVTRTGNGARRNWNCDRLLKEFITTANIPQKNATKSCQFSVELPIKKSRKAAEDDYIKQDNYTGEDVIPVTSLMENPSKASRNNMFCSKYFLNKGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H147</accession>
    <name>A0A183H147_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1207</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000534">
        <property type="protein sequence ID" value="VDO28666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H147"/>
    <dbReference type="STRING" id="387005.A0A183H147"/>
    <dbReference type="WBParaSite" id="OFLC_0000120601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000120601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000120601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO28666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000120601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9886" checksum="EC850B521D13C4BF" modified="2016-09-07" version="1">MVEWKRRHNQREFFRSTNIIPKNAETLKEMFLYVVRVIKLNHFSYRVLYDYKPRNEDELELQENDVVFVVEKCDDGWFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H169</accession>
    <name>A0A183H169_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000547">
        <property type="protein sequence ID" value="VDO28760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H169"/>
    <dbReference type="WBParaSite" id="OFLC_0000122801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000122801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000122801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000122801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7640" checksum="28FFA6CFAFBF2AF7" modified="2016-09-07" version="1">MQTVFVRCYRSSKMEKMNENGPGSWLGLVGGKGECAAAAGIIMACEMNREEGEGMGWADEATTTRYDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1K7</accession>
    <name>A0A183H1K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fatty acid hydroxylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1367</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000627">
        <property type="protein sequence ID" value="VDO29272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1K7"/>
    <dbReference type="STRING" id="387005.A0A183H1K7"/>
    <dbReference type="WBParaSite" id="OFLC_0000136601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000136601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000136601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF4">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO29272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000136601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="459" mass="54576" checksum="25FB32C01E7F145B" modified="2016-09-07" version="1">MYSYKQELNLRVVFSILIVAINCPDITAMLAISINDTKKWLDHIFANTSLGQRMLYRLNLNSLRYTYYLITPSETMFETVDEVPNYTVQVSLWWLLFIILEFCSLLLLGHGDRFALNDSITSVSAGILSQCFKFGGRTIAIFIYHHIWNNFRLIENSWDSSFTWIFCLFFQDFIYYLGHQVGFFWGFHTIHHSSEYFNYTTALRQAALQDVGLAIYDVLQAFFIPPSIFLVHRYFSEIYQFTLHTTLFDNYGSLGIIFNTPSHHRVHHGRNPYCIDRNYGAVFIIWDRMFGTFEPESQLERPVYGVINQERTFNQIYLQFHTLYDLLLIKWRMKTKTGESIFRGIEKLKAIYYPPIYMPGMKVQWFFHWFSMIDHKEGVPLVENEVIRYNPAIPNWKKIYCFGHFLLLLAIFFHFEFDRGQLSYIDFNLKLAFFITTMQCLGAFFDRKFVTVIFYIFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H270</accession>
    <name>A0A183H270_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Beta-1,4-galactosyltransferase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1580</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000776">
        <property type="protein sequence ID" value="VDO30054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H270"/>
    <dbReference type="STRING" id="387005.A0A183H270"/>
    <dbReference type="WBParaSite" id="OFLC_0000157901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000157901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000157901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046525">
        <property type="term" value="F:xylosylprotein 4-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO30054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000157901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25930" checksum="A428DF088F003296" modified="2016-09-07" version="1">MFVIGSWKNYVDSDYQLFHWHVPITTDISTHMLCVLVPYRDREAELQIFAPHIDDFLNEQDILHKIIILNQTDALRFNRASLINVGWYEADRIGCDYLAMHDVDLLPLNPQLDYSYPGKGIVRHLSSPEYHPKYNYTKFVGGILLLTMFDYKLVDGMSNKYWGWGLEDDEFYLRLRDANLLSSLQRPINLTTNRSNTFRHIHDPKLRKRDFKKYGNQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2I3</accession>
    <name>A0A183H2I3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HotDog ACOT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1693</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000849">
        <property type="protein sequence ID" value="VDO30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2I3"/>
    <dbReference type="STRING" id="387005.A0A183H2I3"/>
    <dbReference type="WBParaSite" id="OFLC_0000169201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000169201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000169201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000169201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12019" checksum="2A69AE4C30009530" modified="2016-09-07" version="1">MKLYGDFFLSFPIHERSLAVVHLAVHLKNGQSVYFTAVNVQHIAPNPPATTLTAFFTFYQTDAFAKTLLYSEMPIIANRMRVENHLNNTKEENQLTDNLAYSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H301</accession>
    <name>A0A183H301_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1860</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000967">
        <property type="protein sequence ID" value="VDO31035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H301"/>
    <dbReference type="STRING" id="387005.A0A183H301"/>
    <dbReference type="WBParaSite" id="OFLC_0000186001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000186001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000186001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO31035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000186001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13873" checksum="0A36C3EACDB74B47" modified="2016-09-07" version="1">MIRFILIQNRAGKTRLAKWYMNFDNDEKQKLIEEVHACVTVRDAKHTNFVEFRSFKIVYRRYAGLYFCICVDILDNNLYYLEAIHNFVEVLNEYFHNVCELDLVFNFYKQRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H396</accession>
    <name>A0A183H396_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1956</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001042">
        <property type="protein sequence ID" value="VDO31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H396"/>
    <dbReference type="STRING" id="387005.A0A183H396"/>
    <dbReference type="WBParaSite" id="OFLC_0000195501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000195501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000195501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000017">
        <property type="entry name" value="Phosphatidylinositol-binding clathrin assembly protein LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000195501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29574" checksum="33A59747E32624B9" modified="2016-09-07" version="1">MQTIEKALHQPMPFTTGGQTITDRLTAAKHSLAGSQLGKTICKATTEELMAPKRKHLDYLLHCTQEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLGSFLDKNSAQGHSPMDYTRSSTKHWASLDSVLVGYDMSQHVRRYGKYISEKIYTYRLCAFDFCKVKRGREDGLLRTMNADKLLKTLPILQNQIDALLEFQVSFFFFSRCFLLIRLFPDINSIFSRAEFILHCPHNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Q8</accession>
    <name>A0A183H3Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MEIS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001155">
        <property type="protein sequence ID" value="VDO31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Q8"/>
    <dbReference type="STRING" id="387005.A0A183H3Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0000211701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000211701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000211701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000211701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="6858" checksum="DE1977C4AD383A8F" modified="2016-09-07" version="1">MFPSNPYAAGITHPAFTNPAALTGHMFMPGPMSHMMAPYSAAQTQMGANVWMESLMPGHMSMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3W8</accession>
    <name>A0A183H3W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001197">
        <property type="protein sequence ID" value="VDO32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3W8"/>
    <dbReference type="STRING" id="387005.A0A183H3W8"/>
    <dbReference type="WBParaSite" id="OFLC_0000217701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000217701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000217701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF131">
        <property type="entry name" value="COPINE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000217701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35922" checksum="E909959118E23C61" modified="2016-09-07" version="1">VLCYSRDDHRRCSIIGQFTTTSDVLFECAKERKALCLQVGLESNKKTNGIIEVVKCNEITLYSFLDYITNGSQSYAAFGFGARIPPYFRKSQQFCLNLETDPNCQGIDGLINAFWKANAQVQPSTNAHFAHIIYHLSKQATIFASKTPLSIIFIATEDDCAEMERLGLSAGRISYQNRRAERDMLQFVALRKFRNKIPKDANFWELLTERALQRIPWQMIDWLMKNGHVPQDFKHYACLPKQVEGSSGTSGCGLANQQKTINEAESFSDQSIDDLDEAEHASTSNYYNVKEHTGKQRLYLSANFRKPRISNFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H499</accession>
    <name>A0A183H499_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidored_FMN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2311</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001300">
        <property type="protein sequence ID" value="VDO32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H499"/>
    <dbReference type="STRING" id="387005.A0A183H499"/>
    <dbReference type="WBParaSite" id="OFLC_0000230801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000230801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000230801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000230801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="985" mass="110638" checksum="FF4260D9A9F2E82C" modified="2016-09-07" version="1">MPGKYAADLPHKTDFNINKLTRKEISELINDYAYAACYAQQCGFNGVEITCAYFFALGQLITSGANTRKDEFGGNLDNRAKILFKIIQAIRMKICKPSCFVIGLKLFCGNFEPDYNDDAFGEFVHNVEKTGFDYIAITGGHYNLIKNLKRNDDPKNCEYFYQKFVLAIRNNLTRTKLFMNGGFVTLPEMVAAVRDGWAAGISLARSAAAEPDLPKRLFAGEVKGATKSLFDPLDYSIEQNFAGSQLWQHAYLLTVMDASNPDHIEQFKRDLHLHEKQKSVGELVIGYPKTIVNPELLDEGMLKRIYQSSRGIESTAEEHPGECKLTKDIVNSESELIEEETHHVVKKQLDYGALGDLQENIVEDSILKVMKRHENLPDGGVDVIEETIEKVTLTQSDFLESSQRESAQLPKLEAEANDSSKHANGVLDTVAEALDASFNDVKKVLESACKKDVKLVDEVVKDVTEELRKEGEEANARSEICKDEHHEETLCAIQQSETMETTEVISGLSDDDKPIIFGIVEKTKDTNYTLKPSEQGNPENLGTENEQYLVTERECPFGDENYTIGENVVKEVMQKKICGVSDDMRTSFMEAPMTKLSPQPELFPGKDGEQFTDPPKFQDTEGHKDEPLQDHSKKYVAEAHAHEGITEAYIPKNIAEDRIREGADEYFLDRTDFTRDLPGNYFHEDINNVMKDDSRAEANDMTADDHVGECPIAKDLKDQHIESFFEGGTVKPKWDELSCDDDPYKVSSTTYSTLFGSTLTGGNGESVVYEGYYDKRPPTGQSPEKTYHSEIYGIPSDESKVIKNAENLSNEKVHINQIQSEFDAEKSIMDNNISTKRQGLTGFISSALPDSVQNLISSTRNKFDEMLGDGDGKHQPDMQFTMKTEEMTVDDGRKYEVHTESCSVTNLGHRLSSDFENGKAFLANDSNRFMMYGDDLIGGSTDLHHSTETTITTMTSEDDKESKKHRDGLFGDKKSTDELDFEFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4V7</accession>
    <name>A0A183H4V7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS2517</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001462">
        <property type="protein sequence ID" value="VDO33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4V7"/>
    <dbReference type="STRING" id="387005.A0A183H4V7"/>
    <dbReference type="WBParaSite" id="OFLC_0000251601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000251601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000251601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="15">
        <location>
            <begin position="96"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000251601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22390" checksum="20B7E3F8A6D9A71E" modified="2016-09-07" version="1">MSFQHDAQMNYYGTRLATCSSDNLIKIFEVHYITLICNYDGLLQLKPSGQTYPSAELNGHTGPVWQVCWAHPKFDNVLASCSYDKRVIIWKEISGKWQRIYEWSHHDASVNSISWAPHQYGLTLACASTDTAISILSFNKAKIWTHQIIAKAHEQGCNAVSWAPTVYSTSLIHSDGPLIRKRMVSGGNDNFVKIWSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5F6</accession>
    <name>A0A183H5F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001625">
        <property type="protein sequence ID" value="VDO33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5F6"/>
    <dbReference type="STRING" id="387005.A0A183H5F6"/>
    <dbReference type="WBParaSite" id="OFLC_0000271501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000271501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000271501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042508">
        <property type="entry name" value="FBXW5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995:SF17">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000271501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37776" checksum="D33306D81F84062C" modified="2016-09-07" version="1">MSPVFRILNRGGTYCQMIKLGRFVPSRLRGILVLAEEAAFEHKTLISKVNELVSGELSDNERRNEMKKRIEEISSDWGTECLSCKNWHLVKENGSVNDSSSVTYAACCPCFCHENDHRLLMYATGDNEYSPPHRIAFKIVDGNMIAEKINPEMESWPKQEERSSSRHHRQQEFEEAQLSAVMSMVDFPDHIIDLKAYIMGMTLSLDQKYLYVNVTHDNYGGSSQFAYLAEICVINLSTMIIEKSYIGHFATCVERFGCSVGGHYVASASIDGGRIWSREYHCVIGELPHVGGAAAVALNPVDGTMAVSVGKTDGRIKIWRSKKFLHRYTVPNDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5K5</accession>
    <name>A0A183H5K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BrkDBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2765</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001668">
        <property type="protein sequence ID" value="VDO34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5K5"/>
    <dbReference type="WBParaSite" id="OFLC_0000276401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000276401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000276401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000276401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13644" checksum="86310F078C0CFAB1" modified="2016-09-07" version="1">MPIKSGRNSNSNMMIGNDDDNCGTESVVAQKGRKLKQYVLEEKLDIIDYAKIIGNRAAGREFNVAESSIREWRKNEQRLRSMFETTPERSRLDGGGRRPVSEDLEKSLTKKVDWKELLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5M2</accession>
    <name>A0A183H5M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CSRNP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2782</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001684">
        <property type="protein sequence ID" value="VDO34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5M2"/>
    <dbReference type="STRING" id="387005.A0A183H5M2"/>
    <dbReference type="WBParaSite" id="OFLC_0000278101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000278101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000278101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000278101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24092" checksum="37A8908A7633B919" modified="2016-09-07" version="1">MDAQYSSCDDNSKNTSGGNDINNNASNNERRKKGVRFENVKIYFFERTQGFDVVPSSGGIALGMQKKHFDIREFALCNNMTDDDIAKSQDCKLSAKGSVEQVNTIRTRCKRGYYNTFYENATAKRPRIGDDTTGQVLSKMKAITNIESRESKTSERISSISIPDGVSEHIDNVKEENEIDDIYIVKKYFRPLSRRIRLLKLRNAGFKKFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5U0</accession>
    <name>A0A183H5U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2854</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001746">
        <property type="protein sequence ID" value="VDO34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5U0"/>
    <dbReference type="STRING" id="387005.A0A183H5U0"/>
    <dbReference type="WBParaSite" id="OFLC_0000285001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000285001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000285001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000285001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41942" checksum="778DEE4658FCC641" modified="2016-09-07" version="1">MYHQQQDIVRDNYITLAAHFTADQLYKAHRLQVNELLGVPVIQSVIDGLDFKRATLNSSLVRDIANRLDAQFAKYFNLLTETKKYILNNSHPGWITSQDYRSMMECARITSGHLSYEEQFGTRVNMTSACLMSGKQPSKFLHYAEKNLTSVLHTNALDSAIRWQYIIDANGPHIEYPAHTFPVHKRRHWSPFLAAALPQKRRVVILIDAGTLLSDVHLAKAKSVAKILLDGAIPGDRYMVMVSNGTDNAKACKNQNFLDVTSEQIAVMTTFIEAFDRSNQKAYSHSSAIQMACRLFVKEEIIDREDGRNEFYHNILFYISRGVMSELGEAASVLSAVAEIFLEANIRVKINTLALSDGIDTFWRLKHELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Q9</accession>
    <name>A0A183H6Q9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3171</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002042">
        <property type="protein sequence ID" value="VDO35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Q9"/>
    <dbReference type="STRING" id="387005.A0A183H6Q9"/>
    <dbReference type="WBParaSite" id="OFLC_0000317001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000317001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000317001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000317001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10996" checksum="71242ACAECA76D93" modified="2016-09-07" version="1">MDETSAACEDLRYFERRLTEVIQSMQPAATRWRLVLLIAFGCTLWSAYFWLKDPSIRNITLVESLQNHLVFSACVPSLLFLFGFIGIHNRAVAPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6W9</accession>
    <name>A0A183H6W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002095">
        <property type="protein sequence ID" value="VDO35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6W9"/>
    <dbReference type="WBParaSite" id="OFLC_0000323001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000323001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000323001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000323001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8152" checksum="D17F42B9713AF6FF" modified="2016-09-07" version="1">MLAAKEQQRQSETRRILGYSEHRCRSLERETSGPTHIKLDQYDGQIQEESAAKEQTKLNNPRKYSILSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H716</accession>
    <name>A0A183H716_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3278</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002144">
        <property type="protein sequence ID" value="VDO35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H716"/>
    <dbReference type="STRING" id="387005.A0A183H716"/>
    <dbReference type="WBParaSite" id="OFLC_0000327701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000327701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000327701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000327701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="670" mass="76393" checksum="D9A304A1BEC485B7" modified="2016-09-07" version="1">EIRRLAGSVLSRKALPVPKSIKDEIIPKTITSSRKAIVEDEDEAEIEVEREARQLTSSEQWWRVRALLDMIEMLDKLMVYACRGAIFQLFTVSQLSQQFLMTNQASCMNWLSRLYLPMMAVAYTSNNFAQVVRLGSCSLRGIGKRIEEKGKKDGGDEKGEIDSVAHTCISWMVKALIDLSRPQAILGLYAWIKKIYGKQYIWIKCAAEMAAGRIEPSLIGLQECLRNENLPENIQKTIRQLIIFGLEVLRNTDEIDIFWRTLYGILDPKSDEIPDGFEEFTWKRMKSLTTFDNYLKNESVMSIPWDIRNNLIHTELKLIDMARDRSRDCKDNKADIVELTRQLSEDARILMLADTGLQIFTRASALHLLATAVKDSRKPYHKQSITANVIDPSFLFDWKNGLPLQRLVIGQQLSSWLQYTQTRENGGCSSLRIISNEAAFYLEMARLARKTRNYRLAEKHIKIHYNKRLPTLDNFQLNILRGMQGNWINGPTDKENRLINNVSMQLPMQQRLYNFENLMSSYGLSKIMWAISKTADTDRARTFLQGKAFSLLMNAVADEVDRLMYKSNLMFNGTPTVAPDALIAVLTQQLNHATIEDSAVLSIGPNIAANNQQQLEQNKISAKAIIQLARWLQMESSLLPVAMSYSVRIVFHVFGVEQSQLPLVGPSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H763</accession>
    <name>A0A183H763_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3325</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002192">
        <property type="protein sequence ID" value="VDO36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H763"/>
    <dbReference type="WBParaSite" id="OFLC_0000332401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000332401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000332401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039952">
        <property type="entry name" value="Aex-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21643:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21643">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000332401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="22012" checksum="365DA64FA1BB0A38" modified="2016-09-07" version="1">MASDHMYFYDIFMVTYCVLPVTSSLIVSGYLYQLTHEKRHSPVSIGQSQKFKNKMKSLVFIFATTAWTSFSLLPYRIFNICRMHLFEWNSLDCDTQSKMNWLAYVLLYLLFLNPIINPLITALIYAPYRITLKRFLFSIPDRNRSLYNFRENQTDLSYTCVCNRRSRGYRESEITLDDHEMVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7F9</accession>
    <name>A0A183H7F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SLED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3421</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002276">
        <property type="protein sequence ID" value="VDO36439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7F9"/>
    <dbReference type="STRING" id="387005.A0A183H7F9"/>
    <dbReference type="WBParaSite" id="OFLC_0000342001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000342001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000342001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF132">
        <property type="entry name" value="POLYCOMB PROTEIN SCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="194"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SLED" evidence="7">
        <location>
            <begin position="449"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO36439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000342001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59275" checksum="BC6AE927055E363F" modified="2016-09-07" version="1">MEEVIREEDSKQEIFITEKDEDVEDEQRLVISDDKHTESPFSSTNEDALDNSPLNSQKLVKSDDEKDIFVVQPLQKEIASKNTANIAFSWQEYLEKTGTIAAPEDCFYQDPVPPRNKFIVGKKVEVPDPRGKEVQCLATVVAIHSFWVCLRLDGEDGSNDHWLICDDERIKPVGDCERNGLVLQPPFGFMYNLASFHKFIENQLKPAADGSIPTASSESFKPIPFKYHPRRNKFQIGMKCEAIDRKNFNGRPCPATVVDIKGDYLTISYDGWNKAYDSRERYDSRFIFPVGWSAKCGLEVQPPNHVKAKILKRKSVNTKNGSQRAGNRKRKRTFSVPNPHRNTSDDSCSSHLLDIIEQVAKQTYTVEANSVSSALDQQIVTSGVDGVATLDDRIEPRARKTVPSPVLPEGPVVWQSRRTVSSLDGVQNTLNAPDIVLTTTDVRPEIHKMVVYLNRGCRCSPVLSASLVHKLPEKFGPGTLHHILRETLQQIVNCAVDPSFVFKKIDPGPVRILSITGKIDQDLVNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7J4</accession>
    <name>A0A183H7J4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3456</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002311">
        <property type="protein sequence ID" value="VDO36553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7J4"/>
    <dbReference type="STRING" id="387005.A0A183H7J4"/>
    <dbReference type="WBParaSite" id="OFLC_0000345501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000345501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000345501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039846">
        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000345501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28083" checksum="362610BA338543A4" modified="2016-09-07" version="1">MQFNLGINFKMKRKKKEKCMENKSEWSLRKRQGFQLLDPTGYQVPTCSHGPCLLFKRRTLQTTEKFFACAVYRSQKRCPFRLDIRSEIVSDNLRENSDVLNIATTSFCYATIRKKVNLLRARNEKIYYCVICNDVFSLPHVHPMKGPLGISSLRRPSQLFSAHMQNDSESQYWFAEESLTVIVNAIEKSNCDGILCIGTPTIFEHFQSHKLLRQKTKSFLLDIDTRFVRFFLKPLFLQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8R4</accession>
    <name>A0A183H8R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLDND1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3876</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002743">
        <property type="protein sequence ID" value="VDO38058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8R4"/>
    <dbReference type="STRING" id="387005.A0A183H8R4"/>
    <dbReference type="WBParaSite" id="OFLC_0000387501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000387501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000387501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000387501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17401" checksum="698095409234ABE0" modified="2016-09-07" version="1">MQSTKYNLQELPSPGGFNLRLTVPKKHYSVQRNDSLQYIITPVFDKAMMRKKTPSSPATVLTVAGLFVVGITLILSGIIVLCQQSEQSFRICGSLFIGFGMLMLLVCTVLQRKNIIKFIGDLNQDLYFFYMSDSYMWKLMFVNRSELPESHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9M5</accession>
    <name>A0A183H9M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4186</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003082">
        <property type="protein sequence ID" value="VDO39216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9M5"/>
    <dbReference type="WBParaSite" id="OFLC_0000418601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000418601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000418601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000418601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10575" checksum="DE0CCC575EFD0D29" modified="2016-09-07" version="1">MELHDITTKTANLSFSGAKKDSSELYWKASRRLFQLLFAQRGNAHLLTYCPVLKSQFSVCYLDANRLVISRNTSCLQKQKCQRDNKRMTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA56</accession>
    <name>A0A183HA56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4366</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003281">
        <property type="protein sequence ID" value="VDO39765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA56"/>
    <dbReference type="STRING" id="387005.A0A183HA56"/>
    <dbReference type="WBParaSite" id="OFLC_0000436701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000436701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000436701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="213"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO39765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000436701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50638" checksum="5914B5B476689290" modified="2016-09-07" version="1">CKVADAGIRLKKKEWTSCYLFLSSAHIIFYKDERSAEKSGRHYEAPLGMCDLRGATVMWANEKDKRRKHIFQLELTDGTTYYFSTANTQDVNGWFHAMRQVVSKLPRPDAYPTPVLERGLTTIGLMRNPSNLSYSSRSLSTGQTRRSFKKSKALGKGSDIAVASDEKKRADIEETRLTRESIIEKLKRFFRSRPSIESLKEKGIYKPEPVFGSTLAAICHHEQTIVPRFIQLVTEVVESKGLDTDGLYRVSGNLSSIQRIRCQVDQEKYVALLAEDDVHVLTGALKLFFRELSEPIFPVNLAKDFIYANRLPKGEGKLKAFDDLLNKLPLVNRETLKVLFGHLIRVANHADKNRMEIHNLAIMFGPSLFSSGTNEIHDDSKKRSNSKKGKVANKKSKEKPTGVQSNSHLAYNMIMQGQIVEYLLKEFKRFPSMQPQQQSSVYRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA98</accession>
    <name>A0A183HA98_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS4409</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01003330">
        <property type="protein sequence ID" value="VDO39916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA98"/>
    <dbReference type="STRING" id="387005.A0A183HA98"/>
    <dbReference type="WBParaSite" id="OFLC_0000440901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000440901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000440901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="123"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO39916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000440901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33893" checksum="B7D734F961913D20" modified="2016-09-07" version="1">MESNISDIVYEQIKNNPPIDRRVLSIQSHVVHGYAGNKCSVFPMQLHGYEVDPINSVHFSNHSAYKIMKGQVLDGAQLSDIYEGLKLNEINNYSHILTGTTLHISDFSISPIGYCRDASFLHEVINIIKDLKQKNPNILFYCDPVLGDNGRYYVPKELMPIYRDILIPMADLITPNVFELSELSGLSINNEQECLEAINLMHESGVKTVVVSSGLETPTTKFCYGSVYKGPNEPSLQYRFDIPILPGQFVGTGDIFISLLLVWMDKLNGDIVTAIQNVIATLQRILQRTVNKAYSKILVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC28</accession>
    <name>A0A183HC28_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5041</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004135">
        <property type="protein sequence ID" value="VDO41862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC28"/>
    <dbReference type="STRING" id="387005.A0A183HC28"/>
    <dbReference type="WBParaSite" id="OFLC_0000503901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000503901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000503901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000503901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9980" checksum="8565EC3B97999E1B" modified="2016-09-07" version="1">MVSADIQWQIIRKTSSFLRRQRGIPKHFSREPFNLKGVNSIRFNGLVHRKGMNIQAAPEDEEGIVVTTKKRGEFFYFSNRKFSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDM7</accession>
    <name>A0A183HDM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004879">
        <property type="protein sequence ID" value="VDO43660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDM7"/>
    <dbReference type="STRING" id="387005.A0A183HDM7"/>
    <dbReference type="WBParaSite" id="OFLC_0000558801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000558801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000558801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000558801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22298" checksum="F58EBC91A3E4CE72" modified="2016-09-07" version="1">MSKATSELEKKITDLEKCIESHEAVLHDVLEQYKVKEREMSQALANSKFEIAQLNETVDRIESEHNAELKRIHHEYRETEKKAIIQKKTEIENYDDTINTLRKNKEYLEKSLAVAEEEMKELSLRCENVTFENDKLRLQLDEEKERCEKEMASLRQQLNAIEERYIEEITEWERICAEVGFILSDGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDV0</accession>
    <name>A0A183HDV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5664</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004987">
        <property type="protein sequence ID" value="VDO43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDV0"/>
    <dbReference type="STRING" id="387005.A0A183HDV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000566101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000566101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000566101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000566101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29111" checksum="78913A441A7F3E4F" modified="2016-09-07" version="1">MLLPCLLCDLQMDGEQTGDIVKSGFQTNSQLREHLVDCHAKFVARALLAPNVTNKTHFWLLTNIAYHCENVGDDFLHDTFLETAALESTKQSSVAPDFFQVSQDDDVDKSYLNSQKRKSSQDDDSEKVDLQPIAKRSTNFMTEAEFSEIATAISNHLNQDQQLQKSISLQNGSKAIRKSNCQVCHVDVCTTARQRHVYQFHLRISNLFQCSDCDYTNNNSIWEMRKHCTTVHQGNAYPISNEEAHKREIQVIIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE59</accession>
    <name>A0A183HE59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5773</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005141">
        <property type="protein sequence ID" value="VDO44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE59"/>
    <dbReference type="STRING" id="387005.A0A183HE59"/>
    <dbReference type="WBParaSite" id="OFLC_0000577001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000577001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000577001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000577001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23856" checksum="6E20BDBEA8A6DEA8" modified="2016-09-07" version="1">MLRRLQTEKNVPWLFSRRLIEDFITSRHVLRPHLNQQLRSYLLNMNLKKMTVEEKEELRDLVIKIIDIFVEISRFSEVKHLQKIQKKLEPDFIADMSLMMIKLDESERAWKFLSLLLDEEAKQGEAATVSSERSPNYEIMDLLMQEALNEGNWYNASCCLQIMALYALSKNLKLEVDRINKHCNLTSIQRKILENFADIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEL1</accession>
    <name>A0A183HEL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5923</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005362">
        <property type="protein sequence ID" value="VDO44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEL1"/>
    <dbReference type="STRING" id="387005.A0A183HEL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000592201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000592201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000592201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17060">
        <property type="entry name" value="Ubl_RB1CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000592201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19636" checksum="4C4F5D6E279E28A1" modified="2016-09-07" version="1">MRARIGTVIIRLLFLQPVINVFEMKCCMQQIQHTPFLPSVSGGAAMRFSILWFCSFCFEIVDLLDSALWFIYFSQIMNGYAAFPLSGLMFYVFYVNEGSLQALEVSVALGSVYKLQCVIEEITRVPIAEQALLVSGGEGLQSEKQVSHYQGAGTESNPLFLFRKLYKEDIQCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFT5</accession>
    <name>A0A183HFT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6347</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005985">
        <property type="protein sequence ID" value="VDO46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFT5"/>
    <dbReference type="STRING" id="387005.A0A183HFT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000634601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000634601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000634601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000634601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28489" checksum="284CF485A14274C4" modified="2016-09-07" version="1">MRNSDWSSHNPQTHHHHRYNQTESLSPSSSGHTAPLLPHQYSKSGWTYGLDPCGAECSKNSKGVHSNLRIAAKVKTVSLAASKIPVSIRHNDLDYTTGSSSITSSTTVSENLHRELIGVPFITTTSDITSDGSSIADVKQSTGTSTNAHYLCANDSVTSVRRAASFTFSPKGHLDRVNQRSQLHGVEPKRRFARFAKTLDFIRSKMDSCSTSTLYPSKEEIMLWQDSFERLLNHKCMSISIFGQSIIDFYIFFQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH02</accession>
    <name>A0A183HH02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6764</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006623">
        <property type="protein sequence ID" value="VDO47845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH02"/>
    <dbReference type="STRING" id="387005.A0A183HH02"/>
    <dbReference type="WBParaSite" id="OFLC_0000676301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000676301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000676301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000676301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22834" checksum="8C1DD29A374B439C" modified="2016-09-07" version="1">MDLEEDDGMESFDINERDLEFALNPGYRRGLSKNQQLYGIWADREESDSEDVHAGFGSKGSKKQSKNYSAPVTFVSGGVKHGNKIEKENKDDDDDSVDDEPISVVKPRRASRRQAGANVFAGLRLSSTHSVVDPDKFADWAKHSKSDVIMKMMRKMGYVPGQGLGANKQGIVEPIQAVLRPGRAAVGAYGRESKGPNFGESAAETQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHE2</accession>
    <name>A0A183HHE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6906</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006864">
        <property type="protein sequence ID" value="VDO48366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHE2"/>
    <dbReference type="STRING" id="387005.A0A183HHE2"/>
    <dbReference type="WBParaSite" id="OFLC_0000690301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000690301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000690301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF382">
        <property type="entry name" value="CALPAIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO48366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000690301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27050" checksum="399E2C0043501F2C" modified="2016-09-07" version="1">MTYISQLWVSLIEKALAKMLGSYAKLPAGRTLEGLAILTGAPCTLLDLESYTDYDLVWAHLLSMRTIISREAGFIMGCSCGGGRRYVDEAEFRRVEKICICFRVVRLRNPWGAFTWNGPWCDTWPGWDESSRRILLPDGPEAGAFWMPFADFIQRFDSVEVAKVRSAQGWKELRVDCSIPQFWGKENILGFQLQIEEPTELAITVYQKGSRDRCDSDIMVLLHKNVASSTRIGELIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ60</accession>
    <name>A0A183HJ60_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">OFLC_LOCUS7523</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007912">
        <property type="protein sequence ID" value="VDO51372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ60"/>
    <dbReference type="STRING" id="387005.A0A183HJ60"/>
    <dbReference type="WBParaSite" id="OFLC_0000752101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000752101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000752101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF25">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO51372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000752101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12257" checksum="B583437BF6B03A34" modified="2016-09-07" version="1">MDLIPNRLDDREHRQIGYYQWVPFVLAIAAIMFHMPSTIWRILSTQSGLNMSLVIQLASQDQNVDPLIRDHSVEVLTRHIDDALKYQRDYGSRNKSVSILCQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKC8</accession>
    <name>A0A183HKC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7938</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008631">
        <property type="protein sequence ID" value="VDO53259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000793901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000793901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000793901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000793901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17203" checksum="104D71CD12CF9FA3" modified="2016-09-07" version="1">MIFCHICWDNIFAKRAPWILLRAIIGISQKQTLQLCGSRVTWSACFELMCAYEYSVVFILVYIHIYTYITHTTHLHYEANDMTSTVGGRMDLANSNGKIGRRGNQNATTEKQSSRKRNNAKRGGVKRRMASLAYHQQQYMLMRGAHPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKE0</accession>
    <name>A0A183HKE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA_edit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7953</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008656">
        <property type="protein sequence ID" value="VDO53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKE0"/>
    <dbReference type="STRING" id="387005.A0A183HKE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000795101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000795101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000795101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000795101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16740" checksum="188E4E5E64FF4760" modified="2016-09-07" version="1">MSNCVFEKFDRLLYFIIIQLFIVGKICCWELGNRMDDQKQLFLFAFPVPSNEDHLIDRIKEASSARNQHGAVSTAALANIDADSIAQLAVGPNHVAFLFKCGRVARLKYTLTTATREENTGDEKSSSGTSGGAGSGSSGSGSGPTTGGSSGSSAGAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKY8</accession>
    <name>A0A183HKY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8150</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008992">
        <property type="protein sequence ID" value="VDO54255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKY8"/>
    <dbReference type="STRING" id="387005.A0A183HKY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000814901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000814901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000814901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="89"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO54255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000814901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32631" checksum="275D5DDFD92AF99B" modified="2016-09-07" version="1">MNYPAPEVVMKENDVGIVIAGVTIWLSDIEKVPLNHAEIILGRPLQRIALYILIKALPEHVETRPLYSVINPDSECGKLEMFVDLFPHSLGSIPPPLNISPRRPYKFQLRVAVWSVRNVILTKRTMGRPAADIYLKVFLNGSEKEEKTDVHYQSLDGYGSFNWRFVFDFDFDIWEKKIAWYRKKRRFSKKSLLLTDPILFVQIWDNNKFRKDDYIGQLALDLLSFDEAQMDADEMYNVDYARENRNCCACCTCCAKCCSYFCGRKKFERKKKIIPLPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKZ4</accession>
    <name>A0A183HKZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8153</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008999">
        <property type="protein sequence ID" value="VDO54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000815501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000815501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000815501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000815501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23210" checksum="0135B09304533E11" modified="2016-09-07" version="1">MSAVSLTGTGKYGSMEFRFTAITGRQLVNFASSALSIKAASQHSFIHYTTSERKMARMGTARGTRPAAAAAAAAISIHNSTFESIRYPPHISQLTSQQRHERSERNETHRFSLSLLSSSSLLHPLMARLRRRQGSSGMTIEGAATATAVCVSRCYCGCCCCCCLFRHQIPYKHCSFPSLSPGIIFWLGLFQKFERVKTCISPLVCYVIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL62</accession>
    <name>A0A183HL62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosinase_Cu-bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8224</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009132">
        <property type="protein sequence ID" value="VDO54647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL62"/>
    <dbReference type="STRING" id="387005.A0A183HL62"/>
    <dbReference type="WBParaSite" id="OFLC_0000822301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000822301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000822301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000822301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9277" checksum="F01035F6D92AD826" modified="2016-09-07" version="1">MKPPEQSTSDPIFYSHHAFVDFIWELWRQDVQPAWIRETAYAPDIPACADPQHFSYSLMRPFFTLYNRDEHSSMEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL84</accession>
    <name>A0A183HL84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8246</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009168">
        <property type="protein sequence ID" value="VDO54762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL84"/>
    <dbReference type="STRING" id="387005.A0A183HL84"/>
    <dbReference type="WBParaSite" id="OFLC_0000824501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000824501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000824501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000824501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15059" checksum="17F8EB2C1D822B4A" modified="2016-09-07" version="1">MPPMWAQLLQSAQISKQEQQQNPQAVLDALKYYTQADSSQQKWLQPSSFEGCSLIHRTNVEQQRQHQQRDLNTATSLISLYSSSSLHRGHCQNENENGSQGLIHNQHLLTKSQPNTYQRGKSVIFAAHYLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLV6</accession>
    <name>A0A183HLV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009601">
        <property type="protein sequence ID" value="VDO55808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLV6"/>
    <dbReference type="STRING" id="387005.A0A183HLV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000846701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000846701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000846701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000846701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20141" checksum="91879BD63D7047EF" modified="2016-09-07" version="1">MVFTVNNAYYRKLNGTANADPTGAAFELSSLIQVPPANSNTFMQHHHSGSYAQYSPRPSTEPSVEPYQIPEIQSSQVAVKSLKSGSSMVERQNFEEEIRTIAPFDHPNVVRLLGVCYFDTQQLSAVFEYMVHGDLHDFLRLRAPKTGFVLIFQKFSINFRNFFQFQKLKCLFMLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM50</accession>
    <name>A0A183HM50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8564</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009804">
        <property type="protein sequence ID" value="VDO56284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM50"/>
    <dbReference type="STRING" id="387005.A0A183HM50"/>
    <dbReference type="WBParaSite" id="OFLC_0000856101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000856101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000856101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO56284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000856101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11932" checksum="3EDCC58EA221A495" modified="2016-09-07" version="1">MPWGFTIQPWMAAAAMALSSVSVVASSLLLKLYRKPTQQSLSCVEFYNHQARLAMGDWPVVVHRGLDNFAVRRTLSKLSFSSVISTISSIFGSQQSINRISPLDRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM75</accession>
    <name>A0A183HM75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009828">
        <property type="protein sequence ID" value="VDO56350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM75"/>
    <dbReference type="WBParaSite" id="OFLC_0000858601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000858601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000858601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000858601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9100" checksum="1AFC18E4D4DD27F9" modified="2016-09-07" version="1">MLLVTVAAWRYPKNSLSEQPSIEEGSNNEIHPLGGSCPDLSNSQLLLWDNYLFDTIMNETNNMINEETTNKLTVDPMQQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN72</accession>
    <name>A0A183HN72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ufd2P_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8936</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010513">
        <property type="protein sequence ID" value="VDO58097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN72"/>
    <dbReference type="STRING" id="387005.A0A183HN72"/>
    <dbReference type="WBParaSite" id="OFLC_0000893301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000893301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000893301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="6">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO58097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000893301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19123" checksum="73DE349ACA749D38" modified="2016-09-07" version="1">MSCQQMSNKYNREVAVYPYSLLKFFVSVKTSSNKRPIADLLVSRTDFITEVYSFLEGHDFARLCYLGPFFEYSTAPADNGSLSIYMPFFDCSQLPEDEQKPMLYNVYQNDLTLVRRHLHQIMHQLLANTSSRNRTLDFIARVLSVNIKRRQMNQNLIISWLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ30</accession>
    <name>A0A183HQ30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MMS1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9589</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011920">
        <property type="protein sequence ID" value="VDO61710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ30"/>
    <dbReference type="STRING" id="387005.A0A183HQ30"/>
    <dbReference type="WBParaSite" id="OFLC_0000959101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000959101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000959101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000959101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8625" checksum="8E8F37563A8DDE14" modified="2016-09-07" version="1">MHTKIIIDYIVVSSDAGRIVILEYNAQKVCFERIHWETFGKTGYRRIVAGQFLDVDPKGHAVLSGRYFEVPHFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQP5</accession>
    <name>A0A183HQP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9809</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012450">
        <property type="protein sequence ID" value="VDO63530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQP5"/>
    <dbReference type="STRING" id="387005.A0A183HQP5"/>
    <dbReference type="WBParaSite" id="OFLC_0000980601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000980601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000980601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF352">
        <property type="entry name" value="SYNAPTOTAGMIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="57"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO63530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000980601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23523" checksum="6E855BBE19ADF43C" modified="2016-09-07" version="1">MPSCLPSNLIVYDYDRLRKDSRIGQLSIPLKKIDFGITVEQWSRLNPPEQEANSESELGDLCFSLRYRLSTMILTVTIMEARNLKKMDVGGLSDPFVKMHLYNGQKLISKKKTTRKYNTLNPYYNESFQFKVEQKLLEKVHLVISVWDYDKMSKNDFIGEVKLGSPSLNNFTFSNDSQKQWFEMMTTTRPVVHWHTLQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQS8</accession>
    <name>A0A183HQS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9844</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012528">
        <property type="protein sequence ID" value="VDO63862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQS8"/>
    <dbReference type="STRING" id="387005.A0A183HQS8"/>
    <dbReference type="WBParaSite" id="OFLC_0000983901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000983901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000983901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO63862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000983901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13643" checksum="583AA74950DAE260" modified="2016-09-07" version="1">MSHNVYFRIPLKKQDSVHSHLLKAGSWEAYNDLVNFQIQRKRIQHKYEFGLRSDKNTVGETDEILKNYMDAQYYGQISIGTPPQNFSVVFDTGSSNLWVPSIKCPFLDIACCKLVQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRL0</accession>
    <name>A0A183HRL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DENN domain-containing protein 4C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013180">
        <property type="protein sequence ID" value="VDO66008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRL0"/>
    <dbReference type="STRING" id="387005.A0A183HRL0"/>
    <dbReference type="WBParaSite" id="OFLC_0001012101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001012101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001012101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001012101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10693" checksum="63CBF0C45CAD25B6" modified="2016-09-07" version="1">MCVYVCVFGRAGKHGKAITFLTPEDKDVFYDLKQCLLESPVSTCPPELANHPEAQHKPGTFVPKKRQEETLFHCIRYIDNITYRRSIFKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT26</accession>
    <name>A0A183HT26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014382">
        <property type="protein sequence ID" value="VDO70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT26"/>
    <dbReference type="STRING" id="387005.A0A183HT26"/>
    <dbReference type="WBParaSite" id="OFLC_0001063801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001063801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001063801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001063801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9133" checksum="949316629E2FEC36" modified="2016-09-07" version="1">MKKKKKPHRHAKAGHRSRQPDIKNNTSIQEESVKYDDTKIAGKNAVELNGVITAETDTCEDEDSSVRIDFYPFAYSLHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTB1</accession>
    <name>A0A183HTB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10723</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014618">
        <property type="protein sequence ID" value="VDO70811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTB1"/>
    <dbReference type="WBParaSite" id="OFLC_0001072301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001072301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001072301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001072301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8075" checksum="D528F152D0138F63" modified="2016-09-07" version="1">MIFLILKKHLKKIFKKVEKEAYEKCKRLGIEIDQLPLSLIDVIQIIDMYQQDPIIYDLEENSYFQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTK2</accession>
    <name>A0A183HTK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase like 21C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014855">
        <property type="protein sequence ID" value="VDO71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTK2"/>
    <dbReference type="STRING" id="387005.A0A183HTK2"/>
    <dbReference type="WBParaSite" id="OFLC_0001081401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001081401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001081401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001081401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16520" checksum="A83E8B2A5E2D3B0B" modified="2016-09-07" version="1">MLHFMRELKFGENEFKIRQECIGHVSCVVWDSAIVACHYFVRYQSFWKRKKVLELGAGTGVCSIVLAALGADVLATDLSEGIALLDRNIRENWKVITRNEGSVKAEILDWNDSYDKPLSFDVIIMIDVIYYLRIVVLLLPLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTP2</accession>
    <name>A0A183HTP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10856</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014960">
        <property type="protein sequence ID" value="VDO71883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTP2"/>
    <dbReference type="STRING" id="387005.A0A183HTP2"/>
    <dbReference type="WBParaSite" id="OFLC_0001085401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001085401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001085401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO71883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001085401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17954" checksum="E9C0BF1CCEC34CD5" modified="2016-09-07" version="1">MHSTLKCIIFRETSHPQCLFCEKRFLDEEFRYKHLRKEHFFCQICDADGRSNYFFSEHKDLLSHYKAKHIICEEGECLHLGIAFRTDTELKLHKSRDHAAGPQILNLDFHFSDRNTAGPSRGGRVTHSTRSTFSSKQNIPKIGVIPHEPSLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUJ7</accession>
    <name>A0A183HUJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4HBT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11160</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015760">
        <property type="protein sequence ID" value="VDO74314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUJ7"/>
    <dbReference type="STRING" id="387005.A0A183HUJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001115901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001115901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001115901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO74314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001115901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9658" checksum="D5DBCC4B833BBC6B" modified="2016-09-07" version="1">MVCQGIILGDKYGDKKLLLMEYYMLPVKLGEVIVIEAKVLKIGRNMAFAEAEFRRKSDGRLVAKGKHTIAFIPKPPAINGDSFEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUP9</accession>
    <name>A0A183HUP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LRRNT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11211</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015908">
        <property type="protein sequence ID" value="VDO74791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUP9"/>
    <dbReference type="STRING" id="387005.A0A183HUP9"/>
    <dbReference type="WBParaSite" id="OFLC_0001121101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001121101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001121101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552641" evidence="1">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001121101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13413" checksum="9B6561F6CFBF5350" modified="2016-09-07" version="1">MIKSTVALLYVVRFFLAFCAFGAVKAKRQTISEEDPNSRFQCQGSLSDYVACQCREQESELSCINAQFVDTNVFLHVNNHYRHLRKVTFHGNNFQDLPNRPLFGENEHTNLEVIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV06</accession>
    <name>A0A183HV06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11319</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016216">
        <property type="protein sequence ID" value="VDO75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV06"/>
    <dbReference type="STRING" id="387005.A0A183HV06"/>
    <dbReference type="WBParaSite" id="OFLC_0001131801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001131801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001131801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001131801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10228" checksum="3DB1CEA71771B6DC" modified="2016-09-07" version="1">MDDPRPVLYLWVAYCKGKQKSPHVMLFVINFPNDEGNLANEWTFIDLMIINYLTWYPENCTEWLSFRTIVSSPSREHTTRNSISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVH0</accession>
    <name>A0A183HVH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11478</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016613">
        <property type="protein sequence ID" value="VDO76786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVH0"/>
    <dbReference type="WBParaSite" id="OFLC_0001148201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001148201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001148201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO76786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001148201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18111" checksum="31683D51A4344E82" modified="2016-09-07" version="1">LELVRYSSVAAAAEVLLNLNKDHVFRQDLRDYGGSLSSVVTTTSSSPFSNTNNGVISNNTKLMVPSGTTGQVIGAAPISGIMMNAQVPTTSILANIDDSSSSRSNSPLARIPSPPTSASFQVRSTSPMLQIITNPYHQATDYHRMHVHLPVLALTLFYHLFLFFKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX34</accession>
    <name>A0A183HX34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AN1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12043</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018191">
        <property type="protein sequence ID" value="VDO81427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX34"/>
    <dbReference type="STRING" id="387005.A0A183HX34"/>
    <dbReference type="WBParaSite" id="OFLC_0001204601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001204601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001204601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO81427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001204601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16704" checksum="5F6F0CBCBFB4C090" modified="2016-09-07" version="1">MIIYSSGEHRFEHGCLAENLDARQLATSSNDGSKALKPYLCSMDGCFTSEIIRIDCEHCGFNFCLKHRYPEEHQCQIQDVANGQINSDLQEEIKEKMVMIVAGDRSNITEANIPSSSRSEKPVYSFFILFNVENDIFVNIFTTSHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY05</accession>
    <name>A0A183HY05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039831">
        <property type="protein sequence ID" value="VDP11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY05"/>
    <dbReference type="WBParaSite" id="OFLC_0001236801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001236801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001236801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001236801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7795" checksum="BB6A8FB7C9D60DAD" modified="2016-09-07" version="1">MLLSVFSSFTIPNALTEGTKGRYTTLQAVNRYVGEDRSQDEPHHCLAIRPSVGQTIFLPIPFQTKVLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY30</accession>
    <name>A0A183HY30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039834">
        <property type="protein sequence ID" value="VDP11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY30"/>
    <dbReference type="STRING" id="387005.A0A183HY30"/>
    <dbReference type="WBParaSite" id="OFLC_0001239301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001239301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001239301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001239301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26610" checksum="0B0E1A88CD466E18" modified="2016-09-07" version="1">MADNPIFQTTTNKQQFDVVPPPPLETAEKERQRLFEQGSSVHQFGDLPAVTEDAVRAALRNEAKRHKYWKASAVTKMTINRIDNTACLHYAMESFTEMRSTSKAVEAVTLGQFLQQQQSTSGTANIGLNPWDYAMDPPEDFVEQVKVLEMPGTSELMACHSCNAEGLTHCFYCRGYGTAVVRPPSGGLAYGVGTPVHFMTRAGVPPPGIGQHDLCHFCQGRGIRECSRCKGHGKKPCSACGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYA5</accession>
    <name>A0A183HYA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12467</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039849">
        <property type="protein sequence ID" value="VDP11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYA5"/>
    <dbReference type="STRING" id="387005.A0A183HYA5"/>
    <dbReference type="WBParaSite" id="OFLC_0001246801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001246801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001246801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE R03D7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001246801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40279" checksum="A4BC65E6146A510B" modified="2016-09-07" version="1">MREQTIQAIRVHGPGKGRNQEITFGEEHLHASGVFANVYSARLYRPVEMAIAIKKTWPGKGWSIINPEVYYLSRMKHRCIIKLLYHFTLTSNSDLCHCMVFDYLPTDMAKLRMNKIGRRFPLLDAKLYAFQMFSAIDYVNALGIAHRDVKPSNLIVDDEKGILKLADFGNAKLLTKNEENTPYQVTRYYRAPELIFGSTKYSTEVDIWACGCVLSEFVTGKVLLQGRNCQDQARLVIDIFGYPSTEQCQAMKVKKPRYARKRARGLRAILSNANAPADMIQLLEAILVYEPHLRLQGHEILGHSFFNDLRKIPAPVRSNGRAIPLLDYSVYQKSTQTTDSEETIDDIPDRNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZF3</accession>
    <name>A0A183HZF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12865</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039957">
        <property type="protein sequence ID" value="VDP12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZF3"/>
    <dbReference type="WBParaSite" id="OFLC_0001286601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001286601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001286601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001286601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="26339" checksum="5A55FF6FC8711B03" modified="2016-09-07" version="1">MFKLSHRLQSRLQNTWPRYKNIAFITLYIATLFPFQKFVKQSQMSNKNSNVEDYYGYWQLYPNNMRARRWFQQFEALKHGRPFCMRMLAALTVACHVAYYIYQFNAVNPEHRQDLKHVIWLKRKLPFCASMKQTKWFLKKYPNQYKAENMRTPILSFSCGVGFLSIVLVLYNRYCLDARKLPDGEAVDWRLMYYLKKHIPAFRNFGIPYREYKPDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZZ5</accession>
    <name>A0A183HZZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040027">
        <property type="protein sequence ID" value="VDP12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001305801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001305801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001305801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001305801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39500" checksum="D5B08C822D8DC735" modified="2016-09-07" version="1">MGLIYCLFTVKSTPSNDRSTVKIDELLNFGEHHLVIEHKELNRFADVFSQEYICPDNTMYLDLKPCNPNDRNQCPKNFACRRSRLSRSSTMTDEIIHLCCDAKNMTIGNWFEELELSPQIFPQFPSSTLEYVNISNYDTEHSSLIVHLGDELQVLNYLNYVTANIQAFKFQSITPASGGYLHIISVIDVTKRPLALFIQYDLPSTDSAAVNIENTTNSTNRFFGHMSNGTVPSQDTYRHQYIVIVYKTESPLSDQMNVTADVTRYIDHMPYFISDSATGRALGKPVAAIFFYITSKRTLFPIQPEFRPMPPYFPPHSKSSTIYNRNFILARFLFGIILMILMLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0C2</accession>
    <name>A0A183I0C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS13184</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040078">
        <property type="protein sequence ID" value="VDP13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0C2"/>
    <dbReference type="WBParaSite" id="OFLC_0001318501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001318501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001318501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="HYR_dom"/>
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    </dbReference>
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        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00181">
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        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SUSHI"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HYR" evidence="14">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="14">
        <location>
            <begin position="98"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="571"/>
            <end position="607"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0R2</accession>
    <name>A0A183I0R2_9BILA</name>
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            <fullName evidence="2">Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2 domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Onchocerca flexuosa</name>
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        <lineage>
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            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
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        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="41"/>
        </location>
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            <begin position="9"/>
            <end position="37"/>
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            <dbReference type="Pfam" id="PF25332"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="WBParaSite" id="OFLC_0001332501-mRNA-1"/>
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    <sequence length="42" mass="5096" checksum="64105F50C5807C99" modified="2016-09-07" version="1">MDNTTIRPVPMRLFANWETDRTIACAVQRLISFFLSFLFFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0S1</accession>
    <name>A0A183I0S1_9BILA</name>
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            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040149">
        <property type="protein sequence ID" value="VDP13472.1"/>
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        <property type="protein sequence ID" value="OFLC_0001333401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001333401"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001333401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="67189" checksum="BD2572A2489DEBC2" modified="2016-09-07" version="1">MGNLSPEEILKRIEGDNRGKAKGNQKNGTNGSKVKENTLLFFFQDHSSVVANGSKSSGGRKRGDKKDRQADKQAARRSLITDREVIELSAKMETLNVEKTKVIVVAETIAEPKHVSLRTGTSKVSSLGLTEILALSPQSDDIEEAKSGATTAAKSTVDEGVDDEEQYLSADEGANSNFSDDIKTELQYHTDEQSGASGSRDFISDGANYRADNEEINPLPVTSEESEFIQVTARSRRRAGVALFQQQQQSMAPGMDRKNVYFNSAIDRDSRTNIRRDADRLRRSSIQLPPDSRRNQPSSRGNTSPSSVDCESGGGKDQTIGINDSAQPQQQRQQQHLKFATSTSVSKKAKYGLPSSLQTSRAASPDRRGNQPLTLKYSIAAESLKSGSSPDVPFLSENLSDAKRKVSEHEIGTVTVGNIKTPAQRSWADIAKQRLYNDAETRPNDASHANMHGYSLDARTMVKEEHSLSAASSVSGHVQSAKKTEHSEQKRTVSVEAISSDLAVKDYSFFFDPNEPTGIVSKVICSTSESEPTNSKNVPKEANADSKSKWYLMEFMILQPRCSGIVLNLDGGRQLVLPESDVIAAGSSAIIDVNQRPEVITVNEIWRNFTEDPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I117</accession>
    <name>A0A183I117_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MORN repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13429</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040195">
        <property type="protein sequence ID" value="VDP13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I117"/>
    <dbReference type="STRING" id="387005.A0A183I117"/>
    <dbReference type="WBParaSite" id="OFLC_0001343001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001343001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001343001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000025">
        <property type="entry name" value="MORN repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000013">
        <property type="entry name" value="Putative Junctophilin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001343001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22117" checksum="785EB13958D27BCE" modified="2016-09-07" version="1">MNGGRFDFDDGGTYCGGWEEGKAHGHGVCTGPQGKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGVEQRGRWIYKGEWTQGYKGRYGHRLSMTSQAKYQGTWSAGFHDGYGTEIYVDGGTYQGQWLRGMRHGYGIRKSVQHSVAAKFRSRSRTNASLTSLRSEYGENEENERKNYGNFSALFMNFCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I150</accession>
    <name>A0A183I150_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040212">
        <property type="protein sequence ID" value="VDP13819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I150"/>
    <dbReference type="WBParaSite" id="OFLC_0001346301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001346301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001346301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001346301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12955" checksum="6B3C0EF4448C1F52" modified="2016-09-07" version="1">MHELIKKKKSHTVSFGVRSNDWHGELDPGLVKFKLKHVSPGTMLIPANVLGKAAQQVQREKGTTQREKVGTISRFSKLPPPPPPPPPVQAIFSRGKEEEIAFTVITPPLIPFWLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I179</accession>
    <name>A0A183I179_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13491</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040228">
        <property type="protein sequence ID" value="VDP13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I179"/>
    <dbReference type="STRING" id="387005.A0A183I179"/>
    <dbReference type="WBParaSite" id="OFLC_0001349201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001349201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001349201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Receptor L-domain" evidence="2">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Growth factor receptor" evidence="3">
        <location>
            <begin position="240"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001349201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="819" mass="93604" checksum="8AF96A0F29106807" modified="2016-09-07" version="1">MQYVKEKRIQQFFNNALRHDVVILQKTVEETLIQGEYCVIHCAEGYWHDPERNTRICEKCEHDICPKTCYLDEPIDSSNIGDLKNCTLLEGFVEILRHPFEPHRKFFSDGRPPIDIEKLTVEMLEALSKVKIVTEYVNVQAADYSPESLSFLRSLTTIEGRKLPDQVALLVTSNHNLKELGLRSLKKIKNGRVYVGNNPKLCYLDTMKDYWKEIMQRDVTTDLKIINNQLQDVCEFIGKICDKTCDQNYGCWGEGPSMCVKCADYEMDDKCSAFCPSEGYYVAGEKCQRCQSECKTCNGPTTLNCTECLNIRIQQGNNWECLAKCPMTHYSHKNTCLPCNPACYNFGCTGPSAVVGEGGCNKCKYARRFDHGQQLMCLHTTGKPKDVCRDNNLTHYYAAASSNEMLVVEFECNECSEECLSCSGYGTSVYRHKCSCAHYLTKTTSGNEYCTMKCEMDSFMIRPKSLDILGECERCHELCDLSMGCTGRTTANCTRCAKAGVLLENQLVCLEQCPINHPFIASNKICHTLDPEEQASKRFKLCCLSIIGITVKYVKYKKRYKEELEMNLPSIPEYEPMDPSMRPNMTRLCIITSENLEKTQQSLGQGAFGTVFLVYCWLRNPESRPSFVILKEKFNQYCKAPHLYVLDHHYKQQFESVLFGNQHELTDEVMYNNEFPDQFKFSGITTSTTSTSVPPSPTTPCWVTFQQGDINMRQERRLGSTDSGRYQSDPVCDGRTELSMDEGNYLVPNNKLILYTPVVVRENGETELMEGAEYYNDKLGTDYYNQLRSLSQETKEEARSIKVATYQNDYYFAETETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1L7</accession>
    <name>A0A183I1L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RSN1_7TM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13629</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040304">
        <property type="protein sequence ID" value="VDP14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1L7"/>
    <dbReference type="STRING" id="387005.A0A183I1L7"/>
    <dbReference type="WBParaSite" id="OFLC_0001363001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001363001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001363001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552723" evidence="2">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001363001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18924" checksum="C458FF59BB8A8C89" modified="2016-09-07" version="1">MLLVSIAVILIFTAPGVCYTRYINDLRATDEICPNENFLPMGVNRWSNGVHFQHRGQNVWGQLAIVIIAILFALPPLGLSCFQIATGASLFYMAILYNAQFATLISSKAFFVHLLTLLQRGFCLRASVDYAWPYPQKTFGNEQQHPRHRIYNLHYLTYLFSLINHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I303</accession>
    <name>A0A183I303_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14115</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040606">
        <property type="protein sequence ID" value="VDP15540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I303"/>
    <dbReference type="STRING" id="387005.A0A183I303"/>
    <dbReference type="WBParaSite" id="OFLC_0001412301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001412301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001412301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP15540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001412301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20836" checksum="A346798C90B03CC3" modified="2016-09-07" version="1">MGHIGSVQMSVPLAVEGMDALALAQEGERLCRENSMKAGIKYLEMALKKKINLGGRSLEALSAIYSQLGNAYFVLRIFDKALEYHRHDLETAKLLNDHSGLAKAHGNIANTYKALGDFNSAYEHAVAHLRLAQELNDKECEAAALYNVASVYHCRAKTIIHASEPLDKSGLLTASDMTATSQLQAAINCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I430</accession>
    <name>A0A183I430_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14492</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040900">
        <property type="protein sequence ID" value="VDP17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I430"/>
    <dbReference type="STRING" id="387005.A0A183I430"/>
    <dbReference type="WBParaSite" id="OFLC_0001450001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001450001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001450001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001450001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="45878" checksum="7ADC695C962E164E" modified="2016-09-07" version="1">MPTVQIQSAVGQHTGGTTTTLSTAIAASGTPLISTSVVDEGFTRRLIEAVKAQPCLYNPSHEHYGNKHSSAQYRIQVWQKLRSELGFKDDAHALQMQWKRIRDRYVRERRKRRNADSVVVNVIHQMVLTVPHQTNMACNHTTSLAAITSSSNMQHQQIQHLTSQAANNSQEAPGGRVQPRLAVILKYCFNGQNGSTLAVIAPTEVSNTGTYFVHYNVIGNAKQEAANQGTSISSADSVAVSSYQRTNQLPMISAQVSCDYNNLRDQRLSNGSNSDRNTNVISTSATDNGSPCSSTASSEIDVGTSAATTSHSSQQQIVLQQHQRQPVSQHPSSMVVLTAVQSQQMASPQQQQQPILLPKVEPRPKIGQQLQTADGGVVTVTARGVAPVTGVIKKDVNVRTNDGGTVTMIIDPTTFYQHGSQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4B6</accession>
    <name>A0A183I4B6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14578</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040970">
        <property type="protein sequence ID" value="VDP17699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4B6"/>
    <dbReference type="STRING" id="387005.A0A183I4B6"/>
    <dbReference type="WBParaSite" id="OFLC_0001458601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001458601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001458601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF17">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="5"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="57"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP17699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001458601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13598" checksum="DA8702A9558BF4D7" modified="2016-09-07" version="1">MQAMCEADSGCVPEGCDTDIHGRYGCGYFRLNIFHYKLCYQPGKEDDQDEEEAWLMCAKNYECSQECVRRLSNRYKLKCYGKSECETLARIHDGGANGCRSKDTLAYWNTVKEKCPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4J2</accession>
    <name>A0A183I4J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14654</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041045">
        <property type="protein sequence ID" value="VDP18041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4J2"/>
    <dbReference type="STRING" id="387005.A0A183I4J2"/>
    <dbReference type="WBParaSite" id="OFLC_0001466501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001466501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001466501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001466501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28128" checksum="8DC98B8E7FF64166" modified="2016-09-07" version="1">MIVIAFQESWESRLPSKHIKYGNNSASNCCNTKDFLRFNLTSDGSSKIAVEQSLIRAVANSDVMNSNDNRTSGDISRATQTVDKPSGIVINFNELNSVSSIENGCVNTNKIAYIDEDERTSDSYRSSNMPVGENLNDHMNGSAFKNVYTQGNSIQEIRALNDSEDDEVMLNIMSEVSKERESDSITEANIAGDRIQKSAEASPSTGIQGKHDDNPFTYSAGQLRLHGNRVGTYDMQKSRTLGVKRDVLTTDGEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Z7</accession>
    <name>A0A183I4Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMERB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14809</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041228">
        <property type="protein sequence ID" value="VDP18913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Z7"/>
    <dbReference type="STRING" id="387005.A0A183I4Z7"/>
    <dbReference type="WBParaSite" id="OFLC_0001482001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001482001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001482001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMERB" evidence="2">
        <location>
            <begin position="147"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP18913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001482001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33167" checksum="265DDEDF63577599" modified="2016-09-07" version="1">MDRTADFAHCSSLSSNDYFQKTDAIHSRPTIQTNFGLLAQMFSTERVKTPQFNNKVDRIISHFANPDGIAEDFNLHGANVKNQKDAGLLEEKILSRCASTPAFQALGSLAKKHSSFYQSTASSSHCAVGSIKTDLPDFQKLAEKILRQKEQERISAAQDMQRELEEIDVRKLEVEAVAGDLERRLRDDAENLWILEQWLLYVQEMTQLKQREEELKLRISELELNDKYKSLQLQLKEVQNIGDGVLFASNSQAEKSILKKTLAVLEMRDAIQKQLKVIRERYLIFHYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I595</accession>
    <name>A0A183I595_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14907</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041344">
        <property type="protein sequence ID" value="VDP19533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I595"/>
    <dbReference type="STRING" id="387005.A0A183I595"/>
    <dbReference type="WBParaSite" id="OFLC_0001491801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001491801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001491801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000291">
        <property type="entry name" value="Transmembrane matrix receptor MUP-4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="407"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="456"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP19533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001491801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55352" checksum="D5DC6F512516E77F" modified="2016-09-07" version="1">VDECALGTHECDENAKCEDTLDGYACQCKPGWFDNSPDRQHAPGRSCKKANLCANIQCAKEAECHETEFGPVCECFSGYVDFSRQHGMGAGHVCRKVINECATGKHDCSSSASCIDTANSFTCRCRDGFRDESPDLANRPGRVCVRALIPEPPECDVNDPMSCDAKKKEVCLFVNGTYKCQCAAGYDRLPDGRCLVINECDDQRLNDCASDADCIDQADGYTCQCKNGFADISPPDKPGRICRTRVNECAEPQKYHVDCDPNAVCIDTDEEYTCSCRPGFADISSSFERLPGRRCVEAINECLDPSLNDCSENAICEDAKEGYICTCRQGFVDASHNITHYPGRVCRKPRQEKLNDVSSSKGALIACDPNEPKCGSNEVCTDRKARGQFVCDCAKNAFRFTDNTCRFYAACVGINDCDKNAVCANAFDSYICQCRPGFIDISPDPEGKPGRICKELINECATGIHNCSSFATCIDATDGYMCVCNDGYVDTSSQFQLAPGRRCSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5H2</accession>
    <name>A0A183I5H2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14984</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041447">
        <property type="protein sequence ID" value="VDP19884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5H2"/>
    <dbReference type="STRING" id="387005.A0A183I5H2"/>
    <dbReference type="WBParaSite" id="OFLC_0001499501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001499501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001499501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="156"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="388"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP19884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001499501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="49647" checksum="018475B60B5AFA7C" modified="2016-09-07" version="1">MNAAIDVNQGINGQNSITIKNYKTSPRLTYKTVTGVNGPLVILGDVKFPQYAEIVQLTLPDGTKRSGQVLEITRNKAVVQVFEGTAGIDAKNTSCEFTGDILRTPVSEDMLGRILNGSGKPIDKGPPVLAEDFLDINGQPINPRCRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQIVRQGGLVKLPDKQYDAKDDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTVAEFLAYQCEKHVLVVLTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLASIYERAGRVEGRNGSITQIPILSMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTREDHSDVSNQLYACYAIGKDVQAMKAVVGEEALSSDDLLYLEFLTKFEKNFITQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5X1</accession>
    <name>A0A183I5X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15133</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041662">
        <property type="protein sequence ID" value="VDP20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5X1"/>
    <dbReference type="STRING" id="387005.A0A183I5X1"/>
    <dbReference type="WBParaSite" id="OFLC_0001514401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001514401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001514401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001514401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24401" checksum="026FDCD4821E73D7" modified="2016-09-07" version="1">MQGIRTACLMLSPDYRPPITYIVVQKRHHARMFCKYIRDAVGKAKNIPPGTVIDTGIVSPESFDFYLCSHFGIQGTSRPARYHVLWDDSKFTSDELQAITFNMCHTYGRCTRSVSIPAPVYYADLVATRARCHLKRKMGIYESDVTSDAASLISSSLSSLISAGCITNLRHIIDDDDDISDGESTKDDLVQSITSNSDATLQEYVTVSEKFKGRMYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6B1</accession>
    <name>A0A183I6B1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15272</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041863">
        <property type="protein sequence ID" value="VDP21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6B1"/>
    <dbReference type="STRING" id="387005.A0A183I6B1"/>
    <dbReference type="WBParaSite" id="OFLC_0001528401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001528401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001528401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001528401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24888" checksum="50119B94725BF200" modified="2016-09-07" version="1">MPETSVTEITVEKTPAYFVSKTAPGRVRSFNSTIKLIVVVRNPITRAISDYTQAISKKRRNALMPSFEEMVLGNSSSNATGMKNGVNASWGAIRIGIYHRHIRRWLQHFPLHQIHFVDGERLITNPAAEIYAVERFLTVKPVVQESNFATDPLKGFPCVLRKDESLHCLGKTKGRAHPHVRFDVIQKLEDFYRPQNEEFFKLINRRFHWNAYHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6S2</accession>
    <name>A0A183I6S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15433</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042134">
        <property type="protein sequence ID" value="VDP21871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6S2"/>
    <dbReference type="WBParaSite" id="OFLC_0001544501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001544501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001544501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF112">
        <property type="entry name" value="TRANSTHYRETIN-RELATED FAMILY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP21871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001544501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9147" checksum="D5101F7D9539B687" modified="2016-09-07" version="1">MKTRADGSYELQGGIGSIFGMDVVLKIYHDCDDGIKPCQRKVVLGIPSDYVTRSSNVKRWFDAGVLNMQFKFPDEERSCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6X6</accession>
    <name>A0A183I6X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042238">
        <property type="protein sequence ID" value="VDP22143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6X6"/>
    <dbReference type="WBParaSite" id="OFLC_0001549901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001549901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001549901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552794" evidence="1">
        <location>
            <begin position="24"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001549901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24099" checksum="EE05E848E6755372" modified="2016-09-07" version="1">MLQGFPLRKILCVLLVKFLNVRQNLILQHCPNLNNITIQTIRDENYLRQLSRIEHLNTLTLASSLLNSLSLSCLDALCTKKLRKLRILQRYDEMKTTRNVLRQSQLTLIISAPLITLQISGIALKPNIFTKLCDALKETLSELFISGALCNSPDFDQYISAIGKCDQITFISLDPQKLVIKPDRDSFINRIPGLFRFYKPNTGYISSEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8I7</accession>
    <name>A0A183I8I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16049</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043778">
        <property type="protein sequence ID" value="VDP26495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8I7"/>
    <dbReference type="WBParaSite" id="OFLC_0001606201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001606201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001606201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001999">
        <property type="entry name" value="Osteonectin_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00613">
        <property type="entry name" value="OSTEONECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001606201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5196" checksum="A2814601A4A0251B" modified="2016-09-07" version="1">MVQFPVRMADWLFQNLPNDILRLLEEKCKQLLTIALVLLKLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TUL7</accession>
    <name>A0A3P7TUL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000112">
        <property type="protein sequence ID" value="VDO25516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYP9"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF22">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="806" mass="89761" checksum="26D1850B4FD45B53" modified="2026-01-28" version="1">MDTAGLNFNFFATHPEHSVDLNYRGMRIKVYKNGDQYDTGTIVVICRKRFKHWLTFLDFLTKKLGLLAPVHEFYRTDGLHIRHFEEIENGGSYVAVSQGPFIHKQYGLLSEDREVRFIPRFIFEKWNINSKIEPPEQSALDSAESVDIYLKQRGYTSRTGLPFPFDGGVCVNHSLMDLGRNRDTSSNLSTRQYCNEQKSEENYSKNDELSKKSDAKPASARKEQQKSNSKLESELHLNSSPTTCNTGFPSSFSEVESKAPLHEFETINGQNIEQNYEILPMVEATNQTTNKTETNGLCYDIATQSDQKSTAKKSDESAPAAPIAQIPDNSREFSLAKDTKNMGSLGTMQTKNNDYSLPSRNAETVITIVNHDALVRRASNSSIIIVNISAGQKKGDDDANNVCSGGNRSAETGPAILDKVTGTEVPAQGLEVKVALPDSSRIMDQMKDATAATAGARTPRAILTNYVLQATTTDEYNGENSKINSKECSDDVLLRRNSKAQVEDFENFQNDILEQNLEAKLRDNLKQKTDLKKNQNDKLICDVSENNAESNDVSRNLKKPTLLSVQRSELENISDNFGCNKENDTTAKNQSSHIDVARGLKCRMPEDQSKNERPVISTISNSNKLQESLTTEKKSSPNRKQVTLATPSVVTSTFISNAVDMKMESGKAENFLDSEELLKPSSQQVTVDSNSANISATSTTLAVATAVITNTTSNNNMTDTTHATSGNVIMHTTAREKELPYLQKYRSESQMSFEADFTPRRGRMQKNSTSIKTVQKTKIDLDLNMDICGLPAQSNYDPDFKDYDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TVX9</accession>
    <name>A0A3P7TVX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000148">
        <property type="protein sequence ID" value="VDO25841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="74" mass="8137" checksum="EAD6E5D501C6ACBC" modified="2026-01-28" version="1">MVLQHKKCSSYPQNNSTYHLQLNGGNTTCWFSGSGAARQQGIIVFAPHKIFLNKAGRPPLLTSAAILFPQRPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VCX4</accession>
    <name>A0A3P7VCX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005732">
        <property type="protein sequence ID" value="VDO45680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HFB8"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="104" mass="11853" checksum="B46CBE6C8930D4DF" modified="2026-01-28" version="1">MELLQNALKISPDNAACRFYRARLLYEMHDYAQCLEELNDLKLIAHDEAQVFFLLGRVHKKLGGTHLALLNFSLAAEMDPRGEQSRNNFTDAPYDDEPSSPPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VF75</accession>
    <name>A0A3P7VF75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004156">
        <property type="protein sequence ID" value="VDO41919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VF75"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="353" mass="41345" checksum="406921296598AE2C" modified="2019-02-13" version="1">MITFRLGYRITICSTQCQDSAEKKKGVICNNDRKNEEKQVIHDDNHIDLNKKEQIFNDNNLNRVQHILPNLTDDGQWLFITWAEWSYKQWSEWSTLHRVEFNELDGTKRRNRCGIQETDPEIKTTTEKSQEKSERIKMFVQKLNRIREGFRDCDDDGDHTNEIKKSNVAQEEQKFREHSEELGYDFSKKELAIKSAEKQNFSELDAEENLKSESNSNKTNETEEKMDLFINPVTQLGEIENQTKDNFEKMKEETLSDDGNNLETQKSHATINCNISITKEVRTGYDDISGIAKTNENKEKDISTTKQRDDIDLMNPPQPHLNEKQALAEKKEQKDEAEEQMKSSASKQCFYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y1B7</accession>
    <name>A0A3P7Y1B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001016">
        <property type="protein sequence ID" value="VDO31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H360"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="594" mass="66171" checksum="9AA72A1437B40217" modified="2026-01-28" version="1">MASLQAHEDSDDNLYPIAILIDELRNEDVQLRLNSIRKLSTIALALGVERTRGELIQFLTDTIYDEDEVLLALAEQLGNFTPLVGGPDYVFCLLPPLENLATVEETVVRDKAVESLRKIADKHSSAALEEHFIPMIRRLATGDWFTSRTSACGLFSVAYPRVSPAIKAELRNLFRTLCRDDTPMVRRAAASKLGEFAKVFEADFLRDELLQMFMDLASDEQDSVRLLAVEACISIAALLTEEQRKELIKPVLINLIEDKSWRVRYMVAEKFTDIQSAVGKDITVNELLPAFSSLLKDMEGEVRSAAAAKIQAFCAALPATGREKAILTHVLPVVKELVTDPNQHVKTALASVVMGLAPILGKDLTMEHLLPIYLTLLRDETAEVRLNIISSLDKVNEVIGASQLSQSLLPSIVELAEDGKWRVRLAIVDFMPLLAAQLGQEFFDEKLLPLCMAWLTDHVYAIREAATGILKQLTEKFGTEWAMKQVVPKVTALASDTNYLHRMACLFCFNTLCEALGAEHTVKEILPVVQQLSDDHVPNVRFNVAKTLLRIGHTIDEGVVNNQIKPLLAKMCNDSEFDVRYFADETRMALGLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YRK4</accession>
    <name>A0A3P7YRK4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA splicing factor component Cdc5p/Cef1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004301">
        <property type="protein sequence ID" value="VDO42262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YRK4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA splicing factor component Cdc5p/Cef1 C-terminal" evidence="4">
        <location>
            <begin position="185"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="330" mass="37015" checksum="3ECE2A9BAD5C3713" modified="2019-02-13" version="1">MFQIPFEKPVPPGFYDPSEDKFEKDTTFKKQTRAEIEGVRRDDIENEERKKDREKLKKRRSEGNPESIFEQKIEKKRSKLILPSPQISDKEMEEIVKIGQATDTIREFSDNNPTSTLLHDYQMPMHENTGRTARTPSMYADVLQKEAENLLALQNAPTPLKGGINTPLHDLNLQSALPQDRSIATPNTVLSNIAATPSSVLQGTPGQSEPPTPSGTPFRDQLSINNPQLSYDSRGELKKALSSLPAPRNEFVIMAPPEETEASQEETADWVEDASEVDVQKKEANELLRIQKLKKESQVIQRGLPKPSKINEQSFKAVSSKSDIGKVNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YUK5</accession>
    <name>A0A3P7YUK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016290">
        <property type="protein sequence ID" value="VDO75794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YUK5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="106" mass="12495" checksum="F7535C07133BB137" modified="2019-02-13" version="1">MICAELSFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGNVFQKNTRRAAEVWLDDYKHLYLRKVPSARYVNFGDITARLDLKKRLHCKNFDWYLKEIYPELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZQK2</accession>
    <name>A0A3P7ZQK2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS7600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008046">
        <property type="protein sequence ID" value="VDO51795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZQK2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO51795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="100" mass="11361" checksum="B49AD819BBBF6D72" modified="2019-02-13" version="1">MQLFYSFFKSLVGKDVVVELKNDLSICGTLHSVDQYLNMKLTDISVTDSERYPHMLSVKNCFIRGSVVRYVQLPADQVDTQLLQDASRKEVMQAKRSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BXU8</accession>
    <name>A0A3P8BXU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016598">
        <property type="protein sequence ID" value="VDO76752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BXU8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018193969" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="110" mass="12422" checksum="44D3F173F4707853" modified="2019-02-13" version="1" fragment="single">MNCIKFWIFAIFCSSFPVTYTVGQGTIIIIPEELIFSDAFPGRISSHSLKVFSTFKEEMHVLRISSLFGDRKVFLEMANPKNTPIIKTKALSDLGRVHVIPSVNCTDDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F473</accession>
    <name>A0A3P8F473_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="UZAJ01041222">
        <property type="protein sequence ID" value="VDP18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8F473"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="75"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="458" mass="52340" checksum="81D6976A3C850DAB" modified="2019-02-13" version="1" fragment="single">MQYLSSEAKGCDLLVLWLDCDKEGENICFEVIEAVKNSMKKPRTGDIMRNIYRAHFSAITAKDIKSAMRNLIRPNINESLSVDARQELDLRIGCAFTRFQTRYFQGKYGDLDSTTISFGPCQTPTLGFCVTRHDLITQFKPEPYWVLETVFETPAGEKLKPTHVRGRIFDKDVCQLFLDRIKGFISYPRTETTAYPSNFDFLEALRHQQNDNRWNDIVKKLLVEGITKPRNGEDKGDHPPITPLRCNDGSLSGDALKVYEYVTQHFIATLMKPCVYLVTTIKIDVANEIFVAKSKSIINLGYTEIMVWQKIDEVALNYDIVKGTKLSLKNGVMCEYVTTPPDYLTESELISLMEKHGIGTDASIPVHINNICQRNYVTVESRRRLIPTKLGIALVHGYWKIDSELVLPTMRSEVENQLNLIAKGYADFSSVKNHVLENFRLKFIYFVENIGLVDSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZJ0</accession>
    <name>A0A183GZJ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000235">
        <property type="protein sequence ID" value="VDO26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZJ0"/>
    <dbReference type="STRING" id="387005.A0A183GZJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000064901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000064901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000064901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000030">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000064901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13494" checksum="AE9AD46DD3A25E35" modified="2016-09-07" version="1">MSWADLVNNNLVGSGNVSKAAICGFDGSIWGKSDNFKLEPAEAAAAGKGFQNKDSLLGTGMKFEGEKYFVLQADDERIIGKKGSTGFFIYKTGQAVIISIYEGGVQPEQCSKTTGALADYFKSINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZY8</accession>
    <name>A0A183GZY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS798</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000312">
        <property type="protein sequence ID" value="VDO27112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000079701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000079701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000079701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000079701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8145" checksum="202C3F0877D75483" modified="2016-09-07" version="1">MDICFIDFLQSNLENCNGAGSAATLRYCTSQMSSSSSFTSRHLLLHPHFFHISSSATTMMDRREPISKLLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H144</accession>
    <name>A0A183H144_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1204</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000532">
        <property type="protein sequence ID" value="VDO28649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H144"/>
    <dbReference type="STRING" id="387005.A0A183H144"/>
    <dbReference type="WBParaSite" id="OFLC_0000120301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000120301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000120301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000120301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="60159" checksum="E1C22EC1F00DF0B6" modified="2016-09-07" version="1">MSVCSEGTTYEASEKFKLWHSSHLLLNCLVVMWLPLRLILDDKKYAKENENLRRLLTKLFKFAFLHYRNTSILEAVMHLGKTLDDWKEGKILVLQELLQNCSLDDEKATVYLEAAINWDFLALLKFIDDAFGIVKREIHGDSPPRKRDKKSKIPNDAFNRSLLYLDRIMKQPEIKHQLEHNYIVYVSRYCKALTSLRQLIMENIFQKKLQFSSFTLTFGNIISGIRMQYILAVMVLTGNAKVFFLFLSYTKDDGEELLKIMQDDVDWLKESIIPQFLADLNDEQLDMVIKVCETYISLWTQQLRTYNTPLAFRLALCDVQWIENIKKSHGAVQLLVAVIELFRNLIITAAVDNELIDVIMTSLSISIFKYVATCSKSKSADFDHKTRIIQRPFDPSLEINEVIDFWINKILVKHRLLRCSVLVYLKDLIENHIAITTQEDEIYRNIFSYGAVIQLLLLLRSSAKKISSKLVSNSMRKSRDLYDACVGILGEQLRGLNYKYEKNEMFLHMNDVFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1C7</accession>
    <name>A0A183H1C7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000582">
        <property type="protein sequence ID" value="VDO28980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1C7"/>
    <dbReference type="WBParaSite" id="OFLC_0000128601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000128601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000128601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000128601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13118" checksum="E474A3C43BC0CD88" modified="2016-09-07" version="1">MYSRYGVNGKFFSKRTINIDCGSCYANLVWFIPDHYPDGFHDDESASKKPLTPQSKQYYEGSAQLIPHENNTKAVLLSHLDEFGSDERLESNADIPVYIIDSDAIVKPLDLLFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2M2</accession>
    <name>A0A183H2M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000870">
        <property type="protein sequence ID" value="VDO30594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2M2"/>
    <dbReference type="WBParaSite" id="OFLC_0000173101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000173101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000173101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000173101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11381" checksum="982A50FF7BD5DD4B" modified="2016-09-07" version="1">MSRNNALIILNKQINGQIWMDGRGHRVHPNTYNFHSKQYRHRRDVAGSTARGLKYLTIRIYAKLICINRVHTVPLKSENHFLSLFTQLNDVLELQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2V3</accession>
    <name>A0A183H2V3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1813</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000927">
        <property type="protein sequence ID" value="VDO30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2V3"/>
    <dbReference type="STRING" id="387005.A0A183H2V3"/>
    <dbReference type="WBParaSite" id="OFLC_0000181201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000181201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000181201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="71"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000181201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44541" checksum="A34514D56B812E0E" modified="2016-09-07" version="1">PNYFLDDYIIWCRPSPLQCFIYKRLKKFLSYDHLTLIDVLRKLCNHPSILYQSIVTKLQTCKRLLSGKLSVFGELMGTFREQEEKVVVVSNFTKTLDLLEELCQTLYYTVLRLDGSTEAKKRMEIVEEFNLVSNKNCAFLLSAKAGGLGLNLIGASRMILFDSDWNPAVDMQAMARIWRQGQKRPCYIYRLITGGTVDEKILQRQIKKSSLSVIVEMVPVESLTHFSDEELQDIFTLRDETECETHCLLECQCNGCGLLPEELEADREINPNSNAPSKLNVENVTSVKMDENEDRTSIPEDSVQSSSADPLIQNCSGSTCPNNNEVLEDEAENKILGDEAALSASALMGTLMRWQHYSPKYEKQFELMKAQAGLEKCCLEEVSFIMKLVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3C3</accession>
    <name>A0A183H3C3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1983</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="UZAJ01001057">
        <property type="protein sequence ID" value="VDO31477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3C3"/>
    <dbReference type="STRING" id="387005.A0A183H3C3"/>
    <dbReference type="WBParaSite" id="OFLC_0000198201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000198201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000198201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO31477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000198201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32267" checksum="0E0F544C0150C31E" modified="2016-09-07" version="1">MLIKLQNIASELCLVDVVADKLKGEMMDLQHGIPFMSPCIIRASVDYEITKGSKLCVVTAGVRQREGESRLSLVQRNVEIFKGIIPKLIQNSPDTLLLIVSNPVDVLTYVAWKISGLPPHRVFGSGTNLDSARFRFLLSEKLGIAPTSCHGWIIGEHGDSSVPVWSGVNVAGVALRDVKPDIGKSADSDKWQEEIHKGVVSAAYEIIKLKGYTSWAIGMSTGAIASTALRNTRSVCALSINVKGLHGIDQDVYLSLPVVLGENGITHIVKQNLNETEVKQLQASAAQLYEVQCGIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3G0</accession>
    <name>A0A183H3G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LsmAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2020</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001085">
        <property type="protein sequence ID" value="VDO31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3G0"/>
    <dbReference type="STRING" id="387005.A0A183H3G0"/>
    <dbReference type="WBParaSite" id="OFLC_0000201901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000201901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000201901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000201901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="110913" checksum="8042B49B27B6D486" modified="2016-09-07" version="1">MYMKYEGKEVLLETRDGLTFEGIFAGCSPDVSISLHRFIFWGFDVGLRYAHEVLTDDQKNLLPHKDQIIEKLQFERDCVYSMGAKYRDEKRIEGRRFATDREYADQSGSTADMELQVWESEEDFDDGLLLNDDQENGWSAEQMFQANDVLGVKSTFDENMPEYATADVQGDADDLKRAERIAQEINSNSASKARAQLENDDEERDLDKETPEFQVQHSSRKGSSTGLSALCPVKSSSIKNGSNIYNPFRRGSYSGNIRDRAGLNMNRGPPNGRRLEGMPGIGRGRGSYGSSGSSRLFTNSSMGHGLRPQNSVGSGPTSRYAPSGILERPTAQELHLQFGQWVRRGESSGSSSTTDSIRGGRRSEQMVGNNARVYDHRLMGSQHEGQPSRTLFIFPFNLFINILRAVIQERLIFAGEENKNLHYSITSNSVSGASRQQASKQIERVKNLKEFHQNFNSTFQPSHSVHSNEDDVQRANSVHASTSSVAPRPVNNAWNKGPPPGMRAPSSSTQIASNHRPEISSTRDLEISASVASTTATSCPPCSDQQSQQAMVKTRGSVQAVVTSGRAITAPAEVALTAISDSRSNKPTSSIVPVPDTTSSNIDTTGIVVLDTQTATMPIAAREIQQTHQLSAAASSSSIAPIDPTPTAAVIDSAKTTAANSATTTSDGKHFVWNPDAPSFVPRNLTNYRSSESQNHRPTLHSVRTPPAAPLPLMSTHIAAPGQIQGLALANPQALSVQNVPSIAHAGPPQMFPYAHANAYGTAMPVYYNTPVVQSAPSAAAATATAAANVTGGPIVASTAGLSIARHGQMAGQTPSTNRRNQQQQFMQGVAGMYVPGASQPYAQQLMSQYQMPYFAPYPSQLSIGASSNMPPPPIPPPSTNAVLTAPPPYQIIQAQTQQQTGFPRQLYQGDHSVNYMISRLPQSHPNVDYTATTVSTQQHPQQGSSGASSNGTGSNGPNSQPATPGPVVSSPQVRKYHYIMTEHIIRSKYLSCLNDSELFEMANKLIDLLRLTFKKWNNVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3R8</accession>
    <name>A0A183H3R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2128</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001164">
        <property type="protein sequence ID" value="VDO31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3R8"/>
    <dbReference type="WBParaSite" id="OFLC_0000212701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000212701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000212701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000212701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9678" checksum="DA5DA85D3F99398A" modified="2016-09-07" version="1">MSRHATPRQHRPPIYTMTSNQPTTTQTTQRTDESLHPMDIITARPRRSAMPRVTQFGRKLWFPLEIHGRSGKNIPAAPGIAHIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H441</accession>
    <name>A0A183H441_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PKS_KS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2251</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001253">
        <property type="protein sequence ID" value="VDO32373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H441"/>
    <dbReference type="STRING" id="387005.A0A183H441"/>
    <dbReference type="WBParaSite" id="OFLC_0000225001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000225001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000225001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO32373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000225001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16196" checksum="24298192AAD4D3E1" modified="2016-09-07" version="1">MIQDNKAARAKCLNPTELRGSRTGVFVGCSASETGGALTQDPETVTGYTLTGCVRSMFSNRLSFTFDLRGPSFSVDTACSSSLCALQLAVDAIRLEQCDAAIVAGAHLTLTPTAALQFLRLGMLSDKGSCRSFDASGNHLVLLQLYKILSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4U6</accession>
    <name>A0A183H4U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spindle and centriole-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2506</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001453">
        <property type="protein sequence ID" value="VDO33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4U6"/>
    <dbReference type="STRING" id="387005.A0A183H4U6"/>
    <dbReference type="WBParaSite" id="OFLC_0000250501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000250501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000250501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000250501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47410" checksum="EB103AB043438D40" modified="2016-09-07" version="1">MNSEKIIHGLGTSRAHRKFSVVSNSQRKKFSKMATTDQNARPLDEFEKLKEEVHEMQLKIDEFTKLKEDVHDMQLKDLERSGQLLQLTKTMKKILGGLAQYNILSNDNNEDSKIHEKKIGAGVRYCDKENKKYVSEYLTEGDERSLIVHGELFADATEKIGSSKEDLKWAIMKRKYAENEEFKRLVDEAIMKCGGDESLDIFASDQNKGDTGRFRVRSLWKKKPQPNSPIIRSTTRVTKQMTVEQIGRCGNSPVSCAFSYDSEKYLARHGIIPELSDDDEVKYKMVCGKQSDPSVQSYYYPGNSATYYSKNTKGNNMPLKDNSCLDLSRNRTSHSNYREKRRYYKEEKLPRSVFDKINYQIDQFDTDDDEDVNSMIVINDVLEVEDHCETGVKIRSPEETKGWRDVFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Y3</accession>
    <name>A0A183H5Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2894</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001788">
        <property type="protein sequence ID" value="VDO34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Y3"/>
    <dbReference type="STRING" id="387005.A0A183H5Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000289301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000289301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000289301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="145"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000289301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54774" checksum="BDDC3B5C260D78A6" modified="2016-09-07" version="1">MSEIKQKHHKTAEDFKERQLDAEALHDYAKTVFKFKKIQVVFIQLHSHIGSINGLQHVIFIGNGSLLKLEDLEKMHPPLNFQLVAPLHLLAKIAKINCNDKFFFYGDKLNFAALPSNVKLITVPALEANLKPQHRGFFLNPQGKTSVSVLHEYVQKVLKSTINYHFSETRNSSMPYGCTARLKMNLNNRVLCATSVKEKLMLLQEKQRREQRLQEHGEQPDADFVVLGTGCGNSKKTAKLDAARNALKVLIPDVEFDPEGIAISDKKVKDEAESDKEDAVALFDMLPIEDSRIFDLSARAGQPSPYLLLQECLKRNAAYGDTEIKVHSVRVKHQRHQFDMDVGKHRVSVICANKREGKQKASQAMLKKLHPNLDTWGSLIRLYGHGTQQKQQEARKSRQSIIKLQGNRTKESSALEPNNAILEKLRMEMLKLSKAKQSIETSNVLVSKRPKLSATNEPVNEIESAQASASYAATHPDALSVLRIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H681</accession>
    <name>A0A183H681_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fmp27_GFWDK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2995</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001873">
        <property type="protein sequence ID" value="VDO34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H681"/>
    <dbReference type="STRING" id="387005.A0A183H681"/>
    <dbReference type="WBParaSite" id="OFLC_0000299101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000299101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000299101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000299101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70909" checksum="5B581D7DE9ACC8E9" modified="2016-09-07" version="1">DDDHDCWIDWISVICTGTSVFEGIRIPNNKAVIREVPVPDIVITTSLANLNIKLTTDFYRLLRGFLSMNLGEPLVPSSETIPIEILQRPAELYEVIGASSKYASFSFRMILTNVEFNCFMQCENPSQGFVSFAGVKLNSSRILFDVYIDNQSELDLICESTELIDTRFIDVEFDKRPNVFYSVLFPLSKEDSKRNKLMSEAHIIFKCDEAPVITLVLLNARVLLLLDWLNDVKNFILLHSDFIPPVEDVYRGIAHTMKSGIIERDRQIRESVVQTFSLKITLKECDLILLEKPDSLHSLALVAHTTAVLNMNDAHELLNVNLEIQRVNVDWFMMASESESRCQLTNDFAITLSLSVESDADVEGQLPRLGLSSAEITDMVARVSYRDLQMVRNVLTSSLKRLNKSYKKSVIPKCNPQFGKNEGALINVVRAIIKGSQISFWLMDDHQGRVFPLIRCKFRKFYLNRYLEKIDGYFTFVADYFNQNIFGWEPLIEDWDLKQLTVVTKNNTIFMDLFADEHSTFNINITQAFLRQAMRFNLQLFEIKHALDEDFRGPCVRSRSDHLPYILHNETGSSLRFTTAVDEVVEARSVQRKSTAKWYQTAPNASTTFEFPTKRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H683</accession>
    <name>A0A183H683_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tricarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2993</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001872">
        <property type="protein sequence ID" value="VDO34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H683"/>
    <dbReference type="STRING" id="387005.A0A183H683"/>
    <dbReference type="WBParaSite" id="OFLC_0000299301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000299301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000299301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000299301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24663" checksum="251876CD85A4B1A8" modified="2016-09-07" version="1">MMCSSRLLHNTYRNYIPGLPLSKSMVHFRFSAFANRLLPVAESAVPEVGLSPAINKPSKIVRECDVANVNWSVGLGEQGCQQVGSLHTSTKASAIPEKIISVGAVGGEISGKKPPPVLEWNPMVHTEWQLGVGARLLPKLPEGTKVGKLVMGKYGLYRPGLHEITQQFFINTELKGMAPENALPLSALLAKIGKILMVVPIITVLLNLPTLLAQKPVGIYAGYIPPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6W7</accession>
    <name>A0A183H6W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3229</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002094">
        <property type="protein sequence ID" value="VDO35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6W7"/>
    <dbReference type="STRING" id="387005.A0A183H6W7"/>
    <dbReference type="WBParaSite" id="OFLC_0000322801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000322801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000322801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000322801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16110" checksum="68B1AD6FB1BB24A2" modified="2016-09-07" version="1">NSTVEDTVYSGGCLQHYHWCAYTPRVPFFLYSFAATVLFGLAFPFLASPVGTLYSQILGPRNQGLMQGIFEFFGSSARFLGPIISTTLFEKSGYLWPMLIQLTLLIGCIILNIIFRHRLIPLRLKPEIGVPTKYKFGTFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Y4</accession>
    <name>A0A183H6Y4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3243</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002108">
        <property type="protein sequence ID" value="VDO35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Y4"/>
    <dbReference type="WBParaSite" id="OFLC_0000324501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000324501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000324501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000324501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20338" checksum="D0D5C4946202F395" modified="2016-09-07" version="1">MIFELTTPNPYDEQLDISKLISRQLQPVLVPVFHQYDADYLLEALNDLSNQSTSTHFPPVTIIDETSENAKNKLQRTSYNMLKRPNIHSTKNMLRHYPAKAAFPSAVCNSRRLRKIMLQAITTNVSESKRSITAAAEYVYHGMKFDVVCAQGDFSYVIHARKYCEVIKENITCFAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7E1</accession>
    <name>A0A183H7E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3403</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002262">
        <property type="protein sequence ID" value="VDO36380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7E1"/>
    <dbReference type="STRING" id="387005.A0A183H7E1"/>
    <dbReference type="WBParaSite" id="OFLC_0000340201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000340201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000340201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000340201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59540" checksum="6E08159ED44B3901" modified="2016-09-07" version="1">MVGVVIQTPVVEGDNILTQEGLLEHVTILEQIAKYEVNVAGENWTLADLCFKPPSPKIENSFVTQFLPIIDKIIPCIWITPIDCFWEGSKAIGPHPSIESSSLGFGKEFLSSLSNMDTLSWSNIDPQTLLDELAEILDLDNFNSFFRRANIGRGYLDRWCIDPLNPECPTESPNHFAFCDLIPRFLEYARKQGFEVSVDPEYLRREEEKRNQIDEYSFFGFFGKRRKRGSEYIEKLTDNYLSVSGMSNGTNRPELSFSKDETIKTNETISNSKHAANSTNSKQVATSVVPAEAKSIGTDQLAEIVPNPKIISSSVVKEKKKGSIAQQDDNDFIYYDDEDKEFNLNAELCAKYARPFSEWLRNNTDKWHEFLKLHEMPVLPNYGEIMTGGCRSFAKDIMSWPQDLIIGGVQIKNGTIESAEALQSVFLVASAVDIYNRFKDGGKVHSKPNLNLMQWNVTVAENVVRTWQRDFTKNLYNHEWNFIIDQKSDSKIAHRRIHPLASTSVADMLKEFCKFNYSIIFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7S3</accession>
    <name>A0A183H7S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3535</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002385">
        <property type="protein sequence ID" value="VDO36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7S3"/>
    <dbReference type="STRING" id="387005.A0A183H7S3"/>
    <dbReference type="WBParaSite" id="OFLC_0000353401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000353401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000353401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084">
        <property type="entry name" value="GEX INTERACTING PROTEIN PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000353401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31559" checksum="61E61FC994B1C1ED" modified="2016-09-07" version="1">MSGHGRSRGRPPMYAAAAAAIQQQQGNVMLPPGQANFVEFHLIVTITATPMINETEIKPPYRVTAPRHMNATPSRRDILAVATAASVGPTTGISPEQKLEMQRAKRAERARLRYHNMSAEERRNFNARRAKALRTARMRDDELCRMAERAQMSGTTLDADLMIQVAEAQRRRAKRAEAARLKYHRMSSEERRQYNAMRDAQRRQRLEEQELMERERQQQEQQQQQQQQQQNEIHQETREQDTNREGNNEQILYDSYIRYDSQMDHGWAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H886</accession>
    <name>A0A183H886_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1794 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3698</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002567">
        <property type="protein sequence ID" value="VDO37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H886"/>
    <dbReference type="WBParaSite" id="OFLC_0000369701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000369701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000369701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF16">
        <property type="entry name" value="THAP4-LIKE HEME-BINDING BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000369701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11145" checksum="6A447AEE90AEDEA4" modified="2016-09-07" version="1">MTAGNNGLTLFLKLFISNRFTTYEVGEVAPNKMILTLKDIGRISFSRDLPVEDLRRTFIKHDDQYLEQIIEMRTATHPKQGYLEHTRVIYTKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8A0</accession>
    <name>A0A183H8A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aamy domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3712</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002582">
        <property type="protein sequence ID" value="VDO37522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8A0"/>
    <dbReference type="STRING" id="387005.A0A183H8A0"/>
    <dbReference type="WBParaSite" id="OFLC_0000371101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000371101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000371101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF230">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000371101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35751" checksum="ED61C5F3A793F1D1" modified="2016-09-07" version="1">DWSRIGDILRDIRNHVDTHVEKNSSNNNTKHIVLFAARDNANEDEKKELILSGLDSVISYELGSIGKDNKICHLTEGNVAGCIHEILTELVQFHAANNISAFWEFGNPQLSRIASRVKSQQQAELLTMLQLFLPGTNSIYYGDEIGMVDLPIKKLVPVQRGAMQWDDSVNAGFSSAESSAIPVHPNFTNNNWARQYGSERSHLKTFQRIARLRKIDETLIAGGIIIGQLINSSFTVIRYPNNGNTSTGDIYLGAFNFGKGDTTLPIRESNIMENKELHQAMIIASSSNTEQYYYRQVIDLKNDTVTVSPEQGVIFKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H955</accession>
    <name>A0A183H955_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4019</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002894">
        <property type="protein sequence ID" value="VDO38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H955"/>
    <dbReference type="STRING" id="387005.A0A183H955"/>
    <dbReference type="WBParaSite" id="OFLC_0000401601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000401601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000401601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000401601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10198" checksum="A5714C4D09AFAEAF" modified="2016-09-07" version="1">MSLIIHNIYDEAVAQALAMAIPVKQHPAQASQLHAISTVVKLIGYRKKRNNSYGDEAIFPTEDLAISQPTPVEHAPEHAAQSYADEASITPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9R6</accession>
    <name>A0A183H9R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IlGF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4228</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003124">
        <property type="protein sequence ID" value="VDO39340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9R6"/>
    <dbReference type="WBParaSite" id="OFLC_0000422701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000422701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000422701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000422701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10841" checksum="6EC4E84A5439DBA7" modified="2016-09-07" version="1">MHLSRLINTSLVILKTEIIAAQNFGSLVLCPPGGQSFATAYMMACEMKKRRRKKRDIGNPMRPATLKEVQNICCEVGCELRDLLNYCDPFDWFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9R9</accession>
    <name>A0A183H9R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gnk2-homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003128">
        <property type="protein sequence ID" value="VDO39344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9R9"/>
    <dbReference type="STRING" id="387005.A0A183H9R9"/>
    <dbReference type="WBParaSite" id="OFLC_0000423001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000423001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000423001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000423001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12355" checksum="3025067BADD0E175" modified="2016-09-07" version="1">MKKIFGRKKLKKSKSNQHEKLDENFSINGTTIFATSGTFCRTTYGFKESTALNECHSCFDAASSSIGECHFDEELDKHMMRTIADVKYVKKRPKFVAVGKFHIRRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAA5</accession>
    <name>A0A183HAA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4415</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003341">
        <property type="protein sequence ID" value="VDO39935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAA5"/>
    <dbReference type="STRING" id="387005.A0A183HAA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000441601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000441601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000441601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF27">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000441601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34106" checksum="7C1A6817446A94D1" modified="2016-09-07" version="1">MIISPELKGIEQSLTVIVSFHDIFITKIDRAFRCTCFYIEADRVVTSRFDVSMIPTTDLIDTARMPHCTYTVRRDSVVGKVVSFAIVGEPVFHVWKCDSDMFSILVHSCFVEDGKGYEKKFLIDERGCAIEPTIMPDLTYNEDRNMAFSKVNVFKFADKLTIYFQCALSTCMRSEERCNEKIPPICINDQMEYFGEEIAQKFGKEEIVEKIAGTMSKYRKIRNAVMPISSILLKNQTLSNGHNYMMDLFADKIVVLDLEEEKSSGIAKISSQVKLFAIKLSSIRFIVIEYNRHNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAB7</accession>
    <name>A0A183HAB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">28S ribosomal protein S17, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003357">
        <property type="protein sequence ID" value="VDO39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAB7"/>
    <dbReference type="STRING" id="387005.A0A183HAB7"/>
    <dbReference type="WBParaSite" id="OFLC_0000442801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000442801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000442801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039193">
        <property type="entry name" value="Ribosomal_uS17m_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000442801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24728" checksum="F30F5EE1A6C2B095" modified="2016-09-07" version="1">MNFTAQLLKIEPVLCIANRCKTELSKNTLDMLLGKVLKHTHIGNDKIPCVQVRCRLNDFDEYIKKYFSRPIDLWALDPKNTAGRLGDTILITKCDVNKRPAKLVTHIVDRVMFKYGNIIDPITKKRVIKEKYEDDINLQTELVKEIIEEPSSYDVLLFEEKRDIQWRRLNTRKMAISQRELSKHGRLSTRRMIKNISKEKEEELNKDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAG7</accession>
    <name>A0A183HAG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BCAS3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4479</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003414">
        <property type="protein sequence ID" value="VDO40114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAG7"/>
    <dbReference type="WBParaSite" id="OFLC_0000447801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000447801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000447801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000447801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19970" checksum="E0EFE511DEE67D78" modified="2016-09-07" version="1">MTVRYIPKKVPAIDAAVSTDPVFMTNQSIGKIEVGVNTIIEMGTYMTDGSSSSNTASDNSVGQLPKRLFDTILQKPSLRIVSLRPDGSVVPKDDSVSRHFPSVREWTGNVGEVTSEENTEKSVLDSKAEACDITSKSDLSHSGHNEKEGLVGSVTSGRHSVSASASQPDPFEDDLNTLANISPLPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAS8</accession>
    <name>A0A183HAS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003554">
        <property type="protein sequence ID" value="VDO40427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAS8"/>
    <dbReference type="STRING" id="387005.A0A183HAS8"/>
    <dbReference type="WBParaSite" id="OFLC_0000458901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000458901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000458901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000458901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22799" checksum="E70F48DBB8C4FF62" modified="2016-09-07" version="1">MLDENKRKRNILLEDKKNDDFLAPKRSKKVNNQSDRILGENIVKVVRQEPVQENEHMHELESTLSIESSSAFLLPVRPRLPSNPFKRKSQTIFDSNEDNFFDSLASASTTSRKKNDDISDWKKLKTELSKTRQTTLSMKLAEEKESNEMKTGFELWLKSAESKLRKDYDGDDDFLEYAIKQFRHLKTEEKQVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB01</accession>
    <name>A0A183HB01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein arginine N-methyltransferase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4664</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003658">
        <property type="protein sequence ID" value="VDO40674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB01"/>
    <dbReference type="STRING" id="387005.A0A183HB01"/>
    <dbReference type="WBParaSite" id="OFLC_0000466201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000466201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000466201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000466201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53509" checksum="B6AECB0BD3A22DD0" modified="2016-09-07" version="1">MRFHRLPSRNLKVPESSKLCPGAGAVHDIHLSEVPEEEICVLAEPFVAFSFDFEDGPSIKYNETLIKTFDAQSDGRFEAILMWWELDMDGTGQNILSTAPERWNTEAKWRDHWMQGVYYLPQSIQVRKNQKVSVHCSHDEFSFWFSATQNESHTFEPNYCRCKTHVACSRTAIYRLNELDEDLDFDHFLKENFTGKSVVNLDDGSLISLLLAKYAKTVRIVQPNVHFVEVISAYIAENDIQNVQICEDYASVPSSEVDVIVSEPFYLFSFLPWHNICFWFMAHKLLISPESRNLSLSPREGIIYAMPVKFDDLWKIAAPFGIMEDFDLTPFDDVINKARRAVDAMVEPQPLWEYPSIITGEPVIVARFDFNASPTRESFVAKIISSLIGTNAIVFWMDWLHNGYRLTSGLLNSPEIGKRPSWSISQRQGVYFLPESERCLPFCSSTTVKVDFCPNAQFSFHFEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA2</accession>
    <name>A0A183HBA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RICTOR_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4763</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003787">
        <property type="protein sequence ID" value="VDO40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA2"/>
    <dbReference type="STRING" id="387005.A0A183HBA2"/>
    <dbReference type="WBParaSite" id="OFLC_0000476301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="1">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24526" checksum="BCBB7762ADB013F2" modified="2016-09-07" version="1">MMLSHMNEEIKSSENGLMKKDYSSTIFPANVCRALISNANCFFAIRPDRAKFEEKEDEFADSRNYYFNSCIPGVGLFIKIFIGWIVEFLTNAVFSDRLSTFVCQILCAWLDSPQLRTQAKLKLVLDRIFASVIEIELFEQKETIELDQQWLSNDSFQLRNFSRIFLNLLRTWAGLFACSTLDDQKTSIISALRWEFPAENFVITGSSYFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBB8</accession>
    <name>A0A183HBB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase, alpha/beta domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4780</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003803">
        <property type="protein sequence ID" value="VDO41016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBB8"/>
    <dbReference type="STRING" id="387005.A0A183HBB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000477901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000477901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000477901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000477901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38623" checksum="4455DA012825BCF7" modified="2016-09-07" version="1">MGQIYTVTAESPTSSCARIPAVLIHGFAAGVAFWAANIDDMAKKRILHCFDLLGFGRSSRPVFAKDPALAELQFVQSIENWRKRMGINKMILVGHSFGAFLAASFALEYPERVRHLVLVDPWGFPEKPLEIQEIFHFIPFPNISLKYSFNFNKLQNYPVWIRIATRAMSFFYPLAALRWAGPYGISVVKTLRPDLSLRFQCADPNAIYEYFYQCNAQNPSGEIAFTNMSFSFGWAKRPMLKRIIDLPSEVPMTFIYGSKSWIDSSSGIEVQNERRNAYVDVQIINGAGHHVYVDQKELFNNVLSDLFDKIDANEDMFLEKNVEKKIDSKSNGQDLNPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC88</accession>
    <name>A0A183HC88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS5101</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004212">
        <property type="protein sequence ID" value="VDO42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC88"/>
    <dbReference type="STRING" id="387005.A0A183HC88"/>
    <dbReference type="WBParaSite" id="OFLC_0000509901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000509901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000509901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fido" evidence="13">
        <location>
            <begin position="66"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="11">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="12">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO42065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000509901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27194" checksum="9E0A7C7675844213" modified="2016-09-07" version="1">MRESYFLHIYHTVAIEGNTMSLGQTRSILETRMAVAGKSIMEHNEILGMDAALRFINQSVVYVSYFTLQDILDIHSRVLGFVDPDAAGVFRKTQVFVGSFTPISADMIPGEMEEMVKWLNDDDSMLLDPIERAAIAHYKLVSIHPFIDGNGRTARLLMNLILMQSGFPPVIIPVEDRSDYYDTLTAANRGNLRPFIRFIARQTDATLQMYINSATTCDYREGSGKCSVSAAPKISTQQDESVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDP2</accession>
    <name>A0A183HDP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5604</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat EBI family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004902">
        <property type="protein sequence ID" value="VDO43708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDP2"/>
    <dbReference type="STRING" id="387005.A0A183HDP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000560301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000560301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000560301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000218">
        <property type="entry name" value="WD40 repeat-containing protein HOS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000560301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30107" checksum="AC7311CF76ADEAA3" modified="2016-09-07" version="1">MQKDDKNPPTNKDVTSLDWNCTGDLLATGCYDGYARVWATDGRLRYTLGAHKGPIFALKWNQKGDKILSAGVDKTTIVWDPLKGIQVQVFQFHSSSALDVDWMSDDTFASCSTDMCIHVCKLGCEKPLKTFQGHTNEVNAVKYDVYSRLLASCSDDMTLKVWSMNYENVVHNLKAHDKEIYTIRWSPVGYTLASASFDHTVRLWDIERGMCVRTLTKHTEPVYSVGFSPDGRYIASGSFDRSVYIWDVQVGTFFACITKYSYSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFJ6</accession>
    <name>A0A183HFJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6258</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005843">
        <property type="protein sequence ID" value="VDO45935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFJ6"/>
    <dbReference type="STRING" id="387005.A0A183HFJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000625701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000625701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000625701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO45935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000625701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12397" checksum="F066EAF6131BB34A" modified="2016-09-07" version="1">MNEAAEVIMEKQRSIIDRFVHLLSVGLALPVVEKINKMFRDGQIDISLVRYFAIEVLEIVAPPYSEDFIGVFLPIVSNSEIFDQNICDKIPAAKEFIDHCTPLTSEARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHG4</accession>
    <name>A0A183HHG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Surfeit locus protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6927</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006900">
        <property type="protein sequence ID" value="VDO48498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHG4"/>
    <dbReference type="STRING" id="387005.A0A183HHG4"/>
    <dbReference type="WBParaSite" id="OFLC_0000692501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000692501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000692501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO48498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000692501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19695" checksum="3489C23E14DF3919" modified="2016-09-07" version="1">MDQFRTGGRREFLRSAEDTADDILRHTKHFLPHVARLCLISTFIEDGIRMWFQWNDQRQFMQDSWSCGWLLATLFVMFNFFGQFIPVVMVMIRKRVGIACILLACVVALQTVAYHILWDLKFLARNVAVGGSLLLLFAETQEENKSLFAGVPQVGDTNRGKSAMLLTGMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHK6</accession>
    <name>A0A183HHK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MMPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6968</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006970">
        <property type="protein sequence ID" value="VDO48687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHK6"/>
    <dbReference type="WBParaSite" id="OFLC_0000696701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000696701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000696701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000696701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11572" checksum="1C6AA16A39FEC617" modified="2016-09-07" version="1">MLFATASFITLYCVLRPTKSTSQIAIASLVAILIPLFMFPVQSPFVLNAIEAVSLNRLMDRPPTLSNGIQSEISLVSDGISNFERLQRLAQLPLLTLSKNVGPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHL1</accession>
    <name>A0A183HHL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6973</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006978">
        <property type="protein sequence ID" value="VDO48700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHL1"/>
    <dbReference type="STRING" id="387005.A0A183HHL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000697201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000697201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000697201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000697201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22194" checksum="ED6B78169A5CC04D" modified="2016-09-07" version="1">MDEPALNYDILLPFPDHIQLSIDDYRNKLYEMIQQNKSYIRRIQHNRTITNNSKSNNTTGTTTPLTNTNGQAVVTNGRLSSVVRRSSSNIAIRTVKQSVTEPKAPIAQAECSDTDYDTSRSIYRSVSIDKPKNTNTVVTENKQLRERAQSAEIPQNGTICVQRTTTSSSKAQSRRRSQHRTKIFGSFRKSAQHFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ16</accession>
    <name>A0A183HJ16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007841">
        <property type="protein sequence ID" value="VDO51168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ16"/>
    <dbReference type="WBParaSite" id="OFLC_0000747701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000747701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000747701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000747701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19461" checksum="032ED33A0F60F0AB" modified="2016-09-07" version="1">MDCEKQCIFSPEQPQTLPPPKDHPCQPICHQNCQNVCSSSNLPTQKCMRSCQLQCQKAYNSLNPASQIIPLNLENSQIPVNPLCPTIPAISPIPNTPTATKEATCIDVCMPLCLPSCTTAQAQSLPIPPASEEVSSSNTIAPLSPSCIANCINVCMQQCLQLKLTINTCQSACQMQCANVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT1</accession>
    <name>A0A183HJT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIP49_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7743</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008278">
        <property type="protein sequence ID" value="VDO52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000774201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000774201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000774201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000774201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17469" checksum="FB44993602C442BE" modified="2016-09-07" version="1">MEACKTTRCAPYKCESIPAIHFRNIVVLINKRFRIKPARYKERFNSLLHDPLKTSIATQKVPGAYCGERNELLKSVKIKVLLSEGIFQQLLRKAFFMQQRYLYARDDCLDKCYVLGINLGCEMVPNDDMEVIKTAVFKHLEHMVFFQCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV5</accession>
    <name>A0A183HJV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF615 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7767</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008321">
        <property type="protein sequence ID" value="VDO52438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000776601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11941" checksum="7E5C6E3A4F674405" modified="2016-09-07" version="1">MFKNYLIQQSEYIRSLSFEFQGLLANTVTSQTLPNSLDRNIAIEKLETYFSRSTPDQIRQYMLRLRQAANRRLAEQAVDLISTLSSEECAQFLSDIDSDGAAGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKR6</accession>
    <name>A0A183HKR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8081</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008869">
        <property type="protein sequence ID" value="VDO53954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKR6"/>
    <dbReference type="WBParaSite" id="OFLC_0000807701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000807701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000807701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000807701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12913" checksum="38247907CD03993E" modified="2016-09-07" version="1">MVHKIPLQDKSMYGAYGIILGYIGMDTSIWGMGYHSRIHRHGAEDVILGHIDMVLFHIGTTVERNDMVHRVHYKAYSWDTIVRHQRTNSTAIEYTPEVTDRHTCTDRYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL15</accession>
    <name>A0A183HL15_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8181</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01009045">
        <property type="protein sequence ID" value="VDO54412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL15"/>
    <dbReference type="STRING" id="387005.A0A183HL15"/>
    <dbReference type="WBParaSite" id="OFLC_0000817601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000817601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000817601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046426">
        <property type="term" value="P:negative regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051985">
        <property type="entry name" value="NR_tyrosine_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO54412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000817601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27418" checksum="3F5F40698FE245F5" modified="2016-09-07" version="1">MKYFTSAFCLGVPHSTAVFIGFLQKVRGTGLLSEKEPTIVHCSAGIGRTGTFVVADSVLSMIEQNVEKIDVTNLVVEMRKSRMGLIQTPQQLQFCWKTIADALRQGVVTKNVKCEERKFINNKFGRDLLTVPNNHINGEVDEVPHLERSQANQMTTDLHSKSCGDLLTFRKRASTDSYETDKETKHARRKKRVEEMRARLLKCEGARKKWYYVAIGRPSVRYACAAVAVAFAIYYIYRLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLL9</accession>
    <name>A0A183HLL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHD_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8381</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009426">
        <property type="protein sequence ID" value="VDO55396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLL9"/>
    <dbReference type="STRING" id="387005.A0A183HLL9"/>
    <dbReference type="WBParaSite" id="OFLC_0000838001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000838001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000838001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO55396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000838001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17022" checksum="C912E0B9E1FBD182" modified="2016-09-07" version="1">MIPDGCVHLQLNGLVAIARKLGIDCVPAVVGWNHYRGGTHPILDGCVILKEHEDELREAWSKQYEKKEIAAKLKRTQRAIKNWRCLVKGLITLKKVRARFASRDRRLLHVDEKLENNEKTDKNATETTNGAGTLTWPPTDYSLPNINSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNI9</accession>
    <name>A0A183HNI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010734">
        <property type="protein sequence ID" value="VDO58525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNI9"/>
    <dbReference type="STRING" id="387005.A0A183HNI9"/>
    <dbReference type="WBParaSite" id="OFLC_0000905001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000905001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000905001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000905001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19266" checksum="59ED0CB20E96FEFD" modified="2016-09-07" version="1">MHLFQSGAIWQLIPHLFRYDYTLDEGGVEHNEETNKQSLHNKLARSGCEALACLAGFREGTPDNDGVQKSLKAMLTPYICRLMQQSEDNDRVLKVLNSNTEDPYLIWDNGIRNELLEFVEYHRTSTSNTSELFGGEFKLSAHEKELIIGDIFIRVFNEQPNFNIQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP95</accession>
    <name>A0A183HP95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS9306</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011272">
        <property type="protein sequence ID" value="VDO59619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP95"/>
    <dbReference type="STRING" id="387005.A0A183HP95"/>
    <dbReference type="WBParaSite" id="OFLC_0000930601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000930601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000930601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060158">
        <property type="term" value="P:phospholipase C-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF365">
        <property type="entry name" value="EGL-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO59619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000930601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5575" checksum="6A6D8F79B7F5CBE0" modified="2016-09-07" version="1">MFVDLNPDADKIIYSHFTCATDTENIRFVFAAVKDTILQHNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP96</accession>
    <name>A0A183HP96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9307</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011273">
        <property type="protein sequence ID" value="VDO59621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP96"/>
    <dbReference type="STRING" id="387005.A0A183HP96"/>
    <dbReference type="WBParaSite" id="OFLC_0000930701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000930701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000930701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF30">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000930701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14514" checksum="5B335F0394D25D07" modified="2016-09-07" version="1">MRLFIMTIGEFTIFYRSLNTCEERMMQMIGKFLFTIFELFISIMQFNLLIAMMTRTYETISRTSTEWKRQWAQVILFLELSLKPKERLIAMLKYSRPIGTDKTKRSFVVARKTTLLNLFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ56</accession>
    <name>A0A183HQ56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9619</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011998">
        <property type="protein sequence ID" value="VDO61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ56"/>
    <dbReference type="WBParaSite" id="OFLC_0000961701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000961701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000961701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000961701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10077" checksum="ABC1BA33D6AF032B" modified="2016-09-07" version="1">MTNDKALRKEVQSAVYPELEGGPLMHVIGCKNIVFTILFGYIFVPLINISYAKSEISSLSSNSNDIFSITETSTPKVLQKPANFISVALDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQR6</accession>
    <name>A0A183HQR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012492">
        <property type="protein sequence ID" value="VDO63703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQR6"/>
    <dbReference type="WBParaSite" id="OFLC_0000982701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000982701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000982701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000982701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4557" checksum="1CD92C512AB29009" modified="2016-09-07" version="1">MRKKGGDFTTDESKRWEGMMDDNNDRLMMIFNLSTTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQV5</accession>
    <name>A0A183HQV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4150 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9867</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012574">
        <property type="protein sequence ID" value="VDO64040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQV5"/>
    <dbReference type="STRING" id="387005.A0A183HQV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000986601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000986601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000986601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000986601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27670" checksum="4593F1136EC0DC6D" modified="2016-09-07" version="1">MPDQSVIPIFDKSKNKPVYSTSTSLYGKNIDIVEEWDSITPPPYKVIGTVIRAPNSAIHEVEEKIITIKESGTMYGSGNNGKDKLYVHGRAKELEESDNMFNSKRDEINRNSEEMILNHKTTTENSITKHNSSAHYFLNPNSTVTAEFTTSTFSPANDTFKKIQNKLDRWKFVSDLHIIDIVEFFNILMTLIAPNLSSEVTSTTHSSSVLDNSTFRNAKDEFSDEVMNTQTVKHFTGKALDETFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQX1</accession>
    <name>A0A183HQX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9881</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012603">
        <property type="protein sequence ID" value="VDO64155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQX1"/>
    <dbReference type="STRING" id="387005.A0A183HQX1"/>
    <dbReference type="WBParaSite" id="OFLC_0000988201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000988201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000988201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000988201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17838" checksum="59B72DAFAB41482F" modified="2016-09-07" version="1">MRQKENDFCDIHIQRSMTHSAISRGIDELDKTIPRSETMGPMLSSRSIPVCSTSESAKAAYNLVVALCDSAPLNYRCLVESLLELFYSEVVPTMNIEWEYMPGYSIRSPNSYVGLKNGGATCYMNSVFQQIFMIEPLRNVIINANFTDDMSVEEMVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSI1</accession>
    <name>A0A183HSI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rapid ALkalinization Factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013926">
        <property type="protein sequence ID" value="VDO68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSI1"/>
    <dbReference type="STRING" id="387005.A0A183HSI1"/>
    <dbReference type="WBParaSite" id="OFLC_0001044201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001044201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001044201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001044201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15447" checksum="F6299A3E31E1B4E7" modified="2016-09-07" version="1">MMAVENRNYGRMMFIYIFIASFLLISTHCFTALKHNSLGDIFNDDTISAKEPGGAEMKLPAKPVFLKKHGIEGLNYNLDNKSRPFIYCDFYDVSSCDPMERSCPTTKMCYASANDHRLGCMAALVNNSLTRVYPVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT33</accession>
    <name>A0A183HT33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10653</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014422">
        <property type="protein sequence ID" value="VDO70285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT33"/>
    <dbReference type="STRING" id="387005.A0A183HT33"/>
    <dbReference type="WBParaSite" id="OFLC_0001064501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001064501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001064501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001064501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10691" checksum="358261858A143E44" modified="2016-09-07" version="1">SRSTRRPAGQTTQFRGCASTPDTLFVIDSTSSVRHFFDDHRAYVIEIIGLILPEFDNETMIGVIEYSSPLRRRVKLPFTAHKNRRKIIEAIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT96</accession>
    <name>A0A183HT96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10707</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014566">
        <property type="protein sequence ID" value="VDO70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT96"/>
    <dbReference type="WBParaSite" id="OFLC_0001070801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001070801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001070801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001070801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12633" checksum="78EC6DC8F101CBCC" modified="2016-09-07" version="1">MESLKDLEGTHMQIIRKIQVKVKVDITMQVKQPTAAERRLKIYSFAMRLAIHYRMGLVGNGIKYIAKKGKGHINYSHRRIVTIRLHLPLPCCLHAHIFKTFGSFLTTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTE5</accession>
    <name>A0A183HTE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014718">
        <property type="protein sequence ID" value="VDO71122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTE5"/>
    <dbReference type="WBParaSite" id="OFLC_0001075701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001075701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001075701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001075701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10440" checksum="F7F419ABABE49B1A" modified="2016-09-07" version="1">MNIGTGIINQTMHHRIPTPKAYYVPSTDVVTSIVLPTILFCIAMVVAMIIGIKKCKQWELDKIVEMRRTRRVVQRITARLREKNFRTIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTQ6</accession>
    <name>A0A183HTQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10865</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014985">
        <property type="protein sequence ID" value="VDO71961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTQ6"/>
    <dbReference type="STRING" id="387005.A0A183HTQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001086801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001086801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001086801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001086801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8917" checksum="C6112F975B2BE32C" modified="2016-09-07" version="1">MGQRIVVSDSQESVHFMRYKKQDGQLSIFCDETSPRYVTCVCLLDYDTVAVGDRFGNIAVVSLISKIHLFKLIANDSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTS5</accession>
    <name>A0A183HTS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10885</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015035">
        <property type="protein sequence ID" value="VDO72121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTS5"/>
    <dbReference type="STRING" id="387005.A0A183HTS5"/>
    <dbReference type="WBParaSite" id="OFLC_0001088701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001088701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001088701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001088701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5958" checksum="85886EB999178478" modified="2016-09-07" version="1">MNEYDCRRLKERSIVMASGGISVENPDNPENNLLDCNRISDNDAFQENQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU55</accession>
    <name>A0A183HU55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015346">
        <property type="protein sequence ID" value="VDO73082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU55"/>
    <dbReference type="WBParaSite" id="OFLC_0001101701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001101701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001101701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001101701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17137" checksum="BA0C0BF6C6CD93A6" modified="2016-09-07" version="1">MEKMPENHLAESELYREACRHEIIARIKFEKEQYEEAIEYYQNALKILMICGDNHLEMSDKLAKIINVHWKMGETFEALAIQTNDLEPIKNEIAVQTKLLQYRPYDRNLRLKRSALWKILQNRKYALIGKKVFFSWLFFHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUF2</accession>
    <name>A0A183HUF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inactive rhomboid protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015638">
        <property type="protein sequence ID" value="VDO73982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUF2"/>
    <dbReference type="STRING" id="387005.A0A183HUF2"/>
    <dbReference type="WBParaSite" id="OFLC_0001111401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001111401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001111401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001111401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18267" checksum="6D569F5C69119075" modified="2016-09-07" version="1">MLSLIATLARWKEDSPGPESRLSGAVCGQDPRYCENPVSVKPYEWPDDITQWPICKQRTLFVPENVVHMQCEITGRPCCIQLHGQCRITTRDYCDFVEGYFHENATLCSQVTLLSLLLLLTNVSFRMPVTPKIGFHNSFSNIVQEESLLNFLAKDNEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUG7</accession>
    <name>A0A183HUG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11128</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015667">
        <property type="protein sequence ID" value="VDO74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUG7"/>
    <dbReference type="STRING" id="387005.A0A183HUG7"/>
    <dbReference type="WBParaSite" id="OFLC_0001112901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001112901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001112901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001112901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9346" checksum="B189FF680857E2B2" modified="2016-09-07" version="1">MLTDVGEKIRASTKSANLRHVLVFKGPEMEYFIGLVRRNEILWDGSFEEYHTRTNKKKQAWEKIAAEMSNDLKQVDGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUT4</accession>
    <name>A0A183HUT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vegetative cell wall protein gp1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11247</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016013">
        <property type="protein sequence ID" value="VDO75069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUT4"/>
    <dbReference type="STRING" id="387005.A0A183HUT4"/>
    <dbReference type="WBParaSite" id="OFLC_0001124601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001124601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001124601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552644" evidence="2">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001124601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25677" checksum="8A908D54C5C6A663" modified="2016-09-07" version="1">MMLHFWFIAVFINIVFAECGNRPYPKKPCPETPQPPCAETTDPYSPQEESEPPPEEPELPPEESDPLPEEPQPPPEEPQPQPKKPHELPPQAAIIHPPPFVSAKCPPKLCPEPPPPPPPCPPPNCPTLPPPETCPPCPSPPPPVPCPPPVTCPPPPPPPTCPPPPPPKRCPPPPPPPPPPTCPPQYCPPPPPPPPCPKPLPPKPCPLPPPPKPCPPPPPQVTCPPPKPCPPPPPPKPCPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV44</accession>
    <name>A0A183HV44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016322">
        <property type="protein sequence ID" value="VDO75864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV44"/>
    <dbReference type="STRING" id="387005.A0A183HV44"/>
    <dbReference type="WBParaSite" id="OFLC_0001135601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001135601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001135601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001135601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8235" checksum="8C3A734792687AB4" modified="2016-09-07" version="1">MNSEDVSGARLLRDEGQELISSQDVELTASLLPKCDELGRMADALSGALERRGQVLRLSKDMHQQIYASDFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVA8</accession>
    <name>A0A183HVA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11419</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016464">
        <property type="protein sequence ID" value="VDO76280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVA8"/>
    <dbReference type="STRING" id="387005.A0A183HVA8"/>
    <dbReference type="WBParaSite" id="OFLC_0001142001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001142001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001142001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001142001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12793" checksum="87EC9C14089121D8" modified="2016-09-07" version="1">MNKKHISEKKLEKIVVNARNKKVVNINVEKPDSKLSWYFICSPGDIDFCVLFEGNEVWPCFRISTEFRAEYNEIMCKKAGIYQLSFCNRHGYIRSKCIQYHVDVVEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVY4</accession>
    <name>A0A183HVY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3265 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017091">
        <property type="protein sequence ID" value="VDO78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVY4"/>
    <dbReference type="STRING" id="387005.A0A183HVY4"/>
    <dbReference type="WBParaSite" id="OFLC_0001164601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001164601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001164601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001164601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11062" checksum="592D24F86B32AA4A" modified="2016-09-07" version="1">MAHCFCRQKENNLFKPPVLNVQSNYLDEQCITVDENDKPLRPESKRFCHSAETYISWAVFSSNYLISAIKRACNFSTSLKFGRYVYCVLTLTGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW92</accession>
    <name>A0A183HW92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017416">
        <property type="protein sequence ID" value="VDO78959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW92"/>
    <dbReference type="STRING" id="387005.A0A183HW92"/>
    <dbReference type="WBParaSite" id="OFLC_0001175401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001175401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001175401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001175401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9855" checksum="E41EE5BD5C97C8C6" modified="2016-09-07" version="1">MTKSEIFISGVEKKKIAIQEKKNCDDGSLRNTLSKNENDAYKEIGEKKFESNGDQSNKKDKKEKQSKKQHQRKKSRSKERPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWH2</accession>
    <name>A0A183HWH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017610">
        <property type="protein sequence ID" value="VDO79562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWH2"/>
    <dbReference type="STRING" id="387005.A0A183HWH2"/>
    <dbReference type="WBParaSite" id="OFLC_0001183401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001183401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001183401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001183401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10567" checksum="A034AAC0FA19F982" modified="2016-09-07" version="1">MGEVLIDFTIAQLDDEPFLYTLVDMDDDNPLRAKLQKRRLNIYHATTRSLSEMGHYPNARQQRAVDYTTAAYDAYQPGSRQVPFLIQLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXC4</accession>
    <name>A0A183HXC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12138</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018463">
        <property type="protein sequence ID" value="VDO82224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXC4"/>
    <dbReference type="STRING" id="387005.A0A183HXC4"/>
    <dbReference type="WBParaSite" id="OFLC_0001213601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001213601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001213601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001213601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12306" checksum="79B636DC4D74E654" modified="2016-09-07" version="1">MTNSTTATTLHPLVQWAQRDKLLYLTIEIDNVTDLQITDKSLHVKGTYGGSKAHYEATLDFYAGVKPEDYRKIDNGRHLELVINKEASQWWPRLAKSNTKEEKEAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY13</accession>
    <name>A0A183HY13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock 70 kDa protein cognate 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12375</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039832">
        <property type="protein sequence ID" value="VDP11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY13"/>
    <dbReference type="WBParaSite" id="OFLC_0001237601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001237601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001237601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1360"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001237601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1393" mass="152764" checksum="0B2643C58A4FAE16" modified="2016-09-07" version="1">MVAERWGKRQRLLHSRLSENSRLCKKHEVCLLIESREIGVRHAMAVPRMHSTCTFIVHRPVVIMGKSNAVGIDLGTTYSCVGVFMHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFDDPAVQSDMKHWPFKVINADGGKPKVQVEYKGETKTFTPEEISSMDAVVTVPAYFNDSQRQATKDAGAISGLNVLRIINEPTAAAIAYGLDKKGHGEHNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFVNEFKRKNKKDLTTNPRALRRLRTACERAKRTLSSSIEIDSLFDGTDFYTSITRARFEELCADLFRSTMDPVEKALRDAKMDKAQMHDIVLVGGSTRIPKVQKLLSDFFSGKELNKSINPDEAVAYGAAVQAAILSGDKSDAVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKTSQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAQDKSTGKHNKITITNDKGRLSKDEIERMVEEAEKYKADDDAQKDRIAAKNALESYAFNMKQTIEDEKLKDKISADDRKKIEDKCNEVIRWLDGNQTAEKDEFEHHQKELESICNPIITKMYQSAGGMSGGMPGGTPGGGAQGSGPTIEERPMKPVLHVHVCMSSLPYKWIERFPSSIDESSGCVVQLAWGMLRRLVKGDVDVRVVTVRGSSKMSKNAIGIDLGTTYSCVGVFMHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFDDGSVQSDMKHWPFKVINAGGGKPKVQVEYKGETKTFTPEEISSMVLVKMKETAEAFLGHAVKDAVITVPAYFNDSQRQATKDSGAIAGLNVLRIINEPTAAAIAYGLDKKGHGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFVAEFKRKHKKDLASNPRALRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTNITRARFEELCADLFRSTMDPVEKALRDAKMDKAQVHDIVLVGGSTRIPKVQKLLSDFFSGKELNKSINPDEAVAYGAAVQAAILSGDKSEAVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKTSQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAQDKSTGKQNKITITNDKGRLSKDEIERMVQEAEKYKADDEAQKDRIAAKNALESYAFNMKQTIEDEKLKDKISEDDKKKIQEKCDETVRWLDGNQTAEKDEFEHRQKELEAVCNPIITKLYQSAGGMPGGMPGGMPGGMPGGAPGGGSTGGGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ71</accession>
    <name>A0A183HZ71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12783</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039931">
        <property type="protein sequence ID" value="VDP12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ71"/>
    <dbReference type="STRING" id="387005.A0A183HZ71"/>
    <dbReference type="WBParaSite" id="OFLC_0001278401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001278401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001278401"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF7">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="265"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001278401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44993" checksum="36129669439728C8" modified="2016-09-07" version="1">MGSFDNLLATWACVLERKEETDRREKYVPSEGTFLFDSSQSCKIRKMPFIGKDWRAPGETWVWCSNTDGWEQVKLRPIQQVDEAGDATRSPVCSSLVKITRNVSSMSLSSNDENSPRSDTDDSESDDWIPHCFVKTGKSKEFVGCTSMSEAFHRLDLARAVSDVRRFNYICKVVQILVQEKLQNLSATARKALLSIIKAIVLICVEKDLHISIARSLVCDFGTGLEGHLYGSPQLVSKQLNMIGDLLELISERRPRTLADSDEESVTFMDLPREILSVILRKLPDHVSLLEVAKAHEVLDAIVEKEEQLWASLCNFHFTQEQTKKIKRDSISWRHAFFELKKYCGLREFYADLIHLCCHCKAIFWKDHGHPCISKDTPSVRVTPQQFVDMLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZI7</accession>
    <name>A0A183HZI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12899</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039968">
        <property type="protein sequence ID" value="VDP12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZI7"/>
    <dbReference type="WBParaSite" id="OFLC_0001290001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001290001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001290001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001290001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10595" checksum="59787F66DC72D201" modified="2016-09-07" version="1">MGKLFVLWNVNSNPFLQTHDFRYEKWSFDVKYHLGWEFIYSCCSIIMTLGDYDLDRFVIVSSITFIRLKRPAPNTHNLERLLRHIIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZN0</accession>
    <name>A0A183HZN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12942</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039985">
        <property type="protein sequence ID" value="VDP12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZN0"/>
    <dbReference type="STRING" id="387005.A0A183HZN0"/>
    <dbReference type="WBParaSite" id="OFLC_0001294301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001294301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001294301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001294301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="846" mass="96463" checksum="B90144EB948CBD0F" modified="2016-09-07" version="1">MVDEYYRLSDVFETVSIFAPDEKVTCVDGTSRTLFVGTSQGRILLMDLSSKNVINALQLSVVMFKEFSRLEKNVPVARIVAATALDYLIVLSASTIFNVKITTLKPISSSSASNIAHLALNKDPVIADPFALQLALVTNNRYILVCESKADSLEIQKEIRTEENVVALSYNKYCICYALPNAYFVHNILENKTLFLFPYDSHTIRPIIINTDADEFLVNGMQGLGVFATSEGVSSRPPLFWGLSSIVSFAYRSPHVFVLTASSITVYRSASIFSSEQSVVLQRWPFTTGMLLECIDGQLYVCSNANICHLEEILWFDRAQALADSGELDEALRLAENVVSNGQYDEAEILKFNKLRQKVALVLFKRGEFEKFLELAVLSELDPRTVLISFRFLLPFPSGFRSELTKEATESSEESFDGSVAKESIQLTTFLEHYLRTIRKLHWVAGFFRISKILVSIFEPNAHKDIDAMLLRLISLRQDALDAKDMSLNLHCTFDDCNEWMRKHKRRKFLITVAFCLLDYNNALTVSRELYNENLWDDGIAELCLQFFPRFDSEQMILEWVEFLLRTHQNDIIDGLKRCPVKLDHSKIVRILQQDRSTLIKYLEEIKSLQNVEFHSMLFSMYIDEINMLLREGKKNEKSCRKGLRTFLIQPNKLNLLDTHAALKNYSHFAVELTLLEGVKEKGSVECLEKLLIDHKDYDAAELFCIHTDTSEHVLRLTLLKFYLRNVASQPEFRSRIINLLNTSGLTSNGAEVLQDIPKEWSLSSILCFVEGTVLTVEDRSHYQQLKKKVFITLKSRFKEALKAAHLCIQIDEKTVCTACGAPISNEDAACYPHANQIFHRKCLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I045</accession>
    <name>A0A183I045_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS13107</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040047">
        <property type="protein sequence ID" value="VDP12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I045"/>
    <dbReference type="STRING" id="387005.A0A183I045"/>
    <dbReference type="WBParaSite" id="OFLC_0001310801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001310801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001310801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000448">
        <property type="entry name" value="LIM/homeobox protein Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001310801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26336" checksum="3BF3A7B4E03FE93D" modified="2016-09-07" version="1">MDIRKLFRLFGVKCIRCGLPVQSTDYVYRVFTSIYHLHCFKCFCCGHLLKKGDHYMLMDGQVICRPDYEHLLCQAPICQSHLYFDQNDSNRKTPKRPRTILNTQQRKAFKLAFEKTSKPCRKVREQLAKETNLSVRVVQVWFQNQRAKMKKIQRKLGVSEANDIVCSEMDIKSNDELKSNCDSANELDSENEDVEIDDVGSNEEKSKESNNPIAQLFHMHATYFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0I4</accession>
    <name>A0A183I0I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13246</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040108">
        <property type="protein sequence ID" value="VDP13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0I4"/>
    <dbReference type="WBParaSite" id="OFLC_0001324701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001324701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001324701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001324701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7728" checksum="D7EB5D237BBA474F" modified="2016-09-07" version="1">MESPKVSTEYMENKLAKTNNSKENNSCLTFPLLSRYAKCHLRLMHSRNIATREKEQAGKGEEKVLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0L3</accession>
    <name>A0A183I0L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040120">
        <property type="protein sequence ID" value="VDP13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0L3"/>
    <dbReference type="STRING" id="387005.A0A183I0L3"/>
    <dbReference type="WBParaSite" id="OFLC_0001327601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001327601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001327601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001327601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61684" checksum="4F951BF41FBE97CF" modified="2016-09-07" version="1">MCVTFVYLNDKAIDDPKSYQLIVLNNRDELFDRPTLPPAWKDGILCGRDQADPYGGTWLGMTKNGRLGNILAVLENPSDEIPCAITRGLDLTCKIVYEYLKSEMPPESYVAEQLSKEAQQYNGFNVILFDRLFNEEIERKTYFGFQFSNRYDSPTAVFGSGVYGFGNSALGKPFKKITYGLRLFEEKLKILDDENVNEQELMKQFLDILIDQTSHYPDEQLISQKDQDKENCKLMSQLFYKLPEPLRYGTRFNAKYKLILLNNRDELLNRPTSTARWENGILAGRDEKETIRGTWLCMNSAGRISNLLTITVPIHEMKSSSVTRGVIPVDFVKSNKKPEEFCKLLISTCKCSNVFQNFKNIRFFFNSLEIKLHFRNERDQYEVAGLTYQSEDNIEVTRYPPGIHGFSNSPSCEPFKKVRRGVDKVSSIIEEINTENLSEAEIIERLLQLATDKYQCFPDDQIKRRCGRSNELCKYRAAIFVRYPDGIPYGTRSHTIIIVDRNNRATYYEKSMETKTGKASEATWTEQIFHFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Q6</accession>
    <name>A0A183I0Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040141">
        <property type="protein sequence ID" value="VDP13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Q6"/>
    <dbReference type="WBParaSite" id="OFLC_0001331901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001331901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001331901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001331901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11841" checksum="F5C45BB79B8698C4" modified="2016-09-07" version="1">MVFAENWWCTLAANGHDSQIKDNKSVQYDYEFGHASVILEEAYSAGVRGYTFNCQPPRNSCATDMRANSLDLAEESWQTACTSPHSSLFPPRSCVEWIISCHACVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I189</accession>
    <name>A0A183I189_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13501</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040232">
        <property type="protein sequence ID" value="VDP13917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I189"/>
    <dbReference type="STRING" id="387005.A0A183I189"/>
    <dbReference type="WBParaSite" id="OFLC_0001350201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001350201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001350201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF12">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="73"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="181"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001350201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32919" checksum="952240152B3D7CF7" modified="2016-09-07" version="1">MSTTSQKLSESKLKTGKSTKSSEELKSSPLIRSVERLSSRPRRSSRLQRFQKLPTVQVDRSIARNLDEKIDDGLKIEPKSLNWNISGGVQRVYLTNPSNERRAIKVKCSDNHLYRVNHVFGFIEPGQMFTIDVVRQNGGAKTDKMAMETDKNASVLFKKLTVYPLLVLPLTVNNHHKERDDLKMEPVELHWNTNGGVQKVFISNPTKMRRALKVKCSDNDLYRVNPVYSFIEPGQVLAIDIFRQNGGAKVDKMVFLAAMAGKDEKNPRSVFQDDLPKPMMVLPLIASPINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1V0</accession>
    <name>A0A183I1V0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS13712</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040351">
        <property type="protein sequence ID" value="VDP14464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1V0"/>
    <dbReference type="STRING" id="387005.A0A183I1V0"/>
    <dbReference type="WBParaSite" id="OFLC_0001371301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001371301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001371301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP14464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001371301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19270" checksum="4FAC7296216C7F4E" modified="2016-09-07" version="1">MVRADCSLTHCEEDTKQAVFSYILAIRDLLNGKSNRWNLALTQEAFEAALNATQSARIRGHLLTAQEKPIPINIGDQFVDGDRKAMGYIGVALQSAFYELLHGTSFTKSLTDAISRGGDTDTNAAIVGALLGARFGFDNIPVQWINTVKESKPRANFNTIDHNVERIVNNLLMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2E7</accession>
    <name>A0A183I2E7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13909</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040462">
        <property type="protein sequence ID" value="VDP14979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2E7"/>
    <dbReference type="STRING" id="387005.A0A183I2E7"/>
    <dbReference type="WBParaSite" id="OFLC_0001391001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001391001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001391001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001391001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6315" checksum="99C255228B72CA74" modified="2016-09-07" version="1">MDETAYEAFIKYSKNTHALGRVGNPDEVANAIAFLASSASSFITGASIPVDGGRHAMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I323</accession>
    <name>A0A183I323_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14135</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040617">
        <property type="protein sequence ID" value="VDP15605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I323"/>
    <dbReference type="WBParaSite" id="OFLC_0001414301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001414301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001414301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001414301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12741" checksum="AF210FCD635E966B" modified="2016-09-07" version="1">MRAERRAARVENSRLRARRSFSTISDLLRSEQNERDRVRMAESRKRKTGDQHQAWFRAQQSRYYNRLASRISLDVLFFYYGYEKAWRHLLYYKSYEIEIPLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I347</accession>
    <name>A0A183I347_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14159</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040632">
        <property type="protein sequence ID" value="VDP15731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I347"/>
    <dbReference type="WBParaSite" id="OFLC_0001416701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001416701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001416701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000377">
        <property type="entry name" value="LIPaSe related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF3">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001416701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31138" checksum="D351D0470005DEB4" modified="2016-09-07" version="1">MWLSLLLIFDSVRADFTPHFRSFIHNNYGVAIAQALERTDLGKTASFGGKQSNEDKLNNQAVILIHGSGDRITRLQRMVDHLLDKGYNRSEIYGTTWGDGELTSVGMVDMKCSYVKQIRSMIIAVRQYTGTRVDVIAYAVGSPLARKAILGGECVDTREILGPPITELIDTYLSVAGANYGIVSCFIPIPVGACNRRTGLHCQSTFLRDINGQTGYEGTFIFSIFSDSDEKIGYRGCNTLLSPIRGETGFVKKEFLSHDLTIDKTYEMQRNFIRKQRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3A2</accession>
    <name>A0A183I3A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14214</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040680">
        <property type="protein sequence ID" value="VDP16011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3A2"/>
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        <property type="gene ID" value="OFLC_0001422201"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030833">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11959">
        <property type="entry name" value="SH3_Cortactin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hematopoietic cell-specific Lyn substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cortactin_SH3"/>
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        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="637"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP16011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001422201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="694" mass="79018" checksum="71DBF32477ABFDD7" modified="2016-09-07" version="1">MWRAQVATNLTKEEKLKHLEEVDDWDTDPDFVNDLNERESRWGAKTVEGSGHQESVSLDQLRKEVIESDNLIRAKKLAEMPKASEGYGGKFGLQKDRIDKCAETWEYAGKVDKHASQKDYAKGFGGKYGIELDRKDKSALGWDEKMVLSKHGSQIDYAKGFGGKYGLETDRKDKSALGWNEQEKLPQHESQTDYKKGFGGKFGIQEDRKDKSAHGWEEHEKLQQHESQIDYKKGFGGKFGVQEDRKDKSAVGWDEHEKLATHQSQIDYKKGFGGKFGIQKDRKDKSAVGWDEHEKLHQHESQTDYKKGFGGCFGLQEDKPDKSAVSYQQCEEPTQHEKFGAKFDIQSDLHDKGAFDYNFSEEQTSRRNILPVAPKGRALNLRAKFEQLSVTENDEKVQQERERRKREDEELCKQQQKEEEERQKKIAEEWKRREELEQQMDPETIREEIWQHEQLHHIGGASKRPSRAPAGAVAIMPGVAQAPSKREISIEPHISSTTGNVSAVLEKSPSHPVKLPLFNPSSNKIFNEMERHVIHNNERNEDIQNCKDKSRDNFAPLSIHSEIKEIATEKGTLNGNRYDVVPGDDVVPPPAPVTQSPLLETTIMHGGKHEEVIVEKEQSKIDTVGDPLSSPTHPLSSTGLTAVAIYDYQKQDDDEISFDPDDIITNIDQVDAGWWRGLCNGQYGLFPANYVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3K6</accession>
    <name>A0A183I3K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS14318</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Synaptic cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040762">
        <property type="protein sequence ID" value="VDP16481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3K6"/>
    <dbReference type="STRING" id="387005.A0A183I3K6"/>
    <dbReference type="WBParaSite" id="OFLC_0001432601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001432601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001432601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552754" evidence="11">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP16481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001432601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13575" checksum="286A51AEF41AB3BB" modified="2016-09-07" version="1">MVNLIELVISLISLLIPMIYCNEDAKRLHDDLMANYNKHRRPAPAANKPITIKLKLRLSQIIDVHEIDQIMTCSVWLKQVWIDKKLSWNPKNYGGVSVLYVPYEMIWVPDIVLYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3X3</accession>
    <name>A0A183I3X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14435</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040854">
        <property type="protein sequence ID" value="VDP17034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3X3"/>
    <dbReference type="STRING" id="387005.A0A183I3X3"/>
    <dbReference type="WBParaSite" id="OFLC_0001444301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001444301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001444301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF108">
        <property type="entry name" value="FASCICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="167"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP17034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001444301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38121" checksum="AD0BED0B04909FD0" modified="2016-09-07" version="1">MVNVLSSAQDLTRSAGFPTVALRGIAVNTNWTGATIMCQAALNGGTIDSAPAVIDVRYLKQPHVVDTSGQGPALIVNQGYRFYVECIRTNDGLCQQNGRRKTLRCAVQSHPPATVFRWLKNGIPVSGNGADITIGTEMIGQSIQCSANNGLFSDGEMPISQAVQIDPYTSARLVQDNFQTMQNAAPFQTGNRIDMNQQINLGCQVEGNPRPVVFWKLRKSSGQVVDAACPQGFDGQYHEVPSEQRGQAAYVTNIRLNAICSLRIANYTFSGQYWCAACSYVSQGPPECSPSLDSPGTTYLNVQVQGPPTQSDTSPSVQKVSIFSFVIFIITNKWYFFACCTYKTFGIIGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4I1</accession>
    <name>A0A183I4I1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14643</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041035">
        <property type="protein sequence ID" value="VDP18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4I1"/>
    <dbReference type="STRING" id="387005.A0A183I4I1"/>
    <dbReference type="WBParaSite" id="OFLC_0001465401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001465401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001465401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001465401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19569" checksum="299D7151B584BC4E" modified="2016-09-07" version="1">MTFLQFMREANINFSLYVSIRPPSLLPTACDYSVFKKDIQPMWEVPENAKGGRWLITIDKSRHHDLLDVIWLEVLMAVIGQQFGKYTADICGVVVNIRNKGSKISIWTTDCNNDESNCKIGEILKQKLINPDIDSKIQRPIFDVLRYEDHQEVQNKSSSSVKAKHIITASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5E0</accession>
    <name>A0A183I5E0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14952</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="UZAJ01041400">
        <property type="protein sequence ID" value="VDP19723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5E0"/>
    <dbReference type="STRING" id="387005.A0A183I5E0"/>
    <dbReference type="WBParaSite" id="OFLC_0001496301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001496301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001496301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP19723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001496301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="40170" checksum="9ECD5DBCACCB62D8" modified="2016-09-07" version="1">MLFLRMKSKANPKSYYAWFYRLWCFKQLTNPDIAAELAACEKFLNLDGRNFHCWDYRREIAEFGAHSAEEELKFSDRLIDANFSNYSSWHYRASLLPSLFPDPEKQMIVNQQTLYNEYQKLQNAFFTDPEDQSAWIYAEWLLLSDQKKKKCELVSMSSEMMNRKAFRAKNSYRFEIAGELAECQLRPSLSEPYEIIDMERGYVNFEEIYQIYHIRCKPVSEARRHIIEKVMDNCQELLKELEVEQKKEILKWPLLTYTFAILELEPIEMLSTILTNLEELATKVDPQRCQMYEEMAMNLRISQKLREKLGDVHRIDILFRQVSGHVVGELKLDNLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5R5</accession>
    <name>A0A183I5R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DZF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15078</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041577">
        <property type="protein sequence ID" value="VDP20282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5R5"/>
    <dbReference type="STRING" id="387005.A0A183I5R5"/>
    <dbReference type="WBParaSite" id="OFLC_0001508801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001508801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001508801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001508801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28776" checksum="CBAFDB3E8C87D87B" modified="2016-09-07" version="1">MSEVNVATETVNRQSDQDDDDGIDRSTPESRTERALLIQRGLLTEQQWYENSEIVKIFVKLENILRAICKRMNLSAKVDSSIKLEADNPTTEKFSLVQRTGAEVFKCSVVLLGESVIQTEVSPVTMKYPKMPGGVYRAVAQPDVQWKLQQIQDADNYFVQALSLLVKDLKWIRQISPNDMGKISSTVVTTITKVTNLIGQARSTLCIPEKRTLLELCNSVITRCFNPPLPSDLVFSYYISADRFVCAAYQVASKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5W0</accession>
    <name>A0A183I5W0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15122</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041642">
        <property type="protein sequence ID" value="VDP20494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5W0"/>
    <dbReference type="STRING" id="387005.A0A183I5W0"/>
    <dbReference type="WBParaSite" id="OFLC_0001513301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001513301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001513301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001513301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13559" checksum="1876ABE0BDE2569C" modified="2016-09-07" version="1">MWEFESTNWTTEIGFNHETFMFPNDRYAYMILLAVFDYRSARYWRVRMWGESPFDDVRMNDTTVEPLTNNPKGFIYVTSLINGWNRLKIKFQPYVKKKKWLMMAQVSIIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6A6</accession>
    <name>A0A183I6A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15268</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041854">
        <property type="protein sequence ID" value="VDP21090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6A6"/>
    <dbReference type="STRING" id="387005.A0A183I6A6"/>
    <dbReference type="WBParaSite" id="OFLC_0001527901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001527901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001527901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF17">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001527901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39652" checksum="1BE41E40A566CB60" modified="2016-09-07" version="1">MGEYASAAVTCDHGLCSEIGRNILLRGGNAVDASIASLFCLGVTNPQSSGIGGGFIMTLYNRTEEKCIVIDARETAPEKADRNMFIDDEFGSKHGFRAIATPGEIAGYWLAFKRFGSGKVLWYDLIKPSIDLCRYGVPVSKYLAYVLSVKEKHFRTLPSMQSWINNATNKVFVAGDIIKRPELAKTLERLALSPDPEELFYRGDIAEALVKEIQKNGGIITLNDFAQFKPTVHEYPLVNDHFSDDLAMCGPPPPSSFASTQLIISLMARFYGPKTNKEILRRDPLFYHRFIEAQKFAYAQRTLMGDEAFVEEAKKLAKNMTTKSYTDWVFSRMRNTTQPTEYYGGIREQVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Q2</accession>
    <name>A0A183I6Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042093">
        <property type="protein sequence ID" value="VDP21761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Q2"/>
    <dbReference type="STRING" id="387005.A0A183I6Q2"/>
    <dbReference type="WBParaSite" id="OFLC_0001542501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001542501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001542501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001542501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11684" checksum="B12161A9CD5B0166" modified="2016-09-07" version="1">MRILNTNRSNLPSSNQNRRQASEKLNWNLKRHIKPINATNDLSQKSQPLAHLDTGGSNFDRFIISERKNDNPILDWIIGKFSKKGEILIIFFFFFLNIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7B0</accession>
    <name>A0A183I7B0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS15622</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01042478">
        <property type="protein sequence ID" value="VDP22891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7B0"/>
    <dbReference type="STRING" id="387005.A0A183I7B0"/>
    <dbReference type="WBParaSite" id="OFLC_0001563501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001563501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001563501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDP22891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001563501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22570" checksum="6D50183DF5AE4197" modified="2016-09-07" version="1">MGRGEDAISITVAIVIVVTVGFVQEYRSEKTLEQLNKLVPPICHTIRDGRELQFLARELVPGDIVLLNVGDLIPADLRLTESYDLQVDESSFTGELEPRHKYVRPLAAGSGTFDHVDNVVYMGTLVRAGHGKGIVIGTGSHTRFGEVFKMMQAEEAPKTPLQNSMDYLGKQLSLYSFAIIIIIFFIGLFQGRNTLDMFRIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7I9</accession>
    <name>A0A183I7I9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15701</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042658">
        <property type="protein sequence ID" value="VDP23307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7I9"/>
    <dbReference type="STRING" id="387005.A0A183I7I9"/>
    <dbReference type="WBParaSite" id="OFLC_0001571401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001571401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001571401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF139">
        <property type="entry name" value="SEMAPHORIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP23307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001571401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19012" checksum="847D44EB45FEA514" modified="2016-09-07" version="1">MLDIENVFTLGRLAYRRLLVDPQSASLYVGANGHLFRLWAYNINITESTDGLYAHVELPVSRADAEECRRAGHAECTNGVRLMFLKEEPDFVASFDIDRYVYFFFRELAIEREHCERTVFSRVARICKKDIGGKNVLRQVWTTFVKARLNCSIASKFPTYFNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7Z9</accession>
    <name>A0A183I7Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15862</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043077">
        <property type="protein sequence ID" value="VDP24369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7Z9"/>
    <dbReference type="WBParaSite" id="OFLC_0001587401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001587401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001587401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001587401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="7292" checksum="F4101F4F9F0C8F40" modified="2016-09-07" version="1">GWGGEGSGGWGGPPSQGGWGAPSGGAGGEINPRLFCAGWGQGGGQGGWGTGGQGAAQSWGGSGGQSGGGGWGGRGAVYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UZA2</accession>
    <name>A0A3P7UZA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000390">
        <property type="protein sequence ID" value="VDO27677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0D5"/>
    <dbReference type="OrthoDB" id="5842160at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="177" mass="20446" checksum="84B03F15AE08FD4A" modified="2026-01-28" version="1">MPRDSFRCCVISDDGIKRWFVYFDKPRSTMVVTDGMASTYEKMMTTKDRIEFAGNVSESLLEQSWLEMILKGTLKVSEITDDKLILVHVVHRIELNRINDVNVQLKTVDLLEKAVNAHLRLLDRQIRNRIGVEQMAARKTMPNQSNQSKKPEKHENGSASEPSKRRRTRPTGLNFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V252</accession>
    <name>A0A3P7V252_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000225">
        <property type="protein sequence ID" value="VDO26493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="82" mass="9328" checksum="57D344181CE121CD" modified="2026-01-28" version="1">MTNHLERIVDKGKRKGRGVRCKVLEGEKEKEKEDGKETVELERSCQPVVTPFSEILMSCVFAQNSVVDVLKRHDRSVAPCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V3W2</accession>
    <name>A0A3P7V3W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002833">
        <property type="protein sequence ID" value="VDO38389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800408at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="171" mass="19374" checksum="8FB4B44AAEAC726D" modified="2026-01-28" version="1">MNPFPPSARLPASSRFWFEPDDLKMPLNPDHDKIYGDKLMVRVSSVSHPDNFNKNNGNVPESRVISNPARYYLHGANFEKIKTLPCRLTSCHGPYPNDGSLLIKEEKNTSNEECEQIFVQMNGCVAHKGYPIGMVCTICCQCTEQFISEMSHSRGFLAKTDWLTTEKLAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VTB8</accession>
    <name>A0A3P7VTB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005962">
        <property type="protein sequence ID" value="VDO46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HFS1"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="101" mass="11548" checksum="12DB06E4B87CDFF7" modified="2026-01-28" version="1">MLRVFRSRGIIQLFCSQQRFCRTGKSVVSGKEIDIEVQKKTPRGKLDHELEMEEKEKPYEDPYLPKHPGGVNPITGEIGGPAGLEPTRYGDWERKGRCVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WE20</accession>
    <name>A0A3P7WE20_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLCG1 EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011116">
        <property type="protein sequence ID" value="VDO59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WE20"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PLCG1 EF-hand" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="138" mass="16524" checksum="7A222908D62B5FC6" modified="2019-02-13" version="1">MQNKKITYIVYNTGFIVNFNFIAFQGTSKTLRLDLRIVKEVHTLDFKLKKIKIGDKWEKDKEIKQYDASKILVLSYATSFNLRNWILLFDTEDLCRMWYQGVHYLMLDTISACHALLVERWLRKEFYNIAGYALENPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WY42</accession>
    <name>A0A3P7WY42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008079">
        <property type="protein sequence ID" value="VDO51917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WY42"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="174" mass="19681" checksum="CA9829B391BAD645" modified="2019-02-13" version="1">MQLTYHIQCINNKHGPNCDLNCTPVSSNKLHAACRSGITGMYHSCKYARDLVKVFDCTPCPYGLTANQTECDAPNIIPIIYENISPAFRIWTIVLGCLLGIAVIFIILLIIIFTIVQKREETSMPKRHNVRPSKTLLPWKHDEWQRSKTKATARDSGVSSRTVTSEEQIEVNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X496</accession>
    <name>A0A3P7X496_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013940">
        <property type="protein sequence ID" value="VDO68590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X496"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="309" mass="34856" checksum="19D7D25FF9641B6F" modified="2019-02-13" version="1">MNNEIIDIVEYFQKNPLKATDDIFTNDAETSSTFRNKLDNILSNKIMSNAINGMEKRQEKEIREERTKKDESSAVLPSLAKLRTKGPPRRSPSHLLQHSNKRDDNDEVKSISTSVVMNASAENNSIVGEKVELHKERQDSQLKIDLAKHITDNVNNIKHRSDISSIFSSDSDDDIFSTFSNKPKTSAPVSKSQVKNVNVQSLSSSREHPSITSESRTQAPKFDFKLKNLFDSDDEDIFASSISVKKPEQESIRNKEAILEKVIHETVIPKKDGSVLEKEETVVPRRKLNTAKPKRVDIFGDDSDGDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YBK2</accession>
    <name>A0A3P7YBK2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015716">
        <property type="protein sequence ID" value="VDO74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YBK2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12389" checksum="CB52452602C89C37" modified="2019-02-13" version="1">MQDLQRDLQKCRDNDETRLDLSSSDIVSIPSSIRDLVQLTELFLYKNKLAVLPNEIGNLVNLKKLGLSENGLTSLPDTLAALTRLETLDLRHNKLCEVDYLFFRKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BMG0</accession>
    <name>A0A3P8BMG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042459">
        <property type="protein sequence ID" value="VDP22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BMG0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="183" mass="19095" checksum="D8FB299199D1AB76" modified="2019-02-13" version="1">MQNYILIQKTVLANDATKHASEDVKNIGSAGEGSRGENEKSEDGNYPGVASPTVANNDEATANVQISATQISNNTTITDGAGGSTTNSAPLAKFENLETALTTTLGTHGYCPTVPHVINSTQPNCRTNNVANIDTQQAGLTQVSSLDAIHMSQQPCITMPEACETTQRSTSELAAMEVPKGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FAB1</accession>
    <name>A0A3P8FAB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041259">
        <property type="protein sequence ID" value="VDP19083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I520"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="123" mass="13873" checksum="407E193B637F61AD" modified="2026-01-28" version="1">MAPQTASAKRLTNENKTIKGVEHVAIFSEVAMRHNVGVLEYSRTCQAAAAGMASGILGLTGISGFIFYFVFVVLQALFWEMKANFEWQNYFISRSLSLTHSLISGLFTYILFWVFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXY0</accession>
    <name>A0A183GXY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS90</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000021">
        <property type="protein sequence ID" value="VDO24498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXY0"/>
    <dbReference type="WBParaSite" id="OFLC_0000008901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000008901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000008901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000008901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11044" checksum="ED80918EA1CF242E" modified="2016-09-07" version="1">MLSNHFAKVPVVDGVVALELVNGRCGGTSSINIVGGPMQQPVALLKFVLLSKENDVFVVWGGAEENIALIGLQMINWFEKLSRVWERQIPVYMDLNRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYB2</accession>
    <name>A0A183GYB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS222</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000062">
        <property type="protein sequence ID" value="VDO25046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYB2"/>
    <dbReference type="STRING" id="387005.A0A183GYB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000022101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000022101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000022101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000022101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62226" checksum="6979988E3D0127DC" modified="2016-09-07" version="1">MDTSEFRKFGKEVVDYIADYIENIQKRRVVPSIEPGYLRDLLPGVAPQHAESFKDVINDFDKYIMPGVTHWQHPRFHAYFPAGNAFPNILADMLSDAIGAVGFSWAACPAMTELEMIMLDWLGRMIGLPEAFLPFTENGKGGGVIQGSASECNFVSLLAARFEVLKELRQRFPFVEEGLLLSKLVAYCSKEAHSSVEKACMIGMVKLKILDTDSKFRLRGETLRLAIEEDRDLGLIPFFVSTTLGTTSCCSFDVLSEIGPVCQKNDLWLHVDGAYGGSAMICPEFRPLMDGIEYAMSFNTNPNKFMLINFDCSTMWVKDRYKLTQALVVDPLYLQHSWTDKAMDYRHWSIPLSRRFRSLKLWFVIRVYGVEGLQNYIRKHCRLAKLFEQLIRADDIFEIVGDVILGLVCFRMIASEEMNQALLTKLNSSGRIHMVPASLNGRFVIRFCVCAEHATEKDIRIAYELISQTARHIHHQEDLDKSEILKRKNQATLSQKRSFLVRMVSDPKCYNPKIVRHLTKSGFRKMNEDVVRDLSLRLFICSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYD3</accession>
    <name>A0A183GYD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS243</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000070">
        <property type="protein sequence ID" value="VDO25115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYD3"/>
    <dbReference type="STRING" id="387005.A0A183GYD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000024201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000024201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000024201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO25115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000024201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41804" checksum="8DD654DE4A79CF8F" modified="2016-09-07" version="1">MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEALFQPSFLGMESAGIHESTYNSIMKCDIDIRKDLYANIVLSGGTTMYPGIADRMQKEVTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H191</accession>
    <name>A0A183H191_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1251</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000561">
        <property type="protein sequence ID" value="VDO28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H191"/>
    <dbReference type="STRING" id="387005.A0A183H191"/>
    <dbReference type="WBParaSite" id="OFLC_0000125001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000125001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000125001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552339" evidence="1">
        <location>
            <begin position="22"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000125001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="56456" checksum="0426A2D57D09F215" modified="2016-09-07" version="1">MYRQLTGEFTLLSVVVCLVHSRVEKEKKKNITLMKFIPILKNSIEVILTTEYISRYCPNSQLPEIDAIGTIKHCLPGHEGLCGPGYSCYFSGTNYQCCPTQEEIDLDTILECPSPGITILTDAGLPLICIRGLHDCPQSSMQCLNVGKHSVCCEGSSSITEEPYDALSLKELNSPDEIIQPIALSNELLNIPNLECPEPAFTILNGNGDPLSCNEEDCAHQPGRFCYKILNTPICCEGEERAIDDDTMIKKILQEKHEKEGDVTWSTLKYTPITIAQHQLQQNQPSQNDSRLGTDVSSVARSPILESDSETKQTNLEVTKSTDSLANHFGEKQIDNQHGNSQQSIIPNNADTSNAITISSTTTPSISSTFSTTTSSTFLTTTSSTTTTRTTITTVTPTVITSTTSAFRALGKPNKLIFLQKKIQYQSLTPPSGESREDGNVMNRYKPHNAGGYAVSQAFSSKIRRAPNDLRALAREYLLEHIRRGWPYSDEFYRTYSEFYTIQISKNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1L5</accession>
    <name>A0A183H1L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000633">
        <property type="protein sequence ID" value="VDO29300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1L5"/>
    <dbReference type="STRING" id="387005.A0A183H1L5"/>
    <dbReference type="WBParaSite" id="OFLC_0000137401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000137401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000137401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000137401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16002" checksum="D2E0AF9AAA818306" modified="2016-09-07" version="1">MTFLLYSDILSACFVVQFYCPVLTQYSNLLDLFGINTGRSGMVSGRIPIDDITSQSFALISFIQGLQKNPNKQFNKRYHWQFWGAGGCLPRPMPLTSQHSPSLFQNLLRFIPGVQDYLSDLVKTPVISTAGVHDRYCPTTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1S8</accession>
    <name>A0A183H1S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000677">
        <property type="protein sequence ID" value="VDO29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1S8"/>
    <dbReference type="STRING" id="387005.A0A183H1S8"/>
    <dbReference type="WBParaSite" id="OFLC_0000143701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000143701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000143701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000143701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10247" checksum="EF73F2DD01F346C1" modified="2016-09-07" version="1">MIMLAAIHPYSKNNSSSSSTSDADKHTIKITDVTDQYLEEKDDEMQEGSLIEYCRINHQENAKRQPQICIADKIIKITPLEYENFNKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V5</accession>
    <name>A0A183H1V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytoskeleton-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1465</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000695">
        <property type="protein sequence ID" value="VDO29637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V5"/>
    <dbReference type="STRING" id="387005.A0A183H1V5"/>
    <dbReference type="WBParaSite" id="OFLC_0000146401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000146401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000146401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="286"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="459"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="639"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="538"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="900"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO29637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000146401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="976" mass="108924" checksum="F5E553690AB58C0E" modified="2016-09-07" version="1">MAFSRNQWVSVDVLAKLPEQFNEWLESKKWTERRDALQSLVNEIAKTPRLDPRVDYFNITQSLRNVLAKDANINVCALAAKCITGLANGLRTKFAQFATLYISVIFERFKEKKSTLRDPLIECIDAIALTVNLDMLVDELSGCFNKPNPQIKLQGCNFIYRVMKNHSQTSAPKKTIKAITPILVKFTADPDAEVREAACIGLGSIMRLTGDKVMNTFLGNLQEDKAKMKKICDGRDQATTEYNEEVKRKKESIPCENDAVPSVDAVANGSTAAGTESVAQEIDPWDMLDPVDVLAKLPGNFMEDIDSKKWQERRDALQSLLVLCHENPKLCPKANYGEFVAFLKKILEKDANINVCAVATRCLTAFATGLRKKFAQYATLVAPTIFEKFKEKKPVLRDPLIDCIDAVAASTTMEALAEDIQTALNKQNPHIKIQTNLFLYRVFKRHNPQTVSKKVLKLLAPIIVKLTGDSDPEVRDASYAALGAAMKAVGEKLCMALLADIAEDKMKMAKIRDFYEKAVQEAGTDVVSIMVQSMHKSNLENGTGVGNANSNSTSPLKPPAPGVGNSNVSGKTSSKEAMEEDNTEEKSSKTPKKEFEAVKEPEESMKSKDEFLVINKDKGARLKDERNLRVLKWNFDQPDIEHVEQLKTLLGNITQASLLTFLFNKDFKQQVKGIDILQSLVTDCPESLVSNSDLLLKWISLRFFETNPTVLMKVLDLTQGIFNLLLQYNEPFSDQEMFSFVPYLLLKLGEPKDSVRTPVRTIIQLVTELVSPPKIFPLIIEGLKTKNSRQRTECLQVLEQLLDTTGMAATTTPAQSLKQIAACIDDRDNNVRNAAINAIVVAWKEEGDRVFQLIGKMNDKSKAMLDERIKRSGVVSKARGGPERIGTSARRNANISVGIKGRGFRSDRSSSRMGRNNHRNHSVSRDSSPAEERENNRTFTMQKGDTGDPSDDNDGTRKRFALNLDASYLMIVSYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H337</accession>
    <name>A0A183H337_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP8_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1897</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000998">
        <property type="protein sequence ID" value="VDO31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H337"/>
    <dbReference type="STRING" id="387005.A0A183H337"/>
    <dbReference type="WBParaSite" id="OFLC_0000189601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000189601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000189601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000189601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53665" checksum="702D86319B765473" modified="2016-09-07" version="1">MVLNRPIINRLADLRFSSLEHLKSWCDATHKQKWEHTISRLVCIKAFDHAERVFDEAKLKMQEGDEEDAYKLFTRMGIISKIIISKSDFQEFKNSPDGRRFYCLFDQCIAYLNELEESLNKRYELKKVEKSYDERNSSVVQREETRKDKDYFMDESMVIDPRDLVRYVTCKHRALIIDYRNDQRDVIQYANAEQLLVAQVPVDAIVPGCIGSSLIRSAEIGQRAILQRMADVDMVVLMGSENIPNEEKDMIAGSKEQILYSALSMYNNNFRLKKLPKFLKGGFENWRLYYPMHTSTKSAMRKKFVDIANRTEFARAVADYKKGFGIDSLEYPQLLPAIYSKTSGSSMPHSSISDSVVNQMGQSSFCSPVLMESANNSDTSSPSSLSRTLLPKDKSFDVRTDATSTANESSIISDSNIMEAANCGNTNQNSNSQIDVPALQSHQPPIIDRSKKPLSEVCIKYIIIMKKMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H498</accession>
    <name>A0A183H498_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2308</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001298">
        <property type="protein sequence ID" value="VDO32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H498"/>
    <dbReference type="STRING" id="387005.A0A183H498"/>
    <dbReference type="WBParaSite" id="OFLC_0000230701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000230701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000230701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552369" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000230701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10206" checksum="7A8B8AA1EC08F138" modified="2016-09-07" version="1">MIGGFFFVLLSPLVLLVQIYTLEKIRNHSTMMQTASNQSKSEASCKDIRNLSEAGAEIDEQNDSENMALLLAVKNGRTIVKDCSRMELIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Q7</accession>
    <name>A0A183H4Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001424">
        <property type="protein sequence ID" value="VDO33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Q7"/>
    <dbReference type="STRING" id="387005.A0A183H4Q7"/>
    <dbReference type="WBParaSite" id="OFLC_0000246601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000246601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000246601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000246601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10610" checksum="CF1F682C6A50E911" modified="2016-09-07" version="1">MEIIKDDNTLEPKAHPYPKMTQFSDNLENNEGIMKDTWSMNKTYDMLQEIFDREEHERRTQAKSVLTGIPAMNEETWMIFRNDLTKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5W1</accession>
    <name>A0A183H5W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2872</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001765">
        <property type="protein sequence ID" value="VDO34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5W1"/>
    <dbReference type="WBParaSite" id="OFLC_0000287101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000287101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000287101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000287101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6249" checksum="79B8CA667DC4ABB0" modified="2016-09-07" version="1">MSCQMESSHCGSILENNVSGCRIATDDCCIESALLDGYYKLSDSAKQIPSAYNGNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H692</accession>
    <name>A0A183H692_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001880">
        <property type="protein sequence ID" value="VDO34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H692"/>
    <dbReference type="STRING" id="387005.A0A183H692"/>
    <dbReference type="WBParaSite" id="OFLC_0000300201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000300201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000300201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001055">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000300201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20988" checksum="3E3025914604B292" modified="2016-09-07" version="1">MSLREAGSTRLKQLEQCYLNVSRSEDVLSIESLIDALICLFDECCSSTLRKEKNIADFVEYVKPVVVKAKALRLCREDFEVLKVIGRGAFGEVAVVRMRNTERVRRMVYNQAFLESIFHLEGNFSFFFNRIILINMDKFGHFLVVYLKSAEFIFKICVLLDKINSVIELKENFDYKFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Y3</accession>
    <name>A0A183H6Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3242</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002108">
        <property type="protein sequence ID" value="VDO35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Y3"/>
    <dbReference type="STRING" id="387005.A0A183H6Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000324401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000324401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000324401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000324401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33355" checksum="93A80F788E777DF6" modified="2016-09-07" version="1">MTFLIEMALLKAFQKQSEKKPCPVCGHLVTRGLYRSHLNDCKLQPDDDDCQIIAEVRAKDRKREATESLNSSDSSDDLFDNSDQVADEPDSKSKDSESLLPDVVNDNENSADANEWKQMTAGVVKKKMTEEIPTEAVDRIHDSLVRKRTKKVFLSESEKMVEVVQKVDSHLLMLTENKNKISRPSKAVISRAPEKCSENERMQENQEEIKFCFRNFFHTEAMTSHEIKPEESLLSILENIKSYLDVCECSLVRNSQILPNHEYSAIEATQIGSPYYLTLFHKIMKRVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H717</accession>
    <name>A0A183H717_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLVR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002145">
        <property type="protein sequence ID" value="VDO35950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H717"/>
    <dbReference type="STRING" id="387005.A0A183H717"/>
    <dbReference type="WBParaSite" id="OFLC_0000327801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000327801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000327801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000327801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59870" checksum="D5334A742DECCFDC" modified="2016-09-07" version="1">MEYIGVSLNNIIDTVRDAKVENSESSEESDEDDGERKSKKKAIKRLGVHPQKPIVPIALSRSRRHVAKVDYKFGAYDELIQEAVKNIDESAARQMNRTNVRPKGGAGRGKDMANIINAENKRIPISMENTQEDDGFDGHKTIRMQSKIGKPTKNRHRLNDLNVDEMTESDTDEYQASDSASVSDPSDDTDEYLPSDASYTRRASKRNYYSNKRTQSDDDFVVSGSESEYEPSRKKSHRSKNTRKIKGKRKREKWISSDEDSISELSDNYQSEESNSSGDRRARRRTVTKWGPRASSSDAEDSSHSVQKTAAGRPLRKAVAKRPSLTVDNDGDEEEEEDEEEIEEKLKNVRPVGTGRKIESSDEFEPDEEEDEVDDEEEGVEDEEMEDNEETSTIDDEKQEQSDEEESVEEKKRKILKAENDIKDMKEITFSSTKTSFIDDDKKQTEDTDDVYPSTSNDAKLMDETAEKVKSKQIDQEIFYTESAKTEDIKKEMKMSEKMVVANMTATNSNVTSCVPPSWYMPISCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8I0</accession>
    <name>A0A183H8I0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3794</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002655">
        <property type="protein sequence ID" value="VDO37770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8I0"/>
    <dbReference type="STRING" id="387005.A0A183H8I0"/>
    <dbReference type="WBParaSite" id="OFLC_0000379101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000379101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000379101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000379101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5530" checksum="CA81CE91BA00543D" modified="2016-09-07" version="1">MQYGEPPIHVLNECYSTADLGVSVGIHQQALMKQYHQFENGPFADFSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8X8</accession>
    <name>A0A183H8X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3939</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002811">
        <property type="protein sequence ID" value="VDO38302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8X8"/>
    <dbReference type="STRING" id="387005.A0A183H8X8"/>
    <dbReference type="WBParaSite" id="OFLC_0000393901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000393901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000393901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552435" evidence="2">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000393901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20887" checksum="7E25BABB6AC1371B" modified="2016-09-07" version="1">MLSFLSLFLLIISQNGHIFASYCGEDAIPFSLQTLRSGQPVLGCARPSCFGWGAKTDKGARFYRINKKSDGFMRDSDHKKYDKVKIVARESQLAVLQFQVCEKNYSSLSCDENTQWVGGLSPSSNITATPLRLQCCTFGKLKNSWDRGIADVGPGQIVIGGEVMQGERQYAFDYIANIKKYFKENGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Z7</accession>
    <name>A0A183H8Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LINES_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002831">
        <property type="protein sequence ID" value="VDO38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Z7"/>
    <dbReference type="STRING" id="387005.A0A183H8Z7"/>
    <dbReference type="WBParaSite" id="OFLC_0000395801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000395801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000395801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000395801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41362" checksum="EBE153DA5D276310" modified="2016-09-07" version="1">MDEGKALGVLDELSRVNIDNPDLKSVLESKILFDRSFYSLPDCTVRRRFFSVVECFLISLWQKSCFGCKHLDEETVYVVSVFGILKDVVLEICFNAETVWFGGEQSGLKTNPLNNAIAFLSCCWHAAALAINICDAWEIQDLLKASVRMIPLCSCLSTALLTQDERCLSVAVALLHLETAKIHTPPQLSAMWLFRHILFSVSYDYKVVLDWLHSELAAVPFVLRFLKMLINQQKDVDEQQYSSFSCLQCCERNKKTRFVRNKKVFPGNELTLCIRQLHGDLPVATSYTFSKIEREVCLMMPKSSEKESGDQQIVKCFENLRTSCIRLQNSGDAPFNVTPIMRLVEQLQKTILEDEIASASKCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H931</accession>
    <name>A0A183H931_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3993</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002871">
        <property type="protein sequence ID" value="VDO38520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H931"/>
    <dbReference type="STRING" id="387005.A0A183H931"/>
    <dbReference type="WBParaSite" id="OFLC_0000399201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000399201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000399201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000399201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27186" checksum="05185805C3575149" modified="2016-09-07" version="1">MVKKLREGSVSQPVRQSHRIRILNTRLGTPPKILLDMLRDHSSSAVKKSLPAVTDVERIGLNCGALISINGSKQKLNTSSFSENVSQNTSRILKTVKKTAAFTSNESKKAKVLRNSKNEKKHILSKPLNNVLSKNRHSSRIRIPNSRFDYLLPGFLEQSGNGKRRDNMEKSSRNREVDKLPLISEEEKIIANSPKIMYDKSDIPIRLRHSERQRIPNKRLNFPDIYPDIQAQKKSNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H995</accession>
    <name>A0A183H995_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4057</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002938">
        <property type="protein sequence ID" value="VDO38727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H995"/>
    <dbReference type="STRING" id="387005.A0A183H995"/>
    <dbReference type="WBParaSite" id="OFLC_0000405601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000405601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000405601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000405601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="69286" checksum="87CA4A456B37721F" modified="2016-09-07" version="1">MVKGLEEAVEAIETAFEEEKKEKEKEMLLGLEERAAASGKWTISGKDIKKEGQPISIGTENVRNESTQEVGYKGLRLKDCLEYYRNNIARETVGTQPVSLLYDTQKSHPADISSISRRNEKSSNYAIPISGTTQLSENRDSVPLRSHFAHVSNQSILNTSLSTIATEIPQQYMLANSIALPPHSLQVSRPSGAHPQVTIVSSALQQTVTSPYHFSVNQRTSPSQNHNIIANTQQIDTILPAPISLTQDISQTVSATTTTGSIIGQLMTTPQNITTSPRLSVPIFSNYRNISCASIPALSEQLALTPRSGPGLNTITAIDVQKSVDGTVLHPQVYDSPFAPNKMHSNFARSIIPTSTISTLVKPAVIPAHHLIYSQDATTFQTTMSPWHQPLRNGVNNLSGPVVVGSTRMACTIEPTTGFQSFVPNNQAAPARTTPVMDIMNAPLDVVLPVPLTPTHLANEIKSSNSSVEVITVHSSSAESTRMEEMNLGQMPQLLESAGTSSGNSTAVQTPRPAAAVAPIMQTDFNTTSAYDSTLCITNVTSMSYSPMLQPKTAPICTWQHTEKENISRNEEGYNSNVKEIMDPQTFTIGNTDPVRLEKRNMREQFKTQGIGAHLPPLDPTDPINCIDAHYWLNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Y1</accession>
    <name>A0A183H9Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-terminal acetyltransferase B complex subunit MDM20 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4291</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003195">
        <property type="protein sequence ID" value="VDO39536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Y1"/>
    <dbReference type="STRING" id="387005.A0A183H9Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0000429201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000429201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000429201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO39536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000429201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="21230" checksum="A0116F12B57C7216" modified="2016-09-07" version="1">MDSELDEIEIIFAQKLASGEPITRRRAFRTLCDWIQSESAKQEFDDKAMLHLTKGLHYVMWMQDKMLWQEHLADNIASLLNLFEREDESVLFVKCMLMTISNEWPRIDRWRMDKFLMLIRRLVRALFLRLRSKNWKKGITDMYMKAFKDCVISNDKSFSEALKFHFASIYLDEMDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA65</accession>
    <name>A0A183HA65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rubrerythrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4377</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003292">
        <property type="protein sequence ID" value="VDO39797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA65"/>
    <dbReference type="STRING" id="387005.A0A183HA65"/>
    <dbReference type="WBParaSite" id="OFLC_0000437601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000437601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000437601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000437601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="15115" checksum="B840421076374491" modified="2016-09-07" version="1">MESKKEEKEEKEGITRSTRLQEEKARLEEARLLREEQMELRKKQEFYHGFADKAQLERHEQITQQLEQLAETERQHREQLEREERIRLASTKHYRTTLSDDSFSTTPISITTLLESNDQVIIIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAD7</accession>
    <name>A0A183HAD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4449</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003385">
        <property type="protein sequence ID" value="VDO40046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAD7"/>
    <dbReference type="STRING" id="387005.A0A183HAD7"/>
    <dbReference type="WBParaSite" id="OFLC_0000444801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000444801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000444801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000503">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000444801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36744" checksum="5C7E18B306F6FF98" modified="2016-09-07" version="1">MTSVPPKITDPAFRTIESVLNQTVNIECKGTGIPTPKIIWSFNGRTIFPSEKIQILNDDTLLILKEVQINQEGRYSCTATNKVGKAEADIFLQVIAPPRILTSIDELKVIEGQGQTIRCEVSGTPVPKVEWFKNGQQFNATVAQSSSDLHYIYLREAQVSDAGRYTCIARNRAGEHRMTIQLYVLGEKFLQMIVNNLSVPPTIVEGERIVQVKENASLTLECVATGNPKPMIVWKRDGRPLETRGSRFVITSSKVSDGGRYTCEARNEAGKTSTDFEVDIFIKPRFRDLKTEIRVRDGERARLECKVDGHPEPTITYDFFFFFFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW0</accession>
    <name>A0A183HAW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SLC12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4622</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003602">
        <property type="protein sequence ID" value="VDO40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW0"/>
    <dbReference type="STRING" id="387005.A0A183HAW0"/>
    <dbReference type="WBParaSite" id="OFLC_0000462101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6487" checksum="0E321496C56CDABA" modified="2016-09-07" version="1">MNDLIKRNSGDAAVCLLNLPTPPKDVSYSEQYLEVIRHLTDGLPPTLLVHGLSSVISTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBQ9</accession>
    <name>A0A183HBQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ThiF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4921</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003985">
        <property type="protein sequence ID" value="VDO41449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBQ9"/>
    <dbReference type="STRING" id="387005.A0A183HBQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000492001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000492001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000492001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000492001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45180" checksum="2D22AFAA67AFD902" modified="2016-09-07" version="1">MQDDPRYDRQVRLWGDEGQSCIEHASVCVLGASALGCEIIKSLVLAGIKSVYIVDSAVICKPDLGNNFFVDDEIGQPRAKVALRLLMELNPSVEGGFDLGSPEDFITKDMDFLRQFTVVVGCNLSIDVAAQINDFLFEKNIPFVHARAYGLVGFIRVSVQEHTIIDTHEENIAPDLRLDCPFPALTELVESIDLNQMHYDAHSHTPYLILFLKALALWREKYGQDDFPDNHEKRKAFEMIFMSLRMPHPENESVEEENFIEGRTAMIGSLKRTTIPRGVKELLDHPKATYPDLARFWLLAAALRRFVITHKVLPVRGSLPDMISDSESYVLLATKFRDKAKQDAKEVMNYLQAFLMERGVPIDIIKFHDCEFFCKKAAFLRVQHGTTIAQEMKSSLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBZ0</accession>
    <name>A0A183HBZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004088">
        <property type="protein sequence ID" value="VDO41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBZ0"/>
    <dbReference type="STRING" id="387005.A0A183HBZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000500101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000500101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000500101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000500101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12680" checksum="77D491904BBEAC91" modified="2016-09-07" version="1">MWYLGVFPEYIFSQSPITNSARIEGAACAPERSELEVMATVKCNGDAIHHSDEEVDLSCSSPETKIDSLVSNHPLKYVWTYWYLNDQRDKSWEKRLKVVSNFGTVEEFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBZ3</accession>
    <name>A0A183HBZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5004</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004093">
        <property type="protein sequence ID" value="VDO41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBZ3"/>
    <dbReference type="STRING" id="387005.A0A183HBZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000500401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000500401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000500401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="150"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000500401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33305" checksum="ED216CD501BF2F0D" modified="2016-09-07" version="1">DLSFSVHVAECSTSELLFCVPGINVNGLTENDIHSFPQDNPHFANDSLADLLESADISNSPSSSKLIGDDSEGIKEPYNESEIDVEQLVITVDDVEPSSSGKDELQAQDREYSHAHVLNTSNNVADYEILKNNMARQYPFQLDPFQQQAVICLDRGDSVFVAAHTSAGKTVVAEYAVALCNLHKTRAIYTSPIKALSNQKFREFKLIFEDVGLITGDIQLHPEAFCLVMTTEVLRSMLYNGSEIIRELEWVIFDEVHYINDAERGHVWEEVLIMLPAHAKIVMLSATVPNCVEFADWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD28</accession>
    <name>A0A183HD28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Animal hem peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5390</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004604">
        <property type="protein sequence ID" value="VDO42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD28"/>
    <dbReference type="STRING" id="387005.A0A183HD28"/>
    <dbReference type="WBParaSite" id="OFLC_0000538901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000538901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000538901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF58">
        <property type="entry name" value="PEROXIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000538901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35622" checksum="0426719231A156F0" modified="2016-09-07" version="1">MSMHTIFMREHNRLAIQIASLNPDLDGETIFHETRKIVGAELQHITFYYWLPKVLGKKQFDKLIGPYKGYQPLIDASISNAFATAAFRFGHTLVNPILYRLDEKLAPIMQGHIPLRDAFFAPEVLLSTGSIDPYLRGLFATPMKKPISNELLNDELTENLFNRAHEVSLDLAAINIQRGRDHALPGYIEFRRWCNLSAVENWDDLKNIMPNEVIYKLKDLYGHPGNIDLFAGGIAEERLDEALVGPTFSCIIAEQFRRIRDGDRFWYEKEDVFNEAQRKEIKKASLARIICDNADNITTIQVSTTYYANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDK9</accession>
    <name>A0A183HDK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5574</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004856">
        <property type="protein sequence ID" value="VDO43597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDK9"/>
    <dbReference type="STRING" id="387005.A0A183HDK9"/>
    <dbReference type="WBParaSite" id="OFLC_0000557001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000557001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000557001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000557001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15082" checksum="BD5BFD1CD4FC7CEF" modified="2016-09-07" version="1">MLCLKERVESVVDYAGLNIHEPADLYLLVTLQVATRVVQSKKLSIGINRESAETLFMECDGTILDDNQRTQRIQLRMSLWHDVVPGFNSYFQGQIRITLDDNIVQKESAGPQWFVLHLFSLNNFFYYEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDY1</accession>
    <name>A0A183HDY1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calsequestrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5692</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the calsequestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005031">
        <property type="protein sequence ID" value="VDO43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDY1"/>
    <dbReference type="STRING" id="387005.A0A183HDY1"/>
    <dbReference type="WBParaSite" id="OFLC_0000569201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000569201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000569201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051279">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001393">
        <property type="entry name" value="Calsequestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033:SF0">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01216">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00312">
        <property type="entry name" value="CALSEQUESTRN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552490" description="Calsequestrin" evidence="7">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000569201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21773" checksum="13C2FB182BBC14C1" modified="2016-09-07" version="1">MWLVVTTLLLLSFISRSGQVTTAKTLDINCMFLGYPELEYDGFDRTEVLNEKNFNKTVLTGDARTIVFFNDVEEDDPELDQYECFLQLSAQIMTKRGYSFYTVNTTKETRLRKQENVQRGEDTIHVYKDGYKIEYFGVRDPETFVSWLMDIPDDPVTIINDEHDQNGFEALEDDIVRVIGYFEPGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGH5</accession>
    <name>A0A183HGH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6588</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006349">
        <property type="protein sequence ID" value="VDO47017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGH5"/>
    <dbReference type="STRING" id="387005.A0A183HGH5"/>
    <dbReference type="WBParaSite" id="OFLC_0000658601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000658601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000658601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000001">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO47017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000658601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="30242" checksum="05FCFAEEEFF409AB" modified="2016-09-07" version="1">MEHGGPDRMLKHNTNQIEFNVNVLTMGHWPTYEYMEVAIPPTLAEYQEHFQNFYFSKHNGRKLQWQHSLAQLLLRAQFNVVKELQVTMFQALVLLLFNDKLEWTYEEIQSATKIEKNELERTMQSLACGKLRVLKKVPRGKDIDVNDLFIFNPECNEKLYRIRISQVQLKETAVERAQTEEEIFQDRQYQIDAAIVRIMKTRKSLPHQLLISELFNQLRFPVKPVDLKKRIESLIEREYMCRDKDDSNVYSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHA8</accession>
    <name>A0A183HHA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IGFBP N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006797">
        <property type="protein sequence ID" value="VDO48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHA8"/>
    <dbReference type="STRING" id="387005.A0A183HHA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000686901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000686901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000686901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552540" evidence="1">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000686901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15001" checksum="6B48736DA201DBFB" modified="2016-09-07" version="1">MISTTRWKRQICCCCPVVLTCCAAVPAPVVHPIPIFRPVPVIGPIPFPLPVPNLQPFPAPHPLLPVTRPLPIPVPLPIFQPFPSHRPFGIPCCVCCMPVCVQKCLSHCTTIGCDVIGRKKRAIAMNKYYVSNGPFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHB0</accession>
    <name>A0A183HHB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6872</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006804">
        <property type="protein sequence ID" value="VDO48197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHB0"/>
    <dbReference type="STRING" id="387005.A0A183HHB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000687101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000687101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000687101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000687101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8802" checksum="D6CB1CB241E1EA8F" modified="2016-09-07" version="1">MRFFKTAVDMMCLIHSKIVIDADKTPTGKYVRRFNAPTIDDVAVVIVGYQSNLEILLLWKNDQLTKIGETHQCYNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHR7</accession>
    <name>A0A183HHR7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS7029</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01007074">
        <property type="protein sequence ID" value="VDO48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHR7"/>
    <dbReference type="STRING" id="387005.A0A183HHR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000702801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000702801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000702801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000702801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12155" checksum="10CCA1A505016B7D" modified="2016-09-07" version="1">MSRLEREYDVLEEIGRGGFGVVYRARCIAKGKEWSGKNIDIIRATRFRVELELEALSKLIHDNIVKFYDQFQEDGAQYIIMEYCKHRSLRDYVKQNGKLSDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI19</accession>
    <name>A0A183HI19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007235">
        <property type="protein sequence ID" value="VDO49473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI19"/>
    <dbReference type="WBParaSite" id="OFLC_0000713001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000713001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000713001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000713001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20915" checksum="A922AFC01444D71C" modified="2016-09-07" version="1">MSRRNIREGKFDVLRGIHNNLTEAIRVANETLAKIERQERNFYKTYKRPENDFLNDFISMSKEREGIISQQFMKRFDRLISDVNVRLKILEAKINVLPKSHSSQATVAYKNTSGVGRFSTLKVVDENPSSDASSSTIDLSSIKQGDSAQLAKIDMELMQLEENVSKIEMRIQEDAEAEEIGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIB4</accession>
    <name>A0A183HIB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HECT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7225</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007402">
        <property type="protein sequence ID" value="VDO49899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIB4"/>
    <dbReference type="STRING" id="387005.A0A183HIB4"/>
    <dbReference type="WBParaSite" id="OFLC_0000722501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000722501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000722501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO49899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000722501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6225" checksum="852902FDDCD87424" modified="2016-09-07" version="1">MSAVKMRIQPCDDKAIPVAHTCFNLLDLPNITDREEMRRRILICLDNSHGFNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIV7</accession>
    <name>A0A183HIV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007738">
        <property type="protein sequence ID" value="VDO50905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIV7"/>
    <dbReference type="STRING" id="387005.A0A183HIV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000741801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000741801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000741801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000741801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11111" checksum="7D568ED196872ABF" modified="2016-09-07" version="1">MKSEKELFFEILRRKTHIFCDVKENATVLELKKIVEGILKVPINKQILKKQNEDGYWQTIEDRQTLSECGYTPQNSRAQAPAPLALVFANGKHRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIX4</accession>
    <name>A0A183HIX4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2">1.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7438</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01007774">
        <property type="protein sequence ID" value="VDO51009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIX4"/>
    <dbReference type="STRING" id="387005.A0A183HIX4"/>
    <dbReference type="WBParaSite" id="OFLC_0000743501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000743501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000743501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase dimerisation" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO51009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000743501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21726" checksum="C2ED2B4E9A5EAFE7" modified="2016-09-07" version="1">MIEAWRAQHSEHRTPTKGGIRFAPDVCEDEVRALSALMTYKCSVSDVPFGGAKGGVKIDPKKYTEYEIEKITRRVAIEFAKKGFLGPGVDVPAPDMGTGEREMGWIADTYAQTIGHLENDAAACVTGKPIVAGGIHGRTSATGRGVWNGLEVFLNNEEYTSKIGLTPGYEGKTFIVQVDFIFNLFIIYINLKCKCLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIY1</accession>
    <name>A0A183HIY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007786">
        <property type="protein sequence ID" value="VDO51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIY1"/>
    <dbReference type="STRING" id="387005.A0A183HIY1"/>
    <dbReference type="WBParaSite" id="OFLC_0000744201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000744201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000744201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000744201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="6262" checksum="6828F8E0CE22FB58" modified="2016-09-07" version="1">MHMLEKLTKIPVKRMRLFYINSFNLFPNELRFPSQMLQALHIEDGDRICVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJU6</accession>
    <name>A0A183HJU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7758</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008303">
        <property type="protein sequence ID" value="VDO52423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJU6"/>
    <dbReference type="WBParaSite" id="OFLC_0000775701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000775701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000775701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000775701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7818" checksum="7DECF2076CD53955" modified="2016-09-07" version="1">MRHRPSHLNGLHRTMSRNYHYNLCHKHIERRGHSRERKKSWRGKEEKETDITVIGKGGYDREHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK01</accession>
    <name>A0A183HK01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1947 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008402">
        <property type="protein sequence ID" value="VDO52624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK01"/>
    <dbReference type="STRING" id="387005.A0A183HK01"/>
    <dbReference type="WBParaSite" id="OFLC_0000781201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000781201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000781201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000781201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="22201" checksum="B56CE19D45ADC29B" modified="2016-09-07" version="1">MLLFISAATTVQMRTTILRYLLRLTAPSSAYFLVSRAYSNGKGKRGPEMFQLEHIRKRLEITAPRFFREQPDYTFYRPDVVYRDEIFQMTITGRDKLMIYFGSISVMCLFAFPHIEMEVLNILPISEDGTVRLRWRIKHVSLSRALLNPMLFKYEYRIKKLKWYDGLTIFYVGEDGLVYRVITRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK21</accession>
    <name>A0A183HK21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7832</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008427">
        <property type="protein sequence ID" value="VDO52717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK21"/>
    <dbReference type="WBParaSite" id="OFLC_0000783201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000783201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000783201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000783201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19124" checksum="71B542A855EF76EE" modified="2016-09-07" version="1">MTSKMRRKDGLLLDSDDSDIPDLDLPTANVRKERSGLFSKARQNSVIVRQQNCSIQTVLMLLLFAVVVAIVFLGFFTSYIWSQLQQLHNDPKHEVVTRELEIIKQELNRIKLDIDMLRMMTSSPGTSTWNASSLLYTRLEDIESQISDIADKIQVKSHFISPLIFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK43</accession>
    <name>A0A183HK43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS7856</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008482">
        <property type="protein sequence ID" value="VDO52858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK43"/>
    <dbReference type="STRING" id="387005.A0A183HK43"/>
    <dbReference type="WBParaSite" id="OFLC_0000785401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000785401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000785401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO52858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000785401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19272" checksum="40963B8D30554E87" modified="2016-09-07" version="1">MSYRLMTVVKPLIWMEAVVERHTHSRVEYMIKANGYHNAKSQFKRRSTANNVEIIIPVPSDADSPKFKTSIGTVKYTPEQNSFVWTIKSFPGGKEYLMRAHFNLPSVQSEDREGRPPMKVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK68</accession>
    <name>A0A183HK68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA_dh_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7882</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008531">
        <property type="protein sequence ID" value="VDO52979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK68"/>
    <dbReference type="STRING" id="387005.A0A183HK68"/>
    <dbReference type="WBParaSite" id="OFLC_0000787901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000787901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000787901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF38">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE 10, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000787901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16156" checksum="34B36FA67BB5FDCA" modified="2016-09-07" version="1">MGAFDITRPAVAAAATGLSWRALDEACKYALERKAFGVPIAMNQGISFILADMAANLELARLITYHAAVAVNNQAYYASIAKCFAADTANIAATNAVQIFGGNGFSKEYPVEKLMRDAKIYQIYEGTSQIQRIVISRHILQKIASSGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKZ6</accession>
    <name>A0A183HKZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009007">
        <property type="protein sequence ID" value="VDO54304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKZ6"/>
    <dbReference type="STRING" id="387005.A0A183HKZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000815701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000815701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000815701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000815701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17372" checksum="7AC40BD9E7D68455" modified="2016-09-07" version="1">MDRNKEPTPDLMPDTLSLLSSVMLAQAQEAIYIKAEKDKMKPLALTKLAAQCAEYYHEAQKQLQRDAVKGLFDKEWTNIIKGKALGLSALAQYHKAFDNADSKNIGEQLSRLTESHSLMQQANSYMPHGIFDIQHAAIEKAYASAKKDNDFIVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL69</accession>
    <name>A0A183HL69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009143">
        <property type="protein sequence ID" value="VDO54680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL69"/>
    <dbReference type="STRING" id="387005.A0A183HL69"/>
    <dbReference type="WBParaSite" id="OFLC_0000823001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000823001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000823001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF53">
        <property type="entry name" value="K+_CL-COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO54680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000823001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17192" checksum="4A8267465DC416B6" modified="2016-09-07" version="1">MLSRNLGTEFGTAIGMLFYLGNAVAASMYLVGGVEILLIYIFPDLTIGGREVQSQTDMFGMMSHNLRIYATLLLLLEFVVVAMGVRFVQLFAPISLFCVILSILSCFAGGIEKSISPENGQRVCKMGDHLLQAQVFMPENVSLMHICKYCNERHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLD2</accession>
    <name>A0A183HLD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein RFT1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009244">
        <property type="protein sequence ID" value="VDO54968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLD2"/>
    <dbReference type="WBParaSite" id="OFLC_0000829301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000829301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000829301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000829301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17442" checksum="C1A1EE0E5F3BD070" modified="2016-09-07" version="1">TSKICIFQVFFNYFVQFLLVYVCFISQLIFKVSAYSQTLWGEVQKEETTLNGFAEATYTACAAIAIMLMNILSIDWDKWGEIALVLISSVDCGLLLIFSQAQTINVMYICYICYRMLYQVMITIAQYAVNLFCQIKLNVLGLKLLIFHDSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMC0</accession>
    <name>A0A183HMC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nop domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8629</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009924">
        <property type="protein sequence ID" value="VDO56614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMC0"/>
    <dbReference type="STRING" id="387005.A0A183HMC0"/>
    <dbReference type="WBParaSite" id="OFLC_0000863101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000863101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000863101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO56614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000863101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21321" checksum="5876061AAE119B24" modified="2016-09-07" version="1">RYCSLPVECRICKLTLISAPQLARSLHNLLPLPVFEEVDTTEGMVKRTNNKEVKKSADQPTKLNPFELKYNRAKHKILGTKAVSAPCGAPGLSKKKAFENRARTLAVEWKERGKRNKIIDQRIGEGNGMVSNDEYISKRFTAERLKFFKAANSELANDGEEKLTHRGRELTEVGKYDRTILSDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN63</accession>
    <name>A0A183HN63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8925</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010491">
        <property type="protein sequence ID" value="VDO58047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN63"/>
    <dbReference type="STRING" id="387005.A0A183HN63"/>
    <dbReference type="WBParaSite" id="OFLC_0000892401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000892401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000892401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO58047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000892401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12025" checksum="D454E99AD5E85B16" modified="2016-09-07" version="1">MIVGETDLIIQGSKQSDNGRYTCFAENEAGVLNTNYELEIIAPPKFHRRSEGVYEVILGKTVTMDCDVEAEPKPEIHWFRGDLPLYLTENIYISPDGQVRCFVNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNI1</accession>
    <name>A0A183HNI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZFAN4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9043</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010717">
        <property type="protein sequence ID" value="VDO58485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNI1"/>
    <dbReference type="STRING" id="387005.A0A183HNI1"/>
    <dbReference type="WBParaSite" id="OFLC_0000904201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000904201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000904201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000904201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7626" checksum="E682729506DE41E8" modified="2016-09-07" version="1">VTNSRLIPAISSTITTRKETSREIENTPPDSSSYMRHMKRGNESEQNSSGPKMSTPKCKYCGAFFIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNU5</accession>
    <name>A0A183HNU5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9155</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010933">
        <property type="protein sequence ID" value="VDO58920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNU5"/>
    <dbReference type="STRING" id="387005.A0A183HNU5"/>
    <dbReference type="WBParaSite" id="OFLC_0000915601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000915601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000915601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO58920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000915601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18080" checksum="0777BC79B6F407D5" modified="2016-09-07" version="1">MKEHMLYEINLHEIRTGTYRSLFHPEQLITGKEDAANNYARGHYTIGKEIIDLTLDRIRRLSENCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKAKLEFSVYPAPQVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRFNLINDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPM7</accession>
    <name>A0A183HPM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zf-LYAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9439</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011563">
        <property type="protein sequence ID" value="VDO60595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPM7"/>
    <dbReference type="STRING" id="387005.A0A183HPM7"/>
    <dbReference type="WBParaSite" id="OFLC_0000943801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000943801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000943801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO60595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000943801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24304" checksum="905DE66F5A1355BF" modified="2016-09-07" version="1">MEFFFFKYFRDATYSCLDCGQAFSLGTYKNHIKCVTENKKYGGKNYVEKENKGEAKQNRWIEQVERAIENVTNKELKDLLQQIRGFSNIPRKEVKFINFLQNSIKIRNRDLCVKAWNCISEEAVKMQQATEKMKLEKNGGDCSSVDNEKELNCKQETSESNGEKVEEIGTGKKELKKNGVYENGNNSAEQVCTTSDRLLLIKHICLVVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPN7</accession>
    <name>A0A183HPN7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9448</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011583">
        <property type="protein sequence ID" value="VDO60700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPN7"/>
    <dbReference type="STRING" id="387005.A0A183HPN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000944801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000944801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000944801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO60700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000944801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13843" checksum="FFD32D87794389D5" modified="2016-09-07" version="1">MGFLAISYYVATTVIAVVTGIFLVLTIHPGDPTIKHDIGEGTEAKVVSTLETFLDLLRNTFPENIVQATFQQVQTKYIPVKPKIIKKNSSEILQAIANGSLTIMKPSVEYTAGMNVLGMYHFHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPU4</accession>
    <name>A0A183HPU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MTTase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9501</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011706">
        <property type="protein sequence ID" value="VDO61081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPU4"/>
    <dbReference type="STRING" id="387005.A0A183HPU4"/>
    <dbReference type="WBParaSite" id="OFLC_0000950501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000950501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000950501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552601" evidence="3">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO61081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000950501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16165" checksum="C46D63E5F4153C04" modified="2016-09-07" version="1">MASVFSFLNILCICTVLSSTFKAEPNLRFLEGISIVGVKQIECVTQAVEETLKGNCVRFLSRRKPNSNLLLPKIRKNKFIEILAISSGCLNHCTYCKTKSARGDLVSYPLDSLLERARNAFADGCKELWLTSEDLGAWGRDVDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPZ2</accession>
    <name>A0A183HPZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STPPase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9552</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011833">
        <property type="protein sequence ID" value="VDO61395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPZ2"/>
    <dbReference type="STRING" id="387005.A0A183HPZ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000955301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000955301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000955301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000955301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9221" checksum="03B22C7B855FDD3E" modified="2016-09-07" version="1">MEDVYDRRTSKPRTDILKEHFTKEGRIQEEVAVRIISECTTLFRQEKTMLDIEAPVTVCGDIHGQFYDLMKLFEINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQM6</accession>
    <name>A0A183HQM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9788</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012379">
        <property type="protein sequence ID" value="VDO63281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQM6"/>
    <dbReference type="STRING" id="387005.A0A183HQM6"/>
    <dbReference type="WBParaSite" id="OFLC_0000978701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000978701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000978701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO63281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000978701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19216" checksum="8CB2621CFD134484" modified="2016-09-07" version="1">MIATYRVLQVIRTRSYSKFLKQSVSTIQNNITYHMGLDASGSHATQTALILSDSVRLNYENLSKYVGSMVALLHTTYGISRGDRVLSRVEKSVDSLVLYLATIRLGAIYVPLSPVHTMAETIYFVEVSSVFCYWLVINKFLVYRIVIPIYLLAVILNKTRFLRIKLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQU1</accession>
    <name>A0A183HQU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9854</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012543">
        <property type="protein sequence ID" value="VDO63924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQU1"/>
    <dbReference type="STRING" id="387005.A0A183HQU1"/>
    <dbReference type="WBParaSite" id="OFLC_0000985201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000985201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000985201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="1">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000985201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20779" checksum="C7DFDE35C46A1ACA" modified="2016-09-07" version="1">MMADLLYQSNEAGKATIHFTQLLNRNPSKLIGDLKICASMSFFPSFHCLDQYYALARCIELSWRRGNVEQAEKYLRNALNTNPRATLDAGFNYCKGLHEWYTGDPNAALQAFNRARRDLEWGERATYNMIEICLNPDNEIIGGGALDYNQECNTFVFGNSFRFLLVLIDIGILIDLKLNSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQY2</accession>
    <name>A0A183HQY2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9895</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01012633">
        <property type="protein sequence ID" value="VDO64251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQY2"/>
    <dbReference type="STRING" id="387005.A0A183HQY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000989301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000989301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000989301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO64251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000989301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5139" checksum="950F7DC323009192" modified="2016-09-07" version="1">MRVCVIGTGASGLPAIKECRAVGLEVLAYERTSDVGGLWNYRPELTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRK6</accession>
    <name>A0A183HRK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013161">
        <property type="protein sequence ID" value="VDO65931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRK6"/>
    <dbReference type="STRING" id="387005.A0A183HRK6"/>
    <dbReference type="WBParaSite" id="OFLC_0001011701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001011701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001011701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001011701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13053" checksum="C1B3B8B899A20FAF" modified="2016-09-07" version="1">MNIRIVMLELMMQITDVPCYLGFISELIEGLLTIRRIGTMLPHIGLTAIERVIQRRCSLFLRHRFIPIATVTRRNVESVSNKEIKMNQNKSILEKVVMKESQTTVEKGISVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSL6</accession>
    <name>A0A183HSL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014000">
        <property type="protein sequence ID" value="VDO68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSL6"/>
    <dbReference type="WBParaSite" id="OFLC_0001047701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001047701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001047701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001047701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6632" checksum="54C7CAFFBBDE275D" modified="2016-09-07" version="1">MKYTKNGEFKKVRGRDEGCNSGGRSHEGRRNGKRSCLVGGIVEKWKSETTTTNDDNGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSR1</accession>
    <name>A0A183HSR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10523</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014113">
        <property type="protein sequence ID" value="VDO69133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSR1"/>
    <dbReference type="STRING" id="387005.A0A183HSR1"/>
    <dbReference type="WBParaSite" id="OFLC_0001052201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001052201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001052201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001052201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26177" checksum="670841E57791E8CE" modified="2016-09-07" version="1">MEFAIRQKTGQCECRPGLTGRDCSLCKDRHAFMNGVCTSCDQGCTRDLMKEMDELEEVMEKQNFTNLRPIPWKRAARISNTTKNLHLVLDSLHFGDTIGEDPTKTNIGIDGNFLDDVHGLVEQTKFMLDRTNKSKNTLQKSRAKTEELSERAREQEKIIRDVVSQLRHYINYGSGKQDSSQINAWIQEANGYLNAMKERGIYIEKRYNRGNTDFELVILKHHFANDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU05</accession>
    <name>A0A183HU05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10962</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015243">
        <property type="protein sequence ID" value="VDO72725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU05"/>
    <dbReference type="STRING" id="387005.A0A183HU05"/>
    <dbReference type="WBParaSite" id="OFLC_0001096701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001096701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001096701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001096701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8354" checksum="36334801FAF12421" modified="2016-09-07" version="1">MNEMQQEMKKSKQILEELNIAEKLKESENNLPRLEAVENTPTPPPRKRTGSEITTDLSLTEENKKLKKDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU40</accession>
    <name>A0A183HU40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKS_DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015339">
        <property type="protein sequence ID" value="VDO73049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU40"/>
    <dbReference type="STRING" id="387005.A0A183HU40"/>
    <dbReference type="WBParaSite" id="OFLC_0001100201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001100201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001100201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001100201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="44393" checksum="F443B254277AEFD6" modified="2016-09-07" version="1">MQIFTEEISTTDKYISNYKWYKLCTKKDWNNFEYELMKMIAKSYLQGDCIDWTNLYSLPPQSITLPNYQFKRESYWITENSSTIDHWLIGRLMKEEEDECIFINQISKMTNAELMAFKYDGQMRLSFGFCCEAIIQALQLTFLKDITDQSHCYSFKNITMMKYHVQENDWIKIRIKKYGDKKYHIQLTCASSIICEANIKLIASTITMQTTNIRQKENFITKTNFYEILNDKGIFYEGIYQTIINASANERIFVAKCCYRIFRIIETIIQVACYRNILNPSEIYGEKKFVIENLDFHTFLFESIYVWVENRKIVAYDETGNSMIISAELDNKKIKKKIDKTKYRKEANETKMDQLISTSSISYQKCTDKIRHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWL8</accession>
    <name>A0A183HWL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iwr1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11876</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017731">
        <property type="protein sequence ID" value="VDO80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWL8"/>
    <dbReference type="STRING" id="387005.A0A183HWL8"/>
    <dbReference type="WBParaSite" id="OFLC_0001188001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001188001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001188001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001188001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17417" checksum="502184E15A93912E" modified="2016-09-07" version="1">MLIQTGNKADDPEDIVDDDEIKDSSSSHSHSSEHEGSIFGLLSDYIFSNAVREQIQPGTSKCAVFMTADEVKDENALDHDDLEQCFETTEKIGDDHINAVNMDDEEEMTDTNHERNDDDSDKDEDKQAGPSRPRRIMLSSDEEDNIDTAPAAPKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWT3</accession>
    <name>A0A183HWT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017913">
        <property type="protein sequence ID" value="VDO80656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWT3"/>
    <dbReference type="STRING" id="387005.A0A183HWT3"/>
    <dbReference type="WBParaSite" id="OFLC_0001194501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001194501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001194501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001194501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10367" checksum="235FEBD960482681" modified="2016-09-07" version="1">MVQTEAPVIVATEKAAVDTGLSILSKAHRGLRQTEQVQIKTTSTHALSVEQQVFFKEITEAIMGSDDTRRTVRLFNFLHFIQLILQQNLGTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWU4</accession>
    <name>A0A183HWU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11962</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017935">
        <property type="protein sequence ID" value="VDO80755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWU4"/>
    <dbReference type="STRING" id="387005.A0A183HWU4"/>
    <dbReference type="WBParaSite" id="OFLC_0001195601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001195601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001195601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001195601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4386" checksum="E901DE8B4A712C8B" modified="2016-09-07" version="1">MVIRVPSPRGLGWIVAAFFIVADMVGGGIVAMPVAFLQTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWU6</accession>
    <name>A0A183HWU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017924">
        <property type="protein sequence ID" value="VDO80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWU6"/>
    <dbReference type="STRING" id="387005.A0A183HWU6"/>
    <dbReference type="WBParaSite" id="OFLC_0001195801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001195801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001195801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001195801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13490" checksum="0F0512093C5894B3" modified="2016-09-07" version="1">MKFFVFPKIILFYFAETSEIHKHEVAPISSGTKICPTSCGSGLADKKLPQNEPLHKASILPDESINTESVTFDVVMRILNRDWDPHFANRNTREFHQLAAEVINEVNAMVKTEFPEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYK6</accession>
    <name>A0A183HYK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12568</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039870">
        <property type="protein sequence ID" value="VDP11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYK6"/>
    <dbReference type="STRING" id="387005.A0A183HYK6"/>
    <dbReference type="WBParaSite" id="OFLC_0001256901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001256901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001256901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002309">
        <property type="entry name" value="Ras-related protein Ral-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001256901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20207" checksum="A0DB8AA02B5B484D" modified="2016-09-07" version="1">MGREFVEEYEPTKADSYRKKVVLDGEECLIDILDTAGQEDYSAIRDNYYRSGEGFICVFSITDSESFEATNEFREQILRVKNSAMDSSIPIMLVGNKSDLANERSVMQLHAQQKAEQWNVPYIETSAKNRTNVDKVFYDLMREIKRRKGGTLKGNVSGGDAMPRDKFHKKKRCDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ65</accession>
    <name>A0A183HZ65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3127 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12777</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039929">
        <property type="protein sequence ID" value="VDP12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ65"/>
    <dbReference type="STRING" id="387005.A0A183HZ65"/>
    <dbReference type="WBParaSite" id="OFLC_0001277801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001277801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001277801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001277801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12487" checksum="D2BA791D0E3888A9" modified="2016-09-07" version="1">MSNIVSKTACESLLPKICRSRNKCCNYLTTTLSGEAFEVGGRGEQQLVVLTENMRRESFELSISSPRVFFKEGLKKLEPIEEVIINVDDEYSGTTWKNLASVKVKITPELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ80</accession>
    <name>A0A183HZ80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12792</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039934">
        <property type="protein sequence ID" value="VDP12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ80"/>
    <dbReference type="WBParaSite" id="OFLC_0001279301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001279301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001279301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057131">
        <property type="entry name" value="Fn3_nem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24221">
        <property type="entry name" value="Fn3_nematode"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="244"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001279301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="767" mass="87019" checksum="863827F761B51D98" modified="2016-09-07" version="1">MENYARWFWMKILFKVDSITNDIIPVKTEYLDSRRIRIQMNENNVNAVVYIFEYSTVTTAPDNWIFAGVNVSSEITFTIEDACRDYQFRVIVILKTDDQDRWFIVYRPRVIPVDLPTFAITPDEIRTALPVYNAEDSTVVVYISWENPIGYTDADIYGYEGPAIYPIQCNSPEAELPSPSVELKKGGGRLRISLPSDVLEGKCRIWAEVQMLPRCIRLEPFSIQQSFELDCEKLTSLDVCKHGEVAPQCTDVIDVWGHGNNATIMWSPQVGFGAPLYYHIRYGPATVQGVSPLASWKIASLHEMKISGNSTSLQLNIDSDVDYGIQVCGVYNEHRKKPKFELARVIPFICTSCKTTPAEPFGRCGECTKIEGPLLFARRCHPKETNFQIIRENLDTTTLQPSAESTTKLKTSLSEISVHLAPSKTQTTKQPTREISASINRAKLTTALNNNTLRKVQSTLMLNSRTIVEVSKSVQASQAVTAPNKNKLQSDLNSCTLPNGAICEFGCIDQTKCNCPQGTHHVLMDGGSCQPSDPRPSFRCFSTADVKAIWNPWMHTLQIQSNKIHNEIKMRTDYDRIFLEFGRVKHTVKGKSSSNKVIFDEQNEKNNKVIIRTNKILQNGLFLTAPYTFYTNQTIDPITYQYGLRICAFNNSKIKNPFTVNWTQGTVQSIFHLSTVQFEHGFVGNIISNEKKQMTKMAFVIIPTILIVLLVFFLAIIIYLNCARLKRCYDRRKTRNFRPFVWNSSIPPMTNGTVHEKRTCIVTKSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ95</accession>
    <name>A0A183HZ95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12807</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039941">
        <property type="protein sequence ID" value="VDP12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ95"/>
    <dbReference type="WBParaSite" id="OFLC_0001280801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001280801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001280801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001280801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13698" checksum="35FDEB3143247ADC" modified="2016-09-07" version="1">MTVSTYPSNGRSSLRYEQEGKTVQDMINPVYLVFSFIEKFYASMPYISLRCRNEGCERLCRLRRQGIARALCCLSDAGVVAAVMSACSSGSSNLAICFCHRFALDGSAARWDGWGLHARIQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH6</accession>
    <name>A0A183HZH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039964">
        <property type="protein sequence ID" value="VDP12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH6"/>
    <dbReference type="STRING" id="387005.A0A183HZH6"/>
    <dbReference type="WBParaSite" id="OFLC_0001288901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27866" checksum="AED4C8203EDFB78D" modified="2016-09-07" version="1">MIVKVLVTAELQRETEKVKRIFDLVMVLGKTRKSKNLPDSEIINGIELIGNLNEVDMHQLQKMIAEVQEESELIIVFNLLQINDDVNQLYDILLFNPDRISNAEMLSDVNQNQNNEIHRHAVIDRLLSTKLPIGYSELLGCSLSDEYYHLAISINLKPIDIFKLSLTASFLTEKTPRNGKHEFFPFTQQYDEFANWYNLENSNEWKFQILRNYQFFLSRPLTSRRKRRRRRIIDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZI6</accession>
    <name>A0A183HZI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piezo_RRas_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12898</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039967">
        <property type="protein sequence ID" value="VDP12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZI6"/>
    <dbReference type="STRING" id="387005.A0A183HZI6"/>
    <dbReference type="WBParaSite" id="OFLC_0001289901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001289901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001289901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="2">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001289901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29626" checksum="B312585EE100A530" modified="2016-09-07" version="1">MKYELKEGTKVLNAIIRFTFERPNSKHADYPTQHYYTLTIPLPVNSTVRTELVKIVNGQYNHSILLENAWPPYVIMPNEGNAKPAWSLLHVISGSNPKSWEAFSNISMKLKTTRTAESKIWCARVIENNETAALTLPLEDIKYEIRPEKYLQMVVFVDRVFPSFVSKYVQGGIIAMYLAVVMLVGRMIRGLVMNAGMEVMISEIPNPDHLLKICLDIYLVREAKDFILEQDLYGKLIFLFRSPESLIKWTRNRVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZR8</accession>
    <name>A0A183HZR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039998">
        <property type="protein sequence ID" value="VDP12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZR8"/>
    <dbReference type="STRING" id="387005.A0A183HZR8"/>
    <dbReference type="WBParaSite" id="OFLC_0001298101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001298101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001298101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001298101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9892" checksum="4F9F043C8C391C94" modified="2016-09-07" version="1">MKVKNISGPTLEFYNVPYSLNLHLQFYRFLNVAELSYDFLSNRFRNYNDLFNARNYMEGLNDVITESVQKIIDHFNVSLILHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZX4</accession>
    <name>A0A183HZX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13036</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040021">
        <property type="protein sequence ID" value="VDP12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZX4"/>
    <dbReference type="WBParaSite" id="OFLC_0001303701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001303701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001303701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001303701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8897" checksum="EC34F7A085E7D112" modified="2016-09-07" version="1">MELFTIKHSYDSTHNVLALLISSRNSGRKHPIILNLEIKPPNIIISSLYDRHVEKNNLVTTACQQRLGFPDHLRSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0V2</accession>
    <name>A0A183I0V2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040165">
        <property type="protein sequence ID" value="VDP13557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0V2"/>
    <dbReference type="WBParaSite" id="OFLC_0001336501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001336501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001336501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001336501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16757" checksum="A1BB983711706060" modified="2016-09-07" version="1">MVLNFLHKEKFFEWKNENKIRRGLDVTVDVTVNINDFEIIQSQEQQAIEFDSKDKIKIKGWCSHEAATPRPTISIMLSVRVVLLFEAPSSSKFSKKAALKQGRLRCCSNLSILSVRSVCYCSISAAISVNVVDDDKNGNSSSGNRELSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0X2</accession>
    <name>A0A183I0X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13384</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040172">
        <property type="protein sequence ID" value="VDP13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0X2"/>
    <dbReference type="STRING" id="387005.A0A183I0X2"/>
    <dbReference type="WBParaSite" id="OFLC_0001338501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001338501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001338501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001338501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24982" checksum="DAD590E5B75EA31D" modified="2016-09-07" version="1">MKEEITGIPLYNFQLVLVETQLWIWDREITSLMILDDALDPHSDLRYIFLFMEWSMHGALWLIFSSFIFLVSMRYSFSLITRYELTVLILGLCVDLIIVGVVKGIVRRPRPPFDIKDQLYEAPLVDKFSFPSGHSSRGAILKFCSLPHFIIPFVKLFPFVLGASRICIGRHYVSDVIMGLLLGYAEGNFVQYLPLYTVDLLKQMFPLIFGSNEQGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Z6</accession>
    <name>A0A183I0Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040185">
        <property type="protein sequence ID" value="VDP13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Z6"/>
    <dbReference type="STRING" id="387005.A0A183I0Z6"/>
    <dbReference type="WBParaSite" id="OFLC_0001340901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001340901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001340901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001340901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18730" checksum="3B0FD207F78AC04C" modified="2016-09-07" version="1">MRQPVTSYEENEIRGCCCNRKVGIESAQLTVSDMGLLPGEIAKITLVIEDGAKRKRRKSRKNRNDCVLLSLCQQLDFLSQNRYELHLFDRKSLTIAVESIGTCKVTSDTGPEIRHIDFQIPIGLQPTSVKANGLITISYFFRLDMHSFDVIVPVIIGSMKTPGSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1P4</accession>
    <name>A0A183I1P4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS13656</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01040318">
        <property type="protein sequence ID" value="VDP14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1P4"/>
    <dbReference type="STRING" id="387005.A0A183I1P4"/>
    <dbReference type="WBParaSite" id="OFLC_0001365701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001365701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001365701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="8">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001365701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33608" checksum="C959D42D272BB5E3" modified="2016-09-07" version="1">MWSNNEISGKAVVLATGGFSCDHSKEDSLLQEFAPEKANFPTTNGPWATGRGVKMARAMGAALVGMQNVQIHPTAFVDPKDPAAATKFLAAEALRGKGAILLNDKGERFVNELDRRDHVTDKILKSCARSEEAGGAYTAFMVMDNQAVDDFGRASFDFYAKIKGFFKKFDTLDEMANYMKIKPSKLKATLDEYNEHAHSASSREDKFGKKIFPIALEHPPYYVAVVTPAIHYTMGGIKIDKDAVVYNEFSGKPFKGLLAAGEVTGGVHGRNRLAGNSLLECVVYGRIAGHNAAAIRYSASDATLTRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1Z8</accession>
    <name>A0A183I1Z8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13760</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040379">
        <property type="protein sequence ID" value="VDP14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001376101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001376101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001376101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF17">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001376101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35605" checksum="ED189ADA42B486A5" modified="2016-09-07" version="1">VNFSFEFLYSAIHFCDPSIPNDCGFEGKCIRQLNGNRCRCPIGRMGIMCRRPCQDIYKSCKHWKEEDRCRWARPISPFFEDNCAESCGICKSNGRSLKIPLPPILEPISWIIGRWETVTSAGDRFPVSFEHPYKEILDISLAEAPMFDRPPVNISFYLVFNPFPLQYLILNXXXXPLPLHVRAHTNEGSEYIEVGFMTGKPSVELTGFIKSNQSLNENDQVAIEMVSNTGIITIEEGILRDNEISLTLKYNQGIPKASQYFLKKSRRSFKLKNWNILMEKTVMELSNGTIRKWLKRYRRTKDYLMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2G3</accession>
    <name>A0A183I2G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13925</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040475">
        <property type="protein sequence ID" value="VDP15025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2G3"/>
    <dbReference type="STRING" id="387005.A0A183I2G3"/>
    <dbReference type="WBParaSite" id="OFLC_0001392601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001392601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001392601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="39"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001392601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="59061" checksum="4AEFC85BDF9DA8A3" modified="2016-09-07" version="1">MEDSGKKCSVVDEVLIKDGKCKRSVNRSLPTAPPDGGYGWIIVLASFFANVIVDGIIYSIGETLVENWERDFRTTTMQASIAQSLLAGFYFLAGPLASGLANSFGCRLVVIAGSIITFVGFILSSFVISLPILYITFGIIGGLGFGLVYLPSILIVNQYFEKRRALAMGIAVCGSGIGTTVFSQLFPFLLEVCGNSWRHFLVYAAFTTLFSVLCGLCYRKIPLVTEDNEDKPVKSNFDLSREGNDGYDSLSSHIAINYPISMNNNSKAKMPRSNFCAIINRKLIDLKVTRNGRKGNLVMTPKTTIQVIPQKARKQFSLHTILRSMVDTSLLSDPSFILIAITAFMTLCCLFVPFIFLGKQAITVGATPNQQSYLLLVIGLVNTFGRILCGLISDLSGVDPLVVHNLGVIIGGIATCIVPLLTRYWMYMVYTVPFAWSVACFSSLRAIICIELLGLEKFSNAFGMMMLCMGIAALIGPTLAAMIKDLSGSFDLSFYVMGLLLTMSGVLCMPLRKIKSRIPNLRSPKNNRQSELQSVTERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Y7</accession>
    <name>A0A183I2Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040597">
        <property type="protein sequence ID" value="VDP15487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Y7"/>
    <dbReference type="WBParaSite" id="OFLC_0001410701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001410701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001410701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001410701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8912" checksum="F6A1EF6DB8264437" modified="2016-09-07" version="1">MQFAFGDRPTHFKSQIGKMQGHLKLLFKKGPLTLGDMKMKPVNIVKTEQQECGSSSKIRHQRMLSFIDKNYERTLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3F9</accession>
    <name>A0A183I3F9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS14271</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040729">
        <property type="protein sequence ID" value="VDP16277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3F9"/>
    <dbReference type="STRING" id="387005.A0A183I3F9"/>
    <dbReference type="WBParaSite" id="OFLC_0001427901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001427901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001427901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP16277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001427901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31561" checksum="A96CB279F9E58396" modified="2016-09-07" version="1">MQCGRLSVIINDSRLSVIRYSSFLDAATTAPGTSDATTDSSSNLLEEQCGSKNTKVVSRLTERHRLIAEGRLPPITYEWEKKLWAKRERFGTYGLASGVKPEELWPSIEEIQEEEAIGWYMKYNDVLKDVENAKKSKHAATLARLKEVAALEEKYPEKLKEFLENQKEVVPVKSKQELEAEQRAKDMLEYYGYEILPNDPRFPILFERMTEGKKKVSCYHPLMKCRFSSFFFFNEISVFQAVKLAEKEELSLKKHASRKKEKEKKQEKKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3I7</accession>
    <name>A0A183I3I7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14299</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040748">
        <property type="protein sequence ID" value="VDP16404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3I7"/>
    <dbReference type="STRING" id="387005.A0A183I3I7"/>
    <dbReference type="WBParaSite" id="OFLC_0001430701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001430701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001430701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="10">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="9">
        <location>
            <begin position="40"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="9">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="8">
        <location>
            <begin position="468"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP16404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001430701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="805" mass="90351" checksum="7881400430B71AD5" modified="2016-09-07" version="1">MLANMSDRDLSELNECPLDPGGYFVINGSEKVLIAQEKMATNTVYVFSMKDGKYTYKTECRSCLENSSRPTSTLWVNMLPRGGGGSKKSAMGPKIIAILPYIKQEIPVMIVFRALGFVSDHDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGARGAKPGVTKEQRIKYAREILQKEMLPHVGISDFCETKKALSDIAILIDFSTISRKFIIKYFLGYMVHRLLLAALGRRELDDRDHMGNKRLDLAGPLLAFLFRALFRNLLKEVRLTAQKYINKNGDFMLDLCVKTPLITRGLAYSLATGNWGDQKKAHQSRAGVSQVLNRLTYTATLSHLRRCNSPIGREGKLAKPRQLHNTQWGMVCPAETPEGQAVGLVKNLALMAYISVGSLPEPILEFLEEWSMENLEEVAPTAIADATKIFVNGAWVETVMLAMMPEDLKAGGYCDTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYTTNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFNELPAGINAIVAILSYTGYNQEDSIIMNQSGIDRGLFRSVFYRSYRDQEANLDNANEELIEKPTRDKCSGMRHSLYDKLDDDGIISPGMRVSGDDVIIGKTISLPDTEDDLDATIKRYTKKDASTFLRSSETGIVDQVMLTLNTDGNKFVKIRVRSVRLPQIGDKFASRHGQKGTMGIMYRQEDMPFTNEGITPDIIINPHAVPSRMTIGHLIECLQGKLSANKGEIGDATPFNDTVNVQKISNLLQEYGYHLRGNEIMYNGYTGRKLTIQVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4W1</accession>
    <name>A0A183I4W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1778 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14773</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041178">
        <property type="protein sequence ID" value="VDP18690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4W1"/>
    <dbReference type="STRING" id="387005.A0A183I4W1"/>
    <dbReference type="WBParaSite" id="OFLC_0001478401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001478401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001478401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001478401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8479" checksum="1D5D96A76278422E" modified="2016-09-07" version="1">MGKSKSNLHSNTDVKMEVEEDVKPSVNDLGDKSIVGTPMSAKVGQDEYDELCSMVNAIAHPLASRKMAKKIYKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I635</accession>
    <name>A0A183I635_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HisK-N-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15197</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041749">
        <property type="protein sequence ID" value="VDP20789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I635"/>
    <dbReference type="STRING" id="387005.A0A183I635"/>
    <dbReference type="WBParaSite" id="OFLC_0001520801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001520801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001520801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF394">
        <property type="entry name" value="APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAP3K HisK-N-like globin" evidence="6">
        <location>
            <begin position="171"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP20789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001520801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27805" checksum="E62D661A2A55A6BD" modified="2016-09-07" version="1">MPCCRIESLTYPPTSLISSRNSSMALMIRLVSWSINLHVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVELGSPQAAMFKVGMFKTHPPIPDGLSERCKRFILRNRSGNTTKKHFEAWKYNRDDSTHPQLNSSSLFSSPSVNGIAPSFVNSSSLNRTASDESGLSSRFFMLKKDSERRNTLARFMLDYKIEIIDNWYEHLTKSQLTGDLVVTKEMLLTLLLGMRNYLFSKNTAPIQVQYTCICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6K8</accession>
    <name>A0A183I6K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042025">
        <property type="protein sequence ID" value="VDP21556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6K8"/>
    <dbReference type="STRING" id="387005.A0A183I6K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001538101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001538101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001538101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001538101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10178" checksum="A3CFF42480551C78" modified="2016-09-07" version="1">MNPQTDLILFVENEDNHGDYLRQTKDDISPQATKKQKLENGLLNYLPSSKGNITSTSAPNSLKPLVNGDVKAAVTSIQAVSRSTPATPAGSVQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7P3</accession>
    <name>A0A183I7P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042789">
        <property type="protein sequence ID" value="VDP23673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7P3"/>
    <dbReference type="STRING" id="387005.A0A183I7P3"/>
    <dbReference type="WBParaSite" id="OFLC_0001576801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001576801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001576801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001576801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29837" checksum="64E95C29C13C71E0" modified="2016-09-07" version="1">MLLTWVIDDVVAGGYMEVDAEQLMRINSKKAKEEAVLRAAAASTQGSIIPKVLPPTSFARSTETSQYDCRNATQGPPHHMQQQQYGTSSYHMQQSLQHQQSQMLQQIPLQQMSLQQQQQQHLLLHQQQTANNMQNITSAVNAGAIHAVSQLPDGRQQVLQAAPSQQQASRLVAQSHLQQQQSINYGSPMMTSTCNAAAVIAPQTVPAASRQLDLNKQMGLSAAPLQESVSSNSYDLYANLPKKSTIGAAQSQHQQQVVFINSSLYLSILYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7Q8</accession>
    <name>A0A183I7Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4417 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042830">
        <property type="protein sequence ID" value="VDP23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0001578301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001578301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001578301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001578301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17514" checksum="C28A84E4D0B15BCF" modified="2016-09-07" version="1">MNLQKALQRWQPRFALLFADINNPTPTQYMPFDCLYFQIVPYNDRLGIFLNFRTDGTLGENHPRSAVIIPKMYDVPVKFMYCGDHNNWCLSTDGEWSTAMRNAKLIILFRTTVREPYDIESVINTEIAPYIENQSVSICFAHQLDEAGFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7T3</accession>
    <name>A0A183I7T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15794</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042901">
        <property type="protein sequence ID" value="VDP23912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7T3"/>
    <dbReference type="WBParaSite" id="OFLC_0001580801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001580801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001580801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001580801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15571" checksum="88C459F4B1FF6B8E" modified="2016-09-07" version="1">MKKDDFKVIRDRVIILDADSKYFAAFAYPLIDSNIPTDIRLYISGNMDSGLELFPTYIVSQIRYLRRGKSMIEVAGVYIFGADVPQRTNEANEKVPQNEGVRHALTVILETEKRMNLWVNEKYGSEKKREYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I803</accession>
    <name>A0A183I803_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15865</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043090">
        <property type="protein sequence ID" value="VDP24408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I803"/>
    <dbReference type="WBParaSite" id="OFLC_0001587801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001587801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001587801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001587801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11056" checksum="D1005C5B179373CC" modified="2016-09-07" version="1">MGECLPRMSLHSREIVLVDEEIALGQSTGSLHSRNSRDASLLRVARIASVSCPSERISSLVVVTSQSSRYGGSRIVGTGRRNQSIVPPNTTTGMGNDNDDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8F7</accession>
    <name>A0A183I8F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YbbR-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043621">
        <property type="protein sequence ID" value="VDP26071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8F7"/>
    <dbReference type="STRING" id="387005.A0A183I8F7"/>
    <dbReference type="WBParaSite" id="OFLC_0001603201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001603201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001603201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001603201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8791" checksum="3EC09086EE766490" modified="2016-09-07" version="1">VFVPAYGFESIVVFPSGSNYQVTDDSLIAEGVEVRSFQRITVKLSLDETDVQHIRLDMKLVSPKIPGFSVDYIISAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UQ26</accession>
    <name>A0A3P7UQ26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000108">
        <property type="protein sequence ID" value="VDO25484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UQ26"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="129" mass="14600" checksum="E93E2A550AED86A4" modified="2019-02-13" version="1">MSFKPTHLTVECESRNHAGQVDDERHFFVQIASNNFEGLQAIQKSKTFHHNILEFVTQFSISNQSIPHLEMVSIAGAYMHRLINNCLREELAGPVHALRIDAYATSKFSNNPPTIPPKCAQNHTDHFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VHF6</accession>
    <name>A0A3P7VHF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006406">
        <property type="protein sequence ID" value="VDO47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HGK9"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="103" mass="12186" checksum="FC57F7D2A4D5EABC" modified="2026-01-28" version="1">MEDLNFQMYLETLAEKITQLLKMMPTACGFCLFKELENERKCNAISHFILRLAFCQTSEQKKRFIQQERSRGCFHMNKYSYGLSIIGHHKNWFGIHCAVLIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VRN3</accession>
    <name>A0A3P7VRN3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Trehalase</fullName>
            <ecNumber evidence="2 6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 6"/>
    <dbReference type="EMBL" id="UZAJ01007663">
        <property type="protein sequence ID" value="VDO50676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VRN3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF12">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO50676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="248" mass="29472" checksum="8E22211479714644" modified="2019-02-13" version="1">MVFIYKVKDDVRQHQELYSLLYVPHPFIIPGGRFREFYYWDSYWIVKGLLFSEMYETAKGIVRNLAYMVENHGFVPNGGRVYYLFRSQPPLLVPMVYECYLATGDLEFVQEILPMLEKEYNFWMLQRARSLHDEKHGLNISFFQYRASMKTPRPESYREDLELAKDLHSMAEKELMWSNIASAAETGWDFSTRWFAQTGPERHDMKSIRTWSIIPVDLNAFICINARIMASFYEITGIFFFSSILRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W6E8</accession>
    <name>A0A3P7W6E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Far11/STRP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009823">
        <property type="protein sequence ID" value="VDO56336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W6E8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="248" mass="27914" checksum="0FD88D7657D4187C" modified="2019-02-13" version="1">MDHKWSKLTESQQKDILLNLLEELERVEPNIRLNAARSILYILQGAYMDFVDDRDITIGDTFQGNSERQSGNDVNIGHCEEKCLMEGVLNAYKAYEVGAYQALCKLLLTEIHDIWDGGAVGAGQYSQLSSVSNSRSASNADLSESVVERRSSRRSATMADNEALRVTLSALYHMVESIRRSDLFELIVSADKKSRYAELKKDFIAEVEEMIEGADMSLIMVLLEMMPAFCHGSSPHFPMKKVVFLVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W7N0</accession>
    <name>A0A3P7W7N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010030">
        <property type="protein sequence ID" value="VDO56911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W7N0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="172" mass="18820" checksum="2AEEF822B2955EDB" modified="2019-02-13" version="1">MPSPNSQFSTDAISYRQSLGGNSSERSSTFAAISAVVTKANSGKFFAPPPSAASLSTYGVVKPAGMRVHIQHGGADFMRNRRKQRHRARTDSTRIHSPPPSYSKIRVECSDDESQQLQVPTNSRIVSSIDSSSVESTRRILLPSGHFISSIEFAQQQHLFDYSSTSSDVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X5A7</accession>
    <name>A0A3P7X5A7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000032">
        <property type="protein sequence ID" value="VDO24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X5A7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22542" checksum="5DB1BF2A319C0404" modified="2019-02-13" version="1">MWNFIKCEFQVNYLSQFYLLNELIGVATPKEGVKIITLTSILYKFLCPKISSKYDCMQKMFSPSSGTSGWLSYARSKLATAMLACYLDRIEGIQAVGVHPGAINTAISSNISPRMRKFLKTMQVSRFLTRVEDGARNVVECVEGSHLSNTYRNNTKYDSVPKRVSDERNEINLMILSKEMIASILPDFRVNRILYNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AK34</accession>
    <name>A0A3P8AK34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040424">
        <property type="protein sequence ID" value="VDP14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="84" mass="9355" checksum="70B13FC2439D2935" modified="2026-01-28" version="1">MCGEDKWQMVSTSSVCNLHKSRKMGISGLWYSNSDCIEGIDAYVQRKAVNNTHPSSLFPGDAEVSPRLRTRIPGVIPGILTEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ERA1</accession>
    <name>A0A3P8ERA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040350">
        <property type="protein sequence ID" value="VDP14459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="59" mass="6900" checksum="74C011136A119D64" modified="2026-01-28" version="1">MNFIAQLRDLIKFYLGHYNSSTKSSECVLARQATSLVILHIRDTGRLFLNVEKSRRNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FPG4</accession>
    <name>A0A3P8FPG4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042971">
        <property type="protein sequence ID" value="VDP24133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FPG4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="60" mass="6942" checksum="8A46E90EFA33524A" modified="2019-02-13" version="1">MFQVKLLCCVTSRPAKYRDPLTGLPFATPEAFKLIREKYAEYLKSMPSHPAVKSWLAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ55</accession>
    <name>A0A183GZ55_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin maturation protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin aminopeptidase ACTMAP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS515</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + N-acetyl-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:74579"/>
            <dbReference type="Rhea" id="RHEA-COMP:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:18395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64720"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
            <dbReference type="ChEBI" id="CHEBI:193599"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:74580"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ACTMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000177">
        <property type="protein sequence ID" value="VDO26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ55"/>
    <dbReference type="STRING" id="387005.A0A183GZ55"/>
    <dbReference type="WBParaSite" id="OFLC_0000051401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000051401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000051401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040043">
        <property type="entry name" value="ACTMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631:SF1">
        <property type="entry name" value="ACTIN MATURATION PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631">
        <property type="entry name" value="UPF0692 PROTEIN C19ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21646">
        <property type="entry name" value="ACTMAP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000051401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27427" checksum="3B99AF45E3031C1D" modified="2016-09-07" version="1">MTLLPTLSPLAQRRILSVLNDCPENVENRGGAVAFVRNVEPILQNGPQCGLVAIQMVAQAYGLPTRNIDEIFQLAKQKGYTNYGEMFSADWLADIATSLWPMLNIVVENVPSTAEMEQLIQENALLLMPYDCDKNHQPSNRRGHNAHWCLIIGFLCPVKELETVTWNATIAHTCSKVTHVFCIHGKSRHLAVWNYSQLIASNFNLREASNKLIDYVIPSSDLSTLRNLCLVVRCHHSITAFNAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0T9</accession>
    <name>A0A183H0T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1099</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000471">
        <property type="protein sequence ID" value="VDO28234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0T9"/>
    <dbReference type="WBParaSite" id="OFLC_0000109801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000109801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000109801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO28234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000109801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="35120" checksum="222C33DCB15F622C" modified="2016-09-07" version="1">MKLFEHKQQELQRISAEIHRLSQGNPQQQRKCVRLKEDYERLMQEIQKLQENQNKDKIRLDELRKQIEQIEASEENEESKKRKRKKLEKEYEELRKKLDVGEEFKENAEKINGSNGSNENTFSFKSAENIYLNEQHPEVKPVQKDQYGVYEQIRNIKTIEERMLKRKKIESEAEDTFTIRTANLCELEADIDNVRKRMASPVIQKFEEELKFIRKKSSKDTKMLKKEITELERRIDKINRTREICVTAIAEMNLTTKRMLFDLMGFVVNILRNVLYIIAWIRDLLIYYTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V6</accession>
    <name>A0A183H0V6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="13">1.14.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS1116</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="13">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROX family. NO66 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="13"/>
    <dbReference type="EMBL" id="UZAJ01000479">
        <property type="protein sequence ID" value="VDO28304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V6"/>
    <dbReference type="STRING" id="387005.A0A183H0V6"/>
    <dbReference type="WBParaSite" id="OFLC_0000111501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032453">
        <property type="term" value="F:histone H3K4 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000013">
        <property type="entry name" value="Ribosomal oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.40:FF:000001">
        <property type="entry name" value="ribosomal oxygenase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1500">
        <property type="entry name" value="JmjC domain-containing ribosomal oxygenase (ROX), dimer domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049043">
        <property type="entry name" value="WHD_RIOX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21233">
        <property type="entry name" value="WHD_RIOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="389"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO28304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="84588" checksum="E4FB436D4B6BB338" modified="2016-09-07" version="1">MTIPSSNDRSKNGKACKNFIERNENALVSSFLSKNADKCGEKTNKINETKNKERKLTKKEIQEGNKRKRKSVDKGELNGSAITQSQVHSNDSVFSSLFREYDRSEKMQNSLKHNISDKALQSFGKKGKRKMQKKIQKIVHNGEVVDCLNEEEETEENKILILPDSKDEKFFEVDETGGKEKGMKNREEYGGKFQLHDGIRVSSSFLDDVEIKHNLFLLFQINFLKLHLNNGYIFIQSRIMRISDEENQERTADTMVYENFVKCYRTKNNGNVHGAIIDFEQKPFSAHSDSIQNGLDAMQWLIDPYNIKQFFKAIFQKKVFYMCRNNPSYYGNLFSTAKFIDILRADYVEYGTNVNVAIYKNQQRSTLNGSGKVYPQEIQKSIKAGCSIQFTNPQSFCDNVWYFCDLLQEIFGCFVGANTYITPANTAGFAPHWDDIDAFLLQLEGRKHWKVYAPIDDSEMLPRLPSGNFTDDDMTNRTPVFDDWLEQGDLLYIPRGFIHQGFADKDVHSLHLTVSVCRNVTYADLLERVVPLALSSFAEQHVNIRKSLPAGYLDMTGVLECDYPLFKTGALKLDRFLDAIFSNFCNYIKGLIESAVDMMAREFMKTALPPLLTKEEKDMTVSRIVGSSLYDDKQHIFTKDTAIKLLRRHGQRLIYESEERCFIVHRMANSRVYEGRPEVLFDMDVKLAEGFANLMDAYPQWCLVSDLKCDTVVDSIRLAELLYSNGLLMAKFPKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H132</accession>
    <name>A0A183H132_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1192</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000526">
        <property type="protein sequence ID" value="VDO28604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H132"/>
    <dbReference type="STRING" id="387005.A0A183H132"/>
    <dbReference type="WBParaSite" id="OFLC_0000119101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO28604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44182" checksum="FAE4C1D92CB8A514" modified="2016-09-07" version="1">MDASNGLTCLCCQAVFIDSNQQREHYKTDWHRYNLKRKITGFPTVSEEQFRQKVIAYKKETTTENNAETKMIICKCCSKQFQSTNAYDNHLSSRKHKESEIRSLKGNPKMRTAKAPVTEKQINDFYDNHFDEEDIQESDCDDSDGWITDHGTDEEDFDESKVIPETICLFCNFGSNSVETNLMHMSKLHGFFLPDAEFCTDVSGMLYYLGLKIGSGNMCLVCNERKRFSSLDACQKHMRDKGHCHVASSMKEMIEFEDFYDYSSMYPEGEDIDNSCPIVLTDSGYTLTLPSGAKIGHRSLLRYYRQHLKPVGYEIRSDRQKKEILKRAVIGQYKELGWKGTSGTVAVQRAKDVRYMKKISSKNWIKLGLNNNRLFKSRGRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1U3</accession>
    <name>A0A183H1U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000686">
        <property type="protein sequence ID" value="VDO29594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1U3"/>
    <dbReference type="STRING" id="387005.A0A183H1U3"/>
    <dbReference type="WBParaSite" id="OFLC_0000145201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000145201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000145201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF352">
        <property type="entry name" value="SYNAPTOTAGMIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000145201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12135" checksum="CE6432C7A7836348" modified="2016-09-07" version="1">MSIRILENTIPNDPVPSIPHETFTQPNVSTKIPDDSPSFGNIHYKLDYDFGSNNVSCKLAVTIFGCSDLPAMDRNGMSDPYVKLCLLPEGKQKYETKIKRKCLNPIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3I1</accession>
    <name>A0A183H3I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2041</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001099">
        <property type="protein sequence ID" value="VDO31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3I1"/>
    <dbReference type="STRING" id="387005.A0A183H3I1"/>
    <dbReference type="WBParaSite" id="OFLC_0000204001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000204001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000204001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000204001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26963" checksum="80A506F3FD905F86" modified="2016-09-07" version="1">MTMEKKARKKLENERADQECELEKLKENVQKTMAKIETLKESCREKDKEIRRLEKKLDQTNEESETNIAEMKKIHKRSKDELQNRLDELKKAYQKLEAESKSQKMKLEISEKERESSIESDYVSGGRQSRMGSRQYSSSSIGSLGSIRTLSRRTVEPENKFSSGFRSPSTFSLSYYSGDPYNLSRSSSQSQFANDRKISQLERQIISAHTDTQMMRREIEVYKSTLTENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4T8</accession>
    <name>A0A183H4T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2498</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001447">
        <property type="protein sequence ID" value="VDO33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4T8"/>
    <dbReference type="STRING" id="387005.A0A183H4T8"/>
    <dbReference type="WBParaSite" id="OFLC_0000249701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000249701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000249701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000249701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7454" checksum="26F5D0F101E62256" modified="2016-09-07" version="1">MYYYFAICSALSAIDLSAIAIAYELRALDRKLNIGRYPMVDYPEMYLLQYGYSSFYLRYNEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H545</accession>
    <name>A0A183H545_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2607</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001530">
        <property type="protein sequence ID" value="VDO33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H545"/>
    <dbReference type="STRING" id="387005.A0A183H545"/>
    <dbReference type="WBParaSite" id="OFLC_0000260401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000260401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000260401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000012">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000260401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25918" checksum="4BB61195B0DAB3D7" modified="2016-09-07" version="1">MGESDHYGFSLTTFSPSGKLMQIEYALNAVKNGQPSVGLRASDGVVLATENKISILYEDQPKVEKISQHIGCVYSGMGPDYRILVKKARKLAMEYELMYGEEIPTTQLVTKLAAVMQEYTQSGGVRPFGVSMLVAGWDHEPNPGRPLLFQCDPSGAYFAWKATALGKNDVNAKTFLEKRFSDALELDDGIHTALLTLRESFDVGMTEDNVEIAVCNKNGFMRLSKQQVKDHLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H645</accession>
    <name>A0A183H645_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS2954</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001842">
        <property type="protein sequence ID" value="VDO34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H645"/>
    <dbReference type="STRING" id="387005.A0A183H645"/>
    <dbReference type="WBParaSite" id="OFLC_0000295501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000295501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000295501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000295501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19215" checksum="224C520276D2DB34" modified="2016-09-07" version="1">LCEADNGGCSHSCLSIEDREVECRCPHGLVLDSDKKTCIKPIPKNLCRILSSCSCTAIDENQYSCTCPKGEKCLLLRGRPKIYIEPAAPYEIMPGGNLNITCSAVAYPFPQIFWQRGDETVEIAPVKPGTVRSEQILIIKELYKNTQFTCHANNSLGQAERTIEIVVTGRFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6K5</accession>
    <name>A0A183H6K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3116</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001985">
        <property type="protein sequence ID" value="VDO35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6K5"/>
    <dbReference type="STRING" id="387005.A0A183H6K5"/>
    <dbReference type="WBParaSite" id="OFLC_0000311601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000311601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000311601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000311601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14729" checksum="25CBB96D82C4D9A1" modified="2016-09-07" version="1">MLAVSATNSDQSSDTSTHFNALLPLSREECETVSQSDNSNACSTKITRIGRSKASVSLATIDDMGRYRPMYDNSYSISDNKGNTRRKLKNKLDKYLHYSMKKEAEVADQIAQLIVADVHNMVSAGSSLRLTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6S8</accession>
    <name>A0A183H6S8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3190</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 9"/>
    <dbReference type="EMBL" id="UZAJ01002058">
        <property type="protein sequence ID" value="VDO35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6S8"/>
    <dbReference type="STRING" id="387005.A0A183H6S8"/>
    <dbReference type="WBParaSite" id="OFLC_0000318901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000318901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000318901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000318901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42168" checksum="1069A06A0133B150" modified="2016-09-07" version="1">MLFEIILQNLHAIAKEKINNFIRGHFHGHYDFDLDKTLYMFTAGRYEFINKGGDIFIESLARLNHYLKTTVDPRYRDVTVVAFIIYPAAANSFNVESLKGQAVTKQLRESIDKIKESIAVRMFESCLKGHILNTDELLLPAERIQLKRCIMATAKRELPPVCTHNMLDPSDHVLNALRRTHLINNPGDRVKVIYHPEFLSSASPLIGLDYEEFVRGCHIGVFPSYYEPWGYTPAECTVMGVPSVSTNLSGFGCFIQENVMDAASYGIYVVDRRFKDCEGSIRDLAQVLYDFCGLSRRQRIIMRNRTERLSQLLDWKNLGVFYREARRMALERLHPNLDEIIENNIGKVPSASQSRQPSFTDIYESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6T2</accession>
    <name>A0A183H6T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3194</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002062">
        <property type="protein sequence ID" value="VDO35618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6T2"/>
    <dbReference type="STRING" id="387005.A0A183H6T2"/>
    <dbReference type="WBParaSite" id="OFLC_0000319301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000319301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000319301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000319301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24161" checksum="CBC9DF34DF06B709" modified="2016-09-07" version="1">MYDAWAQIARALFYQYGNAFSFLTLLDALCSDFVKSIPVEEYSRTLQQELESVACKLHRCEPLPLSYPEIIIPFMQPLLNILSNNLSSLDDVDYRTTWATDVGKFLRLVRDTLLFQNPFACYGSISLHVYNLWKWLQEGRRWIKRAIQLDSDSSKLCNGKIPHSDNFLSTEFSLKLLFGSKDFSTDRKKRYGKLAAMADTLKKRCSLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6X8</accession>
    <name>A0A183H6X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3240</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002105">
        <property type="protein sequence ID" value="VDO35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6X8"/>
    <dbReference type="STRING" id="387005.A0A183H6X8"/>
    <dbReference type="WBParaSite" id="OFLC_0000323901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000323901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000323901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000323901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11341" checksum="EB7A34B3CBD62191" modified="2016-09-07" version="1">MENINSIRVLSPMIAFHSLFMVFYLGAFFLYFTIDFNSSHTQVAICLECIQQTPTYALILPIAIVWAEKYVKKITQKNRQKAMELKGTEAANHYFVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H728</accession>
    <name>A0A183H728_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette sub-family A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002160">
        <property type="protein sequence ID" value="VDO36003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H728"/>
    <dbReference type="STRING" id="387005.A0A183H728"/>
    <dbReference type="WBParaSite" id="OFLC_0000328901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30742" checksum="79DB958EB7CE52E9" modified="2016-09-07" version="1">MLPLWKQVSLLIWKSTLIRKRQKILLLELLLPILLFGILTLVRARNFTEQHRICHYDAKAFPSAGLMPFLQSFLCSFTNPCYRSPTTGDDTSTIDSGLRKQSLAVEVGRIMSEMYATIGSEPVKWNNIWDSVIWLIDLFAHFTPQTFEKPIPFDLFFNSTDDAVKFFKSILNSSEDLSNSLNYIQISPLDAIEIIREGLQSATADKIIVEYDDLLKILGALNSLRNDQVIRKLFSVLSEVDFNNQTSIIDALHCGNDRKFLFIVYFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Y6</accession>
    <name>A0A183H7Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3598</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002463">
        <property type="protein sequence ID" value="VDO37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Y6"/>
    <dbReference type="STRING" id="387005.A0A183H7Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0000359701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000359701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000359701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000359701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42765" checksum="A145014682E6A856" modified="2016-09-07" version="1">MSDLDISDQIASECINGKSLPLFSPTTPVSFYLMDVTVNFIKLTIHHPISLKPEIDMVPGSPLVSPDYIPLSLMSSGNDQWSDKHYLDVLRPIMSLKTDTGSSMLATDADRVVNGSCILQPLISSLHPSPFLWNTLPKFASHPILSREQQQHYHYTYGTFNTLHTFCSKTHTAFNSLMDFSTADRLRLNGNTAIESAAPLFPLPVSMSSESSFLIPLILSHDFSMEFTQPSEIGSSPPHGSLTIVPCTKENLDTFVLMPTPAQRGMAKGQLRNMKMKSGEASEMDKPDETLQKSGPEKDYKELNEAADIVDVSAISNRLSSNDEIELRSPIKKLFKRNDENMDRVLNQMDFEKKFASLPAFTPDDPQKGNYIAYFASILFLLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H888</accession>
    <name>A0A183H888_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrator complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3700</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002568">
        <property type="protein sequence ID" value="VDO37473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H888"/>
    <dbReference type="STRING" id="387005.A0A183H888"/>
    <dbReference type="WBParaSite" id="OFLC_0000369901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000369901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000369901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO37473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000369901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18201" checksum="A68740E8D5A938E1" modified="2016-09-07" version="1">MYLSPSATEKGYVDTFIRALLMSNSSQAITFELLIRKIETYAKRVTDDNMKNDCLALACIAQFRYLGTIYDCKRIFNSIFDCDLESWHCAPRDALIQVLPEILPSHIIQQDAANNLLQMFLRKVHDNLPAFRITILQTLLLLRTDEQTTNKVISELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8L1</accession>
    <name>A0A183H8L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3824</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002690">
        <property type="protein sequence ID" value="VDO37878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8L1"/>
    <dbReference type="WBParaSite" id="OFLC_0000382201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000382201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000382201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000382201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="4852" checksum="CA83E1188AEC1534" modified="2016-09-07" version="1">MSRVRLSVSWCGRLGVAMDEGGCWRGAFLGQDFLVIWSIDGCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9B3</accession>
    <name>A0A183H9B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4075</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002960">
        <property type="protein sequence ID" value="VDO38784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9B3"/>
    <dbReference type="WBParaSite" id="OFLC_0000407401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000407401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000407401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552438" evidence="1">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000407401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23490" checksum="DDF80694704D7F14" modified="2016-09-07" version="1">MCNTIVLSTAPLLLFILLSNFGRDTHAIACLYMGERHNHGDRWVVRSAFIIECNVYPDGSWRADVVACQTPRGIEIHDGDEIVEDDMKLQCKKLPFGAYQIQKHYIIRNIDCEGHSFGEWWISKRNFNKTCTPAGTHIVNCLTDTGIPLRLNTSVTLDGTRYNCAVHSNNFVTLTREFSRNFRIIPKTSPTYCTVNDTRKQIGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9G9</accession>
    <name>A0A183H9G9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diacylglycerol kinase</fullName>
            <shortName evidence="10">DAG kinase</shortName>
            <ecNumber evidence="10">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS4131</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01003023">
        <property type="protein sequence ID" value="VDO39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9G9"/>
    <dbReference type="STRING" id="387005.A0A183H9G9"/>
    <dbReference type="WBParaSite" id="OFLC_0000413001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000413001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000413001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000011">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056392">
        <property type="entry name" value="DGKtheta_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24099">
        <property type="entry name" value="RBD_DGKtheta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ras-associating" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="12">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="11">
        <location>
            <begin position="246"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000413001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="518" mass="59001" checksum="F1DD663D9CADF89C" modified="2016-09-07" version="1">MALRRFHISDNPDCYYITQVLNDNGEEELLEDPLPLRNVRRPEGRRAQIFLRYKDDPEKTVVKLYGGWLRVPVTFCSLLVTKETLVQDAVAEALDHFGLDRNSANRYNLIEVSLDRGVAERTANSQENMLQLVRNLRKDSLRRYHVVRFYLQEKDDPHEHAVFVANLPLSLAQRQYERILLRLLGAKEKPFTAIGPIYFEYGSLVITFNTAKAATSAVQRLQNAVYEEKKLIVLCLPNVQPHMLSPDCEPLLVLVNVKSGGCQGSELIKAFRRLLNPFQVFDVLKGGPLVGLYVFRNVPKYKILACGGDGTIGWVLQCLDIAKQDAACFSPPCGIVPLGTGNDLARVLRWGGGYSGEENPIDILRDVIEAEEIRLDRWAVVFHEEERTQPSTTSSVESSTDAGQMMNNPEDQTSMIIMNNYFGIGIDADVCLQFHNKVRTLPRDANPEKFSSRLFNKTQYVKIGLQKAFFERACKDLWKRVELEVDGKIIELPCIEGIIVLNLLRYRTFLQFFSVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9T0</accession>
    <name>A0A183H9T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4243</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003141">
        <property type="protein sequence ID" value="VDO39393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9T0"/>
    <dbReference type="STRING" id="387005.A0A183H9T0"/>
    <dbReference type="WBParaSite" id="OFLC_0000424101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000424101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000424101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000424101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49526" checksum="21C6ED7D6DD87EEA" modified="2016-09-07" version="1">MTIRASPADEGFINSEWSLIFMLRTGLIGLQLLPDTAQPNIVLITDAVCNVTDIHALQKLVFQLRNYSVACSFIQIQGDCNTNAVFGHFSSPEFFTFLAKGTSGVYIPDENQTTVDGILNPIDCRPLLCKNLQLLDATDDYIKDLIHQINPEFVEPYAFDYFSGVIRRMHYSMEYESCLEYFLRLRLYEGFILRNLKVLKKGEDQSLILVELSLPWKPQVTIGYKICALSEDCTKRTKLKITVICEAQYGMIRDLLSDRCSVNTAKQTFSDAYRHTIFGLLETDRMLIHVHSFNSLPDLFRLSPEILKEKSLFRYVMKENKAILTISTRELETLCSQNVAAANFVEFWRIISESEERYWQSWSQVYTFRVILTHDHPLPPRLFLAEEPNVKVTSQLALTVFYNILTQMTTFSLIHGQTYVKFVEGYVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAF9</accession>
    <name>A0A183HAF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4471</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003406">
        <property type="protein sequence ID" value="VDO40096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAF9"/>
    <dbReference type="STRING" id="387005.A0A183HAF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000447001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000447001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000447001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000447001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33681" checksum="FD33145B9D8B4EC1" modified="2016-09-07" version="1">MTSETCRDASGDDEQFVVVKRRRKKNGRLPRVSYGKSGKIATTICYPMDQVSMERIEMVMKNACSNTELIKYSQQIIALLLKSLSGRQLSSIWALGLGSFSCSHYLGCDQLAVLLELKHYFGCEVYFQEPCLTKMEKHWLCNHAICLSETKDLLECRVSGDDNDNENIVLFYAPHCGHAVYNSVIYAHRKKLKNIIIAGNNLHSMDLTARYSELSPNECTVRECNLKDLKNSDLNELEALLLYSKVCTVLEFPIFKSNFAVFNDTAVHFLLQNSQVPKISEAKPKYRLFRHEIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAJ6</accession>
    <name>A0A183HAJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HYPK_UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003456">
        <property type="protein sequence ID" value="VDO40194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAJ6"/>
    <dbReference type="STRING" id="387005.A0A183HAJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000450701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000450701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000450701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000450701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13048" checksum="7CA576B058F0652D" modified="2016-09-07" version="1">MREKEKDEQNGIEDHTDRVIKDTSKSKDWAAADLEKVTDFNEDSDIGREVSNEKLDSLISGPSGSLRENRKIVNVRKEDVLLIMDELELPKIRAEKKLIEHNGDVIAATKDLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB90</accession>
    <name>A0A183HB90_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS4755</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01003774">
        <property type="protein sequence ID" value="VDO40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB90"/>
    <dbReference type="STRING" id="387005.A0A183HB90"/>
    <dbReference type="WBParaSite" id="OFLC_0000475101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000475101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000475101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000475101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29351" checksum="D74481F627EBE794" modified="2016-09-07" version="1">LHIVPKTRIVKLASPAFYYKDKSRFNNKELKGKDGSYQLFLNGYVSASDIIPRWKKRGGLCPLTAVEVERFKYLFQKLCVLDYVIRNTDRHMGNWLIKYEPEKILELAAIDNGLAFPVKHPETSSRLRQFPFAWAQLSWANYPWNEELRTNLLQLLTPQFVQSLCDDIATLFKYDRDVNRFLKYSQLRVFRGQIWNLRLALIMRESPAEMVKRPQVLVSRRYRHNPPDNDWNRAFRVKSADFSKRACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBD8</accession>
    <name>A0A183HBD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003835">
        <property type="protein sequence ID" value="VDO41091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBD8"/>
    <dbReference type="WBParaSite" id="OFLC_0000479901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000479901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000479901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000479901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="7073" checksum="47E20D2D8225BF2E" modified="2016-09-07" version="1">MQQHRELVPIFGDVMNDNSSAEMHVLDLLLSIHCLILLHEFNHDLLIHFRHFDRRSPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBK4</accession>
    <name>A0A183HBK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4866</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003907">
        <property type="protein sequence ID" value="VDO41300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBK4"/>
    <dbReference type="STRING" id="387005.A0A183HBK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000486501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000486501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000486501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF101">
        <property type="entry name" value="COPINE FAMILY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000486501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33866" checksum="56C02D768E982D2C" modified="2016-09-07" version="1">MGLLEISVMYRDEMNKTGLIGSFLTTYAKMKYGPGEENVYNLINQKKMSKKGYLKSGTMQLIKFCDVSIYSFLDYITSGTQLHLAVAVDFSSELNICNVNDIRTFDVDFECTLRGVVNILRNYNPSKSFPTFGLGARIPPLYNNSDVFHLNFDVEPYCNGIEGILEAYRNARRSVMLSDRAEYLPVVNAVAELAKNAGRPGYHYFVLLVFVSHNSIANPQRLMDAIMDVTKAPISIIFLGSRPTELERFYNHTRFRSEMSADGTTWNSDFAEVSFILRNMILKKKKKHSFNYHLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBR9</accession>
    <name>A0A183HBR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4931</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003995">
        <property type="protein sequence ID" value="VDO41484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBR9"/>
    <dbReference type="WBParaSite" id="OFLC_0000493001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000493001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000493001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000493001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9996" checksum="B5983EE56EB7FF0B" modified="2016-09-07" version="1">MTYFGYNALQDAHEFLIKCKGSATQCYASNIKLRISKNETTEIQSLRIAVTVEFIIRCKNCDVAMRKEEESAILSVSIHMLETSWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC52</accession>
    <name>A0A183HC52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5064</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004163">
        <property type="protein sequence ID" value="VDO41932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC52"/>
    <dbReference type="WBParaSite" id="OFLC_0000506301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000506301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000506301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000506301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6952" checksum="C27560687ADDE5AB" modified="2016-09-07" version="1">MQVKHEIKGDRRAVQYDVSELDLEGISFQSNDVKCVDWPYKYPEYYKANETTHNHDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCR7</accession>
    <name>A0A183HCR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1 family domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004457">
        <property type="protein sequence ID" value="VDO42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCR7"/>
    <dbReference type="STRING" id="387005.A0A183HCR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000527801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000527801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000527801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000527801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42571" checksum="A66617A7E3F86EEF" modified="2016-09-07" version="1">MDSSSRSITDILSEANARILFGALDAIDGPKIITWDPTLIKQFNLVTTTEQLKQHKVVAMLQLDLSPGVPQAEHNHVVYILSAYNLSIINKLITCLKHARSINDSRQHHALIVPEASFMIRDTLKQNREASSILKTLESLSLRLFPLYSDFLTLLMHDLPSKLLLDNDWTELQKCASAVRQLELLVGCLPNLRCKGKWAAQIVEIVKKMRIQMNESQTLSEHNDFQISDIILIDRWIDPLTPLLIQLTYAGLVDEIFDIGATGNIKTSKLSSTSDSADAASEISLHDPLFKMIRDLHIKDVGKEIAKTLGTLRDERTRLKENPPSDSLAESKVFVRRLLDMQGSEKHADTHTLIAERLMSFISDDLRYSTFPKLVIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCY0</accession>
    <name>A0A183HCY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004541">
        <property type="protein sequence ID" value="VDO42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCY0"/>
    <dbReference type="WBParaSite" id="OFLC_0000534101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000534101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000534101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000534101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11200" checksum="140121223E03F605" modified="2016-09-07" version="1">MGLFFRFYLASVGLRHNILSSPKEAGANSICDIGNNIDNSGDNSNERLCTVSTRQYYHNKSAKSITIPYDINHSKRSPTIILQNAHKVLQFSVKSLNMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDM6</accession>
    <name>A0A183HDM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5588</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004876">
        <property type="protein sequence ID" value="VDO43655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDM6"/>
    <dbReference type="STRING" id="387005.A0A183HDM6"/>
    <dbReference type="WBParaSite" id="OFLC_0000558701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000558701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000558701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000130">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="104"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="195"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000558701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33728" checksum="E1C550D7A96B3586" modified="2016-09-07" version="1">MKIQRVPAPQLDYSRNEQQPHVIVGRPITLWCLVSGYPLPTIRWMKDGHLVPINGKSGIRLIEGGQGLEILEAKREHAGIWMCEASNAAGKTDYELNLDVWTLPIVFIHPEDNVRPVDSVITIQCQASGNPEPTLSWSKDDQPLITSAEGVRISLKGTRLDIPRLKQSHVGEYTCTATNEVGTSFATVHIDVLVPPVINRDNIEMSPRLPTAQTLTLICDATGKPLPEIVWYVNDTVIHETMSNVIIGEDGRYLQVNDVSLNDNGSYKCVASNIAGKDELLYTVAIVRKSFLRLNSKFKMFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE12</accession>
    <name>A0A183HE12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spectrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005072">
        <property type="protein sequence ID" value="VDO44104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE12"/>
    <dbReference type="STRING" id="387005.A0A183HE12"/>
    <dbReference type="WBParaSite" id="OFLC_0000572301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000572301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000572301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000572301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39472" checksum="578A5931922504F3" modified="2016-09-07" version="1">KDFEDGLQALDVDVSTVNELFRQIPEPTPSQRANFDHLSGRWEDLWELSRMYVERLKSLEAVLNGLVEVTDIVRRHEIMLNSFDDMPASLDKLRGIHSQLLELNMVLQQQQTIVDALNRNIALLRQHVSRTRQSPNHPDVDRLEDEVQTTTVRWENVCSQVVDRLKTTEHVLQTQIVYRTEYENEIKWLDNVEATINSLRKPEELRPEQYQQQLDQLIAEYSQLQERTEAVENVNREGGQFIREAKGYDNRLMQYMENIINIHGPDIRNSFRRSIPQPKNGAQQVMEELEHLNRRFAQLSSLILERRNIMQILIQNWKRKKQYDFLEDLFATIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE81</accession>
    <name>A0A183HE81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005173">
        <property type="protein sequence ID" value="VDO44365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE81"/>
    <dbReference type="STRING" id="387005.A0A183HE81"/>
    <dbReference type="WBParaSite" id="OFLC_0000579201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000579201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000579201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000579201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10578" checksum="ADDBD73DD12BC0B1" modified="2016-09-07" version="1">VTCGCDKPHESPIYVCQPERISGSFSLAYQQHSLGPSNSSQQQQASSSRESNVQTGTTTLRSRHRSSHHDGLIKCHYCPKKWADQAVVCFLTKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEB7</accession>
    <name>A0A183HEB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5830</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005229">
        <property type="protein sequence ID" value="VDO44489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEB7"/>
    <dbReference type="WBParaSite" id="OFLC_0000582801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000582801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000582801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000582801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13029" checksum="309AC8FDAD5F1914" modified="2016-09-07" version="1">MISMQIISRILLKIFQFICSTFVVYCLYNTGPQWMLALTCLLIPPFGIYLILRLPKQKIRCDKYYRAVERSWLRVEIAVCFTMAVVFSGFGILLFCGFFKVFFSLICLEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEI6</accession>
    <name>A0A183HEI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5901</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005328">
        <property type="protein sequence ID" value="VDO44736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEI6"/>
    <dbReference type="STRING" id="387005.A0A183HEI6"/>
    <dbReference type="WBParaSite" id="OFLC_0000589701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000589701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000589701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO44736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000589701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36457" checksum="DE6E4E91C48A945B" modified="2016-09-07" version="1">MERKRGWLEKELEMLYAVMQQQNPVQPLKIANEAENSALKREESLLKPVSTALTTQITDAEKSPKFNIIAVSPKRSSLSSSPSSSVSLKSDSNFKKKRTNRNKDALAKDDLLIGVASLLSCAVCPGEVTLRDQDGIKEHFINQHLDGEHGRCRACTEEVKSGDVLSHMKAHLVKEYACEFCGKKGRKHYLKAHIRIHTGERPYKCEQCSRRFADSSTYRRHQMIHTGEKRYSCPVCGRCIARKDNVKTHLRSHVKTIFNSESEAAAWMETLLNSLPTKTERNALTVPPLDSPTSVENNEDQNLLGDFNLLESLKEEDEMSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEW8</accession>
    <name>A0A183HEW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemagglutinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005504">
        <property type="protein sequence ID" value="VDO45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000602901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000602901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000602901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000602901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12676" checksum="2B9BF4AA6E547FA6" modified="2016-09-07" version="1">MSVDRTIEELSYTLAQLGNLVGHINSQIGQLASRINLTLDTFDQSIAGIAIDAEIMSNHVTNTISQVPNGWLFYLLLLTIIVVFSLLSITLILGTIKRSFDIYELFKKLSTSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFR8</accession>
    <name>A0A183HFR8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridylate synthase RPUSD4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA pseudouridylate synthase domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6329</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005960">
        <property type="protein sequence ID" value="VDO46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFR8"/>
    <dbReference type="STRING" id="387005.A0A183HFR8"/>
    <dbReference type="WBParaSite" id="OFLC_0000632901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000632901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000632901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF83">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="8">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000632901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28936" checksum="10526BF6742F7715" modified="2016-09-07" version="1">MGLKKIWEEIQPVWKMSDEDLVNLMADRIIYEDEELIAFDKPYQMAYSNAPSNQAELLRILPKLSSRVTPHIDCLRMIKSIAKPVTGVILFAKNKSTQEKIKALYDNRLLEQYYRVITNMAPVHKEASINIPLFKCRRKNNNFMMLPLGVNKNNEINPFLEASTHYRVLKHDPKNHTSYMECIVNRDVPEQIRAHLGIGILCPIIGDMKYNCSRREAGRGIPPRLSDIALQDLNITGNLIYLPLLCTVGMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG57</accession>
    <name>A0A183HG57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tubulin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006160">
        <property type="protein sequence ID" value="VDO46635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG57"/>
    <dbReference type="STRING" id="387005.A0A183HG57"/>
    <dbReference type="WBParaSite" id="OFLC_0000646801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000646801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000646801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000646801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17351" checksum="EB5080234C1CEF2E" modified="2016-09-07" version="1">MLLVNVPVPTSFQQLKIVNGVTHATFCSACQAFNLLENDQHWNICIYDACNMSHPNQIRTLSAIILTACSPSSPIELWEKYKSHMAEDILHRIRSENSNLNMDFTVEIYNEALIMIEDLCLQIAKKVLDQLGMSSPNRSASASFDIKLHREQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGT9</accession>
    <name>A0A183HGT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006533">
        <property type="protein sequence ID" value="VDO47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGT9"/>
    <dbReference type="STRING" id="387005.A0A183HGT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000670001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000670001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000670001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000670001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27130" checksum="AC17698815942AA8" modified="2016-09-07" version="1">MEKISDDGMQEWPDSDRLKEALSLAKFDHYYTMPGLKTTITLPDLMANMLQQKLDKTVVRPSVPKDMNGVHLLIADGHLRAAVNLTAELLTKINQGFGMAGQPSSNTEYSLKVWACRFQLLMALKLYTLLNDELIPFEELDAPDLFYQYYPNLYSKSCKGSLVLFSMRLIHAEALRFTSNPWATLVRIDRLEKNVNKVLNNSVSRSEHFFEIWKDRLLAVQKMRARSLYFLKVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGV3</accession>
    <name>A0A183HGV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006556">
        <property type="protein sequence ID" value="VDO47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000671401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000671401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000671401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000671401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14374" checksum="C0C241C023C50F83" modified="2016-09-07" version="1">MTSKTWHLLQQKHLAIPHKMARFFGSKVPDPIDPGRSRTLHSDAAKLTIFRNITEPRQFLATLWRSCFLDDRKREYIVVASLNSVKSIFSCCFGGWLRSHRQPVIPGFCRVIDDFFAELLIIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHM7</accession>
    <name>A0A183HHM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6990</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007004">
        <property type="protein sequence ID" value="VDO48761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHM7"/>
    <dbReference type="STRING" id="387005.A0A183HHM7"/>
    <dbReference type="WBParaSite" id="OFLC_0000698801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000698801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000698801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO48761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000698801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41706" checksum="4DF3241B408BD215" modified="2016-09-07" version="1">MQISSLFSLTVATMFSPIVSPMADNTTLKMRKATQTIKLDAAGMRVISGFFADFCFQLDYITSCIKRTAGLHFVHCIRPLSAVDMHMRPDELLNIQFVRNQLRCFSLVNSARAASQGFPEQIPYKYFRCRFQCLLKEQNISSEYMDDRAYSGKILKELGAFSHRYRLGLSQVLLRSDLLDELEELREFCLSGLIEHFQQICRKYLAMKWLAKRRVQEIAIRCIQRNGRAYGKVREWPWWRLYVRVSPLLAATRSDRENREWEQKLDEKENKIQELRIAKNRLEARIVELEQMLAVERGNAQSMNDALEREVEHRLQTEKQVLVLQQRFHDSKEDSRMSSSCSSHSRLDQSVYVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHN0</accession>
    <name>A0A183HHN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6993</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007010">
        <property type="protein sequence ID" value="VDO48783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHN0"/>
    <dbReference type="STRING" id="387005.A0A183HHN0"/>
    <dbReference type="WBParaSite" id="OFLC_0000699101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000699101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000699101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000699101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32514" checksum="E706ECAAFFA53D25" modified="2016-09-07" version="1">MSNKELTEEASSVAVFRTRKSVKRNATSRRKSISETSDSSNDAKDENKVVKCVDGRKRRKNPMIQSTASRKIQKASESTSSNSSSSSGEEESIQNDPLSVTFASSGTAERAGPSDMGATAVNEIDTDVQSDAQAQFERVQQILKEERDDKVYRGAALYGAKEKKDTVWGNASSGLNRFGPIRAPNFLRQSVRWDFAPDICKDYKETGFCTFGVYIAFDSISSNSCKFLHDRTDYKHGWEIERDYAAGRMKENDEDKYRISSEDEEEEESELPFKCFICRQSFVNPIITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIJ9</accession>
    <name>A0A183HIJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007539">
        <property type="protein sequence ID" value="VDO50347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIJ9"/>
    <dbReference type="STRING" id="387005.A0A183HIJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000731001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000731001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000731001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000731001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21772" checksum="F2B46D37A5F7C334" modified="2016-09-07" version="1">MNKETKKAIDGCNIAPSDCVSILHRSKQKFSIEVLSLGDEKSIDNSNRSFPISSFSIPSVAGNTQYYVQLLWGEEAQRRRLKRFENEKCANFTFNGYTFTKCKFLNEEQCKSTASEDACYGFFDRDAFELGLRVTLISVVDNRLGIITRNSYLPQEKMLTESVILEPNATMSPTANKSVVEDVSMISTASRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIS7</accession>
    <name>A0A183HIS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7389</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007693">
        <property type="protein sequence ID" value="VDO50773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIS7"/>
    <dbReference type="STRING" id="387005.A0A183HIS7"/>
    <dbReference type="WBParaSite" id="OFLC_0000738801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000738801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000738801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000738801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28541" checksum="CB61BAB35C20D923" modified="2016-09-07" version="1">MVNYEFAEFLQQLANVVNILSEGQATRRGIAIISLSSQEALVNALKLNGMELQGRSLRISLRDQSRPSFSSGRISFQNHQPRPLFGNDNIGPNNAYGHYKNSGSYHEGGYSTLPHPRRGPLPAAYHAYNSDSRPNRIPLQNCSSYRGRDNRRYDYDNRLFRHPKPGNNQFLPRFTVRPGRSRTESIRSNTTDGTEKHERRKLQLQPRTKPLHNTGEDLPARPTSIFGLAKPVDTYEKEKQRIQVVLRDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIX0</accession>
    <name>A0A183HIX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7431</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007761">
        <property type="protein sequence ID" value="VDO50978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIX0"/>
    <dbReference type="STRING" id="387005.A0A183HIX0"/>
    <dbReference type="WBParaSite" id="OFLC_0000743101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000743101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000743101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000743101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26674" checksum="2D2663AA3CEC2B14" modified="2016-09-07" version="1">MHLTKPGRAYELTWENRWSLLAREFAMIEADIFCLQEVQYDHYDQFFKPYFEAAGYFGKYKKRTRRLVDGCAIFYKSHFRLLHYRCIEYFVNNDSVLDRDNVGQLVRLKDMRSGREFCIANTHLLFNKRRGDVKLAQLAVLFANIDKECGPESGQECPYILCGDFNIQPYSPMYNFIMSGEICFTNLRRGDISGQGNPGGPFVSVNILPEDVKIARNCQFKYLKSKCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJY9</accession>
    <name>A0A183HJY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008377">
        <property type="protein sequence ID" value="VDO52547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJY9"/>
    <dbReference type="WBParaSite" id="OFLC_0000780001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000780001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000780001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000780001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="2950" checksum="F8BD00AA15342D3E" modified="2016-09-07" version="1">MEIKGTEGTGEGVVGQMSSDQHCATNIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK90</accession>
    <name>A0A183HK90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clu domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7901</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008555">
        <property type="protein sequence ID" value="VDO53065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK90"/>
    <dbReference type="STRING" id="387005.A0A183HK90"/>
    <dbReference type="WBParaSite" id="OFLC_0000790101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000790101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000790101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000790101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14478" checksum="F35B8C35AC58A85E" modified="2016-09-07" version="1">MAVVDGNVVAINPADEPRTHMYIWNNIFFSLGFDVKDHYKELGGDAAAHAATSNDLQGVKAYAQLDNSKLFTLGMVIVDYKGYRVTAQSIIPGILEREQEQSVVYGSVDFGKTVVSSEVILFFKCDLQNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKN1</accession>
    <name>A0A183HKN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008807">
        <property type="protein sequence ID" value="VDO53753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKN1"/>
    <dbReference type="STRING" id="387005.A0A183HKN1"/>
    <dbReference type="WBParaSite" id="OFLC_0000804201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000804201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000804201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000804201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9907" checksum="542A557E72E82AE6" modified="2016-09-07" version="1">MEENTRNGGMASDIHLAQQQKKEYGALCMKQYEVKQSKDNENDEGINENFKTVVAMIVDDDIRKTYILCKEVRLINPEELINTIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKR8</accession>
    <name>A0A183HKR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8078</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008865">
        <property type="protein sequence ID" value="VDO53936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKR8"/>
    <dbReference type="WBParaSite" id="OFLC_0000807901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000807901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000807901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000807901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13844" checksum="CDCD83772CF997D2" modified="2016-09-07" version="1">MNLAVSPEHLNALKKFYAFSGDSPVDLSSVTRNLMHLVFCHKKSYASRGGFPVNIGLAPRNFMHFLVDILADAEPRSRFYESIMNCSKAGNGNGPNYWNMLSVICGLRGNGYGLVRGGLGGSVNFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKZ0</accession>
    <name>A0A183HKZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8154</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009000">
        <property type="protein sequence ID" value="VDO54277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKZ0"/>
    <dbReference type="STRING" id="387005.A0A183HKZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000815101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000815101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000815101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000815101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7517" checksum="E4A13B910B43630A" modified="2016-09-07" version="1">MREGKTPTAAAEITVRAISRKYPNFFGAIVAVNKMGHFGAACHGMDSFKFCMQNQNFKKVKVMSVTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLC7</accession>
    <name>A0A183HLC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OMPdecase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8285</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009236">
        <property type="protein sequence ID" value="VDO54947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLC7"/>
    <dbReference type="STRING" id="387005.A0A183HLC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000828801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000828801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000828801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO54947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000828801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11926" checksum="F96257E74DF574EC" modified="2016-09-07" version="1">MKGMIRLAEAALELAKSNRDIVSGFICQKRCADIPDFLYWTAGVHMDAMSDGIGQNWRTIDNAIDVDGNDIVVVGRAITGVTDINTQIRRYRDAAWESFINRQQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMN0</accession>
    <name>A0A183HMN0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS8743</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010127">
        <property type="protein sequence ID" value="VDO57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMN0"/>
    <dbReference type="STRING" id="387005.A0A183HMN0"/>
    <dbReference type="WBParaSite" id="OFLC_0000874101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000874101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000874101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0401">Integrin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000874101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17804" checksum="8DC8716F3A5F9BAD" modified="2016-09-07" version="1">MDLSYSMKDDKQKLSELGDLLAERMKAITKNFRLGFGSFIDKKLMPFVDPRPEKQLSPCPEQCAQPYGFKNQMSLTMDTARFSKEVDEAEISGNLDAPEGGFDAVLQALTCNDSIGWRERARKMIVFSTDAGFHYAGDGRVLYISYYFHKCADCANIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMT5</accession>
    <name>A0A183HMT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8796</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010244">
        <property type="protein sequence ID" value="VDO57450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMT5"/>
    <dbReference type="STRING" id="387005.A0A183HMT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000879601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000879601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000879601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000879601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14068" checksum="1D282CE67E6E5661" modified="2016-09-07" version="1">MENSKLWWKQTSSRVRYYSSRELQTFHEVDALLCRGELRCAYLRRNRASSIEQIPLEKIFRLNLQLVSECPGNIVIGRHVSVFIGLLVVLVQLRKVPLNFMAFKSEFLCSIYGDRQKFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN47</accession>
    <name>A0A183HN47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8911</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010465">
        <property type="protein sequence ID" value="VDO57979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN47"/>
    <dbReference type="STRING" id="387005.A0A183HN47"/>
    <dbReference type="WBParaSite" id="OFLC_0000890801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000890801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000890801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000890801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29080" checksum="83A1DF8F17A26A0C" modified="2016-09-07" version="1">YHCKCIDPWLTKIRKVCPICKRKVLSSGESDSSDSENEGRDSTSASGSTTVYRENAPLLRNAEAFASGSPSASNQRVEGRRNMHDGQRPPLRVIITSPAGTSLPAPGTGYLIATDGETRETSSTTTISSRFEAVSETLRRTLRPYYQQIVNRSRRVPWRNAPREPECAPAPNTQRPFVVDNNAFDQSSEALNIAQSSSVADRRDLEAVGVFPSEGIAVTERSHPVTAASSGTTGFESGSVPEVELPIDNQQNNLFLIIKGMKSGHSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP92</accession>
    <name>A0A183HP92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9309</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011275">
        <property type="protein sequence ID" value="VDO59626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP92"/>
    <dbReference type="STRING" id="387005.A0A183HP92"/>
    <dbReference type="WBParaSite" id="OFLC_0000930301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000930301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000930301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000930301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23678" checksum="8E892378E726AE12" modified="2016-09-07" version="1">MKIIPLKFFLGNYSFNENRKENETLLKDLGAFNILEEVQQEITDLGNTHAEYEETVPSDDISENQDSEFAQKVENELDSVYMRGEAGLRQFRQSGEIASLEERTRSKAQSSNSVNIKKINITGFEGQYAELPKKNHSLTYPSELLIYSFPKGDLSDYPPPPRDEVGTPGWWLLDGGSVAPVLALGLTEESNILDMCAAPGGKSLLIVQSDLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPH5</accession>
    <name>A0A183HPH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nef protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9385</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011445">
        <property type="protein sequence ID" value="VDO60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPH5"/>
    <dbReference type="STRING" id="387005.A0A183HPH5"/>
    <dbReference type="WBParaSite" id="OFLC_0000938601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000938601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000938601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000938601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4310" checksum="34E48320FAC6C4F3" modified="2016-09-07" version="1">MALSFSRDEVTWLLRHVDIWPVSSSKKTKYADEVADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ14</accession>
    <name>A0A183HQ14_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hyaluronidase</fullName>
            <ecNumber evidence="3">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9577</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01011886">
        <property type="protein sequence ID" value="VDO61597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ14"/>
    <dbReference type="STRING" id="387005.A0A183HQ14"/>
    <dbReference type="WBParaSite" id="OFLC_0000957501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000957501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000957501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO61597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000957501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23632" checksum="745940C39C252FF3" modified="2016-09-07" version="1">EYWYKFNFWIIANNNFFRLQLYIRKFLIATIREAKKMRPNASWGFYGMPFCNYSAGKSDSAGCGRVYKKFNDRIAPLYTEVDAFYPSIYLPHRGSNITSYLYVTSVLQEAERCAKKVNPKMPIFAYTGIEYFPLNFSNPFYSKKDLHNSLSQAYHMGLQGAIIWSTSKNMMERCDGIKNYVVRYLGPEIANLANITSPKTASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQP4</accession>
    <name>A0A183HQP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9807</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012446">
        <property type="protein sequence ID" value="VDO63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQP4"/>
    <dbReference type="STRING" id="387005.A0A183HQP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000980501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000980501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000980501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000980501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="18725" checksum="E8A99A64171B00A1" modified="2016-09-07" version="1">PPLPTTPTEIPVTEIPGYVPTPPTTYAPTPSIPGYVFIPGIPSVSATPGYLPAPVTPGYVPAPSAPGYIPAPSAPEYVLIPGAPGYAIAPSAPGYVYLSGAPGYLSALPSYIMPPNIFIEINCHWTEWYQWSSCEKTCHHHMKYRFRECIGGNNCTCSGDAREEMSCLLPPECNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRN2</accession>
    <name>A0A183HRN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10141</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013227">
        <property type="protein sequence ID" value="VDO66181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRN2"/>
    <dbReference type="WBParaSite" id="OFLC_0001014301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001014301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001014301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001014301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8331" checksum="63162DBE6AD2281E" modified="2016-09-07" version="1">MQKDYKAALESHQKAESLEPGFSNENTLSLGKAELALGRKKDACESFKKAKILTPRYRNEYKVFLSHLQSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRV4</accession>
    <name>A0A183HRV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013372">
        <property type="protein sequence ID" value="VDO66742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRV4"/>
    <dbReference type="STRING" id="387005.A0A183HRV4"/>
    <dbReference type="WBParaSite" id="OFLC_0001021501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001021501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001021501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001021501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11683" checksum="32BD9E2916F01598" modified="2016-09-07" version="1">MFKIGVKYCIAGEMDLNLGGSKKKQHHVRKKYSIITLDLFKPTKKSYPEFDYEKICKEYLKEDESSGEDERFHDREAEELVKRLEQKYVCLVIAFSPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRY6</accession>
    <name>A0A183HRY6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS10247</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01013444">
        <property type="protein sequence ID" value="VDO67010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRY6"/>
    <dbReference type="STRING" id="387005.A0A183HRY6"/>
    <dbReference type="WBParaSite" id="OFLC_0001024701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001024701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001024701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (D/K/N)" evidence="13">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO67010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001024701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16399" checksum="09B5434391D9255F" modified="2016-09-07" version="1">MPDSNDPKYSNSYDMFMRDLNDQYMRFLIFVTTTALDGLNVALPVRTYVILLMHHLIALALITILCEEILSGAQRIHDASLLTERAKHHQIDLEKIRAYIDSFKYGCPPHAGGGIGLERVTMLFLGLGNVRLASLFPRDPKRITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV33</accession>
    <name>A0A183HV33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prefoldin subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11342</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016288">
        <property type="protein sequence ID" value="VDO75785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV33"/>
    <dbReference type="STRING" id="387005.A0A183HV33"/>
    <dbReference type="WBParaSite" id="OFLC_0001134501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001134501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001134501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO75785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001134501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10397" checksum="4B02BD36932E4038" modified="2016-09-07" version="1">MELTHLLNDHVYQRVKTDSLDKVLLWLGSNVMVEFSLDEARCILEDNYKTEDGVTKYEKELAFLKDQITTTEVNMAHVYNYGIRQKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVB5</accession>
    <name>A0A183HVB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016491">
        <property type="protein sequence ID" value="VDO76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVB5"/>
    <dbReference type="STRING" id="387005.A0A183HVB5"/>
    <dbReference type="WBParaSite" id="OFLC_0001142701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001142701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001142701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001142701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16101" checksum="C4832EF4F1B457AB" modified="2016-09-07" version="1">MEIVIEFCLHSFFAEFKSLWRNASVDHLDEKKIEEYLQKHGIDVMKDLGPKKLTVAPPKRKLPRRRANQKVHNEHLTDVLEDYSICKILTAIPVPTLDYEKSRIVTESRNLQSLKTGNAPNCLPFGDLWYPIAINEIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVQ6</accession>
    <name>A0A183HVQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016853">
        <property type="protein sequence ID" value="VDO77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVQ6"/>
    <dbReference type="STRING" id="387005.A0A183HVQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001156801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001156801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001156801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001156801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17149" checksum="E6EB787415C4EC71" modified="2016-09-07" version="1">MEHDRMKLNDGNIIVYPEIHNPATTSDSSDNNMEFKKEMDIYNRNSALNKNNSQIKLGKVEARVFLRETKPKSHYAEELQRPQISSDSESRMLVVGEDPRLYYTDSECITSASNSKHFQKHKKPIHYAIPYYARVSKTPVFCLKIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVU7</accession>
    <name>A0A183HVU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016995">
        <property type="protein sequence ID" value="VDO77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVU7"/>
    <dbReference type="STRING" id="387005.A0A183HVU7"/>
    <dbReference type="WBParaSite" id="OFLC_0001160901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001160901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001160901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001160901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11241" checksum="04601BA8553CCF72" modified="2016-09-07" version="1">AVNTGASIVGSRHSPHRQTVTKKTRVYVVDGVQMTSTSHQVFGVKQDYELSHIPRYHISLYGDWSVFQFTIYLIFVRFSVDIVIVIVLDNDTHRRMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWD2</accession>
    <name>A0A183HWD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MPHOSPH9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017541">
        <property type="protein sequence ID" value="VDO79340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWD2"/>
    <dbReference type="WBParaSite" id="OFLC_0001179401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001179401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001179401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001179401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="11723" checksum="0E67AF98416D6080" modified="2016-09-07" version="1">MGSPVPFTLNSPLTTPRSTPVPTVSSALGTPVSGVRVPSRGPLTDEEYSNIVQNVITASSGSVGSADQALLKEVLVSNQFLNYFNENSRSPHNGTFPLQNSSDARSDSSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWH6</accession>
    <name>A0A183HWH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rieske domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017632">
        <property type="protein sequence ID" value="VDO79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWH6"/>
    <dbReference type="STRING" id="387005.A0A183HWH6"/>
    <dbReference type="WBParaSite" id="OFLC_0001183801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001183801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001183801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001183801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10687" checksum="A3AA1F75E9D86CA6" modified="2016-09-07" version="1">NCSGEFSELSCPRKDQWVGGIEYIDHPRQPLILQCCTFHGLRFSQEVGLTNVGPGEAITGGEVIRDGRQISFDVIANVRKVVDVNTHMLVYILMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWM9</accession>
    <name>A0A183HWM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oxidored_molyb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11888</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017769">
        <property type="protein sequence ID" value="VDO80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWM9"/>
    <dbReference type="STRING" id="387005.A0A183HWM9"/>
    <dbReference type="WBParaSite" id="OFLC_0001189101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001189101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001189101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001189101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10299" checksum="6D3B6BBB55A43905" modified="2016-09-07" version="1">MDSLIDAKNHRLKVEGISVRQPLILSLDDLKREFACVSVNATLQCAGNRRSEMDAMKKVQGLNWKNTAIGNAKWSGARLKVYILLSSNFHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX32</accession>
    <name>A0A183HX32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved oligomeric Golgi complex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018195">
        <property type="protein sequence ID" value="VDO81435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX32"/>
    <dbReference type="STRING" id="387005.A0A183HX32"/>
    <dbReference type="WBParaSite" id="OFLC_0001204401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001204401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001204401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001204401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9473" checksum="3A1C6B974802BD4A" modified="2016-09-07" version="1">MEAEVQKFLESNSVSPDFSGVDLKLQNYQKTFSSQVQESINNLASVKSIADEADRLKDLEEAVKEMKMDVINLEEQISQCWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXG4</accession>
    <name>A0A183HXG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12179</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018568">
        <property type="protein sequence ID" value="VDO82560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXG4"/>
    <dbReference type="STRING" id="387005.A0A183HXG4"/>
    <dbReference type="WBParaSite" id="OFLC_0001217601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001217601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001217601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001217601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16275" checksum="B710DC99F980BD82" modified="2016-09-07" version="1">MEDKTPLSPKSPQIPENSFEPQVPEDNGLLDGIEEPMKVRKISMDFSNGDKNFAENFLEEKTETPGKQFDPLNSVLSSQDTPLLDSTPMTPSAPSVISADVIQNSSDASSPSKESHDYGSVSKAATHNQELMHKESLQGIFDLMNFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYK0</accession>
    <name>A0A183HYK0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisome assembly protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12562</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039867">
        <property type="protein sequence ID" value="VDP11609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYK0"/>
    <dbReference type="STRING" id="387005.A0A183HYK0"/>
    <dbReference type="WBParaSite" id="OFLC_0001256301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001256301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001256301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001256301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19749" checksum="AEECB6330BB71F81" modified="2016-09-07" version="1">MTLHLSAKQTKGVKFYSYCQLHCYYCFVPEFKLVIIDKWDFRRSWRTLAVFASLLTQCITFGLYIIQFLDFYYNSDTGENFRTEQRIRNWKYPSAPHKKLHENSVLLLETNKCPLCLQQRINDTVLAVSGYVFCYGCIYSFVEQKKKCPVTSLPANVDDLIKIFVHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ84</accession>
    <name>A0A183HZ84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12796</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039936">
        <property type="protein sequence ID" value="VDP12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ84"/>
    <dbReference type="STRING" id="387005.A0A183HZ84"/>
    <dbReference type="WBParaSite" id="OFLC_0001279701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001279701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001279701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001279701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11443" checksum="C3310E586D7A5926" modified="2016-09-07" version="1">MSVYTPRNVLVTGGCGFIGSNFVNYIFQVWPQTNIVNIDKLILNSDAHYVNEEVIESSRYKFITTDIRNCALIERILNENKAIHLKFNFAGQIYRVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZE0</accession>
    <name>A0A183HZE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039954">
        <property type="protein sequence ID" value="VDP12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZE0"/>
    <dbReference type="WBParaSite" id="OFLC_0001285301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001285301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001285301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001285301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7763" checksum="9DFF8C1DB635D8DA" modified="2016-09-07" version="1">MKRNGSIPDYIGVACLSLLGYYAVNDPVFGSLMFGSLIQCLGPGVLQSEYCLVMFSSKLLIHCKFRPLCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZW8</accession>
    <name>A0A183HZW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13030</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040018">
        <property type="protein sequence ID" value="VDP12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZW8"/>
    <dbReference type="STRING" id="387005.A0A183HZW8"/>
    <dbReference type="WBParaSite" id="OFLC_0001303101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001303101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001303101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF282">
        <property type="entry name" value="CUTICLE COLLAGEN SQT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001303101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="36604" checksum="8E95CA80EC1F9517" modified="2016-09-07" version="1">MKVHQATFLASAISGVSLIVCLLAILMIYTDVQKTWNQLDFEIITFRATTDDLWNDMIELARKKRFRRQYDDRNENDNGIRNDSATISYQSETTTTATATNGYENEAWFDQYGSETINDPSGDNECRIDNKCPAGPPGPKGPPGHKGEDGLPGKDGKPGADALDLKQNKSTTGCFRCPMGPQGPPGALGRPGSRGLSGNRGRAGLPGRSGSPGLPGEPGPPGPRGPDGPAGPPGVKGEDAEQPVGRPGLKGEPGLPGPSGPPGMSGRHAMPGPSGPPGPPGNLGPRGPQGPSGPYGEVGPRGLPGKDAEVIILVFVNNLKVFSSMRFRIYVYLTRSSLQNTYIAMEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I032</accession>
    <name>A0A183I032_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alkaline ceramidase</fullName>
            <ecNumber evidence="9">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13094</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01040043">
        <property type="protein sequence ID" value="VDP12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I032"/>
    <dbReference type="STRING" id="387005.A0A183I032"/>
    <dbReference type="WBParaSite" id="OFLC_0001309501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001309501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001309501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001309501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31448" checksum="AB61377FF211F7CA" modified="2016-09-07" version="1">MRMDRWFDYESGHAWCESAYKYQIVSVIAEFANTVTNIPFIILPNVSVLLIRPYIETVNWIIILPHILLTLTGIASTYYHATLNLFGQLIDEISILWLLMMCWVTYFPVCTFYPQQFQKYVGRVRCVIVLMTVVASTFCFLEPSLNALILMFFSIPCIPFIHHEAANAGIPEIISFPRNISTLWIVASICWVSDRMFCSFWLFLGIPYFHALFHLLSSLAVYYVFIMFSLIDICRHSDEHQYKCRVKYFPEKGLIRLPYIALNLDCRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0A2</accession>
    <name>A0A183I0A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TBPIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13164</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040069">
        <property type="protein sequence ID" value="VDP13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0A2"/>
    <dbReference type="STRING" id="387005.A0A183I0A2"/>
    <dbReference type="WBParaSite" id="OFLC_0001316501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001316501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001316501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001316501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24471" checksum="F96A431614F4BD4F" modified="2016-09-07" version="1">MRSNRMSSNVSTGSKGQPDEVAVGIICNYMLQQNRPYSAIDVWNNLRQEYSKAQIIKCLDIGVERGILREKLISKQKIYFVDQSKIEKCGEEELQIMNESIIAKNNRLSELNNEIKIIKNELKEYENALSIEEMIALHTTLEAQIMKMEERVSSMATYAKNEVVDEKKKSELVAKLESYQRQYKERKRIVDRIVDAICENISISRKKLMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0I1</accession>
    <name>A0A183I0I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13243</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040106">
        <property type="protein sequence ID" value="VDP13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0I1"/>
    <dbReference type="STRING" id="387005.A0A183I0I1"/>
    <dbReference type="WBParaSite" id="OFLC_0001324401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001324401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001324401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001324401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9852" checksum="C23734270C32E8E4" modified="2016-09-07" version="1">MNVFRIAGDSSHLIAIAILIVNIWRTRSCAGLSGKSQLLYAFVFTSRYLDLIYFISIYNTIMKMIVKAIIMANKWITFFFMMLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1Q2</accession>
    <name>A0A183I1Q2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13664</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01040322">
        <property type="protein sequence ID" value="VDP14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1Q2"/>
    <dbReference type="STRING" id="387005.A0A183I1Q2"/>
    <dbReference type="WBParaSite" id="OFLC_0001366501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001366501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001366501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="45"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001366501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="627" mass="71037" checksum="C4856FAF707AB575" modified="2016-09-07" version="1">MSHRFAIRIAHQDISSQPYSITVESQKTGKILLFQSSAVTTICMVLRLFSSGSFYYASQDDASRCIDLTSNYFNSLLFRNKHLHYPLKRYKIDANEWLLRIICGSVVICQVYVGQQRATIALISRLSYERVGTRFNVRGVDDDGHVANFVETEQIITLGTDEISFVQIRGSVPLFWEQPGINVGSHKVKLRAFEASSPAFNRHFRALKEEYGEVIVVNLLGSKEGETLLSKAYEAHYRNSRYVADYITFDYHEEKRNCMKLMDRLKPQIIKCINQNGIIRVNCLDCLDRTNAVQTLIGFQVLAVQLESLKVDKKYFSRFEEHLKDIWQRNGDSCSVIYAGTGALEGKSKMKDAKRTLVRAIQNNFLDTSKQEAFEFLLHGTFICDSSYSELASMIPQYPSVVKDLAERKMEMVENVPLTVWVGTWNVNGGKNFSDIAFRNQTNLADWLFPQHFPELAGENANMPDIYVVGLEEIIDLNASNIVNASTTNQRAWALGLREVLSKRNKYILLGCEQLVGVCIFVFIKPSLATSVRDMSINSVKTGMGGATGNKGSVAMSLTIYSTTFCFVCSHLAAGQNEVRDRNEDYMNALRKIKFSQLLQVDFMKLGFRNFFLKKSFLNIGMKTVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1U1</accession>
    <name>A0A183I1U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF4206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13703</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040348">
        <property type="protein sequence ID" value="VDP14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1U1"/>
    <dbReference type="STRING" id="387005.A0A183I1U1"/>
    <dbReference type="WBParaSite" id="OFLC_0001370401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001370401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001370401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="6">
        <location>
            <begin position="236"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001370401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="52958" checksum="8A37F92BA41C7324" modified="2016-09-07" version="1">MRRAKIRCPDIRSRMAQAQDVTHSDESETDGLDIDGKVKDILDATVNNEKDSTGQNNFADTEIDNLINREISEIIIREKRNKNEMTRYAELELAIAHCKKRLRKIGDNERSIERVQLMEKLVQCQLELDALKEESSDPAKKIRLSRAVIVKGHQFSLQSATGRNPYCEVCLYTIWRLIQRYRRYCGLRSHDKPRTEICEERGLDLQNYECAECHHSLQFGELETYCFGGATDSEPRLCDYNGYYYCPRCHWNDEWFIPARIVHNWDFCKYKVCRATKQLLVIIERRPIFNILKLNPGLVNYIDQLAKINKLRRNILLMKCYFMCCKVARKQRILQNLRHRQHFVENSDMYSLIDLVDLYQGRLLPDIERIIRIYTEHITKNCLICKGKGFICELCNDSAVIFPFSENVAICHNCLATFHQECFNRKSKHCPRCLRRKSRAHSVFLVDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1Z3</accession>
    <name>A0A183I1Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13755</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040376">
        <property type="protein sequence ID" value="VDP14574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1Z3"/>
    <dbReference type="WBParaSite" id="OFLC_0001375601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001375601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001375601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001375601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9119" checksum="CD5B18704C3F0C5A" modified="2016-09-07" version="1">MEQLSEFNAGGGKRREMGMQFEWTCIDQKLQVKLIRATSSEPSKATSTQLYALCFMPQRFRSFLTHFWSSSPFIFWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Y6</accession>
    <name>A0A183I2Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040596">
        <property type="protein sequence ID" value="VDP15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0001410601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001410601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001410601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001410601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14326" checksum="F1D4B8C799CCEE8A" modified="2016-09-07" version="1">MGHAGTIISSSSENAAAKLKVMKSARIEIAETPAVIGKKILEAMQKGYRTFICTNHVGNAHHVAKHRASVSRWSREVIHQDAIARTRLNFCNPITTPSLAVPPSYSPSESGGNVVTGFAIPSAPVPIPDICRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3H4</accession>
    <name>A0A183I3H4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14286</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040739">
        <property type="protein sequence ID" value="VDP16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3H4"/>
    <dbReference type="STRING" id="387005.A0A183I3H4"/>
    <dbReference type="WBParaSite" id="OFLC_0001429401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001429401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001429401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000019">
        <property type="entry name" value="60 kDa heat shock mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001429401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46821" checksum="B5E439F3740B0FDE" modified="2016-09-07" version="1">MAWDSKRLHNAEIPSVCISLVGKAPASVRKVKREGRRGERREKKEAVTKKERNRERRHVLSASSRTFYAAHRALPSFCKSCELLPRIVAPPSLKYTIQVSTTGQPVSSPPPTHLFRKYFCHFIGLLIHKVEAKMFRIGGQSMARLVSRTVRSGLRHYAKDVKFGADGRASMLYGVDTLADAVAVTMGPKGRNVVIEQSWGSPKITKDGVTVAKAIDFKDKYKNLGAKLVQDVANKTNEEAGDGTTCATVLARAIAKEGFENISKGANPVEVRRGVMNAVELLVTELKKMSKDVTTPEEIAQVATISANGDSSVGKLISEAMKTVGNKGVITVKDGKTLHDELETIEGMKFDRGYISPYFINTSKGAKVEFEKCLLLFSEKKISQVQDIVPALELANKYRKPLVIIAEDVDGEALTTLVLNRLKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I438</accession>
    <name>A0A183I438_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14500</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040906">
        <property type="protein sequence ID" value="VDP17333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I438"/>
    <dbReference type="WBParaSite" id="OFLC_0001450801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001450801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001450801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001450801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12198" checksum="A13EFFEA0A47E9D5" modified="2016-09-07" version="1">MTNHMGSVVFLLCKPPYVLEGNPFVVCGSDGEWRPLLGTCKLPQKSVNYCQPYVYNTSTSLHYNSVLKKIPLGTTIILECPYGQRIQGNSSSKCVKGKWQPTLGNCVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4A6</accession>
    <name>A0A183I4A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14568</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040966">
        <property type="protein sequence ID" value="VDP17664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4A6"/>
    <dbReference type="WBParaSite" id="OFLC_0001457601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001457601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001457601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001457601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10692" checksum="53F05AAE7AD747A2" modified="2016-09-07" version="1">MNIVLSLITSTKTGTRSVRNGTNTARGKQSKRRKNGIFHSGTWPRKHMLFKMGIAVSALSTLLLFIELKIDLPSSLLTLAVDCGFAAFVGRIAVRMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4M5</accession>
    <name>A0A183I4M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14687</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041086">
        <property type="protein sequence ID" value="VDP18246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4M5"/>
    <dbReference type="STRING" id="387005.A0A183I4M5"/>
    <dbReference type="WBParaSite" id="OFLC_0001469801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001469801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001469801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552770" evidence="9">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP18246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001469801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32838" checksum="03B1CFEF52941DE9" modified="2016-09-07" version="1">MKYLACLLALTVTGLIAWTLGSFADQELWKSSWPQCPIQAWCLVWQGYESLFLIYGMRLCYKARNSKWLEWWQFTIAVYSEAIVTLLANFLRNPNSTFFISRYSIRYWAHSDTLMTITFVQLHLTVSINIVIIIAPKFYLVRSGGTRRTQTLSGTGNKAHPSLAKLRDNLLNGTIDFAEVPIVDMNPEDIRAELKRVYTQLRMYKLKNLYQDNPHISRRKGGKKLSSDKVIIKNRRTSISTSNSPKVKRIDEDERNDLTVESAPHNVFLSTYKLQLEPHQSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5I7</accession>
    <name>A0A183I5I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041467">
        <property type="protein sequence ID" value="VDP19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5I7"/>
    <dbReference type="STRING" id="387005.A0A183I5I7"/>
    <dbReference type="WBParaSite" id="OFLC_0001501001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001501001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001501001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001501001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="30182" checksum="1A2444816A53E654" modified="2016-09-07" version="1">MSARNSSSVVNGNINIETPLKFGLSSSTLAPSFSFGKAPEINSLPTVNEEQPTVLSSHPPNATLAFGVSSGSSDTAASIIPSLTHSSFSFPTLTMTTSSATTVPSPGNTFSIPISTSVNPFTFGSSSTTTADGIKAPTASLFSFGSAAPFPAVTTNASAVTTATPLPSFGTTLPDFSASKTPLFGSSGGSQQMPVAPKPFEPPASLTSPPSTFNFGATASNGATGFVFGSTAPPTNFTFGAQQPMNNAVSTTFNFTPASSAPPFGNVPGSAPTPNFFSVGSTSSTTARKMLKARRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5R9</accession>
    <name>A0A183I5R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041579">
        <property type="protein sequence ID" value="VDP20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5R9"/>
    <dbReference type="WBParaSite" id="OFLC_0001509201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001509201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001509201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001509201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11095" checksum="0886F0D7E8A84921" modified="2016-09-07" version="1">MILTTMVLGNVLGNGNDSGNKPRHPSSEGTIDQVWTKIKRIVEMVYDKIFGAIAEFFDDQRSNTWKLFGKTNYTVMPLSRNPIDRCRVAIYINIGNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6D6</accession>
    <name>A0A183I6D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15298</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041910">
        <property type="protein sequence ID" value="VDP21231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6D6"/>
    <dbReference type="WBParaSite" id="OFLC_0001530901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001530901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001530901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001530901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6890" checksum="E6E8CAEFFC45FB9C" modified="2016-09-07" version="1">MVIDKFPDIELNSLRLLGGSSITGVNYQVGMESHFVAGPVYILIGLRKHGYNERDSPEKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6F3</accession>
    <name>A0A183I6F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15315</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041941">
        <property type="protein sequence ID" value="VDP21304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6F3"/>
    <dbReference type="STRING" id="387005.A0A183I6F3"/>
    <dbReference type="WBParaSite" id="OFLC_0001532601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001532601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001532601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001532601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13821" checksum="34D2B8F8927A3165" modified="2016-09-07" version="1">MNGASDENIENRIGEENEENEQFLRQKVQRKRRPHALAYRDTNISGAISKECELLQERSIYVSISGKSLLEKRRKHEICQQRYQEPPTKNRWLPTGTSAFTVFCDDDNDQGSSKDFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7V4</accession>
    <name>A0A183I7V4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15816</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042954">
        <property type="protein sequence ID" value="VDP24075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7V4"/>
    <dbReference type="STRING" id="387005.A0A183I7V4"/>
    <dbReference type="WBParaSite" id="OFLC_0001582901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001582901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001582901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000034">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527:SF8">
        <property type="entry name" value="TUBULIN BETA-4B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP24075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001582901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7304" checksum="669A52F406CF4A5A" modified="2016-09-07" version="1">MREIVHIQAGQCGNQIGSKFWEVISDEHGIDQLGQYHGDSELQLERINVYYNEVQKKRYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UE03</accession>
    <name>A0A3P7UE03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000741">
        <property type="protein sequence ID" value="VDO29909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H229"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="443" mass="50682" checksum="718CD1B29AB7A11B" modified="2026-01-28" version="1">MAENEAKARKKLEDAEKKAKGGTGFFSGLFGNAKAEEAADLFVQEDSETVLVCEENGCGMGFDDVVTFEDHYERFHRHQCAICGQQFPNIHCLEIHADENHCSIFKTKRDRNPSLALFRCYEASCSQAHTNPEERNFHSEEVHGIRDPTLFMKRRKLPRKEFVVARMNELSTACITHSRTPRVVIFGSEQKEPTFETRRRKNDEQEAGDAFVRSAEIHAAATDQKHDAASNYAEAANCYRKVNPQQAIDCLMKTAETYTDMGRFNMAAKYHCTMAEIFESEAPDMAQAMAHYQEAADFYKGEESRSSATKCMIKVAQYAAQLEDYKRAIKIFEEVATWEADHPTLKYAAKNHFFQALLCHLCSDLLDTQNALKRYEEISPSFVDSREYKLINELISCLEDKNQVKFTEVVKAFDKISRLDQWHTSLLVKIKRSCGDEDDDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UJE8</accession>
    <name>A0A3P7UJE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001930">
        <property type="protein sequence ID" value="VDO35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5828618at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="257" mass="28630" checksum="56BCE66AECCB11A4" modified="2026-01-28" version="1">MTTPSSNAYLNPFTNANFYSSAYPIDLSHQNQSNHYCFGENVQSNVTTDTVEMEINVEHGIAFEQKNCAGLQIGNLKNNYRKRRSLCENDAPLCKRRMEKVSARLENFHISGDPGSSVLDSKDSDSDDTGEEDIEKDDALLILDERLRKYIEQEFKTPPITIDNSLSMAVVPYVSPISYDNPAMIGRIKEIDAEDAVEYVSNDNGLVTFPDDTHTKESENCSNEMITQSADSTFSIINIAEIDAVVQDSADMEIDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V4X9</accession>
    <name>A0A3P7V4X9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease, ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004396">
        <property type="protein sequence ID" value="VDO42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V4X9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="103"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="4">
        <location>
            <begin position="319"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46156" checksum="953512A99367D51C" modified="2019-02-13" version="1">MNKYIIGQEQAKKTLSVGVYQHYLRLYHNIENNISSPAINNMEGNRSRTAVSSAGVLYQEDYSRSGRADIRFFSEGSAPQQKHRIVSPVFRPLPENDAPIRLEKSNILLLGPSGVGKTFITQTLARILDVPIALCDCTSMTQAGYVGEDVESVVQKLVQNAGGNIERAQQGIVFLDEIDKIAAAHNVQSHAFRDVSGEGVQHALLKLVEGTLVNVKSSRKSMSTQQDFVQVDTTDILFVASGAFTALDRIVGKRLDKKTLGLGARSGMQRITDDDKLETAIAKKRDDLLRQADQGDLISFGIVPELVGRFPVIVPFHSLDKGMLIRVLTEPSNSLLAQKKLEFAMDGADLSFSSDALDEIAALALERKTGARALRSIVEKVLLEAKFMVPGSDIESVHINRECVKGKADYVYTRRAQQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WLL4</accession>
    <name>A0A3P7WLL4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SARAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004944">
        <property type="protein sequence ID" value="VDO43793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WLL4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SARAH" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="81" mass="9984" checksum="7E5449EC1DE8BBA6" modified="2019-02-13" version="1">MVTDIPDWLRLYSRAPYELDHLLEWPLFRLSQLEQYDNQLMKLYKQEGIDIAIKYERFRREINREIARRHQKFMASANALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XID3</accession>
    <name>A0A3P7XID3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000596">
        <property type="protein sequence ID" value="VDO29082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1F2"/>
    <dbReference type="OrthoDB" id="8921675at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019344">
        <property type="entry name" value="F1F0-ATPsyn_F_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10206">
        <property type="entry name" value="WRW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="165" mass="20087" checksum="F93E9D2BE7B2707F" modified="2026-01-28" version="1">MATKIPVTKYFRPFVPPLSPGTKIHNDLYWDVYLYRPYCRLWERVWVYLYNRVISRFEIGVQDKEYNPRVHGPYCPWRYYGTKRDTKLMDVKLCDLRSWFSRRDKSIGGIANGAVKSFYRFEHYYFDHYLINLPRFFLRFVLFAYLLGTILFYGEIPASAAKYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XUN0</accession>
    <name>A0A3P7XUN0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011976">
        <property type="protein sequence ID" value="VDO61924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XUN0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO61924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="160" mass="18432" checksum="AF768A2FC97E3A88" modified="2019-02-13" version="1">MEVIAKRLREEKRKNVAEKCDEKEEEPILIRGLHHFPFQFELPQSSMPCSLETKLGTIRYYVKVIINIPHGTVPQGIKYFTIIGPSTDCMDEKYCCALLGQNKEIKWHGCCRRGALALRVIMDRTAYLCGENVRILAHVENRQGGIVWIAMRLIQVLLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XY91</accession>
    <name>A0A3P7XY91_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS11842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01017636">
        <property type="protein sequence ID" value="VDO79651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XY91"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO79651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="135" mass="15142" checksum="1268904757AD7C4A" modified="2019-02-13" version="1">MKYNIQICQLFKICRISISLSSFRCIFPGKFCLEPRGRDGGLVSDTYLEIDRNSGKLSLIKSAEKPILIHDAEVKIIHGIVGIIKLVSGNALIVITKANLKGVLTGHEIWAITETEIIPYEKTTLHLTEKQVIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BV94</accession>
    <name>A0A3P8BV94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040070">
        <property type="protein sequence ID" value="VDP13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="80" mass="9293" checksum="49B8C56DB8A62A35" modified="2026-01-28" version="1">MRRNNNYKHRESIVFVLSLHLPFITTAKRPILKPGERGHLPTGTVTTNIKTTFTNTTSHIHMVPCDTKNRVQKKPMKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BVY9</accession>
    <name>A0A3P8BVY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040126">
        <property type="protein sequence ID" value="VDP13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0M6"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="112" mass="12281" checksum="06E5CC4D70C5C86E" modified="2026-01-28" version="1">MAVKKQKKSTENINARLAMVMKSGKYCLGYKQTLKTLRAGKAKLVIIANNTPPLRKSEIEYYAMLAKTGVHHYNGNNIELGTACGKLFRVCTLSITDAGDSDIIRSMPSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EW73</accession>
    <name>A0A3P8EW73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040158">
        <property type="protein sequence ID" value="VDP13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0U0"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="105" mass="11873" checksum="3ED0E192ABE05512" modified="2026-01-28" version="1">MDHGSEGVGPDSLATIRQQVESVKTVMNNNMQRVLERGEQLENIEDRTEALTQLSQNFQWTAQRVQRRMCVKNAKWTIIIIACVMVIVAAIILIVLNNFGVFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EY60</accession>
    <name>A0A3P8EY60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039943">
        <property type="protein sequence ID" value="VDP12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZA0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="459" mass="52541" checksum="25C47553E69281DD" modified="2026-01-28" version="1">MKGRKETSNVPVSCSRVPISHLSIRYGILCATPWSWRCKLYCNGAKCKYCTWKPWSLKEQAIRGLYSSWVTENIVAMSRPTAKTFTDDNLVAQFQKANIRAVINLQMLGEHDSCGPKLLPSGFTYNPEILMQNGIQFYNFVWPDFGTLGIDILLDIVKIVHCSLRQGKVAIHCHAGLGRTGVVIAAYMIWAEHFTYAEAISRVRTARPNSVQSKKQIRLVMDFEMFLEKNGAALPKTGTMYLKDYMHLQMKILSSNQARKYHHIPKVLHVAMEELLYVVHGELDGRTRRWITDILKCTSRIDLEFVEKWPARLPVPSKAKSQELDICICGVMENYGEILDSGDKDATIIKDGTFKMNNCTKFIRTNFRGKMLLLFRVLDQLMNSFVKPIIPKEELLGNLRRNDEHTDWQCLNRYLLVTMASLSNGNYRNIAKLISCWYLGESATDDDIIVALQNRLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYU6</accession>
    <name>A0A183GYU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS406</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000129">
        <property type="protein sequence ID" value="VDO25674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYU6"/>
    <dbReference type="STRING" id="387005.A0A183GYU6"/>
    <dbReference type="WBParaSite" id="OFLC_0000040501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000040501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000040501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF6">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO25674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000040501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44411" checksum="7043415D74A75F21" modified="2016-09-07" version="1">MAINFSKSTSGLMQHSIYGSRHLQFRQVLGKFIDKSINPYVDEWEAQKHFPAHSLFKKLGSLGIFGVNKPAGYGGLGLDFSYSIAIAEELGRINCAAIPMAIAVQSDMATPALSTYGSDYLKREFLRATLEGDLVACLGVSEASAGSDVAAIRTTARWHGSDLIISGSKQWITNGTQADWICLLANTNDNLSPHRNKSLICVPLNEPGVHRSNRIEKLGMHSSDTAEIYFDNVRVPSRNIIGEEGQGFVYQMQQFQDERLIAVAVLLEPMQKIIDMTIAYTRQRRIFDKSVLDNQCVHYRLAELQTDIEAVRSLLYRAVMERLLGKDVTMLASMGKLKASRLARAVTDSCIQFWGGNGYDWNNLISRYYRDFRLFSIAGGCDEVMLRIISKLMNMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZR1</accession>
    <name>A0A183GZR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hormone-sensitive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS721</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000268">
        <property type="protein sequence ID" value="VDO26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZR1"/>
    <dbReference type="STRING" id="387005.A0A183GZR1"/>
    <dbReference type="WBParaSite" id="OFLC_0000072001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000072001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000072001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="359"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="792"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000072001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="890" mass="99226" checksum="6F017C724ED8F101" modified="2016-09-07" version="1">MNIRKSNAFGSHLDGIEMSYKAPLCGKLSVQRSAVFALLAELADDNRRFFKNTTSWITYASRLEKNCLAVATLTLPLEVLLFAEVVKKLQDMAPRYDYDKLTPGNGFRSLVCICDMIVLHLISVLRSCTEYRQTMMFRASYYCKEVESYCAVLNFLVSALRLVIDTAVYAPDNCLFPDLNGDYSKHQAMLGVIEMLDPSCFYGRPLGFQFPPSIGRICRLLGVMLAIYSLSWEKGCSTLGSFLNSPRFILSPEQRAKRIVKVTREADIEFCRSFWNLSEFGSHVPRIFCPNMAINELREISWVGSITMATADGGTVKIPEPSSYTGPRPVKIRVLSYYHRQVLSPAGLPNQLPPSPYLLLHCHGGGYVATTSKSHETYLRVWAKLLNCCIVSVEYSLAPENPFPRPTEEVLYAYAYIINNAAQLGWTGEKICMIGDSAGGNLIMSVSLKLVQLGVKRIPDGIVTVYTPFLFQCLLSPSRLLSCMDPLLHMGVVLRCIAVYCETYFLSAYTGKPINHTANGDRYERKDVDNGGHKSLQEYVKQVQKTQRGDAVGLEGSSSIVSLVNLSGIASTAEIHNISTVAKAENEQEFSNETNVGERDEDEGDTCLSGVQIKSDSFHIHLSSNMYDQRLVDYLKIHPLTKDALILMDHTGYIESRKEKKEVMNVEENRRSSRVSKFAALFCSPSTTIPKELPPETLASVRSSMRSRFMLTSLSSYNIVTKNESLAHKRTLRQSLADTATVAVGHALDNISDWFEKSTPMPPIDKIKLDRAASLPSIITSQTGKKIRKKIPRDPLISPIYASPEDLAQLPPVWFVACHLDPLLDDTITFAKKMRDAGGRVMSVDLLDNLPHGFLNFTLVSPECHEGAKICLDRVKEAFGITDTSPTSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1I8</accession>
    <name>A0A183H1I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1348</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000616">
        <property type="protein sequence ID" value="VDO29199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1I8"/>
    <dbReference type="WBParaSite" id="OFLC_0000134701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000134701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000134701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO29199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000134701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="629" mass="72009" checksum="306EF556A473D184" modified="2016-09-07" version="1">MQLTREYLPAQRYCIKVSAEELVMGEAEFGDETLFCSHFGFVAMRSNEPTNNKEEVEEAIMQKDEKKKNDSDDKKDKEKRRDSVTGSTLDTSSSSNSSVDSDEIDITEHNDSKSTMTSEESKLQVDSHEVDDSVNEVMKRISIISNMESGEISKSITELNNGKKNEQIMDVHIDANEWNGLFFMDANIGFTKTQFRNKQDIPSYQNDIFSSKGDLSQTVDEDAKRDTLEALKDSVMDTCPKLGAWIIRKEIMSIDGMETSNLLYMTDISNKFAQRFTYWIRKFYIAAVDGDVEEFMIKFTCILQVLKNNAGNEHYKRMSGHQLKEHVMNSVICTFFNKSENTSILHHLAPTKYTDRPCSMRNHGCCRLMKIILSMLPWNNRKILLATSTKRTGKTALHLAAATGQPCQMQALMDFGAWPDFFDHSGRAPIHYAIMRNNLEMVKLLLWYGADISLRERSATPLQLAGYSPTTTSICEYLYARVTALEKVFMQWIRKYVRGVWTPVHAISDLHFARLSKACDSRRDASRNFTTKNRKVHINISETRTANPQLKKCPLMLLFIVPTFYKEEDRMADASNPQIFCAKLQNVNGFIVRLLPTRPLLSCSKWSIGIKSALEKPHNGYFYVYKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1L8</accession>
    <name>A0A183H1L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AP3B1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1378</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000635">
        <property type="protein sequence ID" value="VDO29317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1L8"/>
    <dbReference type="STRING" id="387005.A0A183H1L8"/>
    <dbReference type="WBParaSite" id="OFLC_0000137701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000137701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000137701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056314">
        <property type="entry name" value="AP3B1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029390">
        <property type="entry name" value="AP3B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24080">
        <property type="entry name" value="AP3B1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit beta C-terminal" evidence="10">
        <location>
            <begin position="311"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO29317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000137701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63334" checksum="0FB238E20647E5E2" modified="2016-09-07" version="1">MTEMADAAVEAIGQCAVRVSSVADSCLSGLVSLIASSNENVVSAAVVVLKRLLHTNPPLQLLTRVLRLIDSVKASQARACVIWLVATHVDKVPTLAPDVLRKMAKNFTHEDEIVKLQTMNLAAKLWFTNRQECELLVRYVLQLARFDQSYDIRDRCRFLRNLLFSDNKLSIFANEIFITEKPSPTTQSTFKDREQFQLGSLSHFLNQRCRRYRDLPQFPETAPDSSMRNISQMEEISNDMQDSHETEDDESEEEDFYSDDEELSQKEEESDEEDEDESNEEENETEDEDKEKNKGDESEENGVLTTSEPKTSGNLDLLLDLNFELTPILANNYAVEPKSVKTPFMPLMNHAVWSTGIGIDICFPRETSLMSSSMCAVLFRFTNSLETKSSEITASQKIKDQMSTNDQIKVGKLSPGESIIKKTYIDFGDSKRASEWVIKAEDTSEVTVTIEAPMGEQIEPITMTEEQFINGILRLSGMNEHCGNLKQPLRPEELYAVANCTNVTGSEVHFCAQTLSKKQQVLIALESKQVHVHCENIVLGSLLCNDIVKKSLEKTLETSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H267</accession>
    <name>A0A183H267_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spatacsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1577</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000773">
        <property type="protein sequence ID" value="VDO30043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H267"/>
    <dbReference type="STRING" id="387005.A0A183H267"/>
    <dbReference type="WBParaSite" id="OFLC_0000157601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000157601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000157601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000157601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="66577" checksum="E266F6F11328E465" modified="2016-09-07" version="1">MVVKYSLLMCRSARCLLIVRRHLLSKKFALNEEWCARHRALSELGIEGGYEWITAVQKKFVSAGIASAVDVDAAVCIAEESDQLDDVLKIIYKLRHIEMTGRMLPSTEYALIRLLLKHHKTDILLAILADPINYGIFLNEHSACLVIDNFLEADRITDAARIASFIMLQEMFQSALLNWLCIYSSLRWTELPTEQRIFEKLPSLDYIAGVESDSGNMEDEDEMTFKFPYLKNEYNDMHFDLTDPNQLIGKCLLWFSNCVPLNEEEASNIRLIGYVFYGNYVLAKQLLQTMNILSSAAVICCSRLEQVTVKTNDIEQQQDEQLSGNAIEELKKIFGKVEKKNANDKLSDIIMKHLKAIQGTEEKNLIEIQRSVFFNWIENRANLIKAQVEQLDLKLRLKETYEERQKLRHRWEMLNFFENRLKWEDMAAVKEELLKTEQGKRKSKEDLEQEYVDEVFHKKGVTSYIFLKQSGRIVWKEMIENLAERLSESAHIADHDPSLALYRLHEHVGKTLPALVIRKHTMANLNSRLQGACFDLDNVLLTVQSMKKATTSFENIQAMLRDCIHHKQQLDCSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Q0</accession>
    <name>A0A183H2Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000889">
        <property type="protein sequence ID" value="VDO30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Q0"/>
    <dbReference type="STRING" id="387005.A0A183H2Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0000175901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000175901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000175901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17102">
        <property type="entry name" value="FERM_F1_FRMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000175901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27506" checksum="321EF7AC4EE232FA" modified="2016-09-07" version="1">MPANETTAIPTSFIGRISARTSLISTRDYKTTVQLLDDNETICQEFKKTSNAQIILDYICECLNIVEKDYFGLRYQDFNRHRYWMDLNKQIYKQVRGPNVILRFRVRFYPSDVNVLKEEITRYMLFVQLQRDLLHGRLYCPQNEAAVLGALALQSIIGDYDAEERPKNYVAEYKLLLKQTEKLEEKIAESHKLFKGLTPAEAEMEFLKRASKLDTYGFDPYTVMVNVLKELLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3G5</accession>
    <name>A0A183H3G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2025</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001088">
        <property type="protein sequence ID" value="VDO31616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3G5"/>
    <dbReference type="WBParaSite" id="OFLC_0000202401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000202401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000202401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000202401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9403" checksum="3261E209D6D132BC" modified="2016-09-07" version="1">MAISKDATSDEDELQPIYSYSSGMFDYFDPTTQSFNDKRGEKEVETKASKFAIFHIVDDLSLSDCQICHCQFSYGVNLKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3N8</accession>
    <name>A0A183H3N8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA (Cytosine(38)-C(5))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2098</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001140">
        <property type="protein sequence ID" value="VDO31866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3N8"/>
    <dbReference type="STRING" id="387005.A0A183H3N8"/>
    <dbReference type="WBParaSite" id="OFLC_0000209701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000209701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000209701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000209701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41067" checksum="A2E380A0FEDA0DB7" modified="2016-09-07" version="1">MFGKQQSTSFLCAKIDSNDKPMKCLEFFAGIGGFHYALKEIGLQVIIRALDINTVTNAIYKHNFPNTEIQQCNIEKLRTDYYDDYNADIWTLSPPCQPFTKKGLRKDLADRRCIALKSICNVLKTMKHRPRYIIVENVCGFETSEAHQMLKDTLMNLCYSFEEYIISPTEIGIPNSRPRYYLLANLTSHCITVPATSKIIEIWPTDNGTIFRRKAIGEYLCDKANEDISLAILPEKVERFGNVMSFVIPDSLHSSCFTKSYYRYIAGTGPILLQFSNIIQDRELSSEQLRNFALHDNCKNLMHCQIRYFSWREIANLLGFPRTFEKPPNISTKQMYHALGNSISVSGVALLIQHLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3V5</accession>
    <name>A0A183H3V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2165</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001187">
        <property type="protein sequence ID" value="VDO32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3V5"/>
    <dbReference type="STRING" id="387005.A0A183H3V5"/>
    <dbReference type="WBParaSite" id="OFLC_0000216401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000216401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000216401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000216401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="50397" checksum="17B1491E08220ADB" modified="2016-09-07" version="1">MVKSRLPNKPTTELRSIVVDGSNIAMTYGRKEIFSCRGIRECVQFFRNRGHTDIIVFVPQFRRETARSDCPITDQHILFELENENILVWTPSRRINGRRIVCHDDRYILKTAEEKDAVIVSNDEYRDLIKENPQYRRLVDQRLLMYSFVDGRFMPPDDPLGKYGPKLAQFLMKGNQQSQSQVCPYARRCTYGNKCKYYHPERPNGIHISVTDRLMEEKQRRQFLSTYTSQPTAISRDHPTIARTQNLDKLISEKMRIQDGKKLMWIPPNYYQKEMTQPLLPSRPSQLSVSTVQQTTTPFLQNLPLSLDWTHQIRNHHCSSLSNHSLKMMSLKPSLSLTPIIRCNPLARYNRTTIPAVYSPYPYIGLTYPNGISPSKTTYPETVNERHRLQNVLCQLFPKQIVLTVMEAFPDEKDPQKLCPLIIAELQKDHVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4I4</accession>
    <name>A0A183H4I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001371">
        <property type="protein sequence ID" value="VDO32856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4I4"/>
    <dbReference type="WBParaSite" id="OFLC_0000239301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000239301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000239301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000239301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12354" checksum="A8FA80F4DB27B950" modified="2016-09-07" version="1">MRFYHTITRFNDLRTLCSNVIKDANIAITETVILSTKNQASPIYVNHRPISHLTIPSGILIDTFIAPLRWRRVSRDERHHRHWINLRSPWVMDDFGTLVSTGFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5A5</accession>
    <name>A0A183H5A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoyl-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2664</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001581">
        <property type="protein sequence ID" value="VDO33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5A5"/>
    <dbReference type="STRING" id="387005.A0A183H5A5"/>
    <dbReference type="WBParaSite" id="OFLC_0000266401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000266401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000266401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000266401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12083" checksum="EA5C0AE7E3779783" modified="2016-09-07" version="1">MSFYDFYYDAGTLLSVIPGIAIVTEVMLLIDSLSPSVSKTGGKIVKWHKKEQDKVEVGDIIIEIETDKAIMELEFIDRGVLAKILVSEGVSGVPVNQPIATEKEGRLECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6I8</accession>
    <name>A0A183H6I8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3101</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001970">
        <property type="protein sequence ID" value="VDO35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6I8"/>
    <dbReference type="STRING" id="387005.A0A183H6I8"/>
    <dbReference type="WBParaSite" id="OFLC_0000309901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000309901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000309901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099631">
        <property type="term" value="C:postsynaptic endocytic zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000309901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17452" checksum="0B550B754F59D88D" modified="2016-09-07" version="1">MSDPVAEFLAREQNVLAGIQDDSLGTSPLPYVNNIGSNDAADNGNDIASVNEARVLSGTSDSGLDLPALANGVQHSSTTPVLVNLNPKKPSLATLNNISKPEPEKIKKWREEQKIMLEKKDKNEEKKKEEMRAAGKKELEEWYAQRAEKLKKTRVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6N4</accession>
    <name>A0A183H6N4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HotDog ACOT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3146</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002015">
        <property type="protein sequence ID" value="VDO35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6N4"/>
    <dbReference type="STRING" id="387005.A0A183H6N4"/>
    <dbReference type="WBParaSite" id="OFLC_0000314501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000314501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000314501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000314501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12882" checksum="8C3648738C8F4FA6" modified="2016-09-07" version="1">MLHDIFKKTIQSGSKKDHNRILPPNHAWIYDAHLDDTIICYPIKRNIYGKIFGGFLMRKAMELAWSNASLFSGNRCRLCGVDDIMFRKSVDVGSILLLSSQHCMCNIFDRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6V9</accession>
    <name>A0A183H6V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002088">
        <property type="protein sequence ID" value="VDO35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6V9"/>
    <dbReference type="WBParaSite" id="OFLC_0000322001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000322001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000322001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000322001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15013" checksum="5C347C8E714AA7D8" modified="2016-09-07" version="1">MIVNIRTNTYLRSFKLDLLKKLTRHAKKSGFNSGQTATTQLLESVRPNNIQSTCSLSPVVKEQIAIFFRLIDPIGFELGLVMREETGCLVLLLVLVVFFLRSMQRVMQRNVEMHHLLKLHVTRKRDVFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H818</accession>
    <name>A0A183H818_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3628</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002496">
        <property type="protein sequence ID" value="VDO37210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H818"/>
    <dbReference type="STRING" id="387005.A0A183H818"/>
    <dbReference type="WBParaSite" id="OFLC_0000362901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000362901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000362901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF4">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000362901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45635" checksum="24F55870D85182BD" modified="2016-09-07" version="1">MATYYLSVITTALLHFTKPFHGFDVPCTQKLIGGKCLFDEDCYGMNSVCREQRCTCPTNFEEFDIDGQTTVCRLAPNKIGDSCQRDCKPPLLCRDGKCECWGGSIINGECVVPCPSGQQLYGVECQRVAHWGQSCEKDNQCVDVFNACITGICQCAPGTTRDVIKQRCFALCPDGSQPQQACRRLFINDIDMLENAASTDSCPLGYRCVAYGSPYVGHCCKLKCPYGEADLMQSCDMGVSEKHRCRPLTHHCYTVSEPGWKTSLCCPKPCRDPTPLYVNNQCLSIGHREDPCQLHQQCEGGVAMNCVMGLCQCKDGFHPSNDGRFPTCEKSCGINEVAVMDKCMRRVQLGERCVTSKQCPNFSECRFGTCQCLCGYKQDSLIGSRCTNPDDPFSLNAILTGVEQVFGGKTRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H835</accession>
    <name>A0A183H835_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS3646</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002517">
        <property type="protein sequence ID" value="VDO37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H835"/>
    <dbReference type="STRING" id="387005.A0A183H835"/>
    <dbReference type="WBParaSite" id="OFLC_0000364601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000364601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000364601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000364601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19990" checksum="DB4185D88AA9E25C" modified="2016-09-07" version="1">MASKLPKIAPKTVINRTQTPIMVWIRDKLNAVYRDRTTPPPGLPTLDGESKFYEMNRFPNTQAARSRPSASLPGGVHHKSSDNYYLDRDARRSVQPPKCIYSTDSHGPVFKSLDGEIISCEAGTKVEAGLRKNFGLEAPTPGFGYAWHRNKEDELTTQKYSKDFAVLEKYDKFTYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8K5</accession>
    <name>A0A183H8K5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3817</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01002682">
        <property type="protein sequence ID" value="VDO37849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8K5"/>
    <dbReference type="STRING" id="387005.A0A183H8K5"/>
    <dbReference type="WBParaSite" id="OFLC_0000381601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000381601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000381601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000061">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO37849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000381601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51608" checksum="7FF578AA1B86A945" modified="2016-09-07" version="1">MALRKKVLDVVTECFKRHGGVTIDTPVFELRNILMGKYGEEGGKLIYDLSDQGGELLSLRYDLTVPFARYLAMNKTVMYLKRYHIGKVYRRDNPSRGRFREFYQCDFDIAGSYDLMIPEAELLRIISEILNALDVGTFEIKVNHRLLLDGMFAVCGIPKKYFKAVCSSIDKLDKLPWEDVRNELCTDKHIHSDVVNKLETYVRLREHDNSLTNFDLLNWFEKDETTSKNNDIQKAVSEMKQLLEYCEIFGILSTVTIEPSLARGLDYYTGAIFEVTLKGTFEKTSMENGNADEEIQTVNIGSVAGGGRYDNLVSMFLPKHKVPCVGISIGIERLFTIMKEKSMIEHMRSKDTQILVVSAQKKLVKERMKICRLLWDNNIKAEMALKANPKMLDQMQYCEEHKIPLAVIVGERELEEGILKLRDVPSRTEQDIPRDDLVEELNRRLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H941</accession>
    <name>A0A183H941_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002884">
        <property type="protein sequence ID" value="VDO38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H941"/>
    <dbReference type="STRING" id="387005.A0A183H941"/>
    <dbReference type="WBParaSite" id="OFLC_0000400201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000400201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000400201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000400201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11327" checksum="021E788294AD8269" modified="2016-09-07" version="1">MLRVPFLASLDYNLNKRDRDWISHQLPKMQVIYQFKCSAFKESIEIPREHLPDPETENLPSSVSFRQESTAELEKRWTDTGIDRIFVNRPRPPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9G3</accession>
    <name>A0A183H9G3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4125</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01003017">
        <property type="protein sequence ID" value="VDO38986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9G3"/>
    <dbReference type="STRING" id="387005.A0A183H9G3"/>
    <dbReference type="WBParaSite" id="OFLC_0000412401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000412401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000412401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="5">
        <location>
            <begin position="53"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO38986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000412401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23531" checksum="477F73BB83683EED" modified="2016-09-07" version="1">MVGGTVSLTEPVTITNEDRELYSAARNLAELDFDARPSGCTSGEHVTFNDANDSSRNPKAIRIGNFEIETWYSAPYPAEYAQLSILYLCEFCMKYMKSLEMRQRHSERCQLRHPPGNEIYRKDDISIFEVQNFLIILYEKGEFVKLIVDGYCSRIYCQNICLLAKLFLDHKTLYYDVEPFLFYVVTRNDSSGCHFVGYFSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAA2</accession>
    <name>A0A183HAA2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="6">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4414</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01003339">
        <property type="protein sequence ID" value="VDO39929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAA2"/>
    <dbReference type="STRING" id="387005.A0A183HAA2"/>
    <dbReference type="WBParaSite" id="OFLC_0000441301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000441301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000441301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002655">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000441301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36651" checksum="BAC460DC6B11A5A9" modified="2016-09-07" version="1">MVYKEEYTLLTDTLQNNLECVPSADIVLALVAVDVWSTGCIFGEMIRGSVLFPGSDHIDQWTKIVEQLGTPSPMFMRRLQSTVRNYVENRPHFPGFPFDKLFPNELFPASSSSDSRLTVDIWSIGCIFGELIRGRVLFPGTDHIDQWSKIIEQLGTPGRDFMQKLQATVRSYVENRPRHPGLPFEILFSDNIFPKPATNNALCPAQARDLLSKMLVIDPEKRISVDEALKHPYVYVWFDEAEVYAPPPEQYNHSIDSRDHTVEQWKELIFKEIMYYEQTHDEYGIKKSLNCTSAAVPSSSSSFQSSEHSDCSTTGSTLVTNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAQ1</accession>
    <name>A0A183HAQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003518">
        <property type="protein sequence ID" value="VDO40344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAQ1"/>
    <dbReference type="STRING" id="387005.A0A183HAQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000456201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000456201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000456201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000456201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22216" checksum="C0AAF12FF9DBAFD7" modified="2016-09-07" version="1">MEDLTKGRKAPKRRRIAVSQNQQLIGTSQSKIKSETSSIASCNSSEAASPSTSLSGMEVNRNVQNDVAVPSAPSATSVAIDSDNAETVPKEVASISGCSDIRVDSSSQVERKPSVITTTSNRSPTSQLLVDDVSGNSELQHSMNTDETDWQINNGRKRVAERSAEDGEVEPTQSKRCSLVEANPVSPSSIETEQNSRSLFNSAFNGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBC1</accession>
    <name>A0A183HBC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S4 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4781</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003804">
        <property type="protein sequence ID" value="VDO41017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBC1"/>
    <dbReference type="STRING" id="387005.A0A183HBC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000478201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000478201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000478201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000478201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24801" checksum="599F1559036BDDDD" modified="2016-09-07" version="1">MTAINPKSRKRKHEEIDVLDEMPENIGFHIKNGIRYLNPYWSVYRTWAKGRWIGRRLIDVFTEEFVSLSPHYAAAACKLGRIWVNCKQMTDVNYIVQHNDSIEHIGHRHEHPILDQYIRVIDNDNNILVVDKPPSMPVHPCGRYSVHTVLGMLREQRGLRGLRVVHRLDRTTSGVLLFARNAETDIKLKRTLRVGDTWHKEYLCKVEGVFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBU5</accession>
    <name>A0A183HBU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4957</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004039">
        <property type="protein sequence ID" value="VDO41587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBU5"/>
    <dbReference type="STRING" id="387005.A0A183HBU5"/>
    <dbReference type="WBParaSite" id="OFLC_0000495601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000495601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000495601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000495601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12280" checksum="9A61F86B83DDB981" modified="2016-09-07" version="1">MEVDTISELDITMSDGRSEFSEYSTISRSLFGPEEGPPRKKIKSPPVISPTASTTSLYSGGSSTIDWTTTGTTLDMQGTRVTRTQYGFRTLQESSAKMCLKVTGYPLPEIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC22</accession>
    <name>A0A183HC22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5033</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004125">
        <property type="protein sequence ID" value="VDO41832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC22"/>
    <dbReference type="WBParaSite" id="OFLC_0000503301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000503301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000503301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000503301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36496" checksum="548BCE864FCC3C33" modified="2016-09-07" version="1">MNSGGLAAVLPSTSVVEEESVVIPNDMTHADERFSARWKERCARFLGCIESAKLIAGRTKQRQEKAQIERLKKERAEMEKYRQRYLEAAMKQHMEQQVKPREMVSSITQSHSHHHPQLLSSSQNYPGYVQSLRTTAPFAPSYPSMSVCKPNIRKRPFEGSDGWTQYAHMAIMNNPRNIYHGKEPEMFQNNASPIQITNSFKYSTMISKQVPYCPTNSYNGGDDVRNPNLLRKIIFNELLSNKSMTKEMQQMNYIVPELEKAEQYDQAKLGSSILPTTSQAQESGASTISEEMNNLSSMPELAESHVKDLMDQIGPFELEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDJ1</accession>
    <name>A0A183HDJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5553</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004833">
        <property type="protein sequence ID" value="VDO43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDJ1"/>
    <dbReference type="STRING" id="387005.A0A183HDJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000555201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000555201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000555201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000555201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28076" checksum="0D7C8624ECF1ECD7" modified="2016-09-07" version="1">MDLDHMSLEKERLDFEREKIAERERRLIEDERRILQEKQRLAAEKEMMAQEAEQRSVGSSYTARQNETSRQPSPAMSRRPLYQSQFNENEQQHLTPSFAPILQDQSPRQRAFLDDIIARHGKLVQVTHTRVAQNPKELTVSQNEFLEVLNDNKNWWECKNVHHRVGYVPHTILSVVSVDRSSPQSLPPQDPTLHVDRKSSQGNAAAHRGASLSLSPRPGIMSDDAPEYIKQRQGKRGEFRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDK1</accession>
    <name>A0A183HDK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004846">
        <property type="protein sequence ID" value="VDO43558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDK1"/>
    <dbReference type="WBParaSite" id="OFLC_0000556201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000556201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000556201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000556201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15145" checksum="24BBE8FB22E24770" modified="2016-09-07" version="1">MTESMVLPQTSDLFNAFPKNIFTFHEFVLTTSRVRPILKFTRRKGRALFLRGYEPFILRKTTKYVGTLIGDGQTNRPDKGKMERKMSIPGEGRGQNPFNSCPLFQFSWHYPCATSTLNGGHGHGHGHLPFTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDQ6</accession>
    <name>A0A183HDQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phorbol esters/diacylglycerol binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5617</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004923">
        <property type="protein sequence ID" value="VDO43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDQ6"/>
    <dbReference type="STRING" id="387005.A0A183HDQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000561701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000561701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000561701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000561701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22796" checksum="9C1DDE6E90AE9CA1" modified="2016-09-07" version="1">MHILNNYQFFLFQFQSSTKSVLFADWASGVSSTLDSETVNKHTTAMVEAVFKNYDHNKDGSISQSEFQQISTNFPFIASFETIDTDKDGLISKSEMNAYFIKICKQSIDFRREFQHNFHETTFLTPTICAHCDKLLWGIIRQGFKCHDCGLTVHRTCKGSVVVECRRINNWKTAATESAKTSRKLLPGIKCVLNIQNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDT7</accession>
    <name>A0A183HDT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Foie-gras_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5646</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004962">
        <property type="protein sequence ID" value="VDO43841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDT7"/>
    <dbReference type="STRING" id="387005.A0A183HDT7"/>
    <dbReference type="WBParaSite" id="OFLC_0000564801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000564801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000564801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000564801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40340" checksum="D06DF93F794C9526" modified="2016-09-07" version="1">MGNAAIAKNRKIYAFFCFKYFRHYKLAYQHCTECEIIDSELFELRAVAGLLNYKICQLSFLHSAALEALAQQRRHSTAFFYLPPGSYPSAAIASIEHLLWKGKQCSLFANLFERAVMGGLVAVSTQHPGMYLQAAAYYYRQANEAIAALNVSPQLSGSIYSNPDPLIPTADIFYGQRPWRTSTENGSLSDPETEKNALIALESRCSPNHDRCIALLSSAMSQFKKYKCLRMQRYMMLLLSDEYLVTGQYVKALQFASHLIWEFRREGFIQPIAMLLLRALICAFRVADVKEFMSLSIQILNLRTFPTFASITEQIVANIALIRQGCPPHVPVPHANMSSAEVHYFSHFVKLLIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEI8</accession>
    <name>A0A183HEI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5899</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005325">
        <property type="protein sequence ID" value="VDO44726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEI8"/>
    <dbReference type="STRING" id="387005.A0A183HEI8"/>
    <dbReference type="WBParaSite" id="OFLC_0000589901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000589901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000589901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO44726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000589901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35986" checksum="D0D083BD5A1168E3" modified="2016-09-07" version="1">MSGYNALGISPLMLAAMNGHAAATKILLERGSDINSHIETNRNTALTLACFQGRTDVVRLLLEYNANVEHRAKTGLTPLMEAANGGYVDVGELLLTAGADPNTAPVPTSRDTALTIAADKGHHKFVEMLIHARAQIDAKNKKGCTALWLACHGGHLETVQTLVKHDADVDAQDNRNVSPLIIAFRRGHIKVVKYMVRHVQQFPSDTDCYRFISTISEKELLTRCHLCMDIIVAAKDRQAAEANRAAESLLEILAKEEEQAKSKKLSKQRQNEKKKAKRKAKKNQADGNTEQKDSDRKDDAIPVNNGEESADEENNSEKANSAVTVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEZ0</accession>
    <name>A0A183HEZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS6050</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01005536">
        <property type="protein sequence ID" value="VDO45224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEZ0"/>
    <dbReference type="STRING" id="387005.A0A183HEZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000605101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000605101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000605101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO45224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000605101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22676" checksum="82D85F2BD07DCC2D" modified="2016-09-07" version="1">MYIRLKPANFVIFAIIIFFLYLGYLIWGREEHFPDVVIDLHDLLSYVLLATELGGRAILDVNDEQKLKVFKKAETDVGKPELLTRADLLSNQLIINVLKRYPGLRVISEEKAEKLSVVDYEKYQPQQQELYTNVKAIVDLFPSRKYVLSKLAVWVDPLDATQEFTEGLLEYVSVMICISLNDIPIFGGIYRPFTGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFS0</accession>
    <name>A0A183HFS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6333</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005964">
        <property type="protein sequence ID" value="VDO46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFS0"/>
    <dbReference type="STRING" id="387005.A0A183HFS0"/>
    <dbReference type="WBParaSite" id="OFLC_0000633101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000633101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000633101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF38">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO46196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000633101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14527" checksum="A544755EC9ECB58B" modified="2016-09-07" version="1">MHHYRTVNEVKENFEIENNRKNKDCDLDQIFASINYRFYGAADCNILRIKPFCKLLFASFSYDIKMGEGDIALSFSGCGFLGVYHFGVLQELNRDGKALMKRVKRCAGASAGSLAAALWTFLPDDAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGI3</accession>
    <name>A0A183HGI3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADH dehydrogenase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6595</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006359">
        <property type="protein sequence ID" value="VDO47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGI3"/>
    <dbReference type="STRING" id="387005.A0A183HGI3"/>
    <dbReference type="WBParaSite" id="OFLC_0000659401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000659401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000659401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000659401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36831" checksum="D872EA21F72A4174" modified="2016-09-07" version="1">MILESVRKKKLIFANEYHVRIVSDGRWLLLKNVPKCGLGWKLLTELVQEAQHVIQWPFVNGLKGHKIVSFLDFALIFFYYLGILIITVFILQAIAFSTLLERHFLGRSQCRICPNKVVVERRVIAAVHFFLVVFFVYASLWFCFNNFFRFTLPYFFCLSSILGFLFILLYFLVFLVVASILLLEIMCLCLNNGLCLSFSFCLLFFAFFSPFFCLVLVDLHRAPFDFSECESELVSGFNVKYSSAGFLLYFWVSMVFDSFINVLVVSFRHQVVFWTSGLLFSCLSLELVWIFRFPFLIFLGREFVLLLWRRQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHG5</accession>
    <name>A0A183HHG5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6924</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006895">
        <property type="protein sequence ID" value="VDO48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHG5"/>
    <dbReference type="STRING" id="387005.A0A183HHG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000692601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000692601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000692601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000014">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000692601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40890" checksum="5CF993804860E104" modified="2016-09-07" version="1">MDLTKVTLPTFILERRSLLEMYADFFAHPDSFVGCTDYSSSEERFISVVRYYIGAFYAARKSGVAKKPYNPILGETFRRWRIPGMKKIKEFTERGPFPGSDQNDLTFIAEQVSHHPPVSAFYAEHPGKRVSFTGHIWTKSSFLGLSIGVTNIGWGIVKLHDHNEEYVLTFPNGYGRSIMSTPWIELGGKVIFDLTLVLAVASFQVTVNCVKTGYSAEIDFLTKPFFGGKAHRISGSIYRSGFRKPILTIKGEWNGVITAKPLNGEEYLFVDVKHYPEVKKECEPVARQGDRESRRLWRHVTVALQKNNIQLATNAKRWIEQRQREEAKIRQDQRIVYHPLLFVKQGEGWKYKDELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHP3</accession>
    <name>A0A183HHP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7008</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007042">
        <property type="protein sequence ID" value="VDO48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHP3"/>
    <dbReference type="STRING" id="387005.A0A183HHP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000700401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000700401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000700401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000700401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19228" checksum="A901D7790B2DF56C" modified="2016-09-07" version="1">MDNFSRCRAVYTKPKTTKIAISSKNKRSKSLTKELSPKKAKNAWLYEDAEDADSDASESSETAKKNDVFLHKAKKNSQLKENGTIEKSNVSLVEAEEQYENNSIEKIAVLLNEKEQKEKEASTKVVLVEGNYEPKVEFTGVVQCPDGAIKVVYIEKDGTRAHVVSVRAENNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHS9</accession>
    <name>A0A183HHS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7042</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007091">
        <property type="protein sequence ID" value="VDO49015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHS9"/>
    <dbReference type="STRING" id="387005.A0A183HHS9"/>
    <dbReference type="WBParaSite" id="OFLC_0000704001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000704001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000704001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17678">
        <property type="entry name" value="RUN2_DENND5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF1">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="1">
        <location>
            <begin position="50"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000704001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23147" checksum="C77A461069827ADC" modified="2016-09-07" version="1">MDIKGCVHLTEIQRQLGEATNALVKYFYTNAEARSRGELTQLLCAPGKGFVSVMVAVFLCGRQDSIWSSRLFRSHYPWDYIEKVYVWFWDLMHMEDAKRLTREQRSLITQACRLVRRISSNTFLGKDGKFQLFILITVRDHILSGLLPLMAWTPITSQMYDELSFLRTPHYLNYLSKLISSLNEFQFILEKSLTYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI93</accession>
    <name>A0A183HI93_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7206</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01007363">
        <property type="protein sequence ID" value="VDO49817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI93"/>
    <dbReference type="STRING" id="387005.A0A183HI93"/>
    <dbReference type="WBParaSite" id="OFLC_0000720401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000720401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000720401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="6">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="5">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO49817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000720401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29153" checksum="824B061573C847E7" modified="2016-09-07" version="1">MDLNVKNHGTLKSLIVQKHSREYDKLDPNVDLIELAKKTKNFSGAELEGLVRAAQSSAMNRLVKASGKVQLDADAVEKLMINVDDFNYALENDVKPAFGHSNEELEKYLVGGFISWSAQVTQILEQGALLVKQVRSPDTRGFASVLLAGSPNSGKTCFAAMIAKASDYPFIKVISAEDMVGYTETAKCATLRKVFDDAYRSPLSCVIVDGVERLLDFSPIGPRYSNLVLQALFLLVKKLPPQVDFFNRSRTFLLKIRNLNSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI95</accession>
    <name>A0A183HI95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7208</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007365">
        <property type="protein sequence ID" value="VDO49822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI95"/>
    <dbReference type="STRING" id="387005.A0A183HI95"/>
    <dbReference type="WBParaSite" id="OFLC_0000720601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000720601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000720601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000720601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27255" checksum="DD707AB1CC85DE8F" modified="2016-09-07" version="1">MRVNCDNYEEERDIRREILSDQMVERLTRRILWTRRKRHLTDLRTDEAEAKQSASAKSRKSEVLLYPPYDGTPWIGFTAPTILQRSAEQTVDNHSSDKLRSDAMKFGFTEKVLNSGITFEVSNIVPEDVEEESAFIQNNLWVEKYAPHTYADLISDETVNRLLLNWLRLWDECVFQRTVSDVVLKGASNQQLILNNERPRRPSHKVVLLAGPAGTGKTTLATLVAQHAGYRVASLNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIP7</accession>
    <name>A0A183HIP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7356</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007631">
        <property type="protein sequence ID" value="VDO50609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIP7"/>
    <dbReference type="STRING" id="387005.A0A183HIP7"/>
    <dbReference type="WBParaSite" id="OFLC_0000735801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000735801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000735801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO50609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000735801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17531" checksum="AB2DD4D90419D60E" modified="2016-09-07" version="1">MKYTKKARGVVMFVDEDQLRRMLSNLDDIRREDSTFDNYFWWIASDSWGIKQSVIAGYESMTSGTVTIAPDLKVVPGFDRYFKKLRPSNTFLREYWESINCSDEHTNFGECFDKHGIIFKQEAYVPFVIDAVNVVARALHKYIQVLYDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ42</accession>
    <name>A0A183HJ42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007882">
        <property type="protein sequence ID" value="VDO51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ42"/>
    <dbReference type="STRING" id="387005.A0A183HJ42"/>
    <dbReference type="WBParaSite" id="OFLC_0000750301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000750301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000750301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000750301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44051" checksum="FC006079A7C0AAFB" modified="2016-09-07" version="1">MILYKWADFWGKKFEKYKDFRSCASCPLLSSLLEKYLPLAKAFRKDILASDFAKENDFIESQVCVLFALPASSAIPMTQAVLSPLQLHQNQSREQLRKESRSVKRRLTYPKHRSEKMQRIDEVDDSSLVTGIAVNTSQGASVVEHTSCDIEKTAVDHNAKSLFKQLQMNSEEFRNDEKGIKNTGIQTDKKEVQHRSQQINMEDAAFSSLHAERLDFNASAMHNEKIQMDNSANKTDALAQIEATVNSAFQESENQSRIEVLIKCLPWIPNFLRLSREKLIAAVCETNAEEEHCNENSPSRNDIDLVLESDEEMEVAIPTNISYTDDYCHNDVQQSKDHNIEQTTASLLKDKQCHEEDDEVYHSIMVSGASKLSDQVKRRSVVHQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ69</accession>
    <name>A0A183HJ69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WS_DGAT_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7531</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007928">
        <property type="protein sequence ID" value="VDO51412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ69"/>
    <dbReference type="STRING" id="387005.A0A183HJ69"/>
    <dbReference type="WBParaSite" id="OFLC_0000753001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000753001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000753001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000753001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17883" checksum="7D814266D3E1668B" modified="2016-09-07" version="1">MQLIPLSPQPYRPCLLLKWSSASILLDCAVDMDALSSFLPAALCRSKLFSNLPTYPKNAPKQCLKRYGEHVLVDGPFEVHPAQICSTSMDSVDAILVSNWMSLLALPFFTEETNFTGVVYATDPTLQLGRLVMEELLDFFDRVDREERDHSWKKPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJF3</accession>
    <name>A0A183HJF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008067">
        <property type="protein sequence ID" value="VDO51869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJF3"/>
    <dbReference type="STRING" id="387005.A0A183HJF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000761401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000761401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000761401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000761401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9254" checksum="91B62D27F404D256" modified="2016-09-07" version="1">MNSDQLQDWLINLNERWKNDAKVALKDADHERVQLTHETHKTRYLINYLSCNYTDVDLVQPVVALLLSCYYRGGYFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKV6</accession>
    <name>A0A183HKV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS8118</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008934">
        <property type="protein sequence ID" value="VDO54082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKV6"/>
    <dbReference type="STRING" id="387005.A0A183HKV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000811701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000811701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000811701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO54082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000811701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8715" checksum="F8A9E32B64197723" modified="2016-09-07" version="1">MPKYYCDYCDTFLTHDSPSVRKTHNGGRKHKENVRMFYQKWMEEQAQKLVDATARAFTQGRMNNNQGAAPRMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKX1</accession>
    <name>A0A183HKX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8131</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008964">
        <property type="protein sequence ID" value="VDO54160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKX1"/>
    <dbReference type="STRING" id="387005.A0A183HKX1"/>
    <dbReference type="WBParaSite" id="OFLC_0000813201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000813201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000813201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000813201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15234" checksum="E264FC32D59A5C69" modified="2016-09-07" version="1">MSTAGGGRKKALLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKDISVGDRTVTMQIWDTAGQERFQSLGVAFYRGADCCVLTYDITNASSFRSVEAWRDEFLIQARFVDNMFLIMIISYIMFSCSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL02</accession>
    <name>A0A183HL02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009014">
        <property type="protein sequence ID" value="VDO54333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL02"/>
    <dbReference type="STRING" id="387005.A0A183HL02"/>
    <dbReference type="WBParaSite" id="OFLC_0000816301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000816301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000816301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000816301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10207" checksum="D01033A505334022" modified="2016-09-07" version="1">MFQIKVLLRLLTKSDHCFEDNFTDHPVVVSYLRRKLAPETAAVHSGEFIALLEADQLALQNLESNTEVTSAKISTQSTIEEFKVNEEKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLE5</accession>
    <name>A0A183HLE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nesprin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8307</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009279">
        <property type="protein sequence ID" value="VDO55049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLE5"/>
    <dbReference type="STRING" id="387005.A0A183HLE5"/>
    <dbReference type="WBParaSite" id="OFLC_0000830601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000830601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000830601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000830601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32564" checksum="FC2FA3FFED8D8BEA" modified="2016-09-07" version="1">MKVAVTNTRDEEGQIVMEAETAIKCIEDMQEQLSDLSPLSVISTELNEQRATVEKIYSAVLNMEGDITLLRAKLMDQMKKVPNSKQKAVLDNLSALWNPLLEEIKRKHANAERAFDLVNQLETSLKSLTMQVDENRLKLNEISRNKASFIEFLQIFNIYQIRRSDNDIANLIAMKQEVDKQELELSTLETLLHKLEVITTGPSLRKLGREVENATGDLRALLKDIKNILQKAQTSKDVQKQFSRTKEEAQILIDTARETAESLKENDGIPSITKEVLLKSKHHKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLJ0</accession>
    <name>A0A183HLJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8351</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009357">
        <property type="protein sequence ID" value="VDO55224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLJ0"/>
    <dbReference type="STRING" id="387005.A0A183HLJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000835101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000835101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000835101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000835101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37012" checksum="0650158C9453BECF" modified="2016-09-07" version="1">MKCQVQAALAQLLNPFAYYQPHLAALLQQSQLTATNHVQQPQQPPQIQVQNGIGTPVAAQQQQKLIENLLAEQVIRNPTTHDKIDISQPVVADNRNVGLLTSAESVKEHISRLISENEAILEQNPGLIKRRPYHRQVGSQSSIELETGIRSQSNSPGLRDVRLQFTHGQSFYESHKPLALRVTGGPLTNGHPIVKALDKCTCNYCELKFPNDAALVAHEIRCSKSVLLFIFILHYEFHKYLFIFLYFPFHSNNYTVFLLCQIPIFNDRTDFRTLPIYLAKHSHLPSFYKAFFISSLFLFIGSRIEINLGHILLRMSFNDASSISCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM70</accession>
    <name>A0A183HM70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8580</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009831">
        <property type="protein sequence ID" value="VDO56359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM70"/>
    <dbReference type="WBParaSite" id="OFLC_0000858101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000858101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000858101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000858101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15238" checksum="1F5C208EC460B724" modified="2016-09-07" version="1">MASELFSAAVMRSELLPASTMTTGLLPAGVNDRKWKKTSSVSNILLSSKLFTSIERRNMSPVCHHPFIVVWEGARRTYLRNISIIWYVFVLMLNYLSPSSSSSFYMIIARFLTILPLKDGQRRQRLVMYYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMS3</accession>
    <name>A0A183HMS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome partition protein Smc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8785</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010224">
        <property type="protein sequence ID" value="VDO57387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMS3"/>
    <dbReference type="STRING" id="387005.A0A183HMS3"/>
    <dbReference type="WBParaSite" id="OFLC_0000878401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000878401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000878401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000878401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23012" checksum="1EECA9534BEC32FF" modified="2016-09-07" version="1">MNTLIEELRAKLSDAERAMADLQNRDNILERENSDWKEKSDAINMELDRLRDELSSVRRDAEKEINRYNTDLQTARNEIKLLTSTNNEMKSQLNSSEDKINSLNKVITDQQNKIRDCSLMSSKFFFLSITGEIRHLEGELKDAKGNVANLESELDTTRERIHLLDEQNASLQTELNKIKGDMDSLLGENDMLKVITKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN39</accession>
    <name>A0A183HN39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 tensin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010445">
        <property type="protein sequence ID" value="VDO57927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN39"/>
    <dbReference type="STRING" id="387005.A0A183HN39"/>
    <dbReference type="WBParaSite" id="OFLC_0000890001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000890001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000890001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000890001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17608" checksum="4C691FAE0397DC55" modified="2016-09-07" version="1">MIIKKLLACHTLKARLPLDSRAISLWDADNDPETVYVTVIVANGVRLENSGGREIRKFSQRDFLNNDFYGHQKFDLAVFIKIYSLDPATPCIADAASLWGPPRFTSRLQLIHVNKTVNACFFKNLKSLKVLKHASYQSEFKIIHIGKFSPIALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNG1</accession>
    <name>A0A183HNG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010678">
        <property type="protein sequence ID" value="VDO58419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNG1"/>
    <dbReference type="STRING" id="387005.A0A183HNG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000902201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000902201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000902201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000902201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17528" checksum="67E3F91EA751B055" modified="2016-09-07" version="1">MLLKGKCLKSSRSGQNSLAKKIDRTRSFDTKISFPLSPTVAQTGSENNKGCFPAELLPENLEWSNLSRNYFLLASSSAAEETEDRQYVKPCYDGGTLRTDLEEVTNPVKTNVDQLIKANIERTHPSVSKQQFLPHPESRKAFLTTTELSECDDRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNN9</accession>
    <name>A0A183HNN9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase D</fullName>
            <ecNumber evidence="2">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9101</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01010822">
        <property type="protein sequence ID" value="VDO58716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNN9"/>
    <dbReference type="STRING" id="387005.A0A183HNN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000910001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000910001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000910001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO58716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000910001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11275" checksum="09141A11EA25C790" modified="2016-09-07" version="1">MEMALGINSIYTKRTLQTLHENIKVLRHPDHYLSSGTFFWAHHEKLIVIDQLIAFVGGIDLCFGRWDDSRHKLADCGSVKISEQQISLAGNFSMNKCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP29</accession>
    <name>A0A183HP29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9241</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011135">
        <property type="protein sequence ID" value="VDO59333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP29"/>
    <dbReference type="STRING" id="387005.A0A183HP29"/>
    <dbReference type="WBParaSite" id="OFLC_0000924001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000924001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000924001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000924001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8320" checksum="40A5EDD23FDA8807" modified="2016-09-07" version="1">MLSPGSVSLGGPSAVIDPSFQRVGHLSLNISNVHKTRFHLSDTLYPLDGVIEMKVRCHAEDCGTVGHKGFLVNNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP36</accession>
    <name>A0A183HP36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011150">
        <property type="protein sequence ID" value="VDO59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP36"/>
    <dbReference type="WBParaSite" id="OFLC_0000924701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000924701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000924701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000924701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9740" checksum="E3F03B49AA983AD1" modified="2016-09-07" version="1">MLLDSTSIRQLEIVNGVAQAVFRNVRQALNLLENDRHWDASIIRINDECNTPHPIPTLFKIILSTQHSFGRNTNRIWLKVFSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP51</accession>
    <name>A0A183HP51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L7/L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9261</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011178">
        <property type="protein sequence ID" value="VDO59419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP51"/>
    <dbReference type="STRING" id="387005.A0A183HP51"/>
    <dbReference type="WBParaSite" id="OFLC_0000926201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000926201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000926201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="6">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="5">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO59419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000926201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26164" checksum="AE730AA5CA95510C" modified="2016-09-07" version="1">MVLFYVFVSGGAAEAPLPLEKSASKSSETEKATPVSTKAEKSEDAERSSTISEKKQEVATQIPSMNDMKGMELPEKSVADQKTAQLPLEQGKASPLPHPDGEKVVSERILRLANEIVNLTIFEVADLNSTLKKKLNLPDAPVFAQSFATSATSTTKEEAKAEKPEASQKTFFSVKLTKLDESKKIPLIKEIRTIMEGFNLVQAKKFVEALPGTVKEDLSKNEAEELKAKLEKLGAVCEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP86</accession>
    <name>A0A183HP86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9301</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011263">
        <property type="protein sequence ID" value="VDO59609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP86"/>
    <dbReference type="STRING" id="387005.A0A183HP86"/>
    <dbReference type="WBParaSite" id="OFLC_0000929701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000929701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000929701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000929701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11561" checksum="6F7239803FD7A49E" modified="2016-09-07" version="1">MDEISQKRRSNIASEIASFGFNIFPLEELKDVQKAGIDDLRFCKLIEWMCNEISTLYDLDETVHAPTGPDNMEFFLLELSSMLSELDLEEENSNIRLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP97</accession>
    <name>A0A183HP97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9308</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011274">
        <property type="protein sequence ID" value="VDO59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP97"/>
    <dbReference type="STRING" id="387005.A0A183HP97"/>
    <dbReference type="WBParaSite" id="OFLC_0000930801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000930801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000930801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000930801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11521" checksum="B9A3D8E70C1B7503" modified="2016-09-07" version="1">MHKQIHTGKKPYKCNVCGAKFSNFADLNRHNSTHVLKKLFKCILCGKDFAWVRFSWCQNMNTHKWIPTNKRKFKCGICGEEFRKNGNLPKHQRNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPE7</accession>
    <name>A0A183HPE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAR1-RELATED SEQUENCE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011390">
        <property type="protein sequence ID" value="VDO59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPE7"/>
    <dbReference type="STRING" id="387005.A0A183HPE7"/>
    <dbReference type="WBParaSite" id="OFLC_0000935801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000935801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000935801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000935801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17331" checksum="8990478345277B9D" modified="2016-09-07" version="1">MLHECMKNSQACFILLYLKNFLMKLYGFSDAKVQEYSPSEAAKIYEKAVNNRRNMLMFNPHSALQELRMETVQKRDTVNGHIEMANQIVAFRNMLLSLDRDNGSDHDETDATGFIETVTSKGTINTMTEVEDQDTHMAENVSEVINLSEADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPL8</accession>
    <name>A0A183HPL8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9427</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01011532">
        <property type="protein sequence ID" value="VDO60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPL8"/>
    <dbReference type="STRING" id="387005.A0A183HPL8"/>
    <dbReference type="WBParaSite" id="OFLC_0000942901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000942901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000942901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000942901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18432" checksum="8DA0AE725F80DF8E" modified="2016-09-07" version="1">MTTNMIIVFMVFSINTYHSCKQLNAEYFLSLEETADRLRKEAHSARQEEEGLMNDVETTGQAFEEMQEQNTRLLQQLREKDDANLKLMAERIRANQYQKKMSEERERTEERISSLQNQIEAQQLMISKLEETEKLLRQKNSHLEHQLRNPLNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPZ8</accession>
    <name>A0A183HPZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011848">
        <property type="protein sequence ID" value="VDO61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPZ8"/>
    <dbReference type="STRING" id="387005.A0A183HPZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000955901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000955901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000955901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552614" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000955901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7567" checksum="FEC3534342104ECF" modified="2016-09-07" version="1">MLITTFALCGFACMLSSVLRDDYYRRQQMREREEELRILEGRLREAGIVRKILINLIINDKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ48</accession>
    <name>A0A183HQ48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011966">
        <property type="protein sequence ID" value="VDO61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ48"/>
    <dbReference type="STRING" id="387005.A0A183HQ48"/>
    <dbReference type="WBParaSite" id="OFLC_0000960901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000960901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000960901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000960901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11623" checksum="C18F2B67E01F9D99" modified="2016-09-07" version="1">MVIGKGISSERYAYHCTIDNLSSVMYRGLVNDGYKHPEYLATQDIVICSFETLRKEVYFVEARPRLDSLRHGKRHHIAPTPLLAMEWWRVSYANIFCSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ55</accession>
    <name>A0A183HQ55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9616</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011986">
        <property type="protein sequence ID" value="VDO61938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ55"/>
    <dbReference type="WBParaSite" id="OFLC_0000961601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000961601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000961601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000961601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12899" checksum="D1232DDBC25D65BF" modified="2016-09-07" version="1">MLGRQRTATVTATATTTTADNDVVDDEQALMEKLVYYEKACMSADSISSLVQAIRRQVHAYMQVWRARNKRAVDKSEIHRSLSTCEEIFSQTTSISLAFSHLYACKLSSPHALSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ67</accession>
    <name>A0A183HQ67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autophagy protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9631</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012026">
        <property type="protein sequence ID" value="VDO62030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ67"/>
    <dbReference type="STRING" id="387005.A0A183HQ67"/>
    <dbReference type="WBParaSite" id="OFLC_0000962801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000962801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000962801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000962801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27113" checksum="71AFB32CE1BB181A" modified="2016-09-07" version="1">MSGWTVDESNLNTSCVYCECAFVPSLTIKIHPREMPVKSSWYLPSFFAAKTSDDENTSHCNGDNESIASQLSVPFLSPLVLRRELENLLSGNCLLPVCSSLRHSNPIVFWNVLYYSRRLSLPTHFPSWLGRSVHVRCVYDVPVLHTEFTPLFFVNPSHKDGLLPSSERSISIWQHVIDAVQQSSILRALQIILSENRNAIDNGKFPRRFPLFRYFRSFYSLIHLHNYMSLSLAYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSG9</accession>
    <name>A0A183HSG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10430</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013885">
        <property type="protein sequence ID" value="VDO68390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSG9"/>
    <dbReference type="STRING" id="387005.A0A183HSG9"/>
    <dbReference type="WBParaSite" id="OFLC_0001043001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="4">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO68390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8855" checksum="9CFCC4186CB821EA" modified="2016-09-07" version="1">MTFRVGPVFSTTDPKTFQRHLNSVHVVGGGDCPEMTLSGIQLALEASLPASFIYVFTDARAKDYHLEDQIVNLIQEKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTE6</accession>
    <name>A0A183HTE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014713">
        <property type="protein sequence ID" value="VDO71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTE6"/>
    <dbReference type="STRING" id="387005.A0A183HTE6"/>
    <dbReference type="WBParaSite" id="OFLC_0001075801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001075801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001075801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001075801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27149" checksum="3218A42D982AB79C" modified="2016-09-07" version="1">MEVETHRVAAADLVIPTVDTVRHEMLLNTWLSEHKPLILCGPPGSGKTMTLLSALRSLQDMDVVNVNFSSSTTPELLMRTFDHYCEYRRTPNGVVLSPVQISRWLVIFCDEINLPSPDKYGTQRIISFLRQLVEMNGFYRASDQTWVSLERIQFVGACNPPTDPGRHPLSLRFLRHVPVVYVDYPGQTSLLQIYGTFNRAMLRMAPSLRSFADPLTNAMVDFYLQSQVSLRFVSVLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTS1</accession>
    <name>A0A183HTS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10886</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015040">
        <property type="protein sequence ID" value="VDO72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTS1"/>
    <dbReference type="STRING" id="387005.A0A183HTS1"/>
    <dbReference type="WBParaSite" id="OFLC_0001088301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001088301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001088301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001088301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10844" checksum="576795C517812F49" modified="2016-09-07" version="1">MAVVIPCVLGLFMAIFVWRSLVRQIDTIVMAPPDGVELPPLVNKPPGFYVPLHRRPLIYLQLAKEKIFGKKGVYVSFHRNFLVILERQIGEISNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTZ8</accession>
    <name>A0A183HTZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10964</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015247">
        <property type="protein sequence ID" value="VDO72742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTZ8"/>
    <dbReference type="STRING" id="387005.A0A183HTZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001096001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001096001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001096001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO72742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001096001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10203" checksum="06C977596351570A" modified="2016-09-07" version="1">ARRRRRGYGSGAYVLEVIGPYADETETLEQKFTRLNCEINDLTEAVQAQKMSEKPDASVVNEEDLIALLETLKALQIEKDTIGTSTQSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUI9</accession>
    <name>A0A183HUI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11155</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015747">
        <property type="protein sequence ID" value="VDO74286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUI9"/>
    <dbReference type="STRING" id="387005.A0A183HUI9"/>
    <dbReference type="WBParaSite" id="OFLC_0001115101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001115101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001115101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO74286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001115101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17741" checksum="D1FA075E214067CE" modified="2016-09-07" version="1">MLHDIMVEESKFAHKRDFNLVQTAAKWLKENDNGRANDVIFINFGFSLFFIKELHFEAKWKYQFLPLNVETNFNLSPTETINLPMMERTAKFPFYEDENVQVISLPFEKFQMQMIIILPKLINGLEEVEMELTGEKLNHYIDSLAINEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUW6</accession>
    <name>A0A183HUW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hexokinase_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11275</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016088">
        <property type="protein sequence ID" value="VDO75241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUW6"/>
    <dbReference type="STRING" id="387005.A0A183HUW6"/>
    <dbReference type="WBParaSite" id="OFLC_0001127801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001127801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001127801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001127801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6169" checksum="6770ABD861216910" modified="2016-09-07" version="1">MAEFKLSNETLRRMMAHMSRNMDKGLEGGPEKSTVSMLPSFVPELPSGTDNNNING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV18</accession>
    <name>A0A183HV18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11327</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016251">
        <property type="protein sequence ID" value="VDO75675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV18"/>
    <dbReference type="STRING" id="387005.A0A183HV18"/>
    <dbReference type="WBParaSite" id="OFLC_0001133001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001133001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001133001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001133001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12536" checksum="45E4B15FB02E8DB0" modified="2016-09-07" version="1">MAELDYLFLASVAFLTSTLMFIIFRVIKLYFDEKRARQRKEALLAMAADEHAPRNEREVVVVGGRRVQTARRRVRHAADGNNDGGMGFVRNALDQVEDASEQGKFCYLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVI1</accession>
    <name>A0A183HVI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016661">
        <property type="protein sequence ID" value="VDO76902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVI1"/>
    <dbReference type="WBParaSite" id="OFLC_0001149301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001149301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001149301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552645" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001149301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10243" checksum="ABB7B37E599C40A6" modified="2016-09-07" version="1">MKFFILLTTGLLAVTAIPQQRGREQLQQQQPNVPEAPPFLQGAPPNVINDFFNLLKADENKTDAETELDVEKFIDSLGGNYRVCFCFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVK9</accession>
    <name>A0A183HVK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11522</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016712">
        <property type="protein sequence ID" value="VDO77063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVK9"/>
    <dbReference type="WBParaSite" id="OFLC_0001152101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001152101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001152101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001152101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="5948" checksum="427F1DA87A48E134" modified="2016-09-07" version="1">MLNCEQIIPSASAYAPTNYPDKGHLINDMLCMFDLCYLPLAPFSATTRGHMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW71</accession>
    <name>A0A183HW71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11735</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017358">
        <property type="protein sequence ID" value="VDO78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW71"/>
    <dbReference type="STRING" id="387005.A0A183HW71"/>
    <dbReference type="WBParaSite" id="OFLC_0001173301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001173301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001173301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001173301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12533" checksum="5C999D3F8878669D" modified="2016-09-07" version="1">MWVKELKRMLGDDVFLVIIGNKVDLERNRNVDSNEAIEYAKSIDAEHFETSAKDSIGVTQVFDYLVKGLVERARHSQFQDTDVASHYSASRRNDLLIIDDPPTAKKSCCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWP9</accession>
    <name>A0A183HWP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA_lid_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11910</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017825">
        <property type="protein sequence ID" value="VDO80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWP9"/>
    <dbReference type="STRING" id="387005.A0A183HWP9"/>
    <dbReference type="WBParaSite" id="OFLC_0001191101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001191101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001191101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="3">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001191101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12115" checksum="274A42CE422B1124" modified="2016-09-07" version="1">EFFFSLHRPKCAGKARNFTFSLLQTFRNVLKIHASKITKHGDIDYEAIVKLSDGFSGADLRNVCTEAGLFAIRAEREYVIDEDFMKAVRKVGDAKRLETKLDYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX29</accession>
    <name>A0A183HX29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018183">
        <property type="protein sequence ID" value="VDO81397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX29"/>
    <dbReference type="WBParaSite" id="OFLC_0001204101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001204101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001204101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001204101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5869" checksum="21E594091C84BDC4" modified="2016-09-07" version="1">MTIMRCSMQSVFVNTHSAFGLNRSFIMRKKKLNGVFTILMKSITTNILMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXJ4</accession>
    <name>A0A183HXJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS12210</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018655">
        <property type="protein sequence ID" value="VDO82833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXJ4"/>
    <dbReference type="STRING" id="387005.A0A183HXJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001220701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001220701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001220701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO82833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001220701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13388" checksum="A01057BC5E5C330E" modified="2016-09-07" version="1">MRFSRLSNLRSHMYTHNGEKQFVCEACGVDFTRSNSLKRHMRIHTKEKPYKCSKCEESFTQSCSLKRHMLTHTKEKPHNCELCGKRFSQPFNLKKHKKNHCKGRFDFNCATCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY09</accession>
    <name>A0A183HY09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12371</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039831">
        <property type="protein sequence ID" value="VDP11174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY09"/>
    <dbReference type="STRING" id="387005.A0A183HY09"/>
    <dbReference type="WBParaSite" id="OFLC_0001237201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001237201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001237201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF13">
        <property type="entry name" value="KELCH-LIKE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001237201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="632" mass="71213" checksum="BC66C59862C5ED48" modified="2016-09-07" version="1">MSEAKSSVVKVSRKRKTSKNCRQPVEASIATIAAESSSASEATSTTPLSTHSTDFNDYESLALLSSALSVSSASLIVGSAAKFTTQQHFNITATEVNRRRAHAELCKPQLQAPTNATLILNRNTVITIDRKEFAQISPYFRAAFYGGFSETKSRLLSFDRTKSEEFLHCCAILNQLMSENKWKVPNLEWMSLQKAFEILDIASYLLIDPLLTLISDVIVSKINADSLVLAYHKAENRHVPLAQKLWKIIVRQFDRLLINNTFLALSEIEILKLLCDRHLNINKNEETTMVRKWITANDYDGSGAIRLRQELCGRNDTVGFSENEPRLPNSVLLASGGWSNLGPTMLVETLDSRAQRWIRSELKLFELPRAYHAVINTGEHLFTIGGFNGAEYYRSTRRFSLNNQECMEVAPMYDQRCYVGCGLLDPERIIAIGGYNNHDRLRSAEILHIPTNQWHRIAEMSVRRSDGHCVIMKNVAYAIGGFDGMNCHASVEYYEPQRDRWFIVSNNMTSRRSGVGAAILEGVVFICGGFDGTSRLQTCEFIDTREGKWHRLRSMNRPRSNFGIEVLNNQVVVAGGYGGMVGTIGETEAYDFRSNSWIELPTMSLRRSALYLTRVENHDIIDAFVRPKCTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYB4</accession>
    <name>A0A183HYB4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12476</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01039851">
        <property type="protein sequence ID" value="VDP11408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYB4"/>
    <dbReference type="STRING" id="387005.A0A183HYB4"/>
    <dbReference type="WBParaSite" id="OFLC_0001247701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001247701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001247701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000060">
        <property type="entry name" value="Probable beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552687" description="beta-mannosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="12">
        <location>
            <begin position="860"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP11408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001247701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="932" mass="109627" checksum="B495B806B7473695" modified="2016-09-07" version="1">MLVIVPLFLIFEFRFGKAISNDGNFQLDKFQWHFQSTNGSIRGLARVPGDIYQDLFFANYISEPLFGENDRLLRWIPRTDWTYYTTFTIPRNWNTVKAVLLNAHGLDTVADVFFNDVLVLRTYNQFVSHLIPLKQWKIGKNYLRIEFESPINYAKKKSDEYQEQFGHVIPPVCPVSEFQGECHINFIRKIQASFSWDWGPSFPTVGIWKPISIEGVQTIFLDKISARKLIIEQHFIVSVRITVWSAVKVKYAGIILTLPEISITNQFTTSFESMNRNIVEQKISVHNSDIERWWPNGYGKQKLYKLIVSVCYEGQNFTKEMRVGFRTVELIQDYVNSEKPKLGRYFYFMINNQPIFLKGSNWIPLSAFPARNHRFREKFLLESARESNMNVLRVWGGGRYESDHFYDLADELGLMIWQDMMFACALYPVDKQYLNNVREEIYFQVERLQHHPSIFIWAGNNENELGIRQWFFAENYSFTDSVVDYMKLYNETIRPIIAKLDNTRPYLLSSPTNGVESEKEGGVAKYPTDERYGDIHFYNELDDLWRDSTYQIPRCSSEYGVQSFPRKETMLKWVNETHWSYTSEEMRRRQHHPGGFLAQLSMIFSHFKIEYVSSGKIPSECGKTMSDDCVYLGTERFMNRFVYLSQFHQAVTYQVQTEHYRRWRGRLTEDGRGNTMCALYWQLNDIWAAPTWSTIDYELSWKPAHYFARRFFAPVILSMAIDEEIHVFIVSDLIKPISNVTMVLETFWFGNFIPVESFKQQISSISQQSSIEIPIDRAIYDKIKRIVKSGKYNCAKHARQILYHCCREKINDRHLLRGRILSNDGTQIGYDAVHLPDKLFKVDEVNFGKAWIRKLQRKNNMLYELKLEADKIAPFVYMELAPGLIGWFSDNAFTMTESKKRVILFLFKDPQRQLTKSDISICSLHDCGKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYS8</accession>
    <name>A0A183HYS8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta'-coat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS12640</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039891">
        <property type="protein sequence ID" value="VDP11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYS8"/>
    <dbReference type="STRING" id="387005.A0A183HYS8"/>
    <dbReference type="WBParaSite" id="OFLC_0001264101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001264101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001264101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="319"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="593"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDP11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001264101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="723" mass="81829" checksum="C3CF57E27F16C4B0" modified="2016-09-07" version="1">MPLRLDVKKKLLARSDRVKCVDLHPTETWMLVALYNGNIHVWNYENQQLVKSFEVCELPVRCAKFIPRKNWIITGSDDMHVRVFNYNTLERVHQFEAHSDYLRSIAVHPSQPFVLTSSDDMLIKLWDWDNKWSVKQTFEGHTHYVMQLVINPKDNNTFATASLDKTVKVWQFGSSTANFTLEGHEKGVNCVDYYHGGDRPYLISGADDRFVKIWDYQNKTCVATLDGHAQNVSAVCFHPELPVIITGSEDSTVRLWHASTYRLETTLNYGLERVWCIYALRGSNTVAIGYDEGSVTVKLGREEPAVSMDSSGKILWAKHSEMQQANLKTLDATMLEQLQDGERISLSIKDVGSCEIYPQTLAHNSNGRYVVACGDGEYIVYTAMALRNKAFGSGLEFVWSTDPSEYAVRESASNIKIFKNFKEVRTLRPDVIMEGIEGGPLVAARSLNALCFYDWETGSLIRRIEISAKHVYWSDNAEMVAIASDDTFYILKYNKEAVENVAAADIDGIEDAFDVIGEVQESIKTAIWIGDCFIFTTDLNRLNYYVGGEIVTIAHMDRPLYLLGYTPMESRLYLCDKDHNIVSYRLLLSVLEYQTAVMRRDFVTANTMLPVIPRDHRTRVAHFLEKQGFKKQALVVSQDPDHRFELALSLGDLKLAYDLAVTADSEEKWRQLSQAATLKSELMLAGECLGRARDYGGLLLLATSAGSATLVCVSQIIVFFLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZD5</accession>
    <name>A0A183HZD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039953">
        <property type="protein sequence ID" value="VDP12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZD5"/>
    <dbReference type="STRING" id="387005.A0A183HZD5"/>
    <dbReference type="WBParaSite" id="OFLC_0001284801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001284801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001284801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001284801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="20071" checksum="43B1ADB78AC6772C" modified="2016-09-07" version="1">MGIGRYCNKLFLIDFGLAKKYRDSRTHVHIPYRKDKNLTGTARYASVNAHLGIEQSRRDDVESLGYVLMYFNRGSLPWQGLKAITKKQKYEKISEFEMYFRYCHGLRFDEDPDYAYLKQLFRILFKKLNYQYDYTFDWTTLKQKETQKTVSLAHAPNESSKKNMETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZK6</accession>
    <name>A0A183HZK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS12920</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039976">
        <property type="protein sequence ID" value="VDP12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZK6"/>
    <dbReference type="STRING" id="387005.A0A183HZK6"/>
    <dbReference type="WBParaSite" id="OFLC_0001291901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001291901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001291901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001291901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1027" mass="117709" checksum="31EA8D01B7398844" modified="2016-09-07" version="1">MLKVCSVGGTKLDCCAMSQKVLTDLGSCFVFSIGDMKLNQTQPGIYNGLQLILDAGINDAIAVNYAEEGNTLPIFSNNLEDGFRLYVRSENELAYSYTEGLSVSPAYRAYIALNLETFHFLTPENWGNCTHIWPPKSPQRAFRLPYTAQNCASLCQQIYYEQRINCTPLLYSVGDAHLNTCTPSELHAFMLQVADRTNNINGPECADNICPTSCVTHEYKASITYGYGFSESAMDWLTNINNNWTQKRIKENFAVVNIFYREMSYILNEQMQSTSLVDVLSNIGGNMGLFFGASVITVIELIIFLSKLAWIAFSSRRREYMFHKRQKERDRERRLTSVINIAAKAPNRRSRKMVSLSKCGLAGKQSSRLQSLPIIAIDFTLTLLNTRSTLRSEAVMVLSQMERLINWFKEVAVRRNLVEHAIKKEFFQLMGATKLHGCYRIYAGKTYGRLFWLLMAISTGVIFIIVLAELTKQYKAENVSTQVEIVYDYADGPSITICSHNPVRRNYIEELKRTTTFSDELLMYLLHIFLRPEGLVKMNVMESLRDGERLLQDYMLAYKNFTVESFVKEASFKCEEAFVQCAFEGIMFDCCNEKYSTAVITDLGYCFQFDWNKLSKDFSLSYHFGSVHGFQVMLDYQSYNEVYLVNYTGIIFTELNRKSNTHSSILCSFINVYILFLLTQQQNSVSGSRIRQPFLDNFETGFRLYVHDKNTVSYVNSEVLVVSPNTKLSTGLKPIKYQFLERSKGGTCCNTWPSTLHHNSTYSSSACKMTCLARHFYMNCGCVPLQYNILKEGRLCSPKEVFDCINNFKEIASTVRNVTYSPLCQNCAPECELFIYFTQNFIIHNILTSLGEYMKSLKQQYKLSYVRSISIMPRFFTNSWMLLYVKQHLQNKLMTYGLVKEQSGNCTFTGKIGSDMGLFYGASVISLFELILLLFKTIWALASPSRTVYLKEKANQERLLSFIFFVFLDGLKFVHDRNIAMSFQRPQRKLDHVMSLTLTPEQASAILEAETFVDSIYVPLRRDKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I029</accession>
    <name>A0A183I029_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13091</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040041">
        <property type="protein sequence ID" value="VDP12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I029"/>
    <dbReference type="STRING" id="387005.A0A183I029"/>
    <dbReference type="WBParaSite" id="OFLC_0001309201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001309201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001309201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="MRCK/ROCK kinase PH" evidence="5">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001309201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15516" checksum="FC56BEB7C860695C" modified="2016-09-07" version="1">MVKVIGFLIFTCKHRRNVPTFEKYNFLFHIFSGLFCQDCQYACHVACLPKVPLVCPVPPEARRPLGIDPQRGTGTAYEGLVKTPKPSGIKRGWQSTYVVVCDFKLYLYDCSTDKHGKAIDIHPVIRQVTVIVFPSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I156</accession>
    <name>A0A183I156_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2655 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13468</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040214">
        <property type="protein sequence ID" value="VDP13831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I156"/>
    <dbReference type="WBParaSite" id="OFLC_0001346901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001346901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001346901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001346901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9544" checksum="9C99D61120024E73" modified="2016-09-07" version="1">MQSNIPKIRCLSHNDFSLTLENSEKLLHEGSCSRRAMLSCDCPTCKPLPPKLFRIDKLESRRYFAVQPSTSIRITKTKHVNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1P8</accession>
    <name>A0A183I1P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor IF-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13660</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040320">
        <property type="protein sequence ID" value="VDP14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1P8"/>
    <dbReference type="STRING" id="387005.A0A183I1P8"/>
    <dbReference type="WBParaSite" id="OFLC_0001366101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001366101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001366101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001366101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40248" checksum="69F88C97CD1B8283" modified="2016-09-07" version="1">MATKKKNNKKNDWSEDLDAEATELKLSDSEIDEDNGSDEETMVPFYGKGKISAFNMLAEHDSDSDDIEKAESISENSDKADEVEGNKQEKGGVNEKNKPNETKAFSKQQTTIKLKEEGKRKGRKGKKGLKEDEDLDALLADLEKPIEKASKEKKKKGAASGISYTAEVPAVDADRDGEIATTETDVGDVMTKKKDKKKKKKGTAEKEKSAEFESPAEGDAVSVENQRVSGYICSVKASDAKEKKKKKKGDSKKDGDKKETKKKKHVDFIKEILRRKQEEEERILREQKEEEERLIAQQKAKEEEERLAKEKREREKQKKKERDEKLKAEGKYLTPAQKEKLRRQQALLANSSMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2V1</accession>
    <name>A0A183I2V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14063</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040571">
        <property type="protein sequence ID" value="VDP15398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2V1"/>
    <dbReference type="STRING" id="387005.A0A183I2V1"/>
    <dbReference type="WBParaSite" id="OFLC_0001407101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001407101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001407101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31430">
        <property type="entry name" value="PROTEIN CBG22332-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001407101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29432" checksum="067346EFD83898F9" modified="2016-09-07" version="1">MQKTSRSELRQERPIQNPEASIEIGMCCIFLQTRYCDGPCGKKRSVKEFQVHGQCEHAICPLCTINAPMIENSDGSIGCCNLECFAADLATLCPDPVLRHKYFQMIIKKHKINEITTCQGRKGRNMKQPQQAMEPLSSCQTLSLSQSSNDKRGLKKPMCIKVLVLEKGPLETTCRRRSISEIDSIESLRNTLQFVVGDGPNLYKSRIFFNCGDAEDFKLQKIDLKRYGDKKISYFPSSNGILNFVIDYTNLIGGNSISPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2X5</accession>
    <name>A0A183I2X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14087</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040589">
        <property type="protein sequence ID" value="VDP15454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2X5"/>
    <dbReference type="STRING" id="387005.A0A183I2X5"/>
    <dbReference type="WBParaSite" id="OFLC_0001409501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001409501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001409501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001409501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22595" checksum="C3422202864772BE" modified="2016-09-07" version="1">MRINEHTKLIGQKVILVPYCKHHVVKYHTWMENEELRRLTASERLSLEDEYKMQARWCEDDDKCTFIILARDLLDSGLDEIASMVGDINIFLNDSIAELTVMIAESEWHRKGLGEEAVRIMLKFAFEIIGLRIFEVKISDDNISSLKLFQKIGFFLTSHCSKFHEYTLSIGVKHILEAISHLEVTVDKYAYNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4M1</accession>
    <name>A0A183I4M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14683</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041082">
        <property type="protein sequence ID" value="VDP18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4M1"/>
    <dbReference type="STRING" id="387005.A0A183I4M1"/>
    <dbReference type="WBParaSite" id="OFLC_0001469401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001469401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001469401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001469401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="701" mass="78279" checksum="36C37A923329EA2D" modified="2016-09-07" version="1">MNEMENKAVEATMSSSFTDKMTSCSSLVCKYDGDTDDVHIENQKIQQKQGQCLGSQPIQNDLPTNDSMNILEDVVRCLLDKDTSALGFQIAQRSDGICISYVEPNGPADRSGNIFVGDKIKEVTITFENMPISDALTILSCASTYKIRLELERAIINDTIQSDCTDATEHFDTSNPIQLSSFLYKSHSTSDLTPQSQKAQMSDKTVNGGSFMSKQKYQLPRQSVINTIKEEASSIIPETSLPSSPSSDFIEKTEFVPAMTESVISEETIIISDESLEPQPSVLRSLETSPNEISLQPQNQPCVVTSKTKPKVNCTSNSTPLNIFRKKLQISSPFSENPILSLIPKENHKVDEIRCNGFSDFIERSHFMYSNASIKNDIRKNCVEFCELIEPKRESIVMEFEENHGDDDYQQVEEEMIILSNCNDTFDKAENDLYQANSNLNSVAPMEAPPNCAVIDAVHTEKDDSVSGNISNRTNVKCNTSHYPVVTVEALTDPPRRTDTIENKFSNFYTEISFPNGAGQIAGKKSSEISNHPEINEFNGKHLIESRTTVVESPSIPRKIINDNTSLNETSQRSTKRSQLRKLSNNCGINEAGKEIRKPNDDFDDLKDEGNNRSNISQRSPKWSPKLQSHIPIVTRTPSTKSKNKLSKVENNKVAGNSTYVTRNKMSHDTGKNDMNGASLYIAKKEALRKTHLPFSKLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Q6</accession>
    <name>A0A183I4Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041122">
        <property type="protein sequence ID" value="VDP18406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Q6"/>
    <dbReference type="WBParaSite" id="OFLC_0001472901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001472901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001472901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001472901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10842" checksum="6441CFFB132876F5" modified="2016-09-07" version="1">MDMLDKFGEYFGRRKKRSSGVGIVPLLSLISDLCSSHSLSLEEAEDGATQQEVVGQDEVCVTLYPPFPPPPPPPSSPSLTAAWIIIFLIREHLRCRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5B5</accession>
    <name>A0A183I5B5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14927</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041367">
        <property type="protein sequence ID" value="VDP19622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I5B5"/>
    <dbReference type="WBParaSite" id="OFLC_0001493801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001493801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001493801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059093">
        <property type="entry name" value="HA_Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26202">
        <property type="entry name" value="HA_Alsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Alsin helical array" evidence="2">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP19622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001493801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59770" checksum="4DA2F591068DBC7C" modified="2016-09-07" version="1">MSIPIDGNLHKVNTYLRNKEERTLEVDIYTGFWHNGRLDGLAHITFANGDTYEGYMEKGLRHGYGVLHASKGDTMEIYFGGWQAGMRSGYGVSTNNSIIVTTXXXFGGWQAGMRSGYGPVNLHETVLINNIFSYNVSTAFSEERYLGMWMNDSRHGKGILIGIEGVYQEGQFDNNRLVRGRLILSGTDDYSGAVFEGDFEKAGIICGKGTLYLNQFDCIEGRMTGDIINGEVKISNATYWRQKPVPLSSFSLDNDLPSTATQWAIDPKLKWKELFESFLVYDLNVPVHVASAVDVSEIADDACRVAVWNSLASSMVKIRLGMNKEEIKVTFDKNLEKIPQYTLQWSNKYYEMVQQYWNLALRHKYHPLRRLVFGLFEVFTGSYGTIGIHRAVCKQAVCELRSIHLKIYSVMRLLFSSLPHTYEMFAPMSICIDNNLTSKNIDCDSQSLKEKNSAKRNDEPNFRVSLLYPSCNFIIETLFSECYAVIFTLYSVNCADLDRRYWERVVYLNAFTDVKLLAYLEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5M1</accession>
    <name>A0A183I5M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPX2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15033</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041513">
        <property type="protein sequence ID" value="VDP20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5M1"/>
    <dbReference type="STRING" id="387005.A0A183I5M1"/>
    <dbReference type="WBParaSite" id="OFLC_0001504401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001504401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001504401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001504401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32174" checksum="8E990B929E0ADF57" modified="2016-09-07" version="1">MELSKVWNDHECNKENIAPKEVAESKVLIYKFVARFAALHQKLAEKQPTLEEADANVKRKFAEHEKAVPNIFKRLATPKFSKKAKPEMTVAVEATGYKFKNVAEDPSKMNFLFSKLYGTKNAFATVQNNTNVASQSRIPLPHRSRMVGVKELTKKLNTKQVRRSPRLANLTKHTNSVTVPKVSTRLQRLAIPKGKHPEVSLVESEKKSVRRCGQRYVPYRRMMPYVDTTKMTDSQFHEAKMLGQIQTFTAVSSSRTEMRQQLRLKRDEARERIMKAKRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5X8</accession>
    <name>A0A183I5X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS15141</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041669">
        <property type="protein sequence ID" value="VDP20568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5X8"/>
    <dbReference type="STRING" id="387005.A0A183I5X8"/>
    <dbReference type="WBParaSite" id="OFLC_0001515101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001515101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001515101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP20568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001515101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36730" checksum="485F6D54BE9FD9E7" modified="2016-09-07" version="1">MQKEKYQNFIAGWGAGFVETVLLYPPNKMIFRQQLQGITAKEVYQQLKNEGCWMLYRGMLPPLIQRTTTRSVMFGMFDKFHRYFGCSECRTAQTRIACFSCAAFMVAYSLTVTCSILAGAVEAISCPLERTQVLLQSPKYNQRYQNTGHAFKELARIGPKELYRGFTIVLLRNGLSNVFFFTLRKPFRDLVIDCDQQCISHYIGVRIPEQLVTFIGDFISGAVLGASISSLFFPLNVVKQRMQSTVNSPFSSAWTIFQVIWIERNRSFKELFRGITLNYTSLLVWLYVFGTYGNDDKLVRVSDTSMTLSYASILSHMNDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5Y1</accession>
    <name>A0A183I5Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15143</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041670">
        <property type="protein sequence ID" value="VDP20570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0001515401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001515401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001515401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001515401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13104" checksum="87022EFF002A13C3" modified="2016-09-07" version="1">MIDEDITRTDFEVKEAFCDTGLTTITDLQPHANNYLPILLSNPAKRIISSKQAWEGGFGIPSITKNLEERRISNSITTTINIRHGWNQEKEDVGGAVGKGKIGDKKKLAGWMDGWMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6R6</accession>
    <name>A0A183I6R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fox-1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15428</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042123">
        <property type="protein sequence ID" value="VDP21833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6R6"/>
    <dbReference type="STRING" id="387005.A0A183I6R6"/>
    <dbReference type="WBParaSite" id="OFLC_0001543901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001543901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001543901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001543901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12056" checksum="1EC3655289241AD8" modified="2016-09-07" version="1">MVRDSSGHLETPSTAFFGASFGLTQLPGVVKPENLMPTLSERPVALTAMSDAAAAVAYDSRIIGAAPYYNSGYSGASYAGMYAAGGPQNYYPVVSSSLRGPATSFPFAAAAASHAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6W0</accession>
    <name>A0A183I6W0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15472</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042204">
        <property type="protein sequence ID" value="VDP22037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6W0"/>
    <dbReference type="STRING" id="387005.A0A183I6W0"/>
    <dbReference type="WBParaSite" id="OFLC_0001548301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001548301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001548301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001548301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22265" checksum="90FF65C67FAB5936" modified="2016-09-07" version="1">MLSLIDKEDETKWNSYEIIFFYLQTKLEYFARLMSKYGKDPNVLSDLFRTSVLPIYSYGMSNREMSLLALLLAKYLHEEIKELKNPIDFRNASSFAILQILIESYGKTESQRLQIAELNQKLNNTEFREKYFNLNPINLFESITTAKPKNINEAMKNATVAKIFNNSKQFLIHWATAYAEIIFGKITEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I828</accession>
    <name>A0A183I828_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043145">
        <property type="protein sequence ID" value="VDP24595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I828"/>
    <dbReference type="WBParaSite" id="OFLC_0001590301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001590301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001590301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001590301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7636" checksum="A0EF7D5BF5357FF6" modified="2016-09-07" version="1">MQFLIMNRIILSILFIAVFQRKISLKEHLLTIFSMNSVSVLIQVTECFINLNLQQFLFKKENFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I855</accession>
    <name>A0A183I855_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15917</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043238">
        <property type="protein sequence ID" value="VDP24879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I855"/>
    <dbReference type="WBParaSite" id="OFLC_0001593001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001593001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001593001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001593001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13101" checksum="8B32439447A5683D" modified="2016-09-07" version="1">MKSRITCDTEVPISTSNGNKFDHCTGIRYHNYSLPHGKTIDNDIDKQYDKPQKDDHYSMEIIKSIQGTTTTMKCENNNHQSSDKGYSGIRSYDIPKDTVNSHILERLLFIPIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VBT5</accession>
    <name>A0A3P7VBT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001263">
        <property type="protein sequence ID" value="VDO32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H453"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="158" mass="18294" checksum="FADB713C8A132C14" modified="2026-01-28" version="1">MDDPCERTCYVCNLHENVTEELLKELFSQVGPLDTIILRTSNSRDCGSAHRYALIVFKHEMSVPFACEMLDRIELFSKQILVRPKQGTQQALQYWSNTSVSALHNSTPSPSTTQNHASSRLFDTYRRRQNEREQHYQKRTRGDKSGVNIFTMFAAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W0W7</accession>
    <name>A0A3P7W0W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002440">
        <property type="protein sequence ID" value="VDO37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W0W7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="221" mass="25254" checksum="D7457F36D8F512CD" modified="2019-02-13" version="1">MNFQTQIIGTESPEEHTTFLYDYQVPCAAFTDKICIEQVTKHFLSANLKHIDECMLHKSILIIQKKRLGADKMSKCCDKGIYLTDLCMPGHCTNATTEFKAINTAGDAFSRCCYHKFIEDDDKCCPARRAKFHWLTAYEICLPNVRVDLSDVRFSMRVASSNDDTKKMNQESNEVVTVDLNADRSWDHSCEQGAKVFQFPYLPVDELAKVKVDNENSEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WU69</accession>
    <name>A0A3P7WU69_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS9969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012800">
        <property type="protein sequence ID" value="VDO64811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WU69"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF13">
        <property type="entry name" value="FIBROPELLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO64811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="138" mass="14789" checksum="D733C59F38E943A5" modified="2019-02-13" version="1">MDECAEGIVVCGGSKNSSVCVNTDGSYECRCAPGYAGNPDSPHGCVDVDECQLSDFYCGEKGICKNLVGSYECECAEGFQRDQYTGQCVDIDECKYEPCDKAAICTNLHGSFRCTCTDGFVGNGVQCHGKILPDFLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YER2</accession>
    <name>A0A3P7YER2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3199</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01002066">
        <property type="protein sequence ID" value="VDO35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YER2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="207"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="387"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="575" mass="64212" checksum="5A9287056FA24D81" modified="2019-02-13" version="1">MIVYFSPRIYSSQQHSYTYSQQFLGAAEERGDSDGTEIGIGILRPNFAYSASPTNQHKQEQNTTGDGEGFSHWAALKMIMTERAAQCFAKLGLDAAATTASSTKNISHLQTSQPQNTITATDSIVTVSAAPNDLAIASGYHRRSRSLRERTGVDQRLERLPSGPIILQKFTAHTVIPGSNIEKSRPVLIHNFAEHVRLMSADSDFRFSEEYENLKLVGHGQTCIAADLTVNRAKNRFTNILPYDHSRVKLIPTDDDDGSDYINASYIPGFNSRREFIAAQGPLPSTRDHFWRVVWEQYCPAIIALTKCVEKGRDKCHQYWPDNDQLSVLYADIEVTLMNETVYEEFTVRELKLTNMNEPVASPRTVKHLHYMAWPDFGVPEHAAGLVHFVHLFRTRLPPSSNNKPTIVHCSAGVGRSGTFIALDRLIQCVAKNLPLDIFGIVYEMRLDRCHMVQNEQQYIFIHHCLLYVLETEYNIGTNLISNNLSQIDGSVTSTFLSDNVIGFSNSIISNDIGNKLCMEITNSDVQIIGSNGGTTFIGNVSQHQPNATWITTPRVEVHLNPAFDDDEGIAESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YIG5</accession>
    <name>A0A3P7YIG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003371">
        <property type="protein sequence ID" value="VDO40002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10019596at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="91" mass="10492" checksum="97BC1015B274DCDE" modified="2026-01-28" version="1">MEYRIMIIFLLFGTIGIQWSIAEFSTDMCIDRVSSLIMSICNGCVQITISSQYSDSDSEAADKKELLHNVAEKCCYRRCFMRYFRSLCCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ51</accession>
    <name>A0A183GZ51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000175">
        <property type="protein sequence ID" value="VDO26057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ51"/>
    <dbReference type="WBParaSite" id="OFLC_0000051001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000051001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000051001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000051001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48625" checksum="EEF659AE2068E57D" modified="2016-09-07" version="1">MIDSALSSNGHNSGNNDGVKKAENQRNDGIIRCKPRKIFPLADERIEDLIYPSTTYHYSVSRDGRYVYVIGEGAELQSQLFVWDLHRGVARRYTVINLPPSLQMKHLYEINSVEGILVCFSIGCFHIYAIRFDHSQELIRIRRTLFYQMSNTSHFWSSARASSEQGIIFLSQNDQIQNFYVAQISLDAPVQSVFLTAHMSGLRFCGQPWVHGNYMYLFESATTIIYSEMKYLTGRLVRANLNTGELDVVYTKATGIIGNSLPAVQQHQQQQQQQQPLHNVTSQQVGNAITLIRRVKHVGRNGWLWIIAEFVEPYESLNQDTNRCEVCVLEMQTFTWYRLNWLPKCKFDELTLDTTCQGTVVMLQKKILANQTQIDSFLLLSRNPETLLKQSFRALITYFPSWRNLNWEEMNSLGIPPHLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0G2</accession>
    <name>A0A183H0G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PCNA_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS972</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000402">
        <property type="protein sequence ID" value="VDO27752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0G2"/>
    <dbReference type="STRING" id="387005.A0A183H0G2"/>
    <dbReference type="WBParaSite" id="OFLC_0000097101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000097101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000097101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003011">
        <property type="entry name" value="Cell_cycle_checkpoint_Rad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01246">
        <property type="entry name" value="RAD1REPAIR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO27752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000097101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31462" checksum="DAF42B27543090C9" modified="2016-09-07" version="1">CVIDISKNGLRIVVDDQNCVQGIAYFKSDIFTEFILNEDVVTFRIPLSIFTECLNAFGAGVSTVMKMTYDGYGEPLKVMLEKNGIVAKCLIKTQNPDIVLDFDFNPANVAAKVIMKPWMLKETFHELDHSSPTVGFRVDRFSLSVITEGDMGKIKTKFPHYSEQIERLECKHDVEFTYRLNLVKRMTSPLDICSKLSLRIDHRGILSTQFMVEHNENNHIFLEFFTSIVLLFSVHLISLYRKKKISLWINAAIYLDYDKFGGFFILSIKVRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0H4</accession>
    <name>A0A183H0H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS984</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000408">
        <property type="protein sequence ID" value="VDO27787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0H4"/>
    <dbReference type="WBParaSite" id="OFLC_0000098301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000098301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000098301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000098301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14134" checksum="CA6065566F4B1958" modified="2016-09-07" version="1">MNTEIVINNTNSNGSNCENVSKRQEDDEIDEADDCSTEEANAIDYPQSIFSTPKDHTWVKKRIVDENFDAFIKTNVKRVKRLSRAGNSRKVKIVQERHNNRFDNSSSSEKNQNHRKYKVSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0W1</accession>
    <name>A0A183H0W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cardiomyopathy-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000485">
        <property type="protein sequence ID" value="VDO28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0W1"/>
    <dbReference type="WBParaSite" id="OFLC_0000112001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000112001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000112001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1890"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1922"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2160"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1931"/>
            <end position="1944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000112001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2291" mass="259140" checksum="5E6D8B869AF9BF2B" modified="2016-09-07" version="1">MQDKAAFEEYGTIIFEELLMKKEHIELQEKAHTLSFEANQDEVKESQNETKTFKQVSPTKAKIEEQLLKTSELEKVQAKSLENIILERDALRENTCMSKELIIDEEPVVSQKKEYNVFAGNMSLAEQKDQVYITEDLDEIKTGKFKDILQQESGVSLKKLITKEEFMVLDENNHKTFFERKYSVPQMEEKHILNERKSIITPLNVYERTVSEEGICMLEKEIKGYPLEMEEEGIIREDAIMEDDKQDGFEFAGQVIKEQIVEDSLTDISDSWSYEQTEFSTEFSNNRDGTKEGAKNEAFLRSSEIQCEVENRQLTTELPSAKAKEECIDREPFLGDKLISSEASFADLVVDHPTHGTDDMTGNEAEQWRTEDKDLQKMGKSKSNLTEKELQTKKEETMQLSKKEITPQQAQESSNEIQDDVEKLLEHQLEENFTCTGVIPVVETQKVEEWNLPRFDSIAASEQSTSLSPKEKEFKKEQEIEVSQEPSLFLDQIQEYSNIITDVEYNKTNNDAKTKKLSVKEDQLKDQQWSEIREDNKFADQSQKPLKHSKETVTVAREIILAPADLTDLGIARVCDYTVKNDLRETSFEQLPDTGYLQLTYPAATEKCGEAALMQETVAEELNLKKKTDYNPTKDLNEPEQKDEEEIDSKETILPFLVETYQKGLMGEFESKMSTTNAQDKLYYTAMNSTSPADQRALFISADEQMNILLPENLYNVSENICRDRVSAENLRESMQTMILFKEDVQKEVPESCEIQPMVTSTSEIGLVENKGVSLDKLISEEGTSYKDNLDGTSHLLTGRKIDEKLKPFSTKAEHPHELTVDIAWTPEGKEGTDEKTGLEKQAFSDMEQLIMYPSKDAINIIMKEERATENVTKESEKSNFESGSDGDESCSEYESVQWEKSTDGFEMTSEKLTNKLMRESAIKKEKLIEQDKELEGQFTMKISEVGKEESESFSTYRFELGKNETESSEITLERNIFIESLTPQKWLKSRKENQEELAIQGQKISEENVDIKSSEMMNRDQKESEKVISAIDGDLELMKEAQTVQNDELETNEISGDIMMLQQSFSVSAGDDKKSLPIKGGFPENLTAKHDLIISFEENLEEDVHSKITTSSSCELSMEKQRKILVLDEEKEVEKHVASETFLDDDQKFPAVPQQSEDTHVLEKGSDEHKLSQQSIDEEFFKDLFAPAKAMESGAAAVFANSEALAASRSIEIVPMVEDQKSFLRSSSFDASNNSTEKIKEDKKMPRHDFKESEETVPGKQLQLTANEGRIVEVETAKNITLSNVSDKCIYEEKYPAEQKECHEFTFAKKEEAEEDASTSSFSSMPSTYAEDTQTESLKEVDRRIESLEGAAVVAQQWTEDEIINNKLNHSAEEKYRETKKDVFKMESIRDDDMKWKVEAIPESTSEVVFSEELLTLTEAPSSRQKIDKGSSEMDEKTKIARGTDLEANAEHLIDESMEKLDQTTSRSSSSYNLDSSVVKHSDSKSPPSKVTTIGNCVSQVQDEYETDYESDLKEKLKTLEEEAKKLKHPEGRNLLNEDGRNEDELNKQAAEIVDDIMKPVESLSRSESIYKTATATSKNGYETCLTSQEDTFDTAPGYHSQESEYTTANSEASSRFSEISEERRENATPIAVLSPVQSDRLFTASQDEEQEPYRQENVIDSKRSSPDMPDIELVSVEDEDDMEDILLASANGVLLVPDVDPGRPVSPIPPGFDEDENIISVATASDCSRKTVDLVRQVEIKVLDSIVEAPGDDILADETFPSWERDVPEPTIFQESMHEKAMDFGKEYFSDYSDLSGRTIHTVEKEDEAAGVRLASETVLCTESDSLDSLDKISIKSGSSGKKYSTSRRSSTSSRKSSHDEPQTFVERLTPELKMSWVEKDLEVESAKHSSLSSSEEYPTYMSESEQINPVEVELETVDEEPEEADSLNGRSVSSNGQGTDISVTVGKYKTVSSDNVSETSLQEFERIERDVLNKGESSLSGSEVELYVAGKLKTADGSTSSLAEFERLEQEVIVDGSPQDEVMILSDIREESEVEEMSIRDDDEEHDSISDIKAVPVEEDAQVTTPLASPADSIERDFENFAPETMGTSIDSLEINIAPVHTENELGGDSYLTEYEVIEKVHGEMHDSLEMIPQDKDSVLEGISLVELTNQNKQTLLSGDKMSKYQEDQEDEKDSLAGDDMNTLLHDYPTTLTTFETMQINEDGSAEIISRRVLTRVTDPIISHVQFTGTENEHRLRDLEREEEFETMDLEGNVTRTTLHRSAPSSSAGTSFLIFHIFKIFLHAVYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H189</accession>
    <name>A0A183H189_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WAP four-disulfide core domain protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1249</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000560">
        <property type="protein sequence ID" value="VDO28848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H189"/>
    <dbReference type="STRING" id="387005.A0A183H189"/>
    <dbReference type="WBParaSite" id="OFLC_0000124801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000124801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000124801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF95">
        <property type="entry name" value="PERLWAPIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="360"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="3">
        <location>
            <begin position="410"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000124801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59225" checksum="DAE13A3FC04743FC" modified="2016-09-07" version="1">SQSSGNRIVVKPGECPHFFGRTCINQCNSDSECGSTLKCCSNGCGRECVVALDPQPLNSLGKENDRYSNRIGKYPPKNYIKNQNCVTECIYDKECPSIEKCCDSDCGRVCIPPEKATEQENEEFPLTASWTLKLKNYEIKLGPTFLLTITNCIHLITAISRLPGKTLINGYVPKCTIDGQFENIQCDDSFFGVLTKKALKLLGPKLQEKLAYRIAQRRDCGAKLCSKMCHFGIKTDNEGCPLDNCKCKDLCEEIFVFIGLLNPYPNGSPMTLSNGVTALCTHTNQRSPYRWCHQNGFNSFGFCYSLPKWVLHSGNRAPVLSQSSKSSKSECRIAQNKQNAVSMECMLKCMLDNTHIQGTKVQQIGKCPKISQHHDLGTCVIKCKIDQDCGSIKKCCTYNCSAVCLFPIEVAACLHEVITHEIFGYGRAPKCNGKGNYEQIQCDGSICYCVDTLNGNEIPATRTALQTKPSCSERRLDCEPFACSKICAYGFEITSKGCPLCECRTHLRDGKRETKFIVKLYANSVHTNIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1N8</accession>
    <name>A0A183H1N8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1398</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000648">
        <property type="protein sequence ID" value="VDO29387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1N8"/>
    <dbReference type="STRING" id="387005.A0A183H1N8"/>
    <dbReference type="WBParaSite" id="OFLC_0000139701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000139701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000139701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000139701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25418" checksum="8FC360E11C2EB021" modified="2016-09-07" version="1">MCCAAGKIKFLNLENQQSREKFCVPDILPIQKIELQKQIGELRAAVDALENEKVDMVEKLSEAKQQGVKAVRCEEEEKRQKLKKEMESRRVKEREEDERLFQEMIMKNDEQWALKFKEQEEQMQLAIEEREMQKVAAVIEHDRKNENLGVQVEQLTAEKLHLKSVLDDMKERHRQQMDELCISIEANKERHQQEINEIKQTKEEVITTLKKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H356</accession>
    <name>A0A183H356_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1916</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001012">
        <property type="protein sequence ID" value="VDO31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H356"/>
    <dbReference type="STRING" id="387005.A0A183H356"/>
    <dbReference type="WBParaSite" id="OFLC_0000191501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000191501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000191501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000008">
        <property type="entry name" value="Metabotropic GLutamate receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="144"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="630"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000191501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="787" mass="87568" checksum="9108ED187239637F" modified="2016-09-07" version="1">MTVICTAGIPPHIDANGDGIGNYNIYQLNDMGYYQIKSLIKKKIFRGTQTYNFLLILKLFFRKGLKRWDGSLPLSVCSTNCPRGYYRAYQDQNCCWTCIPCDVSTSIIVNETNCVQCPLGYGPNEDLLACKLIPPTTLEYNSPWVVLPAVCSTLGIAATLFVVGVFIRYNSTPVIMASGRELCYFMLGGILLCYLVTFILISKPNVLICAASRILIGLSMSAIYAAILTKTNLLARIFLMQDARHLDCIVPSAQIAICFGIVSIQLIGSLIWLLIDPPGITVLFPSREETILTCKARASHLLISLLYNMFLIVACTLYAFKTRKIPENFNETRLIGFTMYSTSILWLSFGPIYFATQNNFKIKFSCRGNSPCQAVLCVTPTDTLALVLTHDVIVEITLYKHIRICRIGGVAATICNGGRVAAVHHPSIEIVQEETQVLFDMVQGPRVRASSDAVHVLGVEGTDPTTLVHSITDQEVRKHKNSFVATGKFYLRRDIDNTAVLFLNGIAGVNIFGLFENQHERCMTAAKQAILDQKGNQLNAIIQGVKVKHDMETGDTRIYCGRNFISLCVASHALTLHSPWVDINVDSCSCTRLRRGEQIIETDGNFLRVTQNNMHADFTLNNLQSTADSSPSNEIQMTSLCMCISMSGTVALCCFFAPKVYIAVCQPYKNVRTRQSAVGRLVNQQMRTSAEKNSVTSSQITQQYETISPIVKKSHATRNAKCNNNDISHRSNNSIKSENSQLLMTTPFQHQSSNNISHPDDELAKETIIYQNNAELFFEQLFANYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H483</accession>
    <name>A0A183H483_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2293</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001288">
        <property type="protein sequence ID" value="VDO32508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H483"/>
    <dbReference type="WBParaSite" id="OFLC_0000229201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000229201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000229201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000229201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10905" checksum="3646EE959B248490" modified="2016-09-07" version="1">MIEAGTKYAQQNRKIKAECSAGAHFMKFSVKTVPGSAIKTQPCRKSIVRQHISQRRNNQIADTFNSQQSISRIIHNVNFYFLYLFWIFQYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4L1</accession>
    <name>A0A183H4L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2421</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001391">
        <property type="protein sequence ID" value="VDO32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4L1"/>
    <dbReference type="STRING" id="387005.A0A183H4L1"/>
    <dbReference type="WBParaSite" id="OFLC_0000242001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000242001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000242001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="287"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000242001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44542" checksum="57157A12B25AF889" modified="2016-09-07" version="1">MARRNHRRSKVTRVINLIKRIIAFFFSHVGLCALVIGYALLGAVVFRAVEGPHETFIQSQVTTARQKAVNIAWNATFRYLSLHPIHQGKIIVAVEPRKVNKLDREQWERIVHTQVRRFQRKCMWAIKRGYDGKEYGLSAQWTFTGAFLYSLTVITTIGYGNTSAKTYFGKTLTILFAIIGIPLMLLFLTNIGDVMAKIFRFFYARSIRLKYRLILWHKRRKAAELRHANSVVSRFVMANLSGDLFRTAHNMQDLLTARAQIEQLEVKESVEAQLQRISVPLSLVFFTMFAYLVAGSVLFCLWEGWTFLDSFYFCYISLTTIGFGDKFPGASVGNDKDAQKKLVITSVYLLFGMALLAMCFNLAQEEVVNKVSWLANKFKSRDDDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H589</accession>
    <name>A0A183H589_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SORBS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001562">
        <property type="protein sequence ID" value="VDO33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H589"/>
    <dbReference type="STRING" id="387005.A0A183H589"/>
    <dbReference type="WBParaSite" id="OFLC_0000264801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000264801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000264801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000264801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19818" checksum="723A15B998CD6B4D" modified="2016-09-07" version="1">MDTSCQQTYSTDQQQQLMTLYDPQIPTTSYEPSSLSNIPQPHHPASYYDSSMSHYPASRVPYPSISVPNSPMRTQIKCEPQQLSQPLPQPQYPERMVSTVDNRKIMNTQAWMNDHRFINYPHQQQYRTGSAPSSVMSMSRMSHVSSATEDMSMLSVNTQITELRQLADLVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5G0</accession>
    <name>A0A183H5G0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2720</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01001630">
        <property type="protein sequence ID" value="VDO33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5G0"/>
    <dbReference type="STRING" id="387005.A0A183H5G0"/>
    <dbReference type="WBParaSite" id="OFLC_0000271901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000271901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000271901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="358"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="642"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000271901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="753" mass="87609" checksum="6DD96F8DD1622D38" modified="2016-09-07" version="1">MAAIAPAVQNLNSNSYTNGERTCVETLNEVKKDMSNDDDVPLSRKVRMIIDDDDIPLAKKLKSMKRDDDDDDDVPLSQKAKVVFHICISQKPEEALAASSSSRVKKSHSSTKKVVKTELESDDDVPLSVRAATLTKKRRKNESDDEDYKLEKKKEKRKNSSERKKASTSSSSEKIHIKNEKANGITSNKRKKREEEEEEIWKWWEEEKKPSGIKWYSLSHKGPIFAPPYVLLPESVHFKYDGKVMKLAPLTEEIASFYAKILDHEYTSKETFNKNFFMDWRKMMTPAEREKITDLTKCDFREMHAHYVKLREERRSLSKEEKQKIKEMKQEEAKIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHPKMGRLKRRINPEDVIINCSKDSEIPKPPEGHRWKEVRHDNTVTWLCSWTENILGSIKYIMLNPSSKIKGEKDYEKFETARRLKGIVGSIRENYTKDLKSKEMRVRQRALALRAGNEKDVDEAADTVGCCSLRCEHIKLHEKLDDNEKLNGVTFSYVVEFDFLGKDSIRYYNKVPVEKRVFKNLKLFMENKSGNDDLFDRLDTASLNKYLQSLMPGLTAKVFRTYNASITLQQQLEKLTKDDSTPPELLLCYNRANRQVAILCNHQRAVPKSHEKSMENLGTKIKTKKAELKEAKEELEKARGDAAKQRASKRIDRIKEQLRKLKIQRTDKDENKQIALSTSKLNYLDPRISVAWCKKYQVPVEKIFNKTQREKFRWAIDMADEDYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H608</accession>
    <name>A0A183H608_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3302 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001812">
        <property type="protein sequence ID" value="VDO34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H608"/>
    <dbReference type="WBParaSite" id="OFLC_0000291801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000291801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000291801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000291801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11452" checksum="5FCD6BB4507268E5" modified="2016-09-07" version="1">MLIIYWMLIPAFIWIAIILFMWKNLRYHWRKIIIPLATAKHCEVSGNLLNARNEIVTMPAWDGILEARFEQTTQSEHDEIDWSPEENPAEMQNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6B8</accession>
    <name>A0A183H6B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Upstream stimulatory factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001900">
        <property type="protein sequence ID" value="VDO35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6B8"/>
    <dbReference type="WBParaSite" id="OFLC_0000302801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000302801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000302801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000302801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="5472" checksum="7CD5B7CE31BFCB00" modified="2016-09-07" version="1">MTMQTGDHSGSVPVSVRGIDCTTPPVTATATAMIAAQTSADGNSMEPNFTNGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6F9</accession>
    <name>A0A183H6F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLASP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001935">
        <property type="protein sequence ID" value="VDO35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6F9"/>
    <dbReference type="STRING" id="387005.A0A183H6F9"/>
    <dbReference type="WBParaSite" id="OFLC_0000306901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000306901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000306901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000306901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19972" checksum="DABA533AC4FB6834" modified="2016-09-07" version="1">MKDAHRYQKIVLFSGIYNLRPLLDTYIGKAINLNLAEAEALSVVSLDKIAAELLIVVGSDESPKFKEQSQYIAEKYVEKYHAMNISDCYKISLSTMKNERIDETQSTKESLSEKKEEMEEDSFAKKTPIKRLARRSFEIRLKPPVDKEREDYKTFTAIKLPMSETMGDSDFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7A0</accession>
    <name>A0A183H7A0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">39S ribosomal protein L38, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3362</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002224">
        <property type="protein sequence ID" value="VDO36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7A0"/>
    <dbReference type="STRING" id="387005.A0A183H7A0"/>
    <dbReference type="WBParaSite" id="OFLC_0000336101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000336101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000336101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF133">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000336101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42448" checksum="B3044C506988D8DA" modified="2016-09-07" version="1">MKRAPRSIYADIFVKDAHRIKGTPRVARPWRPKVIAWAGPAAFYRNRFYEPNAWYKARITKPVLYPKMHVIDPDNHLLSLKKRLAVPETQRYDIGFKKKILLPIPSPPSESKNALNLSKKMQLTIDLKKVEHWQLSIFHHYRIFDDLFHANVFFHNTQNMQLKWDNIGLYQGNLIDAANTSNKPDISIESIGDGFNSFILLNLDGNPYNCDGEVVHWLVANIPDGKSVINGMEIIPYLQVVPFKGTGYHRIACLLLRHKEAINLSSRKPKSVALIDRIFSVGQLYKEFEKQWTPSAFSFAQASWDISVNETLHRIGMKAPIYEYQHNPPVKMDQKEFPLKPQPFNLYVLYINFRFSNLGVSIRQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7U2</accession>
    <name>A0A183H7U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002412">
        <property type="protein sequence ID" value="VDO36939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7U2"/>
    <dbReference type="STRING" id="387005.A0A183H7U2"/>
    <dbReference type="WBParaSite" id="OFLC_0000355301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000355301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000355301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000355301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25630" checksum="99F2C06114561BD4" modified="2016-09-07" version="1">MDRLEAAFVLCNDRILKCCKTININWSKERSAELKEQILGIRNYANHIRKLIHDRMHNFILSMISNRVTFYQQRFPPGLSIIHAELSALTARFTRIVNHNRETFGLYYGQTTFDNSAKRRSLSVPHYQDHLQRSDRRRCTIISYSANGLHKQDELSSQTYQGQREFYKVEKNSKPGNDIQGKKVMFEKRESGKINFLGSFNAFFSFITDRTLQKSPNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8B0</accession>
    <name>A0A183H8B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3722</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002591">
        <property type="protein sequence ID" value="VDO37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8B0"/>
    <dbReference type="STRING" id="387005.A0A183H8B0"/>
    <dbReference type="WBParaSite" id="OFLC_0000372101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000372101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000372101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000372101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42848" checksum="981D131D8DD06DB3" modified="2016-09-07" version="1">MNGPLHVCFRLLFYAEKANSSTEIWHEMIGRNFDAKKLCVFAWYLIERGQQPDVGFDDRKVGLVGSRLYISLCCLSGAQAFNIFNDYLFQSALEELRLIRRLLSNNQLSTTHNRIEISTKSKNKKPFRNNSRTKQTDFEQLTLEDATELRYMLCDVLDSLFVFLNRGLISSTQQSLVSLAIFLQQLMQLDFSEKSSVLSCKQISDFQRLKAFSDRSFALMHRFLDNRHAAPGVVYGRIVMPRLLFWTLENTVFPTNAHPPKLMTTYKEAMHNFIRIRMQKGSDEEIFTILLLLQNVCFRCPDRSDYRAKVAGSVVEILAYLSPRYIRDFAAFLLLTSANSKVAVRGFSVEIAVPFIKQYGKLPAFDLAKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8N9</accession>
    <name>A0A183H8N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002715">
        <property type="protein sequence ID" value="VDO37971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8N9"/>
    <dbReference type="WBParaSite" id="OFLC_0000385001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000385001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000385001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000385001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11379" checksum="CC786969F030E69A" modified="2016-09-07" version="1">MVVNESSLLAGQISEKSVQKAQNIKEPKFPATTQSTETGRVTGNNSSINAATVPLTVTPINGSFPLETSSKSSDSTSTIISTAPLSTSTAAPPTTIETIAPPKSTLSQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Y2</accession>
    <name>A0A183H8Y2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3943</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01002814">
        <property type="protein sequence ID" value="VDO38311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Y2"/>
    <dbReference type="STRING" id="387005.A0A183H8Y2"/>
    <dbReference type="WBParaSite" id="OFLC_0000394301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000394301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000394301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO38311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000394301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11907" checksum="7EB9CB017ADA7F1B" modified="2016-09-07" version="1">MKIIYYKGIKSMHFNFLKKIKSKIEQLISLLKRFVRAHQVVQDGYEFFANRKLVTIFSAPHYCGEFDNAAAIMTVDNQLLCSFDVLRSTNNPIRIQLYGNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9X5</accession>
    <name>A0A183H9X5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein AAR2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">AAR2 splicing factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4286</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003189">
        <property type="protein sequence ID" value="VDO39523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9X5"/>
    <dbReference type="STRING" id="387005.A0A183H9X5"/>
    <dbReference type="WBParaSite" id="OFLC_0000428601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000428601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000428601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO39523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000428601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27367" checksum="C56FB0819D87CCE2" modified="2016-09-07" version="1">MLALIEKVRSNLKSMDDGLAPYPFETYLSWFSLSNYITEKTVERLRPENQCSRITGQAELITLETEMMEKEGVHGHPSSCVDRDHPLRIRFVDEDGLPIMKIRDGFQIRFTELPLCSVAVSIKAEKPLDRSWQLHKILADLNGEWFEFLGELQFAFVCFLMGQVYEGFEQWKRLIHLLCSCTKELIEYKELYMALISVLHFQLKECPEDFFVDIVSRDNFLTTTLSKLFGNIHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAB2</accession>
    <name>A0A183HAB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003349">
        <property type="protein sequence ID" value="VDO39963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAB2"/>
    <dbReference type="STRING" id="387005.A0A183HAB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000442301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000442301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000442301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000442301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49347" checksum="389738CF2E599438" modified="2016-09-07" version="1">MIEFWNVIGTPIFHVRSTFLGNKTAESLLWKGDILFAAHLDGSITSHRLHTSEYFTSRLTPSPLWCLASITGSSFCAGSDSGTVLILSVEDNDHVVLNKTISIGFGTHIMSLACNGNVIAAGTMDEISLISVPKQLIEHRIKLPRIEKRKPTIVWCLCFIDDYLVSGDSRGYVSFWNASNGAFSHCLQTHQSDILSITAVNESLYAAGVDPTIARLGLNQERTTYRVEHRRTIHTNDVRALAASQHTTALYSGGADYYFCVSNRFKHADALKNITCNVAAGANLFSYQYDDRIVIWEAGKPSTGASKKGIYCLANGPIKIAQLRSHRGDFIRSSALNHEGNLLAVSTICTTTLYKLDLHSSKEPSISVLKRIDICGTELLFTSTSLFIASGCLRISSLSIGDSISEYPDLITERDNAGEVVRLHSNMTETFLVLLTARNELFTLEIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAS5</accession>
    <name>A0A183HAS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DCB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4587</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003552">
        <property type="protein sequence ID" value="VDO40419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAS5"/>
    <dbReference type="STRING" id="387005.A0A183HAS5"/>
    <dbReference type="WBParaSite" id="OFLC_0000458601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000458601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000458601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000458601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20050" checksum="002C1953D4CCE56F" modified="2016-09-07" version="1">MQNVQDSSKLGAINVLRHLLNSAGPYVEDKRSLVILGLKPMLLAGSEGLLSIRVKKAMCQLCVALADHEYIDVEGGDNVIIFLVKNLIVQEGEMTKKAFFSSETEADGAAHLRAQCGQALQTIAKTSSTAHSLLWPYLFEFICAQEYSIALTDIFKCIRILAERTIKAGEKPNFETGFDSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBL1</accession>
    <name>A0A183HBL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4873</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003917">
        <property type="protein sequence ID" value="VDO41311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBL1"/>
    <dbReference type="STRING" id="387005.A0A183HBL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000487201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000487201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000487201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000487201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44305" checksum="50CB472A3E78E9C0" modified="2016-09-07" version="1">MTTTPVKKKVQVSFVIRDEKEPMHRSGVNCLQYDAQTGRLFSGGSDTIIRIWKSPDRINDSLRVAVKFQILISKEGPVSGIDNSLINKRTKIRHDLHLQSMEHHTDWVNDIVLCCGGRNLISASSDTTVKVWNAQKGFCMSTLRTHRDYVRALAYARDVEMVASGGFDQLIYLWDVATLTKLTALNNTVTTSSLNGNKDSIYSLATNPSGTVVISGSTEKVLRVFDPRTCQKLMKLRGHTDNVKAIIVNRDGTQCISASSDGAIKLWSIGQQCCISSLKCHSESVWALQADSSFSYVYSGGRDKRVFRTAINDFKTAKLMFIEDAPIQRLQLTEPESRFIWAATWNSSIKRWPLLSDVQISVGMKNDQYGEMIPCIHEPDVTIPGSEKMPKFSIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBW0</accession>
    <name>A0A183HBW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rtf2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4971</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004058">
        <property type="protein sequence ID" value="VDO41630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBW0"/>
    <dbReference type="STRING" id="387005.A0A183HBW0"/>
    <dbReference type="WBParaSite" id="OFLC_0000497101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000497101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000497101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000497101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14992" checksum="F20756AAFEF5898C" modified="2016-09-07" version="1">MGADGGTIPKRCELVKKKKKKEKLDKNVANATRWRLCRLSQEPLKRPIVACRLGNLYNKEEVLNAILSKRIGEYEVAKHIKGLKDIKELKLTNNKEYRESGADKGDIYKDHNIAPFCCPVTGISMNGNYPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCC9</accession>
    <name>A0A183HCC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAPA-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004268">
        <property type="protein sequence ID" value="VDO42173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCC9"/>
    <dbReference type="STRING" id="387005.A0A183HCC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000514001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000514001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000514001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000514001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17772" checksum="66474C803F41D9AC" modified="2016-09-07" version="1">MSRNIVRKSDYGAPPARMSAGAPPSLPVRRASKGGFRNVRLTSSINRKRRSEGNLETEDSDSEQASTADDQEENGSGDDVKKEEQEEKIKKTPRKKRRFRLTDSIAKSKRRAERRAQLAAVRKEREESKQQQEDEISDEVKEHSSTPPPLPKASAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCI8</accession>
    <name>A0A183HCI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5200</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004339">
        <property type="protein sequence ID" value="VDO42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCI8"/>
    <dbReference type="STRING" id="387005.A0A183HCI8"/>
    <dbReference type="WBParaSite" id="OFLC_0000519901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000519901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000519901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000519901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42129" checksum="35E0B267C7128AD9" modified="2016-09-07" version="1">MSDSNKHLIRSPAWKNPRDVIRKGIHRNKRGSSVSSSSSSSSSLKQLFVDNEADEGFSMLSTKTSQGADSIIINPFRRASCKKVFGRNSIPEKVNDDNNNISSMVDLIADSNALQEFPSIVFDRMKEISMPNEIEAKSTTIAGSTTTTSNVESLPVDFSSIDEFSCSTPKKKALKVDELKTKVDSLPVDLRLGLKLRLESPKRFFWLEKSKRFADYDDAIKLFCSLQTETNEIEATGRSISNISKFLACTLYWQFPDLAWQPSFPRLDNDSRLITGRKPAVPSLHTLGDSLVQALTMQFLSFEQLYHSWRFGKRSYFYACCPTYTILFWKTSKGIVEVNENLSESGEKYNFRVVITPTSYGFRQQLREEGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCL1</accession>
    <name>A0A183HCL1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5224</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="EMBL" id="UZAJ01004373">
        <property type="protein sequence ID" value="VDO42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCL1"/>
    <dbReference type="STRING" id="387005.A0A183HCL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000522201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000522201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000522201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000522201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39349" checksum="221C30EDD370A913" modified="2016-09-07" version="1">MICVNNGICYKNDSNNLQFFLIGDTGGLPIYPYTTYAQKLIAKSLAKIGDKKNIEFTISAGDNIYFTGVKDEFDERFQESFENVYKGKALEKPWYLIAGNHDHFGNISGQIAYTNRSQRWCLFKTYPASYYKVSYAFGKNATLVEFLMIDTILLCGNTRDITEAGFIDMIFATVQKNPNTPKDPVAAKTQLDWIEQQLNSSRADYLFIVGHYPLYSISEHGSMNCLIEKVKPLLEKYRATAYHIVTEHSLASDNVEKIQLHYIVSGAGSRSDHSVKHMDTVPEGSLRFNYPTGFNPVSQLGLSTGGFICADMDREKAIFTFYNGKGKQKYSCVITPRKKFAVGEGRNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCR4</accession>
    <name>A0A183HCR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5278</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004453">
        <property type="protein sequence ID" value="VDO42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCR4"/>
    <dbReference type="STRING" id="387005.A0A183HCR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000527501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000527501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000527501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="216"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000527501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46657" checksum="FE77AACDD139EDD9" modified="2016-09-07" version="1">MTVADYFGERYSKLKYPKLPCVHVGPVTRNIYFPLEVCMLDTPQKYNKKLNDKQISAIIRAAAVDAVSREQRIASLCKQAGFQCDPFLHEFGLQINPKMYEMIGRVLTPPRILFGENNRKTDPIVMPKDGVWSMDDQRLYLPASCHSYSMIAMVNPREQNHLQAFCQALTQKANQVGMEFPNWPDLVKYGRTKEDVVILFNEIATEYKQTGTSCDLVIVVLPNKNADLYMTVKECSDMIHGIMSQCILMKNIMRPSPATCCNMILKMNMKLGGINSRIVADSITQKYLIDVPTIVIGIDVTHPTQHEERQNIPSVAAIVANLDLYPQSYGANIKIQRKCRESVVYLLDAVRERLVSFYKTTHQKPIRIIVYRDGVSEGQFSEVLVTFLYEIINVFIGKQKRKNLVFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDX8</accession>
    <name>A0A183HDX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHTB1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5690</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005025">
        <property type="protein sequence ID" value="VDO43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDX8"/>
    <dbReference type="STRING" id="387005.A0A183HDX8"/>
    <dbReference type="WBParaSite" id="OFLC_0000568901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000568901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000568901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000568901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42675" checksum="3ECA597F4513CA84" modified="2016-09-07" version="1">MSVFHVHEWLALDLIDANVCAVGELIENRDQIVVGSVTGRIWIIDPGRANDTKQQQLLSCLLEEDLSVSIIDIAIANFVSNLEKNVIAVLSPQKLIIYHLVPDEEAYQLTKLHEHNITAIAYNMCIGKFGRSLTTQICVQDMTSSLMVFAAENPLFHHTIPLIPAIHPGPIVYAAYSDSIVTVSSSTGILTSYRYSVLSAALSGKKITANWTFNLGDYPLDLETIDTALVQPSIVILCKRTIFCFTHGGSLRFTYRLQCVATSLLVYDSADDAYVKLCISTATRLLLFFKNTISIWSAQLSHNAIQVRLCSFSSYRSMLVILSNSRISVSYLGTEPSLFRIPAPQTRYINFQQRYNEFMELEAIIRKKPTDLTDGLEFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEH6</accession>
    <name>A0A183HEH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5888</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005310">
        <property type="protein sequence ID" value="VDO44683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEH6"/>
    <dbReference type="STRING" id="387005.A0A183HEH6"/>
    <dbReference type="WBParaSite" id="OFLC_0000588701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000588701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000588701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO44683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000588701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8332" checksum="23956EE41BE8B6CE" modified="2016-09-07" version="1">MERRPDIVLPCVHTFCSVCIEQWKAMEKNWCPLCHNSLEFNGSDIWVIPDVMESGELKNYLMSLTKSDGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEP1</accession>
    <name>A0A183HEP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TORC_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5952</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005395">
        <property type="protein sequence ID" value="VDO44904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEP1"/>
    <dbReference type="STRING" id="387005.A0A183HEP1"/>
    <dbReference type="WBParaSite" id="OFLC_0000595201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000595201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000595201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000595201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12539" checksum="D53F6F6A4AA7F5FB" modified="2016-09-07" version="1">MIRGGAPAPAQRGSGTSSLPSNVRDNIMHRLMLSTQAGGVTNGSGRAEQRSQEEMQQYIGRNFPSHTFQAPQVSSDIMDLWPNVSGAENFPPPISKTCFLNLLILKILKNFLVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF73</accession>
    <name>A0A183HF73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6135</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005669">
        <property type="protein sequence ID" value="VDO45543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF73"/>
    <dbReference type="STRING" id="387005.A0A183HF73"/>
    <dbReference type="WBParaSite" id="OFLC_0000613401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000613401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000613401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO45543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000613401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19768" checksum="7B9D713651DF6173" modified="2016-09-07" version="1">MMFQRVVDIVITCNKMTAAARLAVRKALEAGQSVSSRFDPDELIISAMLIACEEGNLAGLDQLAVLHRINLNIANRVRFIITKNAVLQMGETAMHVAAGAGQFDIVHYLHMKGAALDACDRRGDTPLFWATRNGHNNIVDYIINEENVNINAVNKSKESVLHVATRYAQLGSVLRLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG61</accession>
    <name>A0A183HG61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor SYF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6473</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006167">
        <property type="protein sequence ID" value="VDO46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG61"/>
    <dbReference type="STRING" id="387005.A0A183HG61"/>
    <dbReference type="WBParaSite" id="OFLC_0000647201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000647201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000647201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000647201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15370" checksum="B38D2076F046ED76" modified="2016-09-07" version="1">MGKSKKLKSNAGDLVSKSALPLDLQIERSKRESGRDVARVKQRRLKRANQDDDKYIDEALSSKILKTAWKQKQDIEAMGETKPETAMQKDALERMRKVSLGNDSLNSLSDDDIVSDHDDYDDAVLVSIYFLDVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG99</accession>
    <name>A0A183HG99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006219">
        <property type="protein sequence ID" value="VDO46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG99"/>
    <dbReference type="STRING" id="387005.A0A183HG99"/>
    <dbReference type="WBParaSite" id="OFLC_0000651001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000651001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000651001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000651001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29675" checksum="2DC264E9CE75593F" modified="2016-09-07" version="1">MDLCKSNNSFTVGCSKCTSLCGKRLPCGHDCLRICGAPCEPCTAPCSNQCQHSYCGQQLDIMLLCAALHEQLQTSKMSNAMLANVCTKCQGISVPVLQFQGCKCIVSVEEADLHIQGQISRKQQYTCPKCSCRLSANSCFRYARELKEQVIFNERIKFSKLLINGSLIDLQYNVLKQAEDDLAKIMKMKGKKKDTIVIEITEILHLVIMRLNTEFYNQLGIMKWQAMHAFRFMPVNYVYYHRKVHFYSEEALFQLAYTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGW1</accession>
    <name>A0A183HGW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6724</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006562">
        <property type="protein sequence ID" value="VDO47673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGW1"/>
    <dbReference type="STRING" id="387005.A0A183HGW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000672201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000672201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000672201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000672201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8026" checksum="4F77F542FFB7736B" modified="2016-09-07" version="1">MQVSEDWSYVSMVLDRLMLMIFSVINIFGTLIILLQSPVLYDSRPPMTINPASKPLSGDTLELFVNSSYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHY2</accession>
    <name>A0A183HHY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7094</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007162">
        <property type="protein sequence ID" value="VDO49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHY2"/>
    <dbReference type="STRING" id="387005.A0A183HHY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000709301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000709301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000709301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000709301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="37404" checksum="411E3261A8909A50" modified="2016-09-07" version="1">KKSRKFILKSVSFLFFRTTNQHSSSPRVIVPLRRRPPVPQTWFEWTITIIKLPFFIVYQSLFDLLGFIWSLFRAPPLAVADSRGDVRHFIDEFNTRFGDSTNGIRFFSGSYDDAINECKNSLRFMIVYLHNPSHESCDRFVRETLLSYQMKQFLDRNDILLWGVSVRSQEGYKVSMALRENTYPFLGLLCMRETRMVLILRLEGEYELEPMLFTIQTSIDENRSYLDAIRNERHQREVNNRILREQESDYQRSLAADRARLNERKRAESERKMAEMKKAEEKKKEQEKKEVILFHLQYIINYREFITMMIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIK8</accession>
    <name>A0A183HIK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">39S ribosomal protein L59, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
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            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007555">
        <property type="protein sequence ID" value="VDO50395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000731901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000731901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000731901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000731901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17666" checksum="34E30F8A3F9036FC" modified="2016-09-07" version="1">MRLTIWLRRNLNLPEWNRRVWEIGYRGPPLPKVKIKGRPDYPVNNNAIRQLQDRMKREYEVMKCLATPYLDKEMEHEYIKKYGTAEEQREKEFLEMEQRRMPGKPKKKIVGTGKVLKARANVGNLLHEHRTIENSLKELIIRQRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ35</accession>
    <name>A0A183HJ35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007866">
        <property type="protein sequence ID" value="VDO51248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ35"/>
    <dbReference type="STRING" id="387005.A0A183HJ35"/>
    <dbReference type="WBParaSite" id="OFLC_0000749601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000749601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000749601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000749601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="24081" checksum="DD3B4A7FB3DE428C" modified="2016-09-07" version="1">MRSIIEKFIIQKAAEHNCLLDCWNISCHRQSDLSLRTKDYILSYVMQSLEEAILDLRFAQLDQGAVEALLRCQNLPVRSECDVLRIALMYYLRRNGHVNMQSLLNVVRYNCGTEVLMRMRQDIHYVDDEEIRFCFEQNCAYGLWQAERHTYDPNIWPITEILPPRGNPNADCDWITAQFYSLVRYTTEPFRYTILRPTTEPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ82</accession>
    <name>A0A183HJ82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRP15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7543</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007951">
        <property type="protein sequence ID" value="VDO51467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ82"/>
    <dbReference type="WBParaSite" id="OFLC_0000754301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000754301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000754301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000754301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10591" checksum="1F3757EA029EBD28" modified="2016-09-07" version="1">MEEEKKKKIKLGKKKVDVVTRITKKIGKAAEVISKVISKDRVKEEKEKETGSTFRLGRFGAQFFAPVSRPSDDSIIDDDDESDGEDVESEQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJN8</accession>
    <name>A0A183HJN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCDC92 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008210">
        <property type="protein sequence ID" value="VDO52225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJN8"/>
    <dbReference type="STRING" id="387005.A0A183HJN8"/>
    <dbReference type="WBParaSite" id="OFLC_0000769901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000769901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000769901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000769901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25153" checksum="3DC0834C5549547A" modified="2016-09-07" version="1">MHDIFNPYHIFQYSWKCQIIQKEVILDEEYNEEDDDSIQSLIQRHRLELELLRERQRRELQLARLRLRHNQPGNGNTLVTTGGGCLTRSIDSCGSGPQDPIHIPYHSLASSRINPHLKLPLSISLPGSPPQNSFLGQHLESLRDTLPRRSYMVTSLAECARHTSVDAALSRRPTYPSAHCSSHINNNVADQHRHQHHHYHHYHHHHQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLC0</accession>
    <name>A0A183HLC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8281</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009230">
        <property type="protein sequence ID" value="VDO54931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLC0"/>
    <dbReference type="STRING" id="387005.A0A183HLC0"/>
    <dbReference type="WBParaSite" id="OFLC_0000828101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000828101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000828101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000828101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24564" checksum="2AAA2DE55F7D0CB4" modified="2016-09-07" version="1">MHNNGLESLTNNWVIFESKSPKGFKKKLDREVNSREKEVSSRELSDSSERFSSSNTSPILLKVRDYLDDDVRSTAAATSNSRAKQVACNLSEVTNTMELTAIRDSGTSISGGSGLTTEAEIPRPVAIKLSNLTGQFTSQQFLNFLFSVKDDKPILDAIEAVLNSCRSYRAALEVPLPKTLADLRRNLKFRKLFSIKFCSIHEAVALLQTLIIQRHEAKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMF8</accession>
    <name>A0A183HMF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8667</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009999">
        <property type="protein sequence ID" value="VDO56821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMF8"/>
    <dbReference type="STRING" id="387005.A0A183HMF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000866901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000866901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000866901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF149">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO56821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000866901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10701" checksum="F64EDA8CA597504D" modified="2016-09-07" version="1">MTAHRVNFNLAKYHSYPEIINYLSQLADVYPDRVKLMSIGVTHENRQILLIKIGRPTQLRKPGIWIDGGIHAREWVSPTTVLYMINQRESIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMR3</accession>
    <name>A0A183HMR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mic1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8774</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010203">
        <property type="protein sequence ID" value="VDO57330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMR3"/>
    <dbReference type="STRING" id="387005.A0A183HMR3"/>
    <dbReference type="WBParaSite" id="OFLC_0000877401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000877401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000877401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000877401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31409" checksum="7835EEE8482B5453" modified="2016-09-07" version="1">MGDAWGRLGVWDLGQRQCHQTRSTSRGPILKLVFSRVPNDHTLAVLHRHTVVLWDSEQLLVLQQCNSIDTSVSFLDIDLYGMYPLVVCSDNSFRCIPFVSSEVRRHSDLPVLLEIDSSQLLTTVVNNDSKIMLLHELLKLNDKIPFDDNNLHRYPIVHRFFGERWLYDLWLVVISTLHDTPLSSRLQIFWSPFYLKRRVEQLLACLMSLPDLNSVQIDILVHLAIVLQKRDWAMQLLLGSHEECRTSALRACLLASDVSSEGARSIIKLVATNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN82</accession>
    <name>A0A183HN82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010521">
        <property type="protein sequence ID" value="VDO58121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN82"/>
    <dbReference type="WBParaSite" id="OFLC_0000894301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000894301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000894301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000894301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4090" checksum="8C598F8AF0B8A26F" modified="2016-09-07" version="1">MVEQGKLDCNFPTFEPLNYLRLATAPVAAKYPLHAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPJ9</accession>
    <name>A0A183HPJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9412</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011501">
        <property type="protein sequence ID" value="VDO60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPJ9"/>
    <dbReference type="STRING" id="387005.A0A183HPJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000941001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000941001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000941001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000941001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="30217" checksum="2024ABE4060747FB" modified="2016-09-07" version="1">MEKQGEIVLDISISFYFSSFFFILGIAKTHAQRRHLKVETERVENIERLRNLPKRSEIEKKMRDDALAKPVSENSKGFLLLSKMGYKPGMSLGVEKEGCSEGIKVPIALELKTDRTGLGHDTEEDEKRKQRIDLYQKAVLERAKAHEVLIDDFSVRKRWAARMKQLSKDLKKSRKVCQELDARNGLEVPTSHHFWPIYKVMKEEETSLVKKRRIEESESITESFTYFNGKIAPDDLEIDELSENEITELYVIFETYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQI7</accession>
    <name>A0A183HQI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PARP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS9746</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012295">
        <property type="protein sequence ID" value="VDO62948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQI7"/>
    <dbReference type="STRING" id="387005.A0A183HQI7"/>
    <dbReference type="WBParaSite" id="OFLC_0000974801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000974801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000974801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070421">
        <property type="term" value="C:DNA ligase III-XRCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO62948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000974801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23722" checksum="407AF1DFEF42755E" modified="2016-09-07" version="1">MWRMVPNPFTADTGNPTEMKNYFHADCLFETLTRCRATTKIIDSPDDIEGWDLANDDDKQSILEKIRDLSELRLKKFGDKVKISTSSPSKDTTPKATTPKDVSLKKAKDDKTKTDKHSRKKAKYETAEKDPEEISSVKASSSKTKISNIKNEPSTAEISKSEDGIQKMGSKFDVFKLFCKLCNVIASVSKYTEKTEAVKIFINKGMIKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR29</accession>
    <name>A0A183HR29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9942</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012731">
        <property type="protein sequence ID" value="VDO64621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR29"/>
    <dbReference type="WBParaSite" id="OFLC_0000994001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000994001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000994001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000994001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13815" checksum="48AC4732C325B66C" modified="2016-09-07" version="1">MSNMWGHTSNAYTRPNDTLMKPAGTEFQKHALRHLYVNSPPSTSLPHPFHLNPRRTEQKPSQRRNAFSRGVDVNRRGMKTSVYRMIICGFLVGMKLKRNANSQNNTIFTIYLSRKPRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRA4</accession>
    <name>A0A183HRA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10016</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012907">
        <property type="protein sequence ID" value="VDO65176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRA4"/>
    <dbReference type="WBParaSite" id="OFLC_0001001501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001001501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001001501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001001501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10766" checksum="0B83D5AADD817041" modified="2016-09-07" version="1">APLFGGIINFDSVITDINPSYNDVVRPKQYTEDMAIRAMSIQTSSIIDFWIENYIHDIYNFIVFMCNFNRTIIIATMKDMPIYYDMQPNVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTM6</accession>
    <name>A0A183HTM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS10838</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014910">
        <property type="protein sequence ID" value="VDO71729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTM6"/>
    <dbReference type="STRING" id="387005.A0A183HTM6"/>
    <dbReference type="WBParaSite" id="OFLC_0001083801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001083801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001083801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF341">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO71729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001083801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17611" checksum="5E7BAEDC6043BAD2" modified="2016-09-07" version="1">MGLIPVLRVVVPQMLIIVLLIVYIFFGSVMFIILDEKLAEKNFTDIILFSFTTIATIGYGNITPSTPLAQLFCIVFSILGIPMTLLTLANLGKYLTKSYWMLLVCFGKEMRWRPCENAKMPLPTVLVLFLITFAFGSILFYQKGKGFSIDDIYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTP4</accession>
    <name>A0A183HTP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10853</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014951">
        <property type="protein sequence ID" value="VDO71849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTP4"/>
    <dbReference type="STRING" id="387005.A0A183HTP4"/>
    <dbReference type="WBParaSite" id="OFLC_0001085601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001085601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001085601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001085601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21816" checksum="F5972050C9377794" modified="2016-09-07" version="1">MFLRLMYQKAILATNFQIIIFKGADKHALVWDIRTGQCVQSFEGHEADINTVRFHPNGDAFATGSDDASVGLSFFYFPFSIDSFLNIRICIAFCRLFDLRADRQVCIYEKESVLFPVNGVDFSLSGRILFAGYGDYRVGIWDSLKCVRHSVLYGHENRISCLRTSPDGTAICTASWDCTIRVSFFLLKSYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUA7</accession>
    <name>A0A183HUA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11072</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015517">
        <property type="protein sequence ID" value="VDO73574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUA7"/>
    <dbReference type="STRING" id="387005.A0A183HUA7"/>
    <dbReference type="WBParaSite" id="OFLC_0001106901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001106901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001106901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001106901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7640" checksum="2C9B8FDD7E84ECC3" modified="2016-09-07" version="1">MACLLLASKIEEAPRRPRDVINVFHRLEHLHGKRNESKKIYANLKKRTIGHAMDAIDTKDGTSEAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUW2</accession>
    <name>A0A183HUW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016073">
        <property type="protein sequence ID" value="VDO75228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUW2"/>
    <dbReference type="STRING" id="387005.A0A183HUW2"/>
    <dbReference type="WBParaSite" id="OFLC_0001127401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001127401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001127401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF103">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001127401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9437" checksum="3FD4703BFDE5CC88" modified="2016-09-07" version="1">MRFLERIYQRYGRYIAKHPIPFMVLPILTTLFSTIGLPYFHMDNDIWNIYSPINGLSRVEEKALERFEYASSVHHYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVC0</accession>
    <name>A0A183HVC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11431</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016501">
        <property type="protein sequence ID" value="VDO76410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVC0"/>
    <dbReference type="STRING" id="387005.A0A183HVC0"/>
    <dbReference type="WBParaSite" id="OFLC_0001143201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001143201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001143201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF23">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001143201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14367" checksum="40960040A8619732" modified="2016-09-07" version="1">MNDRANFEIERARLEEAISVQQEQIVQASRALSFCHNTQEFRGSREEVDAQRALLIATERRRALIFVLDRLIQKHATGGVQHSISDRPKGNLTFWDISVKLMRDFVNGHINYHDGKEIRKLVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW30</accession>
    <name>A0A183HW30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017215">
        <property type="protein sequence ID" value="VDO78492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW30"/>
    <dbReference type="WBParaSite" id="OFLC_0001169201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001169201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001169201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001169201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7875" checksum="F4F0E076A6B485C4" modified="2016-09-07" version="1">MYRNRSNLDYRSHAAEGMRRLIANQTEEDRALVNEQKGKKWLNCEPNDVRPDLSVHACEHVDRVPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWN0</accession>
    <name>A0A183HWN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZnF_CDGSH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11889</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017771">
        <property type="protein sequence ID" value="VDO80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWN0"/>
    <dbReference type="STRING" id="387005.A0A183HWN0"/>
    <dbReference type="WBParaSite" id="OFLC_0001189201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001189201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001189201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF9">
        <property type="entry name" value="IRON-BINDING ZINC FINGER CDGSH TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001189201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="12072" checksum="2D1F9A1A4ECBC466" modified="2016-09-07" version="1">MFFGKDKFQDIWFIFEIFPFWFFQINEFQPLCDGSHLHYYIPTNLRPVRFIPDKDMEVLLSFQVWFCNCKQTKTRPFCDGSHREVCMKLKKASEENENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX44</accession>
    <name>A0A183HX44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018217">
        <property type="protein sequence ID" value="VDO81520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX44"/>
    <dbReference type="WBParaSite" id="OFLC_0001205601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001205601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001205601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001205601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5787" checksum="CD60C82977DE7F4C" modified="2016-09-07" version="1">MEYLSLVPMYPIFDRLKLTFITIILLFRISYLILPSNIPRFVVLLRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXQ8</accession>
    <name>A0A183HXQ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12272</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01018850">
        <property type="protein sequence ID" value="VDO83446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXQ8"/>
    <dbReference type="STRING" id="387005.A0A183HXQ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001227101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001227101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001227101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO83446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001227101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7718" checksum="724610009894A717" modified="2016-09-07" version="1">MKDLLLDLSSRYGVHICGEGGEYETFVVDCPFFQKRIVVDETKIVKHSVNDFAAVAYLSLSKLHLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY45</accession>
    <name>A0A183HY45_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12407</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01039837">
        <property type="protein sequence ID" value="VDP11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY45"/>
    <dbReference type="WBParaSite" id="OFLC_0001240801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001240801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001240801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059024">
        <property type="entry name" value="SYNRG_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25999">
        <property type="entry name" value="SYNRG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="10">
        <location>
            <begin position="865"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001240801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1324" mass="147995" checksum="3240CCE9179295B0" modified="2016-09-07" version="1">MTRKAKSQSEEEKKNFRWCKSHEPEKSQEHWEVLVRGFCDIVECASVRGFYDIIECASICGFYDIVERAAILDSIKLSDEPLCVDSMTVLYTSQITGRSMVHGVRASVSLTSGLVLGVLLSVLLLLPDELIPPDNLDEESSSDHWQVVIKKAAVTTTNGQSQIRKVVRAGFVATELGIREKLVVILLGQSSLMVALNASISRHVPYLHLFADISRIDSDIATLPNLTPHRHLCSSISSSSDHSAFELCIHIATNLSCTSYYQSQTYRWWKVDERLSEGGSGTAIHDTVAWWSSLQNFNRSLSVSPLLSDLDAHALHQHFLNVELNRIDDEIDQLSTEIASLSYDITDGPSQPAGLPPYSKAPDRYQVPKWHFFTSTEIFKNEPNQNVYALSGDDKLDIEEIVAAARKFIEENDEGSDEKFLQLRNGYRLFDPLRGMDYIVDLLYRDSDGSKVNRIHLTRIISNNQLLQQVSYFFFRFIHYPYHAQKEIFFEVPYVKEDTDLTILVPLGSNDDVGAVRRLIVHYASLCQSSVGDNRQTRFVVVVRSVDPFAIRLINDDIIELRMRCKSAQTETMLLILKQDSHPILAAAVLDEAVDHFGQQMIYLLLSPHADIQREFLDRVRINTIRHFQVFFPLPFVEYHPRIVSANEALKSKMRDPNIDNQAEIGETDQKVRAPKTFGDGVDTFMSKFRDATFKRNARPLIVHKDRGHFDSSDFSVFSLYGADFIRTRSRLNNKSVLLDLSSLFLGDQDVHMMRAVEPALRLRYHSRVCDPELVDSDYARCLLSRREGFASKAQLANLLLNRKAKDIGLMAIIIMGVECTDANGVSSKGNGTGEIFYYKLMLFSCSLLGIIMQNGGVLPPSLLQENRVPRFYKEAIAKCGAPSQSQLPNTALVYNLMVTSCLPRAVLGNIWSLVNRTMPGQLTRQEFFSCLALIALIQKGQPLSALSTMSVLPIPHLQACPPFVQHLPGGDIFQKQGGFCKTIQKTPDSSGVAVNPQEMATTSSAVSLLADIDFSKPITNSPNFIQPTAVSITQIPASQSYPSISTADTSHMDSTVTGFQASVALSSNHSFNVTTNLDNQLLSKNIDQSTNNTASSSSQNSALPDEILNVVPSMLRSNSETLHLETIPCSDSNSTNIGADKTAQILEPVQSSDVYATMKLITGASKNGEEEHLYVWRRCIEEAYALLSDAGSLLLCSTAADVAEIVHTERGARYINALDEIHEITLRIRKGRMDKLIKQKELLDKIDQIWARLECFMEKNTDSKSTDQFAETFSTDIPSLCGICLLRVSPSSILEFTGTVYHKQCANLWINRVDSFLPKLKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYI6</accession>
    <name>A0A183HYI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12548</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039865">
        <property type="protein sequence ID" value="VDP11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYI6"/>
    <dbReference type="WBParaSite" id="OFLC_0001254901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001254901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001254901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001254901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8155" checksum="FA607A728612C591" modified="2016-09-07" version="1">MNQGRSPELSNISCMELRNGMLLQTVIFILLLGFLLIIIFRQKRYYNKYFLKCGYVPSFGKYVQRWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYJ4</accession>
    <name>A0A183HYJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bursicon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12556</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039866">
        <property type="protein sequence ID" value="VDP11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYJ4"/>
    <dbReference type="STRING" id="387005.A0A183HYJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001255701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001255701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001255701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="5">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001255701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27504" checksum="DC75D1AF76CFA543" modified="2016-09-07" version="1">MQNSIFIDALMMYPFFIAIENQSVIIINLRIQMLGTLNEETKPKYIQYKVENGSVFDEIAKKAFISLHSEPYIEPPLLTFDQKRLKWLQRYMRKQLKAEKKGKKVLSSPKEALHQVNQEVSLGRLDDSRPAAHCDGQIFKQRIRMDGCLSKVVHNRFCHGTCSSYFIPRLRPRKLKLDAMFQSCSVCRPTEWDTVEVKLDCPRKNPKELKRKVIKVKKCKCIALNGNNLESEEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYT9</accession>
    <name>A0A183HYT9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">OFLC_LOCUS12651</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 29">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01039894">
        <property type="protein sequence ID" value="VDP11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYT9"/>
    <dbReference type="STRING" id="387005.A0A183HYT9"/>
    <dbReference type="WBParaSite" id="OFLC_0001265201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001265201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001265201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045138">
        <property type="term" value="P:nematode male tail tip morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000586">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF602">
        <property type="entry name" value="PROTEIN VER-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="117"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="312"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="650"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="739"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="911"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="848"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="1099"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="918"/>
            <end position="925"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 21">
        <location>
            <position position="950"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="20">
        <location>
            <position position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="VDP11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001265201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1280" mass="147660" checksum="43A9A81B016C1C9F" modified="2016-09-07" version="1">MTHWHFHSFITFRDCGLLCSVIHKRTLAKMRMKQVQCSTAKVFRFGTDSHVCPRSLRATSPTIVLEHHYISPAYSPLSSFHCRTSCRQRLMHLFHPFIAHLFISLCFITSDASPYAPVIVGNIDFQEYKGQQYIEKKTGEALELNCSAMEAVKWILPDNTLYIDFDPDERISRVTESGFDIGFRSLRIEPLKRSDTGEYVCIAEHSGFSSSIYVYVSNDKSGKSVRTGSFLNSGPLIVSKAIRGLNVVLPCRTDKFIESGVELFINHVKQTTRIQFDPRIGFIVDRRLLNDRTEIPVRCEYLGHVSEMVIVPIKNDQEMEDSPVIEISTVWPYLRQKLEMNCTFHTRDGFKYVLTWKCPQCEDGTDHVVSNRYVKIRDGIRKLLFIGDLHEADSGDYECVVTNKDDVHDVRRSVHRLQVSPTRGQLKVIDFSDNVNFEEGDTVRLLHMARAFPSNEYRSEWKKYSKTISSRGELVEKIEKGVRSKLNADIHEDELSIINAAVDDSATYQLVIRVSEDYVYRKNWTLSIRPINIQPRITIHDQFGQPLSSHVLIDSKIIVTCLVKDTIPRKLRLLYIIRDGEWKEPDYSEELSGFTYESAVKWITYAKEHMRIRCEDDETKKMDEKDLVISEVETINAYFIARKPVDLFNEGSSIYEKDHLELICILPLDDEFDVSWVHDNVQLSRPERYITLYSQKFKTTLDNISSDQSGDYHCIAKSKNDRISRTYTLHIKVNRVVAPYIIEANEEYEHLAKYGERTELVCPIEGEPEPLYRWLKNGIEYNGYGSLTKKIDFPRVIIEDKAIYTCVAKNRAGSQQLTDEPAYIRSSKHWWTLGFVTVSVLFLLLLALVFLLKQYRKSKRQKEQLRALYNQLMSESNGEYLAGSIDLKQPLHERVEQLPYDRRYEISKDKLSFKQLLGGGHFGQVYLGELKKPRVSDSLAVSDMLKVAIKAPRDGRNLHHQKALADELKIMIAIGIHSNVLCLIGAVTKQMSSGQLYVIMEYCENDNLKDYLSKNSAGFLNEVEISREPLSSDGYLTPTRNAQHESQIYLAELKPQWATEVDEVRMADKMITTSDLISFGYQVANGMEYLSSKMCIHRDIAARNILVTKNRAIRIADFGLARKDSTVYHIRSSQNVPLPLKWMALESILYHNFTEQSDVWSYGILLWEIFSLGKVPYPQVDNDDLVNYLQEGNRMEQPKFAPDDIYNLMRQCWLSDPSNRPMFSECKVLMKTHLSRASPPRYSEWRDAEETEPDLRAQATRNGFIAVPTQEPQTNSNIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ99</accession>
    <name>A0A183HZ99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12811</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039942">
        <property type="protein sequence ID" value="VDP12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ99"/>
    <dbReference type="WBParaSite" id="OFLC_0001281201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001281201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001281201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF2">
        <property type="entry name" value="CLAUDIN-LIKE IN CAENORHABDITIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001281201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50406" checksum="332644BA53CF4909" modified="2016-09-07" version="1">MSTTEESQSKCGQKTALSLFFLLELIAYVLGCIALISPSWQYVYLENGRTEHHHGLWLDCKRDYSHDYGRSREYYETLYRLNRQQSPFDQFSLPSLLCVYKFDYYIDSEDLYDHNHDENRLQDDANQHLLLGWKIASLAALGFAALTASAALLLSICAFCHRTFICAAAVLVTVAALLSSAGLLVFYIWANYQDNNIIKEEDGIYQNDGQRVSGLMVPLLVGTQELLSTNPLLMNHLVMKISFPNRINSVLNPCSENGYVCPHEAFSMQYFGWAFYVQTAATTMQFLASFAGCAVTSIAFRKSRTKLVKIEVIRAILCSVVDKDNSTLLDRTLPFKRSFSAIYKLDSSDLQKWEKDYTNLIQICNFKRAISVPNFKKYPGKSQHSSQKNKINTVHRKTKSTSNLFTNIDQSNLSTASETFSSTTKIPLSFSFPFPKVTLLLNCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZC3</accession>
    <name>A0A183HZC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hcy-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12835</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039949">
        <property type="protein sequence ID" value="VDP12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZC3"/>
    <dbReference type="STRING" id="387005.A0A183HZC3"/>
    <dbReference type="WBParaSite" id="OFLC_0001283601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001283601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001283601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001283601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="37822" checksum="B244653EBECF301C" modified="2016-09-07" version="1">MDTHFIQEKIQVLDGGFGTELQTAGYNIQNNSLWSAAALFDKPELIFQIHKRFIEAGSDIILTNTYQACISTMMNSRGMTKAAAESSLKKLVSLAEQAVEEHSGQKKVKIAGSVGPYGVFLNNGSEYNGNYVDELEEQVMVDYHMQQTIPLLQAGLKVIAYETVPSCIEAMAILKAADAIDHSYNFWISFSCKDNEQTCHNESFYKCIEKISYHPKILGIGINCTSPNYITPLLQSASTSVSSLPFIVYPNSGEIYESDTKKWRNGKCTFPNIEQLMEWKDLGVKVVGGCCRVGAEKIKELSILSQYGNKSYRGEFEMTHESLPHHATIPPSLCSVAPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZI3</accession>
    <name>A0A183HZI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12895</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039967">
        <property type="protein sequence ID" value="VDP12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZI3"/>
    <dbReference type="STRING" id="387005.A0A183HZI3"/>
    <dbReference type="WBParaSite" id="OFLC_0001289601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001289601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001289601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001289601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22587" checksum="A004130C385F370D" modified="2016-09-07" version="1">MGENLEQSSVEIIIESRLPAWILDKVYQHKEQEPWSVKKLRCFFEKLVLRNEEVMRSQSSNMKERKLFTGKSKSYLQYSPNEISALVTNVPKKSECAFCNKDHWDNECHIYSILKQRIERLKKLNACHNYFESGHIANGCKKRKRTCFFCKGDHNTALCQNKYKDHEQYVGLDKERNNSVNVITPDENTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZL5</accession>
    <name>A0A183HZL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039979">
        <property type="protein sequence ID" value="VDP12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZL5"/>
    <dbReference type="WBParaSite" id="OFLC_0001292801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001292801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001292801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001292801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11484" checksum="FF86CFBE507EC0E7" modified="2016-09-07" version="1">MPLPEEPVSIPDLYYQLRGSSTQYSSTPMPLSYTCCDMVRSFSFSLFKNCADTTSTCISVQFVSLFLAKKSEMCVIDGLRDIINFKFVSFSFRDLSKQKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZW1</accession>
    <name>A0A183HZW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RMI1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13023</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040015">
        <property type="protein sequence ID" value="VDP12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZW1"/>
    <dbReference type="STRING" id="387005.A0A183HZW1"/>
    <dbReference type="WBParaSite" id="OFLC_0001302401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001302401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001302401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032199">
        <property type="entry name" value="RMI1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16099">
        <property type="entry name" value="RMI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ-mediated genome instability protein 1 C-terminal OB-fold" evidence="2">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001302401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24836" checksum="70191C0AC13B0A20" modified="2016-09-07" version="1">KIFRRYIAFSIILVLIFISACQYFQVPFHASQNSFKNSEPQQVEEKSMYNNNTSFKNRATTLLFPDATIQIVPHVNIIERYRALNIVSIREAYHQRKYCLVAHRKRVQPIFCKLHAGLQFIGQSWTAALRIADETCDALDCLVDNNAISDLIGFTPQEAQQAAAISDRARVTYYKGRAQAVLETFKRLDLVLTIEFSSSSDVLPLIVNITNLSTALGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0F6</accession>
    <name>A0A183I0F6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS13218</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01040093">
        <property type="protein sequence ID" value="VDP13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0F6"/>
    <dbReference type="STRING" id="387005.A0A183I0F6"/>
    <dbReference type="WBParaSite" id="OFLC_0001321901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001321901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001321901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000008">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000044">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000013">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="301"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="328"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001321901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="814" mass="91348" checksum="206FCCD3B9F0B799" modified="2016-09-07" version="1">MHSSHNLPGIYTDEYFSASEQEKNVVPVRDPQVVLIQGKKGEDSPSLQRTIPLINDSRIPCSMNASVSMEVQLVDCTNGKQATDVPNGITANATHLNNTKLENAYKEGVAIVDFGAQFGKVIDRRIREQNVFSEILPFNTKAANIVEKGCYKAIILSGGPNSVNSFDAPEFDPAILTCGIPVLGICYGFQLINKAFGGYVSKKSIREDGQLEIDVDTTCPLFKGLATRQKVLLTHSDSVTERAVANDFKIVGRSGNFVAAIADERRKLYGVQFHPEVDLSICGKEILHNFLFDIAGITGGFTIDNREQKCIQEIRSVVMDKKVLVMVSGGVDSTVCAALLHKALGSDRVIAIHIDNGFMRCNESDHVVESLNKLNLKVRRYNAFYAFMNGRISFGSEFSTPLMRTVEPEVKRKIIGDTFMRVKDKIMDELKLDKDIFLAQGTLRPDLIESASHLASSYADVIKTHHNDSALVRELRNLGKVLEPLKDFHKDEVRELGISLGLPEHIVHRHPFPGPGLAIRIICAERPLITDFDLFITTQHHLHLIANLPLCDKDSEEFCTIIQHLSEVDLKAISDHDFEIATTLLPIQSVGVQGLFFYFNPYILKDAEMEIDDRDFHRKEFHHMQSILGDGRSYAYAAALSTNERPIPWELLERLAYIIPRLLHNINRVVYVFGNAIEYPVNDVTRTYLNGFTVGLIRWADRIAYDVLYGLDENGKRDPALEVCLQTIQQMPVVMIPVHFDRDPLERKASTLRSFVLRPFITNDFMTGVAALPGKDIPEQNILEIVRRITEHVPLTSRVMIDLTSKPPGTTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0K9</accession>
    <name>A0A183I0K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13271</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040119">
        <property type="protein sequence ID" value="VDP13322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0K9"/>
    <dbReference type="WBParaSite" id="OFLC_0001327201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001327201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001327201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001327201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41188" checksum="2A2E4149A7CA4DBA" modified="2016-09-07" version="1">MSSDGMTCPAANCYSQIRNALSDSLPIIINYCDNMMCPKKLSQFESTRLTACQHELCTTCLEESLQRQPPACIVENCNRSIIEVEEAYFCDNCGKQMSDSKGNIITNCCKCHLCEQCIENRVKMNLLNKETMICTGGKCLSKKKKIESEEVQVKCKVKDNCKGIALNGFPSNSECNHDICIECLTDMISDCETTGVLPMCPEPTCHQYYTVESVNALRALFPQKAEFFQRFDLNERKTELFCKDDSITFVDLSSEFDFASRRMTVRVVGDGEEEIEGILIYDKQGTIGDFIREVRRVLRILPYEKIYGYFIRNEDETKDENREIAADAESMTKCVSELHLTSTSVVHVDTAGIVQRKSSTNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I130</accession>
    <name>A0A183I130_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDK5 regulatory subunit-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13442</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040201">
        <property type="protein sequence ID" value="VDP13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I130"/>
    <dbReference type="STRING" id="387005.A0A183I130"/>
    <dbReference type="WBParaSite" id="OFLC_0001344301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001344301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001344301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001344301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="57937" checksum="798B0D75857D91C7" modified="2016-09-07" version="1">MMDEKDIPIDIHCSKLLGKLTIHMISLDWLISRRHCNKDWQKNVMVIREKISAAIQDMPEDERIVKLLQGSYINYFHCVQIVDILKDTEKGTKNFLGYYSSQRMNDWMEIQQMYEKKNIHLAEAAQILQRMVQYEIPALKKQISKSDQTITDCMKKERDYAKQIVDSKKQYEKELLKLGIEGVHLKREILSLLADLPSFLNEITRSISSLDEPLQYYEQFQAYLYQNERPNTVLLPLSRLLMEKGAEVTVYEWKNGTKPERIELPSLDAWANEANSAEDEIDFGDDLIIPDDGIDFGDNKFQIEIIGDEKRTVDDRIARGLDALTILENPQTRNLIYFELKELEKFLVVRRKDEILESVSDIYILGMEERPAALRKITVEIIDKWLVHVNKIINRLTDTQKAHLFRIRSSPQYVEKLVETLEQKRSLEERYEKMKALMIEKQSEMRISIQKAHETLNGICETSKVLQKQIEEGISKIYKGRKVNIMGSINAALMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2B2</accession>
    <name>A0A183I2B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13874</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040444">
        <property type="protein sequence ID" value="VDP14868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2B2"/>
    <dbReference type="STRING" id="387005.A0A183I2B2"/>
    <dbReference type="WBParaSite" id="OFLC_0001387501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001387501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001387501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001387501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11952" checksum="5182FBA13A108114" modified="2016-09-07" version="1">MSGTGNKLYYFRFEVIFAVEIFNNEKNRFEEVHDFIDYALTNDGVCLLESRMFYMNCESSLQDFLDLVKTKGKFDVYTRWSTPKSEIIQRRVIQLTRAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2U2</accession>
    <name>A0A183I2U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14054</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040565">
        <property type="protein sequence ID" value="VDP15376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2U2"/>
    <dbReference type="STRING" id="387005.A0A183I2U2"/>
    <dbReference type="WBParaSite" id="OFLC_0001406201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001406201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001406201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CX" evidence="2">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001406201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31991" checksum="E4A344A91EEFF192" modified="2016-09-07" version="1">MYKAIIYLLLLTQGISNARKGGFFRGSSGARTNARSGSHSAGGFHSQTNYRPQQGGYHPQQGAYHPQQGGYHPQPGGYRQPGTYHPGGGYNKQQPGNPNQDKLKLAFKRKTFLNFEINQEKPLSPNTGTFKKALLGGALGAAAGIATFELGKATFLTAILRSSSEPLKAPNGQNYYFDERNHQSKNGYFMCSMPIHDVVKTLQENSTSTPTTDESRNSTAMTPEQFFKTVQFQDGSRPKSLTWNCMSGTEVCCGTECCPAPKRDGGNSIHHKRPLLIIFVRCVDILKFEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3A9</accession>
    <name>A0A183I3A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14221</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040685">
        <property type="protein sequence ID" value="VDP16042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3A9"/>
    <dbReference type="WBParaSite" id="OFLC_0001422901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001422901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001422901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001422901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9179" checksum="16FEE8FC29EF1D2F" modified="2016-09-07" version="1">MQLLSRSDFVISRQMYNKQVICRVLRIVNSRKSLDFAIVQEKYAPVVELYIVQIWREDNKKIDGMGRTLSGKTTRTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3C4</accession>
    <name>A0A183I3C4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14236</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040696">
        <property type="protein sequence ID" value="VDP16126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3C4"/>
    <dbReference type="STRING" id="387005.A0A183I3C4"/>
    <dbReference type="WBParaSite" id="OFLC_0001424401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001424401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001424401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="499"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP16126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001424401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="752" mass="86614" checksum="1CDAA54BA22DAE1C" modified="2016-09-07" version="1">MLRKRAGTPSRRGGKRTDNKENVEVVCRLCPYKGDDPCLIPIDDEHVRFVQPASMQSRNGIQVETVYKFSYVFDENDSQRVVFECTALDLIENLIRGKNSLLFTYGVTGSGKTYTMTGNTEEESIGILPRTLDVIFNSLINRIDKCVFKPDGRNGFTVRDELESAIARRRLELERSDNGMELANRYVERRRVSGANPDLACAVFVSYIEIYNEVCYDLLEEPLLKADGTKTLSGKDIKLGANNMFYVGNITEVEVDSSDEALEQFYRGQERRRVGDTLLNKQSSRSHSIFNIRVVMAPCLPDTCYPDSDPTKIHVSQLSLVDLAGSERTKRTGNEGARLIESGKINQGLSVLRQCFEKLRDNQLRDKAVTISYRDSKITHLFKNTFEGTGKVRMIICLNPKPEDFNENQGVLNFAQLSKDIAVSEGNEVLPPSQSGFPISRRDFLKWLNKLGSIHIPDKEVLSFPSPPPFTISDSEDAESIARLRDYYQHIAQERGSLQEIFERKAAEMEQQLQRALCTVDLQEVRIEELEAERDETERLLSTLTYKLKQLRRENFVLRQRLEHCELEENDKLNQEEEHRRRERLYQEQLRKKEKTLHQVREICERPLISSTKRFKSIENIHNTTTADDVDLVNNDKTTQNEELPTPHRVALARQKWEARTANQNASVKTRTGYYNTRFHRRSKSANCRVIDHQPRNRIPEGTILQPRMPKFCRTTNKLNAEDLKKCSDYVLTHQEVDQKGCLTTHVVKVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3L8</accession>
    <name>A0A183I3L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040773">
        <property type="protein sequence ID" value="VDP16554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3L8"/>
    <dbReference type="STRING" id="387005.A0A183I3L8"/>
    <dbReference type="WBParaSite" id="OFLC_0001433801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001433801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001433801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001433801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11403" checksum="0EC8DEAC0E45F4F7" modified="2016-09-07" version="1">MPKFPDVRRTYGAFGKDQDMSQLFKTGTYLHWKSPHNMVLCCIKYGLLTVEQKEQQLNVIITNPMTQERDSDDKEVLLLYNEVKVSKPNMQKQPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3U4</accession>
    <name>A0A183I3U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14406</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040830">
        <property type="protein sequence ID" value="VDP16909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3U4"/>
    <dbReference type="STRING" id="387005.A0A183I3U4"/>
    <dbReference type="WBParaSite" id="OFLC_0001441401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001441401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001441401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP16909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001441401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29168" checksum="EA16BB2D0BEFCAC3" modified="2016-09-07" version="1">MLMRIILRRIAYTYLVYNHEFMMDFRSEVRTFARPVCSKSYETNSTLIVTAYSDLNAPRFLSSASLISTAMFKTLRRLHGYNLENRGLNDLSEKFQNFVTRARFFNIGRLRRTWSHSAIEFLKYRRLLPMLVSDKQRDSSYQRSKNDDRKILVTNISCRVTANQLISFFSKFGPIASCYIPSEERQYSLYATLPKKSRSNLTAFIIFKSMEGAERAKNATADDLRFYDQVMLISQIFTVMFLKSQQLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3V0</accession>
    <name>A0A183I3V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14412</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040835">
        <property type="protein sequence ID" value="VDP16943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3V0"/>
    <dbReference type="WBParaSite" id="OFLC_0001442001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001442001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001442001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001442001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8368" checksum="1861CF8361E2C029" modified="2016-09-07" version="1">MILHISTSDIRSTFCTSNCRLASQLLRVVLLVRVVTYATVSREPNQTITSATAQSSTTQPIDAPPNCSNEQHAPPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3V8</accession>
    <name>A0A183I3V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14420</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040840">
        <property type="protein sequence ID" value="VDP16975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3V8"/>
    <dbReference type="STRING" id="387005.A0A183I3V8"/>
    <dbReference type="WBParaSite" id="OFLC_0001442801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001442801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001442801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000807">
        <property type="entry name" value="Low-density lipoprotein receptor domain class A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like calcium-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like calcium-binding" evidence="3">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP16975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001442801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47605" checksum="C9FF8FB717312EB9" modified="2016-09-07" version="1">MHETKRKGITCETNNENGHCKHLCTDVTNGYYCHCRDGFQPNPDDPYDCIDIDECMGNNTCTQSCLNTKGSYLCRCLEDYENNVVVGAMTGKDCRAKGDPPLIMIAADGEVVQLSLAHAGETNRHAVDTLDQNDIIAVDFDPRRELMFWIDRQQRKIYRSALPKGNQSHAGQELNIDFKNLKSSPSALSIDYLTGNIYLAVIADEEAAGFIARKKRHTEQSENENGRGTIYLALSDGRYLRTVIKGRLQIPTAVITLPQIGRICFADAGFEAKIECADMDGKHRDVCTKRTTVIMDNRMPWAIDVFENNLYWASKESRDLYVQDKFGRGRISVLASNIPNAHNIRVYQRFARDTSRAVSACSQAVCSHLCAELPLNTYTCLCPDESPQLDLKIVEISHVEKNLCPFSWGRHGKYEDFENYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I536</accession>
    <name>A0A183I536_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14848</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01041276">
        <property type="protein sequence ID" value="VDP19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I536"/>
    <dbReference type="STRING" id="387005.A0A183I536"/>
    <dbReference type="WBParaSite" id="OFLC_0001485901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001485901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001485901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="67"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001485901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34231" checksum="62AF3BECB3AF09ED" modified="2016-09-07" version="1">MIRTKLLSRYSTLAVRALVTASAAERCFTSGRCFHSHCAADLPTASVHHQNVKDVHASCCGFPKHLKNGPSTVLDQGVFGDDACFIARFENTYVVGVADGVGGWRNYGIDPSEFSSRLMKVCRKIVMKGQFKPNRPDKLLARAYEALSRPPRPTGSSTACVLIVHQDTLYSANLGDSGYLVIRNGEIVYRSHEQTHYFNAPYQLSLPPADEGNNGFLGDSPEKAESASLDLMSGDIIVLATDGLWDNVTEDEIVKQLSGLKPGDVQKACNSLALTARRLAFDTQHLSPFAVKASQHGIDAPGGKPDDITLILLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5S3</accession>
    <name>A0A183I5S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dual-specificity kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15085</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041588">
        <property type="protein sequence ID" value="VDP20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5S3"/>
    <dbReference type="STRING" id="387005.A0A183I5S3"/>
    <dbReference type="WBParaSite" id="OFLC_0001509601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001509601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001509601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001509601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15355" checksum="3A920A4ABBD12725" modified="2016-09-07" version="1">MNINVFCLQGSTGSRASGLPLQSSSSSSSCSNATALQGGIKRTTNRTPQSSGAQLRQPPNLDPTKNKRFSKSSEEDSAYAGFGSSSSPISSAESSSMSINSTSSRNSSGSGTTNPRVRTLTALTFHQTTANHRFIGGTIQPPSSPHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I643</accession>
    <name>A0A183I643_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIB/HERC2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15205</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041760">
        <property type="protein sequence ID" value="VDP20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I643"/>
    <dbReference type="STRING" id="387005.A0A183I643"/>
    <dbReference type="WBParaSite" id="OFLC_0001521601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001521601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001521601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001521601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18742" checksum="A0C6B3B329DB1E36" modified="2016-09-07" version="1">MAKYGISIDIRQGDDVPHGAILSGTGYVDWHETVASRATSDYARIPFGTLALVDGTYLIEPVRDDQMPRKPSSSKAHIVYKSRSHSFHKYDFSSSSTIIPSTPSLIITSTATSDNSSYSISNNDNNSTSDFQIQNHTAYRVSNDNADYDNNTAQYVTIFDPNINITGFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6I1</accession>
    <name>A0A183I6I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15343</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041990">
        <property type="protein sequence ID" value="VDP21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6I1"/>
    <dbReference type="STRING" id="387005.A0A183I6I1"/>
    <dbReference type="WBParaSite" id="OFLC_0001535401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001535401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001535401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001535401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29466" checksum="9ACE1F11D88EC37D" modified="2016-09-07" version="1">MLDYMRQIVNAAPYFFPKASQPGSSSFPLSSLQPGSPADECSRGNSSGPTDLANLSKNDYLSKNEKLETESIENCYGNPSKEKDNFSFGFPANPRKRTRTTTVTGCVEIHGGSQTESVGFVRFGSLLSLDPALLNRGNDFSMIRKKSSCITDGVRRARRHEEYTSITDAIDLDESSQPDKSLFCESDLSETHNSHDMENDDLVEDDDNMELPYSGTITPTTTLRRAKESFLRHQNDIFKEYEEVRIFFFIKMPLENLSSDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I763</accession>
    <name>A0A183I763_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15575</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042387">
        <property type="protein sequence ID" value="VDP22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I763"/>
    <dbReference type="STRING" id="387005.A0A183I763"/>
    <dbReference type="WBParaSite" id="OFLC_0001558801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001558801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001558801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004714">
        <property type="entry name" value="DEAD/DEAH box helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001558801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24956" checksum="0498324EEAB08C76" modified="2016-09-07" version="1">MITVERLCVAGRLYPIELKYMPIKEHDQYESEKKKTKIDAGPYLNILQMIDAKVNSNERGDVLIFLNGVSEISTVAEALKVHAEISKKWIILTLHSTLSTEEQDKVFDIAPLGIRKCILSTNIAETSVTIDQIRFVIDSGKVNLVKFDSKTGMHSLKEYWTSQASAEQRKGRAGRTGPGICYRLYSQQHFDKMDPFTVSEIKRVSLESLAMQIVNMNLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7D4</accession>
    <name>A0A183I7D4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15645</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042534">
        <property type="protein sequence ID" value="VDP23031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7D4"/>
    <dbReference type="WBParaSite" id="OFLC_0001565901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001565901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001565901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001565901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7556" checksum="742D41667F71C62D" modified="2016-09-07" version="1">MSNGRDDDADDDDDDDADDDDDDDDDDNNDDKKKNGRDDDADDDDDDDDDDDDDDDDDDDDDNNDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7D8</accession>
    <name>A0A183I7D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042541">
        <property type="protein sequence ID" value="VDP23050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7D8"/>
    <dbReference type="STRING" id="387005.A0A183I7D8"/>
    <dbReference type="WBParaSite" id="OFLC_0001566301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001566301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001566301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001566301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12925" checksum="B723DD61301640FB" modified="2016-09-07" version="1">MFEQLGVVETDPIINGLSKKLCSEISNFQNKASAKGEGDISLAKARSEIRKMNKRFIARTVEVLSRTLITDMENDDIPSWWIGKCAIAVQECFVDTVGDIAEYSSSLCRQLSVNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TZL4</accession>
    <name>A0A3P7TZL4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000338">
        <property type="protein sequence ID" value="VDO27301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002429">
        <property type="entry name" value="KETtiN (Drosophila actin-binding) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000119">
        <property type="entry name" value="Sallimus, isoform P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000962">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="189"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="330"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="485"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="617"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="880"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="1475" mass="166460" checksum="D2799FB49EBBA5B3" modified="2019-02-13" version="1">MQFEEHRPFLPRPTYQLPSPAQLNSQLQYKQQYEQHHPQTHFDYIEQNQYYQNMPLVERIAPQRRFTGGQDYAVQNGQSRQIGQSEKPPQFSRIPSSETVKAGESVTFVAKTTGQPVPNLSWYRSDGSHIATNGRYKVEIFNDGSTKLTINKCTTEDNDTYLCVAENKGGAVQIRCSLNVLEQKLSGLPQFVSKFQSVTIYEGDSLTLYCKAVGAKIRISWSKDGTPLKSGGSFRIDDKGNGETTLQILNAKMADGGWYQCDATNDSGTSSLKGRIVVQTRQKLDTANQDQITLRKIDRRMARYFLRNFRYGGKMEEDIDEKRISSKQPPKFLDTIKNLNLIEGQAALLSCKYSPPDDPNLKIAWLLNGKAVITSSRLSTVTENGYAALEINPVKVFDKGEYTIVAVNTLGEARQSATVNVIGQLIYVPSYKKIYLLRRTEEICLKSVFPVSVSGHRSALADASNVTLYDRSQIDKTAARIAEMPNFHTELRSMEVFDGQHVHLEAKFSPADDPNIKIMWFFNRKPLNQSDNVRMSNQFGLVTLDILNITPAEAGTYTCQLANEVGIMESTATVLVQPCIKDFEQRNIVDVEDAREFRNEVDASDHAPVFLTNLSNCHCNQELGSSYFEARIAPVNDPTLKVIWLKDGQLLPNANRIQTFNNFGCVSLTLNPTYPEDEGIYTCVLKNLRGTAQSAAQLTTVHTTSLQLESKHEHSLAQIGYLEGQQVHIGPPSVERPEEFNSMEQPRFARQLESHIEVNENEPVHFEARIQPANDVKMVVEWYHNGAPLPAAHRLRPMFDFGYVALDILYAFPEDSGIYTLIARNELGEVQSNLELIVNSEKSLYLDAHHPEGLDRIQELEQSRIRPLEYPADRECDHEPRFIGDLHDLELNENENIHFALKLEPMNDPTMKVDWYVNGRPLLASSRVRTLYEFGFLTADIRGVIPEDSGIYTVNATNALGEATKECTVTIKPHATVLSETQHQESLGKIHQIENLNKYGRQEVEDKGPQRPPCFVKPLPGDIGEVEEGEPLHLECQITPVNDSTLHICWLKDGKPIPTGHRFRTFHDFGFVSLDILDVYAEDSGTYTCVAKNALGQADSSISFTCRDKERILGQTQHPSSVARIQEIEAPKPAPQEISDAIKEAPKFIKHIGTGEMIYVTEGDNVYLGAQITPVDDNSLTYEWFLNDRPLMKAHRFVLSHDFGFIALNILYMYPEDSGTYTLVVKNAAGEARSVADIDCKAKGSMITESFHPNSVQRIRELEMPLQLPDERPEAPRMAPQIVRTLPPQLDNVHESQTLHLEAQILPVDDNQLKVEWLHNGHPLKAGSRYRLMNDFGFVSLDIDYIIAEDAGSYTLLVTNPEGDFSFTLINISASRAETSTQFDVERLKNIYMDTEHPESLRRIQEIEAVQPAKPSEEELIPEMPSFTQPLNGPKEVLREGQSVHMDCMVQPINDPNLKVDYYFLIRKKLRSQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U4L4</accession>
    <name>A0A3P7U4L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000653">
        <property type="protein sequence ID" value="VDO29416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1P5"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="331" mass="37358" checksum="0772847DF0787B04" modified="2026-01-28" version="1">MGSITDYYPGAISNLLVKKESNIANDGEGRKRKKETESRNNESVALFKKRINKSQYFGLPTGEKKLQPKSVGLNGTEDLTSGSSFQESSSCEMKMKKEVTMEENIRTIFVGNAPLSSTRKGIKKLFSQFGVVESVRLHCIVSNEKITKKRNIPSDVRSLTFYVKFKDAKSTEAALALNGEKYDGNLLRVDSCCIKRKYSSRTTVFVGNLPYDVSENELIAHFETSGNVSFARIVRDSKTGSGKGFAFVAFKESEAVQFALQLDGSIFKKRRLRVKRVQKKNKIRSETYQHSRRTVSTQLNRHMPFDRSIKSTSKKKVRKGGKRKVKNSIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UGC0</accession>
    <name>A0A3P7UGC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000887">
        <property type="protein sequence ID" value="VDO30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H2P8"/>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09942">
        <property type="entry name" value="SH2_nSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF10">
        <property type="entry name" value="PI3K21B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="421" mass="48941" checksum="DFCFB156401A862B" modified="2026-01-28" version="1">MEKKEEDCAHGLQQQEWYWANASKEEIASAICDCPSGTFCVRDASTKGNYTLTLRYGERNRLIRIIVAGEHCGFTEDMLKFESVVSLIDYYRRNSLLEYNRQLSTELLYPLRKPNFEQTSWVIDGARSVEHLLCQLRGLHAAHLRVIRHDDQITAELDSLKEELQRKRHAHAAFTAAYALFLKQMELLESNKQMLFDESEIAQLNKNKESQQRRLESIRYQQQQMVEQIEAIEKNIKENEALHCSLTPKLTKLHKELDTCQFRLCQLNVSQATMDKVLQEVSFLADLEQEPLARILLQLTLRWQPDRYLSLDCTKDSAFKIIRSLMDCNPDNSNGIFLIRPSQSQAGHYALTISNENHIFNCLIEYRDLKHPESSGYAFLNTKLFFSSLVDFVRYYSHCSMKEHNAQLDTKLKIPAFKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UWY7</accession>
    <name>A0A3P7UWY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000373">
        <property type="protein sequence ID" value="VDO27564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0A7"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="232" mass="26036" checksum="105CF5C462CE89D8" modified="2026-01-28" version="1">MITNQIGTVVLGIALLLSLRDIYGHSKDEYNDDEMFEKEFGDEDIGKKLEDTDHIRVRQGSHFTAPPHTTKKLPSMKFLFCVSCGYRQAFDEFSRYIHEKYPSMKIDGANYSPKAWKNILAQIIGLGKIVFIVLIVMGQDPFASIGQPTPRIFAWALSNKVSSCMMLFLLSNTIESSLMSTGAFEIYLGDEQIWSKLESGRVPSPSELVQIIDQQMELQGAKISGTFAFDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W4D8</accession>
    <name>A0A3P7W4D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002753">
        <property type="protein sequence ID" value="VDO38093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H8S1"/>
    <dbReference type="OrthoDB" id="5826678at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="164" mass="18805" checksum="56AF1E0C1A0F6A94" modified="2026-01-28" version="1">MHGLLSLTVRPIHIQRISTLKAIRYFSKTVQPLRCKVEVGKEAKSLVEKAARKLDPFSAVQNEPTANFSHHLGFHGFELYPIQGQVIAWAIVLVLIAYYASAKIEVVIDRSYKNAPFTWATMKDRDREYVAFGFEPTPAISRLDLMETLQEEMIEEARRRGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W7S1</accession>
    <name>A0A3P7W7S1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NHL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004502">
        <property type="protein sequence ID" value="VDO42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W7S1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29326" checksum="A9B7CDAD973AB213" modified="2019-02-13" version="1">MLNFYKFQNEIVVADKDNHRVQVFSERGDFLLKFGERGRTPGLFNYPWGVAVNSFNQIAVSDTRNHRVQMFSPQGHFIRKFGFDNSLYNYKNLDSPRGVCYLQDGQLIITDFNNHRLVVMSSRGTVDMKMYGSEGDSEGSFCRPQGITTDNEGHILICDSRNNRIQVLSLDGMQWVASFGGAVPVLPSIAGVNNTVSEAAVENVITPLGNMSATHTTVKTSSPPQLSTSTNAPKHSALDRPTDLCVSPDGLIYVVDFGSSCIRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WPV6</accession>
    <name>A0A3P7WPV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007264">
        <property type="protein sequence ID" value="VDO49554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6347891at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="81" mass="9527" checksum="59254E079806BDC3" modified="2026-01-28" version="1">MLKHLASFGIGVYVGIYLDQNRQIQAVSSPKELFSRFLDEADHFLTGVREESTSNRDQVRKAEDDFFKDVEDWFIPKKRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XKF5</accession>
    <name>A0A3P7XKF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000199">
        <property type="protein sequence ID" value="VDO26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZB3"/>
    <dbReference type="OrthoDB" id="6412411at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="328" mass="38112" checksum="4202059E7AB7B0B0" modified="2026-01-28" version="1">MSSRYYIVRPEEVISWDERLSKLHGLTYNQLLQLISPNEMAIEFAARYNLISNSMVCKRCGQMMLLWSRNGLDGLQWRCMHVVTKQERRNGRKRNYCSSLSIRHGSIFHGHHLSIADVIEFMYLWAQNYKLHEIRLHTHFSSEMSVAWADYMRQIASGFIEASQTPIGGPGVVVEIGRLILYKTRIGEQHPYLIGMVERETENCIIIAIKDYTTERLKEKVLEWILPDTILISDEGTYIDGLNQLDYPIFITESYMERFESINGQKLSVNNVLLQNICNEAKAKFLAMNGTCKAHFEGYIREFLFRRTFQNGDEFAGIILWAPLLHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XTE9</accession>
    <name>A0A3P7XTE9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017130">
        <property type="protein sequence ID" value="VDO78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XTE9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="125" mass="14806" checksum="31F9F1114DDC1F0C" modified="2019-02-13" version="1">MIAVDFARFFFEKLLHFIQVVIATPGRLLDVLENRYLSLDQCTYVILDEADRMLDMGFEPEVQKVLEYIPVTNLKPDTEDAEKEESIMENFYSKKKYRQVNIFSEENFFPTLNDWCLLKDSFIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YUK2</accession>
    <name>A0A3P7YUK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005353">
        <property type="protein sequence ID" value="VDO44798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HEK7"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="146" mass="16972" checksum="30404DF60E58A216" modified="2026-01-28" version="1">MNSNITSERKMEIMLLEMSNFVMRLDPRMRVRFSDELQKVLVQSLLDGTVFAIVESLSDLQRMNETQLYNGRQQRLMELQCIPDLDEQMKQIDINIVTELDKIVAQQQDTLCRAGVPAFRITNNPQEIELQMAIISFILTVRARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z0B0</accession>
    <name>A0A3P7Z0B0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-tyrosine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005297">
        <property type="protein sequence ID" value="VDO44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z0B0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17309" checksum="06C32B6EAB065FDC" modified="2019-02-13" version="1">MQKEYGVLKVTCNRVIQEEKTLTISNLIVTNGSKKLSVEHIAWNDWPDRGVPNNFLAPFRLLQRIKNQTHVVIHCSAGIGRTGTVVGLDVADTMFNDGMKVTMRDVVRELRLQRHGSVQTDIQYLIKRDEIASFLRDFEILAHARGSLPTPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A1G4</accession>
    <name>A0A3P8A1G4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009271">
        <property type="protein sequence ID" value="VDO55032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8A1G4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11819" checksum="F04D0B9569558F15" modified="2019-02-13" version="1">MRISFQLRICSAHFEGGEKKEGDIPVPDPQVRVLLQLDAPISIELPPKETKSSDRRRALQQPRSSARSTPCSNSSAASTSVKRGRSLVVTADYLASWKNRSVIDGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AKF8</accession>
    <name>A0A3P8AKF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040452">
        <property type="protein sequence ID" value="VDP14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AKF8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="639" mass="72425" checksum="ABD976D32160A427" modified="2019-02-13" version="1">MFEVTGVEATIRSSDSYSTNKSKSLEGQKPCEWISPKKSMVQFFAEKPESPEILGECCDSDEEQDESVVELEEQLQTKQHSDSEGFAWQLLRLALTHQQLYRMKSFLQLAGLEYSELPALSPRANAVFKLIENWAKRLEEHLYAMPGGCPSDLLPDLSIRKSDSNAELPLRKYNVLKETNNTPFEYANPSMLPVKRIWLYLTRQDHILPLFIKHIFGFGDRQKHILLILDFNVQEETILREGAVELENKDTINVFKIVQREHEPIAAFCCSEVRPGWLVVSNTRELQEIDITALLDDTENLKLSSWLFNRTELDVALDGTKRDVFKDNDDYQLITENRQQTTAINTMTPFIVDRSRKALIKMYKRQVNGIRRLDSHPTMPYYVSGSSDGSIRLWEWGVGQPFLTPRIAGQYAKVTKVVFSYNGSKFASVDNDGILCLWQTTQGLPIKKPFFNQKCHSKSAADVRFLGSTSSVLVTAGLSLSDENISLWDTLMPQSKALIHSWTTHPEGATSVMYLSSYQAIVSGGRHGELCIWDVRQRRLRTTVKCFENSSVKCLVGDPFQQIIVAGSSDGDIKIWNTDLVPQLVTSLDSEHIARGGFSLRQVASVVQGVQQLYVDPEIRLFSCGADCSLKIRSLRNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CDU8</accession>
    <name>A0A3P8CDU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040775">
        <property type="protein sequence ID" value="VDP16585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I3M1"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="268" mass="29521" checksum="A1A6966B83E04EB0" modified="2026-01-28" version="1">MFEAKLGSASTLKRIVDAIKDLVTDAPFDCSETAMCLQAMDSSHVALVSLKMDVGMFESYRCDRTINLGLSLAGMARALKCANNEDTCLIRYEENDDSVLFLFEDTKRDKSQEVIVKMMDIDSEHLGIPEQDYSAVVSMPAAEFQKTCRDLAMFSDSLMITVTKAGIVFTGKGDTGSSTVTYAPSKNADEEEQAVSVDVKEPVTVNFSIKYMNHFTKATGLSDRASFLSVRLSLCNSVPVVVEYGLSENGHLRFYLAPKIDDEDADMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F5P5</accession>
    <name>A0A3P8F5P5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040489">
        <property type="protein sequence ID" value="VDP15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2I4"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="349" mass="38108" checksum="813BA2F78532A628" modified="2026-01-28" version="1">MDIDGISSYRSQFGAAKFSRVRWLDLGGKQMKFLTSTYDSRNKQIAAWSLIEDVELKDDIFSCECKLIVDTDVNDLLLYDGTRFAAAMNDGSVRLLEYDEGVIKPMRKYTVMHDGCSCNALCYNNDKIICGGDGGTFVCIDLEGNSKEVISLSMASIRSLASVARDIFVSAHLDGQICLWDLREETESFSRPVFSCRVTDCFQGTTSLAAHPAEPNLVGFGTEDGGIGFLDTRRSSYLLNAVAVSFPVGTVWEVAFHPVYPSNFYCATGKGHLLHLSTKGCGLSNSISNFNGQSRANAWLSPSVRSGNTNVTALIDCLSSVSTFSVSTNGIIACSDNQMITYIDKKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FAW0</accession>
    <name>A0A3P8FAW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040772">
        <property type="protein sequence ID" value="VDP16536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I3L6"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF26">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="283" mass="33312" checksum="AB1F9C21056764D8" modified="2026-01-28" version="1">MVTQEQILAAPKINVRHFVEIITSPTFPEQESKEWVVQHQNLAIQACFAYFFVIFGIKYVIMRNREPFELKLPLNIWNAFLALFSIMGTVMLFPEFIGTIQDKGLQASYCKVYGFTKGSNGFWVWLFIVSKLFELTDTVFLVLRKKPLMFLHWYHHILTLIYAFYSYPHSPGFNRWGIFMNFFVHAFMYSYYFLCSMKMRVPRAIAMFVTCLQILQFVLSVLILAHLGILIYVRKVNCDFDDSIFKLALFMDVSYLILFINFFCKAYVLGGGKSKYRSDKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY70</accession>
    <name>A0A183GY70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000045">
        <property type="protein sequence ID" value="VDO24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY70"/>
    <dbReference type="WBParaSite" id="OFLC_0000017901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000017901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000017901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000017901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34067" checksum="57B3556F23641C9C" modified="2016-09-07" version="1">MISDDTNLFQNLKLSKQIEETNNDGDSTLNEISYGPGVVQKLCARFLQLSKEHNAVSLIRSPRFKRRKSSAENNYTVISEIRRCSTRTLTTSNLKNKVFLNTAKRSLNFGDEQKNELNLVPAVKDFKQHSQQTVDTAELNDTYLYHAILIPGNTRANRKAKKIESIREKFEKISAISSILPHEKFNKVRFRRGCSSSGVNNESLNRKSELVETQGEIRKVRHDGCFEIEQDKGNMQLPVPTNTVKVLVKSEPSDDGNLTVTDLSAVSSVSSLSNFEVNEVPPQIKERTEILLVKCQANGSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ22</accession>
    <name>A0A183GZ22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS482</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000160">
        <property type="protein sequence ID" value="VDO25949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ22"/>
    <dbReference type="STRING" id="387005.A0A183GZ22"/>
    <dbReference type="WBParaSite" id="OFLC_0000048101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000048101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000048101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="270"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000048101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46559" checksum="3E0DC1302A2F6A64" modified="2016-09-07" version="1">MNFEKQSTVEQKGVRNDACPAISGNPSYRASCKIFGGCVQIAKQMERTQRQILDSVLGVIVWKELTEVDFFSDYIWDGLSVMITNLEELIHWLTTYPAGLKLNSHLNAILSQFFVYHIYLWQTYLSVASVYIGFGFISLSCFFGLSVFFAALSDLLRLLTVHIYCFHIYAFKLATLSVMSIKSLWRLFRGRKYNPLRQRVDSVKLDMRQLFIATLFFIILLFLLPTILVYFFVFSSAAICVFTFMFIAVPLPTISIDRVVSILIGEKALLSRSLAILDIRPEEQFVKGHIIGAEHYPRILLSRENYETESMKRVGTQGTLVVCGQIYGASQVVSTLCDRGYNAVLLRGGIASETLCLKNSEYSDLDNWRHKYPEGLLTTANGKPVKLELSKLIAQLAVNQKPAFERSKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H019</accession>
    <name>A0A183H019_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotyrosine-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS830</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000330">
        <property type="protein sequence ID" value="VDO27249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H019"/>
    <dbReference type="STRING" id="387005.A0A183H019"/>
    <dbReference type="WBParaSite" id="OFLC_0000082801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000082801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000082801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000289">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000082801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46878" checksum="C4C1E736B11F2D3D" modified="2016-09-07" version="1">MPLSEFLNGYPTSSRHPSASGSGSYYYSRGGGSLSSNAPSPAVLPYNSIPSQQYNGVIENSTMSVHGSSRHPSAVESDTPSYWVEHLATFAVGREFGLQYPEDGVRKLKQLENSSAIWAQPMVLRLRPSVVSVEDENGDLVEQFPMELVTNPTAHLSTNPRDVYNNILLFIVKEDKKRGRSLNPTEMHIFQCNRVSANDVVDDIKAFLSGHYKKVRTGRRDTGFMIGYQPPFVMGLPSRGYHDDTSASSDSSESFERDVNTLNRCFDDIERFVARIQSAAIAQRELEAQTHRQRAHRKQNSRTPIDPQSGILQMRAQLPAEFEFVDILQKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLTIILDACRWGLGRNVAPQVVSPLLSRETRELLQNCLTSRESDVWMAMGEAWRIAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H047</accession>
    <name>A0A183H047_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000344">
        <property type="protein sequence ID" value="VDO27337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H047"/>
    <dbReference type="WBParaSite" id="OFLC_0000085601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000085601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000085601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000085601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12300" checksum="EFC239319721F0BF" modified="2016-09-07" version="1">MESVCRRALRAIMRIHPNAFPNFLSTITRSGDIVITRWEGPRWYACAGLDWIVPQNWAFDLGWSKSGSGFCSNTIIKTNPKSEKSDKMADNIAFPFFLIKVIFWIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0G8</accession>
    <name>A0A183H0G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS978</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000405">
        <property type="protein sequence ID" value="VDO27770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0G8"/>
    <dbReference type="STRING" id="387005.A0A183H0G8"/>
    <dbReference type="WBParaSite" id="OFLC_0000097701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000097701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000097701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000097701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29902" checksum="6D28DD579F6CD144" modified="2016-09-07" version="1">MYYRFGVFIWLFKDNNLQGISFLDMHFYIHQLIGVRNLALACDMYRSVALLRYQEEYKALSLASRDMRSDVQPPMAAQFIIDNKQMGFVMSDEAANIAIFNYLPETLESLGGEKLTLRAEINIGTVVNSFIRVKGHISSGFVENELFSLERQSVLFASLDGSFGYLRPLTEKVFRRLHMLQQLMSSMVLQPAGLNAKGARAARPHRPNHYLNTRNLVDGDVVMQYLHLSLSEKNDLARKLGTSRYHIIDDLIEICRVTAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1L4</accession>
    <name>A0A183H1L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1374</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000632">
        <property type="protein sequence ID" value="VDO29298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1L4"/>
    <dbReference type="WBParaSite" id="OFLC_0000137301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000137301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000137301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000137301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9391" checksum="BBC225D7E7A7EB0D" modified="2016-09-07" version="1">MYNLVDVVKIIFITGCTFGHAIFLYLLNSIFPRNPNDSHPQSMLPNGIGFNTQHKYRKPVSYGQVLFPRLIRDQSREHVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H219</accession>
    <name>A0A183H219_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000734">
        <property type="protein sequence ID" value="VDO29877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H219"/>
    <dbReference type="STRING" id="387005.A0A183H219"/>
    <dbReference type="WBParaSite" id="OFLC_0000152801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000152801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000152801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000152801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23168" checksum="3BF96C9CE11D11E1" modified="2016-09-07" version="1">MNRSTVSQHSSQHASPNSAFFKPLTASAQHVSYTGTAFVQMVSGASCTSIEERLKMKEVTRPVPTIPKAALPVLGRPVYDAFKDEAEKKVVVSEPSRKVWPSVLFHGSINTKEVMSFPTDTLKKKIVECDSYSNLPVKKDISPLPYNPGKDLLKNYSKEFDERLKSTRILLTTTNHMTEDRPLINPCKAWKSFKEARLMFKTYPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2N8</accession>
    <name>A0A183H2N8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1748</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000882">
        <property type="protein sequence ID" value="VDO30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2N8"/>
    <dbReference type="WBParaSite" id="OFLC_0000174701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000174701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000174701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000174701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34591" checksum="E9595C4600762E06" modified="2016-09-07" version="1">MLEKRLEEERSGKRIGTEKDNIEILQPKLMRDKFVGSLTFIHIYSGKLKPFGVNLYEAVWCKSVLGGLEGGGGGKKEYNILGQKNFGTKESTTSRHEIFVEHKRSISSLEATKESQEKDVKERPNVEISSERNRRKKKLTESENDGHETKIVEKNQFKPPRSKNLKEVELKPLEVVMLENNVSTEYEKAKTMQCEMSDIYSDRIISETARQESRRQDEIVINGNHKSDETFQTGILYFNKMADIVSTNVTTTPAALAITGTAAADQLTRTENLEETKTVPFEDITSDSAAFEGYGAIISREPTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2R5</accession>
    <name>A0A183H2R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1775</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000901">
        <property type="protein sequence ID" value="VDO30744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2R5"/>
    <dbReference type="WBParaSite" id="OFLC_0000177401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000177401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000177401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000177401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9423" checksum="D67201524352870E" modified="2016-09-07" version="1">MLWERIRDICAYNRGYCNNMEEKEKGRDYCDKSLTSGVTSFQGSCRQRQVLSKRRKDSPGETSLAILVLNFIRISVSSQGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2S3</accession>
    <name>A0A183H2S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1783</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000905">
        <property type="protein sequence ID" value="VDO30765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2S3"/>
    <dbReference type="STRING" id="387005.A0A183H2S3"/>
    <dbReference type="WBParaSite" id="OFLC_0000178201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000178201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000178201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000178201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="9953" checksum="1EFA22A70A7753D8" modified="2016-09-07" version="1">MNVLLFEERHICIRCGGEGGSCSPPRGLSSSQLQLPPFVYSSHSASVSPQCTSPALFAGDVPGTSGQDDRRRISRLVDGRSNSLVVTTVSDDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2U2</accession>
    <name>A0A183H2U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000920">
        <property type="protein sequence ID" value="VDO30840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2U2"/>
    <dbReference type="STRING" id="387005.A0A183H2U2"/>
    <dbReference type="WBParaSite" id="OFLC_0000180101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000180101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000180101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000180101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12428" checksum="F8EEB44C755E0FE0" modified="2016-09-07" version="1">EAGRVGQLTTALVLVQLARDDAVSAAKSLQKSFKCEDFEISEDAKICSALISAFESGDNNSFQQVLQRPILRGMDNEYLRLMKELKASSELSGRNGNDNDAREEGGDGSDEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3L1</accession>
    <name>A0A183H3L1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2071</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001119">
        <property type="protein sequence ID" value="VDO31769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3L1"/>
    <dbReference type="STRING" id="387005.A0A183H3L1"/>
    <dbReference type="WBParaSite" id="OFLC_0000207001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000207001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000207001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="8">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO31769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000207001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14483" checksum="712E4163482727DC" modified="2016-09-07" version="1">MFEDDEEMEEAPFEEDEEISSEQWQEACWVVISAYFDEKGLVRQQLDSFDEFIQMNVQRIVEDSPPVELQSEVQHFSGDIENPIKFALKFDQIYLSKPTHWEKDGAPTPMMPNEACFFFLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3P8</accession>
    <name>A0A183H3P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rx_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2108</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001146">
        <property type="protein sequence ID" value="VDO31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3P8"/>
    <dbReference type="STRING" id="387005.A0A183H3P8"/>
    <dbReference type="WBParaSite" id="OFLC_0000210701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000210701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000210701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000210701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21912" checksum="83842CD99C94C39C" modified="2016-09-07" version="1">MQVLLSALGNTLFLGSDSVADAVAREVAAFSEASGLNIRQLQGLIRREEHIAPNPHLNNRSSSGRFSSIPAPTILSEMRARKSVKVQVKGNEQHDGDYTDFINEVFRATEVDSLLDVKYVIKKRYYKPYDLKTDEQKEAVLIPWLEEQDALDLSVDMSDAQLDGEIVELLKQIPEFVDDVLDKYTMDSLLIWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3V3</accession>
    <name>A0A183H3V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2163</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001184">
        <property type="protein sequence ID" value="VDO32066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3V3"/>
    <dbReference type="STRING" id="387005.A0A183H3V3"/>
    <dbReference type="WBParaSite" id="OFLC_0000216201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000216201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000216201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000216201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="649" mass="74623" checksum="09D0A10673B3D626" modified="2016-09-07" version="1">MNLFGTTKTESRMIVTESTVEDRTISETSPVSMSSQDSFTTHFQKPQFTLPLNDVTIWETEELQLKCIVTGEPMPTIRWFCNGKEIQADNRNTFTIYEDGIVMLKITKGDKEGLYICEATNGIGSAQTRSFVRINSSEVSLTTTMELESAMESAEAVLLSFSTSNFCSTADIAGKESEMVEQDLKERKSRKIFEEEITTDQYIPAGTLNYLIEAVALTITIINYKLSAQVKLTAEARGIKEEKLFKIIIEEDIIRTRTYLRVVLRSARELWTLQGRTIERLPYWSQETINERVEFEKIFQDDELHEFLKDKDIIERYVKLLNAAETSKSNEKRETRFKLHQFEDAPKTSEKRQLEIREEQSGNLVEDNGVFTVVHCIANAMSYAAEAYVILITRHRYEATFDFRSAQHRMIAESEEFEASIEDTIKRQKYFPQSLLVLPHFIQSFALFEKDFSTGLRCCVYGLPTPSIRISHNGCPILRNNRFFHVVYKSGVITLYMQHILEGHYVCEAINPAGRAITECYIRIEDAWDEIQHRKIRRIRVENTKPTDKSCQNDEILQTSETSMSQFEYEQSNQRSDGISGIQVNEAMELTASSGETLTKYSTKFKEAVEKDIQETKVSKSGICEEINKDVLFERKPATSFMEVSVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H582</accession>
    <name>A0A183H582_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001556">
        <property type="protein sequence ID" value="VDO33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H582"/>
    <dbReference type="STRING" id="387005.A0A183H582"/>
    <dbReference type="WBParaSite" id="OFLC_0000264101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000264101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000264101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF7">
        <property type="entry name" value="BURSICON SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000264101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45725" checksum="66884DD2E65B52BD" modified="2016-09-07" version="1">MLLSTASTVHSVMLTTDQQQQDEVAACTQTDLSSASESELLNCRRHYRSLLQKVNGELARVSRQKPYSPVSASLPDHESIFFLDRLKAIRLAREEELNRTLTETIDGEIFEKRRRPFVPRRNNTVEECRQLSQQELVTELKQKGTYNPDLMAWDASGIIRFLDRSIGDQYERESKTRLSVEETVERNVEALERILSELNIECDVRSPSVISRLQNLTSTESRRTVISPSIRMMDSELERNKRGTAESVIDSLIASGAVDAHTRGDLIMRKRQKLIGDVHVIPFGCDKRGGEEDGYLRLCGACQAIRRLPDTFFPPFINEVMCDDDKACLYFYDFRAFAFLLNYLEIAHGKCTQKHMNFVVLKNVGTDDCQIWQKFNLNVRVSCECFVGLLFCYVIVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5R3</accession>
    <name>A0A183H5R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KIX_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2823</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001722">
        <property type="protein sequence ID" value="VDO34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5R3"/>
    <dbReference type="WBParaSite" id="OFLC_0000282201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000282201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000282201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000282201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="693" mass="77503" checksum="AC011EF35F592241" modified="2016-09-07" version="1">MAFQGVQFQIQTTPDEAPWYKQVDPTMSLDKLLSELYSLFRILYYRLKSDLIFCLELTEEFSRIYKTHGESLNIKKYAMRSSLRETATPQNPNQPQQQSLQQPSSQQQRQGQNQITPSIATLPPPPVAPQLNAAVTVKGTEPARRIDLSDYKLRNNAAHQQQQSMSSQNSVAQTQRRNFMRPDVLPQTTGKGLDLPLPPIIANGKFDYLHFKMYFKNIKIICFFFCMCACIINIILEKQLNLSKPPDQVTAKPTEAAKIVQMSKSGTSKPTGLQKPAITNVSKTLHPIRQLTGTNEQERYKKPKPDDEKDLKHRKTEKTSAEGSHHRKRFHENNVAVSQTDNSSTTATAIITNVTSTSKSGTPKPTERHNPVISVNHVTSGGYSITSKSRDEAASQSLKRDSNSTSTNTRGRDESISSRQRDDMTAVKKARQTAPLIALLPTPPSSNTASVISTNSQNSKYNLSTVQTNRSNHIGEGTHRTNATTNWSVTNDYYMGPSSNNASRFSQLSGSSNHRHYSSSSAVRIKSREPLLSTPDPGNSYYKRSRPRPPSPITATTSNAYRQSQRSSSPGNRSGSSYSSFTRCCCRQYVYKITPCRSSPIYRRGEWRRRSWQSRMSYSSDTGTSLANASSILDSFLIIPFHQLLHFLSFMATLCFYFAIVVCLLSNSTHILSALPPPPLPPPNEELEDGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5V7</accession>
    <name>A0A183H5V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001757">
        <property type="protein sequence ID" value="VDO34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5V7"/>
    <dbReference type="WBParaSite" id="OFLC_0000286701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000286701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000286701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000286701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20265" checksum="A30612BE45524C3B" modified="2016-09-07" version="1">MLWRHSTAIGRRQQRFNQNFILFLITNIPIFTWATTEWFGDSRANMNPARSPPFYDVIYDVSECPEGLESEAIPEYAYFGPMVASMDALRHAECLDNCIKHSKCVAENGFCELLSESQLDNPRLMRPFKQAIYFENIQCRTGKDIIDEDSGKLLFEIKFFILLGVKELTCCSRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H620</accession>
    <name>A0A183H620_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="8">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2930</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01001821">
        <property type="protein sequence ID" value="VDO34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H620"/>
    <dbReference type="STRING" id="387005.A0A183H620"/>
    <dbReference type="WBParaSite" id="OFLC_0000293001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000293001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000293001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="14">
        <location>
            <begin position="62"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000293001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45383" checksum="0801D7F9414FF748" modified="2016-09-07" version="1">MSEKQEDSDQKKVDKRESSPLMESSKSRDDKNLVSSSSSILEKLVTKLGQLTTKEKGKNIKQKLSSLTIEGVAEYIKSEAKNVIVLTGAGISTSAGVPDFRSPGTGLYDNVSQYNLPDPMAIFDISYFKKNPEPFYKLAKDLFPSHLKPTPCHYLIRLMDEKGLLLRWYTQNIDSLEFVTGINEEKLVTAHGCHHTSTCLSCRAKFDLNWIMNKVFVENVKVAYCDKCGGIVKPDIVFFGENLPPRFFNYSIRDFPKCDLLIIMGTSLVVHPFAGLVDEVNDDVPRLLINLTEAGRNMSSFFPYGGNSGLCYHNEDNYRDVFWQGKTDDGAWKLAELLGWKTELEKLIETELKKIDDKEQKDKKNFRSTAKRLDSNNDAEKTNRKSLERDKSVNEKLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H664</accession>
    <name>A0A183H664_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sen15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2975</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001857">
        <property type="protein sequence ID" value="VDO34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H664"/>
    <dbReference type="STRING" id="387005.A0A183H664"/>
    <dbReference type="WBParaSite" id="OFLC_0000297401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000297401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000297401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000297401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11635" checksum="109995EA95595C20" modified="2016-09-07" version="1">ASKTQRKFSTCPADCSYAVIVEAKRHAFVYWQPSTPTSDLRNRKTGHQIAGVAKQQLISLSKPSEFCDTSAVMENIIGVHADNEFLFILTTTDIFAVLLKDSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6A5</accession>
    <name>A0A183H6A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3016</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001891">
        <property type="protein sequence ID" value="VDO34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6A5"/>
    <dbReference type="STRING" id="387005.A0A183H6A5"/>
    <dbReference type="WBParaSite" id="OFLC_0000301501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000301501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000301501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF96">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="126"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000301501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24512" checksum="8D9960175092F62A" modified="2016-09-07" version="1">FSVERFPLLVVIIKEKSVILPINVAWGCDGPEQVVNKLMEGLEEYQRIKNAEAAEERERIEREKIREEQAREYEQSLAQDRARQERLEREKNEQKAEEERRAKEEQDKTKRLQELAASLPMEPAAGETNIAIVRVRFPDGNMQLRRFRMSEPLRNIALFVESKGYSLDTHRIWTSDMPMKNVVESYDLNRSLADIKWPVREQITVDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6U7</accession>
    <name>A0A183H6U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3209</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002075">
        <property type="protein sequence ID" value="VDO35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6U7"/>
    <dbReference type="WBParaSite" id="OFLC_0000320801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000320801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000320801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF39">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552401" evidence="8">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="34"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000320801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28558" checksum="60E843B1A2766EE9" modified="2016-09-07" version="1">MHINFNLLVIITVLSNGCFSVTYPNAILEKPIVTCEPERIFIQVRTSKSNPSHIYAENHIGDPDCVSRNTNWLRLSLGNCGMTVKKTKTPAATTYRICITVQLHPLFITDSDRSYCAQCVYMDSNVIEDLQQSLLISDSAPSNLEPQSDLVTPNCSYQIRRNSIDGPLVHYALLGETVYHNCYVEDAEGNQILIINSDGCGVDQYVLQTPKYSVDRRTASQKMNVFKFAGKAITRFNCQIRICPSSNDSCQVSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7W3</accession>
    <name>A0A183H7W3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase-stimulating G alpha protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3575</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002436">
        <property type="protein sequence ID" value="VDO37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7W3"/>
    <dbReference type="STRING" id="387005.A0A183H7W3"/>
    <dbReference type="WBParaSite" id="OFLC_0000357401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000357401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000357401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000357401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9771" checksum="7065F7D31F289205" modified="2016-09-07" version="1">MENNLLRKINKQIEEQLQKDKQLLRATHRLLLLGAGESGKSTIVKQMRILHISGFNDKEKKEKISDIRKNVRDSIVVSLFIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H914</accession>
    <name>A0A183H914_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3975</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002849">
        <property type="protein sequence ID" value="VDO38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H914"/>
    <dbReference type="STRING" id="387005.A0A183H914"/>
    <dbReference type="WBParaSite" id="OFLC_0000397501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000397501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000397501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000397501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9433" checksum="EF6D5C9489335E40" modified="2016-09-07" version="1">MIIPIRCFTCGKVIGNKWDAYLGLLQAEYSEGYILLKIGEAMILFTGDALDALNLRRYCCRRMLLSHVDLIVKLLDYHPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H922</accession>
    <name>A0A183H922_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3984</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002857">
        <property type="protein sequence ID" value="VDO38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H922"/>
    <dbReference type="WBParaSite" id="OFLC_0000398301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000398301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000398301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF88">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000398301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22268" checksum="6D8019D1EA11EF56" modified="2016-09-07" version="1">MLNKWRNIVDEYREFNVTVFMDDAIFLDLIDNMTTDAWQSALGLLICMAFISFIFLYDAFTVIVVSTAIVSIMTGIIGLMILMGFNLEPIMMAAILIAMGSTTNQHLMMREKLRICFSSVALPALQASISTSLCLLGLLFKDLYIAQVFVKTMLLCISLCVFHGLLIIPCMLVLVDHLSQFCKRLRRRKVVCSTITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H992</accession>
    <name>A0A183H992_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4054</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002934">
        <property type="protein sequence ID" value="VDO38719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H992"/>
    <dbReference type="STRING" id="387005.A0A183H992"/>
    <dbReference type="WBParaSite" id="OFLC_0000405301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000405301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000405301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000405301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9678" checksum="DEEBF2589F6DF8BB" modified="2016-09-07" version="1">MLIIAICTILGCKTRISFIYLPIPPSLVLLVAAYIFYDLRWKGRLLPPGPTPWLFFGNILHFMFYESIDDMFLTWKQKYGKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9M7</accession>
    <name>A0A183H9M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4188</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003084">
        <property type="protein sequence ID" value="VDO39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9M7"/>
    <dbReference type="STRING" id="387005.A0A183H9M7"/>
    <dbReference type="WBParaSite" id="OFLC_0000418801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000418801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000418801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000418801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10268" checksum="6ECFD60A1110A665" modified="2016-09-07" version="1">MVVNVYATSATIEQCSRNELLAFVNNFLRSNFTRIEELSSGAAYCQLTELLFPGKISLKKVKWNSRNEVDWIANWRILQTAWKDLGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA67</accession>
    <name>A0A183HA67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">W2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4379</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003294">
        <property type="protein sequence ID" value="VDO39801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA67"/>
    <dbReference type="STRING" id="387005.A0A183HA67"/>
    <dbReference type="WBParaSite" id="OFLC_0000437801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000437801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000437801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552448" evidence="2">
        <location>
            <begin position="18"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="396"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO39801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000437801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55161" checksum="D8BBC9A1D2B2F823" modified="2016-09-07" version="1">MFDYWRVLFDSLVVVLCQNCVSIGDAIREVHSRSIIKSDFLLLTSPMTIAATDLSAQLSYFREIRKDKNNVMLIVYGEWKNECPIIAHEKKNGKLIFYHQKDDASKLDIDKGVFTIDSVVCNNLRDTGITFCSINVLSQFSDNFDFQYKEDIIREILVNEEILGQRIYITVLPKQILAFCIYDYADLLLMNKLILQRFFFPLVPDNISYSTYICRRNNIYTPSESLEQNCQVKRNSPLIFDGANVLLGKNCSIGLNVVLKNVSIDSGTFVGDGCEIVNCIIGRNVSIGTNSCLSECYIADDVIIGSNVILFPKCVLSSKVKIPDGRKLPSESVISTESYEDDNEEFECIPSEYGFEWRVKNGNGFWHAAYSKLQLRDVSVASRDINDSKDIDQTIGEKEVDSVDRFYEEVKESMDRIAEQKECDDQLIKNLILEINSSKLAYNITMEDVARNVFLSFLSLSDTFSELQKVGLRINSLQKMDHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAB0</accession>
    <name>A0A183HAB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4423</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003348">
        <property type="protein sequence ID" value="VDO39958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAB0"/>
    <dbReference type="STRING" id="387005.A0A183HAB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000442101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000442101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000442101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000442101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22610" checksum="310924B15E54FAF5" modified="2016-09-07" version="1">MLAWNILIYTLYAKSLPFDICCRVWDVFLRDGEQFIFNIALGIMRLYESELENMDDFDAVVHFLTHLPQSMNINQLFDATEPFMKSSSSGATSEHGNGKKRSFQQIHSDVSERIAQASVMTGGNCKFDLFSSPIDTSHENREPSIRDCEGRSCKSVGINSVNENSQNIAEQQASTLRFNVYNMKMSKSLTEFVVCYRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAK4</accession>
    <name>A0A183HAK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4512</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003458">
        <property type="protein sequence ID" value="VDO40199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAK4"/>
    <dbReference type="STRING" id="387005.A0A183HAK4"/>
    <dbReference type="WBParaSite" id="OFLC_0000451501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000451501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000451501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000451501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14075" checksum="D2DAC313B49F039F" modified="2016-09-07" version="1">METEKQYDTNCGEKGVQMSGGQKQRIAIARALVRRPAILILDEATSALDAESEHIIQDAIAQCSKDKTVIVIAHRLSTVENADQIIVINKGRVMQQGRHEDLLRQDGIYRSLVHRQLLGQTSNKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAT2</accession>
    <name>A0A183HAT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4594</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003559">
        <property type="protein sequence ID" value="VDO40440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAT2"/>
    <dbReference type="STRING" id="387005.A0A183HAT2"/>
    <dbReference type="WBParaSite" id="OFLC_0000459301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000459301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000459301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001072">
        <property type="entry name" value="Transcription factor unc-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000459301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36950" checksum="5386DD5D4CC5518A" modified="2016-09-07" version="1">MSQAGAMSNGKPAYSYKTTESGQLQPVAFPQDALMGPGIPRMARKVHDLQHGEVVCAVTISHQNRHVYTGGKGCVKIWDISRAETSKNAISTLECLKDNYIRSCKLFNDGSTLIVGGEAQTITVWDLTTEKVKIELDSEAQACYALAISPDNKLCFSCSADGKIIIWDLDSKKMIHCLPGHQDGASCVDLSNDAVRLWSGGLDNTVRSWDLRERVQLQQHDFQSQIFSLGCCPCDDWVAVGMENSNVEVLHVSKPDRYSLHMHDSCVLSLKFAHSGKWFVSTGKDNMLCAWRTPYGASLLTAKESSSVLSCDISFDDKYIVTGSGEKKATVYEVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB48</accession>
    <name>A0A183HB48_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS4710</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01003710">
        <property type="protein sequence ID" value="VDO40815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB48"/>
    <dbReference type="STRING" id="387005.A0A183HB48"/>
    <dbReference type="WBParaSite" id="OFLC_0000470901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000470901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000470901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO40815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000470901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38378" checksum="664E9F1886ED3395" modified="2016-09-07" version="1">MNAVVRSYVRMALYHGHKEMAWGDVTNWVMYGGSFLGTQKQLPDKIMDQVAAGFEKYNFHGLLLVGGFEAFHSCLLLSHARDKYPSLRIPMCVIPCTISNNVPGTSLSLGSDTAVNEICQMIDKIKLSATGTKKRIFIIETMGGFCGYLATISALASGADNAYIFEEHFNVHDIMDDVKVITHKMRTGVQRYLIVRNEYANKNYTTQFVSQLFAEEGKGAFSTRTNVLGHAQQGGNPTPFDRNLGTKLAARALEFIISQISNCADPKTGSVNAVSPGSAALLGLMGRRTVFTPVEELSLQTDFEHRVPKHQWWMKMRPLLRILSKHDSKYETEAMLVPEVESEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBU6</accession>
    <name>A0A183HBU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein heavy chain 7, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4958</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004041">
        <property type="protein sequence ID" value="VDO41589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBU6"/>
    <dbReference type="STRING" id="387005.A0A183HBU6"/>
    <dbReference type="WBParaSite" id="OFLC_0000495701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000495701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000495701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="1">
        <location>
            <begin position="113"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="2">
        <location>
            <begin position="259"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000495701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48565" checksum="121F775F42F85BB8" modified="2016-09-07" version="1">MIYPVEKIDWIDNERKLAVAKLQKYLPKLFNNLRFTDQGLWSEFARAINCETTFPHAIDAVITPFQKLLVIQAIRPERLYSAIINFVINVLGIPSINPSPLDLSSIYKSESNENEPIMILISPGADPSQKFLLKELEELARKHISKAKFYQISMGQGQRQAALEAIRTCAASGGWVCLKNLHLGINDLAAIEKEFLSSKRDPSFRLWLTSESNEHLSPHLLQTSLKIVYEAPPGIKNNMKRIYAQWRQSELNFNAICLQSLFMLAWLHALLQERRMFIPQAWTKFYEFSNSDLRVAKKFVENVTKDDKTVDWELLCGLLKTVAYGGRIDNDFDMNVLVVYLKRYFNSSIIGMNGSEIAHNISLPFSSNIADYVNIINTNIPEEDNPALFGLPLNISTAYEMAETSKTIRQICSMQIVGTTEVTFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC92</accession>
    <name>A0A183HC92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004218">
        <property type="protein sequence ID" value="VDO42079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC92"/>
    <dbReference type="STRING" id="387005.A0A183HC92"/>
    <dbReference type="WBParaSite" id="OFLC_0000510301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000510301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000510301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000510301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="47096" checksum="FC0906F7B98D60A7" modified="2016-09-07" version="1">MVNLLASRNGKKDNRTQLQQGSKEMKKTRSFHHNRRLMSSSEEEELIGNESNDDDLKTPQTTASWRGQNSDTEVVEDTKKISEVPSRSVRAIPNIIHKDLTFEERLQTLTDSDSSDQKSDSKQPVKWLCKPRLDSFLKQDDTHITTQPTIRRGRRKRAVISSSSDEKPESDEEKLMREAVDIGGNVTTLLILAVSCKVPVSLKMMVKRAKKHRKYLNSSSEESESDEHYDSDSSARIGKSDDSESSQIMQRRSHRNASSSMILKNCCVTFFNEANRNMLMETPRINDKVADFIISNRPFRDYEDLESRLLQCPRGSYAAEQYLDFLENRSILENILDDCRRHSEEIYSALDSIKSKQLQMKPKLLSEECKLHPYQQIGLNWLMMMHKLKLNAILADEMVIIYNRRESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCE5</accession>
    <name>A0A183HCE5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5157</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01004287">
        <property type="protein sequence ID" value="VDO42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCE5"/>
    <dbReference type="STRING" id="387005.A0A183HCE5"/>
    <dbReference type="WBParaSite" id="OFLC_0000515601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000515601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000515601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="78"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000515601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29956" checksum="80800C81B580E088" modified="2016-09-07" version="1">MIILGSCKDIRKFNKNHPVVNQRITLHDGSPLFGHEVYGENGKLVTEFLGIPFAEPPIGQLSMDTYFGDFQGATMWNSNVPVSEDCLYLNIVVPGQINRKARLPVMVWIYGGGFWSGCISLDKFFFSEENVIFVAMNYRVSVFGFLYMGREEAPGNMGLWDQLLALKWIRKNIDLFGGDPYQVTLFGESAGAAAVSMHLLSPKSSPYFQRAIIQSGSVTAPWATETKEVAIARSVILYDDMRCGNMSKDPQSWDLDKVMASALKKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDE1</accession>
    <name>A0A183HDE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5503</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004764">
        <property type="protein sequence ID" value="VDO43389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDE1"/>
    <dbReference type="STRING" id="387005.A0A183HDE1"/>
    <dbReference type="WBParaSite" id="OFLC_0000550201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000550201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000550201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000550201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10278" checksum="21883AAFDCCAB5FA" modified="2016-09-07" version="1">MEKVVNYEQEKSTESSDITNEGAINLAPGAERYHTTLQNGGTAGACGINHPETGVNVLDYSTDFPELPDKLSACASQLLGGVWNKPPAVRSERTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDH3</accession>
    <name>A0A183HDH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger Ran-binding domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5534</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004809">
        <property type="protein sequence ID" value="VDO43460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDH3"/>
    <dbReference type="STRING" id="387005.A0A183HDH3"/>
    <dbReference type="WBParaSite" id="OFLC_0000553401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000553401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000553401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999:SF17">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000553401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32496" checksum="C11AAE789D999158" modified="2016-09-07" version="1">RDTAHHQLLSPNFRCGNVNWARRTACNICNAPKLGDLEVRTGYGGGYMDRQNVEYIEREDDEEFDEFGRKKKRRKLDNKIEEEQKITESEESAKYNERGSDEEKEKIKEMKIDTKEALSGDNDEEMEEEEEEEDENDADLDKYDLSADEFEVENLKAKIAARKAALASSTTEIQVRSESRCSSDCSCSCSGGECSCEESESEEERKRFNRDVEREKEKGDIRSKDRDSTRDKEKEKERDRERRDERERNRYGHSQCKLVLLLITFSLFCFCNYQIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDJ3</accession>
    <name>A0A183HDJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-complex protein 1 subunit eta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5556</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004839">
        <property type="protein sequence ID" value="VDO43528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDJ3"/>
    <dbReference type="STRING" id="387005.A0A183HDJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000555401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000555401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000555401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO43528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000555401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18437" checksum="612D59F9E47E0FF5" modified="2016-09-07" version="1">MKRCDNRCCNFFTWIIFIWKNLCFYNRQMMMNAPIILLKEGTEAKFGKQQIISNISACNVIADSVRTTLGPRGMDKLVIDSKGKTTISNDGATILKLLDVVFPAAQVMVDIAKSQDAEVGDGTTSVVILSAELLKRSKPFIEDGVSPQLIIRSYSKACEENHLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF51</accession>
    <name>A0A183HF51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MEIOC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6111</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005627">
        <property type="protein sequence ID" value="VDO45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF51"/>
    <dbReference type="WBParaSite" id="OFLC_0000611201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000611201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000611201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000611201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="40977" checksum="0746E46D739A5F57" modified="2016-09-07" version="1">DGLSCFWTDPSFVSYGVGDPYSYQYNNFSHFSSHIQYYDPETDGYYFEMPSVDGWKKRQPHSLSSAVMPSPTGYSSNRMMMNPNTISVISAVPNITDAMDVPRTSYGAALARGQLPPCTVRTNNAVTSTSGNMNEVLKDTFSSADLSFSTLSSNEDFGAASSALLFDKASAEWDNKGNNQGNCDTQKLFSYADIVTSPRDTSTTTNVDDIENNPPLQQIRNIHHKRPETLELHNFAEENDVVRVTNEQDVKRSGLTNFNADKFIADLPFNSTDRVLRDLAALKTPSAVPVCNMDSPHTPSVMKGLYSPLGIPNQDIDAYSAIYDMELVLSQILSCADEKEWVPERASAGTSKLNFWRNSGLVAGVAGVSCDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFE7</accession>
    <name>A0A183HFE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6209</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005773">
        <property type="protein sequence ID" value="VDO45790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFE7"/>
    <dbReference type="STRING" id="387005.A0A183HFE7"/>
    <dbReference type="WBParaSite" id="OFLC_0000620801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000620801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000620801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF139">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO45790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000620801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12390" checksum="BAA600531C3E9519" modified="2016-09-07" version="1">MIGSYVPYKPAIFIDAGIHAREWIAPAVALYIISKLITEYGKNPNITHMVDTFDWYIVPVANPDGYEYSMTTDRLWRKTRSRNITVNKWCVGADANRNWGYRWGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFR5</accession>
    <name>A0A183HFR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6327</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005955">
        <property type="protein sequence ID" value="VDO46171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFR5"/>
    <dbReference type="WBParaSite" id="OFLC_0000632601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000632601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000632601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000632601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10683" checksum="DC97361B584DAD42" modified="2016-09-07" version="1">MEMNSSESLPKSKNNINKSCDHLADGSGSPKRRSGRRMYSNSINCNSSQSLCEGCSTDNNVCHYNGPASSRFGTKKSSSNQKEAFDSNSTSLSVSISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGF7</accession>
    <name>A0A183HGF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006318">
        <property type="protein sequence ID" value="VDO46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGF7"/>
    <dbReference type="STRING" id="387005.A0A183HGF7"/>
    <dbReference type="WBParaSite" id="OFLC_0000656801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000656801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000656801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000656801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18542" checksum="69C716B9CDFE6669" modified="2016-09-07" version="1">MLPRVPKPTTNFHSSTRDSSVTLMLLAIVAMFLTCNGLAFCNNIIEILIFVDKIDNSENESAFEKSVEIANILVSLNSSTSIFIYLIFSSKYRLIVKEYLGLKKIHKVRSIFRAKAYGGTLTATGIAVRHTFEYPFFREEISQTPARLRIFSGLRFPASVHRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGP3</accession>
    <name>A0A183HGP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6655</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006455">
        <property type="protein sequence ID" value="VDO47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGP3"/>
    <dbReference type="STRING" id="387005.A0A183HGP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000665401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000665401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000665401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="7"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000665401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="52454" checksum="BA74E99D54ECF8D6" modified="2016-09-07" version="1">MNPPKFEKTEDMSNLTFLNDASVLYNLRSRYSAMLIYVRLLPKGSLKHHSTYSGLFCVVINPYKRLPIYTNSVATMYMGKRRTEMPPHLFAVSDEAYRNMLVDHENQSMLITGESGAGKTENTKKVIAYFAVVGASQNKGQDQGEKKITLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSRQGKVASCDIEHYLLEKSRVIRQAPGERCYHIFYQVFSDFNPTLKKDLLLDQPLKNYYFVAQAELTIDGVNDKEEHQLTDEAFDILNFSPEEKMNCYRLVAAIMHMGCMKFKQRPREEQAEPDGTDEAEKASNMYGIDTEEFLKALTKPRVKVGTEWVSKGQNVDQVTWAVGAMAKGLYDRIFKWLVTKCNKTLDQKGLTRDYFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYEREGIQWTFIDFGLDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH35</accession>
    <name>A0A183HH35_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">40S ribosomal protein S29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6797</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006674">
        <property type="protein sequence ID" value="VDO47940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH35"/>
    <dbReference type="STRING" id="387005.A0A183HH35"/>
    <dbReference type="WBParaSite" id="OFLC_0000679601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000679601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000679601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO47940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000679601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9176" checksum="529FABE98E825CD6" modified="2016-09-07" version="1">MYDVKIEQSNQSQDGSSKFMVFASAQVWSWFSRVCSNHHGLIRKYGLNMCRRCFREYASDIGFKKNLGYLENISSSSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHJ1</accession>
    <name>A0A183HHJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6954</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006943">
        <property type="protein sequence ID" value="VDO48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000695201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000695201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000695201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000695201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39714" checksum="11566C1919636F6D" modified="2016-09-07" version="1">MSKNFDYPSDLIVPSQIPSDTSESPLSYSNDSSKQPKSILKHRSVSSCNTNGDTSKRSVERVQINDSNYKEKRQQHHDQSYDSSGRIDQSSHSSNPNSDSIDRENRLYQVMQENLRQQNLRPQTPRHLPQASFNGPFFTLEEVHTEQQRFNFKYIEIATVKITKQSRGIHQIPIGEYHVESDHQLIRRQQQDSANNSNHKLKSDSRSKSVSVMEINRMEPEKLQNNEIGESFVHWSSPPSKQERERAQSVPPSLRTRNITDPDRIDEYHRQKELELEAIRRKEEETIFWGKKQVIAYNLIENFVISPRNFYNFWISGNFVFLGFSIMSLSHENTDENTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHP7</accession>
    <name>A0A183HHP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007038">
        <property type="protein sequence ID" value="VDO48852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHP7"/>
    <dbReference type="STRING" id="387005.A0A183HHP7"/>
    <dbReference type="WBParaSite" id="OFLC_0000700801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000700801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000700801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="1">
        <location>
            <begin position="102"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000700801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27681" checksum="ACA4139EB4A981B4" modified="2016-09-07" version="1">MAAGSKILEKMLFDEAEFSSPILKKRKGSDLNYPVVTIQFPDVDPVAFQTIIDYFYSDFDETAIKIAESAVLNTLYAAKKFEIAALEKHCVELLGELTPSLAVALLEQAIKFGSEELLDRCHQVIDERSDEALSSDSLTATSIETLNKLVKRSELSPSGELSVFKAVCNWAEAECKRRGIDETPENKRLVVGDVLNDVRFPTMTVEELGEAANSGLLSDLEIGILFRYVTSTVHMGIDLPFPTHGKRNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHW4</accession>
    <name>A0A183HHW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7074</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007137">
        <property type="protein sequence ID" value="VDO49191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHW4"/>
    <dbReference type="STRING" id="387005.A0A183HHW4"/>
    <dbReference type="WBParaSite" id="OFLC_0000707501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000707501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000707501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552545" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000707501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32369" checksum="65F7A021CD0CE4C6" modified="2016-09-07" version="1">MFIAQCALIIVAIWKSINGASVPVWNRNFGSEIYLLKDGNNAVYDLRTQRLVSTIKQKLEFNERLLILFCVRRCYPTQSQIPRWIREFSKRNNLTARQEHFTYQFYDNRRNNRIFNDQLIHNGSKPYLVYAIDGQLFRYEGNINNKEEFFSFLRSHELLNTEIVSTWEHLELIINKAQLCHGEKHVLQIVDNNRCPMDHYELVVRAFDGVANYSFYEIMMPLTIDMDIELYTRLPKLPSSCQLILLLQNGGYLWMSADADLHEVFLNFSILVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI20</accession>
    <name>A0A183HI20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7131</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007234">
        <property type="protein sequence ID" value="VDO49471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI20"/>
    <dbReference type="STRING" id="387005.A0A183HI20"/>
    <dbReference type="WBParaSite" id="OFLC_0000713101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000713101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000713101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO49471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000713101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13553" checksum="C7D849C027A08DF4" modified="2016-09-07" version="1">MAKISWKERFYSSLGMLLHVLFVACPLDFWYWFRSNLKSVNGRTVVITGAASGIGKRLAELFAIDLGAKVAILDINHPGAQETVEEIVESGGIAQCWKCDISQVEEVNECARQINAIFGTMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIK5</accession>
    <name>A0A183HIK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007547">
        <property type="protein sequence ID" value="VDO50369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIK5"/>
    <dbReference type="STRING" id="387005.A0A183HIK5"/>
    <dbReference type="WBParaSite" id="OFLC_0000731601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000731601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000731601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000731601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27963" checksum="EEC5D3A3F315B914" modified="2016-09-07" version="1">MTENVLSFRGSNIGIPNTNINVPSTEDSATSFRFGKVKVNNNDDEIEFLGSNHLINDTNGSNNKAQNRHGDDNDVVFVAETVPTDFMANVRSEVGPTTEPVPSFFKRSLEIAPTTSTVKLATESDEMAINNILEKVIDAVILPWPYQTTSDESGSSTAAFNANEANVTCSILCEQNSASENERSIRTVEEELTSAKAACVSMDVDDDNDVLIVDESKNENIGVDEEVLKKAKRISDKSGDPDLEVIGNSERFLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIS6</accession>
    <name>A0A183HIS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7386</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007685">
        <property type="protein sequence ID" value="VDO50751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIS6"/>
    <dbReference type="STRING" id="387005.A0A183HIS6"/>
    <dbReference type="WBParaSite" id="OFLC_0000738701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000738701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000738701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000738701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19144" checksum="1F4568B1764D0D03" modified="2016-09-07" version="1">MVDSDDTYEMSNTARKRLSSLIRSNTVDYSHSSEHYMDYYDSISRKFDDDFDEDFDDDEMLPESHDDDEKKQQQQQQPIHYTMIVPAKERLPIEDGKIMEKSVKSVPSHHLEQITKLSTREESFSSSESRSQLCPSDDTVSTGLSEEDERLISVPNITCKFNGGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK80</accession>
    <name>A0A183HK80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008544">
        <property type="protein sequence ID" value="VDO53024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK80"/>
    <dbReference type="STRING" id="387005.A0A183HK80"/>
    <dbReference type="WBParaSite" id="OFLC_0000789101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000789101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000789101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000789101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18732" checksum="F9AFB5715615E00F" modified="2016-09-07" version="1">MEFLDLPSDLLHSFCSHSTVLLPSLIQKTHKMLIANCFVYFENFGALLAEIEKHAYSSKELWRLHAAHALMMLSCTSCTMLIHSPSYRYRFISCCRSLLLDEVDYIKRIAFRVVNACGGGTTLSYLWDPTMNLKVRTTKEIRKTRKASQKGTKLERSIAFKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLK8</accession>
    <name>A0A183HLK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009408">
        <property type="protein sequence ID" value="VDO55341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLK8"/>
    <dbReference type="STRING" id="387005.A0A183HLK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000836901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000836901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000836901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000836901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9959" checksum="CD22A0311E96B1B8" modified="2016-09-07" version="1">MRNRLTLSFVDGNLKCELNWGLRSFHCRVPLQREEPPTARVVPRVWNGQYGDKHQFRCITTGSPEPTIVWSGPDGERLPDGVADIGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLL2</accession>
    <name>A0A183HLL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009412">
        <property type="protein sequence ID" value="VDO55361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLL2"/>
    <dbReference type="STRING" id="387005.A0A183HLL2"/>
    <dbReference type="WBParaSite" id="OFLC_0000837301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000837301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000837301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF26">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000837301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15050" checksum="E368CFDD81DF0401" modified="2016-09-07" version="1">MFFRQLLQWKHVVEIAAVDCADNQNLKLCREHNVQAFPTLKYFKYMSTNANDGVDYRGNAHNLNGVPLDIAEFVYNDWIYQKPVEWPSFQTSDNYVRLEDILPTVPPVTSLLAVIVENNPSKVAWAVSDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HML7</accession>
    <name>A0A183HML7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3452 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010090">
        <property type="protein sequence ID" value="VDO57065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HML7"/>
    <dbReference type="STRING" id="387005.A0A183HML7"/>
    <dbReference type="WBParaSite" id="OFLC_0000872801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000872801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000872801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000872801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19342" checksum="F807E1D4D80852CE" modified="2016-09-07" version="1">MGKQLTWYACAVYLSMWQGNPLERMVPKKYSLAELLRICKISVLEFFEKVTKWVEMVNGPRRLKDHINRVQSSLAVVAVVFKKLLPIFRKIFAPPCSNDDDEKAVNCKKLFSLIWTLFIVMRKQFNSDDLMNSFHLLLCTVDFVFQDLRRSELTCLLDGDFSNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMN7</accession>
    <name>A0A183HMN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8749</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010136">
        <property type="protein sequence ID" value="VDO57199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMN7"/>
    <dbReference type="STRING" id="387005.A0A183HMN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000874801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000874801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000874801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO57199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000874801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23363" checksum="981C791BB0CE1BDA" modified="2016-09-07" version="1">MVVPEKHVNSNSKRVIYHSTSPDEKALVKAAKNLNFIFHTRTPQCVYIEAMGKEEKYVILHVLEFTSNRKRMGVIVRCPNKKLKLYIKGADSVIFPRLTPDSDNLLIEKTTEHLMYFASNGLRTLCMAMCVLDDDEYEKWEPGYRRASFSFKDREKLIEEEAEKIEKNLKLLGATAIEDELQTVRKKKTLTSNFISLIESNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN04</accession>
    <name>A0A183HN04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010388">
        <property type="protein sequence ID" value="VDO57792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN04"/>
    <dbReference type="STRING" id="387005.A0A183HN04"/>
    <dbReference type="WBParaSite" id="OFLC_0000886501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000886501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000886501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000886501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19367" checksum="695A339F9B2062EE" modified="2016-09-07" version="1">MRGRMGGKLANAFSLITAYLLNMFWCICFAIVVILCFVYYIFTFLCSSISFNDSDCLDFSLFQPFIQQISTDSLKLCGGDVQQFCALSWSAFAWYLVGLISCLIIIKGLEHFMICSAANYAHISSGLKYLELRELLLSSDGDLVKADVRTSDYRMRSRVGNISSSDYGPLNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNA3</accession>
    <name>A0A183HNA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8964</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010562">
        <property type="protein sequence ID" value="VDO58190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNA3"/>
    <dbReference type="STRING" id="387005.A0A183HNA3"/>
    <dbReference type="WBParaSite" id="OFLC_0000896401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000896401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000896401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900075">
        <property type="term" value="P:positive regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052480">
        <property type="entry name" value="RAPsyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574:SF1">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000896401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18212" checksum="4CD2A6ACD823A08F" modified="2016-09-07" version="1">YSYFVFILYIIVVALSQLGFSQFQASLEAFEKAMCVANQYSDKLLELQVYIGLGVLFTLLRDFSKAILFLRSALAILDGVAVNDVHAKYRSVVLYHLSVVLRKSGSLIDAKATCDEAMKLAQETSNRSVYARCLCSIANIYCELGESQAKETLTVYFMNCNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP72</accession>
    <name>A0A183HP72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2281 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011234">
        <property type="protein sequence ID" value="VDO59537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP72"/>
    <dbReference type="STRING" id="387005.A0A183HP72"/>
    <dbReference type="WBParaSite" id="OFLC_0000928301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000928301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000928301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000928301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13222" checksum="4C536CEC3F7B7AF0" modified="2016-09-07" version="1">MQKDETILEDFEQEMESFLTEIREKKIQLPRRIKRKDHQDEPRIKGRYIELFPATNIPHPIKTVTFRTVSGAPTRLTSVPRPLYSSFAEGNIFVTYYKFFIRRSISVKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPK2</accession>
    <name>A0A183HPK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC2_membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9417</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011515">
        <property type="protein sequence ID" value="VDO60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPK2"/>
    <dbReference type="STRING" id="387005.A0A183HPK2"/>
    <dbReference type="WBParaSite" id="OFLC_0000941301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000941301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000941301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF131">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO60430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000941301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14916" checksum="C875B1DE7E691D78" modified="2016-09-07" version="1">MGLFLGTLYLQTEMNQDGISNIKGALFYYISELTYSTVFGIQTFLPSDFPLLVREYHDGIYPVICYYLSKIMSYLPIFTIDGICMVGISYYLIGLYPTFTTFLTTLVICILIEWSASSVGIMLSSVNKAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQQ4</accession>
    <name>A0A183HQQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9815</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012469">
        <property type="protein sequence ID" value="VDO63595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQQ4"/>
    <dbReference type="STRING" id="387005.A0A183HQQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000981501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000981501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000981501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO63595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000981501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="13130" checksum="ACD4F3EF48D7D780" modified="2016-09-07" version="1">MKASITIQRYLRGWLARTFYQKIKYDKTLREREAKVIIIQKFIRGWLARTFYHRLLHEHNVRKRENASVIIQKHVRFWLAQKTKIRNDRILQKRENAACILQVNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR61</accession>
    <name>A0A183HR61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DZANK-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9978</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012819">
        <property type="protein sequence ID" value="VDO64891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR61"/>
    <dbReference type="STRING" id="387005.A0A183HR61"/>
    <dbReference type="WBParaSite" id="OFLC_0000997201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000997201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000997201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 35-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="9">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000997201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17106" checksum="BE453A9C6EE3D7CB" modified="2016-09-07" version="1">MMTALHLTDYEDLIEPAEIYSLLALSSCLARQFAVCSRAFIKLECLDSFTADEREIYKKLAIKIFTKYLPKDTRMNRVECSACYAQIEDYCQVCPLCDTKFPTCVVTGRPLLEHQFWLCPTCKHRAYEQEIKLLKFCPLCHGNISNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRW7</accession>
    <name>A0A183HRW7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7652 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10231</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013405">
        <property type="protein sequence ID" value="VDO66862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRW7"/>
    <dbReference type="STRING" id="387005.A0A183HRW7"/>
    <dbReference type="WBParaSite" id="OFLC_0001022801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001022801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001022801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056069">
        <property type="entry name" value="DUF7652"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24665">
        <property type="entry name" value="DUF7652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7652" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO66862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001022801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21159" checksum="563C0DA9FAADEF5E" modified="2016-09-07" version="1">MDCFDQTPIYDIPSADYLKARLCHKLNPANCSAASEIIVSSTLLVSGWMYMIPLGAVVLLLLFTLCFIIICCQIRRTLNPNKKEKSFAGIERRNDASAPLSQSNTKNTLIHGSQTDSGIFTLGSTPNTNKSNGQSAQSTQGFSTRTGMIADQWNSNVESFTYTNDPYLQECSTQYQISPPLHDNKYDGLIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTD3</accession>
    <name>A0A183HTD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10744</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014668">
        <property type="protein sequence ID" value="VDO70985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTD3"/>
    <dbReference type="STRING" id="387005.A0A183HTD3"/>
    <dbReference type="WBParaSite" id="OFLC_0001074501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001074501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001074501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001074501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4372" checksum="6CF584C7015D0C96" modified="2016-09-07" version="1">MCCIERWAEVESDDTSCSSRELSDSDETGFEGSKSAFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTK8</accession>
    <name>A0A183HTK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014871">
        <property type="protein sequence ID" value="VDO71589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTK8"/>
    <dbReference type="WBParaSite" id="OFLC_0001082001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001082001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001082001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001082001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29239" checksum="2215361125F4A5E1" modified="2016-09-07" version="1">MDDNLADYRRFCANRLKRLERCKKTKSFCNLDDEVPYPVTNTDSDLMLREPEIFALHGGCTFSRCSENVMFSSAKSERMPFCSRTSTYCSGSNVPLVTDTPRFGSTGISPMNIMSSMAETNPKNLPMAANSWLEKNQKSISINGDINNRHLSPFSYSAPYSSSTIASSSIASQPSILSTKNPESEMRTMITTVNNSNDYGDSNRRAQRNFDLLREKMVKFIMPHNFKYLLNFLVPTRIRMTDCRNFTRFINLENISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUH3</accession>
    <name>A0A183HUH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11134</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015684">
        <property type="protein sequence ID" value="VDO74147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUH3"/>
    <dbReference type="STRING" id="387005.A0A183HUH3"/>
    <dbReference type="WBParaSite" id="OFLC_0001113501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001113501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001113501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO74147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001113501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14377" checksum="CA893669A4A1D3C2" modified="2016-09-07" version="1">MKGINDVDLYTVKVEDLTWTNNFSLRITRNDYVQALVTFFTVEFSKCHKRTGFSTGPDCQYTHWKQTVFYLQDALTCKKNEEITGTFSVAPNARNERDLDFKISVRFHGDVCDVEEENTYTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUI6</accession>
    <name>A0A183HUI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wsv136</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11146</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015721">
        <property type="protein sequence ID" value="VDO74244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUI6"/>
    <dbReference type="STRING" id="387005.A0A183HUI6"/>
    <dbReference type="WBParaSite" id="OFLC_0001114801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001114801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001114801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001114801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13022" checksum="1C730BFDEA84E2B9" modified="2016-09-07" version="1">MGLSSGQLCLFAIKKEVSSLLQHGNLRSLSLTYNSFDSVENDDQLVRVERNNQNNNDDSITTVTTVADINMSKKREAFIIDDGSIHLVTNKVIVYIITIVFVWNLVQIWKFFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUJ3</accession>
    <name>A0A183HUJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015752">
        <property type="protein sequence ID" value="VDO74297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001115501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001115501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001115501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001115501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8437" checksum="310100CAEEEE80D5" modified="2016-09-07" version="1">MANPFYTAYTNTRKSKCIISWKSGAGRDISVLVEIFIDSWGSEHFCDREMLPFDCFETIRMNSANKGGTLQVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUP1</accession>
    <name>A0A183HUP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMS_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015892">
        <property type="protein sequence ID" value="VDO74725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUP1"/>
    <dbReference type="STRING" id="387005.A0A183HUP1"/>
    <dbReference type="WBParaSite" id="OFLC_0001120301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001120301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001120301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001120301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9982" checksum="512F94F800262495" modified="2016-09-07" version="1">FQSITETASTWRKRRGGGVTATTAPTIPPTSVPSTSYQQQLLTRSVDKIFEEAELSGVLLLAGRKLKEFPAHLALKYELSDIISAGMSKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVS9</accession>
    <name>A0A183HVS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11592</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016920">
        <property type="protein sequence ID" value="VDO77623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVS9"/>
    <dbReference type="STRING" id="387005.A0A183HVS9"/>
    <dbReference type="WBParaSite" id="OFLC_0001159101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001159101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001159101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001159101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15338" checksum="3424BAF494F3D478" modified="2016-09-07" version="1">MRRQSLLDALANPMQRLTRYRLLLKTILKNTVGVTKRDTIQKMILQTEIAARDVEKTLAKNDLQNKLIEILKTIENYEVIDCKEFEKVCNNLTSFFFLFTESITYEITSFQSSIFRLQHLHFYTIINYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVW5</accession>
    <name>A0A183HVW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11633</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017053">
        <property type="protein sequence ID" value="VDO77997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVW5"/>
    <dbReference type="STRING" id="387005.A0A183HVW5"/>
    <dbReference type="WBParaSite" id="OFLC_0001162701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001162701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001162701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO77997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001162701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16692" checksum="0A97434AE0360078" modified="2016-09-07" version="1">MERCVGGSLDNHLQHWADKITTGERIFYGLEAAKGICYLHENDLIHRDLATRNCLISKYGTIKISDFGLSQLASDVTPVSTKQKIPLRWMAPETIQREPHYSVKSDVWSYGVLLFEIFNNGMKPWPDMDVRQCATNIRHGIMPDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVZ9</accession>
    <name>A0A183HVZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11664</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017138">
        <property type="protein sequence ID" value="VDO78274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVZ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001166101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001166101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001166101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001166101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11236" checksum="F9A9D5B0BF9D8708" modified="2016-09-07" version="1">MMLIPLHSSNFDVLTHIMDPDASSSRKLVESSWSPSQSPPPGMRSPLMSPKRSSSTSLMDEYIECMERPISTNDNRNYMSCFSHVVRNTEVYASYYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWF0</accession>
    <name>A0A183HWF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11817</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017583">
        <property type="protein sequence ID" value="VDO79481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWF0"/>
    <dbReference type="WBParaSite" id="OFLC_0001181201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001181201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001181201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO79481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001181201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14791" checksum="2CE6932C19B8B9D6" modified="2016-09-07" version="1">MWGFRCENKCHCRNNIPCDFATGFCSNAQCAEGWMGVNCFEDVNECITERHNCSSKATCINEIGSYRCKCSELYEGDGFSCKRMSFVFPLNESKISVGFVNLIFEQFLEYFDVSNTLYFLIVYIYCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWG0</accession>
    <name>A0A183HWG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11822</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017594">
        <property type="protein sequence ID" value="VDO79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWG0"/>
    <dbReference type="STRING" id="387005.A0A183HWG0"/>
    <dbReference type="WBParaSite" id="OFLC_0001182201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001182201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001182201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001182201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="7736" checksum="C84955B89F5E3099" modified="2016-09-07" version="1">MRRSGGAISKTNGGNHERETFSSPQVGIDLQSHQVKCRIGSASSPLNALLASEKSAEGNAVNRSGGNSAATAAATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWI8</accession>
    <name>A0A183HWI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017654">
        <property type="protein sequence ID" value="VDO79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWI8"/>
    <dbReference type="WBParaSite" id="OFLC_0001185001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001185001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001185001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001185001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15763" checksum="7AAFB95553DA8EB2" modified="2016-09-07" version="1">MYILAALFIIIVSLNGAVIIWLYITAPADNKLFYELFDNSVKEEIFLTEIEKGLDCISDDDKELDPTIECDNTINRSVISRKWLKPLLIFWIVGHVITLFLFGFINKGLFFFFFFFKLRINWGRIQKLFAHQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWL5</accession>
    <name>A0A183HWL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017744">
        <property type="protein sequence ID" value="VDO80081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWL5"/>
    <dbReference type="WBParaSite" id="OFLC_0001187701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001187701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001187701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001187701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="5469" checksum="FC08C52F98000B58" modified="2016-09-07" version="1">MIFRYPLGKIILHFFHYCYSSRILKYFRVWMIHATRIVLSFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXF6</accession>
    <name>A0A183HXF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ING domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018531">
        <property type="protein sequence ID" value="VDO82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXF6"/>
    <dbReference type="STRING" id="387005.A0A183HXF6"/>
    <dbReference type="WBParaSite" id="OFLC_0001216801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001216801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001216801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001216801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11172" checksum="6D9AAFB813022299" modified="2016-09-07" version="1">MLVEAADVPLEMILAKGDLRRLNEQIEKTTSALLQLTVPLYQKEHEDYLEAIRKSQHEQKAIVESAIERQRQALKEGDTNADDVLVSPNISSTTEINLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXT4</accession>
    <name>A0A183HXT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018907">
        <property type="protein sequence ID" value="VDO83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXT4"/>
    <dbReference type="WBParaSite" id="OFLC_0001229701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001229701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001229701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001229701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9858" checksum="BBE053BD20371325" modified="2016-09-07" version="1">MLQHCSSTVKETIKRQLNNSVQIRYGTRSLVPTSFQITLVSYAATNPPPPTSHVQTSLSNAHKQLPTVTAAFLQYDCSKPVKKTRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYB6</accession>
    <name>A0A183HYB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039852">
        <property type="protein sequence ID" value="VDP11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYB6"/>
    <dbReference type="WBParaSite" id="OFLC_0001247901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001247901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001247901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001247901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8040" checksum="304EAE0E2BB0A811" modified="2016-09-07" version="1">MQLPNGHKIAQKRPKNGNARVWITETIIAAKMNAPCCMHTSKSSSSRTIGSGSPYLGGLAFGSYLESHNIIHTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYH3</accession>
    <name>A0A183HYH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS12535</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039861">
        <property type="protein sequence ID" value="VDP11536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYH3"/>
    <dbReference type="STRING" id="387005.A0A183HYH3"/>
    <dbReference type="WBParaSite" id="OFLC_0001253601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001253601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001253601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="9">
        <location>
            <begin position="347"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP11536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001253601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54240" checksum="BF6DB8CA81E4D59F" modified="2016-09-07" version="1">MEPPAETSCSQQLSSINSDNNANSLDEKVRHTMERGASAAPPTTYQLQIDPNITFNSVNRPFEELPENFLESISPQQNQGSAPQESPQLASLAPMSLGSNDNFGKSSDFNAYATLAPMSATPSYVGAMKIEPLQDQLHSTSMQHSSHSAGSGPAGLLSPLQTTTRSDNLVCSSLLGVHQNGGRANEMLAGLRRHHPYIKEEVDLGQDFKTINSPFISHQSQQSASLLSQDDHQQELDHRLANAETPPAVSNVELASSFIATMIGEQPPSSPTPQHTIFRQSRHNFSSVDTAELHSSEDLEVNTEETSGDDLTFTDDNGEPTSTTRLTSTVGAPRATYSTKDATDPLNAEIDDDIYIDTTDLCKRIAWELKQHSIPQAIFAERILCRSQGTLSDLLRNPKPWNKLKSGRETFRRMFNWVQQPLELRLGILDMYKGKGGILPSSMSPPTPAQNARQGSRHKGRDGDGLVSTKRPRLVFTDIQKRTLQVMCALMISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0B0</accession>
    <name>A0A183I0B0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS13172</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01040072">
        <property type="protein sequence ID" value="VDP13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0B0"/>
    <dbReference type="STRING" id="387005.A0A183I0B0"/>
    <dbReference type="WBParaSite" id="OFLC_0001317301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001317301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001317301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF175">
        <property type="entry name" value="NAD(P)H OXIDASE (H2O2-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="570"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001317301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1103" mass="126685" checksum="C8ACF804D3D3D5C5" modified="2016-09-07" version="1">MLADEKAVPPYEKYQPHVPPGISHAFATAAFRFPHTIIPPALLFRKRANGKCEFRDEIGGYPALRLCQNWWNAQDIVQEYSVDEIVLGMASQIAENEDFIIVEDLRDFVFGPMHFTRLDVVSSSIMRGRDNGLPPYNELRQSYNLPVKDWTTINPVMYKERPEMFDELEKLYDGDISKLDAYVGGMLETNTEGPGELFKTIILDQFLRLRDGDRFWFENIWNGMFTEEEIEKIHSITLRDIIRQTTFIDEHELQENVFVWQAGDPCGQPFQVNSSGLEQCIPFMRFDHFTGNEVTFIFSCIALCVIPLICIGIGYMLIQKRKKMGGDMELCFKKVFLENTDLGHAKTEIAKKNNEKEKLHLSAIEWINKNYCRSVILIVDVTPLIRLEKPSGDLLRCLDLSDVNFINVAVSYPNSCTNPFVMISLPKHYDLVIRLNSEYQCAQFLHVLSNILNRTGKQLIIRRCPNSYIVETAETSERRQEKLDHFFREAYAKSFNIPQLSGDSSVVTCGSISEEVLGMTVTKAEMAEALGMRENDLFVERMFACMAKKDPNHVTFLKFLDVIVRFAKGSLHDKLGLLFDMCDREGQGKVHKKEFCDFVKSLNVTAGVKIEESVQDGIINRVLQRSGISVDSEFLSYKDFEAIFSNVDDVRHPLGVHMRGAKLKINLDETESMNSFAIRNEETGCTYISWYLWIISYLETYRQHIVIIFLFTAINLLLFFERFWHYRYETEHRDLRRVMGVGIAITRGAAASLSFCLGLVLPTVCQNIITLLRETPLREYLPFDSAITFHKIVGIVAGFWAAVHSVGHCVNFYHVATQSQDGLQCLFQEAVFGSNFLPSISYWLYGTITGITGILLVAIMSIIYVFSTPAVMKEAYHAFKITHLLTILLYALTVLHGLPKLLDSPKFLYYVAGPISLFVIDRIIGMRQQYKRLQILSGTILPSGMLFRKFANLTGILCIMEGELGVVYFIWVCSTHKNYEWFIEVLQNVEALDKENLLEMHIFVTQFFHKFDLRTTMLYICEKHFRSDSNGRSMFTGLHAVNHFGRPNFEALFKFVQNKHRNIREIGIFSCGPNSINKEIGRACREANKIRSAASFYHRFETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Y7</accession>
    <name>A0A183I0Y7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13399</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040180">
        <property type="protein sequence ID" value="VDP13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Y7"/>
    <dbReference type="STRING" id="387005.A0A183I0Y7"/>
    <dbReference type="WBParaSite" id="OFLC_0001340001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001340001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001340001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019520">
        <property type="entry name" value="Ribosomal_mS23_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001340001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15973" checksum="BA2C210C421A64C0" modified="2016-09-07" version="1">MREKCFNFYFRVTGLLRSGQMKWKERPLWYDVYVANPPQTELSADASLPIRKLYYKEDIAMARFYKQFRSVGAISISNEESESLCKKFIDLYKTIEEKWPELSEDEHYKKTLMVLNKKLSLQKRRISVQKPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I174</accession>
    <name>A0A183I174_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13486</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="UZAJ01040225">
        <property type="protein sequence ID" value="VDP13881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I174"/>
    <dbReference type="STRING" id="387005.A0A183I174"/>
    <dbReference type="WBParaSite" id="OFLC_0001348701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001348701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001348701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF29">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP13881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001348701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32464" checksum="0D7128B0BA21F444" modified="2016-09-07" version="1">MLMEPNDQGIMEFIFGSKFEFEPARKWASEMEWTILNISLTYVVTIFAIKYAMRDRKPYDLQQPLVIWNALLAVFSILGVAKITPVFLKQIATKGYISTFTEIGPCFTDDVAGYWTFLWIISKVPELLDTIFIVLRKRPLMLMHWYHHALTGYFAIVTYANKNAYMIWVVWLNFIVHSFMYSYYMLRSLRIRVPPQIAQFITFGQIIQFAITHVVMIHLAILVSTTTNNYAVTLRGFALGTLMEVTYLVLWIRFYYVSYYANGGKKYIEHKKNIKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4W9</accession>
    <name>A0A183I4W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14781</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041188">
        <property type="protein sequence ID" value="VDP18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4W9"/>
    <dbReference type="STRING" id="387005.A0A183I4W9"/>
    <dbReference type="WBParaSite" id="OFLC_0001479201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001479201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001479201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001479201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12519" checksum="A90615D4D3DF646C" modified="2016-09-07" version="1">MVRRRMASPKPSPPVHRRTSSPMSARSSPSVPMQTRQPAAPSAAPPAQFGMAPPSRGPGLMGQMAATAGGVAIGSAVIFQLQEVPTLDLTIVFTETQNDLSLCQSFNEIFKDCRAKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5G4</accession>
    <name>A0A183I5G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14976</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041435">
        <property type="protein sequence ID" value="VDP19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5G4"/>
    <dbReference type="STRING" id="387005.A0A183I5G4"/>
    <dbReference type="WBParaSite" id="OFLC_0001498701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001498701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001498701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001498701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16448" checksum="3FB08D4514B18802" modified="2016-09-07" version="1">MATVVEMTIEKIDEVKSRLGRSLGTPMRLRDLIRQVRAARTMAEERAVVDRESLALCTLGSICSSEMCRDLAGEVERLIKSSNTYIKKKAALCAFRIVKKVPELMEMFISCTKSLISEKNHGVLIGGITLVTEMCEKSPDVLNHFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I686</accession>
    <name>A0A183I686_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041826">
        <property type="protein sequence ID" value="VDP20999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I686"/>
    <dbReference type="STRING" id="387005.A0A183I686"/>
    <dbReference type="WBParaSite" id="OFLC_0001525901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001525901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001525901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001525901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18427" checksum="712CA90246980A2D" modified="2016-09-07" version="1">MDDQDERTFLCSYQRTRGYGSLSNPHVPTKAYRTIIQHQIGPNDTLQGLVLKYNTSIPIYDEIIEEDCISDRSINVKDNRGESIKSQDIDGESLQDIFKRIDMNIRKTTNSVHKLTENSTAGLLTEGFQMEFMQSKPEGKINNRCSLSRHSSGYQNEAYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6P2</accession>
    <name>A0A183I6P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042077">
        <property type="protein sequence ID" value="VDP21716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001541501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001541501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001541501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035161">
        <property type="entry name" value="DUF5332"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38612:SF2">
        <property type="entry name" value="PROTEIN DCT-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38612">
        <property type="entry name" value="PROTEIN DCT-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17266">
        <property type="entry name" value="DUF5332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001541501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13315" checksum="54929CC0CD0159C6" modified="2016-09-07" version="1">MKCPKMETCMEKCFHENTFRXXXLFADMKCPKMETCMEKCFHENTFRIGPCAKERCNAHCFDDECSHCIYLAKRIFLKICRENNIPALSNVNFNGKCIDLINNVLKEVASNRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6R5</accession>
    <name>A0A183I6R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15427</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042122">
        <property type="protein sequence ID" value="VDP21830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6R5"/>
    <dbReference type="WBParaSite" id="OFLC_0001543801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001543801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001543801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001543801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8956" checksum="6E1D8B44A903FF8F" modified="2016-09-07" version="1">MRNEEDGMSPSERWGQAINHYQEMMNNRDQCCTSPPNSPVNLGTSQKFSFCGTSSSACDSPSADVDNTHILGSLNGSLMGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6U1</accession>
    <name>A0A183I6U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042170">
        <property type="protein sequence ID" value="VDP21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6U1"/>
    <dbReference type="STRING" id="387005.A0A183I6U1"/>
    <dbReference type="WBParaSite" id="OFLC_0001546401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001546401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001546401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039320">
        <property type="entry name" value="RNF207"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001546401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42341" checksum="EECD1CE71F4085C7" modified="2016-09-07" version="1">MTDTLLTVRDRLLKKLDEEMDIRIQHFREQMRQLTSLQPTIRLCLLSASIFCSSASKLDFLQCYTDLLKRIQSLISMQCEKPQYTGELTVNSREEFNRALEPFLGLSSFLLCTSVSNGSDGNERNCGAISPKNSFVKRSGSSVVNGCQLLLSKYQLVVDLAGAFGEQFTKVETPLQQYNHEMTKLGKKVQELQRDLTLRRCIIEKDSMTDLIHRVGQHSAVVSDLQPQLQQIWQEELDRVRRQQVLFREKIEEIITLREKACHIVNAAKQFKPYAVCLAAVTSVIDHKRCHKPDPAPMETICQQINTLEPDSQQRIEAIEKEEQNRRLVQDQKRREEQMKIAAVKKSLKTTKEQKRLMKKSTDGKCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I750</accession>
    <name>A0A183I750_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15562</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042369">
        <property type="protein sequence ID" value="VDP22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I750"/>
    <dbReference type="STRING" id="387005.A0A183I750"/>
    <dbReference type="WBParaSite" id="OFLC_0001557501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001557501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001557501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001557501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9265" checksum="97C63F86276DB4F6" modified="2016-09-07" version="1">MCTDNGLISSVHFRNFHKLCRRGTLEFPLRKLMLGEQIRQGFSPLIAVLTTDAVERIAAKNNLSFTDLLLPFATVNCTLKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I759</accession>
    <name>A0A183I759_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042383">
        <property type="protein sequence ID" value="VDP22641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I759"/>
    <dbReference type="STRING" id="387005.A0A183I759"/>
    <dbReference type="WBParaSite" id="OFLC_0001558401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001558401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001558401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001558401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="26966" checksum="419E83F4807A3332" modified="2016-09-07" version="1">MEVCNRSGRTATHSQLLQHRNAATASQSSAPAATLGASAPIITAPVAAAAPQNVASAISQNNILAARQAPFASFMNPHAAAAAAAAGTLVPQLVSIPFVDGPMLATQAIPPVSAAWTQAATASLMPWALPNTTALFANEFILPAHLQTTRNVAALAAAVAAGTPFSHLLAPQIKSYPDLANTDPAALFWNDLVQQQQIRGRQAPTASANPNGTLTTSTNLSNLRMRSGPSGLAKDPAIIAAGPRMNSTASGLETPKYQLETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7M0</accession>
    <name>A0A183I7M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Wsv094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042733">
        <property type="protein sequence ID" value="VDP23524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7M0"/>
    <dbReference type="WBParaSite" id="OFLC_0001574501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001574501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001574501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001574501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="7040" checksum="C613BEDBAEE899D4" modified="2016-09-07" version="1">MMMMMMMVMMMIMMMIIMMIMMMIMMTMMMMMMMIMMMIMMMIIVMMVMMMMMIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8N7</accession>
    <name>A0A183I8N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01044080">
        <property type="protein sequence ID" value="VDP27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8N7"/>
    <dbReference type="STRING" id="387005.A0A183I8N7"/>
    <dbReference type="WBParaSite" id="OFLC_0001611201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001611201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001611201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001611201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11358" checksum="6607FE97E64C1453" modified="2016-09-07" version="1">MQKIIDEIDNMAANWDSTKKGSMKLPGQDIQVNDVEMFQKLLHLNDFRNFLINDTNFRCRQCPLFREHLLRRLNYIDDSNLVSLKGRVACEIHHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VS71</accession>
    <name>A0A3P7VS71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002705">
        <property type="protein sequence ID" value="VDO37927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VS71"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="159" mass="17962" checksum="1049219A2252E617" modified="2019-02-13" version="1">MLRRDVSFLNKYFSQKFLQSCGPDTVNELHKGLEQLQNWASISCFGYRTLIDTYKKHLLIIGDKNEEHLITKPSSAVPGYCRSKCCSIRDDYTEQNGIIHQINSIPAQQLPTVTAMNLIEKAFTPPRENSKIDDGYAGLDSCSVVSNATIVEREQCNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WP54</accession>
    <name>A0A3P7WP54_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS7091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007157">
        <property type="protein sequence ID" value="VDO49274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WP54"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO49274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="122" mass="14045" checksum="3AA7AC71EBDA89A9" modified="2019-02-13" version="1">MQCTWTRHGGIRVYARTCCTNDTSLCRDAAEQNRGILVLLNGLCSTICILLISVVVRERRRHHEVRGWALMEIFFLGASMLYAILLLDWFNSVTSTCCIAVWLRQIGFSTFYGSIVLKIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XI64</accession>
    <name>A0A3P7XI64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000666">
        <property type="protein sequence ID" value="VDO29498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XI64"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="792" mass="88389" checksum="D9280A2D5318EE15" modified="2019-02-13" version="1">MKCVVTATSSTQASVNLGRRRHPLINLHSRQHSGQSNQMQSSARAFLAPSAPTFHGPGIVGQVIVRTNGPANAEAASRALDAAMQAATAAVGENGVHVQINGMPRFIPSMSRSRSNVMWARRTYTNRGDREGGPEHPNDMFIGPHYPNDSTIYTNDPHLNCQSNLCNPRANIHNSAAYETLISDLYQATLRYKENLDPQSSEIADVEALIRRWDRVRGLHDSDAHVALNQRGEALFERPEHFKNVLMAMLRRAVANLADADADIAHRLSASQGEYDISNYGMVPVISTPLHGFEIPGPPIGSIELDAVDIEAFDPSQEVQMRDESLGEDTQTSHNDTTQESISSETQASSTVEPTVEDNTNESDLNIIEMIRTLSDLMQSGRSTTLAQVMREIGQPVTRLDTGFVNLVMVLAYEILQIPEVVQILNGNFSSLSKNRHQMRRFLIQNVFNDNCRPSDEDLKNAAERVALAEEKLDRFLAYSDVHRYADVDGVGRVDLVASVLRLEKRIVEEFLRHLMRTDDDLTPEEYSKTIVDLFTAYVYRAVLLTNLSMKGQPYDYESLLLRFMERPARVTEQHLSVSMAQMSMSHIRLLLRRETPFTVHDMMEDIVLANEHDQSIESNSLPASNESEYVLTNSTSKCDDASDKGKNDKDKKSDDIEMQDAQASVADGTWMSILPKDWISVIQDDKNRSISRNVKSFSDAYLGGCSTKRKGMKVITEGSCDGMVSSAVKRSLEEAVSCSGFAPANIPTPAETANVLQNEFDDLVRQRVAQDEKFDPEKYPELNKFLKKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XJ17</accession>
    <name>A0A3P7XJ17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011279">
        <property type="protein sequence ID" value="VDO59637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XJ17"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="161" mass="17861" checksum="0ACED53C15186AAE" modified="2019-02-13" version="1">MRIIKHYFQEEVIVHSGSTSPPIRPHFVTPEANTQFSKPFPSAEFDICNRDRAACDEPLLSQQFLCTQTAQICKTNYARDAEELTHISPSHLFYAQQQLQRSPFVGSQSSQISHQLASVRMPMMMTITGSLVPSPNSAFSPPVPSSSLRSVIEAPSPLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XPU7</accession>
    <name>A0A3P7XPU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001105">
        <property type="protein sequence ID" value="VDO31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H3J2"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="184" mass="21385" checksum="3C6B4B40B7CE0643" modified="2026-01-28" version="1">MNLRVAKADDLLNTQHCNLLCLPENYQMKYYFYHALSWPQLSYVAEDDKGNIVGYVLAKMEEEADDEPHGHITSLAVKRSYRRLGLAQKLMDQTARAMVETFNARYVSLHVRVSNRAALNLYQNTLKFEISDVEPKYYADGEDAYAMKRPLVQFAVENNIEPADRKAFFSTKEEREHARKQKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AKS2</accession>
    <name>A0A3P8AKS2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type III domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040487">
        <property type="protein sequence ID" value="VDP15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AKS2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="215"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="332"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55360" checksum="40C5C1B76DD8BD9E" modified="2019-02-13" version="1">MVTGVKCSNLLRLEPPPLNNSRYVVRVDRKFRISCICQQTSINCMHLTWRNEFGRKIDGESSNSLFTIKLREHDSMYKKLSLVFTQIAKRDTGFYRCVARNSRRMSADWKVELIVVDEIHWKENNDIVGGMLGESLTIDCGSTGNPQPETHITNHKGLPLNETLFVTAGSEVTIKKLTNEYQDTIIKCLSVQEFEQYDATVVEEHEIRLDVWSSPKFSKSFVERFIVLDHLAQICCNVTRSNPPATHFRYLRGSNEIFNDSNHVVLTDALNQSSCLKILSPTEYDLGEYRCEVSNQKSKSQQTIAVKVAKCSDDLCDLESVHFCAKSSVIAPPGEVHVSLQSVGMTYVIWKIEEGFGEQLPIRRYIIEYIKKSILDQDSHDRTRGNNRVWFTYAIKMDVHLSKDGLYEVGGLRQGTMYLFRFAAENEAGIGDTVTVAVKTTSKIKLSKLTRSSSSHFQQLTFYRFFSLLFSHMVILKSSKFANFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AS73</accession>
    <name>A0A3P8AS73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013554">
        <property type="protein sequence ID" value="VDO67358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AS73"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="117" mass="13850" checksum="2F291CDD37B2FAAD" modified="2019-02-13" version="1">MKFKFEFFKLSFGKSLSCGINDPSSYNCKWSDTFVFIQDILTFISLALMSTVVSLRLFWFIPEVNYHRRNPIGQNYVEGQQINLPYFIKCDKQKGHSQKYKYDNNYNDNNPYQSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B4R0</accession>
    <name>A0A3P8B4R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039931">
        <property type="protein sequence ID" value="VDP12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZ73"/>
    <dbReference type="OrthoDB" id="3908708at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298:SF2">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="248" mass="28592" checksum="098B23411DAE7252" modified="2026-01-28" version="1">MLKYQLRSRKLCSKYQDKTIQSNNVNTLSHSSDKLSSSSSSLEETIHICDRSHSLNSLCSIDSSDASEWGTLRVYTADIKEDTDYKTLKISTNHTVKNIVDTILTKFRLFKDPNLFEIIMEVWTRYNGEQVKTPLLLPQEARPLELQRCHPMHMSRFLITMSTNGVLVRIYDYLLSPKSTYKSMFISPRTTCYEVIVMLLVMDQQPGPPTDFRLYLSETDSDLNMNDTLADLYLVLSNDQKIIIRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BCB1</accession>
    <name>A0A3P8BCB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040470">
        <property type="protein sequence ID" value="VDP15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="131" mass="15659" checksum="61DF613FF8A5540F" modified="2026-01-28" version="1">MFVGTEFDPQYSAQIVITQQQCTDRRTLQRHIRGAFSHRIFRIGRVTAKWRPRHEDHGLSAFLSFFPYFLRSNRCFFTTTMFCLEKVRQMPQYPSIHHIASSHPRGEDIPPLLQCSSQLVISKMRCRWRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYK3</accession>
    <name>A0A183GYK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERCC4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000092">
        <property type="protein sequence ID" value="VDO25346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000031201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000031201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000031201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000031201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29935" checksum="EE530D36CE18C1A6" modified="2016-09-07" version="1">MHNALDKRLSSREYILSITDDELSRFPVAFIESFYPDLSLGRPICVIGEIMQLEQRLCDLKTGISSSKQSSEPLSIESENFLKSYRSQITIHIDAGFQVSNKRSSQSGFDIRQLILSAQNRKIIPLDWEVVKQLQPFLSVIEFQNMAGKMGFHTFLQKQQLGLPLSNPTNSCTTSSYVQRAQALNRRRKLDLICEFLLHSGNKLNCSSCRNIYHPTREPSVPANNSLCSEDIVKQSANGKLSPVIKITDTETENVEIHESNSPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYY2</accession>
    <name>A0A183GYY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS442</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000145">
        <property type="protein sequence ID" value="VDO25809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000044101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000044101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000044101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="559"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000044101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="681" mass="76587" checksum="B57A6C66E477DB47" modified="2016-09-07" version="1">QNSGNPYYGVPIGAIHYSDGNTRAEAYAASEYTIIFHRFTHHPRQRGCTSMIIGPSRTADRNTVNGGVFLSISQPMVASQPITRRRFTRQVPFTVCGIRNCPVQFDHLELRKDGEETTLSQQRDPFAGIEIDMNSSESVTPKTKDIHIEEISGPEIIDLSAALITFVCFIFSTAVQHRILIIDKNRYDLNMNSNAINAAVVTTQDDFSSESMNEITLFDTNTTNIFDGSEISVKTQDDGGQLNPAIDSSIANVNTTSEVNSDNIKSTRSGTENFHVDIKFEDGDKVETAMHPNEVLKQVFVSIKKTAEGIEHDTKQGEKIRNEIKDVIKNGDSSEKFGNDIFLYRGNAYPLKQEDSQEKLMAHHKKKAEKSNKFEAEDKGFPIMLDSKNQKQYENSSGPPTVEKRIKDSFVSAGNDKSTTDDYILTNKFFEAEEAVVFVSTQNTEVTMTPLLGESTALYRVIQDPRLKKGKRMGFRKKNKHENNLDHRTVTTVTATEKVHIDRRFELPLVKDKTVAFSVRNGAKITEYQWIALRDHCAQRTIPLLSLKGINPPHEQEIGPVLGQSHNVTSLPVQILNCNTIFIPSFVFNQGDSPSETYFYAGIGHFPDRIEKQVRANVVGLPPDQPLRNYKGENVMIRLPKTYRTFDVDFISVFNEIEERSYGHVVTPSLLVPPCNDYDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0E3</accession>
    <name>A0A183H0E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G_like_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS953</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000394">
        <property type="protein sequence ID" value="VDO27704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0E3"/>
    <dbReference type="STRING" id="387005.A0A183H0E3"/>
    <dbReference type="WBParaSite" id="OFLC_0000095201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000095201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000095201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000095201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="29484" checksum="33E36D6263E73533" modified="2016-09-07" version="1">MLNAAQKSFSHNFAALARYHETLKELSDINDESSMALLRTLYSVWKHNRQMMVVLITKMLRMTLMSANAVVFWLLSNLDQELHRFWLWEALFIVIKHACGHTNRCKKKFQQMQEKRAKMDRNDGEANQNFCFKEEEDSLGVILDDDVEEKRKELKELQEMLKNLFLNVLHKLVVFLSEHLVKYETAGRNYDTYWYRYMMGRFKEILLKYWHELFEMKQDIDKELFVTAGIDSRILEVYCQFTALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0S2</accession>
    <name>A0A183H0S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1082</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000464">
        <property type="protein sequence ID" value="VDO28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0S2"/>
    <dbReference type="STRING" id="387005.A0A183H0S2"/>
    <dbReference type="WBParaSite" id="OFLC_0000108101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000108101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000108101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17301">
        <property type="entry name" value="PIPKc_PIP5KI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF101">
        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000108101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52706" checksum="A2E36AF430F2F3F5" modified="2016-09-07" version="1">SGSQSTPSHNYGDFRFQTYAPIAFRTFRDLFAIKTADFLRSVCMFPLKELSNAGASGSIFYVSHDDQFIIKTVQSKEAEFLKKLLPGYYMNFNQNPHTLLPKFFGLFCYQSLGKNIRLLLMNNLLPQTIMMHEKYDLKGSTYKRLASKHERAKASPTLKDLDFISEHPDGLLLDVGVYDAIMKTISRDCLVLESFKIMDYSLLVGIHNKNTGKNATDVIDGGEPSTSNQKTKSKTVRVKSEKLLDSDYYKTYEQISFPARNQRGDDLLLFLGIIDILQNYRLLKKLEHTWKSVLHDGDTISVHNPTFYAQRFITFLKSHVFHMTAAELAPKGSHTKFKSVVTSYLALRHSPSKRFLPRRSLTEKDEAESATLIDTSRRPFSNLQKPREKKIERLFAPDPDPTEILRTTKSHSSEENIMVSFLIHLIFYNFIILTKMDAILIEITRILCYIFSCMLAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V1</accession>
    <name>A0A183H0V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1111</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000477">
        <property type="protein sequence ID" value="VDO28290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V1"/>
    <dbReference type="STRING" id="387005.A0A183H0V1"/>
    <dbReference type="WBParaSite" id="OFLC_0000111001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24507" checksum="1DF151840DDF2968" modified="2016-09-07" version="1">MGTKIGLINEKIKQKKREMQRNIQQRILKCRFNYVHECELHNGTGEKWRDHDRLSIAHVDRINMHSRITNFSNRKRKCISNQKICNASTSKADTTQMGRRVSLETPLGFFQMLPRELLHNLFDRISVHQLVIISLTSSIFNSEVRHYLLLENASRKFSAETTTHMMKNVLDLDPFYVWEWQHYKLAWMGSLLHGGMFGIDLEKRMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H136</accession>
    <name>A0A183H136_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBM_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000528">
        <property type="protein sequence ID" value="VDO28622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H136"/>
    <dbReference type="WBParaSite" id="OFLC_0000119501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="20067" checksum="BC4E1FA3D2375E39" modified="2016-09-07" version="1">MISFFFIQYIFILQVLYLQANYSMRHMCAALLRTLRLLLILQLILCNSLCSSKKYRRYYQKHYHVTLSVRNHNVTEAKFFRLIGVGNTADFFVAPGDVFTKTYEARRKGFWTLFVEFPGNRYSKSPTKIISRDSHKHWVMEVYYYPGAVGFSDWYQVYDEMLKNNIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2K7</accession>
    <name>A0A183H2K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1717</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000863">
        <property type="protein sequence ID" value="VDO30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2K7"/>
    <dbReference type="WBParaSite" id="OFLC_0000171601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000171601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000171601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000171601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22199" checksum="628D96B34A184C69" modified="2016-09-07" version="1">MAEWSKALVLGTSLFGDVGSNPTLVKIFREFDFYRITLVFNELYNAEWKKLPRARWPSGLRRWFKAPVSSEALFMLKFNGTEGEVPHCILSNIRLVSIDRMSLFSLSVFSVPVFSCIFVRNSCEYRHRYHDTSLSTTFSITHCHPHSISTHINAAVPLVEMQKTLIARLSPALIYWEWIPPGYLGRRRQGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3P7</accession>
    <name>A0A183H3P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2107</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001145">
        <property type="protein sequence ID" value="VDO31893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3P7"/>
    <dbReference type="STRING" id="387005.A0A183H3P7"/>
    <dbReference type="WBParaSite" id="OFLC_0000210601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000210601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000210601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000210601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8486" checksum="7A7C9BD4DFFC15A4" modified="2016-09-07" version="1">RKERGDGFVRKVLGSFAEKTIGCEEEEARLIPGVAFEPSSPPTDEERMRAWEVGHPDYLGADAFDNIQKAIDHALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3V0</accession>
    <name>A0A183H3V0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2160</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01001183">
        <property type="protein sequence ID" value="VDO32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3V0"/>
    <dbReference type="STRING" id="387005.A0A183H3V0"/>
    <dbReference type="WBParaSite" id="OFLC_0000215901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000215901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000215901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH84" evidence="8">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000215901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79921" checksum="0C2CFF89ECD27459" modified="2016-09-07" version="1">MQTRSKTKAEKERRAAQFLCGIVEGFYGRPWTADQRKDLFARMRRLGMNTYIYAPKDDLKHRAEWRQLYNSDEVELLQSLIQTARMENVTFVYALSPGIDIIYSSEKDIKALHDKSEQVRCLGCDAFALLFDDIDVAMNDADKKQFPSIVMAQLTVANSLYEFLKCPHFFFCPTEYCESRANPSLEESDYLITLGPRVVSREITVEHIRRVAAVLQRKPVVWDNLHANDYDPKRVFLGPFAGRPVRLKEEIAGILLNPNCRYEANFLPFYTLAEWNSCHADADVLEGIATMLIFDHLEIVLVRYSFSEGLKAESDAILEAGDVVPVAAHIVENASPKRLYHPLKALDEGIKKWIEYFNAESSTNSHPSVSVEIAEADELNELKPSTGSISVVSRELNAPDNSDSQTAIIYFNAENSSVVQTVNSMCSEYSEPMDLMSVAKDDTKPLLEASDQNKGNVQEMLEVSSDISMDSSVHSDSETNITGVDQVAVFVDMFYLPFEHGRRGIQMLQEFSWLHENSYVMRRSSNSIDDQKVQEFVSDEWKRRCEDFVKLLRDVTRLYQHITQLPNRSVVQELFQYVYDAQGMTSILEALVLWMAGGHLNITPTDCDCFWRVGIPDVEPWTLSGGFLTDLQKLLYSNANLADLFLLKTMLPLFLNCYTVRPYADEDMKNVRYICKTEHEYVSNMGILEEIKNEFFFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4U5</accession>
    <name>A0A183H4U5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2503</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01001451">
        <property type="protein sequence ID" value="VDO33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4U5"/>
    <dbReference type="STRING" id="387005.A0A183H4U5"/>
    <dbReference type="WBParaSite" id="OFLC_0000250401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000250401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000250401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="10">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000250401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23808" checksum="9C3209D87302846E" modified="2016-09-07" version="1">MSSSSEPEKKRSRSDENGDEIEEEEIKELPKGWEKRMSRSNNRFYYFNVYTGRSQWERPAKPADPAQASLNEVHCAHLLVKHNGSRRPSSWRSDVITRSKEDARKILTGYRKQIEEASDKKSKMRDLAKEFSDCSSAKRGGDLGFFKRRQMQKSFEDAAFALGVIFITFETNFKIIVAVKFIFSNMKISAVLKYYILQLKHVMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4W9</accession>
    <name>A0A183H4W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2529</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001473">
        <property type="protein sequence ID" value="VDO33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4W9"/>
    <dbReference type="WBParaSite" id="OFLC_0000252801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000252801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000252801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000252801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20908" checksum="238231C606725A67" modified="2016-09-07" version="1">MKKFFLSLIKGSGELVQSEEMASTTTSTYENILRTLPGSFVRSKLFRIVMQIRKKMGIRKRRKRKKKDKNVMGNIIQSGKKGKGKKKKDIKKKDEKKKSQEPKYCCMQKIDKGQLQVLASSTSYDDKSTTPPQLTFIFNHTVIPSFDSVHTSMNNNIINRTNEVLSNITFEHIHQQMDHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H504</accession>
    <name>A0A183H504_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2566</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001500">
        <property type="protein sequence ID" value="VDO33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H504"/>
    <dbReference type="STRING" id="387005.A0A183H504"/>
    <dbReference type="WBParaSite" id="OFLC_0000256301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000256301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000256301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000256301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31002" checksum="D048D0AB8195B3FF" modified="2016-09-07" version="1">MGKDFSIEQFNSVTENLPFLELSMITKTIDAIKQRAQSMVHVEDQLLKLISCIDLTSLNSDDTDNVIEQLIDKAILPFLAVRYLSIMNLFEKPETRCAAVCAYPARVAGAKHYLHSKYDQQQPLAICSVAAGFPSGQYRIESKILEVKLAVEDGASEIDIVISRDAAVEHDWKRMYCVYDEVAALKTCCGSNCMKTILATGELQNEQNIYRASWAAMLAGNSNIITRLYIYDFTSWIRPRGTWSIQLVYKSRPLFACLASDAIDLYKLKCQHSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N5</accession>
    <name>A0A183H5N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2795</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001698">
        <property type="protein sequence ID" value="VDO34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N5"/>
    <dbReference type="STRING" id="387005.A0A183H5N5"/>
    <dbReference type="WBParaSite" id="OFLC_0000279401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="56"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27870" checksum="4EEC4ABB2EE45836" modified="2016-09-07" version="1">MPSELEKAQKPKKDMDLLHTRTGGAYIPPAKLKMMQEQISDKNSEVYQRLNWERLKKRIHGQVNKANTSNLLNVIRDLLQENVIRGRGLLARSIIQAQSYSPTFSNVYAAVVAVINSHFPNIGMLIIHRLLIQFKRCYKRNDKTSTITISKFIAHLINQQVIHEILALEMMILMLENPTDDSVEITVAFLKECGAKLSEISPRGLNAIFDRLRSILSDSDIDKRIQYMIEVIFHIRKDKFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Y8</accession>
    <name>A0A183H5Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2899</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001792">
        <property type="protein sequence ID" value="VDO34608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Y8"/>
    <dbReference type="STRING" id="387005.A0A183H5Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0000289801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000289801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000289801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000289801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26856" checksum="1DBF457B939B95C7" modified="2016-09-07" version="1">MILHSIVFPTARFARAVNSCRAGSRRLGHANKSCRKFVLYSCLLCFFILLPLRFDGTIELNYALVFLPLWICEFVVFLGAVIAAISFTISPPSSTESSLRSDFYGMILCTGEHGLLTLFGVLCCHKLQTNATIDELPWLLVFVPIFALSLLSVVVAIWAIRNDKSFELELFFSVNIVQFVFIAFKLDGILDWHWTIVFIPLWVVLSLSVVGVSLLIVFMKAMINRVTFTHLISLLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Z7</accession>
    <name>A0A183H5Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2908</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001800">
        <property type="protein sequence ID" value="VDO34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Z7"/>
    <dbReference type="WBParaSite" id="OFLC_0000290701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000290701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000290701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF193">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000290701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="14378" checksum="A6B10BBCED36D488" modified="2016-09-07" version="1">MKIASIEPQLRRFFQWYNEFGYRWRWFLVIAPLIITSFLSFGFCRLTVLIVDDSFYVFTPIYARWHQEFETFSSLWPLNENKFLRANLKDDGNLLRKQVLDEIQRLNQWIMFNKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H661</accession>
    <name>A0A183H661_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UNC80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2972</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001855">
        <property type="protein sequence ID" value="VDO34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H661"/>
    <dbReference type="STRING" id="387005.A0A183H661"/>
    <dbReference type="WBParaSite" id="OFLC_0000297101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000297101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000297101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 central region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000297101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58579" checksum="376393D8929A94BB" modified="2016-09-07" version="1">RRLAQGRQRLFKYGSPSNISSQPFESSERLRRSMKNLKSPKSTQFDDEKDGICEITAPAITTVGWGEGIRDGLKQSNETIVSPENGSKISLVMPVPPSTQDSISRPIVSSHQQLQTNFDEDEEMMFKNFPWLKVIIKMANSFNLSCNHERFCHPWCFERVYRQCYRLTEALRKVYGEDLPPLGHLDKRKAMTDAWLNRHENVKKAAQRHSGLHLTRRENTAVRQGTTPDKPPMALRNLLIEKLNEMEEKERMGKSNFHDSDDLIEIMQIQKRPPPSPMLSYITTHMLCIAHAPFSTLLKSCLVLRSEHYRETMDICWHLLIHRDKHIVTSAASLFIISSVRNPEGTVNVIKNSLSSDDPNIRTEGLRRFHALWRNRFHVWLKMEDGAQLVFKVPPPGIDFTLPSPPVGQSHISIVDPPWMPHIKTKVEELCLKEEEQTSQTIMTMTRTRRKQKQEMIRRAAQEASERESSLRQKFPFRATAIVQQAAYEPALFHHQTQVMVDNAGEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6G1</accession>
    <name>A0A183H6G1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3072</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001937">
        <property type="protein sequence ID" value="VDO35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6G1"/>
    <dbReference type="STRING" id="387005.A0A183H6G1"/>
    <dbReference type="WBParaSite" id="OFLC_0000307101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000307101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000307101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000307101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13067" checksum="AEEC9A47EBB846B1" modified="2016-09-07" version="1">MDSIYRSEEMCLAQLFLQTEAAYACVAELGELGLVQFRDLNPDVSAFQRKFVNEVRRCDEMERKLRFLEREIKKDLIPMLDTGENPDAPQPKEMIDLEVSCKIKNKQIYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6S3</accession>
    <name>A0A183H6S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3185</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002052">
        <property type="protein sequence ID" value="VDO35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6S3"/>
    <dbReference type="STRING" id="387005.A0A183H6S3"/>
    <dbReference type="WBParaSite" id="OFLC_0000318401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000318401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000318401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF7">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000318401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30867" checksum="34C9810C2FF76BC1" modified="2016-09-07" version="1">MFTYLFRHYNAIATQALEYEYPFPNCIYTIRKDEIDGPILKYARVGDQIVHRWECLSDVYGLLVYNCYVEDGQGEKQIVIDENGCHTDRTILGDPTYVESLNMAYRDSLVFKFADRVIVRFQCQIRLCVKDGGGCVGITPPMCFGEKQQRNDLFVTTDESMLAHAPKMSNITDIQSKKRRRIRSSVSERSKFTVDADLISQPVYVLDTDDEDADEYNNRLRQNMPEVCVSNALFVILICVMIVALLALTASSIWLMRRWLRLVPKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H712</accession>
    <name>A0A183H712_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kaptin (actin binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3274</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002140">
        <property type="protein sequence ID" value="VDO35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H712"/>
    <dbReference type="STRING" id="387005.A0A183H712"/>
    <dbReference type="WBParaSite" id="OFLC_0000327301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000327301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000327301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000327301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45324" checksum="46E2307142B502A4" modified="2016-09-07" version="1">MFLPDGSEHKLRLPGCHENQEPHVSCVVGNRDKTLFVAVISSIFYVYLAHLKFFFQFQPQLLLCSFRRSEEDVEEKGEYRKVYWRHDSSAICFTTSKNCLLLYRLDISSDKQSFSLTEPREEHLRRTSQELFIHEKSPKTAVYLSIVARLESPATCIVPFRDDLSVCLQDGWLHRISWEGVVDKNFSFHLFDVPFVVDQLQSKTEHVQELGAHVVDMAYAPLIGGFCIVLSNGNAALLTSSSSRFLPKELLGIWAVQLSDAVCTAANHKCRLVVYGCRKCDFDICFDFFQIILAVFSGDIAAFHLDDVNGTLTLTFRVTLQVKNGPELLNRMGQVRHVECYTEGTALAVVWSPLLCDSGYANSLNTVPIVAIFSSFGAQLWCSLESSSDRFLFILKLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H741</accession>
    <name>A0A183H741_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3303</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002170">
        <property type="protein sequence ID" value="VDO36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H741"/>
    <dbReference type="STRING" id="387005.A0A183H741"/>
    <dbReference type="WBParaSite" id="OFLC_0000330201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000330201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000330201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000330201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11965" checksum="0CB10AC5C2D23114" modified="2016-09-07" version="1">MCCIAGKIKLSQLEEPSEPLLAGYTAESKRFLSKIRKCKSVLPIDFIRRRKCMLRNSYRHRKNVNDGNTTNVGRLTILPSSSADSPRHMHEYAQDQLHMFATTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7B0</accession>
    <name>A0A183H7B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Olfactomedin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3372</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002231">
        <property type="protein sequence ID" value="VDO36271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7B0"/>
    <dbReference type="STRING" id="387005.A0A183H7B0"/>
    <dbReference type="WBParaSite" id="OFLC_0000337101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000337101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000337101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF85">
        <property type="entry name" value="GLIOMEDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="6">
        <location>
            <begin position="252"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="253"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO36271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000337101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52886" checksum="0E9BD264D2D6AC16" modified="2016-09-07" version="1">MSDEERDLKKIRYLEYCQAIYLLLTLLVFADVYSRIGDVETNCRLEKERMISKRVRRAIASSPSIQTSLNASEHEVSIHSLSKIKGNELLAKCLEIHQYCAKESGIDRGLPGPIGPPGLPGSPGKPGPPGRDGLMGMPGPPGPQGPPGMPGKPGICPKCPVAENFEMFRTECPKIEPMECPTQMTFEGEGGLRYVEHQLPYFVKMMLLNDSDLTTEIDKCVRFCLSNVTVPSETVIVPVSTEIPYIEGATAHCYLEDVGKPIFHAHSNTYFGAWMRDAYPQNGKDMMKRWLTKHFQGDTVEEYLDEGDMRRQRVFVTHHLPYLYDGTNLIFFNGSLYFHRAGTPKIGKYELRSKKYDEVIIHKHAAHKGNNYLFNLSMNYFDLAVDENALWVLFHYENEKFLSVAKLDISNLTIYETWNLTLINHAEVANGFVVCGVLYLVSLNFKNEKYMNTAIFDFSHLIESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8E4</accession>
    <name>A0A183H8E4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS3756</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002617">
        <property type="protein sequence ID" value="VDO37654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8E4"/>
    <dbReference type="STRING" id="387005.A0A183H8E4"/>
    <dbReference type="WBParaSite" id="OFLC_0000375501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000375501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000375501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="14">
        <location>
            <begin position="192"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO37654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000375501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61652" checksum="5F2122B245021B0A" modified="2016-09-07" version="1">GYFGNGAICIADPADCIHYPGLCHSNAICDQEKRRCKCTRGHIGNGMECSRKKDFLCLNNTNICDQNAECLSTGLCQCKHGFEGDGYYCFAAAMEFETLIETTKSSLSECKQQCVANEQCYHGECRCAEGYKRGPNATCMDIDECSMGTHDCHPMALCTNMPGSFTCNCPSGYNGNGRKCFQYHHLHNMSVDCELDGMTLILINDPDLYDGRIFVRGQTDNPFCSKKLSALLANESEYHLMIQYAHCNVRLEEPNTVAVTVVIQRHPMFITERADAYDVRCTYPIGVRKVASHVGISEITTTKTIVETGVGPTCSLTVTNEQDQLVDTATVGQPLKLALTVYPNDTYAVLPRNCFAINLETGELYLLTDEGGCAIDTELFPEWTYRQLWLTTAKFRTFKWPDSSMIRFQCDCSACIESCPKVNCTKRHELIKQQRFRHIREIPRNTVDEELEKHIVKSAKWMAYSGALHVNEEEELVRAQRDMKRWKYQGLKTYEEPLDTLPKDICIHTLWIILSLLPLLLLLILIGLLSVAWRKKSSINMRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H910</accession>
    <name>A0A183H910_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3972</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002844">
        <property type="protein sequence ID" value="VDO38437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H910"/>
    <dbReference type="WBParaSite" id="OFLC_0000397101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000397101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000397101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000397101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24789" checksum="93A876E6AB64D99A" modified="2016-09-07" version="1">VRKLVDGANWRYKVHDGFDVTPTDTYKQIVSKVFSPVENIWRTASSCTLKKMYQPDLGEYRRSKSFSSLAPSYGMPLEDRDVQRYFGSFQSYVPKQSEWKFALEKYSKPRISRKHSLKTNPNINKDAFDFKVTPYRKLNEFPTSTSRIDNYNLYCRGRMHGVYGTGALFYPSNFIGEEDRRYERMYWGQDWMDYITPTARHATSFLLSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H946</accession>
    <name>A0A183H946_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002890">
        <property type="protein sequence ID" value="VDO38581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H946"/>
    <dbReference type="STRING" id="387005.A0A183H946"/>
    <dbReference type="WBParaSite" id="OFLC_0000400701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000400701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000400701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000400701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14062" checksum="8E44E64DA569A689" modified="2016-09-07" version="1">MLEDKSRISNTNKWYQKVQMCRRLPPRCSSVDGYHKLECYKLSLRNAQLPGVNIPLANIGKLENGHVISHSCLFLRQTTKYSENRFMENGNLLVFTVITDVVLEIVEEKHGKQNSDYLYTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9D7</accession>
    <name>A0A183H9D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002988">
        <property type="protein sequence ID" value="VDO38879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9D7"/>
    <dbReference type="WBParaSite" id="OFLC_0000409801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000409801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000409801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000409801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="4151" checksum="5296BCFC902E5AC9" modified="2016-09-07" version="1">MSTCMNDIVIRKQPQVKKSHLVNDLKNLHVLALPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9N8</accession>
    <name>A0A183H9N8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4199</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003097">
        <property type="protein sequence ID" value="VDO39245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9N8"/>
    <dbReference type="STRING" id="387005.A0A183H9N8"/>
    <dbReference type="WBParaSite" id="OFLC_0000419901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000419901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000419901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12317">
        <property type="entry name" value="RRM4_RBM19_RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO39245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000419901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="60213" checksum="2D79BF75AFFC7D12" modified="2016-09-07" version="1">MKICFFHECCSIILIINYSKHYFAGDTSLSLIIRGLPKTLKTKGIKDWFSPIKLKGMKIVRNSIEAIAFVTFFQESDARKALQRNEQFLGGSKLEITRVSSNQVSDRTEDYIHKTREAEVEASVGKILETGRLFVRNLPYMCSDEDLRYLFKKYGEISDLQVIVSKKTGQCKGFAIVTYVFPESAVAAFSALDGSILKGRVLHILPGEEKREMEDIGIVGKSAFQKTKIAKLKKDAGKSHSWNTLFLGANAVAETLAEKLDVEKSDLLLGQGEISAGVRLALAETRLVSETREYLLASGVCLDVFSRPAAKRSKTVIIIKNLTAEVDVDELKRMFARHGPVKQILMPPGGVTAILEMENSVDAQKAFSALAYSRFRSQPLFLEWAPYDVFKSRKLENKDENNDQKQRIIEIQTDEKNNEFSAEDKKKLRRSKKHRLVEESIKIAGSQENAEILNETKNETTVKDEGVEQQEVEKHIAEIDIDGTKEDDDLSLPGTTLFVKNLSFKTTDERLKNKFESRFRIRSATISKKRGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Q7</accession>
    <name>A0A183H9Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4219</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003113">
        <property type="protein sequence ID" value="VDO39311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Q7"/>
    <dbReference type="STRING" id="387005.A0A183H9Q7"/>
    <dbReference type="WBParaSite" id="OFLC_0000421801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000421801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000421801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000421801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29559" checksum="92E5FBBE09496D24" modified="2016-09-07" version="1">MCPERFFIHCLLASTALVNWLRYIWRLLLKCLRLRDSEDGGMEEVWIGVRRNLGMIIYLYIAKYSFCFLSCKIAVIVNSGAFPTQEAPSQLVSSNPFRWLSSLMFWLIAISVPYMMYQSLWRTVDESMKWTTGQDGYYEALAVEDHNTQENDKISFKSGDVLRVAPREYQPQKLGYILAWQVIFENKASFTNIYKQLFNISYSSSFSSKDGKKVGLVPIKKIRLTKRVVESPVFSGHDAVQLFDDVHASENYLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA29</accession>
    <name>A0A183HA29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4339</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003250">
        <property type="protein sequence ID" value="VDO39685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA29"/>
    <dbReference type="WBParaSite" id="OFLC_0000434001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000434001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000434001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF10">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000434001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20943" checksum="B2AF5A038B767DAE" modified="2016-09-07" version="1">MSRALRDFNSSANFFVHANNSTVKFFEAMAHKLAHWYTPDMGIMIHQCHTWEEPKCSYIPHKIANSWEWMYTDQKNPPYLLQLDCETDGGSKLMQLAKFGFYFMNSDNHRVCNQTAVNIAQKRMENGEIEVFKTRLSWGRFQFKVYWFIVDNMLKIPILGAMLKPYLPLIGFIIMITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA47</accession>
    <name>A0A183HA47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003270">
        <property type="protein sequence ID" value="VDO39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA47"/>
    <dbReference type="STRING" id="387005.A0A183HA47"/>
    <dbReference type="WBParaSite" id="OFLC_0000435801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000435801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000435801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000435801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7865" checksum="2F1D4E33DE2E8FB5" modified="2016-09-07" version="1">MVELCELKLVDQNLESQWPADIDQHIAQLDFQRSTDEEDTSLFSSMALDPSIISTDSLDIEKLHARCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB12</accession>
    <name>A0A183HB12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4676</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003669">
        <property type="protein sequence ID" value="VDO40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB12"/>
    <dbReference type="STRING" id="387005.A0A183HB12"/>
    <dbReference type="WBParaSite" id="OFLC_0000467301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000467301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000467301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22438">
        <property type="entry name" value="KH-I_PCBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02396">
        <property type="entry name" value="KH-I_PCBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="95"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000467301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24552" checksum="BDD30FC18112BCE8" modified="2016-09-07" version="1">MRQYDYNYNKLLFAIIAFVISLLFQEVGSIIGKRGDHIKLIREQSGAKINISDGSCPERIVTITGSTGTINKAFGMICAKLQQDLQALPNSIPKPPITMRLIVPATQCGCIIGKGGSKIKEIRETTGASIQVASEMLPSSTERAVTISGGADSIVECMRNICQILLEAPAKGNTLPYRPKPTFNPTLLASSAAAAAASLLQQQQQQQQQSYATLINPLDVSFLSIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBU4</accession>
    <name>A0A183HBU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004035">
        <property type="protein sequence ID" value="VDO41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBU4"/>
    <dbReference type="WBParaSite" id="OFLC_0000495501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000495501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000495501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000495501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15210" checksum="60586C9A41CE19AB" modified="2016-09-07" version="1">MSAYNGFKNHVTLSKHPARGKERENICGFYFYLESFGIFLAIWIDMNGFCMMSRSCLFPTLGHQNCWFRQYNIASNIDEVNHRHRCYMSCFRKSVISRLVCPLIGDFEKQSWNLSFNVFAVDIVNLLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCU3</accession>
    <name>A0A183HCU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5305</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004489">
        <property type="protein sequence ID" value="VDO42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000530401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000530401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000530401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000530401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25671" checksum="2803A2F7B16294CB" modified="2016-09-07" version="1">MTKTDTEEINSSHMYSDLEAELSADGSMHVKPASTHVIGVSWLSGDLVPLVRTDNIDTDKIATNKSGTLQDQNSGMKATQISLTTDSSESETNPELKSTSETFINHEATHFHTMTNDSAIFIEETETIRSNSDSGMTDKINLQSESNLNVEAETFQSIPETELPEFQLASTLKSISGKSDQTNDLGGMKSLITLTEKNETKVLVSKATTINLSIFSISVACLIITFFSQNFENLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD03</accession>
    <name>A0A183HD03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFR_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004569">
        <property type="protein sequence ID" value="VDO42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD03"/>
    <dbReference type="STRING" id="387005.A0A183HD03"/>
    <dbReference type="WBParaSite" id="OFLC_0000536401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000536401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000536401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="1">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000536401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27616" checksum="B84A5A5CBF064FDB" modified="2016-09-07" version="1">MTLLDSWKFYDPKGPISGDRSIPGIGIPGTGSDFQRFITYLGIPVIDMKLESAPLYNYMLYHTMYEIPWLLDNFLDQNCTAMMAVGQLWLEIGRDIADSIIIPFNLHDYGLVLSDFIDRMDQQLEHIGIPKAIGTKAYRVILNNLRGALTRFQIVANVIQEITQSVNTGHESISMKQAEMLNNRMQHVERAFIAEQGIYPERAEFRHLIFTTNNIHNDYGNLLFGGILDPALQWYNASITEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDJ8</accession>
    <name>A0A183HDJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">VEFS-Box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5557</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004840">
        <property type="protein sequence ID" value="VDO43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDJ8"/>
    <dbReference type="STRING" id="387005.A0A183HDJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000555901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000555901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000555901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21521">
        <property type="entry name" value="VEFS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="8">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000555901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31454" checksum="F64699A32BBB2568" modified="2016-09-07" version="1">MPKDLSIFFMQADRERRATKGNNAAYFGFRSRHPLMKCTQISTKQTDQEWLREFIIRQIEDFLDLSRVEKDFMSLWSIFLLNLNHKPLGRCHTYRTCRLFLQKHRQDILQNNFQNAWVFHLTALHEKEALDTDEVYDLTMRLKDNYDPNTDVRHVVYATRARLEAAASNAKREPPAWQKEPVHGPKISILRSSSVARLSSLEPNSDNEDMFKKFMNDSARKERRSSSCSVDEPSRHSTNRRQREPDCSKYLTSPRATQPPKWLSFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDL3</accession>
    <name>A0A183HDL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5576</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004858">
        <property type="protein sequence ID" value="VDO43610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDL3"/>
    <dbReference type="WBParaSite" id="OFLC_0000557401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000557401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000557401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000557401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11318" checksum="CF8D38A301471082" modified="2016-09-07" version="1">MLLYSHETAIAEVAHIMEIMRSSAIFKQNSYYASPFLFQLQIHCEDVSPWLKLTLTDTTNTAFRITAEVVNILLISRYILNDNFFEVLLSFYIFAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDM1</accession>
    <name>A0A183HDM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF2235 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5584</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004872">
        <property type="protein sequence ID" value="VDO43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDM1"/>
    <dbReference type="STRING" id="387005.A0A183HDM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000558201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000558201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000558201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000558201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38437" checksum="CCC68DFAD4EED060" modified="2016-09-07" version="1">MVYLFRLSGYKMKKRVGAIEEFVIQPISEGRSLHCVLAISGWIEDQGEHVFQQQWRHLWMSREQYVLRYESNYLVELGRAIDYLMSCAVSFAVQHTLLETAFAGLVTAVAWPVALLSASSVIDNPWNVCVGEQLAEVLLSRAHGSRPITLIGFSLGARVIFHCLMAMTKRSTCFGIIHDVVLLGAPVSASPIQWQQISQIVGGRIINGYCNSDWLLRFIYRAMSVQFTIAGTGPVTCKMEKKIVNFNLSHLIKGHLDYSRKLTEILEVVGVRVRPRRDESMLNMDKVARELNIGNSDFDVAEEEKIFSNSFKNGKEAQCVLNETRQMESEEEKSDVLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDT3</accession>
    <name>A0A183HDT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5652</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004967">
        <property type="protein sequence ID" value="VDO43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDT3"/>
    <dbReference type="STRING" id="387005.A0A183HDT3"/>
    <dbReference type="WBParaSite" id="OFLC_0000564401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000564401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000564401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055230">
        <property type="entry name" value="PH_Tiam1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23014">
        <property type="entry name" value="PH_Tiam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Tiam1/2 second PH-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000564401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19822" checksum="0F22016012BB56F3" modified="2016-09-07" version="1">MYYCNSVNYLVIGSVERQQGEQALTRMQALAEYVNEMQRLTEQYGRTIEEVSSKNGAASRMNFSQLLMFAHINWLNCPENRSRPIACVAFVFTSLILIFCPTLSKNKTKVYRILPIVEVEVNESNNQSSQSQYVFTLFHISSSRESVYHLCCCQAEIKNHFIKSIRKAATTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEJ8</accession>
    <name>A0A183HEJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5911</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005337">
        <property type="protein sequence ID" value="VDO44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEJ8"/>
    <dbReference type="STRING" id="387005.A0A183HEJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000590901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000590901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000590901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000590901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24317" checksum="F5B60AA87C4453CF" modified="2016-09-07" version="1">MLKNSRYNSCDFARAISGRISYGIVEVESPYDRFIGAQEILQKFIEGGDKTPLSKAIESYKSCLMNLVNLVFMSINQSLIVSVGSFYLLCLPQEDEARILHCRHFLYIFVHYVLRAFTVSSHSKNRANRPLFVAIPMSGENTGWFLITGCMPANTDYEDSNQKSFIGRAMQKVVENFIRDGARRDFFDSAMVMIRSDQKARFFDGLQATLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEZ3</accession>
    <name>A0A183HEZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNase_Zc3h12a_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005541">
        <property type="protein sequence ID" value="VDO45241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000605401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000605401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000605401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028079">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14626">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zc3h12a-like Ribonuclease NYN" evidence="1">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000605401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36378" checksum="3F440B670B3C450E" modified="2016-09-07" version="1">MEIHVGVEDNANNKYILCNMQLSKIISFENVKRLLVERTAGTLLRPVIIDGPLIGVSYDQEYELDDRIGCLENYVRRVKSTKKVRRGFRIMKPYPVEALVKILFYFIARGHKATAFLPIFFNEQLNESCCNRCALVSNIEQFRELVLLKLIKFLSNENFANEIKHRTVNCHGILVTGPEAAYFNNSNLHREGHPEENITSDNAMGTSCDLMYSTMIPELLLDKSKLPVIIPLFRPYNHRLIISLDVIRWKAILQVGEQEVSISQRKLLIDEQLMLQMQFGLLSKLVIMLDGQFPCGPSDADIVPLFRHALGLADQAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFG0</accession>
    <name>A0A183HFG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005795">
        <property type="protein sequence ID" value="VDO45826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFG0"/>
    <dbReference type="STRING" id="387005.A0A183HFG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000622101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000622101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000622101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000622101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25232" checksum="C39F49DA967EA695" modified="2016-09-07" version="1">IAANKTSSNSPGLCGLSAYQQQHTTINNELYSNSCITTTTSSTSLYSSTVSSSFTQRPQAIVTPITAIVTATEPVTVNEVLCTSFSESETKNMEDDKEQNNGIIPDCKNNNTFNEEEPKWNNQYCIQCSTANSQRNICNSNKSINTSSNNTATAIDSNDFHNILNHHITTMIDDSQSTINDSDLIDTQKIGNNYANDQTLSSLLTIPDHSTVVSAQSPKCLSPVVEDSNSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFQ1</accession>
    <name>A0A183HFQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005931">
        <property type="protein sequence ID" value="VDO46128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000631201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000631201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000631201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000631201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8456" checksum="6CFC067483013690" modified="2016-09-07" version="1">MDRLFAPYLLQLQMILFIGMEVIRTAKDENARVISIVEQFEDDTLWEFHSKSVRRAQVSKKTWDEYVKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFS8</accession>
    <name>A0A183HFS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6340</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005976">
        <property type="protein sequence ID" value="VDO46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFS8"/>
    <dbReference type="STRING" id="387005.A0A183HFS8"/>
    <dbReference type="WBParaSite" id="OFLC_0000633901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000633901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000633901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000633901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26157" checksum="67146142D3BC7273" modified="2016-09-07" version="1">MNVRYFEPMKHWEDGDIFMPKQLPWYPYAFQTPMSRATLRSRPLLKSFHNFLITEAELGNISRQEAVSMIPPLLLDIKPHHKVLDVCAAPGSKTMQIIEMMHCDEKIPEGLILANDIDNSRCYLLVRQALKRMPTSNCIVINEDAAFLPSLSIDKDTSEPLLFDRVLCDVICSGDGTFRKSPDMWQSWNPVKGLGLHKLQVNIAQRAAQLLAVNGEFFSISFIIFKFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFY3</accession>
    <name>A0A183HFY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006048">
        <property type="protein sequence ID" value="VDO46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFY3"/>
    <dbReference type="STRING" id="387005.A0A183HFY3"/>
    <dbReference type="WBParaSite" id="OFLC_0000639401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000639401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000639401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000639401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21117" checksum="57BE4DC8C0C581F0" modified="2016-09-07" version="1">MLMQDAEFMGQHYGSLYERYKHMEQKYKDRCNENAQLNLVDNFYDISNESNLLVLYLKELADCKSILMNHQSVLKKLQESAYQSQSENTQLRQNCSRLTWELDKTHDKIDVFRNAANENEKLYVECTKNSAQSVGKLKKDIEDWNDVLQSEMKKITDCCGEFLYLFLLCVTFESKLSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG66</accession>
    <name>A0A183HG66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4398 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006173">
        <property type="protein sequence ID" value="VDO46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG66"/>
    <dbReference type="STRING" id="387005.A0A183HG66"/>
    <dbReference type="WBParaSite" id="OFLC_0000647701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000647701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000647701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000647701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15222" checksum="9007F65961B87C01" modified="2016-09-07" version="1">MKDINVQYLSISEDTKYAYEAADKAIRQAEFAEAANEQLEISFEKAKELLSSQNVGNELPQARAEELRKRATQLLHKTQRHRSDISQLSANMDAFDVRLADYNRELTELHSRIDTVTAQVHKQIEYYSTCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGD1</accession>
    <name>A0A183HGD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006284">
        <property type="protein sequence ID" value="VDO46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000654201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000654201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000654201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000654201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25047" checksum="54BF4BA0A61BC75C" modified="2016-09-07" version="1">MLSRINCLEFNDYLEKSDEQKITAIKKLTKTKEEKRKTKEYDEDHEKKSEDEAITAIEILPTTEEEKKKTKKYDEDYEKKSEDEAITAIEILPTTEEEEKERMMKKDKIYKGKMPVSEITAASASITALADSIKVLQSLSASLSSPSKPLVETIQRNNKIPERITFLTIYETEKERDNDENEDDQKLEVVQGENKQKDSDDEMMYLPIRSAKGIPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGE0</accession>
    <name>A0A183HGE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6552</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006293">
        <property type="protein sequence ID" value="VDO46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000655101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000655101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000655101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000655101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8920" checksum="79ED2CA9F7195C58" modified="2016-09-07" version="1">MKQEISSNYVTKMQKLHRPPYHSHIWYRDVAYACRSNFGFIFSTVLAVLALRSVARIRGLQVPVQFQVTFGDTFIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGI8</accession>
    <name>A0A183HGI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6600</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006369">
        <property type="protein sequence ID" value="VDO47057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGI8"/>
    <dbReference type="STRING" id="387005.A0A183HGI8"/>
    <dbReference type="WBParaSite" id="OFLC_0000659901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000659901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000659901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000659901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25731" checksum="A53032B91651D711" modified="2016-09-07" version="1">MKDEDPYVRKTAAVCVAKLHDINASLVEDQGFVDLLNDLLSDSNPMVVANAVAALAEINESHVLIEINSQTINKLLTALNECTEWGQVFILDALSSYQPKDEREAQNICERISPRLAHANAAVVLSTVKVLMKLMEMLPENSEFIGQLTKKLAPPMVTLLSAEPEIQYVALRNINLIVQKRPEILKQEMKVFFVKYNDPIYVKMEKLDIMIRLAQQNNINQVLSELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHJ8</accession>
    <name>A0A183HHJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6958</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006950">
        <property type="protein sequence ID" value="VDO48652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHJ8"/>
    <dbReference type="STRING" id="387005.A0A183HHJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000695901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000695901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000695901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO48652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000695901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="23208" checksum="F03964C5BDA791A2" modified="2016-09-07" version="1">MYLDLFLRLLTDEMRQAIGERSRVIWYDSVTVDGELKWQNELNDKNQRWFDITDGIFLNYIWNVKQLLTSAVRAKHRHRDIFVGIDCYGRGCHGGGGWNCHEAFIYPHQNNLSVALFAPGWIAETMPCQEIIFNSLRFWDRLIAFVRPHPLIKLPIDTDFNFGYKCKSDCKVSFTFIYYYLCYSFYSYYIYYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI74</accession>
    <name>A0A183HI74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7186</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007327">
        <property type="protein sequence ID" value="VDO49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI74"/>
    <dbReference type="WBParaSite" id="OFLC_0000718501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000718501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000718501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000718501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7978" checksum="2DA13C9B43465746" modified="2016-09-07" version="1">MLINATRDASRFKKLQKLASNGTGQISENFDDNDDAPYTPREIAHMTDILFPQVREYLLDRHVTAVSNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIF5</accession>
    <name>A0A183HIF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7267</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007459">
        <property type="protein sequence ID" value="VDO50116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIF5"/>
    <dbReference type="STRING" id="387005.A0A183HIF5"/>
    <dbReference type="WBParaSite" id="OFLC_0000726601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000726601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000726601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO50116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000726601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32244" checksum="E8DFA45372827F8B" modified="2016-09-07" version="1">MVHRDIKGANILLTHSGDVKLADFGIAAQITATIGKRKSFIGTPYWMAPEVACVERRGGYGVECDVWAVGITAIELAELQPPLFDLHPMQVLYLMTKSSYKPPTLKDKYKWSPFFHDFIKQCLTKNPKKRPTPDKLLASHHFVLGALSSRMTRDLLDKVNNPGGLSSASVFARQFSAMYTDDDEESEELTISRIKSRGRACPRVAQDAIRVCDDANALMARIWGEPSTSEVSVANLGRHYHEDRTLPAKEHPPLPDVVQALSLLNDNDGVIHDIDDGTFCSLEQINDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIJ5</accession>
    <name>A0A183HIJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCR4-NOT transcription complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007524">
        <property type="protein sequence ID" value="VDO50310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIJ5"/>
    <dbReference type="STRING" id="387005.A0A183HIJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000730601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000730601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000730601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000730601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24390" checksum="6EDA1B0F31217CE6" modified="2016-09-07" version="1">MEALIGIMEGARMENELRARKYVARVLWLMKKLSVYGSIAEKEVDAKLEKYGTGIPANNWLPCGLKLQFRSVVFGLVEAYGNLFYCIQALSLLHFDEVLPQLVAELQIRPSIAIAHIISHIGESSEQQVFYAIAASQPLDFILENVSTALDPLKNDQDNPVTSQKLFRDIIRKLCQSRPVEISSLCRLLFELNSVKEHWLEHTLHKVNHLKHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJX0</accession>
    <name>A0A183HJX0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS7781</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008345">
        <property type="protein sequence ID" value="VDO52485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJX0"/>
    <dbReference type="STRING" id="387005.A0A183HJX0"/>
    <dbReference type="WBParaSite" id="OFLC_0000778101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000778101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000778101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048584">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21251">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO52485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000778101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31490" checksum="2E69169DCD6B606A" modified="2016-09-07" version="1">MASLIPFNQIRQNTVNFFMRKPARELWKTVTSLSPAGIKKGRSKTRQSVLNLQKFYRIGAGPIKVKYPGLNTPLTVPNDEPMMVMEKTKEEIDAVEERLKNIIATRPSKKRMKEKLHPLERGFAGVRVEGQKLGPPPPVGDIYFDDFQTYCLQLRRTTNMTSYGRQHTISALIITGNGNGLGGYAIGKAGLKHHIRAVVNGMKMASRKLVYVELLENRTIYQDFYAECRGTRIFAQRRPKDFGIVAHPRLVKICEVLGIKDLECKVMGSTRNYIALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKC2</accession>
    <name>A0A183HKC2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7935</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01008625">
        <property type="protein sequence ID" value="VDO53239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKC2"/>
    <dbReference type="STRING" id="387005.A0A183HKC2"/>
    <dbReference type="WBParaSite" id="OFLC_0000793301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000793301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000793301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WWE" evidence="3">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO53239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000793301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23341" checksum="2277888C027E2362" modified="2016-09-07" version="1">MNFRFLSSHLLIYLSKAFFADFARTIKFLIVGSKEGDHTAFEIVDRPPQHLQELVYLAGELMPRLPVDGIFEIDNVMLRSHGAYYDFQPTLWYWKDDSNQWLPFTHFDSRLIEMAYTTSETEVNLQINGNVYKIDLQRMVQRNHTSGKERAIQRRASVFKSKTVSLEDDRRLELMKTEPVLLEQVVQLLLPILVEIDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKE3</accession>
    <name>A0A183HKE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7951</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008654">
        <property type="protein sequence ID" value="VDO53332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000795401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000795401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000795401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000795401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8651" checksum="B565469C3F7AD5F8" modified="2016-09-07" version="1">MPRMRHQQASDTIFMTASSRSNHARSFSRSPSQVYPAPGPIPLDNNDDYQQNNDKQKRLVKLFIQSNYFFLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKI9</accession>
    <name>A0A183HKI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008729">
        <property type="protein sequence ID" value="VDO53575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKI9"/>
    <dbReference type="WBParaSite" id="OFLC_0000800001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000800001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000800001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000800001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28681" checksum="3F2BF1A98A2E950A" modified="2016-09-07" version="1">MNIGLQNQLRNNQYREAERMGNVSCPSCGSTIVGAGEALCALTHSNANLYDDSFISNVSDAPDEVKSFRNKKCSTPATAPPPRICSPIMKSINIPPEQMATNEKTCVKSPHSPLRRSYSDSELPSMVSTAEVESVSQECLLQLTHLPTRGELLSESLDGTSFSSDEEATTIELIEKQLRRRGDNVRFVPPRRAVRQATFRRFGRNELSALAEFDYLQNLSTDASGIATSSDYSSPEGRLGLGKERRMIEDRTLCKLKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLP8</accession>
    <name>A0A183HLP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8410</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009486">
        <property type="protein sequence ID" value="VDO55556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLP8"/>
    <dbReference type="STRING" id="387005.A0A183HLP8"/>
    <dbReference type="WBParaSite" id="OFLC_0000840901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000840901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000840901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO55556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000840901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26799" checksum="AB16C0ACDD243A9F" modified="2016-09-07" version="1">MAGMPEKTVEYLLETRIDAQTDDGLMDKFLEDFILTHIIHMPVNILCSYLKNYYMRGSTVRMDDTLPIDDYEHKIVAKRRVVAFLNLWVQILGLRFFLDPASNSFVEELYCYVLEDSRQFPEMLSNLEPMCAIRQLRESAMQTINRHSSLVLDCGNQVIYLSDTSSFVMNIRLDKTAADICEMAKTKMRYVSSSNEELQLVEVKSSGGKFCNLIKTFKFTSSSQIAFQIFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNF4</accession>
    <name>A0A183HNF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphate carrier protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS9013</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010656">
        <property type="protein sequence ID" value="VDO58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNF4"/>
    <dbReference type="STRING" id="387005.A0A183HNF4"/>
    <dbReference type="WBParaSite" id="OFLC_0000901501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000901501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000901501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO58384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000901501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19273" checksum="D1CDA04B52BCBA5B" modified="2016-09-07" version="1">MSRQGCTLILIQMLAFSVFLLIYITIRWCRTIVLLGYVSKSGDEVQFGSPKYFLLCGLGGVISCGTTHTAIVPLDLVKCRIQVNPEKYKGIIQGFRTTVREEGFRALAKGWAPTLIGYSCQGLGKFGFYEMFKIFYSDVLGEVWFLCCFLSAISSLLFATLDSFEWNDFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNW2</accession>
    <name>A0A183HNW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9175</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010980">
        <property type="protein sequence ID" value="VDO59035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNW2"/>
    <dbReference type="STRING" id="387005.A0A183HNW2"/>
    <dbReference type="WBParaSite" id="OFLC_0000917301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000917301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000917301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000917301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23889" checksum="ACB1DF612A6D17F4" modified="2016-09-07" version="1">MLLVKSILYYHVQEIKKETKPVRLINLLYLANDVIQNSRKHCPHFMGMFYENLEPAFRHVSIHADADAVVAMKKILRVFRERQIYSEAKVDRLTNAVTSSLTGIRLVEFNIELGGTVLSTESIQKSRQTPTTPPNIGKAVDSPHLSTPTVDTDSPEPKKSKMDGENFDIKVMTRVTEDVISLLKKLEDPPSADAETRYKLILHFYTFLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP90</accession>
    <name>A0A183HP90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-synt_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS9302</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011266">
        <property type="protein sequence ID" value="VDO59610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP90"/>
    <dbReference type="STRING" id="387005.A0A183HP90"/>
    <dbReference type="WBParaSite" id="OFLC_0000930101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000930101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000930101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="9">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (D/K/N)" evidence="8">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000930101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22185" checksum="CAAEC49C0394D192" modified="2016-09-07" version="1">MFFILRDGTGFLQVMLTDKLCQTYDALILTTESTVEIYGKIEEVPEGKTAPNGHELKADFWKVIGNAPPGGIDNVLNEEAGIDKMLDNRHLVIRGENAAALLRLRAAATRAMREHFYNAGYVEVAPPTLVQTQVEGGSTLFGFDYFGEPSYLTQSSQLYLETCIPSLGDVFCIAQSYRFNYFHFLFRKGLKKDEVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPL7</accession>
    <name>A0A183HPL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011538">
        <property type="protein sequence ID" value="VDO60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPL7"/>
    <dbReference type="STRING" id="387005.A0A183HPL7"/>
    <dbReference type="WBParaSite" id="OFLC_0000942801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000942801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000942801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000942801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14070" checksum="22116F8EDE6D2DAF" modified="2016-09-07" version="1">ENNPDIAIRLFRTHINCDPFVTGIYEHCRVRKRRCDWKSKHQVLSIVEEMSIGGDYHLKLKIFSGRKRGVKTILPRGLQLWNTETIGHDVFKIYSKWKGDAPDPTEITSASHPNLIHRKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPW1</accession>
    <name>A0A183HPW1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9522</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011751">
        <property type="protein sequence ID" value="VDO61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPW1"/>
    <dbReference type="STRING" id="387005.A0A183HPW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000952201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000952201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000952201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000952201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16210" checksum="B2856669736AB0D2" modified="2016-09-07" version="1">MSRGSSAGFDRHITIFSPEGRVYQVEYAFKAINSTNLTAVGVKGVNCAVVAVQKRVPDKLIVAESVTSLYQLTPSIGCAMVGMIPDSKFQVKRAQIEAAEWKYKNGYNMSVEQLSRRMADLNQYYTQNAELRSLGCGKYMFYIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR01</accession>
    <name>A0A183HR01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF667 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9912</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012666">
        <property type="protein sequence ID" value="VDO64391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR01"/>
    <dbReference type="STRING" id="387005.A0A183HR01"/>
    <dbReference type="WBParaSite" id="OFLC_0000991201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000991201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000991201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000991201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10061" checksum="8177E2179A84DBA4" modified="2016-09-07" version="1">MLLELRFDFDRSEKCFFYSDQSAPLQWKMVKAVDEFKDQTAKYVVSLQSTIFVKNYGQLISTPIILNDINYCLSIWIYIKEFSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRI5</accession>
    <name>A0A183HRI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013108">
        <property type="protein sequence ID" value="VDO65791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRI5"/>
    <dbReference type="WBParaSite" id="OFLC_0001009601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001009601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001009601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001009601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20647" checksum="4AFBDDE5FD80F3FC" modified="2016-09-07" version="1">MCSSAKELLRSKWALKVLRIYLNDFKDIIFDGGLIIYQFGKTLIQSSITKIIQLPKNVVESSINEFQHLFDTGPVPKDFDYSILMINHFWDYIIINAKCYGEDFASTFMGHVIFSRMAKSNVLSFIFLHILLPKLAFLLHRKISMVNCHIKLKLNFNFKLNLATNLVQIWILTILGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRP8</accession>
    <name>A0A183HRP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Syndecan domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013257">
        <property type="protein sequence ID" value="VDO66291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRP8"/>
    <dbReference type="WBParaSite" id="OFLC_0001015901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001015901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001015901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001015901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19662" checksum="36BB4DBD6166EAFF" modified="2016-09-07" version="1">ISIFIKSIILQCPQASFCLPISGERRHLPTWIEPYLQRSITVTSSSTIRILLPNASEPSLDNDESSISDELVAESDDNLVNVAYDSKCARVCAVAVEKALKKEEECHLDGIPIYVVIVIVIISFAFGVAFVATLWFIHNRTGRYNNSIGYSFDILVNLRSTSARIFFPSSLFDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS28</accession>
    <name>A0A183HS28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS10284</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013536">
        <property type="protein sequence ID" value="VDO67290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS28"/>
    <dbReference type="STRING" id="387005.A0A183HS28"/>
    <dbReference type="WBParaSite" id="OFLC_0001028901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001028901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001028901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF51">
        <property type="entry name" value="CUTICLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552623" evidence="8">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO67290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001028901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26281" checksum="35752DFA6D34787F" modified="2016-09-07" version="1">MLRLISVLLFITAVNAIPVDNGVEGEPEIECGPTSITVNFNTRNPFEGHVYVKGLFDQPGCRNDEGGRQVAGIELPFDSCNVARTRSLNPRGIFVTSVVVISFHPLFVTKVDRAYRIQCFYMEADKTVSAQLEVSEMTTAFATQIVPMPVCRYEILDGGPSGQPVQFATIGQPVYHKWTCDSETVDTFCAVVHSCFVDDGNGDKVELLNADGCALDKYLLNNLEYPTGMLFVLEKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS62</accession>
    <name>A0A183HS62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endonuclease_NS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS10325</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013649">
        <property type="protein sequence ID" value="VDO67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS62"/>
    <dbReference type="STRING" id="387005.A0A183HS62"/>
    <dbReference type="WBParaSite" id="OFLC_0001032301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001032301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001032301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="5">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001032301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15220" checksum="05C61265E4D97E5E" modified="2016-09-07" version="1">MILHGDELARVQPSQILTGSSSTLDIDHMKEQPSRASQIMRYGYPGFDNLRTFEDYVLSYDRRNRIAHWVVEHLSSDRLVYNSSVDRSKSAAGNHRKSQNAVDQTFLLSNMAPQVGKGFNRDKWNELEKHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT98</accession>
    <name>A0A183HT98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2835 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014592">
        <property type="protein sequence ID" value="VDO70721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT98"/>
    <dbReference type="STRING" id="387005.A0A183HT98"/>
    <dbReference type="WBParaSite" id="OFLC_0001071001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001071001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001071001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057775">
        <property type="entry name" value="USP48_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24543">
        <property type="entry name" value="Usp-48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP48" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001071001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14204" checksum="6F86EEF2EAA1CC5B" modified="2016-09-07" version="1">MKEIRLAIGELIRTAVRRTIAVKSSTPQIYERVICRNFLKNMISRSRVRNPTIPTICQDCMLCSQHRKPCVLIDNTEGLAVPLTLEEWQKILTAMQIGEDDVILISLDNKGYFFKFFSEIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUD5</accession>
    <name>A0A183HUD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11097</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015581">
        <property type="protein sequence ID" value="VDO73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUD5"/>
    <dbReference type="WBParaSite" id="OFLC_0001109701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001109701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001109701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001109701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12460" checksum="4FA7FD0384837B88" modified="2016-09-07" version="1">MSKEQPEKSSEEEEKMEASSTFEPFFEVGPITFSGDPSISTSPGASATASASVESTNPDLPSVLENIPATELWAQYIKCLMMAAPSNVGRVEFQRNVGLEAEKYLEKLLKILPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVC2</accession>
    <name>A0A183HVC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WASH_WAHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11435</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016507">
        <property type="protein sequence ID" value="VDO76438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVC2"/>
    <dbReference type="STRING" id="387005.A0A183HVC2"/>
    <dbReference type="WBParaSite" id="OFLC_0001143401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001143401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001143401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001143401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18218" checksum="94EAE77A6855AB3D" modified="2016-09-07" version="1">ISFLQLCGVLEEINSSLTSKVNNVSDAIQENASRIANACVQVSNLNNRLSLFAADQFIESNKIVVSSFVVPSGMFQRVGDDTSVCTNPPLNSQTIIPNKQTGTIDNLRQAVSMGLELMRTRFKRIDIRPEDLDEDDDPIFASIQNIIVFQDENLSRPLPFLIGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX51</accession>
    <name>A0A183HX51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12054</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018214">
        <property type="protein sequence ID" value="VDO81501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX51"/>
    <dbReference type="STRING" id="387005.A0A183HX51"/>
    <dbReference type="WBParaSite" id="OFLC_0001206301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001206301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001206301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO81501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001206301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12413" checksum="E3FA841242D99C85" modified="2016-09-07" version="1">MFAIGEIFSLTGYADSSVSMFSSNIVHPFHDNMLFDEAFIPTRSPNPVDHRGRKIYLNAYAVDFWRLESKKALERDNGISENRIWALIHSFSVCYFKYFSFFTRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZB1</accession>
    <name>A0A183HZB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12823</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039946">
        <property type="protein sequence ID" value="VDP12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZB1"/>
    <dbReference type="STRING" id="387005.A0A183HZB1"/>
    <dbReference type="WBParaSite" id="OFLC_0001282401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001282401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001282401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001282401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71197" checksum="051F688ABBB273C8" modified="2016-09-07" version="1">MGSVESGELRPSTSSTGTVERGVEYSLADAADQVHRLSNLKSLVDFNSQSRKGVEEEGIRFGESMQSAGIQAQQQSPPKSVGQRIKETLQTSKSQLCRSPNVADTSLVSSPMSPPPLGAAEVNTIRIIGQYLKNLGLQETVATLFAESGCRLEDTLAVRLREYIMAGEWDHALGIVDKMSPFVTHLNLLRIREKLYEEKFVDLLGKERVLEALSLLTVDFPSDPAFFDRRNFLATLLYVDPKSVDVCAKTGAHRTERERNALIAEIQQLLPTTVMLPCNRLEKLLTQSWKMQCRECYLHVREDFDVSPEYILEDHQCDWDHFPMFTSQVLTKHTDEVWCAAFSRCGKYLATGSRSGAAHIWKIINEATVEPYKELTGRNSSSLLTWSDDGVLLAVSAAEGHLADVHIYDVHSGITFCVIENRANDSTVMSFVPNSSFSYRLVCADQMGHFCQYALSKNSVKSEGKFEGYRIRAVHCLRNGSVLAADTHNRVRSYRFSDDSEVTLIEELSQISTFVVDKSERRILIDTKLHGLRLWDLRTRTLIRAFVGAPHQDFIIHSTFGGPEQSYIATGSTDECIYVWKQSSEELIAKLAGHTARVNAVAWNPRLPQLVSCSDDCTIRIWSPLVGIDSSTIQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0I5</accession>
    <name>A0A183I0I5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ets-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13247</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040108">
        <property type="protein sequence ID" value="VDP13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0I5"/>
    <dbReference type="STRING" id="387005.A0A183I0I5"/>
    <dbReference type="WBParaSite" id="OFLC_0001324801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001324801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001324801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08757">
        <property type="entry name" value="SAM_PNT_ESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="5">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="252"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001324801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38627" checksum="48FB9021DD98F412" modified="2016-09-07" version="1">MACISEKHTAISPVAPIAAAFNPSLMCLPALFDHFGGEILRSHMNPAAAQFKPIPNNERVDLTRFLSKEPQEWTMGDVIAWLLHVAERNDIPIEDLEMQKFANCTGMVLIQMHETDFQQRDAVYGSLLYAEFRKLLIEERSINKCAYKSPERASTSRVTDDARVSCINNGLSVNPSALSSLLMSGSNSVNSSSTQPLDTLSQVGTDISGSGTFSFNSPVGSDETFMLRPTYCKVRKNKDGRPRKHSQHTKGNKLWEFIRDALKDPTTCPSVVRWEDPAEGVFRIVESEKLAQLWGERKNNQKMTYEKLSRAMRTYYEKRILVPVPKTGLYPKKLVYKFGPSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0L8</accession>
    <name>A0A183I0L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIP120 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13280</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040123">
        <property type="protein sequence ID" value="VDP13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0L8"/>
    <dbReference type="STRING" id="387005.A0A183I0L8"/>
    <dbReference type="WBParaSite" id="OFLC_0001328101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001328101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001328101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001328101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19040" checksum="83F0E77FB325A1B1" modified="2016-09-07" version="1">MGPFKHTVDDGLDLRKAAFECMYTLLETCLERLDVFEFITHMENGLKDQHDIKLLTYLMLARLAALCPSQVLQRLDSLCEPLKTQIQARAKANAVKQENDKQDELRRAALRVVVALQHIPEADRQQQFADLLAIIRSSTEINAVYQLVERDAVHRLYTSDSVMEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0W7</accession>
    <name>A0A183I0W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13379</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040170">
        <property type="protein sequence ID" value="VDP13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0W7"/>
    <dbReference type="STRING" id="387005.A0A183I0W7"/>
    <dbReference type="WBParaSite" id="OFLC_0001338001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001338001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001338001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001338001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20018" checksum="9FD5359C3C8BE0E4" modified="2016-09-07" version="1">FFFFFYSERETVFAITKKLGVLKIASAVDDRTRYVVSDQEGMRTVNVMRALVKGVPIVTIEWAYRSLEIGGWLKGSDFFVPRWKTAHKAWLNGHMAHLFSALGPFYVSSKCEPEANHLLYLIKCCHGKTTESLNRAVIFVSPQSEWRTIMQLRKDTDTQATYITEKSLLGTINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1T8</accession>
    <name>A0A183I1T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13700</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040346">
        <property type="protein sequence ID" value="VDP14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1T8"/>
    <dbReference type="WBParaSite" id="OFLC_0001370101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001370101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001370101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF30">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552725" evidence="5">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001370101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14990" checksum="D5CC36AE05D66FBD" modified="2016-09-07" version="1">MLALKVIIFSSLLITLAYCKIQTIAVKGQVACGDKSVTNVHIELREADTWTPDDSLSSTHSDRKGYFEVSGQEDEMGNIDPYLRITHNCNDGVIDPKCSIVDDYQIPKDYINDIYNMGIVSLNIAQDGRRMECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1W5</accession>
    <name>A0A183I1W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TraB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13727</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040360">
        <property type="protein sequence ID" value="VDP14501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1W5"/>
    <dbReference type="STRING" id="387005.A0A183I1W5"/>
    <dbReference type="WBParaSite" id="OFLC_0001372801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001372801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001372801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001372801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51955" checksum="54F1A758D8E8166C" modified="2016-09-07" version="1">MSANGIGADNITPRQNKEEQKLVPEPNLDEIVLSEDDAIHAKTKVMSGDSEPTDVDIFCTETLSERLKNDDTSDTISAEEQNVVSVADCSSNFFDPISTSRVSSEDYGNDLHLDNKMEQTDMQKSERIHVEQRRYFGGFMFDRDRHPNPELPKETVTILNYPFLPTAIPVGDDENEFRKSLADAKRDVLQTIASTQPDMVMVELCPSRISILSMDEVTLLEEAKNLNFDKVINTIKQSGAIQGILHVLLLSMSAHMTKTLGMAPGGEFRAAHKGAMDVKMCKLILGDRPIHVTVQRALGSLSFFQKLRLFYHIVLSHKTTITQEEVERCKKSDMLEELLKQMAGEFPLLSKIFVEERDLYMTNALHTLLKKSTFDKRVAWSKTDAAWQPISVVAVVGMGHVPGIISNWNKRIDVGDLLIIPQPTHTEKFIRLTLKAMIIGVVGYVFYQVGSKVVNRVQMLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Q1</accession>
    <name>A0A183I2Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epidermal growth factor receptor substrate 15-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14013</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040535">
        <property type="protein sequence ID" value="VDP15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Q1"/>
    <dbReference type="STRING" id="387005.A0A183I2Q1"/>
    <dbReference type="WBParaSite" id="OFLC_0001401401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001401401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001401401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF176">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="300"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="413"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001401401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="723" mass="79915" checksum="95EBCBB1F5DB18B5" modified="2016-09-07" version="1">MNLSTATISQPYTYIYESFYKELIIELWGYFQMNMRGKDLVPAQEAAAFLKRSNLSVTTLGQIWELADYNRKGCLDKTGAFIAFKLVAAAQQGQPISWNSLLLKLEPPSFASRSATPSIPNFGATSASFGENWAISPMDQAKYESIFDGLNPVEGKVAGNKVRPVLLNSGLPSASLARIWELADMDKDGKFDRIEMCVALHLIYCALQGEPVPNVLPPSLIHPTKRELVQFSSSVPPIPVYQRGIGRQRTGSVVSLDDSEQQASRSERVRSQSVQPTTVTTSVLFPPSFSLSPATAWPVQSASYEATFKQADTDQDGFVSGADVRDIFLATGIQQNTLALLWSLVDMKKNGMLNLEQFALIMYLIENHKRGRPVPSVLPPNLIPPSFRTVEAPAATVSSGYTMDAVPTGNEELDALLREVEKLILDRREADQEIVQLEADMTIELTTLESTVTQLEKQKGEAEKRLEALDSHIAQLERTVEQSKEKIKEEEKRLNELHSQITQNEEDKTTNEELLHVQREVNSLEEEKKTLSVTLTQHNATIEKASLELTKLERKFANTEEITKRIETENEKLKKTAERLTQLMESNDVETLNKEKEDLFGVLTEISPVIVDGFQNDPFAASTRPGIGFETDPFAGTINSSFTNFDAFSGKDPFGSDMNNTKSPSTTVKAPPPRPAPPKSLKTPVEPDPFSGTDPFAGSAATVTATTTDQFANFANFDAFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Q4</accession>
    <name>A0A183I2Q4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14016</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040537">
        <property type="protein sequence ID" value="VDP15276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Q4"/>
    <dbReference type="WBParaSite" id="OFLC_0001401701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001401701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001401701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001401701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40858" checksum="F31F393F1562256D" modified="2016-09-07" version="1">MINFDVSTFGLVVIDDLQFTGLLCHEVTTPPSTTINPLLIKQLFSLKPYPNVLIDSIPTLNCDFNRKCPQWESDGHWSVGMVPTDKDSFALPSSIKDKVSVAVLNKSMATLQSRKVPCASKAMIFVAYFRTEKAELMVCIEKKCVNTKHEHSALNTKSKQNMDNFWFTFFGWLSMKVDRQKPFFIRLIAKSTGPGLVIIRKIETAGNWCPLLSLSQYACETISCTFSQSFCGYKTETDSRANVFFTSDSKGTTANINKGPGLAVLRSPQFKLSRPVELQIKIYQSTFGSQTFLCGDDFSSLYDCQPILGPKIELPTTEEIILPLDQEAQNFTIVAVHDKFDEFGAAKFTILKIDLLDENRKLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I309</accession>
    <name>A0A183I309_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040611">
        <property type="protein sequence ID" value="VDP15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I309"/>
    <dbReference type="STRING" id="387005.A0A183I309"/>
    <dbReference type="WBParaSite" id="OFLC_0001412901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001412901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001412901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001412901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="42818" checksum="8568B4BA984D2B38" modified="2016-09-07" version="1">MLKCFFTQSSSLNNESGSKDCSLVKAKISDFTAVSAETTDSATLTVLAANSMATASNTMVNAIGIPILNLDQDGTDETIRDLILTLGHTQGIGDISTAIESSFATAATCIDELFSHHCTSGVSVFSSGNDDDDSHADNEDDKEPTPSTSGNYLDEWTPQYSSSLSIFATLSSGNFLSENEITQIFSRYGDIKEVKWIQISDNNGYIIVFSNESEKENAIKICGNKMETKGRVLKLWSFKQAHLFVNSNLAVIETTNHTSHQLTTDKDASDPYIIADAKLFGFTDPFQNNINSGINKHQIHYHPDASTMTLNEDMPSPERPGTRPLPTTAFLLKQISEANNMFETGQFYERTSHNSGSEKNRFLNLPAPYHLLPDTPYFRRAPIVPPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I336</accession>
    <name>A0A183I336_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3398 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14152</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040627">
        <property type="protein sequence ID" value="VDP15688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I336"/>
    <dbReference type="STRING" id="387005.A0A183I336"/>
    <dbReference type="WBParaSite" id="OFLC_0001415601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001415601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001415601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Dedicator of cytokinesis C/D N-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001415601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34547" checksum="1D423C9138AB3474" modified="2016-09-07" version="1">MSSQGTGGQRAFALKRNKMTAADVRRHIMTGSLLLHPQNATQMDATDTSPQTINLIEIVEPLDVEDILSQRKNNSSMYEHANNNLRRVAEFPADDIEVRLVHRDQITIESPIPSNLSGVDPLVKDIIQTYNDSFSLVQRKYLQYSSGEAYTRLLMERPIIAQTTPKQIFEVDSDRSIGRSVSTVGEDQIAKRDSHGSYYSSDSMCTVGSSSGGTNRDDILRAPQQLHSLASDPTVPGVVQRISNAQLDQINEARRRAHRQNALINLLPPQLEVCAINLILFFILFLTRNVFLIRFLLIVQKYKQGLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I369</accession>
    <name>A0A183I369_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hamartin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14181</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040649">
        <property type="protein sequence ID" value="VDP15807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I369"/>
    <dbReference type="STRING" id="387005.A0A183I369"/>
    <dbReference type="WBParaSite" id="OFLC_0001418901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001418901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001418901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001418901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="805" mass="92535" checksum="04ADD66457C51414" modified="2016-09-07" version="1">MELCSNIQDFLPQNTLAMLTLLGQLIQKTPSWLPKLAEHSLFDHILKFIRPSENIVVVISAILLISSLLPHFAAPKKSALLNLFRLLIVACNMLYNFKKLFDQHKADIIEGIYVSHLYSAVIQYFIVLYGIYPATLVEYLKNYMNVVDGRAMYVLKALFCAVKFHPSILSATVEQELDRSRWNQREAHDFLADCRHVLVRPILPAIVKASKFISSNHTLETSSSTMSYVSQLPDLNDLFQTDSSSSNSLGASLDHWNEDDAWLECGKSDSDILSESRSGSLDNRVSDIIISFSTESSTRRATTDGADSKHTRRSSLTQKFNDFIRRRKSRTLSDKSLHHNLPLPRSLLVATTDRTITGEPIEEIFVREDIQKRGDETGHIEEGVDAREICSSSIPFPSVQPSEDSFANTPATIVPLENMHQLECETFAPDTFENHELEVFSSANSATSTDVLKNFQQGVDADDNAETIRYRKTNEFKMNETEEPSGSISNDSTNRFSVTSFFRKVNRQRFISGCCPKKNEMIHFFDHLGNFSQTQLRHTLSCPDLLHVSEMNDREKISSLNDLKQRRSMTARNMEFSVEDIEELIAQKCPYLPFLQALPFSLIDEENLNEELKCEHERTRQNYIEASADYHTCLKQLGLADRLPATIYDDISEQLKGLSAETQIKILNVRLALVNQHLLYERCGRLLHAERNRRLFGRLKQQKSLESEKISLNMALHNAQVEREQLINALTDLRKRGYIERLKREEIEKKYCETIKTCRDEADHYLITLTNMKLEMESMVESSSHRQIELEMYKRKYDFVFDRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I497</accession>
    <name>A0A183I497_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14559</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040957">
        <property type="protein sequence ID" value="VDP17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I497"/>
    <dbReference type="STRING" id="387005.A0A183I497"/>
    <dbReference type="WBParaSite" id="OFLC_0001456701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001456701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001456701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001456701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23849" checksum="B2C7B5D57F996546" modified="2016-09-07" version="1">MGRTSWIIWDGELRRGGVKRDRRVIIICVSCMVVPLSYTFGSRGGGGNNNRGGMGGRGGPRSFGGRGSGATSGGRFSSGFGDRKYDFGSRGASGGNSLRPVDWSRENLRPFEKDFYQEHSAVTRREQVEIDKWFTDYQVTVEGNDLPRPVFDFKEAGFPQVITDMLFANFQKPTVIQSISWPIALSGRDMVSIAKTGSGKTFAVFFTFLISAIWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5P5</accession>
    <name>A0A183I5P5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041548">
        <property type="protein sequence ID" value="VDP20205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5P5"/>
    <dbReference type="WBParaSite" id="OFLC_0001506801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001506801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001506801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001506801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34681" checksum="626A2E3DF9D21980" modified="2016-09-07" version="1">MLKSTSIITLVEGEARIPAEIIPQKEEPFNDLEWHSPGSPPPPSSSSRCHIAPTSTPTVAADYRISVAHDVIENTDTRMRGSSLGGPGGTPQVGAMVTIADALDTDLMHPDFEHPNLLADNTGEPLEKRSRHASRDSVGSVNEEVHQLIGGRIVGQPIYIQIKRSEDGTASNRRTLVVQGAVEGTRLVQLKPPFTVSTSNDGQQRLIREDALESGNQSNTVRIVSHLPTGQHGQVHQEEHHTSSETVGRVGSATMSETSLVHRDVSELRPRAESTRESLLVPTSTSRQPNRLAEGYQIRQLSQKRDFANSTVSTGTPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6I7</accession>
    <name>A0A183I6I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ERF1_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15349</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041997">
        <property type="protein sequence ID" value="VDP21456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6I7"/>
    <dbReference type="STRING" id="387005.A0A183I6I7"/>
    <dbReference type="WBParaSite" id="OFLC_0001536001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001536001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001536001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="2">
        <location>
            <begin position="132"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP21456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001536001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29817" checksum="B155694DAE08CE74" modified="2016-09-07" version="1">MHEGLANLCLVTAAMTIVKAKIDMQIPRKKKGFSNQHDKGIQRFYEAIAAAFVRHVDMKIVKCILIASRGFLNEQFLNYLMDYADKHGNKLILESRSKFLLAHASSGFKHALKEVLSDPGIAAALSDTKAQAEVKALNTFYDLMGTDPARAFYGYKHVLMANEQLAIDTLLLSDSLFRSNDINLRKKYVELAESVKEQAIENIRPVLARNMLLQGSNVLIFSSMHVSGEQLSALGGVAAILRFPLHELEDEEMSDSEHDENNSDFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Q7</accession>
    <name>A0A183I6Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS15419</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042103">
        <property type="protein sequence ID" value="VDP21778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Q7"/>
    <dbReference type="STRING" id="387005.A0A183I6Q7"/>
    <dbReference type="WBParaSite" id="OFLC_0001543001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001543001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001543001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP21778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001543001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17523" checksum="8C40EF2FCDCE9FA0" modified="2016-09-07" version="1">MYNRSVAGRQRRTHLLLICVVIVFAVAWLPLNVFHVLNTFGIVEFSVPLFAMCHLIAMGSACLNPVSYAFFNQNFRQQFVMFYDVAVRKILQIFDCIIPARYKRDRMKYNRSTRPVIIMQHTSTIHAQFTGKDDEDEKSDEAKIDLNDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7F6</accession>
    <name>A0A183I7F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042583">
        <property type="protein sequence ID" value="VDP23157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7F6"/>
    <dbReference type="STRING" id="387005.A0A183I7F6"/>
    <dbReference type="WBParaSite" id="OFLC_0001568101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001568101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001568101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001568101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8330" checksum="9B30FF821960A7FC" modified="2016-09-07" version="1">MLNEVLKCYTCASTDYEPLFERFTAFRRSTNIPHFGEFCDSLVQLHAYAPLTKCSSTCVSIMEPQYFGGKCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8A1</accession>
    <name>A0A183I8A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15963</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043385">
        <property type="protein sequence ID" value="VDP25420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8A1"/>
    <dbReference type="WBParaSite" id="OFLC_0001597601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001597601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001597601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001597601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14617" checksum="614706073A1A4908" modified="2016-09-07" version="1">ATATATATAVATAASPPQFLQQPQQQQQQQQQIIQQIQANNCNLNDTTNGYHQDMNESNELDEDSNSHKEVKIEVFSEDENDYDDNGDDNYAVKEIGKIKLENILSRIFSNFPASSDFLFWILKLHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8J5</accession>
    <name>A0A183I8J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043826">
        <property type="protein sequence ID" value="VDP26593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8J5"/>
    <dbReference type="WBParaSite" id="OFLC_0001607001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001607001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001607001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001607001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9867" checksum="16B44365A2E0F51A" modified="2016-09-07" version="1">MHVRITDMRRSSHHHLTSSSVEGGFHSCLPSERQRRREGRSVPLALAGSWFLSHLSPKHSTGHGGSCEVGWGGVGWAACSGPQQFPPLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U1A2</accession>
    <name>A0A3P7U1A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000463">
        <property type="protein sequence ID" value="VDO28166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0S0"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="359" mass="41326" checksum="07E0AD14423F20CF" modified="2026-01-28" version="1">MGEYLFNIDHGYLEGLVRGFKGGILTQSDYANLVQCETLEDLKLHIQSTDYGSFLANEPGSITVQVIDERLKEKLVTEFTHFRNNALEPLSTFLDYITYSYMIDNIILLITGTLHQRPINELISKCHPLGSFEQMEAIHIASTPAELYNAVLVDTPLGEKDQLLVSFAAAYFVDCINEQDLDEMNVEIIRNTLYRSYLEDFYKFCKRLGGKTAEVMSEILAFEADRRAIIITINSFDTELSKDDRAKLYPRCGKLYPEGLAGLSKADDYEQVKQVCEYYSDYRALFEGSGLHPGEKALEDKFLEYEVKLNVLSFLHQFHFGVFYAFIKLKEQEMRNIIWIAECISQRHRAKIDNYIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U4T3</accession>
    <name>A0A3P7U4T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000244">
        <property type="protein sequence ID" value="VDO26639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZK9"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="244" mass="28264" checksum="B89ED2992B778DA6" modified="2026-01-28" version="1">MSYAEKVPSAITRTLENGFLLCIICNTQVKSKLWIAHSNGRKHRENVAKFKNSHLTAARTINSTSTKRNPEESITSLSTLPLKKLKDDVKESTSSESTPWEKDSLSKTAESNTKYSQKKNVIEGVPEGFFEDKKLNSRVIDTIEKQANIEQQYIDFMRELDEAKEEEQHREEDEEHVVAIEHDIAFIDEQIDQWKRVNRLELRRDELYNVVAEKNERHKEPIMMGQISDDDSDVDLTGWRNKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UBG4</accession>
    <name>A0A3P7UBG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001228">
        <property type="protein sequence ID" value="VDO32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF70">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="679" mass="79086" checksum="E03DF18BD10F5A0D" modified="2026-01-28" version="1">MWQSVVVSALFIVLFHAERSIGNLNNYNEKIVFSFINTVAKLNVSQLCGDSLTKIGPYLLDYNTIPAQKEFFITAYTSGDAEQFSSRDQDRWVFRAYKCIQAAGEAPYSKSEHPLNYCFGYNEDSKGKDGVAYGICIPSTCYNDRNKLVDEWQSMISTDATAVDYISCTKSRHDQQWYEKPMAIAEFILHQNFMLLVVIATLYHIKKGKQTGNRWVEFFLAFSAKKNLLKLIQMPKDSQSTITCMFGMRFLSMVWTVIGHSFIFVQAYLDNVEEFKDDMVDHFYNQWITNFTLAVDTFLVLSATLTAFTWFKKIQKDSSETIPTWTSYSYWLRFYRHRIIRLWPAYIYVLVDIGMRVSIQHFHPMWPPTDPAVQCPKHWWENVLFINSLFENRCMPWTWYIGTEFIYYLLSPIFLLLLHQVPRIGFAISLLIILSSNFLNVFGMIHWNFPPTQFLWKQPEIFSADFIKHHVLMYIKPQYRIGPYIVGLLLGYYLVLVQNRVKQTHQRSMRFQALGWTFASVACFWAIFGLYPALQGWDWRMYHLFYGGFHRTVFALSMAWLIYACHTDNGGIINKVLSMKLFIPLSSLCYSVYLVHMVLVVFTYLLVPFPIIYTTKWPIFGHCVVQLMLSYFFGLICALLAELPALNLEKLIFQDGGKNTAVKLAKDYGLQQSKTADIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UNR6</accession>
    <name>A0A3P7UNR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000058">
        <property type="protein sequence ID" value="VDO25014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="395" mass="46457" checksum="F2360DFDFAFD8D0D" modified="2026-01-28" version="1">MRLLGKLQLILITVFLLVCLKLYDFFMISRDVRLETKFIRNTHPKPQFSKLTDNLLIFSSFVDTRNGNMGFPFFRIIAVMRFRHYKYYCVFKNQQTHAQIYAMAENHGRLYGAYILNCRIPDRIIITTVKITLTDGNDKLDIVPTYYITAGSPNSLAAFTYNYTICLPFLYGHFYSAKYIIEMIEMYKVLGVQQITVYTTKRNLYSDVQKVLNYYEAESILDVIDFELPIVDVWNHAQLVFINDCLYRNIGRAKFVSFQDWDEIIIPSRNIDLTSLFQNIFNASIASYQISTMYIHYNPNYPFLINSVQARSERLDKEFTKCVLQPRMVFEQGIHHTSRVIQDHYLTLKLQSSKAVLHHYVKYTDTQTYPVNTIPSRYGKILLRNCDVVLKKIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VZS1</accession>
    <name>A0A3P7VZS1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003488">
        <property type="protein sequence ID" value="VDO40267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VZS1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20426" checksum="A4978A1A6B2F44E1" modified="2019-02-13" version="1">MLNNHSIIFAVFEESEDPASRSFFSEIIASVSDVKFSHNGRYLLTRDYLTAKVWDINMESGPVETYSVHDYLRSKLCTLYENDSIFDKFEVDWSGDDNHILTGSYNNFFRSFKRGVDASVAKTYEKRVLAGTVETQADEDVSADSLDFTKKILHTAWHPKQNIIALAATNRLYIFQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W3I1</accession>
    <name>A0A3P7W3I1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Discoidin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS8383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009429">
        <property type="protein sequence ID" value="VDO55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W3I1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Discoidin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="173" mass="19320" checksum="25085D49D0671684" modified="2019-02-13" version="1" fragment="single">MNFRGLGLLTDGIIATTNPLDDITSSDNAISDWIGWNRLITNGSIEIVFEFADIQKFAYLEIWTYGTSLRTTEIFFSIDGKKFTLASQISSIQRRALDAARNLPIRIPLHNATGQALKMKLNYKEQWLFLSEIYFASSEETALGTVRKATVSTRILTTITDITTTATIITSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W4G1</accession>
    <name>A0A3P7W4G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004084">
        <property type="protein sequence ID" value="VDO41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W4G1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="574"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="574"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="737"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="1039" mass="119245" checksum="94C0A5CDBC3AC5E4" modified="2019-02-13" version="1" fragment="single">MNQRSQKYKDQSTSELSKQWSKNVKANEKICKNDTHANDIIYKNEIHANDVNDVNDGNDIHCLKSEIVKILKEVTGEAVTIDDYQRSFMDLGLDSLKIYRFVNRLTEKIEIKPSLNVLAIFEHPTIEQLSHYIGSLFYRLKEHSEKIITDNNILSKHNENFENMARNFIIFVLYSKDKKKLKEKKRHFLKLFDQSSKIAEILSNQSFVYDQSNGYLHVVWGSKYKMLRNNLLHSEIIPNIEQSRIKPVICFMISGHGSQVWNMGRQLSCIFPFFREKFNETLDIATQYMPEKSVNIRDVIYQWHYCELMYHTEYAQPIIYCFAYSLAKFYEFCGVEATFFVGHSIGEIVACTLAGRITLDDALKLVIRRGKILGLIRGKGKMIAVKKNDAEKLQRYSGMNRAAENSDKQVVLSGDNHSARLCLHFARLYQYPITVIDDCYPFHSSIIDDALLDKYMMECRKVKLQKTKTKNVINNCTGQFMDFGTESIASINSTVFFNRCVETLRNNNTNIWLEIGSGEILSTLVRSMLGSTPNMLICSAIRNNTQEVDAFLHSLCQLQNFGIKIKWNRICNRANIANAQETTKIGREKIEQKLVIETEKFMELIEQHLIHGEITLPAAFIISMFTEFAVNSSAKYTSKSKMKRNTRKESLYKREKSSIECETIIFEALRLERRVNEIDLSKLRIKKFNSSELFLTDNISKYSSCRISNEESKKRLEQMKQIDILNKLRINYEQLKVKMSQLSHEAFYEAMRKRGLQYGPKYQILREIYRKGRYIGATLINANDLTRLLDGALQLLSAALLTDSKSSVYIPFAIDNIVIKYEKIKIVRNCFHAYGIITKRIGNIIKGIVIIYENDNAVIILHNVTAIDISTSKLNRSIKDHKSCDSQYSVGKKMTKNFANKDKSDNVRKDSSTDNKSTGKIKKNQNSSIRCENLEIEIISYAGQFPGSAVDCASLWNNLKAGISFHSSGNIQKLQTDVTIFNPVQFGITPKEAAYVDPQQRILLELAQKTIEKAGLKKLGSKTGVFIGVSSSDFAQKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WPI8</accession>
    <name>A0A3P7WPI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012299">
        <property type="protein sequence ID" value="VDO62961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WPI8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="144" mass="14359" checksum="42C5D3642FEAF96F" modified="2019-02-13" version="1">MEESIRITQPQKAAAYQLQQSQQGTTVGGNCRTSSSSSNSNNTNNTCNSSGSGGGGGGGGGGGSNSSGHSGFSSGLSDKEIPTTSSGVVPGAPDIGYSGCIMYDQHPSLADSYSLVVATSTDNNRSNDGATIGKIDNNIETQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X9V9</accession>
    <name>A0A3P7X9V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000194">
        <property type="protein sequence ID" value="VDO26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5807377at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="315" mass="37014" checksum="5682932F9D04E91D" modified="2026-01-28" version="1">MLSICSLPPEIQLTVLNYCDFFSLLQLRQVSKYYKWLAEYNLCHRKHLDVTGDYLAILRNCKWKSFALLNEQNDYDAVFDKIFTFISHYMPALRDLSLRHCSVVLTMTGLIQLASATPNLYRLDLSQAYNKPSFETDAILALQYFRQLKVLVMDGFVIQKTTDSGCSYRLEMPPFRYMQHLETLVLNCPYDTLARILYSLCETHCILYKLKHISLGVKYSTAKYPELLIWFLLKYRSLCFVHIWNALFATNDQLKRFYAALISLPKLNELYLENCELCDRIDSSIEVQFLKSITLRGIRWNGLVRSMRYDPDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YAB4</accession>
    <name>A0A3P7YAB4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZIP Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011915">
        <property type="protein sequence ID" value="VDO61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YAB4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14856" checksum="59B65C55F85F5373" modified="2019-02-13" version="1">MKAPAAFGLVSFLLVEGVERFRIRRHLTVFSIAAPLAAIITYYLIVIIENDQFSADSATGALMLFSAGTFLYVATVHILPELMGSNVRDYQLISNSAEGSNRGCNESRVSLKFIELIAVIVGAISPTFLISGHSHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YW54</accession>
    <name>A0A3P7YW54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005611">
        <property type="protein sequence ID" value="VDO45408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YW54"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="171" mass="19576" checksum="43D41FB099478D74" modified="2019-02-13" version="1">MQENEIGNSNLSINEPNLPETRNGTNENETTHHERAVDVDGIVSEHRRWRSESRNVLRKIYDPEERVKKTVPLRISSSRNGELSERCKSQMIWKEGTDFIKNWAQLEASDGRKNFSSSSPNVNAVPSLSDQGNTEQIAQNTQYNSGIHHKEKYKWKETLPAAFGPHQVVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AZ85</accession>
    <name>A0A3P8AZ85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041536">
        <property type="protein sequence ID" value="VDP20147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AZ85"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="119" mass="13324" checksum="5BA34B64A7701DFC" modified="2019-02-13" version="1">MNFIFLQGTTSGDVCFHLLLDANAANITDIGFNCKLISTNIVQVDFVNQIIQTISLRFLTDVLMIKDSLKNRVRNRLTASQILAAVIRISDNDNQDNTKYPMLNAILTFRDSGSCSMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXQ8</accession>
    <name>A0A183GXQ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS18</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="UZAJ01000005">
        <property type="protein sequence ID" value="VDO24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXQ8"/>
    <dbReference type="STRING" id="387005.A0A183GXQ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000001701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000001701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000001701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="90"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="208"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000001701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34810" checksum="3BCBC38F7ED01087" modified="2016-09-07" version="1">MSRYPYCNPILTRTQPSDSKSQFTPQISTQKSTTLRGKVLRFRCHGMRFEYALISRRLLFADVNKVLIGFKKIRTMTNANDISFLSQYDAKALDNELFNTYAFSVDQLMELAGLSCAHAIARSYDRGKILVISGPGNNGGDGFVCARHLKLLGFEPFISYPKQSKSELMERLVKQTKKMDIPHLDNSVFKNPSEMKNKFALVVDALFGFSFKPPLKEPFDQIVEAVNKSSLPVVAIDIPSGWDVEKGPLEKQIAFNPDVLISLTAPKLCAKHFHGRAHYVGGRFVPESLAIKYHLKLPEYPGTDCVVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXS5</accession>
    <name>A0A183GXS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS35</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000008">
        <property type="protein sequence ID" value="VDO24286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXS5"/>
    <dbReference type="WBParaSite" id="OFLC_0000003401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000003401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000003401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000003401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="870" mass="101848" checksum="1130D4601FF06C8D" modified="2016-09-07" version="1">MIGFDDILYFNDPNYPWYKQDITHEEFEKAAQPLCNGLVIYAKKNAKYNSLYYAAWVKTKKNIYNDIFLLCCMPCPVAKTEVQWRITLKLQFLIRQQYNLINNYILDEVHAYINDTQPYIIENYYITNRMPEMNASMKMCNAENFKKVPITTNNNVCFVTASDILDRSSLFERQTEQTRDRMAHEIIRLGPYTAAKIGYMKDLQCRIQHTSHEDNECVVWMTYDEYGYECCCYGDLIDICQDRISNSILVGIEQLTAYNEFMACAISKNNNTTYNYKYDKKTRKITLRGKMQDILNGIRIESYCPLYLEILNTEYKYYLSLDEFLTEKSDHSVLTSGMAAGCHYYANWDIRLMDIVKTRCIQLIRKFDIVKRGLILNKINRQKIDYHCKYNSQYQFLFNDLFIIDKSSRSCLLHYIDSITLLDMDSRLPDNDFVLFQQPGCKEAISKECSKHLMKNEEKKDQFSELSFLAHLNYYPASGSAFYPIDFSYALLEDGKCRYIEVEVNLNYTNLQSCQETVMFKTNYMPLKIFACRCRTEVGSRTPCDEKLASEIMNLARSWPLENSTQCIQYNEQKLQDLSLNQMETIFPTHTSYCYTEMTLKKSGNGPKFYVSGGGVTHTIARNAEKHLNHIAYAMWLEAGSVSSLCSKNQKGKALCFCRSYNNHPDACNEDIWQHIKLQKILIMQELHFTVFQKYFEIKTLTIVRNKYEMMDLLLNLIFSYCFHYNLGGSIFNQMEYSFHQIQRYGELQIRKEYLNTLSDHLVQKGETWCHSPEIYGTLDIDMENADVITSGKCVRAKPESKTKTMREFSDDRIFCAELKALENKCIAKVTDTKYLEKNRLICCCKRKCEAVGFIIQSLAKNIADNLEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYE8</accession>
    <name>A0A183GYE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-nucleotidase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS258</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000073">
        <property type="protein sequence ID" value="VDO25163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYE8"/>
    <dbReference type="STRING" id="387005.A0A183GYE8"/>
    <dbReference type="WBParaSite" id="OFLC_0000025701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000025701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000025701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO25163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000025701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="66328" checksum="45422DFFDA4C5B06" modified="2016-09-07" version="1">MIEDGARRTYKRDPAHRIFVNRSLRMEKIRFFGFDMDYTLAVYRSPDLEIVTFDMVVERMISLGYPEELRSFKYKALFPIRGIWFDNVYGNLLKVDGFGNILVGVHGFHYMKPSEIEELYPNKFLHLSENRVYVLNTLFNLPETYLVACIIDFFDSSPNYAPTEDRTGIKSGDIYMSYRSIFQDIRNSVDWVHFESNMKQIILDNKEKYIIKDDRLKQLLLQIRESGKQSFLLTNSDYSYTNGVMEYLLGVGWTSYFNITIVDAKKPKWFAEGTVFRQVDTKTSALKIGSHMGPLEQGQVYAGGSCDAFRRLVKARGKDVLYIGDHIFGDVLRSKKTRGWRTFLVVPELARELTVWTERKPLFEKLKLLDSELADVYKNLDSNSKEKPSIVHIKKKKEEKYLSWNLTFFLSFKMCDRQFQLLTHEMDNEYGMLGSVFRSGSRTTFFASQVERYADLYASSCFNLVHYPLFYFFRAPMTLMPHESTVDHASVLSPTNHVIQKASVGNEVRGLKVDEAPFCHEEEEEEASNSDVELDVGKTDSLSEELTSQQLNSLDVVGIPPGHVDDMSEQIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYM9</accession>
    <name>A0A183GYM9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS339</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000104">
        <property type="protein sequence ID" value="VDO25463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYM9"/>
    <dbReference type="STRING" id="387005.A0A183GYM9"/>
    <dbReference type="WBParaSite" id="OFLC_0000033801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000033801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000033801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000007">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="275"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO25463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000033801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57195" checksum="3104FF5E3308AC9C" modified="2016-09-07" version="1">MVLIGAAIITKTGKPLLARVFISDMTKARLEGLLDAFPKLIASEKSQRQHTFIETDSVRYVFHPLDNVHVVLITTKASNILEDLETLRLFSRVIPEYCRSNDEKEIQANLFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEERVFNQIKIAQERAANELMTQKAMELKKLKAEQRKSGRALGSSATAISSSSVPLTAVIDDTPMRSAVKQAPATTRESSKALKLGSKNTDDDQFLKQLRREGQIVDTSLRVSDTADAGDRTASEIGSSSISRAPVHIKIEEKLSASVSRDGGLESGEVVGSASLLINGPQFATVCVQISNNDKHGAQLQVHPNLDKKEWLQKSLLKLKSVQKPFPVNMDVGVLKWRLLLNSEEMLPISINCWPNENPDGCVVNIEYTLQAENMTLNSVVIIIPLPPATVPVISECEGTYEYVRSRSQLVWNLPVVDESNKIGSLEFSTSNGQANHFFPIAVRFTSTDLFCNMAVESVQKMDIGETIQYSTESHLITEKFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYN6</accession>
    <name>A0A183GYN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS346</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000107">
        <property type="protein sequence ID" value="VDO25481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYN6"/>
    <dbReference type="STRING" id="387005.A0A183GYN6"/>
    <dbReference type="WBParaSite" id="OFLC_0000034501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000034501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000034501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="441"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000034501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="653" mass="72218" checksum="91972EEE314A135A" modified="2016-09-07" version="1">MDEFLEGNHILRLIYMILFMFITCNYSRLPIIGWLPAYNWHEDLWRDVISGIMISIIYIPQGLAYGLMVGIPPIYGIYTGIVGPLIYIFLGTSRHASTGAFAIVAMMVGSVIERSVTESRLINNETDRLCCSEITQKPDAEKAIQLSSLIAFFVGVVQVVLGFLHAGLLAVWLSDQLVEGLAAGAAVHVFASQIQTMTGVRNVPLTSEMFGIIRVIFSIVLCYLATETSLDLHLHIVGDIDAGMRAPFIPDFSETGQIIYSAFSIAIVSFVIHIALAKLTAKEYNYQINEWLALGTMHIVASFFGCFAGGSSLSRTIISAKLGSRSQLTTLVVVIILLIIAFGAAPLFKYLPKTILSCIVVVAMKELYTKICWSRMLFRESTVDFFIFLVTFTGVVLININIGLAIGIVFALLTVVLRSQWAESTCMGRIPGTSDFKGIGHYRTAMEISGIKVFRFDAPLYFANAELFLSSMHSATGLDPLNIVAKLKQTVDEKKKDDSIVKKNEVVDRDEEIQLTVRRHSIQPSKRDVEVNKEAEDLIQLTHIIVDCSSFPYIDLMGVDALARAHAEYKAINITVFFACCKVAVRQMFEYSNFYDHVPKSYMFVSLQDAVAQAQYEQQQDTRVGGSAEAVPSKIMLPSINPDATQSSSAGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYS4</accession>
    <name>A0A183GYS4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">OFLC_LOCUS384</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000121">
        <property type="protein sequence ID" value="VDO25603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYS4"/>
    <dbReference type="STRING" id="387005.A0A183GYS4"/>
    <dbReference type="WBParaSite" id="OFLC_0000038301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000038301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000038301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055163">
        <property type="entry name" value="ALK/LTK-like_GRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF604">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12810">
        <property type="entry name" value="ALK_LTK_GRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="21">
        <location>
            <begin position="239"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="898"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1190"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDO25603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000038301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135820" checksum="2764A653B5211B0B" modified="2016-09-07" version="1">MLCDFESKCDWMFESPARKYPRDPRHNFKIIVGNRNSKPTHYAYFNFTKTREEPAMIISPYYQHLSIQCELRFMYRLFGDPDATLMVTSQHRALSETANYIDAYDYEDETEWTRPTLHSTLKEQNNYIDSWKEVSVHIGHVTHPTRIRIECHSKGSNAIAVPSGNTECYIDNIEMVKCDEEVWYENICQSNKTKKYLCHKYDRPKCIDYDQLCDMTVDCPGAEDEQTDLHNCTSIPIGARCTFEDDNEGKTGCLGWRLETYYVHNNRRADENKHLFIRVNSNEAAKQSSLKHVPSRDHTFEHSNNSGHFLYFTSEDSQERNSFTDTKSTYLISPHFPPTVNVPLNPTVRSFNSCRIRFYYCSYGSAISTLQLTIHPTNGQPAKIIWTPPTHSFADHSYYCEWIKVSIDLPEQKSEYFLKMGVSRIFDSSISFAIDDFSMTPDCFANEETWRSQYVPYVYNITSCGQRGASQPTSENCESFYNHSATKAVLQNNTSNGFQKWIVPKTAEYRIEAYGASGGHLMQQTINNYGGQVITVLNLTVAMELNILVGQMGESPCDHFNSSTDSLNNHQHEILKYLCKKDDSIWNDDTAMANAIMFPGTAGGGATIVKYKNTIILVAGGGGGIFPEQIVQLEKPGVNPKGGYSFEADKNLRSKDLHNPKRGNLWMSGDGVHLVYNSRKEKFVVGGELNNTSSFGSICPLLSMWKILGGFGGGGASCGPGGGGGAGYHGGEGGQKYHGSGGKSFAQYKDAIIRAGINSGNGYVLIHPCRLHCSSNATCRFRLDNAEKVSSYCACPDGQVVGELQECSVFENKKQISVHRKEFLLVILVFAFVFCTIILLSIYFRRRLKKAKMEKAELNREIGMCALTPSTPMSISGNPIYEPFGPCAELQPIPRVNVTLIRPLGQGAFGEVYEGTLMCGNQLVQVAVKTLPKSASKQAVNDFEMEALIMSKFRHENICELMGVCFDVTPRLIILELLAGGDLKSFLRECRPKNNPLMQSMPLPVIIHRLSQSQSAPNNSSLPDSPSSVTETISQNTYSQSTINTILNSYTEAVPSNDCDPLPTKGDGVNFNVCTPYQSQSSEPFCVLDGTTQSLWANDQVLSGSTETGISISAEPASNCNGHVLSTMALHDAVAGSRKPVVDTDSSNNRLIGSEYANAIRTEAVSLLERRYPPPMKLRVLTSPISTDFSSPNVISSSRSSNPLNDQSLLQNYMNQSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0H8</accession>
    <name>A0A183H0H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotran_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS988</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000409">
        <property type="protein sequence ID" value="VDO27809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0H8"/>
    <dbReference type="STRING" id="387005.A0A183H0H8"/>
    <dbReference type="WBParaSite" id="OFLC_0000098701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000098701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000098701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="4">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000098701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34626" checksum="3CAEB520DEA3FB19" modified="2016-09-07" version="1">MHKSCGIVFNEGITAIKNVIISIDQTLLEIKPWKLIVGTAASVILFQYVRRIWRASERPIYSRFRSKVFSAICLLPPIRKKLEKELGDARQKIFHEIHKCDNTGLFIRILPENGLDNAEIISIAEEYNAMTDIDIAAGKVSGAIYNDQNSKQNDLLSKIFDIYAFSNPLHPDIFPGCRKMEAEIVRIVANLFHGRLECCGTVTSGGTESIVLAMLSYRNYANAKGISEPEILVPVTAHAAFDKAAHLFGMRIRHVPVGNNQKVDIDRMKRAISSDTCVLVGSAPNFPTGTMDDIEQIAQVYSIMRNFLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1P1</accession>
    <name>A0A183H1P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GRASP55/65 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1401</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GORASP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000651">
        <property type="protein sequence ID" value="VDO29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1P1"/>
    <dbReference type="STRING" id="387005.A0A183H1P1"/>
    <dbReference type="WBParaSite" id="OFLC_0000140001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000140001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000140001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000056">
        <property type="entry name" value="Golgi reassembly-stacking protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="449"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000140001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="612" mass="66118" checksum="352CE846EBDF2154" modified="2016-09-07" version="1">MPKALTETLAAQYRDKSEFRAVFGMNVVCTVTSLKMCYGMFGVHRSAVECKLIVAVSMGNSGSRNIPGGGTEGYHVLRVQDNSPGQAAGLEPFFDFIVCIGNTRLDTDNDTLKDILKQHVERSLELTVYNSKTQTVRQTQITPSQMWGGQGLLGISIRFCSFEGARENVWHVVQVQPNSPAEIAGLQSNLDYILGAESVLNQADDLIAHLQANEGKPIKLYVYNTESDSVREVSLTPNSAWGGEGCLGCDIGYGYLHRIPGDRRGPLKGEEIAVMLKQQLNGTNSSDAVPFINNDNSCYSGSSAISNNVINIPQPGSTGIPQIDSIQAITKFPDPSSFITPILRQSTESTDTSVANASQINGPYPTRVCSGKFSAPVQSITVREQPLTSSNPEMSIIPPPSTAFPAVELSTLPGTIEQPFSAQNNNASYTNANPEFQLQQQNFMPNSVDAEQCGGTPETISQQSYYPSQQQQYMHDPQYPPQPPIYNPSSSLPQPPVVGVVPQMFSNLPRQQQQQGSSYGPLPPQISASSASPFTSSSQFSGLNFPMPPLSTMGITQLAHPPTTISFGLSNSPFGQQQQSDMSMSAYSTPEPTFKSDFQMAGNNQFGLPPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2K0</accession>
    <name>A0A183H2K0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1710</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01000860">
        <property type="protein sequence ID" value="VDO30526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2K0"/>
    <dbReference type="STRING" id="387005.A0A183H2K0"/>
    <dbReference type="WBParaSite" id="OFLC_0000170901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000170901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000170901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="5">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO30526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000170901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26707" checksum="14FC08E0999B57BA" modified="2016-09-07" version="1">MVRYLDMQLSNLPLLPLSDFIFSREYRKSYAESAIVASKLIAEKRKAICPRNEPEVGERVPYIIVSGEPNSTLISCVREPEEFILDRRLKINFEYYVRRQVLPSLHRALDFVPLKIEWRCPTTVGCYKKESNFSCKALGTQLWCRKCINDPKALLLAMCDYHRERRLLAQLNNKCRNCLSLRSVNIDYNKCINMACIVKQKRIFLDCSVTELAIKNHFLTGDKSLQQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2M7</accession>
    <name>A0A183H2M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1737</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000874">
        <property type="protein sequence ID" value="VDO30606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2M7"/>
    <dbReference type="STRING" id="387005.A0A183H2M7"/>
    <dbReference type="WBParaSite" id="OFLC_0000173601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000173601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000173601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000173601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19984" checksum="824E162216CA37D0" modified="2016-09-07" version="1">MNYFCDIVFLPRWTMFDILKKVRDVATTRSCEAVVNACGRAVAAVLTSKPEKVEVISASKLKIFKKCDDSYTFTLYVDKPKDGTYYVVYLPRALKIWRTRQRDEAELLKDQLNNLKFLVNILEKVNSKLFAAELEQLRDSVIRNPYFNDIHHAAACNFPTVIVDLCKSRPKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Q1</accession>
    <name>A0A183H2Q1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1761</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000891">
        <property type="protein sequence ID" value="VDO30692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Q1"/>
    <dbReference type="STRING" id="387005.A0A183H2Q1"/>
    <dbReference type="WBParaSite" id="OFLC_0000176001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000176001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000176001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO30692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000176001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29863" checksum="48F4612667030BCB" modified="2016-09-07" version="1">MVIDAWEMVLQLMHEGEIDAIKSEHRFAYGSVGDPERNIPPYQTMEYEIELICIADGPLYTTLRTNELVKHIMELKERGNYFYNRKELEKAIYVYKRSTELIDMPPEDETLRSLFSVIYSNLSVCYAKLCDWKLTLDASSDALNLNAGNTKALFRRANAYANLNLIEEAIDTLNIAHEIDPNDELIVKELRRLKARLKLCREQERSLYKRMLAGAQVDNERRIYSIHRLRYLLLAFFIVVFALFIHFLRIVMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2X0</accession>
    <name>A0A183H2X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP synthase subunit s, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000942">
        <property type="protein sequence ID" value="VDO30932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2X0"/>
    <dbReference type="STRING" id="387005.A0A183H2X0"/>
    <dbReference type="WBParaSite" id="OFLC_0000182901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000182901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000182901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000182901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24487" checksum="C76B6C9A4CB8DF03" modified="2016-09-07" version="1">MYFGPELACLEWLMECGSTEVIMSDGTSITCRADMRRYISDFGFNFGSIPFPMVPFKWSPVLPTISMEKLDAIYDMRWAKKPDVYIVKVDATDSAIGDTGFQYFKECRQIEILKLNFCDFFTDKAIEHLISGRPSRTLRNIEIVANPYISDDFIRGIKRIRGLQRAHFYFLPCVAQQAGAVQSLKASLPNCRISFPELKEVGYGYGYTAENSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3H9</accession>
    <name>A0A183H3H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH_dom_type_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001097">
        <property type="protein sequence ID" value="VDO31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3H9"/>
    <dbReference type="STRING" id="387005.A0A183H3H9"/>
    <dbReference type="WBParaSite" id="OFLC_0000203801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000203801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000203801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000203801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22939" checksum="D73EAAAA32A9B938" modified="2016-09-07" version="1">MYSRIHFFPVTVPYDQSIKWPPIRVQMSGGITIIVQRLEQQYKITVQHIMERKPDICVYVNALAHERDIRTCVREVNTQLNHVGVAGPNLEVRENISFKYVSESSMKKKQVSGRIKAIKVTFESTVGALHTNSKLFARSIILKAQHIFIKPEALFTCSKLRVCLLREISYYMKFICLLTYLEFSSNQEFYLYFQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3L4</accession>
    <name>A0A183H3L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001119">
        <property type="protein sequence ID" value="VDO31775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3L4"/>
    <dbReference type="STRING" id="387005.A0A183H3L4"/>
    <dbReference type="WBParaSite" id="OFLC_0000207301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000207301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000207301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000207301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15841" checksum="F787861AB41E08A8" modified="2016-09-07" version="1">MLYDSGDNDNDVAVQKFGLCVDLLARVNTVSMNKTSSIAKRASLGTSTKCNNLMSWLKQKEPSLENKTTTKISFVEKKNTLESGKEDIVPAPQSSAEYLRSLVEDTGWRKVLLVEFRKEYMNKIVKFLQKEKEKVIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H479</accession>
    <name>A0A183H479_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2289</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001284">
        <property type="protein sequence ID" value="VDO32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H479"/>
    <dbReference type="STRING" id="387005.A0A183H479"/>
    <dbReference type="WBParaSite" id="OFLC_0000228801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000228801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000228801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552377" evidence="2">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000228801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19398" checksum="E5592C711D45E98D" modified="2016-09-07" version="1">MRWLSVKYPARMPLIVLCVITHAICVNGKLKGRICAYGDMDRDLYTDIIVQDYDRLKTYFQNENGEFSEAGQDISLGSSHTVSCAVGDFNGDSVPDILVSRKNSSGEKGYESTVYIFSYNAYKPIPLNATLLDELAVMDVNGDGISDVVGFLNNTSLFCQLGSATGNFSSCEHFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4B8</accession>
    <name>A0A183H4B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2328</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001315">
        <property type="protein sequence ID" value="VDO32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4B8"/>
    <dbReference type="STRING" id="387005.A0A183H4B8"/>
    <dbReference type="WBParaSite" id="OFLC_0000232701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000232701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000232701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000232701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12059" checksum="8AC72D8178E714E0" modified="2016-09-07" version="1">MTSLIDSGYRYTRLNDLPSSSTEFFADTLQKQQIILTDQDRDLEKVGDSVHLLKNMSSRIGTELEEQSIMLDDLSTDMERTGMKLDGMIKKIAKVTNMNDGLFESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Q9</accession>
    <name>A0A183H4Q9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001423">
        <property type="protein sequence ID" value="VDO33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Q9"/>
    <dbReference type="STRING" id="387005.A0A183H4Q9"/>
    <dbReference type="WBParaSite" id="OFLC_0000246801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000246801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000246801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000246801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50027" checksum="C015540C20145954" modified="2016-09-07" version="1">MSFLACVDICQYCRCDQHSYTVTCTGHNILLRSVIAPNWAKSLYFHHMSMRHLPHFVHAENVKILRINFCGLTHIHSLSLISLPNLEILHLADNLLADLPSECFFELIKLRVVNLARNLIRDLNLISEMLPRSHILEQFTIDGNPIQISSVHTQLPLARQLHFSDINMEKINDSTIIFLPSIRCNTSETLCRSMHISNQQWFILRTLDLSSQEELEIHPSLLQVVSNVTILNLGTTKLPDSFPNWLQISSHVRHLSIPFTVLPNTNHSWEWCGEHLEWLDISHTNLRTLIIPRNCKIRYLKANDNHLDKVLLRATSLEVLFLERNDLSSWILPPSGTTFNHMLTLSLSSNKIRYLPENALAHYPQLQYLDISQNVLANLSNQSFPPIGMQIRSINMSHNKLSRFVHPILPSLQFLDLSNNALESLDPYLLAGLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H531</accession>
    <name>A0A183H531_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2591</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001518">
        <property type="protein sequence ID" value="VDO33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H531"/>
    <dbReference type="WBParaSite" id="OFLC_0000259001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000259001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000259001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000259001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12480" checksum="989210DD4AB26C5E" modified="2016-09-07" version="1">MNTTTSIIYKRGSEGKPRIGRGRSRGGRYQTTLLILVYFWGCIGPKMRSGGGSGNDQSRKTTGSVCNVVKRDDTTVVVRSCSSTTAAAAAAAAASEGPKWVHRDDKVIKFPAVLINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N4</accession>
    <name>A0A183H5N4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001698">
        <property type="protein sequence ID" value="VDO34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N4"/>
    <dbReference type="STRING" id="387005.A0A183H5N4"/>
    <dbReference type="WBParaSite" id="OFLC_0000279301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23601" checksum="8F176A54078F617E" modified="2016-09-07" version="1">MKKDKKCKSYSFRREKTRRRTSSDTSSETTCCMILNSNKQHSRRSSTVSCISTASSSRSLPRRKKATQSDFLSSIDLCSKEFRYSCCSWKKSKSIAFYIDNREEMVHHMFASLHRRELYELLPENLKNLEIAELRYLCIKELNEMSTKNIRTILRGKDFAGSSESEGEKDAAQMIKSNIKTSKTEIAVADSTTEMTAPNSINLPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Q1</accession>
    <name>A0A183H8Q1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3863</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002731">
        <property type="protein sequence ID" value="VDO38014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Q1"/>
    <dbReference type="STRING" id="387005.A0A183H8Q1"/>
    <dbReference type="WBParaSite" id="OFLC_0000386201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000386201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000386201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000386201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35089" checksum="A53FA4E16ABECDCE" modified="2016-09-07" version="1">MDYRIIRERDENRNQKILFFLKHIAFRFNGTLVLAEHTGDKLNPITLSAVSAASKLGEISVLVAGTNVTKIAEQVAKVEQVKRVFIADHEKLKHQLPEYVAKAVETLQKQYKFDHVVAGASTFGRDVLPRVAAQFDASPVTDIIAIHSDDTFSRPTYAGNAICKVKSNAPVKFLTFRGTAFKSAKESGGSGKIEKAPETDFSFDGVEFLSQELLKSERPDLQSAKVVVSGGRAIGSADNFKMIYELADKLKAAVGASRAAVDAGYVSNELQIGQTGKVVAPELYIAIGISGAIQHTAGMKDSKVIVAINKDPDAPIFEVIIVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H964</accession>
    <name>A0A183H964_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase family M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4026</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002906">
        <property type="protein sequence ID" value="VDO38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H964"/>
    <dbReference type="STRING" id="387005.A0A183H964"/>
    <dbReference type="WBParaSite" id="OFLC_0000402501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000402501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000402501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000402501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="46524" checksum="214F20E03E3FB54F" modified="2016-09-07" version="1">MSSNLRKPTVQMDWNKYFRGVIPSDLHWYLDGNPVVNIIEVEFLKQLDELLKATPKRTLANYMIWRYTSMWNFQLDERYDDIHQEFLRTAIGKQMKSPRWKICSQIAVNQMNHASGALYVKYFFKEADKQVALEMVNLLKNAFKEMLEEYNWLHESTRQKALKKLDEMLTLIGYPEFIRRAKDLDEYYKLLHIYPNDTFVQIMTETSRWSVENSYRKLVEPVQRTEFSAAASIVNAFYSPLKNAIVFPAAILQAPFFDRIFPKAINFGNIGSVIGHEMIHGFDDRGSQFDYQGNLHDWWDDETKANFKERKNCFMEEYNNYTVPDTNLFINGMLTLNENIADNGGIKVAFRAYRNYIKQIGHEEERLPGLEHLDMDQIFFLSSAQVNFTPALHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H985</accession>
    <name>A0A183H985_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4047</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002927">
        <property type="protein sequence ID" value="VDO38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H985"/>
    <dbReference type="STRING" id="387005.A0A183H985"/>
    <dbReference type="WBParaSite" id="OFLC_0000404601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000404601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000404601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="265"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000404601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52245" checksum="F7E8FF2994CC1ED2" modified="2016-09-07" version="1">MLQQRRLNVEKQGKRSTIDDDDDEVENEDSFVERERMSAVIPAYHTYADIDQLELESVYLIEIYAIVDSSDGELHGEKAILYLKTGAINVSQDTHTDSSIINNSNYITTTTIQSRDWESESRNSGLRDDYDNDLSDIRADMKVVTLDVRAPYFDDNNLKTVVSWFRNGLCNGTRVQYMIRWRLLMCQTKDNKRITYDLDSSGEDWEQMKVQECVAVLEDLDFACSYNVELINITTRQIVAKAYFETQSCEKTPSTIPLTCDDQSISQSLSCIVNSRNNSVQCNWKNTNSTEKNVGYRIVLSGSDLEDNQIVIMPPQSIKVQFDKLKSDHDYLIHVQTITSNGLGNTLTTSFRINRNKTLEKFSSVFPPDSQRNNTLPHISSIIMDPNDDQISRNIDLQSIMKDDDEFLYKNERFPGATVLELPLESISSSIFTRTALYFICIDRLLRYLFIVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H986</accession>
    <name>A0A183H986_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4049</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002929">
        <property type="protein sequence ID" value="VDO38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H986"/>
    <dbReference type="STRING" id="387005.A0A183H986"/>
    <dbReference type="WBParaSite" id="OFLC_0000404701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000404701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000404701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000404701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15371" checksum="BA21A5F33CD07550" modified="2016-09-07" version="1">MACAKLHQQILISLKFVLQYILCVLFRDLPRMITLRRKSITDQVVAITGGASGIGKGLAQKIALEESAIVCILDIDQEEGMRTVSEIIKNGGRAYFFLCDVAKSNEVKLCAQQIFNNTKIGVSVSLKTDIYTCTLFLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9D3</accession>
    <name>A0A183H9D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 tensin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4095</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002984">
        <property type="protein sequence ID" value="VDO38864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9D3"/>
    <dbReference type="STRING" id="387005.A0A183H9D3"/>
    <dbReference type="WBParaSite" id="OFLC_0000409401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000409401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000409401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 tensin-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000409401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27747" checksum="66532DF0BDC2801B" modified="2016-09-07" version="1">MAKFACIFNLSKKRSDLGRLHSVVELGWPEELAPPLDRLCSICKLLENWLSANARNVVVIHCKGGCSRAAIVIAAYMHYISICSTNEIIENRFALQQFSEHYLGPNGQPSHKRYVKYFSSLLCGRTKIQPATVYLHNIILTNFFGRNVLFKIYERMQPVHTTSLKVTTESNTFDLDDLPLRGDILVKCFQRTNTAERALFFRCQFNTCTFDLSAHNENIYRLRFHREELDNIFDVLKFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9X7</accession>
    <name>A0A183H9X7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS4289</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 13"/>
    <dbReference type="EMBL" id="UZAJ01003193">
        <property type="protein sequence ID" value="VDO39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9X7"/>
    <dbReference type="STRING" id="387005.A0A183H9X7"/>
    <dbReference type="WBParaSite" id="OFLC_0000428801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000428801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000428801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000428801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="587" mass="67571" checksum="92D90164B2552C90" modified="2016-09-07" version="1">MHRNESPIFQDWLEFVIFPEEVILNEPVERWPLCDCLISFHATDFPLHKAIEYERLRHPYVINDLYRQYDLLDRRKVFRALACAGIEHPRHGVLLRNEEGEVGKFIFKLLYHSCVLLLISSSLSFMFQGTLKEFSDHIEVNGMVFNKPFVEKPLSAEDHNVYIYYPSSVGGGSQRLFRKINNRSSWYSPVSTVRREGSYIYEDFIPADGTDVKVYAVGPYYAHAEARKAPGLDGKVERDSHGKEVRYPVILSSKEKLIARKVVMAFGQTVCGFDLLRANGKSFVCDVNGFSFVKTSTKYYEDTAKILGNTILRRLASSMSIPWQIPYQDDDPPLVSTPSGKIMELRCVIAIIRHGDRTPKQKMKIVVTDQRFFDLFKKYNGFNKNEIKMKRPNQLMEVLELAREILHEQQVKILLLGDFTSLVHRNESLKEMESCEDNGGSSSKLERDLEQCEEAIEKWDQVRTVLEMYGHFSGINRKVQLKYLKPREIKNSDDEEMHQQSALLLILKWGGELTTAGNLQAEALGKLFRTLYPGIRRADGKSCPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQMTAAAFAKIRHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAG0</accession>
    <name>A0A183HAG0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LTV1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4473</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003409">
        <property type="protein sequence ID" value="VDO40103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAG0"/>
    <dbReference type="STRING" id="387005.A0A183HAG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000447101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000447101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000447101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO40103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000447101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15011" checksum="694B4CAE11359C75" modified="2016-09-07" version="1">MEKIAIVCPNKKKAKWDCETIISAYSNIYNRPALIVDSSRKQKLKPILRQIEKMDCSIQPTTKSVVSKASSATIRKRGETTEERKTRKAAIKAVRAERRIEKKYNKLTFKEERKKAGACCHNSVIKMMPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAM2</accession>
    <name>A0A183HAM2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS4534</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01003478">
        <property type="protein sequence ID" value="VDO40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAM2"/>
    <dbReference type="STRING" id="387005.A0A183HAM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000453301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000453301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000453301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14211">
        <property type="entry name" value="STKc_HIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="61"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO40253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000453301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45216" checksum="D9F72D9D3CB33BF9" modified="2016-09-07" version="1">MFQVDVPVQVVNSLPGNKTGIKTNNNKQFNNKTSARTKPSTEGEYQLIKNEVLVSPYRNQYEVLEFLGKGTFGQVVKAWKKGTNEIVAIKILKKHPSYARQGQIEVSILSRLSNENAEEFNFVRAYECFQHKHHTCLVFEMLEQNLYDFLKQNKFNPLPLSSIRPIVQQVLTALLKLKHLGLIHADLKPENIMLVDPSNQPFRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFREAIDMWSLGCVIAELYLGWPLYPGSSEFDQIRYIVQTQGPPPLQMLSTAAKTHPPYWRLKTPEEHEQETSSKSKETRKYVFNNLDDVSQVNIPTDLDDVDKECEQLDRADFVNILKKMLSIDQDKRITPAEGLQHPFVTMGHVFVYGPTKYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAP2</accession>
    <name>A0A183HAP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4554</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003505">
        <property type="protein sequence ID" value="VDO40311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000455301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000455301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000455301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000455301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="5880546D9452DE36" modified="2016-09-07" version="1">MCPNSWNRVYESFEKSCLNLFSGWIVLIMIKKIIIVIIINASGNDGESYSNSNSNSNDNNSNCADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAS9</accession>
    <name>A0A183HAS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphylatoxin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4591</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003555">
        <property type="protein sequence ID" value="VDO40428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAS9"/>
    <dbReference type="STRING" id="387005.A0A183HAS9"/>
    <dbReference type="WBParaSite" id="OFLC_0000459001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000459001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000459001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01177">
        <property type="entry name" value="ANAPHYLATOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Anaphylatoxin-like" evidence="4">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000459001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20018" checksum="1FA4AFC50057B4F2" modified="2016-09-07" version="1">MFDYTLIDANELLHCCTSGKRHFEQSSSCTEIKLNETTNTCILTASICCMDILLEQSCSYGIKMGKKDDHCASNIDQVGGGIRKECCECCLLAKELLRTDKSCAAPSGFGALCLRSFHQCCSEDAGSKVDVQHQGNSDLVDLLSVRERCTSAKCEHLCTDRGGTAVECSCHPGYELAPDGYSCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW9</accession>
    <name>A0A183HAW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4631</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003614">
        <property type="protein sequence ID" value="VDO40567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW9"/>
    <dbReference type="STRING" id="387005.A0A183HAW9"/>
    <dbReference type="WBParaSite" id="OFLC_0000463001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000463001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000463001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="98"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000463001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33276" checksum="6DEE3549587FD32D" modified="2016-09-07" version="1">MKQLTGNERFDSIRRGWELLAIFLAFFSPSNPEITRKLTEFIEANSDRLLDMPEVPVSHYAIQCSRRLVRLSATRPKPSLSLIQESRVHIFNPPQFCTPLEELMEMQAEKYPERILPWLETTLIDLILSADGQHTEGLFRVPADPDHVHTARLRLDRGLIPVVRDAHVPAALLKLWLRSLPEPLLPDTFYLRCLAVCDQPEEACRIPELLPAVNRLVLAKLLELLQLLAEEETVKYTKMDVCNLAMVMAPNVLRCGSDDPRIIFDNARREMAFLKTLILHYDTSFIRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB07</accession>
    <name>A0A183HB07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA_edit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003662">
        <property type="protein sequence ID" value="VDO40689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB07"/>
    <dbReference type="STRING" id="387005.A0A183HB07"/>
    <dbReference type="WBParaSite" id="OFLC_0000466801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000466801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000466801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000466801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13551" checksum="6B57CD9223E0E362" modified="2016-09-07" version="1">MATITIKQGIDPELQLSRDTQILLVGKKKLLKNVKFDDDVATKFSGFVTSKTWDSLMETLTENSPSTIPLHLNLATVIAVADEPSRHNAPSNALSIFKEVKKISSADGIKVRSPYLYFHNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDD6</accession>
    <name>A0A183HDD6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5498</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004758">
        <property type="protein sequence ID" value="VDO43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDD6"/>
    <dbReference type="STRING" id="387005.A0A183HDD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000549701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000549701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000549701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000549701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23494" checksum="F8AE2B113A6C3EDE" modified="2016-09-07" version="1">MIKDNEKNKKDKLILGGNLFPLLGSDEKELLSYIESYTPKIIPMETFLEPFLLDYIPAVGDVDTFIKVPRPDKVEDDLGLAVLDEPALEQSDPTILNMKIRNELKDSKNTSAKDVPVKKLERADENIEEIEHWISNIVIYAKPMPNIEHLMQEWPTEVENLLKNELFPKKKSIDHQIQMIFYNIGYNLHPDTCPQTGYKRNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEN2</accession>
    <name>A0A183HEN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Salivary secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5944</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005387">
        <property type="protein sequence ID" value="VDO44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEN2"/>
    <dbReference type="WBParaSite" id="OFLC_0000594301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000594301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000594301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552507" evidence="1">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000594301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15738" checksum="898966C87428742E" modified="2016-09-07" version="1">KIVLGIVLVCALCVANPNACKNPAWYTRFCLLLQELHPEHLYRTSASPNMNDAAFSTSECTADNTTYRLRIKNRAAIAMLMPAVHLMHHIWNGVAWVTEDISGEEKVTNYQIVCHFRLIPRKNGDFWKKVLQIKISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFN3</accession>
    <name>A0A183HFN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005898">
        <property type="protein sequence ID" value="VDO46062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFN3"/>
    <dbReference type="STRING" id="387005.A0A183HFN3"/>
    <dbReference type="WBParaSite" id="OFLC_0000629401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000629401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000629401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000629401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26591" checksum="F5116EC4E9BDEC36" modified="2016-09-07" version="1">MKEFRQILDDLERRVFQLVSRSGLEFTEVKTKALATSPTSMPHWICKPYYRPVRNDSSISDSLYRERRRAELDALAQKTGLSKRQLRKREKRKVSNHQYIHNQAELQIEDRKEQCKNQAYSKCLRCDLPASQDCTFVYCRNCCRFKAATERKDCKSLLLLFLFYTKNFDFFFEGLYDFGNVFSTIDKAFEISAHNFHFATKIPWCYREHDGTTAIVTTLISGIMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFY2</accession>
    <name>A0A183HFY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6396</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006050">
        <property type="protein sequence ID" value="VDO46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFY2"/>
    <dbReference type="STRING" id="387005.A0A183HFY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000639301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000639301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000639301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000639301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28131" checksum="6C91CD4A8CE8F843" modified="2016-09-07" version="1">MHEKTKHADMLQSLKNEVFELSEKNKKFKEILVKTEVLMKNLSKDAKTTMLILEQAEGPGNLEEEFKQACFSFFFDYLKFRTFILLCNKYVQLSALLTTVQENSAKLQTGALESGNFEDLRKVIENLNNELHQCKAENKNLMNQKNNAEWQLGEQREWLRNANNRIAVLEDELIRMEDAKERAHEVLRLENEALNQTFVFLYFRKFLLYIGNNNLQLVSKNFGINRFSVQIFVPIAKVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGW9</accession>
    <name>A0A183HGW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6734</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006582">
        <property type="protein sequence ID" value="VDO47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGW9"/>
    <dbReference type="STRING" id="387005.A0A183HGW9"/>
    <dbReference type="WBParaSite" id="OFLC_0000673001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000673001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000673001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000673001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12224" checksum="BEC4621D5C97D203" modified="2016-09-07" version="1">MPGSCSQPDVVLMSADGSDDKGLVERNYHLCPPRQFQSASHKLVYKRLSSSAAEVQIPHSDDDEKYSLNAFHSGGLLESTHSLTYLEWVHERQTRRMRTRSEWLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH18</accession>
    <name>A0A183HH18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DRIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006647">
        <property type="protein sequence ID" value="VDO47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH18"/>
    <dbReference type="STRING" id="387005.A0A183HH18"/>
    <dbReference type="WBParaSite" id="OFLC_0000677901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000677901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000677901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000677901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34250" checksum="72D87A29BF5BA5D3" modified="2016-09-07" version="1">MYDSVFYVCQNRVFESDEINSFLMYIVVPQCIHHDDGSPKIPYNLLRLFLSWTSTPKLFYLLRLEVPLVSGNAQHSMLSILCSMLSSKSISKLMKEKIIDGVLNLLTLADETVPDPVAEISLTELPKISGLNSGTSMILSELPKLLAYIFDSLPLQDEKHKLNMKHLEVLSRISEFIQDEEMIRRYVSILLTFLESGILRSDDTVQSLLLTVLRMVVATTDAVQFLKNLIHVQSLLKERSHRETLQKIEEAIVMKLKESDKRKAELLSYVASLDAWDKRRIDEPDFDKRHNAYSNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH51</accession>
    <name>A0A183HH51_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6813</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01006699">
        <property type="protein sequence ID" value="VDO47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH51"/>
    <dbReference type="STRING" id="387005.A0A183HH51"/>
    <dbReference type="WBParaSite" id="OFLC_0000681201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000681201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000681201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000681201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16479" checksum="91686BB4D9697876" modified="2016-09-07" version="1">MSKKDRRRVFFDVTIDGSLAGRIVMELYNDIAPRTCNNFLMLCTGMAGIGKISGKPLHYKGSTFHRVIKNFMIQGGDFTKGDGTGGESIYGGMFDDEEFVMKHDEPFLVSMANKGPNTNGSQFFITTAPAPHLNNIHVVFGKVSNLRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI37</accession>
    <name>A0A183HI37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cation_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7147</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007261">
        <property type="protein sequence ID" value="VDO49541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI37"/>
    <dbReference type="STRING" id="387005.A0A183HI37"/>
    <dbReference type="WBParaSite" id="OFLC_0000714801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000714801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000714801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000064">
        <property type="entry name" value="Cation transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF5">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO49541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000714801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29580" checksum="0F3194E5543FAD0E" modified="2016-09-07" version="1">MQGKKGSSDIAKQTADIILTDDNFASIVKGIEEGRLLFDNLRLSIAYTLAHLWPEIFPIVLQFTLGLPLGLSALQILSIDLASELPPSISLAYQLPENDIMRIPPRHRNDRLVSRPLLIYSYAFIGTIITAGCIISFLFVYQYHNVELTDLFFTADNYWCREAENYTISNGNVLTPSEQINIKGQAAAAWQITLVVSQVFHLYMCTTRGASFFRHPTANLVSIFAVVIEILLLNLFIYTPFAQFFLETQSPPNEVDFSFFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIK0</accession>
    <name>A0A183HIK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007540">
        <property type="protein sequence ID" value="VDO50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000731101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000731101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000731101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000731101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15364" checksum="397B14F87831C670" modified="2016-09-07" version="1">METNKGEPDWSMEDVDCVLHWIAGGTISERKGTELLNVIFGKSLSRYTVRSKVKALKEKERICTTTNIEPKESDDNDNESQYRIVVVESENGDVKTYTELMNYSASFSDAAYENGDTLWSTDVYDLSTKEEIDVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ53</accession>
    <name>A0A183HJ53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7517</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007902">
        <property type="protein sequence ID" value="VDO51344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ53"/>
    <dbReference type="STRING" id="387005.A0A183HJ53"/>
    <dbReference type="WBParaSite" id="OFLC_0000751401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000751401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000751401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000751401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23711" checksum="1709F91D637FC9DA" modified="2016-09-07" version="1">MKPDYGMECVNPDDIACICYTAGTTGLPKGAMLSHGGLTWNAEALIDMWKFSQKDVLLHMLPFDHIHGMFISLNCSLFTKSSIIFRPKFDVNDALNWLPRCTVMMGVPTYYSRLLQKNSFDKSLAKNIRLFISGSAPLSTALWEDFNLRTGHEILERYGMTEGFIPSFTSSYIISLIPLFLSPPWVQFMPKCFAYLAEMTEIILVIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKF4</accession>
    <name>A0A183HKF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7966</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008677">
        <property type="protein sequence ID" value="VDO53405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKF4"/>
    <dbReference type="WBParaSite" id="OFLC_0000796501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000796501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000796501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000796501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12345" checksum="48927570F31A5604" modified="2016-09-07" version="1">MSTLMDLKIRIVSLVGSEKNGCTSSDLCRMYKDLYGTTLRPEDHGFMDVQSLLISPIMQGEGGIICENGRYFASADKNTRKLLDIVRNTKSRNSKLSRKFHAGVPAKFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKJ4</accession>
    <name>A0A183HKJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008736">
        <property type="protein sequence ID" value="VDO53598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKJ4"/>
    <dbReference type="STRING" id="387005.A0A183HKJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000800501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000800501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000800501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000800501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8660" checksum="CFB316CFBE37A529" modified="2016-09-07" version="1">MLKDDGGAEVTAAGRVMVAVARVLALSVHHSGLKPTFSLIGNRPRIRPHARSRLSNLSIISLTSRLDLPPCRKCSLFILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLH8</accession>
    <name>A0A183HLH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8338</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009327">
        <property type="protein sequence ID" value="VDO55145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLH8"/>
    <dbReference type="STRING" id="387005.A0A183HLH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000833901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000833901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000833901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000833901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12805" checksum="5B22E971985F6AF2" modified="2016-09-07" version="1">FSRFLNLLKFTIQIFKYATSSTTINLLTYTLPLIFDSRKCSFFRHPRYRSLWSNDEAISCWQFIKTIIGYNNCEAIIFVFLGLSTVSKKHNWDSVFIVTTLIACLKMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMZ5</accession>
    <name>A0A183HMZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8854</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010361">
        <property type="protein sequence ID" value="VDO57749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMZ5"/>
    <dbReference type="STRING" id="387005.A0A183HMZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000885601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000885601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000885601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000885601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9746" checksum="4018FCA51E9EBA89" modified="2016-09-07" version="1">MIIQTGTKLIVLLTDIHDQEGNRLVKHFWPESTANSRSYSESNVKVNYVKSGVVSFIFNFQFSNSCHSWAEKMIHLKFKNKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN36</accession>
    <name>A0A183HN36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8899</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010443">
        <property type="protein sequence ID" value="VDO57920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN36"/>
    <dbReference type="STRING" id="387005.A0A183HN36"/>
    <dbReference type="WBParaSite" id="OFLC_0000889701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000889701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000889701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000889701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9771" checksum="CE353E857684272B" modified="2016-09-07" version="1">MFAEQPRTTSPDDFFGVISKFLTALSECHQQIWEERENLERIKKQTMARSILSRKCKTFSQDVGKKKKNLIELYNLVCRFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNH1</accession>
    <name>A0A183HNH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9033</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010697">
        <property type="protein sequence ID" value="VDO58441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNH1"/>
    <dbReference type="STRING" id="387005.A0A183HNH1"/>
    <dbReference type="WBParaSite" id="OFLC_0000903201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000903201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000903201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO58441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000903201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15147" checksum="2FB0647FCF3E97D2" modified="2016-09-07" version="1">MLDVSVRVQSIRHFSVSQMALLIENAHLLLAGSAQHRSNMCEVLLAAAWICGEYCEHLCNVQGVLEAMLKAKISVMPGHILSVYMQNIAKLYAVLLTRAEEENDWDGIDSLDNLLLSKLPEFVLADHLEAQERVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP21</accession>
    <name>A0A183HP21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9231</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011111">
        <property type="protein sequence ID" value="VDO59279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP21"/>
    <dbReference type="STRING" id="387005.A0A183HP21"/>
    <dbReference type="WBParaSite" id="OFLC_0000923201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000923201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000923201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000923201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19742" checksum="5019C647C3D062AC" modified="2016-09-07" version="1">TGEVQHINYLAEHIGNLYITGECSDITLKVEGRLIPSHKIILAARSQYFRALFYNGMRETRDSEVELVDTSLNGFKMLMKYIYTGKLSLSSMKEELVLEVLGLAHKYGFTDLEISISEYMKAMLNVRNVCTIYSAAHLYSLRSLCDVCLNFADKHAPEVISTQVRTTGFKTAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPG1</accession>
    <name>A0A183HPG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9369</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011416">
        <property type="protein sequence ID" value="VDO60104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPG1"/>
    <dbReference type="STRING" id="387005.A0A183HPG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000937201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000937201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000937201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000937201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18449" checksum="456258D1D8EAD72B" modified="2016-09-07" version="1">MQICTISDQAGYRSYKQNESQEGLGTENLIRKEATPRNRGYRNPLYTTTTSTVKIRETFDRTIDDGNVYDKAGTGTDRGTGAGAEASTRLEINVQNDGRKQLNTTGIRRNGYQVTEPTSLPRTVSTTHSGQPSPGNYSTRETFEERCEENYVEEKKSVPEAKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPP2</accession>
    <name>A0A183HPP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9451</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011590">
        <property type="protein sequence ID" value="VDO60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPP2"/>
    <dbReference type="STRING" id="387005.A0A183HPP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000945301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000945301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000945301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000945301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11100" checksum="A1BB83BD48201ECD" modified="2016-09-07" version="1">MIVCKYSLFIATYASGVLKNLQFDKPLMYRGELDTEIESVINSGEEWMHDGLEPELFAEMYHSSGMEQLDHTQPWQHPPSYQTNNRSPLWFDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPY6</accession>
    <name>A0A183HPY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9548</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011822">
        <property type="protein sequence ID" value="VDO61368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPY6"/>
    <dbReference type="STRING" id="387005.A0A183HPY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000954701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000954701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000954701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000954701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="6403" checksum="3EB76121EBABA59D" modified="2016-09-07" version="1">MTKEISREQKWLRMISRWNDGKDISEKLKKRLWKGVPEKFRSLVSFDNFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ65</accession>
    <name>A0A183HQ65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012020">
        <property type="protein sequence ID" value="VDO62005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ65"/>
    <dbReference type="WBParaSite" id="OFLC_0000962601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000962601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000962601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF30">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000962601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12106" checksum="8A7B01EE40EF0354" modified="2016-09-07" version="1">MFEPIEALKGCPQNTTTIVLSHNPASTKEIAFNDAHLRVDLILSGHTHAGQFYTVAPIVYWMLPYYYGLYQVSPETQLFVTAGTLYQGAPMKMVWMSEIWIIELHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ74</accession>
    <name>A0A183HQ74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9634</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012029">
        <property type="protein sequence ID" value="VDO62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ74"/>
    <dbReference type="WBParaSite" id="OFLC_0000963501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000963501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000963501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000963501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6213" checksum="487D39D31E407B2F" modified="2016-09-07" version="1">MMIILDGNHSIEVAQRGDSVNGVTVMNEPEQQRSDDATIIGMQAKTGLLLEYYFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQW1</accession>
    <name>A0A183HQW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012581">
        <property type="protein sequence ID" value="VDO64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQW1"/>
    <dbReference type="STRING" id="387005.A0A183HQW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000987201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000987201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000987201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000987201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8486" checksum="F3522253F2683976" modified="2016-09-07" version="1">MKHEIVGNGYTSAHFDYTSYPATMHCYGSRGGYYGCSINPVSSSSSLYNFEVHHWGYSSGVERSLSMGEGWGSIPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRY8</accession>
    <name>A0A183HRY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013458">
        <property type="protein sequence ID" value="VDO67060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRY8"/>
    <dbReference type="STRING" id="387005.A0A183HRY8"/>
    <dbReference type="WBParaSite" id="OFLC_0001024901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001024901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001024901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001024901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12275" checksum="A72A0ED95BF536E6" modified="2016-09-07" version="1">MSMLHSSKQDVILIEKNERVAGNGRTTGGDFSSHNWPDDLIDIVNEPMGQTLDRMKKYSNSLSQVDRGTNCPRLSELLIKLRKNLEGRRLNSKFVLFSLKFKKEGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS04</accession>
    <name>A0A183HS04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SynN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10265</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013498">
        <property type="protein sequence ID" value="VDO67149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS04"/>
    <dbReference type="STRING" id="387005.A0A183HS04"/>
    <dbReference type="WBParaSite" id="OFLC_0001026501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001026501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001026501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF113">
        <property type="entry name" value="SYNTAXIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntaxin N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001026501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16788" checksum="D9074CFC94FB1201" modified="2016-09-07" version="1">MAGIKHRSGLLRKHLLLMKEDAKETEAEKIGGISKRIKQYHIEALSKKLSDLLEIFNAAQLDYRAQVSKRIKRQLDIAGEHVTEEEVNSMIDSKSSEIFNRHVRSSELKSAFDDASLRHNEILNLEASIKELNDLYNDMTFLIHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSB6</accession>
    <name>A0A183HSB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10378</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013770">
        <property type="protein sequence ID" value="VDO68019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSB6"/>
    <dbReference type="STRING" id="387005.A0A183HSB6"/>
    <dbReference type="WBParaSite" id="OFLC_0001037701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001037701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001037701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO68019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001037701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10486" checksum="DE8F87535A9B32E3" modified="2016-09-07" version="1">MYHNNSLQSFSQSRTRSGASFHNSSAFMSSVIEKLHLVKPIIVSPSASGSYSVPYVIENRSTIGGFVPVAACCVRNHKWRNFMVCFTKFKFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSF3</accession>
    <name>A0A183HSF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10415</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013850">
        <property type="protein sequence ID" value="VDO68274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSF3"/>
    <dbReference type="STRING" id="387005.A0A183HSF3"/>
    <dbReference type="WBParaSite" id="OFLC_0001041401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001041401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001041401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF16">
        <property type="entry name" value="CAVP-TARGET PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="70"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO68274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001041401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18132" checksum="A3C559ED31DA0573" modified="2016-09-07" version="1">MKDGVKLEQDNRIITEYREDGTVVLKIKNAKKEDSGEYRCDAVNKHGTAWTAGPIRIVTESELPKEGEAPDFTEPIKPVTVFVGETAILEGKVTGKPEPEIKWFKDENMLKENSNIKMEKLPDGTQRFIVKRAVVEDAGEYRCIASNKYGDVWSDVTLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSL9</accession>
    <name>A0A183HSL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cwf21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10479</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013999">
        <property type="protein sequence ID" value="VDO68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSL9"/>
    <dbReference type="STRING" id="387005.A0A183HSL9"/>
    <dbReference type="WBParaSite" id="OFLC_0001048001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001048001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001048001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21370">
        <property type="entry name" value="cwf21_SR140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047488">
        <property type="entry name" value="SR140_cwf21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWF21" evidence="2">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001048001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13316" checksum="F2A8B30465191679" modified="2016-09-07" version="1">MGKTDQEDDIDGAPIDDDKNGSEDGECPDEDDDDKTNLQQSLSSSTARLDEERRKILREIEVKVVKYQDELESQRCEDIPVQVEKYRASLLKQMEEKLDALNEQKDKKRKKGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUB3</accession>
    <name>A0A183HUB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein slx9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11077</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015527">
        <property type="protein sequence ID" value="VDO73604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUB3"/>
    <dbReference type="STRING" id="387005.A0A183HUB3"/>
    <dbReference type="WBParaSite" id="OFLC_0001107501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001107501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001107501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001107501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10420" checksum="6E21385507FFE3F4" modified="2016-09-07" version="1">MLEAVAEKTRKFHEHRVKQRKKQLEKKDKQRRNQSLRKIKPQASSTAANEESKFSKLSDTPIAKRTRSALHSVPVAKRLCDKKTVHRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUB9</accession>
    <name>A0A183HUB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015544">
        <property type="protein sequence ID" value="VDO73669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUB9"/>
    <dbReference type="WBParaSite" id="OFLC_0001108101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001108101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001108101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001108101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4903" checksum="935E6D04CAD1F8A4" modified="2016-09-07" version="1">MNNMLLLVKYTRTDPDENDSDAEDMVTEIKNIHEMQRNFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUD9</accession>
    <name>A0A183HUD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11101</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015590">
        <property type="protein sequence ID" value="VDO73832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUD9"/>
    <dbReference type="STRING" id="387005.A0A183HUD9"/>
    <dbReference type="WBParaSite" id="OFLC_0001110101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001110101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001110101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="MBT" evidence="2">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO73832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001110101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18862" checksum="71FB9017584B65FC" modified="2016-09-07" version="1">FLGYCAEKTETRALVPPEAIHKRQSNWQQYILSQIHAYKTIAINWPEIQIRKLSFCKFEEGDHLELLDSTVSSRIRPARVEKVIGTRIWVRVNQMFLNQSDIDDSDIQIDGGVWMDQDSPLIFPVGWALKVGYNLVANDKYIMHAEEVSIALKSVYFSVEIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVE2</accession>
    <name>A0A183HVE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11450</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016536">
        <property type="protein sequence ID" value="VDO76544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVE2"/>
    <dbReference type="STRING" id="387005.A0A183HVE2"/>
    <dbReference type="WBParaSite" id="OFLC_0001145401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001145401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001145401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001145401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21152" checksum="A3DBD1B06C937DAE" modified="2016-09-07" version="1">IVLNFISEKKKKKKREIHFRIVGERVTHRDRLSQQHRPARPQSWASTISTDSIRSSDTTTDSSVMDGNGNNPNGTCCSSPSSGSPTFVPVMSDEDPDNNVSKTTNDPLQTRSHSCPEVKKQSILNFILSLTINSLGGLSPLSSSSISTTVPSSGILNTIIPSSILAKSLITTTTTTTTTPLNTIVESSSSTELFATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVF8</accession>
    <name>A0A183HVF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016586">
        <property type="protein sequence ID" value="VDO76725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVF8"/>
    <dbReference type="STRING" id="387005.A0A183HVF8"/>
    <dbReference type="WBParaSite" id="OFLC_0001147001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001147001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001147001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001147001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19024" checksum="41CF5E94829A8B5A" modified="2016-09-07" version="1">QEKEEIISNESNLTIRSQFKGKVFKLPENCGRPQSSEGRTFPLKIRSDDMNYDSSDYNEPQSEKDFHHDSPDSSLKLISSMKHSSPIDQAPAVIRTATKIVRKTPSMQKILVPNMGITNTGNLSSEIAKPIKPVSSNGTMSKNGMSWRRRQANEDLEVEDEVSLTFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW45</accession>
    <name>A0A183HW45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol transfer protein beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017251">
        <property type="protein sequence ID" value="VDO78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW45"/>
    <dbReference type="STRING" id="387005.A0A183HW45"/>
    <dbReference type="WBParaSite" id="OFLC_0001170701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001170701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001170701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001170701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10579" checksum="F2CB1BC713C7A302" modified="2016-09-07" version="1">MTVEEYQVGQLWSVAEASKAETGGGEGVEVLKNEPFRNYPLLDGRYSCGQYTHKIYHLQTKVPTIVRTCAPKGSLAIHEEAWNAYPYCKTVLTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW81</accession>
    <name>A0A183HW81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Photosystem II reaction center protein PsbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11743</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017386">
        <property type="protein sequence ID" value="VDO78849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW81"/>
    <dbReference type="STRING" id="387005.A0A183HW81"/>
    <dbReference type="WBParaSite" id="OFLC_0001174301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001174301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001174301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001174301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7577" checksum="A3408A27112BE66D" modified="2016-09-07" version="1">MKVRGNILWEFGFYPTWLAPNVLTLTGFMFVTFAFFVVSYYDYYVGVNSKILAENSGKAFFNVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWW8</accession>
    <name>A0A183HWW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11983</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017990">
        <property type="protein sequence ID" value="VDO80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWW8"/>
    <dbReference type="STRING" id="387005.A0A183HWW8"/>
    <dbReference type="WBParaSite" id="OFLC_0001198001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001198001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001198001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001198001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6701" checksum="5EC053717FAEA133" modified="2016-09-07" version="1">NIGRDPSRSKRAIQRAVEKRFAAPFNVICSKGDFTYVTHAAEYCEVSSRGTVCYAFRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX93</accession>
    <name>A0A183HX93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018351">
        <property type="protein sequence ID" value="VDO81951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX93"/>
    <dbReference type="STRING" id="387005.A0A183HX93"/>
    <dbReference type="WBParaSite" id="OFLC_0001210501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001210501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001210501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001210501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8868" checksum="29D906CE0E848A52" modified="2016-09-07" version="1">MPEKLLTTTGCPEKTTAPDTVEVDPGEPDNKPQEATSKTPVVVPTTVPNLAPFLLRPPHTMTQLLYEQQKVIFAQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP3</accession>
    <name>A0A183HXP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018785">
        <property type="protein sequence ID" value="VDO83217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP3"/>
    <dbReference type="WBParaSite" id="OFLC_0001225601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001225601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001225601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001225601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3910" checksum="2ADB5C92B99D616B" modified="2016-09-07" version="1">MIVMNATDSLWLNGWIRDGERFIHVLITCCACNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXX0</accession>
    <name>A0A183HXX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019028">
        <property type="protein sequence ID" value="VDO83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXX0"/>
    <dbReference type="STRING" id="387005.A0A183HXX0"/>
    <dbReference type="WBParaSite" id="OFLC_0001233301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001233301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001233301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001233301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12164" checksum="BD7F990DA2485316" modified="2016-09-07" version="1">MNGTFYLITEVCVPLKIYIMENKLTEKQKDFVVSWGLFQLMSCLKFLHQEAELSHENIRNSVYVTESGDWKLSGFEKSTNFSNPRVDLNSFALLIWEIFNGFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY47</accession>
    <name>A0A183HY47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12409</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039837">
        <property type="protein sequence ID" value="VDP11255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY47"/>
    <dbReference type="STRING" id="387005.A0A183HY47"/>
    <dbReference type="WBParaSite" id="OFLC_0001241001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001241001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001241001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000226">
        <property type="entry name" value="Vesicular GLUtamate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF206">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001241001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="63122" checksum="3F2FBEC61F1E6881" modified="2016-09-07" version="1">SKCQGSYFNIYVFSQDVFFLKKKRWQTAVLANVGFIIAFGIRCNFGAAKGRMISNFTDPFGNNHTQQFYWSPTELGFMESAFFYGYAITQIPGGMLAAKFAPNLLFGFSILIAAVLNLFLALALKAHPYTDFIVIAIQVCQGLSLGVSYPAMHGVWRHWAPPMERSKLATTTFTGGYLGVMIGLPVSAYLVSYIDWCAPFYFFGVAGIVWFLIWFAVSAPTPEKSKSISDDEKRFIIEQVGQVTSSPATLTTIPWKEILLSLPVWAIVISNFCRSWTFFLLLGNQLTYMKDVLHLEIQSVIHFSFCHWTFIHWSLSNRLMKDLISRESQSTTTRGGLISSLPHGLMSIVVLASGQIADYLRSTGKMSTQTVRKLFNTLGFGGEALFLCCLSFISEPTAAVTTLIFAAGCSGFGIAGFNVNHFDIAPRYAPILMGFSNGISALAGASSFILEHLIAAQGNEKGWRISFLIAAAIDLTAMFTFLIFAKGELQQWAKEKEPQQSMGDIVRRLSYIVRRMSSRRQPESKVKHKRLCEENEAKCDWSTRTTVEKDIQRIKEVKFRNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYC4</accession>
    <name>A0A183HYC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12486</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039853">
        <property type="protein sequence ID" value="VDP11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYC4"/>
    <dbReference type="STRING" id="387005.A0A183HYC4"/>
    <dbReference type="WBParaSite" id="OFLC_0001248701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001248701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001248701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="207"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001248701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42894" checksum="5F0265A582DC8CBF" modified="2016-09-07" version="1">MIDFSFIVYKLFQYSDLQQIYFAVETGVDVAVEFWVQAITSINEITNDFEMEIYINEMWLDPALNFEHLTPCKDNLSLNHQVLDRLWTPNSCFINMIKLTLISCNLLQRVRVKGPCIMDLSNFPMDVQTCHLIYESFNYNNQEVRMRWNTINPNPVYVVSQIMLPDFILINISSGLRIEKYPAGMWDELHVNFTFERRCIWYFMQAYVPTYLTIFISWVSFSLGPRAIPARTMLGVNALLAMIFQFGNIMRNLPRVSYIKAIDVWMLVSMTFIFSSLIELAIVGSKVKNLESGQRPRKLHCKNIEGVESSPKGLYEFEKRFMLPVEGFELKWCRSRWKSASWTPDRIDRLSSIIFPAFFACFNVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYL5</accession>
    <name>A0A183HYL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039872">
        <property type="protein sequence ID" value="VDP11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYL5"/>
    <dbReference type="STRING" id="387005.A0A183HYL5"/>
    <dbReference type="WBParaSite" id="OFLC_0001257801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001257801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001257801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001257801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20068" checksum="7878130F46131751" modified="2016-09-07" version="1">MINRGVLNIYRPNKNPDKNLYGDNLDKFSGAESGVARNFKPGEFEKKEEYIFSIGQLLQSAKELRKRLKKKATDEGPLASKKLLDKSKVSLNKDGRPYSSSDEKKCQIMNPVHENKMCGSKRIVGTDSDSLLFGNSNYKTSWFSYEKRPAGRRISFKTVSLTSDIYNDISGDKHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYV6</accession>
    <name>A0A183HYV6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12668</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01039898">
        <property type="protein sequence ID" value="VDP11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYV6"/>
    <dbReference type="STRING" id="387005.A0A183HYV6"/>
    <dbReference type="WBParaSite" id="OFLC_0001266901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001266901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001266901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="8">
        <location>
            <begin position="65"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001266901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27054" checksum="94135C05947D3388" modified="2016-09-07" version="1">MILKDNAPEVVDQCDSAPSSSSEGEEEVLNFTADSSDRVYWPPRESTTFVAPWCRRRYALSLRGLHEELLDLYAWLKPSPLEKALRLRVFERVRGVLQRIWPAAKIDVFGSLYTNLFLPTSDIDVVVESDSVSEEPPLWKTAIALKESGITESINVLDKAFVPIVKMVDKDTKIYLDISFNTIQGVRSAKFIEDMKIRYPVLEPLVLVLKQFLMQRQLNQVQFFMPNDLTSNLSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0F1</accession>
    <name>A0A183I0F1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein alpha-12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13213</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040091">
        <property type="protein sequence ID" value="VDP13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0F1"/>
    <dbReference type="STRING" id="387005.A0A183I0F1"/>
    <dbReference type="WBParaSite" id="OFLC_0001321401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001321401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001321401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000018">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-12 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001321401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="42745" checksum="8253620FF88CF90E" modified="2016-09-07" version="1">MLREAFTLCCGKSKDEQTRVIEKQLQKEKKQLRRQVKILLLGSGESGKSTFIKQMVIINGRGEFTADEVRAYRQQIYQNVIAAMRVLLDARQKLGYAWKNPERQKNVDAVMRFTASDMMRGIDHSTFAEIAPLIRDFWEDPSLKQTYEQRNLFQISDSCIYFFDHINRVAMPDYYPTNRDILFCRKATRGITEHVFEIQRVSFRFIDVGGQRSQRQKWFQCFEGITSILFMVASCEYDQVILEDRRTNRVVESRSVFETIANNKSFANVSIILFMNKSDLLEEKVPKSDIRQYFADFTGDHNSLRDVQFFLLDKFENCRRDKRRPFFYHFTTAVDTENIRRVFKDCRETILEQNLKALMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0J3</accession>
    <name>A0A183I0J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13255</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040112">
        <property type="protein sequence ID" value="VDP13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0J3"/>
    <dbReference type="STRING" id="387005.A0A183I0J3"/>
    <dbReference type="WBParaSite" id="OFLC_0001325601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001325601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001325601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001325601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10326" checksum="0188E32F3538FA2D" modified="2016-09-07" version="1">MKIVKVLAMDPDLINASSLNSDSDSVRYGIDETIYRYGDRVRQANGFINMDEKSGIVRLAQPPYDSAGGVFESRITSTDLSDIASHVATTKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0R3</accession>
    <name>A0A183I0R3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13325</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040144">
        <property type="protein sequence ID" value="VDP13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0R3"/>
    <dbReference type="STRING" id="387005.A0A183I0R3"/>
    <dbReference type="WBParaSite" id="OFLC_0001332601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001332601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001332601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001332601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="52897" checksum="B0FBBDADB9B77C18" modified="2016-09-07" version="1">MFAFRSRIGYQSIDDESISSQAYLTNNEQTLLIPERRVPEDDGPSDVYGGPPLEHGIVTSEEDRTAACYAATSSGVLWDGVENLDQFFTRVYEYHQNGGYLCIVIKHILTLLQFIFVVWFVTFLQARVDYDVLFKNKNITAGGKPTSGKIRLEDVIYPDWSHIEVFTLCLLIFAILFWIFRAARVFYQIYQFGEIRTFYHSALVSLDEKIFMNTFEGIEDALLSDLKWQEVVQLICEKQPSIHLILNKDGITALDLYQRILRHKNYFVALVNKEILPPIINVPFIGSMPYLPNGLKMNLEWLLFYGVWSPWKGPYELKEEYKHAQNIFRLADELDSAILKMAIGNFIFFPLVFIYQVLYFFFTYGELLKRDPGSFAMRRYSNFGRNKLRHFNELDHELRIRLSKSHRAATQYMEQFLSPLWQVVARKVQFVAGAICIVFLLLGLWDEDVLSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Y6</accession>
    <name>A0A183I0Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-processing factor 40 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13398</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040180">
        <property type="protein sequence ID" value="VDP13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Y6"/>
    <dbReference type="STRING" id="387005.A0A183I0Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0001339901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001339901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001339901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000003">
        <property type="entry name" value="Pre-mRNA processing factor 40 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000002">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="239"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="456"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="593"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001339901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="731" mass="85006" checksum="DFEC2D3AC3CDEC8E" modified="2016-09-07" version="1">MLPFGGPPFSSLMNIPPAAAAASQATYLQQQVIMPPLQRIPMMTVSSTPAPLQLPQVSVASPATTPRPMLVPPQMQMEIAAAAQSPRTSSIGTTLVSSDIWSEHTASDGRVYYYNKVTKQSSWQKPDELKTPEEKKLAAAKLWREYKTPEGRPYYYNIETKETTWICPKDFDPAVVTKVKNGVESKGSDTSKTEPQSGGESELEKAMLATLKSLEQPNEQIGNTKEADAEDVEEEKDLKQKQSDKFRDLLRDKYNEGKISSTSSWEQAMRYIQHDPRFRILNKVSEKKQLFNAWKVQRQKEERDEKRLAIKKAKEDLEEWLQNNPKVRPTMRYSKAEILFADEPIWKAVHEGERKEIFADALEFIDKREKENAKAIRRRNVQALADILEGMEEITYRTTWAQAQRLLIENPSFANDSTLQNMDKEDALIVFEEHIRTAEKHYLKEKDMEERRRRRQERKIREAFQAYLVELHKRGELTSISLWSELYPVISADSRFDNMLKQSGSTPLDLFKFYVEDLKSQFGQDRRVIKEILKDLSVTIEVGTTFDQLCKWVLSDERGKTVDPGNMKLCYNSLVEKAEAKEKEQEREEARKRRRHETAFRNILRTLVPPVEPNSQWEVIRPKIENEEAFITVETEQLREKFFNDYLQNLAEACGHHHGSSKKKKKDKKKRRKEEKESETEGESRSKKKKKHHKSDISDEEKVLRYFTEILLNEPVEKQSKEDSPLQQVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1E9</accession>
    <name>A0A183I1E9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13561</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040267">
        <property type="protein sequence ID" value="VDP14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1E9"/>
    <dbReference type="STRING" id="387005.A0A183I1E9"/>
    <dbReference type="WBParaSite" id="OFLC_0001356201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001356201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001356201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001356201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13185" checksum="5884C5B57AF00970" modified="2016-09-07" version="1">MELDDSTKKALKAIPLMKTKAGPRDGDSWVQRLKEEYEALIAFINSNKAADSDWFRLESNSDGTKWFGKCWHYHNMLRYEFDVEFDIPITYPITAPEIALPELDGKTAKMYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1K1</accession>
    <name>A0A183I1K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040294">
        <property type="protein sequence ID" value="VDP14207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1K1"/>
    <dbReference type="WBParaSite" id="OFLC_0001361401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001361401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001361401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001361401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8261" checksum="D58E28B351C82FA0" modified="2016-09-07" version="1">MIEVRTATEENCSVNGKRRNKRYCPSCKEALVISEKIASPLRIGGLLNSVQSNFNSFAARAIKLHFARVQRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1L4</accession>
    <name>A0A183I1L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13626</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040302">
        <property type="protein sequence ID" value="VDP14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1L4"/>
    <dbReference type="STRING" id="387005.A0A183I1L4"/>
    <dbReference type="WBParaSite" id="OFLC_0001362701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001362701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001362701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="268"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001362701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="695" mass="78899" checksum="01C1501069FCBA33" modified="2016-09-07" version="1">MFRHTAFRLETCLFSGCMQNLGNLIRNGKLVHCSSYCQNFIRKKHTGYYLLPVRKNYLLALTFENSCRPFFRNSGYSRKSQKHSRNVALHSDFHEKVNRWKELLKNEVASSVKEIRDLLMNPSIDELEKLGQISGTLRFQTQYLHALHGRVIVLRQVKRVEQKITKKTFRSGTPVLLCRIPELTSVSDCIVISCSENQISLKAKAKKEVDIGSSDEFVLIPSVGLGYLIALDEFLELKWRDFPGEKLIHYVHCSVPLPTSRPDEVSEKAIKLNEDQRHAVAAALNKSRPIVTIHGPPGTGKTAVIAQIVMEAVSRKQKVLICAPSNVAVNNIVDRLKDLSSICALGFNSELSLATELEQHEKFIDIQSAFKKLDSGEDNEISGNNFDENKKAWLDANKMLWQLKESILSCKQVIVCTLTNSSLRFLREQGFQPNLTIIDEAAQALECVAWYSLLLSPRAVIVGDPWQLPPKIYSFRWPSSFFYKSQLRPNEHIANQVLSDISEVPKGSLFDEPMIFIDTSHDKSAENKEELYRYSFANKLEAKLIIKYVNALSVFGVREEDIGIIAPYVAQVDLLKKSLKTSRVNSVDAFQGQECEVVVMSLVRNNSDGRIGFLKDERRFNVAVTRARRQFVLVGNAAMMKHAKHLQSLIEYMQSHGRIVEQQELTECLDISKNSKKIQKLLLRKSKPLAVQDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2I1</accession>
    <name>A0A183I2I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIMELESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13943</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040488">
        <property type="protein sequence ID" value="VDP15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2I1"/>
    <dbReference type="STRING" id="387005.A0A183I2I1"/>
    <dbReference type="WBParaSite" id="OFLC_0001394401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001394401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001394401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26019">
        <property type="entry name" value="HTH_TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001394401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="957" mass="112460" checksum="38B924DADF06075B" modified="2016-09-07" version="1">MERIIQSTINALGFLENGVYYPEPDCFESIRDLIRFLRNDTAMAIARRVCGERNIIRYDLIPIMKSPNTSDKLFDIALRLTINLCQPVALMFGERRTEDKKTWLVYQEIEKNLRNSKEAFGDVQLFKIFERKAATYFAQDWLERDEETKLLIERIFALSRYVLTVGDTDLDMERLPQDMNSHDQLVLAFLESGFGKLLVGISENSTEHDFHLYILEIFAMLLKQYEARDVVEAGSINTSEERKRQETEMQKIVVQEMEKQLNKRRHMSSRHTAFAGSYILKGLKAINKENDMIVNKVIKNCNEIDHLNKRKIQQRIPKNRRPFDIETSKHISVLNVRMVLRSFCVEMLQKSYCRLMCGCKDSAFSGKRTLGQAKTDIHYFVLMQFSLEFCRLAGLSPEYIRTSLSIEVFHHVQTQLDNYLERARIERKEGHIHGLRAQYAIAAYKELLLTLVSILKSGSEEWKRQIESTCSHILRVEEYRDLSSCIIRRFMPGVFSKTFLRNIVLANHSYISLIEKFSKKGMLSTVVKRQKIRRRKSKREEKLENIVQESIRPDWILWDDICEELSDVIFGYVEPTVDISAIDVLLNVEDRLHQQFAMLMVQHALWQRRIADAVGIFRSARDLWPADGVFGVNDITPEDEFLELRAIYFVDLREVEANWEKCRLETYGPEPNYNTTNNDLFSVELDGFNEEHEEENDESDDETSVVEKEIDFHFNDYIAKFARTDVLKWYIFLLADFESNAVEVNKAILKLLHRVAFDLKMAPRLYQLSLFVIFNGLAQRFKDQSISEIKKSQYFEIYQFGYHVLRRFYVDYHKIGSKLIPELLFWKGPKECYEIANGYGTFEIKQDGSKGKEILWPEELDNELRILYDEYLLFEEKPEGVDIVEYIEQGLSRPRRRRQIIRQMKMLGLDTFSARSTRRNMERGIKSSIFMPEIVNEMRNLIKEFNSKSPSCRPGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2N5</accession>
    <name>A0A183I2N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CEBP_ZZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13997</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040523">
        <property type="protein sequence ID" value="VDP15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2N5"/>
    <dbReference type="STRING" id="387005.A0A183I2N5"/>
    <dbReference type="WBParaSite" id="OFLC_0001399801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001399801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001399801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cytoplasmic polyadenylation element-binding protein ZZ" evidence="2">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001399801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21176" checksum="2AF63B100C90A771" modified="2016-09-07" version="1">MLLQQTIGDVVYVSLEVDADTKYPKGAAQVIFDSRESYLTAIAMRLITLTTTDQVKEIEIKPYLMDSVQCEMCNLVNARHLCPELCCLMYLCELCWNEVHKRRGLLHHRPMTKAKPGTPLRNISNCVTGFPFSNLPLDHLNNHNGLRSNNHQPQCHCRAREALPLQNLLQQCILQANLMSSRSPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I328</accession>
    <name>A0A183I328_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS14140</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01040619">
        <property type="protein sequence ID" value="VDP15633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I328"/>
    <dbReference type="STRING" id="387005.A0A183I328"/>
    <dbReference type="WBParaSite" id="OFLC_0001414801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001414801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001414801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="106"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDP15633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001414801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="50018" checksum="5B4D9FE6F5E64E2B" modified="2016-09-07" version="1">MRKFWLPLRRLLKRSGTVILRYGRPVLRSEVLGRGLTEKHWSIYKCSYQKNWRSNNLLGISRQHTSLLKIYSNREVSERIKKLFLTNTRYNIGLRSTEVPNRLEDYEIGSNIACGCSAAVYEARIRTTEKVENYPSSICTNSSSTSSVLQREQSDAEDPVVAYPYALKIMYNYEFNASERYLWMDMGTELVPLIEKPPELIGYMANMSFLPHAHPNIVQMYKAFTDCMPILEDARRLYPEALPTADFHELIVDEPKTLFIVMRRQITCGTSIPNDFTRIHDVPHLVLSDFGCALAVGTWKVKYDTDTVYLGGNLALRAPEATSNYWVDFRMADLWAAATVGYEIFTRTNPFYSRMRSDQYMECELPPLPKKMDYSIKTIIWNMLQIDPNKVIHILKYSLQDLPDWRNRFYTNETVELYSNLLTVIIVDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5A4</accession>
    <name>A0A183I5A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14914</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041351">
        <property type="protein sequence ID" value="VDP19559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5A4"/>
    <dbReference type="STRING" id="387005.A0A183I5A4"/>
    <dbReference type="WBParaSite" id="OFLC_0001492701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001492701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001492701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001492701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13241" checksum="283961E5E74E81BF" modified="2016-09-07" version="1">MSRIEEKLELCFKNGNYYEAHQIYRTLYNRMSNQGKWQELQNMLYSGVLRLLAEKEMASAIDLAELFVDTLEKSKTPVSSVVLDRFEKVGLHISFYYLFLMNANKKNLNLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I617</accession>
    <name>A0A183I617_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041723">
        <property type="protein sequence ID" value="VDP20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I617"/>
    <dbReference type="STRING" id="387005.A0A183I617"/>
    <dbReference type="WBParaSite" id="OFLC_0001519001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001519001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001519001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001519001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39043" checksum="052565CA38DE24E2" modified="2016-09-07" version="1">MGIKKTKKFSPAPTKRDSPSILTSSPGARMSPSLTKINAEQPGYGSELKIMIKLKQQAPTRPSIGPSQSSSGGVPSSMRLVGQPPSSSRSKEEKALLRQKQLKEKNRSASDERARKAGKRERKGEFNSSSKKLKLDRPLNEQKTTTTVSPKVEFPQALAFASLKNFKIPKVMENEKCESPTPTTTTTPAVATPSSSSAHLNVSQNSSSSTVQTVSSTSLSATITTTPSSSSSSGTSSIFPPKPKSILKSSVEPPPPPLFRGMGGMPPMLPGRRPLLPDPRNVMHHPPRPLVTIPRMIPSVLSGGNFMPPPSSSGRWMALAPQRQPSPRNSPSEQSASNSGLSETAAAMSKMQDSPTEALKIVADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I679</accession>
    <name>A0A183I679_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15241</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041818">
        <property type="protein sequence ID" value="VDP20974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I679"/>
    <dbReference type="STRING" id="387005.A0A183I679"/>
    <dbReference type="WBParaSite" id="OFLC_0001525201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001525201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001525201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001525201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11605" checksum="AC9436418FA48371" modified="2016-09-07" version="1">MYQEDRDSITNLSLSYDVEQFRKRMAPVLKKYPSYDTMFTLERWLRSYDNDIEEATKRMTRALQNLYALDAYRNYDSAESLNDFLHTINRAADYLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I784</accession>
    <name>A0A183I784_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smg4_UPF3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042429">
        <property type="protein sequence ID" value="VDP22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I784"/>
    <dbReference type="WBParaSite" id="OFLC_0001560901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001560901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001560901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001560901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16469" checksum="956E0027C511F1EB" modified="2016-09-07" version="1">LRTFEEKKKQHANDARNLFKVYEDEWKRIEHLTMSRRQQASNQSREGDQPRDDNKPRESDQPRDAKKLREIDQPRDDNKPRESDQPRGDKKPPEIDQPPDDNKPRETDQPLDVSSKRLDPSKASSSIPKISGKKKGSGSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8I9</accession>
    <name>A0A183I8I9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16051</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043789">
        <property type="protein sequence ID" value="VDP26524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8I9"/>
    <dbReference type="STRING" id="387005.A0A183I8I9"/>
    <dbReference type="WBParaSite" id="OFLC_0001606401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001606401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001606401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001606401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5435" checksum="A011DCEBF621E8FE" modified="2016-09-07" version="1">MIGDEVLLNCTITIGAETNGTNGEVEWWRDGQRIDFKNTKSLQIKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U6A4</accession>
    <name>A0A3P7U6A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000309">
        <property type="protein sequence ID" value="VDO27089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZY3"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052137">
        <property type="entry name" value="uS15_ribosomal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46685">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46685:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="356" mass="41827" checksum="B25C89D12356655C" modified="2026-01-28" version="1">MVVFCRNALLCTNACSRVIIDGYRSIYLTTINRQSSRPRFPFFNKHMKVTDPARQDPNHFEKLAHEVPLDEQYVDTLTLLWKEKIGSEREVTLKGDDRMIGREPKNWVPEIDENSPKANYAELDWEGIPESVKRIFSIKFGERRDYTDAWKKALIDKVRKHKLDINSLEVKIAWTTGVIRSWTLLVKEIDNKPKKPTYIVHPLHLMIAFRRKLLRQLREVDTAAFEKVLSELKIAYHVPKRPEEQIEKRRKAWVEALLKERIEKEKDIKMEELNKKYTAERIQYGPEIKKRLEELDVEEGMINARLEELASIQGEMPENLPKYQPKLIEELSEVAAHAILYHHPGGSQRNNKLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VTE9</accession>
    <name>A0A3P7VTE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001804">
        <property type="protein sequence ID" value="VDO34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VTE9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="120" mass="13257" checksum="1CFC611154E2C4C7" modified="2019-02-13" version="1">MFKELDNSQYNPEELICGGCSDVVGAQVCGRHGVDFLEFKCRFCCSVAVYFCFGTTHFCTACHDDFQRLMSLPTKLLPKCPAGPKAVQLDGNECPLKIKHPPTGEEFPLGCGICRNINTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XMJ0</accession>
    <name>A0A3P7XMJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000273">
        <property type="protein sequence ID" value="VDO26855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XMJ0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="47" mass="5114" checksum="6F2E2A72445CA992" modified="2019-02-13" version="1">MQIDLEAGAKLQKLSDFTTVFFGPHPLITDGTRSVKCVQVGDGNIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y823</accession>
    <name>A0A3P7Y823_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002474">
        <property type="protein sequence ID" value="VDO37132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y823"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039988">
        <property type="entry name" value="MTTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024:SF0">
        <property type="entry name" value="MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024">
        <property type="entry name" value="MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vitellogenin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="439" mass="50821" checksum="FEA4AA7E65C0694B" modified="2019-02-13" version="1">MQLKLVLQESNNEFPDKKADVLASLVNSILFATDQDLLDAVREFRNTPIMPVFVDAIGLAGTKKSYTVGKNAFTTEAPEFLERFLQALAQTTKIDTVIINDLKAWMKSINDEYYEKYIAFTAANLYRRYCESTRNRKYECENGKNEDVNEFMEYIITRCKDSNCQINAMQIFENLPLLRLLPYAGQFLCSTDNDTNLVQKEALRFLQLFDGKHFDWKTIIKLLRIFHNTCPLRQTVADQILAIEILLNILPNIELVGTYLLRQESEELFPTEQEKWAYFYSGIAQRRQTSPDFNLYWTKMRSFRVFQPNYAHRSLKTTSETAAINIAELSGNNNITVWVKTASDKGILLWNDFSILFTSKKQLSFPIMQIFVEMKGLKSYLLDSESYDNDEDMDSENPLAVAQIGFLNNRDVPMTIFDGYSELINVVWNADGQPMHLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y8L6</accession>
    <name>A0A3P7Y8L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019092">
        <property type="protein sequence ID" value="VDO84170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y8L6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="97" mass="11194" checksum="AD62D855F6A1CF52" modified="2019-02-13" version="1">MKALNKDCSVEVPEGILVDFGSNPTDENAQRVFDEAAVNDVTEMRDLVIGYRNQNMFLNQESLEDRERRIIRQNFDIEACYYQLKSRSGTRSNRGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YH09</accession>
    <name>A0A3P7YH09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003223">
        <property type="protein sequence ID" value="VDO39602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772927at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="210" mass="24069" checksum="54F26DE73966490C" modified="2026-01-28" version="1">MTNVFQSREVAVDNEKKPFVYDKDDEFYLAPAVCHLMHYRNAAVLGGILEIVLLILAVLAFLNLELENANIHTWLLVILIIFPIFATVTTLLMIYGIVTEKPKYIWPLMAFMHIEITILIIAAIASITSMSMGLQATHRLFGFYVSIQKLENHFGPIWPFNLAVMSFFGATIIIWSYIIIRGAYDYLLDKEYFTKKPNIEMVKTIVVNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YS36</accession>
    <name>A0A3P7YS36_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS4439</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003375">
        <property type="protein sequence ID" value="VDO40015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YS36"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF898">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO40015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="331" mass="38209" checksum="A98790AB58385721" modified="2019-02-13" version="1">MNLFQFRIIIARKERQTNNPHRRNKRKVITGGIYRWPKNSNIPYEFAASDTLHFWQRETCIRWQEDGPGFDRIVFFRGSGCYSNVGKTGGRQEISIGYGCENRGIVTHEIGHSLGFWHEQSRPDRDQYIKLQSKYIASGTEGNFVKRSYLEIENMGIPFDLGSVMHYGPNAFSVDSNHTTIETVDKRYSRTIGQRYGPSFIDVKQMNRLYCNQNCAASLLACQNGGYPDPNNCQYCKCPIGLGGRICTDVQPSICGAELFATNVWQQLAYKGSRKCYWRIRANNTRIRIEIESVNFRCDITCQAYVEIKHNSAFEQTGFRIWLLFFLQICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YSM1</accession>
    <name>A0A3P7YSM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017815">
        <property type="protein sequence ID" value="VDO80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YSM1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="174" mass="19811" checksum="533E90F051F01D74" modified="2019-02-13" version="1">MYFSALSVQSFGEDNASISETSQDYSVNNRYVGHSPRNTRGYDVLNNTIESANQNGESSLRLGVNRAVQEPGPIREDVEERQDNNGLQDRQSAAAVWTPPTFRTYRPPCNVDWLNPRVRDVLRKYKSSKINSREGAELITKITGSQVSTTTVRVKTRMLDELKRDCDFYLNKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YWA7</accession>
    <name>A0A3P7YWA7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003951">
        <property type="protein sequence ID" value="VDO41375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YWA7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ral GTPase-activating protein subunit alpha/beta N-terminal" evidence="2">
        <location>
            <begin position="191"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="396" mass="44804" checksum="85A6900589EB4977" modified="2019-02-13" version="1">MDKFLEYCTRETIRIEWNDENIRLECAKFILDRVIVLYIYEIFPDIETNGVDIYGGWEGSEGQIDIRDTADPVVIARYWLIRWMATVALTTNNDLATTGQLLYRKALFSSRKATNTLLTLLKEAVMLPLPCSNVIHKVFSLINTWLLQRNLPPFIEQEGIAVESLSLLLIHFLTSFFHSPYLLAAGERLSSAISLTQSLLQTTRDLSNPSTHLQNSLSTRVWCELIKSLADGVRTVTSRSDAYGRATSGALAQNLLGVIVFVRAISGIEIEERVWDDVLAVFQSGCWMQMIEQWSRVVDSVTRALILNLFKVDIAPTAQSTSHQIVKRVKSNETTSTQEDGNAEFSEETRSENDSTVGDENAQFTSVVQDDFFHVSLLLETNKETIFIEKTALFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZN56</accession>
    <name>A0A3P7ZN56_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007735">
        <property type="protein sequence ID" value="VDO50895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZN56"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="119" mass="13671" checksum="BCDB0D90E0427D84" modified="2019-02-13" version="1" fragment="single">MQYFYHEKQSTRQLCYPQAVHAKTGDILRLRDSVRVNSIDGEPNFACICRLFNDPKTGKKKFFSSTFGAPLASVLWYYTPMQVKADSSLVPPVFERELLASKHMDIIPLDTVDEIVWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BA77</accession>
    <name>A0A3P8BA77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040299">
        <property type="protein sequence ID" value="VDP14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1L0"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="181" mass="20812" checksum="FD3316169D42D9E6" modified="2026-01-28" version="1">MLIFKDAFTDDELASDSFPMKLVDGLIWEFKGRLVVRKEGEIVLAGANPSAEGEDGDEGSEECVERGIDFVLNHRLQEMNCYEDMATFKSYCKSFMKKVVELMQKNGKSETEINEFKRKIQAWVISLLTKDRFKQLQFFIGERMAEGQGEGQVAVVEYRDEEEGEVPYLMLVKEALIEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXT0</accession>
    <name>A0A183GXT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Titin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS40</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000009">
        <property type="protein sequence ID" value="VDO24306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXT0"/>
    <dbReference type="STRING" id="387005.A0A183GXT0"/>
    <dbReference type="WBParaSite" id="OFLC_0000003901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000003901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000003901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000003901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22448" checksum="E1E11223E7B4CAC8" modified="2016-09-07" version="1">MAENDEEEIELSDVEYEDEEEEMECELVSEPAKKLEPRSTPNTVPDNITAVPDVEHNIGSKQPEKQKTKRPVELEEPQKVSSPTNKKPKPEKGPTTSPISESNLKRPENNPKSAATKKPIIPEKPMTVKEPIKIKPTENDRESQADITLPLPKAKKPMTESKKPDAKPQKKPKESDEEEIEPELVSAPTPKKPNLKLKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY60</accession>
    <name>A0A183GY60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS170</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000043">
        <property type="protein sequence ID" value="VDO24818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY60"/>
    <dbReference type="STRING" id="387005.A0A183GY60"/>
    <dbReference type="WBParaSite" id="OFLC_0000016901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000016901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000016901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO24818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000016901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="503" mass="55597" checksum="D7B7B7ECC17E165B" modified="2016-09-07" version="1">MSEKKTAVGNSTSANDLHDVRNVAQSSKPAVLAKQNGIDEEEVERCSDKFKANNEEIKEAATVRIQQISDNNLHETVLMPPHHISLNVTVSTKSKVLVRSHAFSGDDDSGISARHTPTSRFPASRSTFSSASFDSGHGHDYTDSTGINLLSFITCTLHKNSKDRHMLLQLEQHMTKLIKDPTRNSQKFPAMSSYNRMLVHRVAAFFGLDHNVDQNGTAVVVNKTSHTRLQSDVYTDEPRRLLRRDAQSYEEVGQSLGAGMIFGRRARSFEVSDCLSSDPTTVAIGCALPVTASLHMHLLHQQGSTSSTDVSSTHLLESPGSCYSYGDMPVMGVYSASESSPSLSSATHMFPWSSSESYTSLSADYPSNLISPTVHNYPRPSMITREVNIDTSTPLYRTLNTRTSFSEQRTPISKPINADWHRREAVYSKEASIQENLLPENVHFADEYGVEIAVSQQQVHPLYAPPPVSADFISNQYINPVQEQTTYAVVPPYVRYAAPTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYE0</accession>
    <name>A0A183GYE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta_helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS250</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000071">
        <property type="protein sequence ID" value="VDO25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYE0"/>
    <dbReference type="STRING" id="387005.A0A183GYE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000024901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000024901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000024901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF4">
        <property type="entry name" value="PROTEIN CBG15747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552300" evidence="1">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="63"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="223"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000024901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35927" checksum="0E72EAA9A4CD0C82" modified="2016-09-07" version="1">MMYSIITYILPFMLVFTILSASAAVHQKDHTSFILVPHGLSPDSAERVIIPAAISGPQPPFPCLVAGIGTYEHGQTFTKEHFHYKCNNGTAEVIEIGNERYYSNYYYLTACVADDKSVIHLGRMFIRAGVKHKCDVKGDTMEMLDENKSTCYDNGIHYDVGEHFRNGSFVLVCQKDGITIEGCYARNTDITIPIGTERILDHYLHKCELLDQGRVRYTANLIGCKKDNEFFNEGQIWTTEHIRYQCTSYGIVRVLGCVDDNGLFIELGRDILIRNIVHRCYRIDKTTVYHRFACAGRTIAECILTSPLQRPSLDSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ37</accession>
    <name>A0A183GZ37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PKS_AT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS497</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000167">
        <property type="protein sequence ID" value="VDO25993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ37"/>
    <dbReference type="STRING" id="387005.A0A183GZ37"/>
    <dbReference type="WBParaSite" id="OFLC_0000049601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000049601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000049601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="374"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO25993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000049601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="78368" checksum="691597D7E1EDCC11" modified="2016-09-07" version="1">MFFKAINQFSPDLVILAGVHLLQNQNKEMRMEKLRLIKRSLLQIEHNIPIHFQVGNVGNPDHVAELLNRIVPHVDSLGLNEQELALLSNVGNGPHTNLYPTFPGAIHVHKVVEMLYWLITKFGHDSSDPQSKNYKYRLSRIHFHSLTFHLMVYKGADWSNLAAGLVAGAKVAALQSCKITNDFDMDNLELRTSKAQLLDKEIGKQYVFEPQRPLASWMRNDVIFIYTPALICKFPTRTVGIGDSVSTAGLIYSHLSAYVDSRIVRLSICEMAFFRKHVMLDSLKLIRLNKRNTSSSKDEPVKWLDDAATYADVQTSFVDPCTSLPYPEKELHRFLENKTPKIVEKVDNKTDDRRRNAWKLDFSHIPIEEQVVVLFPGQGAQYVGIGKKVMDCGRAIDVYKKASEILQYDLLKLCLEGPKSKLDQTVYCQPAVFVSSLAAWEKAKTEDETLNGRTTDVAGFSVGEFAALVLSEVLSFEDGKLKNFYTALRLIKIRAEAMQECSLRQHSGMITVRVNAATRLEEALEDAKTYASEKEELPICEVANYLFCGVKVIGASESCIDFLNNNQEKYVFQVIKRLAVNSAFHTILMKNAADTLKNALKDIKINEQPRTNVYSNYTGKLHIYKEKQIREAIVKQVYSPVKWEQIQQLLHAKHKDFKFPTFMEVGPGKQLGAILLKISKKAYKNYVSCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ61</accession>
    <name>A0A183GZ61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS521</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000179">
        <property type="protein sequence ID" value="VDO26080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ61"/>
    <dbReference type="STRING" id="387005.A0A183GZ61"/>
    <dbReference type="WBParaSite" id="OFLC_0000052001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000052001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000052001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="185"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000052001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35367" checksum="A78CC0608CAF330F" modified="2016-09-07" version="1">MLLWLFSSVYRPDFLTTYPKEDLECSLCPPVDEDDSSHLFIIDLTTPCTKLSSENPGEHDSSDNSYGTDKQNSSSEFVKENCGNDSKLECSSTQVVNNDGVIDVVENYSDLLDEGDVDLDLIVRDECYETHEDALEPYRSNSVPLLKKEGTSTHKRACSIELYKYKRPETVICAESVEIEYLMHRAQFFLARACEENIKLAMETSLWTTHPLIEKLLAEAYRRAPVVILVFLARNADHFAGFARMCSEALYRSQPAMRWVDFKGGGNIKLQWITKCPLALSASDHIKNPFNKGISHNICFLLNSCQKILLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZF9</accession>
    <name>A0A183GZF9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS619</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Oligomer composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000218">
        <property type="protein sequence ID" value="VDO26429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZF9"/>
    <dbReference type="STRING" id="387005.A0A183GZF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000061801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000061801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000061801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000067">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="12"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="487"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="674"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO26429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000061801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="746" mass="84183" checksum="0506CC4BAF399C06" modified="2016-09-07" version="1">MANPVPNPAECGIQVFCRVRPLNSMEEKGESKFVPKFPSDSQEAISVAGKVYVFDKVFKPTSKQEEVYMGAAYHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVFGDSEKQGIIPRIVQDIFNHIYNMDVDLEFHIKVSYFEIYNEKIRDLLDVTKMNLAIHEDKNRVPYVKGATERFVSSPEEVMACIDEGKSNRHVAVTNMNEHSSRSHSVFLIQVKQENTATQKKLTGKLYLVDLAGSEKVSKTGAEGTVLEEAKNINKSLSALGNVIAALAEGTKAHVPYRDSKLTRILQESLGGNSRTTIVICCSPASVNEAETKSTLMFGQRAKTIKNVVVVNEELTAEEWKRRYEREKEKVARLKQQLMAAEAELSRWRKGEKVPEAEWVNLLEGAAVNLQLPSGAESLSPSVSDSVLGSLDRSISVAPVPLLTSAIGAITDADRKKYEEERLNIDFESSRIPCFLNCTFFKFIQNMWDISALYIFYLQLDEKDDEITLHSQLAERLKQQMNEQEELIRQIKLDYENAQAEVSRIQSENEASKEESKEVLTALEELAMNYDIKTQEAEQKTRENEQLSDELSKKNVKVLELTTELETLRESCATQKKRITDAMQSMLRDLSEVGSNYANAAKFNAENGIDKPYDEELFAHARIYLLYALFQKMSSLESGSGDVTHRLETTEKELADCRLLLQQNEAKNKSLQETIAVQEKMKRQLEEQVNSLISSKNFVFTEISEILLILFICGEFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZP9</accession>
    <name>A0A183GZP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vezatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS706</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000260">
        <property type="protein sequence ID" value="VDO26771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZP9"/>
    <dbReference type="STRING" id="387005.A0A183GZP9"/>
    <dbReference type="WBParaSite" id="OFLC_0000070801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000070801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000070801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000070801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56545" checksum="E0DEE7F23842059E" modified="2016-09-07" version="1">MHCCSVARSFTNLCYIGLHRCLGMSSSGFFCLVYELLLEKSLFDDMDLEMVEEYYLKSERKTLISFKCVSCILVIAVVITSGFFAFHQVLGFLVCSALFICLLEATKQFCYYIVSSYVNVSVDFDSVSHQTVAVIRSREITFFGLRNKLDINATVCLRSLRLELLKSLRCEVQCHVRMSRNLCRYDNSQKLLCAMFTSEMSRLALKDDICEKFLQLSALKELWQLLFLLRSEYLRLFLLHLSRPSHRLILAFLYLLQEILVLRNNKASLEFINYRNYCVAEKKIPKISSFLSTTDKILAYLSFASEVKAIELSAPETRIEYEDIKHSNISSNSSISGSTDEAESIADELSIEKVYEGSSLASDDHQKDMLRSSWQENESNKAVARSVVVELKARLVERMRERNAAKTTKIDHTQRMITVEDEFREIPTVDESCNYEKYLTEKATNQDNLNTLTSLSKRNDKFQSCAELDLQQAILFRKLAPSVDFIDGPGNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZQ7</accession>
    <name>A0A183GZQ7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoribonuclease MBLAC1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS717</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68096"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:68097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000266">
        <property type="protein sequence ID" value="VDO26817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000071601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000071601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000071601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07711">
        <property type="entry name" value="MBLAC1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552324" description="Metallo-beta-lactamase domain-containing protein 1" evidence="7">
        <location>
            <begin position="23"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="8">
        <location>
            <begin position="335"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO26817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000071601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58864" checksum="CC1402E26F3C769B" modified="2016-09-07" version="1">MPSIISPLLAVLSLLIIRSVVLEENHRDRLKLLESLNDSSVNWLHDFVRRGKGSVSKLPFEEIFIGQSDSDAISIPTVTSTWNEIAEANANIVQIGGDFNMAIGSGSKALSISSDAPKKSTKSRIILSATTMSSSPTATFTSRIVTTKTEANSSQLKNVSEKMEFDFKRLAWLLQQAIDRRKTKKNQVTKDNEMKQNIRLKNDSLLGEKIRSSFQQHTFSVSDLRPIQLFYHHVNPDRRSESNDAISRNLETKEAKKMYENGNHFAGNEALKRSNRYPHRILGPILITQRKKENYMVPSQAALSASETHANDDPMIYIIREGSIVQSKENDYEFVSSITLIIDGGEKILVDTGLATDINGRAWILQRLSELGAPPPSINYVITTHGHPDHSGNTNHFPDALHYAGKFIHFGTHFNFSRIPEDNVKKLTKNVYLLKTPGHASDDISVLINNTSFFGTVIVSGDVFIRKEDMKYSTIWKQLTVNETQQQESRKRLLCLADCIIPGHGPLFRVTSNKKRELNCPGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H027</accession>
    <name>A0A183H027_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000334">
        <property type="protein sequence ID" value="VDO27275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H027"/>
    <dbReference type="STRING" id="387005.A0A183H027"/>
    <dbReference type="WBParaSite" id="OFLC_0000083601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000083601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000083601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000083601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20633" checksum="F45D9FFA163A3976" modified="2016-09-07" version="1">MTMDSASSSTPAESSSFEQRFHDRMKVLNFTKQKLDFEMEKLCVRSHSQPLNYIHSILSNAKISDLEKPVSRNYQESGHETQRFQEDSSITKTDPVHEKMVEMEESVVRTIPNIEKYLFPLFLYVIQNVEVEMKNNSLEKHAVDPLMVRYMKMIEDQREKVESVIEQTPKKEDVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0S7</accession>
    <name>A0A183H0S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1087</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000466">
        <property type="protein sequence ID" value="VDO28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0S7"/>
    <dbReference type="STRING" id="387005.A0A183H0S7"/>
    <dbReference type="WBParaSite" id="OFLC_0000108601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000108601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000108601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000108601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21531" checksum="7B9FBCC483C6972C" modified="2016-09-07" version="1">MFLFTVKISITGMFDLPLLNLAEVLAVYGSFCGLLYVGTDGFYREAPFLNSMPTLSLTILTLTLRVKGIIKLLTSLTFLVLALGVYLYSSQWHNNLQTVCALFTIAHISYILSFILSLRRLWFGCAVVVITYVVAFLYFCFVDLFWSIPILVLNFCLLFMTLAISLISAGSIWHYGSKRGNAEQQVCGFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0V3</accession>
    <name>A0A183H0V3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="2">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1113</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000478">
        <property type="protein sequence ID" value="VDO28294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0V3"/>
    <dbReference type="STRING" id="387005.A0A183H0V3"/>
    <dbReference type="WBParaSite" id="OFLC_0000111201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000111201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000111201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000003">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF23">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="10">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="9">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO28294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000111201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36874" checksum="37DA7D988BDFE10F" modified="2016-09-07" version="1">MVGVGGLTFTVLPWCLSFRRKLVIDEARDCKCHRLAVSLNETLNSLNFETNFRKAVQSLTSEECAKAARFRFKDDTLASILGRLFLRQATRRLSNVEWSTIEFGRTEKGKPYLMSPSNTKYGFNVSHQGDYVAFASSCSLRVGVDCMRLDKERNNKSADDYITSMAKSAGPEELRMMRSQATDQMKMIYFYRYWCLKEAVLKATGEGLLQDLSRLNFHIEQRERYRPRCFITSTTVSLDGELQDEWILEETFIDEMHNVAVCREKRLPSHCVYSTNPDTRIYFGFVDISFLLEGAATLNPLPEDGVVEWMNFNAKPRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H142</accession>
    <name>A0A183H142_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1202</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000530">
        <property type="protein sequence ID" value="VDO28640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H142"/>
    <dbReference type="STRING" id="387005.A0A183H142"/>
    <dbReference type="WBParaSite" id="OFLC_0000120101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000120101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000120101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001371">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="89"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="313"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO28640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000120101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="560" mass="61853" checksum="F949CE3B8E070E0A" modified="2016-09-07" version="1">MFGGKICAIFLHLRILVESEYTVSFERIVKLLFLAGLLFLVVGNAIGLVLPRIIFMFIDINNNHENEENMRENKSGDKNIYFMLAANRNKVGEIVSRLSTDALIVGQSVSSNLTVGARAFMSFFGSAVIMVYTSPELSKVVTCLTAAIVTSGYCFGNLQRKYTLQMQEAVAASNEVATEKFSNIITVRTLVSELKECETYKKKIHQLWLVSRREGRAAGCMIALHEIAILASLYTIVHYGGQLMNIGTLTYGDLLAFIWYASLCALSLPGMVNFYTELMKGLGASTRLFELRNRIPEVPVRGGLLKKDIIDGIIFKNVSFGYPNRPLLFTDVSFYIPAGKTTALVGPSGSGKSTIANLILRLFDSNSGQILIDNVDLKSIDPSFWRQQIGTVAQEPILFSTTIRNNIIYGSKHPELIMDIQLEEASNLANALNFIKNLPDGFETIVGEHGTSMLSGGQRQRIAIARALINDPMMLIMDEATSALDATSEDLVRKAILTLIKSSKKTVLIIAHRLSTIKYADQIVVINSGRVDEVGTFDELMLIENGVFKNLVEKQAIGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Q0</accession>
    <name>A0A183H1Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000655">
        <property type="protein sequence ID" value="VDO29434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Q0"/>
    <dbReference type="STRING" id="387005.A0A183H1Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0000140901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000140901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000140901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000140901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="671" mass="72614" checksum="F23E87E7B39F4C8B" modified="2016-09-07" version="1">MVEEPTDMIVLSVQQAVEMIHGLIDDSECNVEEVIQRVSNIHNFSASQNEENGNRSNPALTNAMAATATPLFQKKSHAIGTASSVFFSLLQMSHTATAGKKALPYTSTTNVWAQRAAQRQSQKVVSAIGSEKKQKMSSSATEQENTIPDQALNLPGIVHSVQEVPVIDTAAAVVKIGDEMQRHGVKEFCRAPGHARPTSASASSPSVSPIGLKSSIHVGAGSTVVVSTVGTAMPTATVTDIKPGTELFETEPKIEFPQNIPIIAPLSTASDIAERKMQPLLGTTKTNLDALKTSSINEKLFSSLDSSRPSIMSSSIANIWDDNIVDDKPWVVPTPLTPMQLQDFARNISVQLPTSEKPTRNYSNTNSTTDHVVDLAKNIANLRTSEDRPAATDDEALARRAFLGENVPPFDLNVPFSNRDPVDWTNAGPFPTDTFARWRNGHLNSAPVTSSTQEIDSSSWIDQASVAARLASTRQEHLPFSPTTSYAVPGSSEHVTSSFGTDIANVNLNQQQQSTQAWNRMHFQQAAQAASNEFENLTNLLSSYRPTTSSQHQPVPSQQQQQQQPPQPIMPIGNINYNAAAAAVGSTSFRIPAPRSQIANTSVPPPPFFNSQIPPPSSMSHRSGIPVTQSIANATWPSVNFGEQAQTNTIAESTQFPQYSSTLRGNWNYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Q3</accession>
    <name>A0A183H2Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1763</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000892">
        <property type="protein sequence ID" value="VDO30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Q3"/>
    <dbReference type="WBParaSite" id="OFLC_0000176201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000176201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000176201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000176201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9073" checksum="0A295787566625D0" modified="2016-09-07" version="1">MQYHHIRLVVTSLGMGKGGGGGKQGESNRYTHHFAIMLRKVVHICSFMRGCMCVGEKCAFVGVCAWAECVVGACTWARYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Y0</accession>
    <name>A0A183H2Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000950">
        <property type="protein sequence ID" value="VDO30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Y0"/>
    <dbReference type="WBParaSite" id="OFLC_0000183901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000183901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000183901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000183901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35478" checksum="1F421B166128A84C" modified="2016-09-07" version="1">MSYCAFYPESLLEISQLPERFFNEGFLDIRLAAAGTLNEKSDKEGQCQSLGSHGFGNISYTSNQLSPGNNDIVTATSAEERTIGRNAFSNDSLAEIQKTQNPFSDECKQAIINQTFSMNPELAEIRISTNQLPTLLSYRSGIVEHPRISDRAELVDKQHALLNSPEQPYTYRTFGTEKLANSRNIPDQIIYQEGNLLSPSTNTINRNLYGTESVTDIASIPEQFYSKSFESFRNMRSDWRNRETSLRNNLQVVNRYAFGKQSLTDINDIGNQFPMKHHDKNYPSEVPRNALYRTLTDMKAISDPFAPKGILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3X3</accession>
    <name>A0A183H3X3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2183</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001201">
        <property type="protein sequence ID" value="VDO32151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3X3"/>
    <dbReference type="STRING" id="387005.A0A183H3X3"/>
    <dbReference type="WBParaSite" id="OFLC_0000218201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000218201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000218201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000218201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26783" checksum="B5AFA459C9D17DFF" modified="2016-09-07" version="1">MLDRSLSPGNLRPADESDCWAAFETLVTKLLASVAQHEQFQVKVTDMGGIVTGSSGGALRGSQALRFFQTHQIRCNLKRHPTCKDLKEWRHGHGSIKVDPFTSIAAIERYLLDHGIGYVRAEDSSGDEDGSDDDEMPSEGSVSGGSSQPSRIEILINDEKIPGHMSILQALRQFGQVNLGDNMDHFAVATGIWVNTHTLYYRAAASLSSEAPQELATATSTAKSSSAKSEKREKRPKIDEKLWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H489</accession>
    <name>A0A183H489_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleavage and polyadenylation specificity factor subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2299</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001291">
        <property type="protein sequence ID" value="VDO32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H489"/>
    <dbReference type="STRING" id="387005.A0A183H489"/>
    <dbReference type="WBParaSite" id="OFLC_0000229801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000229801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000229801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057951">
        <property type="entry name" value="CPSF6/7_RSLD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25524">
        <property type="entry name" value="RSLD_CPSF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSF6/7 RSLD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000229801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29228" checksum="AA8A2AA6CC4AEAD6" modified="2016-09-07" version="1">PNQQPPQLRGPPPTSQPLPLGALSVTRPPVNLSAPPPNMPQVQLSAGAPPPGAPPMNRPPPGFGQPPQALPPMSSAGPTGPSSTSQPVTGMAPPGAPPTSHPPPSFPPPGAHINPQVYRQNYGGGIYFISYNDISIGTIEGVSEAEFEEIMNRNRTVSSSAITRAVSDAAANDYASAIETLVTAISLIRQSRVANDDRCKVLISSLQDTLNGIESKSYNSSSRKHRSNRDRSRSPSERSRKRHRRSSRSRSRSRERYDYSPRHSSSSGRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4S7</accession>
    <name>A0A183H4S7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2487</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01001438">
        <property type="protein sequence ID" value="VDO33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4S7"/>
    <dbReference type="STRING" id="387005.A0A183H4S7"/>
    <dbReference type="WBParaSite" id="OFLC_0000248601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000248601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000248601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000248601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44663" checksum="83C2F43B7118D674" modified="2016-09-07" version="1">MGLGTNSGERNIDGRRKGRWDAARIRRDLGSVRQIRHLSLLFYTSLSLSRLRYHWGHILKGFCIAASCCVVEDIFATPYSYLILLIRNRLLGHATPPMYGDYEAQRHWMEITYHLPVNQYINGSDNDLNYWGLDYPPLTAYHSWLLGSIANKLNRSWVELHISRGIETESHKIFMRITVLVTYWTIYISSLLLSIGFFRYTLSQKMLNYCAVAVLYPGLLVMDSGHFQYNHVSLGLFLFSFACFVSSFLKLGSVFFVLALNFKQMELYHALPIAIYLLSRSFPSKNQLSTREEDELDFSLILCSCRYLSWAKQLFVLFITVTITFLFVWLPFLVTKSDLIQILHRIFPFYRGIFEDKVANFWCAVNTLYKLKSNFEIMVLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5F2</accession>
    <name>A0A183H5F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2711</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001621">
        <property type="protein sequence ID" value="VDO33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5F2"/>
    <dbReference type="STRING" id="387005.A0A183H5F2"/>
    <dbReference type="WBParaSite" id="OFLC_0000271101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000271101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000271101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000271101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9479" checksum="F2914F43CA608DBF" modified="2016-09-07" version="1">MWSKSSNIPPMMHQPPPNVIPNSVGMNLSGVDHYQTPSARIQTQQPNVHPHGLMQQQIKVFLLIHLAVSLSVTVLIGVQSPLISYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5K9</accession>
    <name>A0A183H5K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001674">
        <property type="protein sequence ID" value="VDO34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5K9"/>
    <dbReference type="WBParaSite" id="OFLC_0000276801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000276801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000276801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000276801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7806" checksum="12CEB832B86752A9" modified="2016-09-07" version="1">MGYCLFAALACITVLWYYLLFSSLILTGRSYLYSGNVNILLKAHADSLYNEQYNCQTVINSSANNVKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7P0</accession>
    <name>A0A183H7P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3502</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002352">
        <property type="protein sequence ID" value="VDO36746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7P0"/>
    <dbReference type="WBParaSite" id="OFLC_0000350101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000350101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000350101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000350101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="3927" checksum="B264E9459ACFA99E" modified="2016-09-07" version="1">MVMGTGMGEDINCSVPEVPLAHLEDDIDSIKAVPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9V8</accession>
    <name>A0A183H9V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4270</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003171">
        <property type="protein sequence ID" value="VDO39479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9V8"/>
    <dbReference type="STRING" id="387005.A0A183H9V8"/>
    <dbReference type="WBParaSite" id="OFLC_0000426901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000426901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000426901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO39479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000426901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16965" checksum="67DA1D290D3F1D27" modified="2016-09-07" version="1">MDDEAENLLIASETSDPYATMLINPKTGVARWSYKGNELQGAVTGSVEMLGSNRFIVVTKDKPLLHLLSMDNNKRLHVKNVLPKPVRHLAVTPDDRVLFAAVDNQIYIWIIATGELTAIINSHYRSISSLLLNSDGSLLVSGTEDGSLCVFVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9W0</accession>
    <name>A0A183H9W0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS4269</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003170">
        <property type="protein sequence ID" value="VDO39478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9W0"/>
    <dbReference type="STRING" id="387005.A0A183H9W0"/>
    <dbReference type="WBParaSite" id="OFLC_0000427101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000427101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000427101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO39478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000427101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32109" checksum="FA594E5768932990" modified="2016-09-07" version="1">MSTNSQSDVRWSGSNNRFHSKRSSQNRSNIEEVETTFKRSYPDANSIYPPFCRKLDLNIPDYIPEGDVEFPFENIDDVGDENKIRGNWSSRMDYLLSAVGFIFNLGNLWRFPYYCRMNGGGSFCFCYIILMLIAGLPVLLMELTLGQFPSTGCFSVWKAVPLFKGVGIAMFMVSCIVCIYHSVVAAWAVFYFINSFKSALPWATCSNKWNSIIWNRDSVASCFLQNGTLLRNGSCLIDKEYLSGNSSILEIESFDIDEHVLPSADYLQVHLEHEHLDYADMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9Z1</accession>
    <name>A0A183H9Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003210">
        <property type="protein sequence ID" value="VDO39569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9Z1"/>
    <dbReference type="WBParaSite" id="OFLC_0000430201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000430201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000430201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000430201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13035" checksum="B5619FBC7FB60561" modified="2016-09-07" version="1">MRRDCSEFRHFCIQIKGFGFVDSVNKEQEVTTSQSSCLILVKMMILKKIFDVIDFGADTTAEITNSSFGLYLDEQDGNIKKYKSQEIEERIVFPVSDNHRQEINESLRLKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA68</accession>
    <name>A0A183HA68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4380</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003296">
        <property type="protein sequence ID" value="VDO39806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA68"/>
    <dbReference type="STRING" id="387005.A0A183HA68"/>
    <dbReference type="WBParaSite" id="OFLC_0000437901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000437901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000437901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000437901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="849" mass="95945" checksum="3F9000F159DEB015" modified="2016-09-07" version="1">MLASLRYDIEPDYATIVFEDVSHRTDHTINELELIDFLTKLREEAAIAALNKLSSLDMNGDEAVSFSELLQGYEKQLKKSVLKKVFSKVDVNKNAHIDPIEFVSLQNLIADKIHLQTIQNDSEQRYSTTTDTTTSLPTLIIFRTPKKPHNKLSSRRRIRRSDSETDKKLMGDDSQPGIKELISNNVYFTTAATAVPRFMESNDKYQKFISNGARLFDTLTDSKHKEEIKRDDIQKTWEKLISGISGSSPSIVQENHKLISNVNKGQMGSSSTTDKNGYAQEQNGALSNNPSVAYMKKFEKFFDFLEKAFKKVSAAVKENDEKQNNEKQAQFSESPLKSINIFKHMSPIDSISNTGPNEIEKTTNVTEIPIFAPTTTTKKMRKRGNRKNANYKKNRNEENLIVHTPVDTSKYKTVASEKFIGLFDAPSLQLDNEIVQETKEVKMIAYGANSREGQERSTEESDQEKIVDEDDCTLENVTTLRSDSSDSDDASEQKNRPIKKNKCIIQAQRSNEATDIEPLQKAPKVKKAKSNKKSKNQKKGRRKLEGKSSSKADSLEHETTPAFLDDVEKENNLFKMENKSSSISHKINSEKNNDELTEMFPEAEGEEESGELSDERASTKHIHFNESSEQESADKNAKSTMQHFDSELNEKSINLTDKPIHSGSDSTNIEKIPAKTKENKLLSHKTVHLKEYKLVDESGLPEKESRNNQFSEPNFMFSIKENITEKNAQEMYLHSKTADSQLLKSQNSSSEQMEWETVSGEYQDILNNSTEDKVSDEAINRILNAVFSKIYQTSMASKIEKSGNQIRMMDSKKRKSTMNSCSTTTNPCSTTTNPCSTTTNPCSTTTDPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBT3</accession>
    <name>A0A183HBT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovate family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4946</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004013">
        <property type="protein sequence ID" value="VDO41537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBT3"/>
    <dbReference type="STRING" id="387005.A0A183HBT3"/>
    <dbReference type="WBParaSite" id="OFLC_0000494401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000494401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000494401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000494401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20932" checksum="5CC1299EFA7B5525" modified="2016-09-07" version="1">MGRKYYKSVLGPYRQLTDDKETNDRRSTWLGPSMIPQLCVAPRMIPGPAPIPAAELSAPASAPKSAQASKQSFPSIYPERVATSWWCPPVYQKSQPKNSISPAVINPQVPQNPQALNYPQILYYPQIPHYPPILHYPQVPPYPQNPYNFFIPQQNGEFTGSSLHEMIAEDPKPAVKEFNPIQTNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCA4</accession>
    <name>A0A183HCA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5116</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004230">
        <property type="protein sequence ID" value="VDO42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000511501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000511501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000511501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552488" evidence="2">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000511501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16238" checksum="7873D7EA410C35B1" modified="2016-09-07" version="1">MAYAYILIAAVSLINISLLSVHVSGIHPAISETPFYILYTKHKHKKTKPSFEIEVFFNDLILQLILNFCVIAIFIPHKSVIEIFLISKFPDSMGINLSLIPYHRLFYDITKRYFFKIFSVFRKVVNHYQKSIIRQKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCJ0</accession>
    <name>A0A183HCJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004342">
        <property type="protein sequence ID" value="VDO42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000520101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000520101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000520101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000520101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17026" checksum="718EA1FB40ECEEFE" modified="2016-09-07" version="1">MFAFDGWPPFMYVMHSSVSVSVCVYVRVCLYVCVCVYVYRYGSLVTGLYIPDGITYPPYCKRMNFREFVDDFRKDIVNGWRILADKSEMKFNWPVNCPIEVRELVGPERFDPQDPRFMMPFFWKKEPVPACRSWYNLHHFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDC4</accession>
    <name>A0A183HDC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5487</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004743">
        <property type="protein sequence ID" value="VDO43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDC4"/>
    <dbReference type="WBParaSite" id="OFLC_0000548501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000548501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000548501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000548501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13158" checksum="D2DFC007ACCA4DE3" modified="2016-09-07" version="1">MSSSYRKHLMKKSRNASVQTIFPAKNIVNVPNAISFDHATEEQSIIRGILKVLIYLKYGYLTHHKLREICKFQKSLFRIWKSKVMQPPNLEKFPNAESQIPSACNIFTPPSLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDW8</accession>
    <name>A0A183HDW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5680</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005012">
        <property type="protein sequence ID" value="VDO43944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDW8"/>
    <dbReference type="STRING" id="387005.A0A183HDW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000567901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000567901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000567901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO43944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000567901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18926" checksum="0C5E72979ECC5D7B" modified="2016-09-07" version="1">MQAAMSGMGSLAGYSFTQLTPTQLTPYAVATSSSAPVTTTTTSVLHQQQQQPVGSSLTTTAIMHLDGMTMKNELPGCSSVTSLQSENINDTSTYDAYATSESNEMEACASSIRSSVSPRSQEEHVFMGPFSGDSYDALEQEKKKLERKRARNRLAASKCRQKKLQKINDLEKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEA5</accession>
    <name>A0A183HEA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5819</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005212">
        <property type="protein sequence ID" value="VDO44448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEA5"/>
    <dbReference type="STRING" id="387005.A0A183HEA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000581601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000581601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000581601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Frizzled/Smoothened 7TM" evidence="3">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO44448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000581601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25660" checksum="24E9D574A3C09DEA" modified="2016-09-07" version="1">MNEIFLENNHDAMCMKGPASDEDGPLIVEEMESDLTKNMITSNRCAQQPNTIYMNRTGHCVPLCHSNNGYTKDDREAASTALFIISILCTALTAICLLTFCTRKHCLVGLPELSLLFCSISFSISAIVYLFSLLYRDQISCIEYNSKLISVVTGVQHIPCTIVAIILYYFGTTGRLWWFVLCCTWNKYTQRHQQNSVSLFSIFNYYGNFLIIIRQVHKIFNCILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFJ5</accession>
    <name>A0A183HFJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005842">
        <property type="protein sequence ID" value="VDO45934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000625601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000625601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000625601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000625601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12351" checksum="CEC603638F299027" modified="2016-09-07" version="1">MNNYLVRCNADMRRSASSVTSRPTPEPDVSEHFRRSLSGKWPRRQTNYGHYTPPFQIDVDKKISGDNLVHIRSLLHRKNQTIGLRNISSCSASSPQQIVVNNSGIESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG64</accession>
    <name>A0A183HG64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006174">
        <property type="protein sequence ID" value="VDO46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG64"/>
    <dbReference type="WBParaSite" id="OFLC_0000647501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000647501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000647501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000647501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21631" checksum="E73D64ED85A5F4EF" modified="2016-09-07" version="1">MRRSKDLGFSWSISEIEWKKKKLNEIMDINVGIDSKPRTRRGRRRFTDRLVTLASDHNDDINDLTGMIGVKPFVEIKLFSDPNITLNVRVKERGNNDTRKGPVGSIFKDTPAIAIKGLFRKEPSHELKDTIKRPLTGLFRTPISRVNSKHRSKNENKTEADIFVSETSNHRNEHIVSQSRKMRFFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGX6</accession>
    <name>A0A183HGX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6738</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006586">
        <property type="protein sequence ID" value="VDO47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGX6"/>
    <dbReference type="STRING" id="387005.A0A183HGX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000673701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000673701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000673701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1095">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000673701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="27387" checksum="C6ABD55594D6BE40" modified="2016-09-07" version="1">MWYQMFAIQNRLQIIQTRRRERRGWLFGQWRDDGIGDAGGNGAYGAPPAAVVPEYAPPAPPQSAKEVVVQTMRCMCQRGPPGPPGPPGDDGKDGRTGKSGNHGDPGRDGNIMPYTGLKTEPCIICMPGPAGPPGQPGNKGPPGPRGEAGQPGHDGKKGSRGMIGQPGPIGKLGEPGPRGKKGDDGKLVKIEGPAGVPGPQGPVGQPGMKGPKGNRGFSNPGPQGPPGEPGQKGKAGKKGPKGPPGPNGLHGIDGDCDHCPQPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGZ5</accession>
    <name>A0A183HGZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006615">
        <property type="protein sequence ID" value="VDO47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGZ5"/>
    <dbReference type="STRING" id="387005.A0A183HGZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000675601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000675601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000675601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1758" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000675601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15913" checksum="CA803608A28533D5" modified="2016-09-07" version="1">MLVAPLGTKIPIQCPTADVRVNIQTEDKEIITINGHVVEYLTQELQVIDLPNNEEFEDLISYRKQPDIMIGANYFFKFIDLQDKRELHFGYTLVQSKVGPMIVGSDYVDKLRNSKSHPSSIICSVCTNPNLDLENSGNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHT5</accession>
    <name>A0A183HHT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7049</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007102">
        <property type="protein sequence ID" value="VDO49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000704601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000704601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000704601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000704601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4346" checksum="8D1AD3F4D73CF56E" modified="2016-09-07" version="1">MRSFQVDTSLTVSNNMTLPEEVTKTLEQFYIEVCMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHU3</accession>
    <name>A0A183HHU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7055</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007111">
        <property type="protein sequence ID" value="VDO49100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000705401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000705401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000705401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000705401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9537" checksum="5E1182C4166E701E" modified="2016-09-07" version="1">MCRLGRFGELHASNELHAQWRFQSGMTVLPPNSNVTAILDDPRAKAASFWGRIAARINLIRNVLPISPGPSKKKIPSILLFTICII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHV3</accession>
    <name>A0A183HHV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SLC12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7064</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007126">
        <property type="protein sequence ID" value="VDO49147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000706401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000706401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000706401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000706401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11339" checksum="84C8A2EC24561CF3" modified="2016-09-07" version="1">MRTYDIWDASRESFKRRKRGERVDGQPVIFKQTTIDRLCTVYPNKEEHFSPRMLLVNVPGSIFFQQLKISTALHMILLQCISNFALIGERPILGCMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIF3</accession>
    <name>A0A183HIF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2110 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007453">
        <property type="protein sequence ID" value="VDO50090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000726401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000726401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000726401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000726401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10002" checksum="49E5901D0B47B770" modified="2016-09-07" version="1">MFDQNFARVFFHGKLLPLWYIISVDEDETVSDEVEKMKNLSRVVKAVGGIAVTVVETVQEGFVLGLKTEEGVACYYRSHCKVVAAVENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HII4</accession>
    <name>A0A183HII4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007510">
        <property type="protein sequence ID" value="VDO50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HII4"/>
    <dbReference type="STRING" id="387005.A0A183HII4"/>
    <dbReference type="WBParaSite" id="OFLC_0000729501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000729501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000729501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000729501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39355" checksum="7D77FAE3A935EA57" modified="2016-09-07" version="1">IFKNVIRNCPPVDKLKLERLASEEISVNSDKINEDGNKTIHSIRKRSVINNRSSLISPSQSVFWWAESGREEVSSKGFVEELIVTPNLWNKILKNESTAKNLKNLIIEIIEKQPKINVGRNEYDYRNEMEHGTTVPYSNRQIRSTKEENLETNPKSSATTTILSTTTTSLPTTTTISTDYTKTTIDLSLSKTTIDLSSIKTTTDLSSSSSSTPYEGTESLAEESEEEEIVEKNEQDEMREKNSDNDEKFKNSNNENNSSIVNLATKVMESGIIIDQRTTTEKNPEFDENEEFDDDDSNDCNTNCNLNEENTAATIMVESSGIIINDKFVIPEADSQEAIDYFDNERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJU0</accession>
    <name>A0A183HJU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RIBORED_LARGE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7753</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008295">
        <property type="protein sequence ID" value="VDO52412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJU0"/>
    <dbReference type="STRING" id="387005.A0A183HJU0"/>
    <dbReference type="WBParaSite" id="OFLC_0000775101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000775101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000775101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000035">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleotide reductase large subunit" evidence="3">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO52412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000775101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38749" checksum="974E45A87735ED71" modified="2016-09-07" version="1">MIIFQVTKVVVKNLNKVIDRNYYPVPEAERSNKRHRPIGIGVQGLADAFILMRYPFTSEKARDLNKRIFETMYYAALEASCELAKEQGPYESYEDSPVSKGILQFDMWNVTPTDQWDWATLREKISMYGIRNSVLLAPMPTASTAQILGNNESIEPYTSNVFTRNVLSGSFQIFNMHLMNDLMDLDLWNDDMKLEIIKNKGSVQNIERIPQEIRDLYKTVWEMSQRDIIDMAADRGAFIDQSQSLNIFLARPNYSSITSMHFYGWQKGLKTGMYYLRTRPAVDAVQFTVDKTLLKEYGNISADNDSKSGSSPDPGSANELTTKMMECRMSNGGDCLMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK33</accession>
    <name>A0A183HK33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008460">
        <property type="protein sequence ID" value="VDO52795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK33"/>
    <dbReference type="WBParaSite" id="OFLC_0000784401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000784401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000784401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000784401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18777" checksum="DAE60E46512C8E2D" modified="2016-09-07" version="1">MGFVPYGARSREEYAIQEEFSNNNGRGVFLMALIVPKDNGSVLQAEVLKEATENGFQAQLELFRAHQPLNERIYLNYPISKMYGQDFNIQINFNGIELKNDTLILDNTMNISSTEEINYAPFITNMISAKMITLRYHGERVGNWTVEQTQQYEMSIVRYFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL42</accession>
    <name>A0A183HL42_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8204</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01009095">
        <property type="protein sequence ID" value="VDO54551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL42"/>
    <dbReference type="STRING" id="387005.A0A183HL42"/>
    <dbReference type="WBParaSite" id="OFLC_0000820301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000820301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000820301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000820301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10542" checksum="95277BBD79C9525C" modified="2016-09-07" version="1">MGMSSPNRSAAASLGVQLRREQNYNTTDLLSYVKLNIPKLMFEQKGFCDQIVQIVSKEVGGIFFLDAPGGTGKKFLIKLILATNRSQNGIPLARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL67</accession>
    <name>A0A183HL67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein FAM174B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8231</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009144">
        <property type="protein sequence ID" value="VDO54683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL67"/>
    <dbReference type="STRING" id="387005.A0A183HL67"/>
    <dbReference type="WBParaSite" id="OFLC_0000822801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000822801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000822801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF15">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000822801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16622" checksum="5FEB1CA7F10E236A" modified="2016-09-07" version="1">MQSVHSIPASYCISTDTVKKERIEACTTLTLRLQLLISGIILTVITLCVIIVMTYRKNRSLEYKYMKLVEWKDNAKDLRLLGAESCGVEDDDNEDDGEDQDRIFFARKNRRLYREYKKERNLSHKGDREDSGQTPFVPLEQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLI8</accession>
    <name>A0A183HLI8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS8350</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="UZAJ01009354">
        <property type="protein sequence ID" value="VDO55219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLI8"/>
    <dbReference type="STRING" id="387005.A0A183HLI8"/>
    <dbReference type="WBParaSite" id="OFLC_0000834901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000834901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000834901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="15">
        <location>
            <begin position="33"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO55219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000834901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20430" checksum="4EFD2592E3C7025D" modified="2016-09-07" version="1">MDAINDLSLDDEAFSIDVDQDPILCRDEKLDTPDKEVRVHCGMLRSARYVLEILRANRILEGLKMKYPDFTIVCCGHSLGAGVATLLTLLLKQSFSPIQCFAFSPPGCVISENGLEETQKFVFSVYIGDDIVPRLSYQTVCKLKYDVIMSLACSNSPKYKILLRGLYRLCFSHPWQPDQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMP6</accession>
    <name>A0A183HMP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKcGMP_CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8759</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010163">
        <property type="protein sequence ID" value="VDO57253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMP6"/>
    <dbReference type="STRING" id="387005.A0A183HMP6"/>
    <dbReference type="WBParaSite" id="OFLC_0000875701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000875701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000875701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000875701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11899" checksum="510BAFE22A5015FF" modified="2016-09-07" version="1">MIGFFLFLRRREEAVELRAILATRFEQRAQASCSSRPDSDQCSDLRSDDDSCNDLDEELNLGRQCRQLKLHIQTLSRTIAEKNAEIERLEHRLNEFTSSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP82</accession>
    <name>A0A183HP82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRM1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011240">
        <property type="protein sequence ID" value="VDO59554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP82"/>
    <dbReference type="STRING" id="387005.A0A183HP82"/>
    <dbReference type="WBParaSite" id="OFLC_0000929301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000929301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000929301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000929301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="18144" checksum="2808988B0478A17A" modified="2016-09-07" version="1">KKKKFIGLLQWRKVCFKAKDREVLHFLCERLCIINASGLARITWNTFYQTLQNSLQEDNIGFREDAMHKLAFLLENTCPRLRSAMLSMENFKAITDAFVYNQTEVFALFLSYLEPEQLQLTREYIDRIYDRKKSEASRKQLRILLRRQQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPC7</accession>
    <name>A0A183HPC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cation_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9335</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011339">
        <property type="protein sequence ID" value="VDO59802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPC7"/>
    <dbReference type="STRING" id="387005.A0A183HPC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000933801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000933801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000933801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO59802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000933801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16241" checksum="B9D027AEA6D4E83A" modified="2016-09-07" version="1">MPPWKNIWLMSSIALSLSLHFVILYVEILATIFQITPLTIMEWFAVLKISFPVILLDEALKFIARNYIDGEAIYRTGDYEKPSRKRVLRILLTVVMLTMLYVGYFYWILKPYLPQLMHAIGKNSQSNLNSFPSHSRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPJ1</accession>
    <name>A0A183HPJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011482">
        <property type="protein sequence ID" value="VDO60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPJ1"/>
    <dbReference type="STRING" id="387005.A0A183HPJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000940201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000940201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000940201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000940201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11330" checksum="5620CDC4FF8B3413" modified="2016-09-07" version="1">MEFFESLPPFVRQNVIRNERNVVRSATIGLHLESLGFFNFNELKRMEENLDDNESYCNLRKAVMEIILQYSAENNPFYNDKRLFDVFCIAISHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPW5</accession>
    <name>A0A183HPW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011771">
        <property type="protein sequence ID" value="VDO61229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPW5"/>
    <dbReference type="STRING" id="387005.A0A183HPW5"/>
    <dbReference type="WBParaSite" id="OFLC_0000952601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000952601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000952601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000952601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6689" checksum="7D022CB81A2024B1" modified="2016-09-07" version="1">MESLLRSRRIRRSNSLPTSRITCLRPRNERSMRRKYNFAFFKYNQLIIQINRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPW7</accession>
    <name>A0A183HPW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9529</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011769">
        <property type="protein sequence ID" value="VDO61212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPW7"/>
    <dbReference type="STRING" id="387005.A0A183HPW7"/>
    <dbReference type="WBParaSite" id="OFLC_0000952801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000952801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000952801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524:SF5">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000952801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18103" checksum="A8FB55F553EC0A64" modified="2016-09-07" version="1">MHSSSELVEDLFEDLKDGVLLCHLIEVLTGEALPVNKTKESKRVHHISNLTTALTVLRRRGLDLVNNNPTDIANGNPRIICGLIWQMILHFQIENNVQLLKEWGFELELANSPSTSKIENGSSPFSKLPYQLHIGRLKAPVDRVILRWVNAQLARYFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC7</accession>
    <name>A0A183HQC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012158">
        <property type="protein sequence ID" value="VDO62489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC7"/>
    <dbReference type="STRING" id="387005.A0A183HQC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000968801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19284" checksum="0BBD0FC7E3F4D50F" modified="2016-09-07" version="1">DLSNTANRGSSTAISRSRRRFERLRRRRRSQRLMGLQLRHGTFDAFRHGYLSRMLLGIDRTRDTVNTLRGMLLERHRNISTTSFLNDTMTTNASSNSDAVIDLEESSTLGDDDVMVISESFEEMDSHRRNIDNHDIVIDDDAAQEQDVIVDGNNSRNAINTSIILDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR07</accession>
    <name>A0A183HR07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9919</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012682">
        <property type="protein sequence ID" value="VDO64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR07"/>
    <dbReference type="STRING" id="387005.A0A183HR07"/>
    <dbReference type="WBParaSite" id="OFLC_0000991801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000991801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000991801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000991801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15735" checksum="9D5F58005DC682FE" modified="2016-09-07" version="1">MSSVSIEQFLAACETWNLEEVHQAVESGFLVDTFDDDHVTGLQMAAATGNIGIVQYLLDRGADIEKTNQVGMTALHHAAKNGHANIVRILVQRGANYQKLTYVIQIISYGTHIFKFILKNINILCYFRYNVASSSLIVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR78</accession>
    <name>A0A183HR78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012843">
        <property type="protein sequence ID" value="VDO64958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR78"/>
    <dbReference type="WBParaSite" id="OFLC_0000998901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000998901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000998901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000998901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3916" checksum="79E7E328C713DC1C" modified="2016-09-07" version="1">MRKIRNSGHHCMQRLVVPISILFVFLSIMVLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRE7</accession>
    <name>A0A183HRE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS10056</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Postsynaptic cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013009">
        <property type="protein sequence ID" value="VDO65487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRE7"/>
    <dbReference type="STRING" id="387005.A0A183HRE7"/>
    <dbReference type="WBParaSite" id="OFLC_0001005801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001005801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001005801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO65487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001005801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14260" checksum="F8DAA0BDC1180520" modified="2016-09-07" version="1">MHGFDMITQKFTEAKCFWEENIWEDYKLKWDPREYGGIKDLHFPGDNSRIWRPDILLYNSADDNFDSTFKSNLLVYSTGEVNWIPPGILKFSCKLDITWFPFDDQICGLKNNYTRLMTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSC3</accession>
    <name>A0A183HSC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS10384</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013779">
        <property type="protein sequence ID" value="VDO68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSC3"/>
    <dbReference type="STRING" id="387005.A0A183HSC3"/>
    <dbReference type="WBParaSite" id="OFLC_0001038401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001038401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001038401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF1">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL SUBUNIT B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001038401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17462" checksum="440F4B117D50D81F" modified="2016-09-07" version="1">SGNAYIRCFYFTTAVATSTGNNPAPTNVVEYIYMTFSWMMGVFVFALLLGQINIVSNANRNREQFRQSMDQVLSECKRLGLSKNTIDRVRDWFIYTWQKQKTLDEKKLIEDLPLKLQTDLALSVHYNTLSKVQLFQVSFGEFFNLYSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT12</accession>
    <name>A0A183HT12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10628</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014375">
        <property type="protein sequence ID" value="VDO70055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT12"/>
    <dbReference type="WBParaSite" id="OFLC_0001062401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001062401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001062401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001062401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10963" checksum="54B4D1D8F864C4FD" modified="2016-09-07" version="1">MYDESLARIQKPTQETEQEQPIAYESELLANSEFKQKQGDNIACLSDGGDNITCLSGNNGKTIYLPDNSGDITYLSDSNDNIICLSVPSKTVNKLKVSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU25</accession>
    <name>A0A183HU25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clathrin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10989</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015299">
        <property type="protein sequence ID" value="VDO72916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU25"/>
    <dbReference type="STRING" id="387005.A0A183HU25"/>
    <dbReference type="WBParaSite" id="OFLC_0001098701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001098701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001098701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO72916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001098701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23806" checksum="0D3FF8C2A7C13ED2" modified="2016-09-07" version="1">MSQVKNDLTKLMEIDANLTIRLLIENVGSLPTEKVLTQLEMYPKLQMAYLNSLFERNEGEEFVDFAIKLYAENEPPLLLPFLRKTAVYDIAKAIDICEKKQYINEMVYLLGRSGNRMKALDLLVNKLGRIDSAIDFCRENDDCDLWNSLVDAAMKRPDHITELLNTAGKYINPLNIIEKVFFLSLHYSVFCSFSLACIISMNFFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU80</accession>
    <name>A0A183HU80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015429">
        <property type="protein sequence ID" value="VDO73365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU80"/>
    <dbReference type="STRING" id="387005.A0A183HU80"/>
    <dbReference type="WBParaSite" id="OFLC_0001104201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001104201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001104201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001104201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9521" checksum="DD2A043F9C160CF5" modified="2016-09-07" version="1">MFHTIVVTSIAPPSATPIHGTPSSASISPVINNAAVIETKGKIPDHENLLPLQSTGSTPVLNVGGVASIHTHQIYRTPSATSHLQPLSVPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUK1</accession>
    <name>A0A183HUK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11166</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015783">
        <property type="protein sequence ID" value="VDO74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUK1"/>
    <dbReference type="STRING" id="387005.A0A183HUK1"/>
    <dbReference type="WBParaSite" id="OFLC_0001116301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001116301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001116301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001116301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9345" checksum="3B7C6687AE378A90" modified="2016-09-07" version="1">MNPDLLKAVLLNDLRLLQACIEKGIDVNEVDENGTSPLHLASFYGYHPIVHALIDARARVDARDREWFTPLQRYVCLMVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUQ4</accession>
    <name>A0A183HUQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11216</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015923">
        <property type="protein sequence ID" value="VDO74831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUQ4"/>
    <dbReference type="STRING" id="387005.A0A183HUQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001121601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001121601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001121601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001121601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12281" checksum="6D964E6ABBA89C51" modified="2016-09-07" version="1">MGTIEEGEKIDHHYVLSPTDIENRDMVKEKTNDELENSDDNRQSIDMPVLPLLTFDLVRLDNAVDRLLQASRIRLIMRELSGCIAKEAIEYRNDPSNSKSLLDILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV62</accession>
    <name>A0A183HV62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11373</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016366">
        <property type="protein sequence ID" value="VDO75964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV62"/>
    <dbReference type="STRING" id="387005.A0A183HV62"/>
    <dbReference type="WBParaSite" id="OFLC_0001137401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001137401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001137401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052392">
        <property type="entry name" value="Kelch-BTB_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375:SF3">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001137401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21933" checksum="81EC82F6FDC28C59" modified="2016-09-07" version="1">VSPLINKRSALGAAVVYDRLYVCGGYDGISSLSSVEVFNPSTNRWTLTTAMNKQRSAAGIAVIDNYIYGNKKKCFAVIGGHDGMSIFNSVERFNVDSGEWQTVKSMCTKRCRLGAATVRGKIYVCGGYDGCQFLKSVEVYEPEKDEWSPLSPMHLKRSRVSLVSNAGVLYAIAGFVIIFIYFKKCAKQWNILNKLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVR6</accession>
    <name>A0A183HVR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11578</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016874">
        <property type="protein sequence ID" value="VDO77500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVR6"/>
    <dbReference type="STRING" id="387005.A0A183HVR6"/>
    <dbReference type="WBParaSite" id="OFLC_0001157801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001157801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001157801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001203">
        <property type="entry name" value="F-box/WD repeat-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO77500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001157801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10516" checksum="3CD964328081726C" modified="2016-09-07" version="1">MWDLRTGKCVQTLDWKLSEGHTGVVRCLQVDSWRIVSAADDRTIKVWNLHTGERLCTLHSHTDGVTCVQFSDQQIVSGSYDMTVKLWDFGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX77</accession>
    <name>A0A183HX77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymosin beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12090</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018315">
        <property type="protein sequence ID" value="VDO81823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX77"/>
    <dbReference type="STRING" id="387005.A0A183HX77"/>
    <dbReference type="WBParaSite" id="OFLC_0001208901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001208901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001208901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020149">
        <property type="entry name" value="Uncharacterised_C02F5.10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17309">
        <property type="entry name" value="DUF5356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001208901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8541" checksum="D3F7C662501F2F40" modified="2016-09-07" version="1">MSSTNEKDFEKKPKEKVVTEKKQMIEKIPENQKTKFGESLATCSDTEWDKADPAYASELINVEKKPMDSNGNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYB0</accession>
    <name>A0A183HYB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12472</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039850">
        <property type="protein sequence ID" value="VDP11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYB0"/>
    <dbReference type="WBParaSite" id="OFLC_0001247301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001247301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001247301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552675" evidence="3">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001247301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22334" checksum="30A04814AC7E4366" modified="2016-09-07" version="1">MLRTLTITFFAFTASCYAAVKCPPNERGETLTCAFACCKNNINNLDFQNYFCCELEDNQFVRETTSRTNRPQRFIAYGSNFQIDYTLLIIGLIVSIILSILCSFFCCLLCNGCWLHRRRNPQLYESVSDGGFYPLCCGFGIPMGTIVFSTHPPQFRDESELYGGSSASSYSNRGRVRFNEDGTPRGVLKSNPNSYPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYS1</accession>
    <name>A0A183HYS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12633</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039888">
        <property type="protein sequence ID" value="VDP11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYS1"/>
    <dbReference type="WBParaSite" id="OFLC_0001263401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001263401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001263401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="1182"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001263401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1317" mass="144771" checksum="CDA37C07A958BE25" modified="2016-09-07" version="1">MGPKELNSVQQELFEAVRRGDAQKVQTWLLSRRNKRPRTPLNFLRASTSHSAWLCSIVDPSNGYTVLHLAALLGHKEVVKILLSVDSQMVRIKDRRGCLPIHLAAWSGHVEVLQTLINAEPNTVDAVNNAKESPLHLSAQHGHGKVVTLLLAKHADPRMRNARAETALDVAARLGKANVCRLLICNCPELALQSASECITIDPGRSRHLAQVVYPLHAAARHGHIDCLQILCHSGFDLDYVTEEGSALHVAALFGKVEAVKLLLEQGINVDTRDGQGRTVLETLAEHENEKASDLTQVIQSRDGWSECRKLVEAYIQKQKDRQSDKINAENSIYLNLPFCAKYGSNPKDVVWKPIPETARLQTSQNLVQHGSSYGTDTTSNIGTHYPPPSIVADMVTLFDDGHDLDDISTLPLSTIRVESSGSESGSQPSSGQPEGFGAENSVSRFVVVLPSHRYRHTVQKNGIPLPRMGVGRTSLHSDSAAACSYQAPLAYDAWRSQRACPYDNVKSPSHPLLAYDNIPRNLVVYDNAPPPGHQRWQHACEQKSIGEAGCENISPPSCSITSDNTQIMLSVKPSCQRLPLLEKTSKPEPIPRKTRVHEASANKNSGHVIKSSSSNSSLYRAESPASIITFACSTLERSLSPGEPSSSIPSGTASSTQGRAPLALPEEVSMSASASILSIQNSPEGCPIEENIRRRHSRLLNDDHSIQDRSSATVALNSSCSVKTALANCVEIIATENEASRDNDHSELDHLPSPETTESLIHHFLCNQDNVKQRLSQSPTVSKRSQHTQKDTMSPSSTVGSDCTLASSCSVPIISHVSSTPPSVISLSQECNQLYKQSSVDDHSFSSMEVRLRTASSIPAHGNRNKEGCRLSVSSDGEQHRDELHSSIQASFTQSDKVSIRHSSLDESIEWKKISEIMESFGGAICRESVFTAHYEPKVAVYLRDRRSQALTLQLNGPQAVQNRQSFGFDTDKRYKQPRRVNVVAEWLNVSVGIPNPRANEIAEVLEGNGFDSIEHMQSTLDRAAMQEIGFDKSTQHQIGMYLENYPNISIPSANSFTYVSDWLHSLDLEDYLGHFVSGGLTSMLIVFAVDSTRKHLKVLGITKLGHQKRILNSLKKAKEERRQRAAERAAAAKEEEADSGQESRSTAQSSSSTQISRSVIIGGHQTEWQHSSNTLIESCISFSAHYLGSVEISNVEETEDSRRAMIKLKKGIREIAKVPHVLLEISVSGVRVLDAITKQLTVEHEIAQIQIVCQDERDLNCFAYISQDGDRHFCHVFCVLTADVATEIIITLGQAFEVCYRITNNSYGSAEPIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZH1</accession>
    <name>A0A183HZH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12883</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039963">
        <property type="protein sequence ID" value="VDP12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZH1"/>
    <dbReference type="WBParaSite" id="OFLC_0001288401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25005" checksum="F1304BFA126AAAB2" modified="2016-09-07" version="1">MCFWNALKFVNDSYSHSVDGLTFFAGFDMINISQFRLPCPPKASSCDCNCGFPLLPQLPQLPLPPPFTFPQFPAYPSGSYVTPNGGNARQVENGYLQQPSSYQTSSSVSNQPHPSYQGAGAHGYSVKQFEQQTGTSSGYATGPYGLDNGNFGDYSSTYSFPQIGQNYNRFGALPYQLPLSGTGQYIRGPLHNAPQSNIPNDSVAVTVGTTGIEYNLSPTTADYEKKTKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0E2</accession>
    <name>A0A183I0E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13204</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040087">
        <property type="protein sequence ID" value="VDP13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0E2"/>
    <dbReference type="STRING" id="387005.A0A183I0E2"/>
    <dbReference type="WBParaSite" id="OFLC_0001320501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001320501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001320501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001320501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22710" checksum="9B27DB1955D76E9D" modified="2016-09-07" version="1">MAKVIRNQWVYKKTGHWYRYLPRRNDISKEFDYEKHMAGPEHFAEKMETKPPKLWLVWIYRNYSEDPSYIKKKIEKLFGKDAEPGKMFVFKNTASQNAELWPLKHIIEIRALSFSNGEPTIDDVNALEVFPDGRCVVDKRLECEPSFLNMMNPHKQMSNSYLCSRLRSQYNKCQDIFETNVYTAKNITLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I207</accession>
    <name>A0A183I207_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040384">
        <property type="protein sequence ID" value="VDP14608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I207"/>
    <dbReference type="STRING" id="387005.A0A183I207"/>
    <dbReference type="WBParaSite" id="OFLC_0001377001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001377001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001377001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001377001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8811" checksum="9AD2DCA7B9F247E4" modified="2016-09-07" version="1">MNVSNWNDAVNNWKAFKMTLEGSQVMPLLDTNGPDFITDPYVDEKPNRREKETYHAILKMHAGTLESAASQQSLNTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I294</accession>
    <name>A0A183I294_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13856</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040434">
        <property type="protein sequence ID" value="VDP14828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I294"/>
    <dbReference type="STRING" id="387005.A0A183I294"/>
    <dbReference type="WBParaSite" id="OFLC_0001385701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001385701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001385701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001385701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12704" checksum="3E27B1A9A690B385" modified="2016-09-07" version="1">MDRKEVRHNDIQPETIRIREHLSAELQPDSLSPSSTGTLLVHPPKLLTEVHRQECTELSREECPSATSLPMHILQQYRDEEKVPMFLVKMWNILEDPEFQNIICWDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2L8</accession>
    <name>A0A183I2L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13980</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040512">
        <property type="protein sequence ID" value="VDP15177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2L8"/>
    <dbReference type="STRING" id="387005.A0A183I2L8"/>
    <dbReference type="WBParaSite" id="OFLC_0001398101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001398101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001398101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000011">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF245">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP15177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001398101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38235" checksum="DB9D3F4EE0E962C0" modified="2016-09-07" version="1">MGICQSQEEKTMMAKSKEIDREMVQGRAAQQNVVKLLLLGPGECGKSTILKQMRLLHTNGFTDEEINQQRTVIYNNIVQGMASILQGMKKLNIPFENSERDADARIVMDVVKSGNESEPLTPALIVALKNLWTDKGVCKDAYKRGNEFQMPESIAYFMDSIDRISFPDYKPTEQDILLSRIKTTGIVEVKFKMKNVDFRIFDVGGQRSERKKWIHCFEDVNAIIFIAAISQYDQMLFEDETTNRMIESLRLFESICNSRWFINTSIILFLNKKDLFAEKIKRVSIKIAFPDYNGPQTYDDSVRFIEEKFEALNANPEKTIYIHQTCATDTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Y4</accession>
    <name>A0A183I2Y4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(+) kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040595">
        <property type="protein sequence ID" value="VDP15480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Y4"/>
    <dbReference type="STRING" id="387005.A0A183I2Y4"/>
    <dbReference type="WBParaSite" id="OFLC_0001410401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001410401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001410401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF4">
        <property type="entry name" value="NAD(+) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001410401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36031" checksum="52E7FD164C91D6BC" modified="2016-09-07" version="1">MVAGETTINNNVLEYEEDSNNLCIKNSKRRGWNYEEMKKKHIEQQNYVLAMRQYLENRGIKVEVLTRSEYTVEVIAHADAVFSAGGDGTFLVAAQKIRDYRAVIGFNTDPMGSEGYLCITRKGTQPVGEVIDKLLKGECRLFLQSDCDAEYPLLALNDVFIGESHASRVSYYDVQIDDGPMVRQKSSGMIACTGTGSTSWNYNINRVSEQHIGELSSIMADMNLLAINPTDAITEEICKRFNEKLLFDPQCTTIAFTIRDPVFNATFPVGIKRGFAKRIRVRSRCTNAHIVLDGNVSIPFNSGTEVLLEIHESDALRSAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Z0</accession>
    <name>A0A183I2Z0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyadenylate-binding protein</fullName>
            <shortName evidence="7">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14102</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040599">
        <property type="protein sequence ID" value="VDP15495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Z0"/>
    <dbReference type="STRING" id="387005.A0A183I2Z0"/>
    <dbReference type="WBParaSite" id="OFLC_0001411001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001411001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001411001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000009">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000021">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000091">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000649">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="199"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="304"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="10">
        <location>
            <begin position="574"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP15495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001411001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="655" mass="72281" checksum="9445093EFDE7702D" modified="2016-09-07" version="1">MATVATSGAGMTPSYPMASLYVGDLHPDVTEAMLFEKFSSAGPVLSIRVCRDAITRRSLGYAYVNFQQPADAERALDTMNFDMMYGKPIRIMWSQRDPSMRRSGAGNIFIKNLDKSIDNKAIYDTFSMFGNILSCKVANDEESNSKGYGFVHFETEESAQKAIEKVNGMLLEGKKVYVGKFQPRTARLREMGETARRFTNVYIKNFADELDKETLEKLFSKYGKITSAAVMTDADGKSKGFGFVAFENPEDAEKAVTEMHEYELPGTERKLYVCRAQKKNERSAELKRRYEQQKVERMQRYQGVNLYVKNLDDTVNDDILKQSFEAYGKITSAKVMCDDNGRSKGFGFVCFEKPDEATKAVTEMNGKMMCTKPLYVALAQRKEDRKAQLASQYMQRLASIRMHNAGSMPGTVYTPGTGGFFVSSSLQNQRAFMPTATIPGAQMRGTTPRWNTIGAAAGFGVQSPYMIQSGGYGQAGRGGTRPSATSAAVTMRAQQGQYGPGQANATRGGPQAQRMTAGNAIVQNQGTRSQQMGGRQAQPGKPSQGQMMYSSYSAITGRPGQVQSQQNSIVIQGQEPLTAHMLAQALPQEQKQMLGERIYPLIERIYQGPDVGKITGMMLEMDNSELLMMLENEELLQSKVSEAASVLASSKGQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3L3</accession>
    <name>A0A183I3L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14326</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040769">
        <property type="protein sequence ID" value="VDP16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3L3"/>
    <dbReference type="STRING" id="387005.A0A183I3L3"/>
    <dbReference type="WBParaSite" id="OFLC_0001433301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001433301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001433301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="245"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001433301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52750" checksum="B0EF82A21704A903" modified="2016-09-07" version="1">MGNQVSKTDKKRVEMPQHAPMKIARKPQRTQETTNKLPYVMPRRHCYLKFLRLSRTKDYLLLEKEFIQRQGKRGSISEQQKKERKTVNALRGSPIALARIHELFLDEKHAVVVIEGNKREWYIPILSIVDKDLIRIGALVMVKAQGSLKNIPIAVVGVLQDNIDTSNSIINKLEKPPKESYDVGFNFKFKMYSGEGFQSLFTDLPLNFEVPLDIGGLEEQIQEIKETVELPLVHPEYYEEMGITPPKGVILFGEPGTGKTLLAKAVAHSTSATFIRATGADLIQKNSGEGSKLVRELFRMARESAPCIIFIDEIDAVGTKRFDTTCGGEREVQRTMLELLNQLDGFESRGDVKIIMATNRIDVLDPALIRPGRIDRKIELPRPDEKTKLKIFQIHTAGMKIAADVKFEKYAAELSLSGADCKAICTEAGMLALRAQRKFVCLEDFDKAMERVIMQKKNEPPEEFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3L4</accession>
    <name>A0A183I3L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 184a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14325</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040768">
        <property type="protein sequence ID" value="VDP16519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3L4"/>
    <dbReference type="STRING" id="387005.A0A183I3L4"/>
    <dbReference type="WBParaSite" id="OFLC_0001433401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001433401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001433401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP16519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001433401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24122" checksum="9862C8B26F491BEB" modified="2016-09-07" version="1">SGDQGYLYITIVYNVSVSLALYGLFLFYTATRDLLSPYRPVLKFLTVKSVIFLSFWQGFLLAVLGSTSAIDPIYDADGLEIISRGTVAAAWQNFFICVEMFFAAVALRYAFSISAYIDPNTVLNGNVGGRPVTLQSISSSLKETMNPKDIMQDAIHNFHPQYQQYTQHSNPTRPGTTEMASGDERRLAGSSSGQMRGGYSSMAHTGANGVSTPTTPPNTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Y8</accession>
    <name>A0A183I3Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14450</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040866">
        <property type="protein sequence ID" value="VDP17098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Y8"/>
    <dbReference type="STRING" id="387005.A0A183I3Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0001445801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001445801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001445801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001445801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37403" checksum="05AB8DF814D22401" modified="2016-09-07" version="1">FFPAEVKRVGDTVLGIATQCVQAKNVIKTTPQTLSNLCLKMNVKLGGVNSILLPAVRPRIFTEPVIFLGCDITHPPAGDSRKPSIAAVVGSMDAHPSRYAATVRVQAHRQEIISDLTYMARELLIQFYRSTRFKPTRIIIYRDGVSEGQFFNVLQYELRALRECCMLLEEDYQPGITFIAVQKRHHTRLFAVDKKDQVGKAFNIPPGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNQLSADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDREHDSGEGSQPSGTSEDTTLSNMARAVQVHPDANNVMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I401</accession>
    <name>A0A183I401_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14463</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040878">
        <property type="protein sequence ID" value="VDP17166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I401"/>
    <dbReference type="STRING" id="387005.A0A183I401"/>
    <dbReference type="WBParaSite" id="OFLC_0001447101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001447101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001447101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552756" evidence="2">
        <location>
            <begin position="18"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="471"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001447101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="611" mass="68508" checksum="6138964874B9714C" modified="2016-09-07" version="1">MTFRFAWFVLFISVCCAENDSLEGSGEGSGEEDLLSPGSLWQPSTIKEDSSGDGNDILEFTEIYPVKDGCGVDLLFLLDASGSLEKIYTQHINWTNQLIETLLLPDNDQVHIAMIQYAETPIIEFSLNTYRDLRDIISHIMTINFKSGGTKTGKALLAAKTELFSEEKGARKNASKIIILFTDGLSLDDPIKHAQHLREVEKVKIYTVSVGSDDFGPEISSIAGGKSNIFGLHEFPRLQKILIDDVEQTQTCESKEWEIPTATIKTIEEKITTMDSSPSSSRKETSMKLHMTSRIRTSTTTNPTSHKSLTKDNQLKYKGQKITARQVIVSQDQDAKLLEKDAGDKINDENIDEVPISIVNADEQFVESITVPQQSTFSKDRTKNGKESDNSITSKFTKKLQKEIPRAKVITSSSITEGQEISRLADFPNNKTTLAPRHVTAQRISTPIPRKLERTESARSIERSQGQCPREILFIVDSSGSVQRIYDQQKKYLLSLLHELHIGEGDQRVALIQFAGNSHQRVEWTFDTYKDMKDIAEAFSQVRHFTGTTYIGRALENSIDVLETRRQGIPTIVILVSDGFSQDDASRPAEEIRQMPNVDFYAVSMSDLHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4F1</accession>
    <name>A0A183I4F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041002">
        <property type="protein sequence ID" value="VDP17863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4F1"/>
    <dbReference type="STRING" id="387005.A0A183I4F1"/>
    <dbReference type="WBParaSite" id="OFLC_0001462101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001462101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001462101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001462101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="47911" checksum="FB62C9C353B31877" modified="2016-09-07" version="1">MKKSDESNSRPQEDSSLAVYGLRRFNMRQGISPSSSNVLNNGQEIEVPSSSRSMYQNGKILDSWHNAKDNASATYFYNHDDMERTKNDISLLRNVITSNYSSVAPGNSMNSSEANYNRADGATSQGLQKIVPCGYAPNRFPITITPTPRPCWPKTFYGNPAHAFSGTVTLPSTRIISASSSVTQPIPSTSGFNPLSANEQIVYPKSPSASDSNSGGRSQTLLIGLLRRFETGTNTPDILETERKKFSKNDSGSEFFCRKLSFPKHNSVKGCADGKHPQLGAFDKKESAVENANDKHNARLIWSLSKDKEVKNVRNKSSKSASSRVKPHMPKFLQSFCCCIRPEAAIKAKRQTLHPVPSTSTPQSLITQITKNSQNGTNVNGTTVNDSHGIDNYDDTGEYVPMIEYSINNGLLNIYMTELNVLLYCMDAYVRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4I6</accession>
    <name>A0A183I4I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041038">
        <property type="protein sequence ID" value="VDP18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4I6"/>
    <dbReference type="WBParaSite" id="OFLC_0001465901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001465901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001465901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001465901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="16243" checksum="D8F5EA05D0B66DCC" modified="2016-09-07" version="1">MVELVRQTDTDIKGEFRVQFRAQSKRGKSIEFFPAKWHELKHRVEYLPHYSEKLMELYRDEEFNPGQLNIEIRLAFALNDFNYIVSKVDLNPLLKLEPESKTDRRLKRMPFAEENDELCVYLNFYFNNFFLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4P9</accession>
    <name>A0A183I4P9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14711</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041114">
        <property type="protein sequence ID" value="VDP18362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4P9"/>
    <dbReference type="STRING" id="387005.A0A183I4P9"/>
    <dbReference type="WBParaSite" id="OFLC_0001472201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001472201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001472201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP18362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001472201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24186" checksum="8F1A1082E9DD043D" modified="2016-09-07" version="1">MLKFKNPFCSPFEIEKVESKKEKVAEFSYVPSTYCQLMDEMIGRKTRPWNVDRSSVRPVQTFALPDISREELMFSRLMESCAFKSTIAAVAGFGLGIVFGLFTASVDPQATMAIAADPTKILSRNFALQPTLKEMWLESKSRMRSYGKNFASIGFLFTGTECLVESYRARNDWKNGTLAGAIVGGLIGLRAGVKPAALGAAGFAAFSTVIDYYMKYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I533</accession>
    <name>A0A183I533_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ELM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS14845</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041274">
        <property type="protein sequence ID" value="VDP19181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I533"/>
    <dbReference type="STRING" id="387005.A0A183I533"/>
    <dbReference type="WBParaSite" id="OFLC_0001485601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001485601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001485601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="11">
        <location>
            <begin position="101"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP19181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001485601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44351" checksum="D5C8F8D0CBDFAAD4" modified="2016-09-07" version="1">MKSNGSNGSDGDTQDKFDIDQEIKEGSEELSRQDNDEVDENENIVDEENSDQTELQCTPRSSGDDEDTVVIEEDAPGPSDFNGDLPFYSADHAAFHLPTNLEIREGIDYQCPVQDWTTEDDYCDDTERETCVWRPTNLLEVAEINDYLSIALASFNIEQDRAMFILQSSDYNIEEAKHQLAKRRIKKEPWNEEDTTIFKQALQTYGKHFNRIKQLLPHKSIKEIINFYYDNKKKLNFRSIIDTFLEEHNPESSSSEDSDVDSREKQTNRCYNCEQTTNLRQMADLKLCNSCFTHFRNYHRHRLCLKPISHGENANKTTKCPRGMAELVERFVEFATEEKDATQSSSLNKNVIEMEDDDDLQIVNVIRPPEMGYVRILKYVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5E1</accession>
    <name>A0A183I5E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein heavy chain 7, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS14953</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041402">
        <property type="protein sequence ID" value="VDP19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5E1"/>
    <dbReference type="STRING" id="387005.A0A183I5E1"/>
    <dbReference type="WBParaSite" id="OFLC_0001496401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001496401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001496401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="13">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="12">
        <location>
            <begin position="172"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="14">
        <location>
            <begin position="532"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001496401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="622" mass="71449" checksum="323B68D95D6001F3" modified="2016-09-07" version="1">MSQIKEDAHRQGLMLDSPDELYKWFTAQVMRNLHVVFTMNPSGEGLRERSSTSPALFNRCVLNWFGDWTDSALYQVGMELTNTLDMARPEYQAPLTLPIVCDLLPSPVQYRHAIINTFVHVHNSVRKLNENEAKRGHRVMALTPRHFLDFIKHYINVFHEKRRDLEEEKLHLNIGLSKIRETEEQVLELQKSLTLKSSELETKKAAANAKLKEMLADQQRAEKEKLASEQLQKELAESLIEIEKKRAEVQEDLAQVEPAVDEAKQAVKGIKKGQLIEVRSMAAPPQPVRLTLESICLLLGENVGMDWKAIRGVMVKEDFMPRILNFDTDSISAETLKMMEKYIRNPDWDFDKVNRASSACGPMIKWMKAQLLYSDMLRKVEPLRNELERLEKDAKVKTTKGDDLKKTIAKLEQSIAAYKEEYAQLIGQAEAIKADLATVKEKVGRSTQLLGSLGSERDRWNGSCDGFSQQMDSLIGDALLSAAFLTYSGYYDQQLRDLLFHRWTAFVEQAEIKHRSDLARVEYLSSVDERLEWNKNGLPVDDLCAENAIMLHRFNRYPLIIDPSGQAINYLMKQFAGKNITKTSFLDDSFRLSFAPLRYEVCKADVSNFENNFLRQFLRFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5S2</accession>
    <name>A0A183I5S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MORN repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15084</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041586">
        <property type="protein sequence ID" value="VDP20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5S2"/>
    <dbReference type="STRING" id="387005.A0A183I5S2"/>
    <dbReference type="WBParaSite" id="OFLC_0001509501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001509501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001509501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001509501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20260" checksum="60069E7B28ACB382" modified="2016-09-07" version="1">MKCGENGYEIIGCYYMDKNGMKIDMKPGTTVEVDGTMHYCDNKNDNIQYYKKRIGCMKYGNKYEEGENFAKNHLRYECKNGIVDIVGCYVDETGRNFKIGESITDKHMLYSCYVENGQVKYDQHPCGLNGFPSCEVSQKQQIPIQVPTIPKPDSGFDAFSIARVGQVRTLALNSYKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6B7</accession>
    <name>A0A183I6B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15279</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041871">
        <property type="protein sequence ID" value="VDP21138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6B7"/>
    <dbReference type="WBParaSite" id="OFLC_0001529001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001529001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001529001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP21138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001529001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26286" checksum="BAE79AEB29D0D6DF" modified="2016-09-07" version="1">MENNTQNNTEWEIIYRNKLDYSLVTHAFAIPLAFIGLFAYGLSLYFIRKSPLYHNAFGNLCSAYFLFQIQTIGALLIWTVVRIFINMGLISLSWHIFSRIVFPLANSTLYAAIWMQFILAINRLWAISRPMTYDRVFSPKNARIIVVSFWLFSILITALYYNVECESYVEADFYSWSTLFGPCKHSFLIYIAMSLSDGFFFAILIVDAVASYHVIAYLKVYFNFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6S9</accession>
    <name>A0A183I6S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15442</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042153">
        <property type="protein sequence ID" value="VDP21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6S9"/>
    <dbReference type="STRING" id="387005.A0A183I6S9"/>
    <dbReference type="WBParaSite" id="OFLC_0001545201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001545201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001545201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF131">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001545201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48056" checksum="121FE240AAB004A2" modified="2016-09-07" version="1">MHLDTYILLGRNGNANRSQNLAIYAHSNLLAPKKESLEISHRAEVLREATKVLLRGDGLSEKERLPLELDLPTLQRLLPEVDVSYFVGNITDFLGEENPSIEECLPRPLPCDHTTKYRTFSGWCNNLKFPHYGNAFAPMRRLLDPVYEDGFDSPRIMSRNGRRQLPSARKVSNAVHAEAPVFHAVYTHMLMQMGQIIDHDFAHSPVSRGPGNTILDCSRCDSAKTVSIHCFPIPIESGDPYFPHLHDNGEPRCIAFTRSLLGQLTLGYRNQLDQLTSYIDASFIYGSTECEANKLRLFSQGLLNFTNLGFNREALPQGRQERDCRSQPRHPCFNAGDERSNEQPGLTVMHTLFLREHNRIAASLSRINNFWSDEKIYLETRRIMGAKIQHIVYNEWLPIVLGCEATARYDLVPRKTGYYKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V9</accession>
    <name>A0A183I6V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS15471</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042202">
        <property type="protein sequence ID" value="VDP22032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V9"/>
    <dbReference type="STRING" id="387005.A0A183I6V9"/>
    <dbReference type="WBParaSite" id="OFLC_0001548201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001548201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001548201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP22032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001548201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12771" checksum="B34AE89FE19C1A7A" modified="2016-09-07" version="1">MAPLLQIGLLVLFAIVIFAIIGLEFYSGIFHSACYNAHGEIENLSERPFPCSNKSAATGAYNCEVNGTVCLTQWIGPNYGITSFDNIAFAMITVFQCITMEGWTTVMYYVSRFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Y9</accession>
    <name>A0A183I6Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome biogenesis protein NSA2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15501</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042257">
        <property type="protein sequence ID" value="VDP22203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Y9"/>
    <dbReference type="STRING" id="387005.A0A183I6Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0001551201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001551201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001551201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP22203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001551201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27075" checksum="7F0B268F91539772" modified="2016-09-07" version="1">MPQNEHIELHRKRHGRRLDYEERLRKRNARAGHERSQYAKKIRGRKAKLYHKKRYAEKVEMRRLLRQHEEKKQTGTSEEPDKGVVPAYLLDRQQQTTGKVLSSMIKQKRKEKAGKYQVPIPAVKAVSDAEAFKVVKTGKTRRKGWKRMVTKVTFVGESFTRKPAKFERFIRPMGLRFKKAHVTHPELQTTFQLPIVGVKKNPSSSLYTSLGVITKGTIIEVRINTFQLNALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7D6</accession>
    <name>A0A183I7D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15649</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042539">
        <property type="protein sequence ID" value="VDP23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7D6"/>
    <dbReference type="WBParaSite" id="OFLC_0001566101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001566101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001566101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001566101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33443" checksum="B878015823E40DA3" modified="2016-09-07" version="1">MEMLQIDLSNAEAVSAACVYLADPHKLPIPTKDANANVSEEESNMNNEISQHNLDDEKINEQNQLCEQYQMDDMSISSDSDFEETLQNHFQYTPKKSKSDEKIQKNDSSSIVFTSPVAFNTENPKSNASFSEKENFSPNVTGNINVNSNRILNSEGRKRRITNSHFDASSPVEQFCESSLVASTPMSVKPDNARQRRLAMVNSAIRTKMNQSKQRTLLNLSVSSTDSMNTSSPLSPKDEARKREQGAIAKHIARIRTSTSRIGSSNETSPLVNSTSRYYSMRTSFGSNDSSNFSKLSPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7H3</accession>
    <name>A0A183I7H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042621">
        <property type="protein sequence ID" value="VDP23235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7H3"/>
    <dbReference type="STRING" id="387005.A0A183I7H3"/>
    <dbReference type="WBParaSite" id="OFLC_0001569801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001569801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001569801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001569801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="20611" checksum="73737F6F95921E7F" modified="2016-09-07" version="1">MDRPIVIHFDKLYFICCSSVQTINEGQSQPDCDLHGQQSASSSSVYCLASSPKLSFKSSTNASTSSPELPASTSSISSTPCSSLLPTTMASPVSPYHPENNQSIIGASNSMSGGTLALNNVTPSNDNNNNSNRDDISTSTNSITANIKNNNNQNRRKRDGCGNRLDAMVQKLANRQKEKEAVAAAGSASGSSGSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I826</accession>
    <name>A0A183I826_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15888</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043140">
        <property type="protein sequence ID" value="VDP24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I826"/>
    <dbReference type="STRING" id="387005.A0A183I826"/>
    <dbReference type="WBParaSite" id="OFLC_0001590101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001590101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001590101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001590101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13918" checksum="2E7687A999D8C379" modified="2016-09-07" version="1">MCSRTNAQIAELRNIYQQMYKSSLEKDLIGETSGHFKRLLVSLCNGGRDESMQTDALRANQITNHTIEKAIEAEFSGDVKDGLLAVVACAQNKPAYFATLLYNSMVVSCYRMIILPIKKKKIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UIY1</accession>
    <name>A0A3P7UIY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001103">
        <property type="protein sequence ID" value="VDO31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H3J0"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="328" mass="37828" checksum="12B822F0D27BBF7D" modified="2026-01-28" version="1">MEKVIRRKVLWLPISGRFARVSLLGVGLENDPTMLLSSFTGLIILMVPGNPGNEQFYADFGQIVLTKISRIMQVSEENSLFCAVSHLNHVPMPREYSGMSIYNCADRISLADQIQYKFNFCLQYLPKTAKLILIGHSIGSYLMLRMLPDLLEHEFNVIRCIALFPTIEHMAESPNGERLLPWLKKFCKWDGVVKVVFSWLTYLPDSVKERICTFLIRKRNECFSPCILQSVVEIVDINVIRNIIFMAMDELLTVSNLDETLLLYNDRCRFLYGTVDQWCPLRYALEMQERLGKNIVIIDDKKCEHAFVLNHGEVVAHEVAKWIAECNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VGL0</accession>
    <name>A0A3P7VGL0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS1819</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Regulates cilium formation and structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000931">
        <property type="protein sequence ID" value="VDO30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VGL0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002354">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="309"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO30893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="699" mass="75388" checksum="20D79B4F2C79D208" modified="2019-02-13" version="1">MLQATSCAGCPNQVQCASGEIKRLDADLSAIADRLKNVKHKILILSGKGGVGKSAVAANLARALAKNDKIQVGLLDVDICGPSQARMMGVEQESVHESGDGWCPIVVKDNLIMMSIAFLLQNKSEAVIWRGARKNALIKQFLKAGFFDVDWGSLDYLLIDTPPGTSDEHISIVQFLLQAGSVEGAIVITTPQEISLLDVRKEIDFCRRTKINVLGVIENMSSFICPCCSKLSQLFPRTTGGAETMCSELSVPLLVSLPFDGRMAECADAGEDYFENYHDSPLAIEFEKLAQLISKTSASFPSKIVHDSMKRVVITGIGIVSPFGVGRRLLFDNLLANNVALQHDEKLQIIVGRVSECGENGLDLTSWAPRELKRMSRGSVLAVVAAEEAVKDAGLKECHMEETGVNVGMGIADLELIYHVGKQIAEGKGRRVTPFFIPRILTNMPAGHVSIKFGMRGPQLSSCTACATGLHSVGDSATFIRMGRAKRMLAGATEACVNSIAVIGFSQMRALTMTCSRPFDKRRDGFVLSEGAAILVLEEMEEALKRKANIYAEVLGYGVAGDAYHLTMPSEDGIGAFLSMGRCLTDSSINPKQVTYVNAHATSTVLGDRFESLAIARLFPGHIGHTLAAAGAIEAAITAMCVKESKLVGNVKLEESDIKENLRFLKQSERWNNERVALVNSFGFGGSHATLCLSAIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VJN2</accession>
    <name>A0A3P7VJN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006794">
        <property type="protein sequence ID" value="VDO48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HHA4"/>
    <dbReference type="OrthoDB" id="6344802at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="91" mass="10413" checksum="74D7276847D7EC04" modified="2026-01-28" version="1">MKCSCLGRKEISAGGTVRYCKSSAKSTADEFENPRIPPTRKQKFVSIKNWKGIKRDVTNAGIEMFLKMLSEHLEFYESYKFRNTANAAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XIN8</accession>
    <name>A0A3P7XIN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010781">
        <property type="protein sequence ID" value="VDO58624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XIN8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="88" mass="10732" checksum="C3287C46F26E86CB" modified="2019-02-13" version="1">MQYDDYWYDRYYYYSPLYRSTFYPRRYYYDGYALNPYKTLTRLTTVDIIIIMTIIHAFVTRISILIATAIIHHLIATRFRRLIGIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YY75</accession>
    <name>A0A3P7YY75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018541">
        <property type="protein sequence ID" value="VDO82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YY75"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="121" mass="13256" checksum="10E14F9D5B89B732" modified="2019-02-13" version="1">MNSSFDHGNGKETLISLISGRKQSSSTNISEINSPQIGRNSTNFLPQSQSTPIFHPRTIPPLFESPESNQSFSLSLSLSSSSSSAKENEENWNESSNVSNTKEFICVTCEGNCCCNKKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ALJ0</accession>
    <name>A0A3P8ALJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039852">
        <property type="protein sequence ID" value="VDP11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYC1"/>
    <dbReference type="OrthoDB" id="5850392at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="242" mass="28377" checksum="AF3C081437A985AC" modified="2026-01-28" version="1">MWSFLLIAFYVQQIDSIGIELLPRDCDCRDWSGGCRKDGEKWIEDDTWLYSCDGKEGEQSEFLGCQGGDRSGKLLIQAGENKTVDDFWFSCSHNMFRLKYEEESRCVVNNTQYHVGELFREGYFQWLCLESGRWITGCYYQNETKDWILLKIGQIGYNGLVKHVCDRYDDHPGRVQYYAEVRTDVPVKHPSNKGKNQNLPDLIDNRLKEKPIRWLHANAANFIENNGTFKSKIRYLRDSKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AM61</accession>
    <name>A0A3P8AM61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012042">
        <property type="protein sequence ID" value="VDO62095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AM61"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="107" mass="12613" checksum="4BDC772A4BC404BB" modified="2019-02-13" version="1">MDCFRSRGGAFKKINRESNIYLSPRNAINSEQEQRKEKGRSLLNLNDLDRLHNPIYFRKERENRGGAGHKRLNHFIQQIPASPLTPYYSSNMNWRSRSETSLCCERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AYT7</accession>
    <name>A0A3P8AYT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014216">
        <property type="protein sequence ID" value="VDO69528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AYT7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO69528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="161" mass="17828" checksum="79E83E8ED588D44F" modified="2019-02-13" version="1">MQALDLQIPLLVKAISRLLNTKTLKTKQYCFILLTHLLRAYPGALGDEIFHLTAGVSSAMNDRSLNTNVKIDTLTFLSGALCTHSPEKLHAYMDVLVPLIVRAVSEQFYKVAAEALTVTTSLIRVLRPVTSEQGNFDYSPYVDSIYEAIIGKLKATDIDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EJY3</accession>
    <name>A0A3P8EJY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039938">
        <property type="protein sequence ID" value="VDP12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZ90"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="211" mass="23895" checksum="9772F759957A8D45" modified="2026-01-28" version="1">MSWLGELLEQNSSDPRERLELGQQLLSQLQISKLSSDSKLLNDFCDLVVQWLSGSNYKVALLAVEIIDVAIEVSADVILPYLLDRATALVERLGDSKQSVREAMVQLLAALANTPHCSPQAVLERISFGLNHRQWLVRIGTMHVIRVVLEQQRRFVEPQIHRMIPTICHLIVDPNIDVREVAASTLIVIFWHLGENILTSIQKRQLIPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EXK7</accession>
    <name>A0A3P8EXK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040276">
        <property type="protein sequence ID" value="VDP14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="98" mass="10732" checksum="AA1FCBB1A0B9E4BE" modified="2026-01-28" version="1">MWCPSSRSTTSATIPKRRPFLFFVVVIVAAVAAAAQATLNKSHCPSVCPSRHNDVTTLTLLCLATGTQRTCPLPSHPSIHPADHPQSNIVLRYQWLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYW7</accession>
    <name>A0A183GYW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS427</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000138">
        <property type="protein sequence ID" value="VDO25757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYW7"/>
    <dbReference type="STRING" id="387005.A0A183GYW7"/>
    <dbReference type="WBParaSite" id="OFLC_0000042601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000042601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000042601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO25757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000042601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14497" checksum="1E36EEF4FB8E9BB3" modified="2016-09-07" version="1">VGNYGIGGHYDPHFDFARKEEVNAFQSLNTGNRLATLLFYMTQPESGGATVFTEVKTAVMPSKNDALFWYNLLRSGDGDLRTRHAACPVLTGTKWVSNKWIHERGQEFRRPCGLRRSVEERFIGDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ05</accession>
    <name>A0A183GZ05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS465</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000153">
        <property type="protein sequence ID" value="VDO25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ05"/>
    <dbReference type="WBParaSite" id="OFLC_0000046401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000046401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000046401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000046401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14651" checksum="0AE5C92CC17A3FDE" modified="2016-09-07" version="1">MTPTTELSDPSPTTLLFMPIRDSKMSAAIEKERARELGVEHSRTSSSCIHSRTTRRKDGVQSHSLDCGAFVVTDNYCGDSDSLFLSATYICTEVAYMYCFHVVRVNFKDAISEIHVAYVAMRSQRCMHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZM9</accession>
    <name>A0A183GZM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS689</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000252">
        <property type="protein sequence ID" value="VDO26713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZM9"/>
    <dbReference type="STRING" id="387005.A0A183GZM9"/>
    <dbReference type="WBParaSite" id="OFLC_0000068801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000068801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000068801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="3">
        <location>
            <begin position="312"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO26713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000068801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61368" checksum="7DB0E30EFA5F1C52" modified="2016-09-07" version="1">MSDNILLLEWPELKRVIAENRCELSLTSIPTGKRNPDINDEQLQSKIFAPNTPLNYIELTRLELKMLHTSVGKASKLKKLVLHSNALVHIPEDIGDLKELQFLDLSTNKLDHLPTTIGFLPHLSILILAHNKISFLPDMSGLVSLQHLDVSHNQLAEFPTSFPNHSKLHTLILNSNHIKELPIEVDTLNDNLKTVNLSDNEIVDLPFLFCNCKKIKTLELANNKFSDNRFKKLVEDPRHKTLAVIGYMKKKVPKIPRKNNDEEESKPNSINNNIDRDKYISNIPVITINYGVSNKILIAQVLIDRTKEASEIRPYIVCCVLKNCSLNAEKMKQLLNIQNKLHSSICGERTIGSIGTHNFGKLQSPLIYGAVDPDVLMITPLHRHKKISGRELLSNLANEAELIRKKEKRNVVSNIHRYMYLIQKLPLYPCLMDANGLIISIPPVTNCEETKLDVDTKDILVEVTSTVTEGTCLSIMDKFIEEIVMQGCLTNLTIEQIKIRQHNGELLVAYPSKNDLQISNCTIRRELIVEESNTCEIPKIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H127</accession>
    <name>A0A183H127_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glycerol-3-phosphate acyltransferase 3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS1187</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000523">
        <property type="protein sequence ID" value="VDO28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H127"/>
    <dbReference type="STRING" id="387005.A0A183H127"/>
    <dbReference type="WBParaSite" id="OFLC_0000118601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000118601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000118601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="252"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000118601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58749" checksum="43620B9911CC8D95" modified="2016-09-07" version="1">MVPTVLVLSFFDQSVGFNRYYVSCLLKIFEWSARQIRLSAKEKSQNSLNLCTKVDESSCTDDSDLELKHLTLFGDDFTGEKVIKGRKRRHSGPRIIFRETSMHFDDENGQQIANIRGWAVVRDSMHLVKAGIEAVIQDDVTSRFEAEQLVSWNMLTRTSLSFNQFINWKLSIIWALGFLFRYTVLLPLRLVLLFTGVGFMIVSTAVIGLLPEGSQKRWFNEHCLLCGYQILSSCVSAVITFNNRENRARNGGICVANHTSPIDVMILSTDCAYDLVGQRHGGFLGIMQLALGRASSHIWFERSEARDRSFVAEKLKEHVDNKNLLPILIFPEGTCINNTSVMMFKKGSFEVGTTIYPIAMKYDSRFGDPFWNSSQHGWFENCFRMLTSWAIICDVWYLEPMKKFPNENAIDFSNRVKKEIAMRGGLVDLQWDGELKRSRVPTKLIVHQQQKYFRRLARYFSEDMKKYVSAPEMRTIGCVCATNDQANENSESPLDVGMVFSDNLKYKDVSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1B6</accession>
    <name>A0A183H1B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000576">
        <property type="protein sequence ID" value="VDO28940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1B6"/>
    <dbReference type="STRING" id="387005.A0A183H1B6"/>
    <dbReference type="WBParaSite" id="OFLC_0000127501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000127501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000127501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000127501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62079" checksum="BEDC708CE8F2D60B" modified="2016-09-07" version="1">MDVVTAAQQYISEMIRLAGPGMKVMMMDKFTTSIVSCVYTQSDMMQKEVYLFERIDSVALRFITEDFREPIKHLKCITFLRPTDENVHLLTEELRFPKYGQYYIYFCNIISKTNVKTLAEADDQETVREMHEFFMDGVPLCSHLLSLNILHSYNSSFSVLTPVFTRSLNSIIATLLALKKKPQIRYQKSNKDSKILAEEVAKAIAREESLFENAKTDTVLLIIDRSEDPVTPLLNQWTYEAMVHELVGINNHRVNINTVSNTGALILSPLHDPFYSQNMYANFGEIGQNIKELITEFQRKSQTNQKLESVADMKNFVEQYPQFKKISGTVAKHLTVLGELSKLVSTRNLLEISEIEQQLVCGGEHSHCLATVRRLLQHEQTTDLDATRLVMLYALRFEHHANSDISGLIQLLRRKGVSSQNIKVVRAVLDFGGSVRRQNDLFGGTAIAMTKRFIKGLKGVENIYTQHEPYITELIDSLTKGRLSDTIYPYILTPLPNRTDNIILFIIGGATYEESRAVYMGNQRGRTLPGPPNTILLSTAMLNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1F7</accession>
    <name>A0A183H1F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1317</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000598">
        <property type="protein sequence ID" value="VDO29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1F7"/>
    <dbReference type="STRING" id="387005.A0A183H1F7"/>
    <dbReference type="WBParaSite" id="OFLC_0000131601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000131601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000131601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000131601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33514" checksum="62908E496D546056" modified="2016-09-07" version="1">MFAPDGSLIKKKNDTKKDAKRIETNQIDDQNESRRDDENLRDIGAADIRAADGPLINGDYDSYPDEKNIRIHEESKVEANFLRRNMHDIKNNGKLQSIDDDDNNVQQKIISSSTSKLFPSNNVERAITTTGAIKPILKSSTATRLQILISDENDTSANKYENFYLASKTEDGKPHRIFPRSNQSPVQVNPSREQIFEDGNIVQLSAWQKTKNRSLHRTTIHPNHFIVRDGEIDRNEVAPLIKSKSASHANFLPKKKSEFALQQHESAEDLINLARKSQPMKLIFDGHHEKVYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1N5</accession>
    <name>A0A183H1N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1395</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000647">
        <property type="protein sequence ID" value="VDO29373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1N5"/>
    <dbReference type="STRING" id="387005.A0A183H1N5"/>
    <dbReference type="WBParaSite" id="OFLC_0000139401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000139401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000139401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000139401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8862" checksum="0DF3F20DCDF1E221" modified="2016-09-07" version="1">MLRNINQSKSCNGTRLAVKKLVSNVVEVTILTGLYKGEDVLIPRIPMIPTDMPFQFKRLRFPIRLAFAFTINKAQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H263</accession>
    <name>A0A183H263_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000770">
        <property type="protein sequence ID" value="VDO30035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H263"/>
    <dbReference type="WBParaSite" id="OFLC_0000157201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000157201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000157201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000157201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19610" checksum="D180F42A3DEBFA91" modified="2016-09-07" version="1">MSNVDLQERLSRHRGFTTKAREVLLEPPAPFAVVAESSGSLSNESTNPKAPHRGFTAKAREMLVERQNSHHGSKCKFPDYIILLRLDFFFEQMRNLIYAFLTIRTDFDIFRKRQSQLNYLALDELPIQQANIGMNIFPVLYFNSNKDSDYSIYFYHLENCWLLKTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2U4</accession>
    <name>A0A183H2U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1804</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000920">
        <property type="protein sequence ID" value="VDO30842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2U4"/>
    <dbReference type="STRING" id="387005.A0A183H2U4"/>
    <dbReference type="WBParaSite" id="OFLC_0000180301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000180301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000180301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO30842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000180301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16715" checksum="A9F0FC4C44E8F68B" modified="2016-09-07" version="1">MVGMIVPSYFRENPIDTGIAVVNQVLTVLLTLPMFVGAFVACVLDNTVSGATREQRGLRSRGLAYELGENNYDVYAFPAFAMKLVEQVSYLKVLPFIPKEKKITNRVNDSLPCFHGYLLKESENEVDNCKPSNVPWLDRLVWSLPTDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3H4</accession>
    <name>A0A183H3H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001094">
        <property type="protein sequence ID" value="VDO31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3H4"/>
    <dbReference type="STRING" id="387005.A0A183H3H4"/>
    <dbReference type="WBParaSite" id="OFLC_0000203301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000203301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000203301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000203301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17929" checksum="CA48B6ABD0B94C10" modified="2016-09-07" version="1">MDTPPYLSSLPEVLYHKLTPNDHFMVLATDGLWDCLDPDTVVRLVFDHTLGMQTLTPYTPFAGTTLAQVHEDLKQRLHKTRKKPLDENSATHLLRHALGGPGEVSAQYLRLIEMLQLPPDVTRRYRDDITIIVIHFDQNYLHNPKLPESLKIQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4F3</accession>
    <name>A0A183H4F3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS2363</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001345">
        <property type="protein sequence ID" value="VDO32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4F3"/>
    <dbReference type="STRING" id="387005.A0A183H4F3"/>
    <dbReference type="WBParaSite" id="OFLC_0000236201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000236201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000236201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="431"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000236201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61274" checksum="AB01CF2637081441" modified="2016-09-07" version="1">MDAISHSGQYATISEDIEVKNCDAESGRIPSPLSSVSNPKKKSSVEVDFDMQAKKSLSLRNRKLSLAGFSIGSEGSVETIQMQTNAQIYTKTANYKGTIVAVKNLNIDPKKYPKLDLTRSMLMEFKRIKDLQHDHITRFTGACVDCPHYCLVQEYCPKGSLEDILENEKIELDKMMKYSLLHDLVKGMYFLHNTFVGSHGKLKSSNCVVDSRFVLKVTDFGFHELHAMEDENSEEIGEHAFYKKKLWTAPEILRNPNAYPPNGTKAGDAYSFAIILHEMLFRKGVFYISDEPAPKEIYESVKKVPAVDEELCRPEVPENALIDGQSEPKLINLMISCWAEEFQERPDFAVIRKVVRSLNKSNETSNVVDNLLKRMEQYANNLEGLVEERTQEYLAEKQKVEDLLHQLLPRSVANQLISGRAVQAEAFESVTIYFSDIVGFTALSSMSTPMQVVTLLNDLYMAFDGVVDNFKVYKVETIGDAYMVVSGLPERHNHHASQIAQMSLALLHKVKNFVIRHRPNEQLKLRIGIHSGSFPKCFRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Y6</accession>
    <name>A0A183H4Y6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS2546</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001484">
        <property type="protein sequence ID" value="VDO33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Y6"/>
    <dbReference type="STRING" id="387005.A0A183H4Y6"/>
    <dbReference type="WBParaSite" id="OFLC_0000254501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000254501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000254501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF47">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="770"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="347"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000254501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="811" mass="90666" checksum="CC965F643BDAB728" modified="2016-09-07" version="1">MRTGMILLDCKAKTFVEVCDQIVNAMIYEGITCKRRDIMQILAMKQAHPLSRRMTPLSLAGSVFDRRSDCNLVGANITDNAKLRIGINIDLLKREHSFQMCNLHTQPAITEVDEMENSALSGIKGIPNSILKQQSFPDLPTVPAVQERLCLNPPKQSTTAHFISDSLGKVRTHSSELHKGEDILRKLPEGTETAQIFVGVIPNLTKTHFVMLRLSEPTTMPEILDGEVPLRFVVVILGPSQPDVSYHEMGRSIATLMTNMEFNALAYEANVREELISGVDNFLDDSVVIPPGEIDSKRLLSGDEIRKALKKRQNPKVAEEENSLPPKIEQRNNANFERQFEKREKYRFFSGMISDFEKRFPYYGSDYRDALNFQCLTSVVFMFCASFAPAITFGGKYTNEKIGILETLMAQCICGILWGIFAVQPLMIMSATGPVLVFEVSLYAFCTNLSIDFLTVRLYAGLWVLLISIITVAIDGSRMLCYVTRFTEDIFASLISVIFIAESLRFLYQTFIHNPVANFEFYHHIRQECEVHAITGNGNNSDVITICGGEPNTALLTTFIMISTFALAYGLRQLRQSYYLGRTLRRALGDFGVLISIAAVAGIAHLLVPDPYLQRLEVPDHFGFTNIEARQHGLFVSAYLPLNQLWIVFVALVAALLVFILLFAETEITELLLSRKDRCLVKGSGLHWDLLLMGVCTLLCSIFGLPWMCAAAVQSLAHCSSLSVPKKTAPGERAGVDYVLEQRVTTIGVSLLMGLFAFGGSYLRLPLASLFGVFLYLGVTNLTGLQFVQRIILFFIPEKYFPDTPYTESVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5G3</accession>
    <name>A0A183H5G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001632">
        <property type="protein sequence ID" value="VDO33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5G3"/>
    <dbReference type="STRING" id="387005.A0A183H5G3"/>
    <dbReference type="WBParaSite" id="OFLC_0000272201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000272201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000272201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000272201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21472" checksum="92F83AFB5716E554" modified="2016-09-07" version="1">MPNLYGEEENFLEGREALASFRDKLWTNGKIYENVASEANNIQRPVQTALQPNDNHAKSFSLKAIATDFTGIINNGEVIPQNHTIVISSGAQLLASRRMEKNSTQCIALSAPSSGTADDSSRNSLIPSSADAEHPRSLCTAHINPTLYCGRNCQAMRYFPTPPDSTMKIHLFVRKKSSANLNTIKSPKKNVPKGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5J3</accession>
    <name>A0A183H5J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001658">
        <property type="protein sequence ID" value="VDO34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5J3"/>
    <dbReference type="WBParaSite" id="OFLC_0000275201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000275201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000275201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000275201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39981" checksum="DC054BC23CC6C913" modified="2016-09-07" version="1">MLLFMGNTSNIWTSSSFNCYRDLCAASSGDHGYCGTEDVNALLILLLEHSLDKGYLDANDKEQLVNSMLYFPRGNESEIITSDPFCLKIVAVCVLGRQNAAQVVHYILRSIDTESRNGIPEHSTFWLLECVSELLDSEDLKKSASYAVGILYDALKSDIKRQRVRYVLEAVHLLLIGGQSHDLSKAPKWEDALLTRSVLNFNHWDELHDLYINWLYDMQWDEEHLPAHVILPPTVSFLSKIMNGTAILPAERCHFVRIRPLLLDSTYAAYLNKFNGEIATVNITHVLKIETFIAVGLPIVDDCSLIDLVNLPLIYYDSLLLFYNQLRKYRCSTQELMRIAEFVSGMYKNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Y1</accession>
    <name>A0A183H5Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA_mis_repair domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2890</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001784">
        <property type="protein sequence ID" value="VDO34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Y1"/>
    <dbReference type="STRING" id="387005.A0A183H5Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0000289101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000289101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000289101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00782">
        <property type="entry name" value="MutL_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000079">
        <property type="entry name" value="DNA mismatch repair protein MLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000289101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47523" checksum="3A04019379009E58" modified="2016-09-07" version="1">MIRRLPEDVVNRIAAGEVIVRAANVIKELIENALDAGATEIVITAKNGGLDLLKVQDNGKGIAKNDLPIVCERFTTSKLKKYEDLESMSTFGFRGEALASISYVAKVTIISKTSDSLCAYVGRYTDSQLQGGIKPSAGLNGTTVTAEDLFYNSPSRRRALKYPADEMNRIADVVVRYAVHNPSVSFTLRRCGSGSDFRTAGTNDLCKTISSLLGGKFSKDLVLLSHSDSALHFTLSGCLVRPTASCTAESLQNRQNRQKIFYLFINGRSVECNALKQALDVVFAAQNTMSPFVMISLQIEPKRVDVNVHPTKSVVYFLEQDSIITSIQDYVENLILSSTGSCDVCPKFSLMVDNTDNSSKSVNSSSTKKKQLMMLVPESLGGPPPSSNTKSPKIYPHQLVRTDAKERRLEEFIGSQSQIVSSHCAKNDAASRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6K0</accession>
    <name>A0A183H6K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3112</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001982">
        <property type="protein sequence ID" value="VDO35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6K0"/>
    <dbReference type="WBParaSite" id="OFLC_0000311101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000311101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000311101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000311101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12317" checksum="C98CB4543731E5C6" modified="2016-09-07" version="1">ITSLIVLVKFQNRSLPSAEKTGNSQSPGTVCGSRCSQLLLDLNIMNDLDLRKVHNIPKRLDLKQFFASFRRSFNHWCLLYEIPALANNSSIEGWGFDSHYVTVHKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6K9</accession>
    <name>A0A183H6K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3121</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001991">
        <property type="protein sequence ID" value="VDO35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6K9"/>
    <dbReference type="WBParaSite" id="OFLC_0000312001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000312001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000312001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000312001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10700" checksum="733EFF461D494460" modified="2016-09-07" version="1">MNKDRGYGIPGIGIGKRKKEEEEEIESFNDKLWLHIDLKLLIIAHRIEQSDTHSIANDLLCSLAGENGMLMRRKVYGRKDLRNGGTKEEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6N6</accession>
    <name>A0A183H6N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BRCA1-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3149</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002018">
        <property type="protein sequence ID" value="VDO35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6N6"/>
    <dbReference type="STRING" id="387005.A0A183H6N6"/>
    <dbReference type="WBParaSite" id="OFLC_0000314701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000314701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000314701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="313"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="454"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000314701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="584" mass="65871" checksum="8B11AE67FFC7E2FD" modified="2016-09-07" version="1">MSKVTPIIIRLEIQTGAPFINFDSSSSNKAKNKTQSGKKLMAERKKHKDVAAQSKTGNNSALPTAMDKAAEPVEQVSMQAQCLGNRKYAEVIVQTFSKDQAASKKQKPLISDTQEEPSSVPTVASGSSLSSKSSEGPDTCSISFFSGNPFVEKTSGILHFYKKKERSTATARNDCSILCMLGVPSLLSCRELLKFIAPSSQYITAMKVIRDSTPNQYMVIINFRSHDAAVRFYDEYNGITYNAIEPEECSLVFVEKIESVREEAGGSLPAENMTELPTCAVCLERMDDSVLTILCNHTFHAECLEQWADTTCPVCRYSQTPELVANQKCSVCGKTTDLWICLVCGNIGCGRYVEGHAYRHFETTSHTFTLEIGGERVWDYAGDNYVHRLIQSSPDGKMVEYRRSGTNDNSENSGEKLESIQLEYTCLLTSQLEYQRIFYENKMNEQERLFSTLEKHNQAQVDNLEREVEKTRKEYEELKKTLASCTEQRRIIEKKNHNIQNKLNKALAELAEERAFNKLLRSDQEKWSAKLAEMEAKNTSLNEKYVAAVNDLNEQIHDLMMHLEAETKIQDAVEKNEVTEQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H747</accession>
    <name>A0A183H747_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3309</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002176">
        <property type="protein sequence ID" value="VDO36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H747"/>
    <dbReference type="STRING" id="387005.A0A183H747"/>
    <dbReference type="WBParaSite" id="OFLC_0000330801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000330801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000330801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000330801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45605" checksum="04CAF9F35C0BC998" modified="2016-09-07" version="1">MITYCDCSNPILNQQIIDQLIIQLKNSDVENYRDFLKLFPPIKQLIQMIPSSLPLLDIIVTKSLKFHKNKSNKAAFHYDELFNYLLWWIAYNERKSILQNETSKMKIAKIPFSENDLSSANCEDWEKYVRSILAAIKTESPGILEAARCIELRLANSLEALGCHGLINYSEGLIGLLDAVRLEVSDHYKKIKEISEQFNDLKTVKHQFDNVASTESVQESKDDGEPSFWFLISGALNDLSSLLRIVRRRLICDQTLIKMYKMIVKSAPSGYTILDTDPVAADVIATFQIAYHKLLSLVDHQYNTYLSNDNHTNQTNHEDEYQFLLSASDSDVETNFPIIDLSSKSQIAISSMFRKNNYSTLTTNNIIPRYHSLNDLCKSSCNQGNELRSARSMSSLDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H938</accession>
    <name>A0A183H938_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002879">
        <property type="protein sequence ID" value="VDO38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H938"/>
    <dbReference type="STRING" id="387005.A0A183H938"/>
    <dbReference type="WBParaSite" id="OFLC_0000399901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000399901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000399901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000399901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11095" checksum="3633FADBF59249D6" modified="2016-09-07" version="1">MDSFITEQQPNHDGYFRLSAGRTMLQKPILVISHQCGMTHNERQQDIYRQFIIYIPYFYYNSGRIGLKIFHIGRLGLDINYPNERNEPLADITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB82</accession>
    <name>A0A183HB82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAF250_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003763">
        <property type="protein sequence ID" value="VDO40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB82"/>
    <dbReference type="STRING" id="387005.A0A183HB82"/>
    <dbReference type="WBParaSite" id="OFLC_0000474301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000474301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000474301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000474301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="568" mass="62021" checksum="BC230C1671E41F2F" modified="2016-09-07" version="1">VDNQQGQGSQSRAPSTGPPLATTPDSNSRHSEESAPLRPPSHPQQIPNATTSCSIPPSIPAQQQPSVPYYGQPHTPQMYGAAGLRPGTGPPGTLSMKTGSYHQAYPQSQPGYPTHNYQEGYQAMHPGVATQMYQQQMWNSQQMQRYSGPHANIPTSSSMGNTQMGTTMVSRVSGTLPPEMQQHYAARRPPFCLQTPGPAIATTVPGTTTRLRYSVPPSNSATHQQLQPQYPSHSVMQGGRVIGASSSPFPHMGPSTSTGFTGIHGTTGSLGQLASGLNVPPSSMHTPSAASGPGTAVAAMMHPSFAQFSQPQPMQFPAGSVEATAISQRRRRKLVMKDLMRVNMKRITMALRSGLETETTWALNALNVMLYDDYAPPTILNHTPGLLNMLVEHFRALLSLLYPKVFEVGAESKARTTDDEYNEFGTESSKLEQTTAPSLVTSRSLKNEPTNFTKISRTGRTVHIEKKELPECLKRARPSGWSCDITDETLSLDYHESRMSSGLGGETSSYLAARLVTDIEFRKQLKKPRFFMKEVNGISKMVEADIDEVAYYSKIDKVSESVRYSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB87</accession>
    <name>A0A183HB87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4748</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003767">
        <property type="protein sequence ID" value="VDO40937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB87"/>
    <dbReference type="WBParaSite" id="OFLC_0000474801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000474801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000474801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000474801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37119" checksum="E451AC40195FEB21" modified="2016-09-07" version="1">MSNSTSFVIQDINECFSFRNELLKAISFVPFGFLSSACNIVLIIAILRSNHLRSRREIQIICALSIADFLEAFASFSAGIYRILVIVLDLKDKKFCLLHCMLLPHSWLWRWSDFATSFMLLTITSDRLISVIFPLKYINWQSTYSYIAIGIPYTLSILLSTFAWYRPLTKHAEISMLCTNVYISPKFYMFSKYLTAISSFLSVVFYIPAIFIIKTQRKHMSQILTNSQINRKRRAQMRMTITLAFSCSVTFFLDVIPRAIGIYGSFGENTVEMEKQCESAMQILFHLTKVNSIFNLFLHYHRNSAIRESILNVIRIFYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA7</accession>
    <name>A0A183HBA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4769</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003795">
        <property type="protein sequence ID" value="VDO40985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA7"/>
    <dbReference type="STRING" id="387005.A0A183HBA7"/>
    <dbReference type="WBParaSite" id="OFLC_0000476801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23203" checksum="F30C2968FBD33115" modified="2016-09-07" version="1">MFVFVKHKNQQRHSVDNSSVPENDVISMQQMEKNPAARKRINNSAYKPTSHITKKKIGYLGLAVFLGVLHGLMMTPIVYIQDTDPKASPNVLDYVFPHFCAVFFCSTIYFIGYSIWMRGRTHAPAELILPSAAYGVLWCIGMTLWFVSNRMLSQTVSFPITTRLPSTIGVLADVLLFKDVKGKKNLTVTFSAVAIGLIGVLLIAFSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC83</accession>
    <name>A0A183HC83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5096</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004204">
        <property type="protein sequence ID" value="VDO42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC83"/>
    <dbReference type="STRING" id="387005.A0A183HC83"/>
    <dbReference type="WBParaSite" id="OFLC_0000509401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000509401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000509401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF78">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="3">
        <location>
            <begin position="86"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000509401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40724" checksum="83B66CF82568CD56" modified="2016-09-07" version="1">MRRFDSASGPGARFIPGWVDKSQSKPKAYHGRLSDRTHSNQRERDRKRPAVNRPSIDRPNREPVKLHKAENAWKPERNIDANQKLYKNVRSLLNKLTPSTFDELSRDFLRFEVYKNKEQMGEVINIIFDKAVEEPNFCALYSDLCKMQVVKESKESKDKSKFRSALLTRCQNTFEEKRMSEINNKKTEMEKETDERKKRELKIELMEMEARERRRMLGNIGFIGQLFRHELIVPRILNWCIVHLLKNHSESPDGDEESIECAVKMLESVGKLADRQCQQQQHANFQSGSSDPHAQSAQQDHPQEAQKHEEFNTNLYFEHLKEVSTKVSNRVRFLILNLIELRNVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCD6</accession>
    <name>A0A183HCD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5147</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004277">
        <property type="protein sequence ID" value="VDO42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCD6"/>
    <dbReference type="STRING" id="387005.A0A183HCD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000514701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000514701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000514701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000514701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19276" checksum="6CEEC841349A303E" modified="2016-09-07" version="1">MQSGCGDSRCGEIHGTFMFRSQSVFGLACIRMFRLFGEMEAGGQEGGLPGASQGARPSNKRLQQTQAQVDEVVGIMKVSLYYSVCEGECENCLKKVNVEKVLERDQKLSQLDDRADALQSYHYLLQEGASQFEKSAATLKRKYWWKNIKMIIIMCAIVVILIIIIIVWAGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCP9</accession>
    <name>A0A183HCP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malate dehydrogenase (quinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5259</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004429">
        <property type="protein sequence ID" value="VDO42533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCP9"/>
    <dbReference type="STRING" id="387005.A0A183HCP9"/>
    <dbReference type="WBParaSite" id="OFLC_0000526001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000526001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000526001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000526001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14823" checksum="20CF150CE25582A4" modified="2016-09-07" version="1">FKQFQVELASRKEQIVPDTWGVEKSGHVCNDPAKILSGGGLLPLGGDELTGGYKGYGLGALVEIICGILADAKWGPYVRKWMTTTVIANLGQCFVAINPDGFAPNFEDRLQEFIDTMRGLKPVYFNIPQDFAGILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCT5</accession>
    <name>A0A183HCT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004480">
        <property type="protein sequence ID" value="VDO42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCT5"/>
    <dbReference type="STRING" id="387005.A0A183HCT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000529601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000529601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000529601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000529601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10246" checksum="99B6471D754097B2" modified="2016-09-07" version="1">MGNENNDQMPAVGSEVTLKGEQYHIESELYHGPFSKVYVISGSCMQYAMKTERTVGSKRSFLQYGFCISEYLMVDMMKNECGGHHEHLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD13</accession>
    <name>A0A183HD13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5374</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004580">
        <property type="protein sequence ID" value="VDO42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD13"/>
    <dbReference type="STRING" id="387005.A0A183HD13"/>
    <dbReference type="WBParaSite" id="OFLC_0000537401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000537401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000537401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000537401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15656" checksum="C660B361B3570F20" modified="2016-09-07" version="1">MITPSEIQKFTVCSESANQVQESAGDLFVPIDMPEPPKNSFLKEMSTLFVSQKESFDLDTIFLDKNPNSVPGSSMRSIAKTIPGPLSMEQASARAALHERGEKLNVAVEATERLKENAVTLSQRTGKLVEKYEKKKWYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HET6</accession>
    <name>A0A183HET6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005464">
        <property type="protein sequence ID" value="VDO45084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HET6"/>
    <dbReference type="WBParaSite" id="OFLC_0000599701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000599701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000599701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF6">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000599701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28766" checksum="967FAF45C93BE7EC" modified="2016-09-07" version="1">MQLVTIDGEADLTIHNISILPSDRCATDDQLASECCCGDGRFYDYPTKKCKVSQNVGFMFSRLNDSWSHMVVYGFVYPLIVFIMIAPLCAVLLGMGKREKREGDRRFPNPLYQMIWLLSFCGWISLLSPLPFSIWYYIIGDGIRSFNQSAVMCHMFQTTMEALPHTTDTMMTLFSILLAGGRFLTHYHRNTLKLRTVEHFSRAIWTVIFICTSMGILRFFEHGADVYQFCLGILNILLLLKLSIKVEIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF66</accession>
    <name>A0A183HF66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005660">
        <property type="protein sequence ID" value="VDO45525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF66"/>
    <dbReference type="STRING" id="387005.A0A183HF66"/>
    <dbReference type="WBParaSite" id="OFLC_0000612701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000612701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000612701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000612701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8535" checksum="D8E9F4358130CFB5" modified="2016-09-07" version="1">MFQLCNFGFLAKKISFQMKAISRLHFIDWLKPLQFVISAHPAIGKRTFAVICIDHQSTLHTDIRHRSGCESFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGK6</accession>
    <name>A0A183HGK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6619</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006401">
        <property type="protein sequence ID" value="VDO47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGK6"/>
    <dbReference type="STRING" id="387005.A0A183HGK6"/>
    <dbReference type="WBParaSite" id="OFLC_0000661701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000661701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000661701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052790">
        <property type="entry name" value="YEATS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827:SF3">
        <property type="entry name" value="AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827">
        <property type="entry name" value="AHD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000661701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34263" checksum="192811B069CDD51D" modified="2016-09-07" version="1">MVVFELHPDFSSPRRVVKEPPFEVSELGYGGFSIPIHITFTGASKIYKLTYDMNLVLEKYNEQFITQTIEMKQPSSTFRELILKYGGAKKDSDKRNRLRKGVTSSSEEPPPKREREKEKSRSGSNPPLSKLKIPRALVDSEKRQKNSRSASSENIANTSKSIVPAETKVTSNNETKTIAPSEVKQTEALSSEPSTSTESNCSDSEISKFTTFSAESTISMTPTTENDCTTEKQYDFEFLVRLQKKLMTLKDPDKMLAVVNTLLTPTSSNPNLPSGLLFTDNNLLSFDICKLNSSLIGKLGEICFGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGT8</accession>
    <name>A0A183HGT8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS6700</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01006527">
        <property type="protein sequence ID" value="VDO47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGT8"/>
    <dbReference type="WBParaSite" id="OFLC_0000669901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000669901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000669901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF40">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000669901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23903" checksum="4F582755EEEEC5BB" modified="2016-09-07" version="1">MSQGVSHFFFYFYTTSQIVMDILQYYETKVYYHTFTYRRMTQISRGIVTLLPWRSFPTGEDENPNKDVYRLAHSLANNDCLWRSQGARFVAFVDLDEYILTMNGVPLIAFIEKKAEQCPQCGSFAVIHRKMYYSSPRPRSEFHWDDIKFEWLINISYGLPEKDGPHKQIVQSKTVSIISTHSTRKSYPGYIDVNVGLFCTEIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGZ7</accession>
    <name>A0A183HGZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase epsilon catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006621">
        <property type="protein sequence ID" value="VDO47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGZ7"/>
    <dbReference type="STRING" id="387005.A0A183HGZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000675801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000675801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000675801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000675801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24255" checksum="7D93C602E5039812" modified="2016-09-07" version="1">MGSKEVKEYREYLNMNASQFSPTIIDAGNSTNLEFTSQGSVEKISNKKSGHESIHANSFMDVHSAMNKCADKRIVEEIMQPETSFIWADSETKKELLDETMKDNVTATVNSFMRTNLEGESVLRFYWLDAFEDPVKMPGTVYLFGRLINGGISESCCVIVKNIWRQVFFLPREKRLVNEVQTDEADLMQVNEEVQQILRSMGVKVVKCRVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI50</accession>
    <name>A0A183HI50_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="4">PNP</shortName>
            <ecNumber evidence="4">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7161</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01007290">
        <property type="protein sequence ID" value="VDO49619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI50"/>
    <dbReference type="STRING" id="387005.A0A183HI50"/>
    <dbReference type="WBParaSite" id="OFLC_0000716101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000716101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000716101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO49619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000716101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29589" checksum="2661E65893529236" modified="2016-09-07" version="1">MDFKIGIIGGTGLEDPNIFTDTQEFRVNTPFGLPSDALIEGKVGDNTCILLSRHGRKHDISPTNVNYRANLWALMQQGAKVILSTAACGSLKEELTPCSFVFLDSFIDKTFKREVTFHDGKEDHPVGVCHIPMHPAYNEKLRQVLITSAEELNYKFSKTGTAVCIEGPRYCSLAESEMFRSWNADIVNMTVCPEVYLAKELGIPFATTAIVTDYDCWREGEKVSVDLVAQRMRESSDRAKTLFVTAIKKIGAMDWGSEIMEAKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIC6</accession>
    <name>A0A183HIC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7235</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007413">
        <property type="protein sequence ID" value="VDO49939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIC6"/>
    <dbReference type="STRING" id="387005.A0A183HIC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000723701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000723701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000723701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05495">
        <property type="entry name" value="Bromo_cbp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010303">
        <property type="entry name" value="RING_CBP-p300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45926">
        <property type="entry name" value="OSJNBA0053K19.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06001">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO49939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000723701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30451" checksum="8EF08048F74A3970" modified="2016-09-07" version="1">MQPPQPGVDFDMPGPPNRTTPSFQPNTSVGTQQMNGLSTSLSGNAMTNGQLITSGIKMEVPSDVTTESSGAADASGCCSKPGTSNTVNAEKVKTSIGAVKTEMKAVKIDGKGETKVEERKELPDKVFDANELRNNLKPVVDKLLSMEESIPFRIPVDPDILGIPDYFDIVKKPMDLSTVSRKLDTGEYKNPWDFNDDMWLMFDNAWLYNRKNSKVYKYCNKLSEVFVEEINPVMQKMGYCCGQKLSFTPLALFCYGQSMCTIARDQTYHVYETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIU5</accession>
    <name>A0A183HIU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7406</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007719">
        <property type="protein sequence ID" value="VDO50843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIU5"/>
    <dbReference type="STRING" id="387005.A0A183HIU5"/>
    <dbReference type="WBParaSite" id="OFLC_0000740601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000740601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000740601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000740601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8816" checksum="4FF28BB2A00F7A92" modified="2016-09-07" version="1">MQSSQRLYPGLNTITSTATMTRYSPTGTGATTAAAAYRTRMPSVGIHKLIIIIMKISSSYSYLFFFLRSFIQNIFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJM6</accession>
    <name>A0A183HJM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyco_hydro_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7685</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008195">
        <property type="protein sequence ID" value="VDO52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJM6"/>
    <dbReference type="STRING" id="387005.A0A183HJM6"/>
    <dbReference type="WBParaSite" id="OFLC_0000768701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000768701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000768701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="2">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000768701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20390" checksum="AF39093CB57A5265" modified="2016-09-07" version="1">NRFKQSKFGFYKIIIFRFFKQTWNFDFFNYAGILRPVYITRKPFAYIDDISIKAGADGSFGYKVYTVSSTQLATVQVTVMDKNGTVIFENDQHHYTGRIENIRPWWPRNMGAPALYNFMVQLSISDVLIDVYRLWFGFRTISLSENQTFINGKPFYCHGFGMHEDFEVCFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKJ1</accession>
    <name>A0A183HKJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">UBP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS8002</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008731">
        <property type="protein sequence ID" value="VDO53583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKJ1"/>
    <dbReference type="STRING" id="387005.A0A183HKJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000800201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000800201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000800201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="15">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO53583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000800201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13426" checksum="2858581578D0946F" modified="2016-09-07" version="1">MHTVVPLPECPHLVEIRELPAEGVNASASCSECHSNEEQWVCLTCYSVNCGRYIAGHAMHHQMHTGHSMALSLTDLSVWCYPCESYVHNEILIPAKNAAHQSKFGIPIPEQGRSESENPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKM7</accession>
    <name>A0A183HKM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008809">
        <property type="protein sequence ID" value="VDO53758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKM7"/>
    <dbReference type="STRING" id="387005.A0A183HKM7"/>
    <dbReference type="WBParaSite" id="OFLC_0000803801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000803801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000803801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000803801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20611" checksum="226C4DDCDD3167C3" modified="2016-09-07" version="1">MIIKDNDQMDQLLTGQISEPLLQDFEENISNWIHTGNIRKLDDVVLNGYADLLSGRAHETDDPDVRHFLDELPQYRNKINAIHKAIEEDNLRTIQALIDRKKMAFCRDPQHLTPLHKAIILGQIEIAKYLIKNYPQTANAIDENKRTPLHYAAALSDDGYLYKMMRNAGADSKIRDRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKT9</accession>
    <name>A0A183HKT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8103</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008909">
        <property type="protein sequence ID" value="VDO54022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000810001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000810001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000810001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000810001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3729" checksum="4EB00645EF47CCD6" modified="2016-09-07" version="1">MSRYDCGDPPPYYSHRRSTHPEDGINFIICNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLI0</accession>
    <name>A0A183HLI0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS8337</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="UZAJ01009326">
        <property type="protein sequence ID" value="VDO55138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLI0"/>
    <dbReference type="STRING" id="387005.A0A183HLI0"/>
    <dbReference type="WBParaSite" id="OFLC_0000834101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000834101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000834101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO55138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000834101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21726" checksum="EFC2F280E1B8225C" modified="2016-09-07" version="1">MFVMLFQDRDVFVDLGSGVGQLVIHMAGGSKIRKAIGIEIASLPNRYAQNLSVEFKKWMKWYGKKFRPFELHKGDFLDEKFRDLITKEATIILINNFAFTAELETRIKRELLSELKDGTRIISTKPYGLPNRTITDRHLNDISAILDVFEMSQCENACSWTSNYVAYYHHVINRAKVNQQSQNLAFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLU5</accession>
    <name>A0A183HLU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger SWIM domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009576">
        <property type="protein sequence ID" value="VDO55745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLU5"/>
    <dbReference type="STRING" id="387005.A0A183HLU5"/>
    <dbReference type="WBParaSite" id="OFLC_0000845601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000845601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000845601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000845601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29502" checksum="64B5B0642D01116A" modified="2016-09-07" version="1">MSDDHLETVFLNKDFSNFKTIRYFEKLGVFFCRSFRRSTAFASTKDVFLHGPALYTVLVISFSNMSDPISIETVIALHSAKMVMMEAYYFSSSIIAQSMIEMCLKEGHEVPAAYLDSLTSEDLSIQINSLQGLNGTITRYVSKDFGGHILMVENHHQREFLHVYCDCSQSTNVLSTRASLISLDVIPPMHRQILMLLSHFEMTQMYTIQHNLKQRLASSQGLQDWLSFAPSRLSLPATTDHVPVIQDPCISSLHKPRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMM9</accession>
    <name>A0A183HMM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8741</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010122">
        <property type="protein sequence ID" value="VDO57156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMM9"/>
    <dbReference type="STRING" id="387005.A0A183HMM9"/>
    <dbReference type="WBParaSite" id="OFLC_0000874001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000874001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000874001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO57156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000874001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20368" checksum="0298BA4FB81A27F4" modified="2016-09-07" version="1">MSLFRYNPRDYFYTSPMERFIVNLLDNTFDDRSSRSLHSVAPYWLHQPELNECNIGSTLGEVINEKDKFAVQADVSHFHPKELSVSVRNRELVIEGHHKERTDRAGHGSIERHFVRKYVLPEEVQPDTIESHLSDKGVLTICANKRVNGTPASRNIPIRASPKEPEADQKSMTNGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMQ7</accession>
    <name>A0A183HMQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010195">
        <property type="protein sequence ID" value="VDO57318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000876801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000876801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000876801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000876801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3789" checksum="5037F43B0DA3545E" modified="2016-09-07" version="1">MVLMVNPFILFIIKVGIKDMMKKLSIAVHLVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN66</accession>
    <name>A0A183HN66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8929</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010500">
        <property type="protein sequence ID" value="VDO58064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN66"/>
    <dbReference type="STRING" id="387005.A0A183HN66"/>
    <dbReference type="WBParaSite" id="OFLC_0000892701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000892701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000892701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO58064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000892701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22201" checksum="72CD9595776F0E5E" modified="2016-09-07" version="1">MAYVVPMMTMSHVAITASSFLIVFATVERFCITASNHYVKFLQNNRCCIALIAVLIGVFTKGTLLFELKSVHVLNCIGTLNEYRLELTALVIHNEHYKLFRFWFRNIVTILFPFFTLIFLNARIVNELRKNFLAEKLNVESTRATNAKERKARIRAATRTLMFVACTYLLANLLNVIITIWEHTDDKSLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNP1</accession>
    <name>A0A183HNP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010834">
        <property type="protein sequence ID" value="VDO58733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNP1"/>
    <dbReference type="STRING" id="387005.A0A183HNP1"/>
    <dbReference type="WBParaSite" id="OFLC_0000910201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000910201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000910201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000910201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16272" checksum="96A7E0B2B26B086C" modified="2016-09-07" version="1">MFVYIRVRAWVGVCVGVYLCNFFMQHCVCLPQLLYPTAAAAAAATNPLMNTLNGLQNTTSLAGAGQVNTSQTQQQYIDYATLAAVAAAGGAAATAAQNPFSLHPAVSAAGTVGLEQYAYMPYGLIPANSYAAQLTAAQSQLAAVTQQQAALEHQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNR2</accession>
    <name>A0A183HNR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS9125</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010871">
        <property type="protein sequence ID" value="VDO58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNR2"/>
    <dbReference type="STRING" id="387005.A0A183HNR2"/>
    <dbReference type="WBParaSite" id="OFLC_0000912301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000912301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000912301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO58800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000912301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21970" checksum="FC55C0276334C57E" modified="2016-09-07" version="1">MEAEEANMHVWVPDDKVGFILCKIIDIGDECLILQRLHGTETFRASYDNIFPAGEDTSQDVDDNCSLIHLNDGCLLNNCRLRYNRKQFYTYVANILIAINPYEQISGLYDIDMIRKYKGQSLGSLPPHIFAIADKAYRDMMRNHQSQSIIISGESGAGKTESQKHIIRFLCESWGHLVGTIEQRILESKNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP42</accession>
    <name>A0A183HP42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ipi1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011161">
        <property type="protein sequence ID" value="VDO59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP42"/>
    <dbReference type="STRING" id="387005.A0A183HP42"/>
    <dbReference type="WBParaSite" id="OFLC_0000925301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000925301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000925301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000925301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16530" checksum="68DD6F112CECCE18" modified="2016-09-07" version="1">MAMHSFVFHVQILPLRKGIFLNDLLGPIFNLLEIEIERIIPFLPVTLNQLFMLLPCSPTDEMALSTLGTLIGIIDKISASGQNHLLRTFVIYYFQSPAVKSKSNSEDETVHSALCKYITSHVNSPFFEFLFALSTEIVRILHSCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPH2</accession>
    <name>A0A183HPH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9384</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011444">
        <property type="protein sequence ID" value="VDO60168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPH2"/>
    <dbReference type="STRING" id="387005.A0A183HPH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000938301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000938301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000938301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000938301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8316" checksum="FC594FA6AACE2C8F" modified="2016-09-07" version="1">MALALLNVNMCQFSGCGLYFANLHDLLQHIEETHIPVIEDEMRKKEENAKNSALDDDPLKTAALTAVFPISAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPJ4</accession>
    <name>A0A183HPJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9408</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011486">
        <property type="protein sequence ID" value="VDO60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPJ4"/>
    <dbReference type="STRING" id="387005.A0A183HPJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000940501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000940501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000940501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO60339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000940501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20828" checksum="36CA1F1D089E40DB" modified="2016-09-07" version="1">MRLFVTDGKHNATTDLFVYIDDINDNAPQFEKNLYEITIFEEEQNVPKTLFIVKAIDADKQDDSSKIVYRLEGQGVGEFFQVGQYSGEIEVTRPLDRDPPAGVSVWKFIVQAIDDNGHGLIGYADVQVNLRDINDNAPIFASNLFGTIDENRDPGGIYYYFIDLKFWQNPKNIRRKRQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPL6</accession>
    <name>A0A183HPL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9428</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011534">
        <property type="protein sequence ID" value="VDO60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPL6"/>
    <dbReference type="STRING" id="387005.A0A183HPL6"/>
    <dbReference type="WBParaSite" id="OFLC_0000942701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000942701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000942701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000942701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12916" checksum="6958096EF791191A" modified="2016-09-07" version="1">MSTIIESFNRAKLDKKEFLLLKAIAFMHSECAGLTPDSYRQLSCQRQLILDTLFNYMMTKHEKHGPVRFGHALSVLWSVYEATNSYVESLMNMDLKPLTTELLANKLPEFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPQ4</accession>
    <name>A0A183HPQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spindle pole body component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011622">
        <property type="protein sequence ID" value="VDO60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPQ4"/>
    <dbReference type="STRING" id="387005.A0A183HPQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000946501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000946501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000946501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000946501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13088" checksum="1377262B54D3DF6A" modified="2016-09-07" version="1">YTVAATSDGTKLSNAIKDKNNGEVAAVRVKARYQSVQILPMQAYSDLLTFIKQYYLSLCRILEPTLGVKAKEDLATVLVRVMHKLHMAKYFLCDLIMSEVDVLGIYLFIFFRFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPS5</accession>
    <name>A0A183HPS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9483</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011663">
        <property type="protein sequence ID" value="VDO60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPS5"/>
    <dbReference type="WBParaSite" id="OFLC_0000948601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000948601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000948601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000948601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15302" checksum="578B890712B838B6" modified="2016-09-07" version="1">MIEEVIRGGGGGKGGGGGEGGGGRTRTILTDHHHDDDEDDNDDNEDRRQGGGKRNVVGKSFLQNCRQFCMLQFALLYHPIRAEAVIAHTPYYYYHHYHRHHHSQLGALQMVPFIQPLFEIYPKLPHLLNHPIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ95</accession>
    <name>A0A183HQ95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9659</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012090">
        <property type="protein sequence ID" value="VDO62239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ95"/>
    <dbReference type="WBParaSite" id="OFLC_0000965601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000965601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000965601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000965601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11757" checksum="04209F0EFA57CEAE" modified="2016-09-07" version="1">MVAVQTNVIVNTDSPKLTAEDLRSPEVTANYWRRLDEQLDIQIERKARINFELSIRLAKLNIEIAEKEEDYLALKHYISVEESAEYLSESELNENKEFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQT3</accession>
    <name>A0A183HQT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aamy domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012533">
        <property type="protein sequence ID" value="VDO63877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQT3"/>
    <dbReference type="STRING" id="387005.A0A183HQT3"/>
    <dbReference type="WBParaSite" id="OFLC_0000984401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000984401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000984401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF230">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="1">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000984401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20561" checksum="9FA9CF6E8F641E17" modified="2016-09-07" version="1">MVLVIWLNPFLLSDDFNDAIQDHLTVDSKLGTNDDAYELIDAIHDKEMKVVVNLPVSTTSKNHDWYRRSSQASLEENANFSDYYHWRKAEKDSPFMSRHKNISYMHYENRSDWPILNWQSGFVHQDMFNIISYWIDKDIDGFYLSGIEYLARIKSGTVAVRLCIFFQTPHLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSK2</accession>
    <name>A0A183HSK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10466</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013974">
        <property type="protein sequence ID" value="VDO68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSK2"/>
    <dbReference type="WBParaSite" id="OFLC_0001046301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001046301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001046301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001046301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4140" checksum="43A22566A2C45138" modified="2016-09-07" version="1">MKGNCQQRGKICRHLHFLMVHITLITVREEFALCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSM1</accession>
    <name>A0A183HSM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10483</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014012">
        <property type="protein sequence ID" value="VDO68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSM1"/>
    <dbReference type="STRING" id="387005.A0A183HSM1"/>
    <dbReference type="WBParaSite" id="OFLC_0001048201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001048201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001048201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001048201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10030" checksum="A1D1CB0AB41E7306" modified="2016-09-07" version="1">MFSSVRDGFYQELRRHRRQSPSYLKISPELSTSTEYLIGFPANVSFENDCYNNYDQTIISNNRLSIKHSLSAMNGEKRKFSDSQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTH6</accession>
    <name>A0A183HTH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10787</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014800">
        <property type="protein sequence ID" value="VDO71329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTH6"/>
    <dbReference type="STRING" id="387005.A0A183HTH6"/>
    <dbReference type="WBParaSite" id="OFLC_0001078801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001078801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001078801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001078801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7642" checksum="D5464DE8AA7CB178" modified="2016-09-07" version="1">MSWIALLGSVIMLFIFFFSYSLTSPASPIIKVEPGMANTILHVLSSPITFAYIIFVVLVTLSFDLVVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTK6</accession>
    <name>A0A183HTK6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 4/Protein SIEL C-terminal Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10818</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014865">
        <property type="protein sequence ID" value="VDO71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTK6"/>
    <dbReference type="STRING" id="387005.A0A183HTK6"/>
    <dbReference type="WBParaSite" id="OFLC_0001081801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001081801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001081801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="3">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001081801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21780" checksum="8DA9CA47400BCAB9" modified="2016-09-07" version="1">MAEVLIGIERLFVATQTKKFISGSSLTALFQSHSVLLQKKFASLGSISIKWAQIVEPSETPSEPIRFVVGLPLGISINILLHNFSKNDISRFRIKTDYPDRSSTLFCPRESDFKEIAAQTYRLLCKVLVQADNLWSDSARVRFGCVLKSQQFMDVMPSSVNGFIRSSCIPVAESPFSNKQAAMEISIQPIQAKASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTV5</accession>
    <name>A0A183HTV5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10918</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015137">
        <property type="protein sequence ID" value="VDO72399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTV5"/>
    <dbReference type="STRING" id="387005.A0A183HTV5"/>
    <dbReference type="WBParaSite" id="OFLC_0001091701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001091701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001091701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO72399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001091701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18072" checksum="0EE6BC64943094D7" modified="2016-09-07" version="1">IEKLIFLLVQHNFALSISDLIYLRILQGGKNGKGPRFTEVFTLTFFGSCVVTLNTKLLGGNISFFQSLCVLGYCLLPPGLAAVICKFIEINPEQTVFLFALRLLVTAAGFIWAIYASMVFISDSQPPRRKMLALYPIFLFYFVVSWIIISHSKFASYNAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU57</accession>
    <name>A0A183HU57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11021</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015375">
        <property type="protein sequence ID" value="VDO73168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU57"/>
    <dbReference type="WBParaSite" id="OFLC_0001101901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001101901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001101901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001101901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="4156" checksum="EAF3F4932EB9F590" modified="2016-09-07" version="1">MNYRFVERIECYSVNRYLLLLIIHSYYYYSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVJ7</accession>
    <name>A0A183HVJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nodal modulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016684">
        <property type="protein sequence ID" value="VDO76974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVJ7"/>
    <dbReference type="STRING" id="387005.A0A183HVJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001150901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001150901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001150901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49478">
        <property type="entry name" value="Cna protein B-type domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552652" evidence="2">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="3">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO76974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001150901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16066" checksum="C6FC0ABCA182EC7E" modified="2016-09-07" version="1">MNYLDIVKWLVLILTSISTVKTEVYSCGGFVKSPDVPIDYSKIQVKLFTAEGNLKFETECSPTNGYYMIPVYNKGDYSIRIFAPDGWFFEPSSFDLKVDGKNDLCTKGEDINFVLNAFAVEGVLRSGDGNGPADVALILIAENGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWX4</accession>
    <name>A0A183HWX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11986</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018001">
        <property type="protein sequence ID" value="VDO80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWX4"/>
    <dbReference type="WBParaSite" id="OFLC_0001198601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001198601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001198601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF117">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001198601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16732" checksum="ED2108259447A3F9" modified="2016-09-07" version="1">MRKKILFYSSLKITTKEKNYFSATDIDDLLQEGRTNAQGYFELSGYTSEITTIDPFLKIYHDCDDGFKERLRYSNLTNLREIKYFKNLTTSFKFQPCQRKVAFEIPTSYVSNGRQVEKFFNIGTVNMEIKFPGETRDCIHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP1</accession>
    <name>A0A183HXP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12258</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018804">
        <property type="protein sequence ID" value="VDO83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP1"/>
    <dbReference type="STRING" id="387005.A0A183HXP1"/>
    <dbReference type="WBParaSite" id="OFLC_0001225401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001225401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001225401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001225401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12673" checksum="C310545E52E56BB9" modified="2016-09-07" version="1">MLRSSDLTRAESAALRHVENCFRELLTLWFCQCNLRLQQLTIESPADILNKIMLYEAVHPITGYIDMKRRLGPNRRCFVFMHEAMDREPLVVIYAAFMKKIARNLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY00</accession>
    <name>A0A183HY00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sarcoglycan complex subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS12362</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039830">
        <property type="protein sequence ID" value="VDP11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY00"/>
    <dbReference type="STRING" id="387005.A0A183HY00"/>
    <dbReference type="WBParaSite" id="OFLC_0001236301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001236301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001236301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039972">
        <property type="entry name" value="Sarcoglycan_gamma/delta/zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939:SF10">
        <property type="entry name" value="EG:4F1.1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939">
        <property type="entry name" value="SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001236301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35901" checksum="61FF9E13C7BF83C0" modified="2016-09-07" version="1">MNTDMTTRLPMYQRSDEPVWGRSSYDFHRSPPSLQGAIVPPYSTTVIHPPLKAPSESDIYRIGVYGWRKRCLYGFICALTIAIILNLALTIWIISVLEISTTGMGTMKIEDDSIRIMGEVQFDRPIHFSELSTADNEALTIDSYRGVFIKARNVSGHQTAMINMYRNGHMEAVCDRFEIYDNSRKLLFFAEPNEIGLKLENLRILDDGGSVFEGAIQTALIRPEPDSPLSLESPTRSLNLEAGQDIEITSAAGEIQLSSLLEITLNSKQGEVRLESNNILMPELPRSEGRGISQHQLCICKNGLLFMAVVGADCRADRAICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYY2</accession>
    <name>A0A183HYY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12694</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039907">
        <property type="protein sequence ID" value="VDP11936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYY2"/>
    <dbReference type="STRING" id="387005.A0A183HYY2"/>
    <dbReference type="WBParaSite" id="OFLC_0001269501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001269501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001269501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="251"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="6">
        <location>
            <begin position="397"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="560"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP11936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001269501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="893" mass="102327" checksum="9A0BD269A2B64AAB" modified="2016-09-07" version="1">MQMKNVMKDVADYVNLNELFLLKSDTYSTVMQHPPALPLHKPPSQWEMKLYQIAERCLSTVINEDQLAQCSGILNRNMSDNTSDLCSSPSRGSGESSRSSNQHKSRIDFTSIKEGDYAIPPDASQDIRATLISSTEPLEKCGYLIQMTDNRLKSLKRRYFVFKNGFLTLYRTQKNHLKGEEPLIRIAMSDIRSVTKLVNKMGYGLQITTASNEYCYAAESDRATDEWIAILTRSIRTATISEVSQRATGLNADINGYVIKAKCGSARRFFASIVDNKLLFFKNSDDRVPCSHMYLRGAHICDKIKTVADESSGSSDEQNENHIKEFDHTISIEIANVDPVYIVLRSAEEKDKWIYFLEKAANDATFNGTAFETLMQRMMTQNVNDEDSLWNDVLLTICEEKPKVTLTTILDETLKKKALELGRACFMFTSVLMRPTGVQYHIDLAQNILTTAMSSDLLKNELYANLIKLTSGSMSYGIQAWKLMALTTPLFTPRQYSLLWLLRRHIERWSGKRCDEGNFALYCLRAFNRCLKAHGRTERPSKLEAISILTRDPTSTNMPHSIPVLLPNNEYQIIDFDGSTLIGDCLSTLCVKCGLRPALLSGYALYVEDPLERNSYVLLKGKQKLCDCISHWERELMDNKCGRVTDDVARIKLSLRQRQYWSHLVFSETPMERTFLVHRMANEIVAGRVPLSSELAEELAAVYAQLKYGNMGKISDEQFREIITTYYPSKLLDVCCERLLRLNLETNWSQLRDTSTADCIRIILVVLRKWRFFGSFVTEARMKMRNDESLFIALNDQGVHLLTFRQLDLIRSIPYHRLVSFGGYHNDFMLTIERVLPPQAHPEETTRERLTFSMPTRNIDQLTCHLAEYIRCQKLIWKLSIRSSRSAHNFTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZG7</accession>
    <name>A0A183HZG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12879</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039962">
        <property type="protein sequence ID" value="VDP12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZG7"/>
    <dbReference type="WBParaSite" id="OFLC_0001288001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001288001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001288001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001288001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10631" checksum="C7DF49C48A83E333" modified="2016-09-07" version="1">MTITQTTDAPTPSSIDDGRETRGDSQSGGAIVDDIANKTCMCINGRNNTLKRWYQMYRKEMEAVVSWRNGSNVTMNRSNAYHVLYIYTDIGIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I075</accession>
    <name>A0A183I075_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13137</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040059">
        <property type="protein sequence ID" value="VDP12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I075"/>
    <dbReference type="STRING" id="387005.A0A183I075"/>
    <dbReference type="WBParaSite" id="OFLC_0001313801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001313801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001313801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF139">
        <property type="entry name" value="SEMAPHORIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001313801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40640" checksum="F08BB4C0F8B04F0F" modified="2016-09-07" version="1">SIQSVDGRSDTFFYATFATPEISFGGSAVCGFSLNSINQLFDHGYFLEQTSSNGNWITTPLKNVPEHRPGTCTSNSASVPDSSLHFAKSHLFMADAVSANRPLLILRNELLTHIAVDPMEDVNVIFVYSHSSQRLHKVAHWFEEADGYSKLLATYTLKNTGTVFAMTLLPGDFLYLSSEDNVAQYFLAHCSLHTTCAQCAVDPYCSWNTARELCYKRDQAHLSTVGWVSSNSKDVAECVGHIRRMMINAYTGDTLHLTCVSQSSWIFNTEPVSPSEKRQLTTEGGLVVFNVSGIDSGTYECSVDGEDIMIYEVTVDDAECTQPTNVAQFKSKYREWCQKLAKYKYSAEKWQLWYDRNVRIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1S2</accession>
    <name>A0A183I1S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZU5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13684</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040333">
        <property type="protein sequence ID" value="VDP14392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1S2"/>
    <dbReference type="STRING" id="387005.A0A183I1S2"/>
    <dbReference type="WBParaSite" id="OFLC_0001368501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001368501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001368501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="5">
        <location>
            <begin position="856"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001368501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="960" mass="104054" checksum="4FE8ED98E7E5373D" modified="2016-09-07" version="1">MDGFTPLAVALQQGHDRVVALLLENDTRGKVRLPALHIAAKKDDTKAATLLLQNEHNSDVTSKSGFTPLHIAAHYGNENVAQLLLEKGANVNYQARHNISPLHVATKWGRANMVSLLLAHGAVIDCRTRDLLTPLHCASRSGHDQVVDLLLEKGAPISAKTKNGLAPLHMAAQGDHVDSARILLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRNADPNARALNGFTPLHIACKKNRIKVVELLLKYHAAIEATTESGLSPLHVAAFMGAINIVIYLLQQGANADVATVRGETPLHLAARANQTDIVRVLVRNGAQVDAAARELQTPLHIASRLGNTDIVVLLLQANASPNAATRDLYTPLHIAAKEGQEEVAAILMDHGTDKTLLTKKGFTPLHLAAKYGNLPVAKLLLERGTPVDIEGKNQVTPLHVAAHYNNDKVALLLLENGASAYAAAKNGYTPLHIAAKKNQMDIASTLLHYKVSPCQISFCVLVGAQARNGLTPMHLCAQEDRVSVAEELVKENAAIDPKTKAGYTPLHVACHFGQINMVRFLIEHGAPVSATTRASYTPLHQAAQQGHNNVVRYLLEHGASPNVHTSTGQTPLSIAERLGYVSVVEALKTITETTVITETTTVTEERYKPQNPEAMNETMFSDSEDEVLNSSSITVLTKYAIKWKVGLAVVVIVLLDAAAIVVVVVVVVVVVERFFVDSAPNTLEEDASHLRALAHSPLRLSTSDDHDLSFFPNHTSSPYPSPGATLIYLSREDNQITANAHTHDFSESLTKGLHDSTGLHLIHATEPILSRSPEMEGTDGDLDALIRKAQHEPITTAMADPSLDLSLPDNVAITKTTVQPSFLISFMVDARGGAMRGCRHSGVRIIIPPRKAPQPTRITCRYLRKDKLAHPPPLSEGEALASRILEMAPHGVKFLGPVILEVPHFASLRGREREIVILRSDDGQHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I214</accession>
    <name>A0A183I214_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13776</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040388">
        <property type="protein sequence ID" value="VDP14634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I214"/>
    <dbReference type="WBParaSite" id="OFLC_0001377701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001377701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001377701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001377701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="13161" checksum="7DB41A8B701F0CC6" modified="2016-09-07" version="1">MIIRFRFFQIIGFEVEHPDEFDDIKNWTNNKWNIHLDLLMNLVQELNLNFTLSQKRFVSMFGLSHWWKQEVYLMNKNNLFSPVLTPSIQMKTIFLWTEIFGRYGITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I228</accession>
    <name>A0A183I228_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040394">
        <property type="protein sequence ID" value="VDP14655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I228"/>
    <dbReference type="STRING" id="387005.A0A183I228"/>
    <dbReference type="WBParaSite" id="OFLC_0001379101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001379101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001379101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001379101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="531" mass="58175" checksum="C4E1F39A470F3A06" modified="2016-09-07" version="1">MGVIEGDSSVDTEFPSSVNHSQNHTSADNNHHSKKHTAIFSVQDNKVLYEGMLRFAHSAPCSPKNVLSRPEFRSCGATFRVRQSAKDGRSRLQLCPSAPEYRSVSINKALSTDALRPITSYSRNGTKSLSTTPVRELLQGSGGLKLEDLRPDLIMLSDSNEPQHHQASGKEAKPHHSNRHQSPTHLARVEEPFVSEKMIVASSAKAYSYTRPEQQHTSSFKTSGMQQVIGIKNYGGDAKIVVENEVSQENGSFQQLPVMRKYGVDESVKLSASEIKRSFGECFQEDMLIQRKRTYTEAVADIGIQKEHKITKKTKKADKISPPRAEKVMEKKQEEVDVQLALGAAQISNRGAIGIEMPSQHQSNFVTNLNPQPQTSTATTAQLADNWHVAAMASSEFAAICQRLLGKPDMLSTSQPAQPENAPVTGAASQNMPSYNSLLSDVALVTAVSQLEATAHMQYQSKIQQISASVESLGHLSNYVNYIKTLAGVPVSQSQQHSSASVASADAEQQQHHQNHSPEELQPQAQPQFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I296</accession>
    <name>A0A183I296_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040436">
        <property type="protein sequence ID" value="VDP14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I296"/>
    <dbReference type="STRING" id="387005.A0A183I296"/>
    <dbReference type="WBParaSite" id="OFLC_0001385901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001385901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001385901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001385901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17529" checksum="74F7A8B0EC294383" modified="2016-09-07" version="1">MKISPIKTEYKYQKVSDERDDVYPTRGLYPRPEESRMHRLEQELEEMILSYNSCDTKNEMTISLVFTEKIVEEENTEKELQIEISDAQRKAVVDFMQLHILNTPCAKLLLPEKYRMDQLKYMQKDYSINENTIITIVEGLFKDVMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2J3</accession>
    <name>A0A183I2J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS13955</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040495">
        <property type="protein sequence ID" value="VDP15113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2J3"/>
    <dbReference type="STRING" id="387005.A0A183I2J3"/>
    <dbReference type="WBParaSite" id="OFLC_0001395601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001395601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001395601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="34"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP15113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001395601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50599" checksum="ED393CCA0773172E" modified="2016-09-07" version="1">MNCTIIGRLSSSLTVHQIIIAIVLIVLIFFVVIGNTFVILSVIIYKRMRTFTNKLLTSLATADFLVGLFVMPLSLLDLLLDHVWPFDMLLCQIWSTSDVLFCTASILNLCVISIDRYLAISDPLKYSRTRNRKTAALLLGSVWLISLIVCSPPWIFHSDDYYTTIDVNISEATSCLNIIVCGYPNGIMYRIYSSMASFFIPLLLMCSVYWKIFRIVSTREKLLWNSINMKSYDKSNTTIQTSASQIRDRNSYYSPNGMLYSEEESMSEKCATHDLMYNAISVDTPTHRMDTDDGKLARIAQQCHLKLQPRYLLAKAHDRYQTSGPGKFTSNSREKIVYMKERKALKTIAILFFAFSICWLPFFVIYLIEVLVSSSNTIMYTTKEIFLWLGYSNSILNPIIYTMYNHDFRRCFRDLLTLGFMRKRRTMSIRKLHQQSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2U5</accession>
    <name>A0A183I2U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLOC-1-related complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040567">
        <property type="protein sequence ID" value="VDP15384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2U5"/>
    <dbReference type="STRING" id="387005.A0A183I2U5"/>
    <dbReference type="WBParaSite" id="OFLC_0001406501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001406501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001406501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001406501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13964" checksum="72099202B4D0E645" modified="2016-09-07" version="1">MNNDNSNVSSSSSSNRDNVNKTNKSFRRRRTTSFGKLSQFLQTGSILGDAGSIQSALLDLSAIGKLMTKITESQRRGVESLTVWAHNASNAAIDDVMQQTRQLYEIFIDKELQFVRQYTHYVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Z7</accession>
    <name>A0A183I2Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor SYF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14109</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040604">
        <property type="protein sequence ID" value="VDP15529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Z7"/>
    <dbReference type="STRING" id="387005.A0A183I2Z7"/>
    <dbReference type="WBParaSite" id="OFLC_0001411701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001411701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001411701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001411701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14973" checksum="822988987389BC69" modified="2016-09-07" version="1">MSKHTDAKGLSSALLQMKFMQKTRIRLEEEAKKKSERKLQKRFLKNDEKKQSKETEKITESTVKSESRYDLLENLSFGRMSFKGFNPEVEKLMKYYEDLKSGKVPDEDGFDGGHDITDYELATSMYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I418</accession>
    <name>A0A183I418_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040892">
        <property type="protein sequence ID" value="VDP17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I418"/>
    <dbReference type="STRING" id="387005.A0A183I418"/>
    <dbReference type="WBParaSite" id="OFLC_0001448801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001448801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001448801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001448801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35869" checksum="77DF341F33F4E457" modified="2016-09-07" version="1">MNIFPIVTKVLNSVLYTSLHIVQHKLLLISRRWKNFSSNKEEIKSRPNSESIVANNIEIKWTLTNGGGRSGVFLSLDANLELLKKTGKIDVFGYGKVLFNSRPHMIESVNQYQFIYDALAEALLCDNEPFAMSKLGKRSSLYKVKKERQLMDAQVADEAKLLAMLTPTLRIGDCAGGHRLENRGKNRSVMVVPPDHARPYLQTLHGKSKDYTYINAVEVDGFKRKKEFIVTEWPKKSTVDSFWTLIFDHSAHTVISLTNRKRSRKYPPFLHNKGKHTYGPFVVEILSHHQYPSMSTRMIKIMKKLHQIKAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I431</accession>
    <name>A0A183I431_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transcription factor HNF-4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS14493</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040901">
        <property type="protein sequence ID" value="VDP17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I431"/>
    <dbReference type="STRING" id="387005.A0A183I431"/>
    <dbReference type="WBParaSite" id="OFLC_0001450101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001450101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001450101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="110"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDP17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001450101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43009" checksum="B8C23309A33DD75C" modified="2016-09-07" version="1">RKVPEGELCAVCSDLATGYHYGVASCNGCKTFFRRTIVSEHTFVCQYQGNCDVNKNIRCACRHCRFNKCVAVGMDAKAIQNDRDRIGPTKKMKMNNQNSKDDCAIHIRSAEERLIERLLAIEKLCMRLRQCVLPEISGLKEAVCEPSLVNEVNNLKIDPYTTVKELYIATLKDIQMWNKREMRVGLEWAKTFDLFNQLSLDDRIALIKNFGFTFNLLNRNYYAPDHGADKLVLPNGAYIRRQVQNEVKLPGCRSIYHRQMDEIMIPFRQLKITMPEFALFKASVFFNPDAINLSPIAKSQIYAERSKYLSALFYLITSKCGITMGAQKYGSLLMMASSVQNIIAQNEENMQVMDFFEENWKMDNFVKEVCLKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I567</accession>
    <name>A0A183I567_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14879</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041315">
        <property type="protein sequence ID" value="VDP19392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I567"/>
    <dbReference type="STRING" id="387005.A0A183I567"/>
    <dbReference type="WBParaSite" id="OFLC_0001489001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001489001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001489001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001489001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6777" checksum="4DD43B65C3C06871" modified="2016-09-07" version="1">MKRISCLFYRHHTCRLLWIKWNEKRLLRSAAVSSSTSVDVVKLHSNRCTGLTASSSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6X9</accession>
    <name>A0A183I6X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042242">
        <property type="protein sequence ID" value="VDP22157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6X9"/>
    <dbReference type="WBParaSite" id="OFLC_0001550201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001550201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001550201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001550201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13803" checksum="D85B42B80B9B2689" modified="2016-09-07" version="1">MVDSKHLYHLTTGFTTRTNTMSVSSERSSQSFLSLRQRLIANAPSDGLLELAQSSTTTPIISADQLITSMTDSGISRGTISTFNLQSSIRSTDAKRIFGAEILSSEDETLDMMVPHTSTKNRNSITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I794</accession>
    <name>A0A183I794_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component PIG-S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15606</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042448">
        <property type="protein sequence ID" value="VDP22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I794"/>
    <dbReference type="STRING" id="387005.A0A183I794"/>
    <dbReference type="WBParaSite" id="OFLC_0001561901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001561901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001561901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001561901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14363" checksum="B62281FC2FE73586" modified="2016-09-07" version="1">MWMKYCDFIIFFAYLLVASYGSVDLRILKGKDTYTEELLIKRLKSEHLLTQFQFVITSDAKSGLDYALFPRIISEIVTKHHIQEFHLSLTQGFWRSNEWGIQPQPSSPSGAQLYAWINGNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I875</accession>
    <name>A0A183I875_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15937</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043310">
        <property type="protein sequence ID" value="VDP25155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I875"/>
    <dbReference type="WBParaSite" id="OFLC_0001595001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001595001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001595001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001595001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7264" checksum="4973A128BF35BD4F" modified="2016-09-07" version="1">MRNLAEPIIAADRLQEFGASYVNQDDITYGVIPHSYWDRLSAAITTTAKEFLNKQQLKNLFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8I5</accession>
    <name>A0A183I8I5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alternative protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16046</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043764">
        <property type="protein sequence ID" value="VDP26450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8I5"/>
    <dbReference type="WBParaSite" id="OFLC_0001606001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001606001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001606001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP26450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001606001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="5057" checksum="D11F372F46838125" modified="2016-09-07" version="1">MMMMQPTMKRDFSGVPTMKRDFSGVVYLSRSDHFWVQLQCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TXX2</accession>
    <name>A0A3P7TXX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000246">
        <property type="protein sequence ID" value="VDO26661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="153" mass="17458" checksum="7493E716FEDA783F" modified="2026-01-28" version="1">MDRHIHSPNSIPSSYGIPMIDNDSNNSYQCTPTYSPLTKQVDQLAYEMPHNKYAKNPWSCAPEFLKVFGDVRAQIGQHACFDCILLGSPRPKVCWLFNNEKMKFDDVQIDDTADLCRLTIPIIQHYHYGIYTVLCENEVGRAISSANLIPIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UBG5</accession>
    <name>A0A3P7UBG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001108">
        <property type="protein sequence ID" value="VDO31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809439at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="200" mass="24492" checksum="6E28C9F6CE6AED02" modified="2026-01-28" version="1">MNFPVYRARSAVTLPRARSVERGDVATLTRVASVPNLDDIHVGNRYRPSTLFKYRRDHDLLDDYYHDRMFFDTPLHWQDYRFAARRYINTDPIPKSFGFEYPAFWSRYKWYTDWLNPTYWRRYRDPNYDRPLWNNWQPWHLDRNNVKRAIRMYKEGLIDFGALDRFWIVPSALARKGKDWTDVYLPAGRYGARRYFYSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V6Z0</accession>
    <name>A0A3P7V6Z0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Homeobox domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS1681</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000840">
        <property type="protein sequence ID" value="VDO30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V6Z0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000080">
        <property type="entry name" value="Zinc finger homeobox protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000064">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="294"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="460"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="799"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="462"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="801"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="716"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125448" checksum="C409540EC56BCD0C" modified="2019-02-13" version="1">MTHLAGQLPISTDSAATTSKATSEQSTTSVDDERNSRTGAAFQKMLETYGALLTSSTDFPGFDVVMQYNEGLEQPHYHLDTLQDEAISDLSRIECIKCNKIFSSIWVLKAHYEEVHENTMPTIEIEKFAKRLHEALDENEEKENDESDLSAEQQNISIPVTTSVGVSGSKKRTLGRDELPLSSSHGAELNIDHGCFFTHAAATSATNEDDKYKLETKKLKEDTRSSSAGATPRPSTSKDSSDLNSQLAMMSMLGFPFMPNPFMPLMPSDFFTNPLFSVTQNAGTTAQHVIPSASPAKRARTRITDDQLKILRQYFDINNSPSEQQIKEMSVKAQLPEKVIKHWFRNTLFKERQRDKDSPYNFNIPPQMSIDLDTYEKTGETKITTLKIETEEESKPQLLPTPENPVNMSGVGNSISAANIQTTQIHSTPTTCNNPFATFLHDDKNLSSILSSLPSSNSVTGRRANRTRFTDYQLRTLQQFFDKQAYPKDDDLEVLSKKLQLSPRVIVVWFQNARQKARKIYENQPTSSNDDRFMKTPGSNFQCKRCQLVFQRYYELIQHQQKFCYKDDCVAQQKDNKVVEENLSEDEKTSLENLRDASRLSSTPIVTTNQTATLGGALAQLIGAVSSGTSTDINQAEFLKLQAPIKPQDPSMKLKVRDKKKAIFYKRCPFCCLLFHSRDSLIVHIPNRHPEQANNTSINVDLLPDAEDVPMITALAGDDSLGDESKTNGSSKKSELSPLDLSCTTNGEGHEDSVSISPSFIHSDNDDNNSDNMDVSERYNSASPNATGIGCFRTQRSPASSKRYRTHLTPLQVHVMKSIFMNYKTPSMNECDLLGAEIGLHKRVVQVWFQNARAKERKSRSHSGEDELLRCASARCAMCGVSYDHLVTLHDHIFTNGHINRVKKLLQTDNIHAEGPIDLNAAPETTDKEDIQRTRMKAIRDRRTMKPPGVSTSNPGSNTMPHFPYNFLCSIRSGLAPIMYDPNLMGTPIPMLQIPESVMTQITTDMTSGRESSKFTQDGKTFQQLVAVLPLRDFQCAGSTDSEVGWACPQCTNVFQQEQLLKNHQRLICQGCDSVFKLVQTHYQCRACNTKFGAQTEFRVHCDTLEHQAAREVFLGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V9X8</accession>
    <name>A0A3P7V9X8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01005188">
        <property type="protein sequence ID" value="VDO44400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V9X8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO44400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="234" mass="26774" checksum="B2E46BEFEF90D747" modified="2019-02-13" version="1">MIKENPDIIALQETKCTAVPDELQDGYHSFLNASEKSGHGGVLLLTKKEPIKVTCGFDDKSKFGVDDNGKGRIIVAEYENYYLINAYVPNSGRGLVNLDKRKVWDDYYLNFIKKLDSNKPVIYVGDLNVAHQEIDLANPKSNHNKTAGFTDQERNDFTRLLDAGFVDVFRRLNPEKEGAYTFWSNMHNAREKNVGWRLDYFVVSERIMNKVKECEILHSIKGSDHCPLRLTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W4K1</accession>
    <name>A0A3P7W4K1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002773">
        <property type="protein sequence ID" value="VDO38163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W4K1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF136">
        <property type="entry name" value="PROTOCADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="43"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="294"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO38163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="400" mass="44677" checksum="153D35744BF6FFD5" modified="2019-02-13" version="1">MGGESSERKFHKISVIASEDGKESEVPLDIHIKDVNDNAPVFTQPIYTATIKEDIPFGHTILTGKLNYMQAEDKDQNENGRIKYSLDDNNFTINDQGEISARSRLDADQNRERFFIYRFNVTATDCGDPPLSSNAVVHIRTENSNDEAPIFIPNGTYHAFVAEDAQSGTPVVQIQAIDPDRDQVFYAFLLPNGEEASTTQLFEIDRDTGLIRLGTKVKSEDLLHEQSPYNLTVVARDDGSCCGGDASEIHMQTASVIIDIADVNNNKPEFRNCDTYSSIAKIEEGDYKTNAPVILKVVATDEDSPPNGEIVYSLYYSQSESRKPFIINSETGELRPSPFVRFDREERAQEEVTVKATDKGERPLIGFCQFTVQVLDVNDNAPQFDRAFYETSISRSVDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XPW7</accession>
    <name>A0A3P7XPW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016602">
        <property type="protein sequence ID" value="VDO76760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HVG3"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="120" mass="13352" checksum="C1D6B6F67616A769" modified="2026-01-28" version="1">MSYVCGDSVNLVNEKSDVEVVDIFVDTLRDMFPQENIPDPEGYVVTHWGRDRHIGMSYTYVRVGGSGDDYDTLAEDIDGKLFFAGEGTNRFFPQTMTGACVSGLREAGKIANSWLKRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XZC3</accession>
    <name>A0A3P7XZC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014542">
        <property type="protein sequence ID" value="VDO70579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XZC3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="82" mass="9608" checksum="FCE49FB232CEC7D3" modified="2019-02-13" version="1">MIYKLIIIKVYSPKFEIRLQVSDTTRFEETVRTEEKNRIIILSLSERISDTCEFRIDKVELAISPSRGSHRYAQFITSALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YCS1</accession>
    <name>A0A3P7YCS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003134">
        <property type="protein sequence ID" value="VDO39358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5779987at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF51">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="224" mass="25696" checksum="DEE4F4B94BF242D3" modified="2026-01-28" version="1">MNIIILCSIFALILSYLFTIISVLTSTIALLTPQWQIVTITEFHTEHQHGLWMDCILGKKHVQGTSERSLHCTYKFENAQKNDLQNDEDNEEQHKFHNWHKAVLCMLLLALLSALSLCCFLMCALYFRIAALVSCTLSLFATIFSTVGIVVFFINSHKVEIRFVQGITRTYEQRCGYSFYLALSSCVTFLAAFLCTLFCTVMVFLHERNRRQTPKTYPLINSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YIU3</accession>
    <name>A0A3P7YIU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015105">
        <property type="protein sequence ID" value="VDO72287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YIU3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="159" mass="18368" checksum="6DE57AC429C8AA0E" modified="2019-02-13" version="1">MLYTFILHIYEFAGSLFYAQLIGAPETSRAYDSLNCEVRLHLHDGRIALVDGYPQRLIGFWFLNEIIRVCFNDNKLQFFANDRSGLDDGMYSLVCGRIQLLEKHYNLANKPGLLTAFLKQKEGDGLWYEDKFADSSQTIIQHSTLYIEVRAGNRKSQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YRE7</accession>
    <name>A0A3P7YRE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015811">
        <property type="protein sequence ID" value="VDO74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YRE7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="138" mass="15189" checksum="860A62D414400CC5" modified="2019-02-13" version="1">MFQQEESSSEQPSKAKFIEARVSWNDLNGNIATLSIIIMALSLRCAKCGALSFLTCSVKQLSTSHCQKCSNGFSIRISPQFVHQNSNVIALLEPKGCVPLDCVLLSSKLSYTCLHCNKETTAEVSFGIFIFVRLILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZD16</accession>
    <name>A0A3P7ZD16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006653">
        <property type="protein sequence ID" value="VDO47902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863076at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="71" mass="8109" checksum="DFDED20D88F3367C" modified="2026-01-28" version="1">MSKLFGEPHHPHLFASFDRVQSAFSTITELHFQMLPSIAASNWNQTSKKPGDKAMLIEHKDLDYNMDTTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A8R7</accession>
    <name>A0A3P8A8R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011725">
        <property type="protein sequence ID" value="VDO61098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8A8R7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="161" mass="19203" checksum="990E73948913632F" modified="2019-02-13" version="1">MPDRSSLQAITANKRARNAELTYLELNSKTEFHFFEYDSIITFMDRHDYLEFLYHINGVFGLVAIEKQQPVGYVLALNNHILQCYADNPEISCDLIRELSDKLSEQIPITMFMRECNYWICKELLYQARKVNRIHRFHSRILPTRVKWQNVFLMNIGIHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A9G9</accession>
    <name>A0A3P8A9G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010538">
        <property type="protein sequence ID" value="VDO58145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HN91"/>
    <dbReference type="OrthoDB" id="514167at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="137" mass="16108" checksum="8CD0E2196D3CB4A9" modified="2026-01-28" version="1">MSHRKLLLLGYPTSVINYESPEQLQQLVLFLEDQHIRLYKIEGRNGLQSSDIEVWNKSYAKYLADLKCPFSCDKDSPQEIIDWLLIRAIDSCYQRTVEGKDLTAEKYVQRKAEKEKEQKANDPLSAIDREFHIIYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AVH4</accession>
    <name>A0A3P8AVH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040353">
        <property type="protein sequence ID" value="VDP14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AVH4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="105" mass="12556" checksum="D4ADC50FB09F467E" modified="2019-02-13" version="1">MYCIISGSICFIHAIPSTILRSKRQTHIYDESLKQYARPHPRTRIMTGTIGRYAPHEWPNWYTRTLSKWNGEFHLGPYHPNDVLYEKYQRLKNQILNSNKLLPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AZ33</accession>
    <name>A0A3P8AZ33_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041354">
        <property type="protein sequence ID" value="VDP19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AZ33"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="60225" checksum="AB91293475545B98" modified="2019-02-13" version="1">MVLRICSIRILDYFDFISEAFFTHPFITTSPSSGKHNDLNPIPQFMSSPSHRALGPAMTSPAVSGRTVASSKLGSPHPVISSRCNTFPTSNQTGVVSDSDDFTFLPSLHGTQIPLANSRSKTHSPLVSRRPFSAANPNIDSYSGNPVKQIKIFNAASSARAVPVPSQRLAYAKMEERRNGSSTQHNHVVNIRCSARSLSGGATATTEPKVPSIEYISLPTTQFIVKDSRTSQYDTTLLNRARQYTIDTVATTSAACSSLELTPSVTSTTTNRKLLEAVPEVDAANVVPATPETRNETATNDEKLEAKRNIMENTQSFMEEGDVGRPSSPQPSPIPPVDNLKYLSVSPPRSCASLTVRAIPRVTNEISTSSSLSEEEEDVDLSQPIHLPFASNLSSRSQLMESESADEGICTGTQIAQDTSNTNASATNNQDAIPSLNDIAPSLEQETLMGAEHVQVLAKLRFVLELVETLINVAEDRGNPVSLSMPPRKKKERSDAYRRAEQLVVYVRALHMLSSALLLAQKQVASETLHPSPAVQHVLNQLNDKYHQCLVGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BEN0</accession>
    <name>A0A3P8BEN0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041632">
        <property type="protein sequence ID" value="VDP20451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP20451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="334" mass="38052" checksum="E5C759B54C888D76" modified="2019-02-13" version="1">MNHPIKSEKKKKSFRLTKICRRCEYSREPCGXXXSFRLTKICRRCEYSREPCGLVLFHYIGDHVVAAQVSDNAPHGNAKRTNQPFLRTLPIILQEVKEQSIMNNNAVEIYDRLTEQSIYDQCASSSRVTPRRLRNKEQVRNVMKSFRQKLARNSLYIHPRPTSLYVTEQEASALGGRILHRAKPELSRNQVVEDSVFEGQEGMPDGQSPVMLKKARVDDDSESSYAPIDVTTVDTQSIKTRTPYGSDHSFARQGGKFHLLIGITGSVASIKLSELITELYKNSPEEKLVIRVVATDAARTFIDESTFEVPIYNDLDEWSMWKKRGDPVLHIGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EQ33</accession>
    <name>A0A3P8EQ33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039834">
        <property type="protein sequence ID" value="VDP11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="75" mass="8709" checksum="AB548510D4B3387A" modified="2026-01-28" version="1">MGEYKWGYPLTALNDTLNNGMVTESILYYQTKPIGFNATQQVQERFDRKASQYVCFCSSWCSRDLQDKWIGGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F9X7</accession>
    <name>A0A3P8F9X7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041232">
        <property type="protein sequence ID" value="VDP18933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8F9X7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP18933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="374" mass="43250" checksum="657B32D8C96383B4" modified="2019-02-13" version="1">MTSIFSAKNIRQVHWRKILIDSIRSSFFLTANLIIFLWLSCQLRKMLGFFTVPTLGLTNGIISALLAILIENRRRRPLLALYLTNLASETAYHQLVNHGYLKYIPNGVVIIFGFGLAGLLHLYYKDKLRTNLRKSIEYVSFVQWTLLISVLNVVVSQPVHGVLRDVCCNMATVKSQVFFNNFSQALIWSVGMVILQIGKEIIRQPSASIRRILRFRTMRLPLFYGFLALLFQVSRCGYSWCTNETSPLSFCGAIAAFSLFFYPNISIAMYVFWKFIEGFFFSYYKNLMIPYGDIILYALSTGYVAWNAVIEPQTLREGYWKFLVGLTGNKIELLNRRLFDNFGYNSSKKFPHFMPKLDPRFTSFNGIWSVIHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY31</accession>
    <name>A0A183GY31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS141</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000033">
        <property type="protein sequence ID" value="VDO24694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY31"/>
    <dbReference type="STRING" id="387005.A0A183GY31"/>
    <dbReference type="WBParaSite" id="OFLC_0000014001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000014001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000014001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="2">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="158"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO24694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000014001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34125" checksum="05D50DE85B0480B0" modified="2016-09-07" version="1">MDTPAASTSANNQHHPPFTSTGTVEVPVFYPTIQEMRDFPALINKIEQQHRAHLVCGIAKIVPPPEFYARKSGDYSDVDNYVIDQPVKEKIEGNAGVYTKTNKLYRRSITVREFRALAKKSPFPKGDLSPQEIERYYWKHILQGEPVYGADSPGSICDENLREFNMNRLGTLLDMLDESGIKIKGVNTVYLYFGMWKTTFPWHSEDMDLYSINYVHFGKPKFWYAIATDSLNRFERFAAQCFPSAAKTCKSFLRHKTFMISPQILRKNNIGYGTMIQYANEFIITFPRVNINCYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYA1</accession>
    <name>A0A183GYA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor ISY1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS211</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000058">
        <property type="protein sequence ID" value="VDO25011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYA1"/>
    <dbReference type="STRING" id="387005.A0A183GYA1"/>
    <dbReference type="WBParaSite" id="OFLC_0000021001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000021001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000021001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO25011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000021001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30386" checksum="DB786E3718F3F5E9" modified="2016-09-07" version="1">MACKLTIVPGLPCSYSIMARNAEKAMTALARWRRMKEEEEKGPVAKRPNDVNECNTLNDAERYRKQVTMEIAKKIALIQNPGLGEFKIRDLNDEINKLLRVKYAWETRIKELGGQDYRKIAPKELDREGREVAGSKGYKYFGAAKDLPGVRELFEKVGIDESRKNRMELIKFLDADYYGYMDDDDGLLVPLEMDAEIKARLQIEKDWDENKDALKAKKAFEEIDIYKIVDDSDEEDINTKQSILIGDDGKKTFIQHVVVPSQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ38</accession>
    <name>A0A183GZ38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SLC3A2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS498</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000168">
        <property type="protein sequence ID" value="VDO26000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ38"/>
    <dbReference type="STRING" id="387005.A0A183GZ38"/>
    <dbReference type="WBParaSite" id="OFLC_0000049701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000049701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000049701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024883">
        <property type="entry name" value="Neurensin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14796:SF3">
        <property type="entry name" value="NEURENSIN 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14796">
        <property type="entry name" value="NEURENSIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14927">
        <property type="entry name" value="Neurensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000049701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27739" checksum="9765AC6CDA931FA6" modified="2016-09-07" version="1">MTIFGRGSTPRKEETTDNGTSKPTALLDGVTTPATGFGIRSYLHQFYQSPAVEDIESAGAWYLLPPPPAQRTGLWLCRVLTVFGLILLIGGAVAIVIGYTWPHEGVEESIARIAIYQDEDGSFYVPPEKLTEILKDPMRRWKMFGLCMFASGAVMLALSLLTPTLVGSFKSKRLAAFMSEDSTPNEPPIRLYPAISGKNEVIRHPNNYPHEKQDKITPDSYVSYNFLMFFIQEKYYKIIRNLFFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZP2</accession>
    <name>A0A183GZP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Bms1-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS702</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000258">
        <property type="protein sequence ID" value="VDO26757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZP2"/>
    <dbReference type="STRING" id="387005.A0A183GZP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000070101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000070101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000070101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="119"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO26757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000070101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121315" checksum="BD266B1E6B7B4E7C" modified="2016-09-07" version="1">MRCLDAKLIISFICLPGGLGPIAVGLDIFNKSCFQLVSVRNKPMAANENIGKSDHKIHRVHKVGGKAKKKAVKKGNGVNAKAFTFQSAVKASRAIRRTADKDERKKHIPIVDRTPVEPPPVIVAIVGPSKVGKSTLLRCLVKHYVRHTLTEIHGPITVVTGKTRRVTFVEVNNDLNSMIDIAKVADLVLLMVDASYGFEMETFEFLNICQVHGMPRIMGVLSHLDIIKKKEKLKHTKKLLKHRFWTEVYQGAKLFYLSGMINEQYLKNEVRNLARFISVTKFRPLLWRTSHPYVYCDRYEDLTDPELLREKPLVNRTISLYGWVRGTFLKNHATVHIPGMGDLMIKDVMALPDPCPLPSKEKMKRSLNERERVVYAPFSGLGGIVYDKDAIYIETGGSHSYKKARHELVEVLENVKEGIDNKMHKTALKVVTDSQVVIAHSESESETVDDDCNMKNEAESSGEESNDFEDLDVVNGVSQVENEEKDIEKKRWCELCARAKLLYNEKKSKRLNWAKIVYSDSDLLVMNKDEQDEVLGGLFKVLTRTKKTIDDLEDGILYCKPSTMTSQQILKQRDWDDLEIRASVADCFVTGNWNPDEDATVQLEDADGGKVEHSDKVEEKIDPATAAARNEEEAAKRRKIFKEKLKSRFNAEYDETNKHYIQLKGELEEQSKLNKSVFEELDESVRQQLEGFRPGLYVRIEFEDVPVEFVQHFDPTRPCIIGGLLTGEQNIGSVQVIYSIQDHNMRQRFLKYTPEHMFCQAVFWGPITAQNTGFLAVQSLSRDMKGFRIAATGVVLNLDKAFQVVKKLKLIGHPYRIFKKSTFIKGMFNTVLEVAKFEGGIIRTVSGIRGQIKKALHEPAGAFRATFEDKILMSDIVFLRAWVSVPVPHFYTSVTNLLLQNNQEWEGMRTVGRLHFEMGLKPPMKMDSFYKPVERRPFDPAPLLVPKTLQKELPYRLKPKVAKEIEKKGDKLIKKHNVVILEPYESKINRFIEILDTVHAEKVKKERTTMEERVKKHHAEMTALEAQRKIGIKKTKKKICRTLSKREQMKLRKALDSVNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0M9</accession>
    <name>A0A183H0M9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BB_PF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1039</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000442">
        <property type="protein sequence ID" value="VDO27994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0M9"/>
    <dbReference type="STRING" id="387005.A0A183H0M9"/>
    <dbReference type="WBParaSite" id="OFLC_0000103801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000103801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000103801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000103801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25351" checksum="EAF443A359CFAF0C" modified="2016-09-07" version="1">METKSVSRQDFSPKKGERYAAKKPCDSDILFGDCSFRTETHSQTQEQQKQDGSIMEMKKKYCNAVDTENLKATPELIVYDIAEHNRAFAKNGATAYTETFYEGVPAEDVRRVILRENHELKLPENHLEDQSFQVSCEIPTASTTQIQMTSTKLQESMLWQNGQIKAESQYNTDFVPKLKSCPAGELIASIAKNHSSTEHFEFYRILGGHHFYEPKVDNVQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1J9</accession>
    <name>A0A183H1J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-catulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1359</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000622">
        <property type="protein sequence ID" value="VDO29234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1J9"/>
    <dbReference type="STRING" id="387005.A0A183H1J9"/>
    <dbReference type="WBParaSite" id="OFLC_0000135801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000135801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000135801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO29234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000135801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34016" checksum="126D018DF60ACE0E" modified="2016-09-07" version="1">MGSTLINGAVNPSYTFDPQSLEIKTKSVEQTLVPLVTQITTLVNFKESYLSGGKKRSEKALRSALKIGSAVEAAIERFVVVGETIADENPDIQPEMYDACHEARLAGASIANLNGCLTDDAIIDKAILVRAARQLLFSVTRVLLLADRVLVKHILRSEDKIAFSLVKLENTTNFTDFVKIFTEFGGDMVDLAHRSGDRQNDLKNEKRRGQMAVARTMLERLTMLLLTSNKTLLRHPDSDSARQCRNGVFQQMRLALQLIALCVSDGVMHFDATHFTSPSSDEVLDIGMQLTANAAIRRLMVFSLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Y8</accession>
    <name>A0A183H1Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">INTS5_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1498</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000717">
        <property type="protein sequence ID" value="VDO29769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Y8"/>
    <dbReference type="STRING" id="387005.A0A183H1Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0000149701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000149701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000149701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000149701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15419" checksum="D9EB544041BC922E" modified="2016-09-07" version="1">MIQFENSSDQKSLPRKQLINMLDKWFLLARKGQMLPKQMIYYFELIMRVSYREGFVILFDIWQYFQSVLDAEVSAANMINAAFDRSLNSPIDPIQGDPTKFRESCRLVIQRNIAKLGFIFPLIFADELNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2F9</accession>
    <name>A0A183H2F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase, eukaryota, reverse transcriptase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1669</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000833">
        <property type="protein sequence ID" value="VDO30385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2F9"/>
    <dbReference type="STRING" id="387005.A0A183H2F9"/>
    <dbReference type="WBParaSite" id="OFLC_0000166801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000166801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000166801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000166801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19699" checksum="1A2F3EC82B8DBBFA" modified="2016-09-07" version="1">MVALNDAERLHAQIGWYDSLTFMKKASKVWDIDWENAISNVSFVQNPFKPRNKTFTDLVAISMANFDTEENSKDCVCGDRWKLPDLSNLLYLSSSKEDKHGMCLRQPYHQILSSDSKIRQYKAFIDVGLEEFKGGGKVGEKHGNSTLIEMVNSALRRGKKKLENYDDRTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2M6</accession>
    <name>A0A183H2M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1736</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000874">
        <property type="protein sequence ID" value="VDO30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2M6"/>
    <dbReference type="STRING" id="387005.A0A183H2M6"/>
    <dbReference type="WBParaSite" id="OFLC_0000173501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000173501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000173501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO30604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000173501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="689" mass="77942" checksum="80510B40F2B29A7A" modified="2016-09-07" version="1">MWHQSGTYHLISALNLLDRHYNPSLLLAQLHSMTLRSKSLLLLAVVLPLHQYVEFHPTNRTNRPDIKISIKGKTFEEQAGSLVTDILEPAGFELLKWGKLPYLSEGDSRRVVRRENICTSFRVKVVVLAVVEIEITTGILYLHCCDMAQEVGDERMTDSDTESFHSAVGSLSDREEININDTNLMSEENDEGRKESSKCKTIPKERNHDCLSMDKAHFDSEMKKIKPKQEIEVDGVPSGKMLDSQILKWPTSKSSKMGIGKISRSENNHKSDKISRKDKKIFEINRLKDGRVQNCGIDSDKTFGNKNSEEEFKLEITDDVDNAIMTEEIERSEEKTDTDGWDDWELQYPRTDENNVGILDKNRELPPMLASDEENQISANSKLGSRLEKKEVRTNKSFWNWTEFGDVVAAVGEGLTNISSAVESSLGLPTPEELVKSQWTESPANASIKVAKAGFGVNVVTGSLDVLEALGKKTFEKLTVSEQGSEKRRFIFEPERGQNLSEVLRELRESRAEEVALETNCIANRELTFIDFFEKFSGILHLEGLEMLSKNHLRKIPPQRRRHGSDLVDSYRRCQERLKGLSDSNDQILALFLECLADFTAHSVQSIHKLGQLLLISATAVQQEPFSDFHSLIGRQISFFSNQFAQHISAIDTSSEEIEELVTAVFLAAGDSFSYVQQSFRLLRPLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H330</accession>
    <name>A0A183H330_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS1891</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="UZAJ01000990">
        <property type="protein sequence ID" value="VDO31146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H330"/>
    <dbReference type="STRING" id="387005.A0A183H330"/>
    <dbReference type="WBParaSite" id="OFLC_0000188901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000188901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000188901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000060">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF451">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="585"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Plasma membrane calcium transporting P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO31146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000188901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="887" mass="98190" checksum="EC5E04DA581831E5" modified="2016-09-07" version="1">MNSQTGIIMTLLGAAKGTTNKKNPNTVVPEEQINGATSKTGRKQSIDSAEYDCKLPKSVLQGKLSALAIQIGYMGFVVAGATVIILIVRHCITHYGINHETFKASDFSYFVNFIIIGVTVLVIAVPEGLPLAITLSLTYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQSFINEKFYKEYVPKFEQLDEKTRQLLIEGISINSGYNSQVLQPEKLGTQKTQLGNKTECALLGFVLDLGRSYENIRKKNPEESLVKVYTFNSVRKSMMTVIKISNGYRVYAKGASEIILARCSYILSAEGKVKPFDKQQRQEMTKNVIEPMASDGLRTVGLAYKDYVSSDKETAENDIKYEGEIDWEDEETVRMEMTVIAIIGIKDPVRPEVPAAIERCQKAGITVRMVTGDNINTARSIATSCGILKPGSGFLALEGKEFNEKIRDSNGKVNQAKFDAVWPRLRVLARAQPTDKYVLVKGIINSKSSKNREVVAVTGDGTNDAPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVTVAFIGACTISESPLRAVQMLWVNLIMDTLASLALATEMPTEDLLKRKPYGRTKSLISRTMVKNIVGHALFQLTILFAILFLGDRFIPDVENGRSMPHNSPATRHFTIIFNAFVLMTLMNEINSRKVHGERNVFKGLFTNPLFCIIWILTLISQVLIVQFGGAWVSTAPLNEIHWAVCVACAFGTLIWGQVLATIPSKVLPKFFSFGGGEVQPTSVLVTGEYDTSDGLVKGVSKEDQKRPGQMLWLLGLTRLQTQMRVIRAFQTNACTVHPNSLITSTAERLRTSYRRLQLSREREEQRSSSSHLVFVFVFVFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3G9</accession>
    <name>A0A183H3G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bromodomain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2029</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001091">
        <property type="protein sequence ID" value="VDO31629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3G9"/>
    <dbReference type="STRING" id="387005.A0A183H3G9"/>
    <dbReference type="WBParaSite" id="OFLC_0000202801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000202801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000202801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05511">
        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000066">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="610"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="721"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="800"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO31629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000202801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="909" mass="103967" checksum="FFCDB843D1B71BBB" modified="2016-09-07" version="1">MVTPEMCCAQYSMLAAEQRLKDAGYGEKYFFTPENEDDSDDQVTIEDEIKCAPWNTTRAYISSMKGKCLLDQTGIADPTGCGEGFSYVRVSAKPQKAKEEVTNVPKRLVTGTNADLRKLPLKEAKEICRDYGVREEEINSLSRWEIIDVIRTLSTQAAKARSDFSGMARFARGNIRFNFADMQEKYKKFCQRIFDLQNQTLSNTDILSTDEGSSGEDSDNEELATKLESMLDANKGKSFTFDKKKLEFEQEEKERKALQKMLCNDQPTGLSMSKHEKENDIKGKELDATPLFNEMQNSQIPAPSVTRKLKIYRTYRAEDGTETTRVEVITRQQLIDAYVRIRTRCDETFIRVYAQMDEQFKEERRKEKRRLQDQLRRIRRNELKAKLHGVPIGQPITKAKVTEKKPPVIKPNLLKMRCSACHGTGHMKTNKNCPLYGKDPTKAIRTVGDIHPVALTDEQLEKMAVPSGELIAVEGTKLKISRKLLHIPRELIEGDKKLTVEGDKGSPSITIEPEENTNMMHGIVNSEDVDPDDDIQISETPEPPKTSKVRITTVGSNKRRHTAEMEDYLYGPQKTVKRIRADPKVSMSIVLSEIFNDVRSVFGCEEIMFPVNPKKVPDYYNIIKEPMDLQQIKKKISENQYELRRQFLYDIKLIMDNSILYNGGGHPITIIAKNVFEMASRHIAEREQKLIALEKAINPLLDDNDIIGFSFILNEIVQECKNIPKSVAFHFKVDPKKLPQYYEKIHRPMDLGTMQQNIKEHRYTTIEAFRNDIKQIKVNSELYNGPPETSQYTSKAVEICTLAEKMLEERKEQLAELEMNIQSTLNEHVDLESNATSTICAEEVEEPSPGSRPDELESRLNENIVKIEPNDDEEVMPMGNLQDDLALSGDEDDLDDEDQDLGIFYSCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3P2</accession>
    <name>A0A183H3P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cmyb_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001143">
        <property type="protein sequence ID" value="VDO31879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3P2"/>
    <dbReference type="STRING" id="387005.A0A183H3P2"/>
    <dbReference type="WBParaSite" id="OFLC_0000210101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000210101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000210101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000210101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21194" checksum="30B67BBD83516B0C" modified="2016-09-07" version="1">MNIRTDMFALRDCHDSDNNVLIRPSSIMEESEHSDSLFCSACETFSMISTDPQNSESYFTPLEDIKECYFRRSKEVSIGSENLNEDSSTQTFSSSDGAAKNYGKKEVLQANSPDRPICSSPQKLLNSRLVTKHDATTPKYLSLQLQRPLACQEQKVPQKQANVNSNFLRIFNVEPQQLATPSATTVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3R1</accession>
    <name>A0A183H3R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2121</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001158">
        <property type="protein sequence ID" value="VDO31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3R1"/>
    <dbReference type="STRING" id="387005.A0A183H3R1"/>
    <dbReference type="WBParaSite" id="OFLC_0000212001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000212001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000212001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="537"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000212001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="868" mass="98811" checksum="37556CD5F76A5877" modified="2016-09-07" version="1">MTLQDSEYSSTSQGLLSDENLPTLTAIDLNVNPCVEDIRKRKALKMRNVVDESLQSIDMIKIEQSENRLRRSVGIGQNRNKIEIGWNRNTSNDSVGGKNRDENRSEIKCDKNFSIDYEKSNEHETEVKWIENDLEDWDCNKNLDESRKEAKWGRNFPTGQKDYGKMNKNERKVKRIKDTFKNQGDGDEVGQSGSKIKCYGNILTDQNDYKKPNKSRDEIKWNGNGFRNQNDNEKPNGSGDEIKWDGNILKDSDDIKESNGKKDKIKMNSNILIDQNDGERLDENRNKIKWNGNAYKDQDGDSDGKNDDVENNENVFGSENRDEVLNENGGEVEWNGNDLINQNEVEESDRNAEWNGQNGNAARHQKGEEESNNGFPRKTKTLGLLCRKFFLKVLEYVDSGDDKINLEVIACSMEVEKRRIYDVVNVMEALGAMEKSHKSFYTWKGLDNLPSTLHTLKTEAEKEGIYEKVLLTQHIMTRFMEVPNKNGNASPSEAGPSRTSDDKIISTLERSNSAGNKDGGSVSSKQSGSKKESKRQRGLNSLTYLCKYFFKILIVGLDYQPDYKVSLDVASTILIKDPEIDGCKPPDRSRCRRIYDVANVLISLRLIERRMFTFGTKKIPLFVYCGPNIIENGKFDFFYHIRFNKLSVKLKNSEEKKAYEVEEENLEIKEKKKEAESSVEINEPAKKRSRIEEIDPIRESTDFGKENIPSTLINQRIAPGSPMIVSIVRPQPQKVADLRSVLVPQTSSSFNALQSVVQQPRFTQFIPLPICPAGFLPFDPNIIFLNNGVSTTRIPMQHNFNHLNAYPLSSMAFSQQPRGPIIDTANRSYTAYNNSNSSFTSPRNILRPSLFNIDAILGNREAHDNNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H480</accession>
    <name>A0A183H480_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dystrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001285">
        <property type="protein sequence ID" value="VDO32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H480"/>
    <dbReference type="STRING" id="387005.A0A183H480"/>
    <dbReference type="WBParaSite" id="OFLC_0000228901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000228901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000228901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000228901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58166" checksum="3A75755FB5A3F71D" modified="2016-09-07" version="1">MIYLFTSKSGFFKRQKDYSNHHPKHPPRKLNTFSTENAKKSDDDDVNARDVELQQMIPRNKKERHKFFNINDKIDNLIDSLTSIEGEPTELEEKLAKVSEASRSPSPEDEQPSALATSTTPLYMQKHHSIFGTRKGSESISNPSNTVEATIFATTITQASSSGEAQKLPSTSALQTPQPALTSGNPTVITGDPLPFVSGSSTLPHSMTWGPHVTSGQFQSIQTLDQRGLPTVPYYPVCSIPVMAPSVSMPYGLSSPYLLSPYSTLPLPRNTSEQQSSTTNPNIPGSPLEGQDLTNYQLSLSLDQYNQHLIRSQLDQAQQTAQVASCQVQLLRDQLTSETTARIEAQSRTHQLLNANRELLEQVQSLVLRLQSLETRLAEEIQEQITQPSTSRGKSETATLLMKAPGPMPTAPLTASSPEQFKNEAKVPGPPPVDPSKPYQLQSLADIRAGSLPPQGIQSKATSSTKNLRTSDDLEIRTEPESGAEDTTDYSSSDQYEKVPFPSIPENPLPGLHLNILMSNPQVKLISNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4P2</accession>
    <name>A0A183H4P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2452</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001413">
        <property type="protein sequence ID" value="VDO33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4P2"/>
    <dbReference type="STRING" id="387005.A0A183H4P2"/>
    <dbReference type="WBParaSite" id="OFLC_0000245101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000245101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000245101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000245101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20920" checksum="AA5827DC8C915A89" modified="2016-09-07" version="1">MLRDPPIALSLPPIPKKQEIRYKETINEEGLLYHRTEEAPESLFYPSLSPSKLRSVSFIPVSSSSYSQSADGLSKAEMENLPINQLSTTTLRKIRTINTPSISELARLFKSSSPAKEKRGTRERQLLKKNCSVHECVYPGCCKKYNKSSHLKAHMRTHSGERPYCCSWPSCRWKFARSDELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Q5</accession>
    <name>A0A183H4Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS2465</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001421">
        <property type="protein sequence ID" value="VDO33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Q5"/>
    <dbReference type="STRING" id="387005.A0A183H4Q5"/>
    <dbReference type="WBParaSite" id="OFLC_0000246401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000246401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000246401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="586"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000246401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="751" mass="86560" checksum="72FDB4478DAD1F2C" modified="2016-09-07" version="1">MVYSTCSLNPIENEAVIASILRFGAGALELVDVSQQLPQLKRTSGLSKWRVFDKTMREYDALEDVTTDQRRYFTSSMFPPNDEEIQKFHLERCFRILPHMQNTGGFFVAVLRKSKPLSQSKLAFNLSSVKRRRTFKEDPFVFLEKDDTRWKDIASHYGVSEIFPYQNLLCRTTEADKKRTLYFVNNAVKQFLLCNQDKVKVINAGIRMFGRVENKYNLCRFRLLQDGVRTILPFLGKRIVEISVEDMCKILNSENGNGNCPRDELACDEKFRNISSGSVVLVSEFNGLKQVICAWMGAKSLAPYISREGKVHALRMLNCDTSNFERIMWTKRQSKAVYDREEAKKRRILEKLDQFEEEKILNNGCSETIGKNGKDDESSDSQFNEIEDKMKRSALTDELFKKLTFGIKRSRLQQRKENSWCSLLLILIRVMTIGVLEMELETHGLLHVRLLPNDCKEEYKESKERNNEASSSLVTSEKEPEILGGLENVSKKKKKNRSLAMKREQIAHLRKLNRIFVWGDNIPDPLIHFIEIDGLPQELVNNLREFGITEPTPIQMQAIPIMVQKRDLLCSAPTGLFFFQEFFSCSGKTLAFALPIIFDVICRKNHIAEDRYPVSHAAVLEPTYELAKQTYVQFLKFSQNLPVSCSFLEGEEIPTNADVIVSTPNKLVYALKKNKKILDGLNWLVIDESDRLFDTTEGDNKCFRSQLAKIYQACSGNFLRRAFFSATFSYEVEDWCKRNLFDVAMVCIGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5G1</accession>
    <name>A0A183H5G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein EFR3 homolog A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2721</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001631">
        <property type="protein sequence ID" value="VDO33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5G1"/>
    <dbReference type="STRING" id="387005.A0A183H5G1"/>
    <dbReference type="WBParaSite" id="OFLC_0000272001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000272001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000272001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000272001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70597" checksum="D59173A274C3EBFC" modified="2016-09-07" version="1">MCHASNSETSKDARYAGLRGLRGVLWKSTTDPLQTSIWERQYMDKIIPSILFNLQEEDSDESKEKRNKRFSVIDQPYVMDGVAESPRALADQFIRELMAKAPFGLVSVLDPVLKHCDLHMKWEPPPIFAVYIFRAIMYSVKDPSFVIQALITHLENMSNSNASVRIGIATVLSSIVSIANTSIGPSLIGIFNSLLKHLRRSVEFQQIEECPSVDQEKIYQESLINTMGDYAYTLPDYQKVEIMLFISANIPNLGKDSQSLKPSDTFLQHILVKTLLKVATKYRTGFMSTIFGNNFPNTLLRLALTTDPVVRLDTQYIFHTLLDRHDNLPVLRHLPYVNDVTDLQLTFEKCSRSDEMIMRNYAPHLLNALHKYVWMIPEDETQGEHMDAILCTMALLCIEIGFDEMLIQLFRLSFALQSMALESSFHFNGAKRIAIHNLVAKYLNFSSQLMAIPSLCQHVQQVVKQRALRGHPLLNLLPESQSDKKSPKKAPLACYDDEEQAALCLEEDATILFDINDVSEMLKATGKDVKNLTVAFISKGAVLASSISGDIVNKDWPFREVEKMNNIDGTDNSGIDENTISLDISIDWSQSDSVQTSRKNTLFPSARGSKNLYSERKVLLLIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6A7</accession>
    <name>A0A183H6A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDEase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3018</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001891">
        <property type="protein sequence ID" value="VDO34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6A7"/>
    <dbReference type="STRING" id="387005.A0A183H6A7"/>
    <dbReference type="WBParaSite" id="OFLC_0000301701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000301701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000301701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000301701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17904" checksum="997974EE678E5263" modified="2016-09-07" version="1">MSGLRRRRTQITDQTVSEGDVEISSSLRQIFEKVTNEVMNRHIIPEFNRRTMEYQQWIFDEQKKAEQILKDGGYTLPRIRRINFCPDDFLNFLEMTNKDKRSNENEACYAVNGLTRQKVHLRSSSSRYWRTTSSPSIDDYNNLSPLSTGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6C3</accession>
    <name>A0A183H6C3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA-processing protein UTP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3034</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001905">
        <property type="protein sequence ID" value="VDO35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6C3"/>
    <dbReference type="STRING" id="387005.A0A183H6C3"/>
    <dbReference type="WBParaSite" id="OFLC_0000303301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000303301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000303301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09866">
        <property type="entry name" value="PIN_Fcf1-Utp23-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000303301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37589" checksum="DFA8CBECD6BD9DFA" modified="2016-09-07" version="1">MVIPVVDMLNERKLNKYAIYLSKCSREVGVHFTSLHGFTPIGRFLSAIDYGKCVGEKAGKVTHLACQREFELLLKCVEKQSFTDSGSFYEMKVKRYKRAKRIISIYRHNFGFEPPYQVLLDGTFAMAALQNKINLREQMPKYLNAEVDIRVTNCVLKELEKLGPTLYGALHICKQFDVESCPHQPMRTAVECMKHMARRMKSRTTFFFATQDNELTEALKQIPGIPILFIKYNAILVDKPSQATIQEIEKPKDELLEINELKKALFGESEKPRRKRKGPKGPNPLSVKKKKRKIQLTNNEQKLESSAKTAASKRRRRRKKMEGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6U0</accession>
    <name>A0A183H6U0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3201</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="UZAJ01002068">
        <property type="protein sequence ID" value="VDO35643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6U0"/>
    <dbReference type="STRING" id="387005.A0A183H6U0"/>
    <dbReference type="WBParaSite" id="OFLC_0000320101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000320101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000320101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO35643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000320101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46825" checksum="55206B1C7CF63B15" modified="2016-09-07" version="1">MKDNDYSRNDDNSGNNAYAGITAAIVLFLVVSGLTFPNGPFIRPHPVFWRIIFGMSVLYILMLQFALFQNFRDIKDVLKWLDPQGLSKEKLDEKAYAVNCSDITLTRLWNYMDIFALGHFVGWAMKAMLIRHSIICWYISIAWELTEVFFAHLLPNFKECWWDAIILDILLCNGLGIWFGIWLSHFFEMRQFHWESIKDIKTAGGKFKRAVLQFTPESWMKVEWYNNCALRRTLAIYLFVLIWLITELNTFFLKHIFAVDTSHPLVTARIILIAFISAPTILQFYLFATDPRIKRVGMQMWVYVAICTLEASICIKFGHSQFSHINLTFIILWISFMAVGTFACVWMSVWWIKMFTKTEKVNINGCLRDCYLDSSHENLGALTEEVKAHRKRLNISESDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8F9</accession>
    <name>A0A183H8F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3770</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002628">
        <property type="protein sequence ID" value="VDO37688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8F9"/>
    <dbReference type="STRING" id="387005.A0A183H8F9"/>
    <dbReference type="WBParaSite" id="OFLC_0000377001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000377001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000377001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO37688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000377001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14188" checksum="A8D7D1B48CE59125" modified="2016-09-07" version="1">MGTSKRSQSESSGLTNSSRTSSSAPMPAVPARYILKPGEYLHDIGESETLNAFTRRVCSMSVYGLFFDYATVISKDSKDLAIFSEKYKALNRYNDIRCLEQTRVKVPLVPLYLMNLILSVIFFPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8U9</accession>
    <name>A0A183H8U9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002782">
        <property type="protein sequence ID" value="VDO38191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8U9"/>
    <dbReference type="STRING" id="387005.A0A183H8U9"/>
    <dbReference type="WBParaSite" id="OFLC_0000391001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000391001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000391001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000391001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10838" checksum="B4016CF0BB97F5B9" modified="2016-09-07" version="1">MSHIPVTGGSHGADDYRRNVEYPRYCDLCTRNVRKFSNRYEFAQHLRVMHCTKEGGSFICRYGPNGVCQTLPLEGVSDHDYETHIRKCHADFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA37</accession>
    <name>A0A183HA37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4349</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003259">
        <property type="protein sequence ID" value="VDO39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA37"/>
    <dbReference type="WBParaSite" id="OFLC_0000434801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000434801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000434801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000434801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26319" checksum="FE8D1AEC3E32325B" modified="2016-09-07" version="1">MAAPLSKRNEALEFTTISADSIKNLKLQLIGWLLIIGNLITLSILLIMDSQFADAAMNYSFFFFVYIASLICTVFALKDSKSMMLYPILVISMAFVFFALSAWIFVLFNEFYCSHSSNLYPLLIYNGTIFSQCQIQWSISPLQSALLLLVAFEKLFEFVIFRRLMKIFELQRLNNVHFCVTEINKAFSKHNDTDDEIYSMISMWKLNQDEQEKTKRNHQNEVCRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAA8</accession>
    <name>A0A183HAA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4420</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003345">
        <property type="protein sequence ID" value="VDO39949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000441901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000441901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000441901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000441901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16970" checksum="EBF20DF8EB6CA65E" modified="2016-09-07" version="1">MDNLVYHPKPRKWSLLNKMINKMIIIVFFYAISVEIRRLKDVPKGKVFENKEKKERNEDFSVKNPMPHEDADVKILSMTDSTMIPIYKRTEFYVLSGGVALYWVILIFIGLIIAICRNKFRRAKDEHKGHQKNEKKDERTEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAQ7</accession>
    <name>A0A183HAQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHASE2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003527">
        <property type="protein sequence ID" value="VDO40364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAQ7"/>
    <dbReference type="STRING" id="387005.A0A183HAQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000456801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000456801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000456801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000456801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22446" checksum="58F78031A5A7EB1C" modified="2016-09-07" version="1">MLTVYFLQVFPYRACDIKRKGYDRTLIDHIAVVFFDDLEPFITGCVSLDNQVRFAEKSGALGLVVGPQSRVVAQIDKTQRGRIPVVMLDDLETKRLKKQLSEATQSGSIIRIAFEYVDFEPQYTLRLQVFRPTVLNIGLIILLILLILFITGLVYIKIRWRPSTHRDIWLRTLARLIFFSIFINKYFKISLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW6</accession>
    <name>A0A183HAW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleosome assembly protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4628</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003610">
        <property type="protein sequence ID" value="VDO40555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW6"/>
    <dbReference type="STRING" id="387005.A0A183HAW6"/>
    <dbReference type="WBParaSite" id="OFLC_0000462701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37177" checksum="C8EB01297D3BC411" modified="2016-09-07" version="1">MESKNDMGELVKPNGYDTENKEYISCLPKSIKRRIQALKKLQVEGINVEAHFYERVHQLEVEFAPMFSALHNKRKAIVTGNYEPTDDEADFPILRGYTKEEIEQMEEASSPEPKQPTKGIPNFWLHLLKNVDHICEMIQEHDEPILKHLIDITCDVQTNPDSYTLTFHFEPNEYFAQTELKKYYTLQVAPDEDDVFDYDGPVIINTKGTEIDWKDGKNVTKKVIKKKQKKGTSAGRFITKTVKADSFFNFFDPPPMKNKNEINEDDDDDVTEELLQADFEVGQLFRDQIVPRAVLFYTKEAIEDNDIFEYDGDEDEDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBQ8</accession>
    <name>A0A183HBQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS4920</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Synaptic cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003984">
        <property type="protein sequence ID" value="VDO41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBQ8"/>
    <dbReference type="STRING" id="387005.A0A183HBQ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000491901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000491901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000491901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="11">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000491901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18921" checksum="A8E688FA4A984CBC" modified="2016-09-07" version="1">MHDNNNTNEITDEQRLLRYLLNHYEKAVRPVRNASNTVVVKMGMTITNIFDMDEKNQVLTINVWLDQEWRDELLVWNPKEFGGIESVRVPCDLICADDYTIGSMNSRAMLFYDGIVFWPPPTQLRSTCKTDVTYFPFDSQHCAIKFGSWTYDGIEKFNALMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBS5</accession>
    <name>A0A183HBS5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4938</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004005">
        <property type="protein sequence ID" value="VDO41512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBS5"/>
    <dbReference type="STRING" id="387005.A0A183HBS5"/>
    <dbReference type="WBParaSite" id="OFLC_0000493601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000493601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000493601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000493601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10749" checksum="A908EF6DD6B50743" modified="2016-09-07" version="1">MRNKLVVFGDISGGVVLGDSDRSALMCHRGVTGIFKRRMNEGQTVRQQGPKPAGRLYVKAIFAGYKRSQRNQHEHTSLLKLDGVYNKQDAQWYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBX9</accession>
    <name>A0A183HBX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4991</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004078">
        <property type="protein sequence ID" value="VDO41695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBX9"/>
    <dbReference type="STRING" id="387005.A0A183HBX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000499001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000499001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000499001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000499001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59330" checksum="DF1B311CA98C7282" modified="2016-09-07" version="1">MPPYTDAHVTSRYSISDKQLIRQSTKLISIPEPSCNNVTVRHSNRQHVEALALVTCAIFCDNDYDKESGTSDRNTTDQDEGINDGRYVGIGRCYNSESVDNNDGSNCADSMQEWRKIKICNDERQRKKLAGFRGKQWSKKRDKINQFIGSFILFISTLQVSLACPQIVTSICHCVDSQNGIILKCSHTDGSQVVRMLRANQINLGLVQQLEMQDSGLKDIPAGFFSGLFIKKLDLSYNSITDIDENSFLGMNNVLQELILHHNNLTQLPSKALTPLSALLRLDLSNNSIGDIEAEHAFPPLSKLYDISLANNRICQIHKNAFDDVKYSVQTINLGRNCLKEVPAPAIRGFKQLMALHLHNNNINSLGALSFMNLPLINLLNLASNQISTIHKQTFLNVPNLRYLYLTRNRITDILPHQFSSFEQLEMLDLTGNYLIELRENSFSNLKNLRQLYLGENHITSIKPNSFANSSMVILILNSNRLVELQEGMFNGLTKLQQLALKDNQVCFLYGKEKSYQIFFMERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCI9</accession>
    <name>A0A183HCI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5202</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004343">
        <property type="protein sequence ID" value="VDO42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCI9"/>
    <dbReference type="STRING" id="387005.A0A183HCI9"/>
    <dbReference type="WBParaSite" id="OFLC_0000520001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000520001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000520001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000520001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10338" checksum="BA3E1A8339FC72BC" modified="2016-09-07" version="1">MINIGPIPQWRTPKSTTASPIMPIIISPTTVTSTTTPTTNERMMAVTTNNNNNNKNNSNSNNNHNNIDCDIENSPNDSKRSKSSEKSWENSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD43</accession>
    <name>A0A183HD43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004627">
        <property type="protein sequence ID" value="VDO43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD43"/>
    <dbReference type="STRING" id="387005.A0A183HD43"/>
    <dbReference type="WBParaSite" id="OFLC_0000540401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000540401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000540401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000540401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16344" checksum="1A71CF34C84AA97F" modified="2016-09-07" version="1">MERRNLSRLNSSSTEFKNLIELARNIIANNDCLDVNRLEVLSEKIDVYAINQMVRHGLRDQADWPKIRGKQAELEIMYFEINVTVPVITRNPENQRIFVLFRVKHYARAGSYALVSDPYVYRNEFGCAAKKLQTFCSRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDD3</accession>
    <name>A0A183HDD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RabBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5495</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004755">
        <property type="protein sequence ID" value="VDO43346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDD3"/>
    <dbReference type="STRING" id="387005.A0A183HDD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000549401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000549401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000549401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000780">
        <property type="entry name" value="Rab-3-interacting molecule unc-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RabBD" evidence="3">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO43346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000549401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15788" checksum="93071B308394D6C1" modified="2016-09-07" version="1">MAEPPMPDLSHLSAEERQIIEEVFQRQREEEEKETQLSQKADQELEAIEKQINQRKEIAQRLVGTHDDAICQICQVTKFVDGIGHKCFYCQLRSCARCGGRTASKNKVSVNQSILQNTVIKFLYELLLDISTFYIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDJ9</accession>
    <name>A0A183HDJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004843">
        <property type="protein sequence ID" value="VDO43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDJ9"/>
    <dbReference type="STRING" id="387005.A0A183HDJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000556001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000556001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000556001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000556001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10479" checksum="B318C27A0DACBC3D" modified="2016-09-07" version="1">MQPGFYDIETEMCTPEIDDVKHYIPPEIEKNIIEKRPVTNISMFITVYLMDLEQNSKESYTSEFAKALLRRRMAQNTIACFLMGIDVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDS4</accession>
    <name>A0A183HDS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5636</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004949">
        <property type="protein sequence ID" value="VDO43805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDS4"/>
    <dbReference type="STRING" id="387005.A0A183HDS4"/>
    <dbReference type="WBParaSite" id="OFLC_0000563501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000563501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000563501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052667">
        <property type="entry name" value="E3_ubiquitin-ligase_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156:SF10">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156">
        <property type="entry name" value="PROTEIN CBG20824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000563501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11596" checksum="A4F6CE63A5459D5B" modified="2016-09-07" version="1">MSNISDVGLECALCHENYAAEIRTPRVLHGCGHTVCQTCCSALVDVSAPIAQVVCPFDRTVTLLTEPCVFSLKKNYALIEIIERHKNFTQSDRISPLLVSVLHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDW5</accession>
    <name>A0A183HDW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5677</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005008">
        <property type="protein sequence ID" value="VDO43934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDW5"/>
    <dbReference type="STRING" id="387005.A0A183HDW5"/>
    <dbReference type="WBParaSite" id="OFLC_0000567601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000567601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000567601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000567601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29613" checksum="D1F003373E9FB983" modified="2016-09-07" version="1">MNTPLLYPDKSVSTFQSARSDFAYANSKNKMDEAVVHSKMIKEDPTSPLSSENDFDLSAWGNENEKDHNSLSFSLPVSTKTGKTSTPEEIFSQYWVTGIPSYTLIECRNMIRVLVQACKHAVHALKDTHATNYAISPDHEAKIIEQLFHYGLRCLDIYVICPISNQVPSTQQRFSNGVRTKEEKEVLELFGSIFTLLNPSIFKEIISKRIDYFIERLASNYGLQIICSSLLVNSLTSANFGDILIRFLMKKLPDLAGELLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF71</accession>
    <name>A0A183HF71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005666">
        <property type="protein sequence ID" value="VDO45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF71"/>
    <dbReference type="STRING" id="387005.A0A183HF71"/>
    <dbReference type="WBParaSite" id="OFLC_0000613201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000613201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000613201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="1">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000613201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27680" checksum="0796B1371EA125EB" modified="2016-09-07" version="1">MFTPYMELPVSNGSDADIMNAELNYGNNFGYYGLQANLSPALCERMLCNERAKELQEIQVGLEQLILEPGEFETWSNAIRERTTNPLFKIDALKITVEMIIQLAAFTSSSQTVQYNLAKLCSFLCSDLQTFQDDMIASLLCFHEEQRSNLNDQQRKNLLLFFAEIYEKLKSKKSSKMQAFENAILEQIKEVLTADRLDDSKVKVVVEVLKLTGRYLDTDEGTSKINELLTQLNAIAKAHPAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF98</accession>
    <name>A0A183HF98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005709">
        <property type="protein sequence ID" value="VDO45623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF98"/>
    <dbReference type="STRING" id="387005.A0A183HF98"/>
    <dbReference type="WBParaSite" id="OFLC_0000615901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000615901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000615901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816">
        <property type="entry name" value="MIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816:SF4">
        <property type="entry name" value="RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000615901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25132" checksum="C8133420D4C1B24B" modified="2016-09-07" version="1">MIQSLGQLQEELTRKSFTKNYYRVAECIRQLSRCAEENGVMLPVNGCMPSVSAETTAKQHWQSAFNSVRFISQANKRTKTRLNVPDYVRVAESFSDVVSCYEAMVAEFKMFALPLQTAETSVLVDVFHAPERLFTPGSDLYQECENGGVIAKLIQHCKSLLQHEQKTLCVRVLQTLCRMASNAKYNFINQLKYLLPDGPMRSMHFTFALSHNDYLVTSNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGU8</accession>
    <name>A0A183HGU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6709</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006542">
        <property type="protein sequence ID" value="VDO47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGU8"/>
    <dbReference type="STRING" id="387005.A0A183HGU8"/>
    <dbReference type="WBParaSite" id="OFLC_0000670901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000670901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000670901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF50">
        <property type="entry name" value="PROTEIN TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000670901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19068" checksum="4B097A31A42F5451" modified="2016-09-07" version="1">MVTRRRSNRRKGDNPEEALQQRVAANRRERQRTKELNDAFAILRRIVPSLPSDKMSKIHTLRIATDYIRFLDQMNGDGCRLFGCEMQLCDGNLQTTFNMWRGGMASLPHYYSNDTSPMQTFIKTEEEHGWFSEDTDATLPATATAAATASGMPAVKKTTTSLEQRTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI84</accession>
    <name>A0A183HI84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCDC92 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007340">
        <property type="protein sequence ID" value="VDO49754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI84"/>
    <dbReference type="STRING" id="387005.A0A183HI84"/>
    <dbReference type="WBParaSite" id="OFLC_0000719501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000719501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000719501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000719501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15682" checksum="A24C9CAEB165819E" modified="2016-09-07" version="1">SYICDSPTQTSGSSIRRATSFHTGSSPLIRKSPDMVTTCFHEYRSSPPQFQLQRLLDAFEKEQKSFNDESTRSIRALEERCRQFADNQAILQVRLLEKDSEIELLKVQLNTSIAVDEQLRLTKTKLDTEVIHFPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIG5</accession>
    <name>A0A183HIG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7278</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007482">
        <property type="protein sequence ID" value="VDO50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIG5"/>
    <dbReference type="STRING" id="387005.A0A183HIG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000727601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000727601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000727601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057589">
        <property type="entry name" value="GT_PLOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25342">
        <property type="entry name" value="GT_PLOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552541" evidence="2">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PLOD1-3-like GT" evidence="3">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000727601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27301" checksum="FCA9755875FF070A" modified="2016-09-07" version="1">MYSLVIWLLFLVSSSLTDKCDSSVYKLIIFALSNGNNDALERLRCSTERYNIVFKIFNFGRSSTNQHESRKDSKLLRMLTTELNLYGASNSTILLIIDGFDAIITSDENDIICQFLDACSNCRALLTSKMISKQENSSFELLFSEIRSVALIGFVPNILNVLHFVGSQDDKVLSYSSLYSDDSVNTLGLTFDVKRILFQNIDSASSEVMLSFHDSGDAYVSLYFLSKVVPVLLFYFILFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIH2</accession>
    <name>A0A183HIH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007487">
        <property type="protein sequence ID" value="VDO50208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIH2"/>
    <dbReference type="STRING" id="387005.A0A183HIH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000728301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000728301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000728301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000728301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22539" checksum="C674E568546AAAA0" modified="2016-09-07" version="1">VTIEERKGRSGYQSFVITAVRAAFGITTTVLRTTANVMSPEQQLRLLYLYDEEIIKRIAVHHVEAINFAHLLKPNEYETLLEQYHFSWNTFAVKLWERLWKAPTRILLFETVLSFLVPCDPKLHRRLSCMDLRSNLSDLNEILKNIDGILNNMDPYIVCEKISCISRHHANLMMPVKNTIEKLGESLCFCYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIZ8</accession>
    <name>A0A183HIZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7460</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007812">
        <property type="protein sequence ID" value="VDO51121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIZ8"/>
    <dbReference type="STRING" id="387005.A0A183HIZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000745901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000745901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000745901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000745901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28211" checksum="385FE1F0334467CF" modified="2016-09-07" version="1">MDLCLLLANRGASYLRRLWDGDAYAALLDLIRALKIEPRNSKVHYRIIKALIELKQYDMARRISKLFKERFPDDHSCDRLDALLRTDPMGQKSWTSNGCSDYVQRLCGHCNTNTDIKEAVWFGSRDEYIAAGSDCGSLLIWERKSGALIKGFEADMNILNCVQPHPSILLLATSGIEHVIRFWQPLDEDLERNSTETGRELHRLTALSATNQKRMHTGIFDMVVASIGLAVQGGDDDDVERGRRIGCNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKS3</accession>
    <name>A0A183HKS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8087</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008880">
        <property type="protein sequence ID" value="VDO53981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKS3"/>
    <dbReference type="STRING" id="387005.A0A183HKS3"/>
    <dbReference type="WBParaSite" id="OFLC_0000808401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000808401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000808401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF16">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO53981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000808401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29913" checksum="B254D4D646CB43F8" modified="2016-09-07" version="1">MRKKAAVEEESKKENSAPPIEIIEDIPDEVKPFLDRRILPRRSARSAAINQLKELTAPLKPQSGKRKSQQNKKQMEIENAKQLKILDKNDYQDDSEDNDENEKDENDADDFILAETSTSSDDDFMPLSELKKKNQNSRRRRGRKTTVEKDPFEMVESEEDEDSDDDQEKKAKKERKKATEETLCMKCSKSSNPEVLLLCDLCDEAWHTWCLHPMLWYVPDDDWFCPNCQQAMLIKKFSEVLTVLAEQVKRKAAEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL18</accession>
    <name>A0A183HL18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009038">
        <property type="protein sequence ID" value="VDO54392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL18"/>
    <dbReference type="WBParaSite" id="OFLC_0000817901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000817901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000817901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000817901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6824" checksum="ADEDDDBE4DB5B423" modified="2016-09-07" version="1">MKHIKHIVIMMSCQSLIIILIIIFIMDITIDGLPRMNTIMDMDLEHGIIQQNGVMVGDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLD1</accession>
    <name>A0A183HLD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino_oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8294</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009252">
        <property type="protein sequence ID" value="VDO54987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLD1"/>
    <dbReference type="STRING" id="387005.A0A183HLD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000829201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000829201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000829201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000829201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12162" checksum="30B58FBAEC408F14" modified="2016-09-07" version="1">PPKTLPRRIIVIGAGIAGIIAARQLRSFGLDVILLEARSRIGGRISTYIKPLTGATSVENKSRDLIVAELGASFIYGTLLNVQSAFIPRLTYNVQSVFTVDLEILAKSFNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM33</accession>
    <name>A0A183HM33_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 2</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8543</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01009758">
        <property type="protein sequence ID" value="VDO56185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM33"/>
    <dbReference type="STRING" id="387005.A0A183HM33"/>
    <dbReference type="WBParaSite" id="OFLC_0000854401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000854401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000854401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="140"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO56185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000854401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27748" checksum="A3F69EA0242A9E91" modified="2016-09-07" version="1">MLLFQGGRHVDYVADQITAKLIDTIKKKIGKSGVNVKPFQIKSHMWIFVNSLIENPTFDSQTKETMTLQAKSFGSKCELSERFINAVMKCGIVEAVLAWVRFKQQETLDKKCSSKKTSKLKGIPKLEDANDAGTKNSSLCTLILTEGDSAKSLAVSGLGVVGRDRYGVFPLRGKMLNVREGSHKQIMENAEINALIKIIGLQYRLKYDKDEDMKTLRYGKIMVMADQDQDGSHIKGLVINFIHYNWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM53</accession>
    <name>A0A183HM53_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009810">
        <property type="protein sequence ID" value="VDO56300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM53"/>
    <dbReference type="STRING" id="387005.A0A183HM53"/>
    <dbReference type="WBParaSite" id="OFLC_0000856401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000856401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000856401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000856401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19416" checksum="F3DD7A4BC84D16D4" modified="2016-09-07" version="1">MIRTLTSNSSADQKELDRRRLEAGFAETSKEIDQLVLACREKIHSIRSSLLTCRSLLQCRRDDLKRLWMENAQQKHVSTILAQIEGLNRLGSEVEAAMATSNYHLAANSLNEADLLFNGPFSNIDGLNQLRSQLLDLSKKLIEQIVNDITNHLIVRPFENHSPKTSLMCSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMZ7</accession>
    <name>A0A183HMZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8858</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010367">
        <property type="protein sequence ID" value="VDO57760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMZ7"/>
    <dbReference type="STRING" id="387005.A0A183HMZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000885801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000885801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000885801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO57760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000885801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19978" checksum="24E7709271F29704" modified="2016-09-07" version="1">MNGYYRNGPRFDRIDQEEVPESKHTVFIRGLPGHIKTDEVKDFFEDHVGPCSFDFIKLSQDQLKLFVAVRFETRDAAKECMHKYKDGDVLGYPVEMTWFRDIRRYVSYQQSQGNLLLFIMTISVKCYSEAFIEISLRPAKIPRSRGYGGRNRTSYDHSARNDYRYEDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN56</accession>
    <name>A0A183HN56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8918</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010479">
        <property type="protein sequence ID" value="VDO58015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN56"/>
    <dbReference type="STRING" id="387005.A0A183HN56"/>
    <dbReference type="WBParaSite" id="OFLC_0000891701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000891701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000891701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000204">
        <property type="entry name" value="kinesin-like protein unc-104 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO58015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000891701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15943" checksum="3BD5FC818778B398" modified="2016-09-07" version="1">NKLRSKSNQNLVHSSNETDDGIHRSSSGSRISQMSLLIPEVTEERVGIVVSKKGYMNFLEEKTQGWVKRWVVVRRPYILLFRDDRDLVIRGIINLANARVEYSEDQQAMLKVPNTFSVCTNHRGFLMQIVDDQVSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNG8</accession>
    <name>A0A183HNG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9029</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010691">
        <property type="protein sequence ID" value="VDO58427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNG8"/>
    <dbReference type="STRING" id="387005.A0A183HNG8"/>
    <dbReference type="WBParaSite" id="OFLC_0000902901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000902901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000902901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="118"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000902901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34927" checksum="120147C94A5F3119" modified="2016-09-07" version="1">MRKKIGVSQTTNEILRELVNELAIPVEEEVELSFDAGNGYGIRTLQGPECVFCIVMEHVKNTGYRLSEIQLEKIDAVPLIQCRLVLASMGNIHSSTSSIVSHFKRVLSRSESRRFFARPLEGSSPPQPVLTMIDHLMLHGVDVEGLFRKSPKQSTVRMLRAQLDRGSVPDFYQFNPHVTAALLKEYLREIPGKLLLSGNFELWASAMEQTMNCQKAVRKLLHMLPSAHYALLSKFLRLLRAIANSPQSKMTAQSLAVCIAPSLLDNPSKSMFSFTTKLLHLWIHKNCIFFTLNLTIISTFELLSDMVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNL3</accession>
    <name>A0A183HNL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAR1-RELATED SEQUENCE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9077</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010776">
        <property type="protein sequence ID" value="VDO58612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNL3"/>
    <dbReference type="WBParaSite" id="OFLC_0000907401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000907401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000907401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000907401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12459" checksum="6D2C4284C09A419B" modified="2016-09-07" version="1">MLNSTDDEKSWKTLREEGEFNTDEEFFAELADQRNSLSMERSECVQMKWIRPDEDGLTFEFCTLTLNLDTTWMYNIVDALLKERNIYHDNAIKGDTMVAGMERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP68</accession>
    <name>A0A183HP68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9284</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011230">
        <property type="protein sequence ID" value="VDO59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP68"/>
    <dbReference type="STRING" id="387005.A0A183HP68"/>
    <dbReference type="WBParaSite" id="OFLC_0000927901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000927901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000927901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000927901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21141" checksum="03ECDA2034FF7953" modified="2016-09-07" version="1">MGWITRVPSPIDHSAITMRQSVSCHDQMITSYVDCVIQNHYNRCSSPDCRKYASKPEIMKQSMNSISDTSDDEWIRCADDATLDESFVSDRIENDICSHIAVPIFPTRNVDNNSSINNDQQCNDLQCMDATEQIDNDNKNEETTKKCERPTGFLTTLKKIADEEDLIKITTNAKNNRTNEQFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP87</accession>
    <name>A0A183HP87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011253">
        <property type="protein sequence ID" value="VDO59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP87"/>
    <dbReference type="STRING" id="387005.A0A183HP87"/>
    <dbReference type="WBParaSite" id="OFLC_0000929801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000929801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000929801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000929801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11027" checksum="2375E0E265606887" modified="2016-09-07" version="1">MMAKDTALNQALTKSCRPVISKYCQQYINEEIDHGDVLQCLLDNKGRPEMTSKCRSYVNHFELITLRDFKFDERFAQYCSNDIKKYCTEVSTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPW2</accession>
    <name>A0A183HPW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9524</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011758">
        <property type="protein sequence ID" value="VDO61175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPW2"/>
    <dbReference type="STRING" id="387005.A0A183HPW2"/>
    <dbReference type="WBParaSite" id="OFLC_0000952301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000952301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000952301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000952301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28582" checksum="254AC5473DF3269D" modified="2016-09-07" version="1">MKQCEDTSLETVEKFQQLKPHLEELFKFWREFENTVAKIEERIKRSEREKRNLVDGDGKELLRHCEKIQDDIARFANDQIQQVISSRLSELKRRISDINRKIPTKAAQSLQGNMLSEKRTKVILPSGENIAAPALDTQDLEHNRLQKWLIMARQQMSTVVTDSNTLKQAINQVASCLREVQEVENERMALLKTRAANNEQNIGEYRKLRSDLQILLQHMKNVQPLFLSFDKNYDILLNRLNNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPY3</accession>
    <name>A0A183HPY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">REJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011819">
        <property type="protein sequence ID" value="VDO61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPY3"/>
    <dbReference type="WBParaSite" id="OFLC_0000954401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000954401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000954401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552593" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000954401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="14484" checksum="84E33E675D9B5456" modified="2016-09-07" version="1">MSCATTFTSISTITLSLSMSCATTFTTFTTFTNVTSTSTITLSLSSAAALSMSTEFSYAATFTTSTTSTTSTTSTTSTCISAIALFLSSAATLSMSTESSYAATSTTSTTSTTSTCNPAIAVSVSVPLLLRQSMQITISKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ00</accession>
    <name>A0A183HQ00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011861">
        <property type="protein sequence ID" value="VDO61503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ00"/>
    <dbReference type="WBParaSite" id="OFLC_0000956101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000956101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000956101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000956101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6308" checksum="02C095F300BE80F4" modified="2016-09-07" version="1">MLQLLIIGYLIYEIIRLSNLPDAGIYAPPQQPPSLPVFFSNSVKIAFASFFCIQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQV9</accession>
    <name>A0A183HQV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EIF3_p135 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9873</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012591">
        <property type="protein sequence ID" value="VDO64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQV9"/>
    <dbReference type="STRING" id="387005.A0A183HQV9"/>
    <dbReference type="WBParaSite" id="OFLC_0000987001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000987001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000987001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF10">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLU central" evidence="1">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000987001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23332" checksum="943674E708915062" modified="2016-09-07" version="1">MICITELLCRCAKHIFRSYLQPVSSAHTAAAVSHFLNCLLSSSTEPLVPSNEEVLMPINGVRKSRSAKRRKQINNGGKENDDWAQLSSHKLWERVKSDANFYYAFTIDEENVDTYLSTIGIQKTSFLRRFTQTVGIQVLLRDYNLETGKKSQLFVEDDIQGLYSLAKHVDPKAMDAHSLFISGQTKVQQGIFYNSILFQLLFECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQX3</accession>
    <name>A0A183HQX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9885</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012614">
        <property type="protein sequence ID" value="VDO64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQX3"/>
    <dbReference type="STRING" id="387005.A0A183HQX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000988401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000988401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000988401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000988401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11079" checksum="7A5E3F9805554499" modified="2016-09-07" version="1">MNPPFGTKNNAGIDLHFVEAGLSILKKNGTLFSLHKSSTRQYIAKFVSQKLSGISGECIAELRWNLPATYAYHRRKSVDIEVDLWQFSFDSEDISVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRP3</accession>
    <name>A0A183HRP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AA_TRNA_LIGASE_II domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10154</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013252">
        <property type="protein sequence ID" value="VDO66259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRP3"/>
    <dbReference type="STRING" id="387005.A0A183HRP3"/>
    <dbReference type="WBParaSite" id="OFLC_0001015401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001015401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001015401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001015401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14337" checksum="0C38A1717CD2B2EA" modified="2016-09-07" version="1">MKADMIEYYDVSGCYILRPWSFAIWEVIKKWFDTEIKKLGVCNCYFPMFVSQNALQKEKEHIADFAPEVAWVTRAGNSELNEPIAIRPTSETVMYPSYAKWIQSYRDLPIRLNQWCNVVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSK4</accession>
    <name>A0A183HSK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotran_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10465</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013973">
        <property type="protein sequence ID" value="VDO68689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSK4"/>
    <dbReference type="STRING" id="387005.A0A183HSK4"/>
    <dbReference type="WBParaSite" id="OFLC_0001046501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001046501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001046501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001046501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20441" checksum="08929B7F7F47AEBA" modified="2016-09-07" version="1">FFFFFFFSEQIYWARDIQFVFVSKGLVGLTSYLAQYHEHHHSFLQSEKLQFHSGAIVGAFAVKARGSKFDALNIEHNMVNGLLPNLDLINLMAKLADKFGLIPEVFNHGYQGSWWNFAETTSKAMLSQAFNEKEGLHSIFGPYGIQAVTIHAKNVMEGHASLTDLTRICEGALRFNFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTA0</accession>
    <name>A0A183HTA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10717</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014594">
        <property type="protein sequence ID" value="VDO70730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTA0"/>
    <dbReference type="STRING" id="387005.A0A183HTA0"/>
    <dbReference type="WBParaSite" id="OFLC_0001071201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001071201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001071201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001071201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="4986" checksum="7D91CC1339FFC390" modified="2016-09-07" version="1">MLKSLLEVLESIQAMKDGDNMQLLTARSTTLTANVRQLMSSVPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTP8</accession>
    <name>A0A183HTP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10861</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014972">
        <property type="protein sequence ID" value="VDO71923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTP8"/>
    <dbReference type="STRING" id="387005.A0A183HTP8"/>
    <dbReference type="WBParaSite" id="OFLC_0001086001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001086001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001086001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001086001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19174" checksum="E3388376770435A5" modified="2016-09-07" version="1">MEIIAVLQRAIVDRGWPRSAAHLIFAVIDCLERYTYHRRFLKIPADRTLQRILEILSNVTTQKWSDGNCLIVAAAGVCHCTTRALKWCEQYAIGYDENGQTLFKPDQFSFLEKIYFDLGDMDGVAGAFETIRSCAEPTVNDRILSLKADGNYWDALPLYRKSTSIEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTS8</accession>
    <name>A0A183HTS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10891</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015055">
        <property type="protein sequence ID" value="VDO72177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTS8"/>
    <dbReference type="STRING" id="387005.A0A183HTS8"/>
    <dbReference type="WBParaSite" id="OFLC_0001089001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001089001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001089001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001089001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16662" checksum="E445901855C9C694" modified="2016-09-07" version="1">MKNIDRLCSFLFDNVSEQLYRLNDETMDMVLRALRTTQNSISNLNSMMIQIKEGDPDVVQKFQRRGPGSRYAQWLPSFANMPERVRADSTSSRQQRRQMYDTEDYDEDTVYYRHVPLRTADDYENVYVVDEGQVETAGEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU43</accession>
    <name>A0A183HU43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015333">
        <property type="protein sequence ID" value="VDO73033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU43"/>
    <dbReference type="WBParaSite" id="OFLC_0001100501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001100501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001100501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001100501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9107" checksum="B8B19CC766017857" modified="2016-09-07" version="1">MGLRNKEKLISRSWTIDRVHGSLFVEMIFVLRTFIFFVDKDSGIILERQERSFIVSWACAFGAHGIVLMVSMMKESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUL0</accession>
    <name>A0A183HUL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DRTGG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015793">
        <property type="protein sequence ID" value="VDO74396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUL0"/>
    <dbReference type="STRING" id="387005.A0A183HUL0"/>
    <dbReference type="WBParaSite" id="OFLC_0001117201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001117201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001117201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001117201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8385" checksum="B5834CF5000E7C2F" modified="2016-09-07" version="1">MENFIIIIYLCGDLKIGAMAIMCGNMGKPYEAFLALTENMEIPLVNWDLSPILPTEETRNLLVSYQLKTCPEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUZ6</accession>
    <name>A0A183HUZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016183">
        <property type="protein sequence ID" value="VDO75504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUZ6"/>
    <dbReference type="STRING" id="387005.A0A183HUZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001130801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001130801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001130801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001130801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23823" checksum="1407A92C657BCDF0" modified="2016-09-07" version="1">MQNWNRYYYSYTVSDGIHEVQSVLTIVASEPFIKIQNSNITISTSNITSAILIPITNHNLSAITNVDAKNSDIWFHVITRNWIFISNFTKKMMKNFTQQDIDDGRILYRITAPLFDGRENVQIITASVGNLTVMKTFKILKIKLDGNERNHLEMRTLTSLVVPFSSISQIDKSILLATASDKQSNEIVFDVIRQPMHGSLILESVKGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVS6</accession>
    <name>A0A183HVS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11583</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016887">
        <property type="protein sequence ID" value="VDO77557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVS6"/>
    <dbReference type="STRING" id="387005.A0A183HVS6"/>
    <dbReference type="WBParaSite" id="OFLC_0001158801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001158801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001158801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000023">
        <property type="entry name" value="Arf-GAP with ANK repeat and PH domain-containing protein cnt-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO77557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001158801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14055" checksum="0854D1B0612236CD" modified="2016-09-07" version="1">MIYFFPGNDSCADCDAPKPDWASLNLGTLICIECSGIHRNLGSHISKVRSLDLDDWPMEYLNVMEAIGNKKANAIWEHSAPSGRKPQAGSSREEKEKWIKVKYEGKLFLPPIATNEPLGRQLLNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWB8</accession>
    <name>A0A183HWB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11779</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017491">
        <property type="protein sequence ID" value="VDO79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWB8"/>
    <dbReference type="STRING" id="387005.A0A183HWB8"/>
    <dbReference type="WBParaSite" id="OFLC_0001178001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001178001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001178001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001178001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5574" checksum="1B2220894C905A31" modified="2016-09-07" version="1">MDLNRTKSTGNVLIESSITDMSGTFGRSNSLASADVINDCCENTTKEKVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWC5</accession>
    <name>A0A183HWC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD hydrolase, family IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11782</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017499">
        <property type="protein sequence ID" value="VDO79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWC5"/>
    <dbReference type="STRING" id="387005.A0A183HWC5"/>
    <dbReference type="WBParaSite" id="OFLC_0001178701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001178701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001178701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001178701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27081" checksum="7241345FEC860E9A" modified="2016-09-07" version="1">MKYFSGKNVFIVTNNSSKALDDFAAKCRRIGFDMISDDHMLSPAKVLSHILAMEKSDLPVYLVGSTGLQKELKKRGIESFGVGPDPIENYTDVESIQQIDISRKVRAVIVSYDIHISYPKIMRAASYINQPGVRFYATNPDPKLPGPVPGVVVPGSGVNVRAVETAAGKEPIIIGKPSKTMFEYIKERYIFASLLILKWYIVPCYCGYLVLIQLNASNCNLFFVSLIKVVIFFVNHYYVIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWS4</accession>
    <name>A0A183HWS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11941</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017899">
        <property type="protein sequence ID" value="VDO80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWS4"/>
    <dbReference type="STRING" id="387005.A0A183HWS4"/>
    <dbReference type="WBParaSite" id="OFLC_0001193601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF19">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13122" checksum="9FECA68196FF87A5" modified="2016-09-07" version="1">MSDFALKLDPTERITYIGKKLGEEPCPTILKITNPTSDRQACKVKCTSNEMFRIRPPVFALKPGEEISVKLTFNAGKTIPDSGKHYFAVYYIKATDENKAPRACWSDHKGDPTGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWZ7</accession>
    <name>A0A183HWZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12009</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018073">
        <property type="protein sequence ID" value="VDO81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001200901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001200901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001200901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001200901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4385" checksum="2BD34F8DFDF90686" modified="2016-09-07" version="1">MVGDRGERERDDENLVTIFLKSTNDSYLYLPGVYVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX04</accession>
    <name>A0A183HX04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12019</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018107">
        <property type="protein sequence ID" value="VDO81182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX04"/>
    <dbReference type="STRING" id="387005.A0A183HX04"/>
    <dbReference type="WBParaSite" id="OFLC_0001201601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001201601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001201601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO81182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001201601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6589" checksum="2E9F6558E63E0557" modified="2016-09-07" version="1">MFSTTPDAFWITFLGQTIAGISQMFILSIPPRLAAVWFGSNQVSTACAIGVFGNQVCQFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX50</accession>
    <name>A0A183HX50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018215">
        <property type="protein sequence ID" value="VDO81509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX50"/>
    <dbReference type="STRING" id="387005.A0A183HX50"/>
    <dbReference type="WBParaSite" id="OFLC_0001206201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001206201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001206201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001206201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14030" checksum="B0376E7187D77409" modified="2016-09-07" version="1">MGDIISNGILPPVSRLKSSPTRRSQSPNSGGVVVSASKLCQNLIQFAQQLSMAKRRTLEDPELYQIEKHLTKSEQRNHRKMVRCKLSEMPGKLDHATVVAFKVGIWPNDDGMYFEKNYSKFHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXU4</accession>
    <name>A0A183HXU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epimerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018953">
        <property type="protein sequence ID" value="VDO83749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXU4"/>
    <dbReference type="STRING" id="387005.A0A183HXU4"/>
    <dbReference type="WBParaSite" id="OFLC_0001230701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001230701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001230701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001230701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12610" checksum="5C81A90167A73E3B" modified="2016-09-07" version="1">MKGIYEWVLDLLTFVGFYLIAAYCIGVEFYLDRIRRYNGLSRMKYLLKAIKESKFINSSNQKLVAVITGANGTIGTEITRLLLQSNFKVFLLIPKFQLVFLHKFQICCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY12</accession>
    <name>A0A183HY12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cadherin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS12374</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039832">
        <property type="protein sequence ID" value="VDP11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY12"/>
    <dbReference type="WBParaSite" id="OFLC_0001237501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001237501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001237501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25374">
        <property type="entry name" value="Cadherin_FAT4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="124"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="235"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="352"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="456"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="557"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="662"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="768"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="879"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1166"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001237501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1633" mass="183926" checksum="230D00F445A2E352" modified="2016-09-07" version="1">MKRIVCVEGTIPISNGKIEYNVNQKITDLRFSTKIKLELEVNIPEGTLVGKIALESNLSYRLNGHNQFASVDIETGEVRISAPLDRETIASNGTIILILTAEPMTIIAIRINVLDINDNSPTFPSKYMNVSIVESAVIGSRIRLQGANDPDLAENGTITNYELKNGEEFFTLIRSSNNSSGDILLLELLAKLDRETKDLFILNISAYDGGNPPRSGHCIVYVNVLDANDNPPIFRQPRYDIQLNRSILSDATLLRVEATDADVGNNGRINYRLTMNPSEYFQIDRDTGAVSIQYTALNCSEDICLQNCSGMCVLTVEAEDQGDPKLIGHTLIYVHLTDTNLYNPEINFKFYPTGSEFASISSETAVGSTVVVITANDRDDGQNVEISIIAGNDENYFRLESGKNYGILRQNRLVDKPIEQFLLKIYATDDGVPPRSLERDLKVFVRKLNDTAPVLKEKLIKVDIFETSPVGSFVAAVQASAKEDLYFSIIEDVENDELFLVGKNTGIVTLSKAWPNHTKWNYKFQIIVRKTAPSDKFSVCMIQVSIIDVNDHKPQFSLPFYEIEVSEDTPSLTVISKVYATDKDHGNNSVISYSIEDPSKEQLFMIKESSGEILLRTKLDREIKKQHKITVNAVDHGNPSQSSSVPLIINVLDINDNDPYFAQLEYHGYIIRGDPPDTHLVQLEAFDDDSPKFAQISYLFYHSVPNFLALDHKTGKIRLTSYTDLLNFERKIEITVGAKDNGGRLSRNNATVHIWLLDSMLQVPKFSTTNNWSIKINENSSPEKILATFSVQSSLENVRYRINTTDLLINELTGELRARRSFDREVEPRIGFTVYADSEWSTAMHQGTLKILDQNDNSPIFDFDGIAQFVINSRSIGIGAELFRLPCHDPDYGRNGHITYSINSSFFGIDSETGIVRLLKFPNGLNQIQFHATATDGGKQSRHSTIRVAVEINDDETTYSFPPVIALSIPENTPLGTIITNLATKNTMQRFEFRTLELPENYPIQILPSGEVFVASKIDYELMNYVSISVVAFNSDKNSFPIKHEFLLQLYIENNKFLIHENNIPGAIVGSFNGIDDDNGPNGTLFYEIMEESRKIFSIDPHTGIIRALLVLDFELIQFYNVSVIVMDEGLLKTECAIMIEVQDLNDNLPQWEQEFYHFYAPKHIEDSFIGKVLARDLDSAVNGEVEYKLKQKWMPFKINESTGDITRIGPLVPNHTYNITVIAKDKGTPPLSNVTFVFIHTDIEEDCKPNFTSYPNTNVEINGNLLGQMITQVHAVACGAEVLYSLSYDYSNYRNHSNFGLFWIDSTDGSIFLTQDPEEYIGQRIDLIIKAESTSFFNAVNFGVTVTDKRNRNSGSDRIKTVHIQENNDIGKICGRIETLGKDLQLLRQIPPGKTFRFKEQNLICDEVLDREEVNFYHLVVESRGLKSKVISIQVDDENDNSPECFGTKAILVGSESSFVSWNCLDKDDGLNGTIGYKVLRNAEIVSEINDTGFVVSSFTGDPQDFTVLAYDRNAKNEFRDDDELRRTIELHYILIPINPKLEAQIEFKKQYRLDRDIQPGTIFGTIMAKTGAVVEYFATSFRSKRNMNAVQWADIDRQTGQLLVIRKPVDHLVDIEITLLSEGFTKTITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY17</accession>
    <name>A0A183HY17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12379</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039833">
        <property type="protein sequence ID" value="VDP11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY17"/>
    <dbReference type="STRING" id="387005.A0A183HY17"/>
    <dbReference type="WBParaSite" id="OFLC_0001238001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001238001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001238001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001238001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30182" checksum="05310F3FF2CF1DA1" modified="2016-09-07" version="1">QHAAASLAGRIRAPPQVPTSRTQLGGTISSGHNNNVCEICDQNVQDRDRYLTHLQLFHKQMRGKTSADMQQGAPLACSRCRDRFWTYEGLERHLVMAHGLVTSDLLTKAQKKEDGGRCKHCGKQYAFNMLQHLVTDHQVKLCSAEIMYSCDVCAFKCSSYSKLEVHLNTVHPKNPAQNSALSNTTSSASGMLGHRSGQIIPNFGIIVLGSDENENEKVAHEFHLHFRSNAIITKSNMIKAAKPSDKDGKLQRCRVSSFKGYYMIGMLYCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYU3</accession>
    <name>A0A183HYU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-RVT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039895">
        <property type="protein sequence ID" value="VDP11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYU3"/>
    <dbReference type="WBParaSite" id="OFLC_0001265601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001265601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001265601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001265601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16577" checksum="0BE98556DB919513" modified="2016-09-07" version="1">MLPQQFQCNAPKISNPAPDPVPLKGKAQQIIAQFLMPSDPLIHAFRRKSTSLITSLSNRSGQNRWNVLYWIEVRFDSWAYHLQTWEKFVVHVLSNHFPRAITREVAGVTAQCQLFLGWGLFGYKGGVSVSRGVSKVWSTSLERAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZY1</accession>
    <name>A0A183HZY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13043</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040023">
        <property type="protein sequence ID" value="VDP12798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZY1"/>
    <dbReference type="STRING" id="387005.A0A183HZY1"/>
    <dbReference type="WBParaSite" id="OFLC_0001304401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001304401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001304401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001304401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13520" checksum="DA335F0A1C28AE6E" modified="2016-09-07" version="1">MLGTPSSSSHPQMCNSSTFRLCRFPHYRPNSLQNACPRIDQHANDLLHRLLQYEGRKRLSAADALQHSFLQCLPKAIFELSDCESVMSVPGVRLVRDSAASDRMSCQNNRSNRRQSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I035</accession>
    <name>A0A183I035_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13097</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040044">
        <property type="protein sequence ID" value="VDP12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I035"/>
    <dbReference type="STRING" id="387005.A0A183I035"/>
    <dbReference type="WBParaSite" id="OFLC_0001309801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001309801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001309801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552703" evidence="4">
        <location>
            <begin position="26"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001309801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42786" checksum="EB889447A1A08B64" modified="2016-09-07" version="1">MTIILMIRITFLLLFCHILITPVHTVVSYEPQISYFDGASYSDNCKSKLERSVTALSGLLISHQLYGSIPYNASKNCFLLIMAPSGYRIRLRVLDFNVLGNAHNCDKDTLHVFDHEKPIDPQTLRDATQEDTSPGPILGQFCGTIRNASELAVSTENALTLWWHTDADLPFHHNGEGFRLLWSAFRKSNVAPCNAQREFTCKNQECIAAELACNRYPDCKDESDLIRELQIAHKCDFLTDDPFGSLTGLTLLLISMAAVSLSACLCICACICCKCIKTPDKACTSTTIELPVERTPFCTATNIAELQQPTSPGFYSPFSSIKSPTMGKKIPQKATVNNATCFPVKVKWTSDTTVDQKHEPLNVFADQLSDDLDCKQPLAVCVIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I078</accession>
    <name>A0A183I078_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LSDAT_euk domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13140</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040061">
        <property type="protein sequence ID" value="VDP13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I078"/>
    <dbReference type="STRING" id="387005.A0A183I078"/>
    <dbReference type="WBParaSite" id="OFLC_0001314101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001314101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001314101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="947"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="10">
        <location>
            <begin position="192"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="11">
        <location>
            <begin position="515"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="9">
        <location>
            <begin position="950"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001314101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1253" mass="143338" checksum="7DB6C7745F368BEE" modified="2016-09-07" version="1">MQGEGGIDGNVGNRQMQDFASVSNADFIPDGSNDGFDSDERQRTSSVNSFCCTAPRNSISGQQFYSLTNVPNNYYAMENIKQKRSSKLFDRPELFVHVLTEKLKGPWIEQVFLKRECIKYIPTFGTNKCGCGLFLNAHSPAVISQFKATLIEDGIVPSSQSLRWSVAEHTRTAHTDAFGTLEFSGGAHAHKAHYVRLGYDSDPSDIMYLMEKIWGLEPPRLVITVHGGITNFEVQEKLGQVFREGLLKAAQTTGAWIITAGIDAGVVRHVATALDEAGISARMRSKVVTIGIAPWGLLKRHEKLIGKDIVVSYDPHSFSSKSKYATLNDRHSYFLLVDNGTSGRYGADIILRKRFEEFIARKQTIGLGTRHVPVICAVLEGGTCTIRAVLQYLTNQPPVPVIVCDGSGRASDLIAFAHRHVLENDNLPMEIREQLLNLIASVFRYSSTPVEQILDEILCCAKHRDLLTVFRLNENRKQDVDHAILSAILKGQNLSAADQLALTLVWNRVDIARSDIFVANQNWNPHLLYDAMMEALALDRVDFVKLLLENGVSMKKFLTISRLEQLYNMEQDSILPLINDSMSIADSRITLPKIGVVIERLMGNAYKCSYTSRKFKNKYEKSKKKALISRIPSFRSLCATYSKTKHISEEAKSNTRKRLRKEIKEGDDFQFPFNDLMLWAVLSRRQEMARCMWTYGEEGMAKALAAIRLYKSMSKEAADEYIEVEVSNELREFAEEFKRESLSLLNHCYLQDDAGTLRLLTAELPNWGHHTCLSLAVIANNRRFLAHPCCQILLADLWHGGLGIKSYSNLKVILALAFPPSILLLDVKARISNRRMDFLTQHSFVFEGNESNNEKEDDDRSQNSASSSFYVSEHLKIRRKTKYKTTAFSQRMTNFFETANLIDETLRVRSGIREPRKSVGANLQEMTQETSWTTKFSIFYSAPITTFWIWLASYFIFLGVYTYVILIEFPVKPTEVEWFLFAYVVALVMEHFRKLLVQEASTICEKIRVYFDRCWNYLTWLAIITFFIGFAFRCNQPTRHSYGRVILSCNIVFWYIKLLDFMGVHPRLGPYIQMTGKMIVNMMYILALLLVTLMSFGISRQAITNPHEKWQWVLIRNIFYKPYFMLYGEVYAGEIDICGDEGINCVPGGWIPPILMTIFLLVANILLINMLIAIFNNIFNETNAIAQQVWLFQRYEQVMEYENTPFFPPPFTPISHLLILFKYFWKVRKILNLTIQLLKKNSHSYKREFDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2R9</accession>
    <name>A0A183I2R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14031</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040548">
        <property type="protein sequence ID" value="VDP15318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2R9"/>
    <dbReference type="STRING" id="387005.A0A183I2R9"/>
    <dbReference type="WBParaSite" id="OFLC_0001403901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001403901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001403901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001403901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22781" checksum="37879BF4B3B2DC73" modified="2016-09-07" version="1">MKVTENQNLILFSIIEHPVYLGFGTVLEPQLSYRLLSHYMPLGKIGGKPAWLNPVNLPANNSLLCRICEKPMVFLIQVYATSPDDQDYSFHRTLFFFICRDSQCSRSNDASNVRAFRCTLSRFNDFYASEQPIDPDLEGDVPDPFWKQTYPHLCQICGCSATKKCARCESTWCFFLGFFPLIEKMSPRILSIHFYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I307</accession>
    <name>A0A183I307_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF3338 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14119</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040608">
        <property type="protein sequence ID" value="VDP15550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I307"/>
    <dbReference type="STRING" id="387005.A0A183I307"/>
    <dbReference type="WBParaSite" id="OFLC_0001412701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001412701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001412701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF2">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytohesin Ubiquitin Protein Inducing" evidence="6">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP15550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001412701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="687" mass="76629" checksum="867B4A8ADF117267" modified="2016-09-07" version="1">MPSAKVSDGSFVSLSSLNDVQNREKIQEEKQKEIELYRQLKKRKNELEEKLLAKLDELREEITGELPKEIYKTLMPGEEEPKVKRRVGTAFSLSEDVFKRPVDSNDRISMLEADVELHRKIVAAAERLAKDKTTNKSVRKKRQKDLIAATQKLRGLEFGLTQLRLSASKPDVSLSVHNVSGNKGPWRNCSDYQIESTSLGTRNDSNSLITKSCPATPRGSFPDLLTSADNERSEVDDDDDDDGKRRASTECVQRYPSTSACPSIPSAYHITNNNTYLTTVTESGLSLGNPSFDSRISKRSTAPLLHPTCYYLPEREISWEKLKNHNAENHLIPVYENVGYKSCVSYKSSYREMNFPTLNDHTNFKDRVQRAFSDHDLPEQGPVTTKNSDKYESRIDYAVVESNGSSRNIADYGTALKQPSWKYRCGQENSRDHCIIGAGTGSSAAGRQLIIQQQQQNDEIPSSSCLGPKLVNSSPETYQQTSSSCCNSPPVAGLLSTDGTTPLRYTLLPTSRSYNEGFTTASLDRRAMKERQSSSSSMGYHHLRPTQLAVSDMIREICTEQPVTRHSHLRTSRFTTTFPVSGPASLEKSKPLTSADILRYQQRSPLQQHNSPEHSVTSPGNIVQITGSSSNLRPPPPAYPFAIRNGIFGVRSPLGKVITAPTDRRMDTLKNYYKDKANGSKKNATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3V4</accession>
    <name>A0A183I3V4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040837">
        <property type="protein sequence ID" value="VDP16957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3V4"/>
    <dbReference type="STRING" id="387005.A0A183I3V4"/>
    <dbReference type="WBParaSite" id="OFLC_0001442401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001442401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001442401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001442401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7590" checksum="0D28DA355185C086" modified="2016-09-07" version="1">MTTLSLTWTNSFYSIAFISPIYRKNFIDGWEREGVAIAVFRNDELVVDLQGGYYMQAHSIFGHLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4R2</accession>
    <name>A0A183I4R2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14724</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01041128">
        <property type="protein sequence ID" value="VDP18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4R2"/>
    <dbReference type="WBParaSite" id="OFLC_0001473501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001473501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001473501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF80">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001473501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41426" checksum="7527F1A9DD6C1B5E" modified="2016-09-07" version="1">MASHKKLPKAYVSRMDKPSLRVPVVLQEARVMPKQPRKHYLAVCLQPIFLLADWTLLVQFFEIWIAQGVTKFCVYVQSMTPEVDALLRVYEHSKDVEVERINWAPLPTGEVAAHENDPNLRIYRTEVTTSINDCVLRSRGHAKYVISSDLDEILVTYKETSLLKLLVSLQAKFKNSAAFVIRSSFALFENHWANISKPTDIDFNSFANISLENYVWPAGFRSKAIMIPEYVYSAHVHQVLQPEPGKIIKIIPPETALVFHLRRVMRDKLWSSNTTVKTNALARFIDPCNKSWKNRLKIIRQVPETKILHRSEWPQRGSQIEMTHEKKKEKKLFKCRFCYFYKMVPFVQISRFFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4R4</accession>
    <name>A0A183I4R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CYTOSOL_AP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14725</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041129">
        <property type="protein sequence ID" value="VDP18433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4R4"/>
    <dbReference type="STRING" id="387005.A0A183I4R4"/>
    <dbReference type="WBParaSite" id="OFLC_0001473701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001473701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001473701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP18433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001473701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47452" checksum="063FA6A49D066C5E" modified="2016-09-07" version="1">MSSSIESYLSAEISAAKSITENIYDGIVCIAHSLSETGKYEVLKPLLPSLLVYSQIHKDIENTTTLILVDGDILPSRKLIFAGTGPVNRDYDDVRRFGIAARNGMKLALKSGMKAPLILTLPHEKYPQAELVSALGAMHELYVPLNVREEEKKTKVDTVGFYTLNYDQKLSFGFLKYPKRGGEKAFTVCRDIGDSDPQRMSPSNVAEYITNAFNGTNITTHITSDVTEIEREFPLMAAVNRAANNVKNHQAHLIWLEYNPEGPCDETIMLVGKGVTIDTGGADLKTNGAMFGMCRDKYGAAVVAGIFKALEILKPRNIKKPRLFTLATLTGHCILSYGYMAAAMDNGPARKNHTAETIRGWGDAFGQPVEISRLHWEDFEFHEAESEAADIRQSNTLPSVRTLRGHQGPAAFLLKGSRLDEHGCDSQTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6G4</accession>
    <name>A0A183I6G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA_lid_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15326</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041960">
        <property type="protein sequence ID" value="VDP21347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6G4"/>
    <dbReference type="STRING" id="387005.A0A183I6G4"/>
    <dbReference type="WBParaSite" id="OFLC_0001533701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001533701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001533701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000215">
        <property type="entry name" value="BMA-SPAS-1, isoform e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="3">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP21347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001533701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17695" checksum="B225CB88E4575AEF" modified="2016-09-07" version="1">MKTEFLIQMDGMLSSKDDRLLVIGATNRPDELDSAVLRRFPKRILIDIPNAAARLKLIMSLLEKTKTAFDLSVAQKEILAERTNGYSNSDLVALCREAAMVPIRDLSRKDIKNLASTEIRPITMRDFEVAMKAIKPATNDRMLQKLRKYAATTGQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6I8</accession>
    <name>A0A183I6I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF630 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041998">
        <property type="protein sequence ID" value="VDP21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6I8"/>
    <dbReference type="STRING" id="387005.A0A183I6I8"/>
    <dbReference type="WBParaSite" id="OFLC_0001536101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001536101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001536101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001536101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27615" checksum="C954F4FF90A9E452" modified="2016-09-07" version="1">QKLINTEQVTVLDLRCANLVIAARLYSHAHQYMEHMVDNYLCLAKERFEQSKNAPETISRQRARLSHSFSISSLLVTCINKQCQKSASQSTNFLCSDCFEYQKQLMASFGCSQPGHLRSLRSCLSTTLRDPSDVSPRRDDSIKSNTMPFITVSSKTASHIDGKGHRNARDVLGHVSNPLSVSIAADGFMQALQSHVPSSKHYCEHMDAGCEEVVHTVAVHYTHAPSENITTKVASVEGANGVTHYYISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6W3</accession>
    <name>A0A183I6W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15475</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042208">
        <property type="protein sequence ID" value="VDP22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6W3"/>
    <dbReference type="STRING" id="387005.A0A183I6W3"/>
    <dbReference type="WBParaSite" id="OFLC_0001548601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001548601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001548601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005514">
        <property type="entry name" value="DUF316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03761">
        <property type="entry name" value="DUF316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001548601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11289" checksum="BA9B46888DAE6E16" modified="2016-09-07" version="1">MMSRLNYGSAKILGVAKHRDFIRAGPIYKPKNATHHHGICAGDSGAGLQGYFKHRAFLLGIHSFSSMNCYDGTPFTMTDVRRYAKLICHLTGICYHLSSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I729</accession>
    <name>A0A183I729_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042331">
        <property type="protein sequence ID" value="VDP22452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I729"/>
    <dbReference type="WBParaSite" id="OFLC_0001555401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001555401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001555401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001555401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11158" checksum="0D5D81A921360582" modified="2016-09-07" version="1">FKKSYAQDAISFPGIGELHAKYGGAFERNWPEMNSKISANEEEMPKVDLMHRASSPSFPKQMERFREFLEHQHDLMRDLKMKPARAPLPRAPTISGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I780</accession>
    <name>A0A183I780_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15592</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042423">
        <property type="protein sequence ID" value="VDP22743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I780"/>
    <dbReference type="STRING" id="387005.A0A183I780"/>
    <dbReference type="WBParaSite" id="OFLC_0001560501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001560501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001560501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001560501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25897" checksum="F9E85F6DD5E5B225" modified="2016-09-07" version="1">MTRKQSDCDTFQKLDASRIRNVCIIAHVDHGKTCLADCLISSNGLISTRMAGKLRYMDNREDEQIRGITMKASAIALVYDNNIINLIDSPGHVDFSDEVSSVLLLSDIAFLVIDVVEGLCSQTEFFLRQAIQLNLEIILVFNKIDRLAVEIKQTPAEAFAHIRCLLEQVNSCISQIISGALVEHEDWHSVECAEKGLYFSPENDNVIFASALHGYGFSLSDFGRIWSKKIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I889</accession>
    <name>A0A183I889_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Raptor_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15951</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043345">
        <property type="protein sequence ID" value="VDP25268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I889"/>
    <dbReference type="STRING" id="387005.A0A183I889"/>
    <dbReference type="WBParaSite" id="OFLC_0001596401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001596401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001596401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP25268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001596401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22351" checksum="455935E5D8226910" modified="2016-09-07" version="1">DANVEHTDPPLPTWFQELRHVEKIVGIKEEIVDRDLRKYSKERMRTVSVALVLCLNIGVDPPDVHKPNPCARKECWIDPLGMNPQKAVIKIASALQKSYERWQPRARYKAANDPTVDDVRRLCQSLRRNAKEERILFHYNGHGVPRPTENGEVWVFNKNFTQYIPLSIFDLQSWMGHPAVYVWDCHCAGLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8Q6</accession>
    <name>A0A183I8Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01044194">
        <property type="protein sequence ID" value="VDP27525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8Q6"/>
    <dbReference type="STRING" id="387005.A0A183I8Q6"/>
    <dbReference type="WBParaSite" id="OFLC_0001613101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001613101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001613101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP27525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001613101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="46" mass="5457" checksum="EAE70108C48F5785" modified="2016-09-07" version="1">MYLTPGDRATLEKYRKGQTTLIGTEIEIDHDILLYTLFLNFARRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VEX6</accession>
    <name>A0A3P7VEX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004119">
        <property type="protein sequence ID" value="VDO41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HC18"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF87">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN C34C12.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="380" mass="44788" checksum="E77936F6B6171E50" modified="2026-01-28" version="1">MPAKFQSPSPASIHECALIEQLRNKLTDELPDGIPNDLNTDLNLLRWIRGFDANFDKITKNFYTYVESRRAAGFDVSDLPEKFFDLPHIKRFLPYIAASRLNDRLWLDERNAFLFVERAWCQPKELILRREKKQNATKGLVQFIVFFDAATLNLIDYLNPMSAQIKFWQVRSELWQNWYPEMVQKIYLVNPPRFISTLWKVVGIFLKKENLELIEIIGNQKDLQNDLPAWFIPREFAGEFVNDVQPYDETGVSIRRKIVPDDYIKSHDLCQSKGIDQPKPRQKKEELQEISAGAVFVESIILPDDHTKLFWNFTCSTDVEFTIYNKKKRFLYPRLHLFTLKVPEEGILENLTPNSEYFFEFRVNTGYFNARLDYSIYSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VSU8</accession>
    <name>A0A3P7VSU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007896">
        <property type="protein sequence ID" value="VDO51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="116" mass="12752" checksum="E773649F24F79877" modified="2026-01-28" version="1">MDSAGQSFDLMIMDSWRLGVRGQLSSQERVVVSSFALSFPSNFPDNLSMASSLVTAENPPPPPFPFPYYSTNQMNSTNGHSNNNSTFTCTAPQMSCQQPSLPFNSNICRKNVFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z339</accession>
    <name>A0A3P7Z339_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005629">
        <property type="protein sequence ID" value="VDO45452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856367at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="136" mass="15628" checksum="4E8EFFDDB625B1D4" modified="2026-01-28" version="1">MRGSRMPYARRFNSDGLEVSTSLELLSPDKTSIQHDYKPVDSVFAYLSYLRATSCYCVLHDDRLLKIGIANFQKFYIKYLYFRLIAVLMVSLYTSGLLAVLYMLIMISKFDKELENCTTTKIAITDAKVTIVDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BC07</accession>
    <name>A0A3P8BC07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040448">
        <property type="protein sequence ID" value="VDP14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2C2"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="573" mass="64603" checksum="0FED8ACBD308DFB9" modified="2026-01-28" version="1">MEVQRELSNGKQVIPITDLGVDQLTYFQRQLDQEITFLTESLKELKIFESKFIASEESVLNVAKIPSDKEILVPLTESASFMYIPAKIADPTNHLIEIGTGYFVEMSTEKAADYFRRKQTFLKKQMEVIEEALPEKYRARNTIVDNLQKKINEYCSQGSSVFWMRIEPLSNCEKAFFLNSFKQNVRTDGRKCDEFREVKVIVGSELGSCLAMLGETKVSAQVSCSLVEPSTTRGNMGVVEVQVDMSPMASPDYEDGRLGSKGLELMRILELLYRNCGVIDLESLCLRTFKQVWQIRIDVHVLASDGSLVDCACIASLTALAHFRRPDVSVLPDSIIIASFFIILYELALFHKTSRHGNDEKIPISLNIYHMPICVTFGITSDGQNIIDPTDKEEQCLRGSLIVATNKRHEICALHQSGNFLLNEQLIVQCVDRAIQRAIDVTELIYSVIADDNLKRSNRQQVNGFSELITLNVLTSHQCEPNELIAPAVKIDALGNIPNVEEDITVSDNQMQIGSDSRVVKQKNDEDVELMEQVQSITSLEESKNQENKNPRDLEEVDELLQSIEEEFGSPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C259</accession>
    <name>A0A3P8C259_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039989">
        <property type="protein sequence ID" value="VDP12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="204" mass="23546" checksum="472C23403E5F8AA7" modified="2026-01-28" version="1">MCHLMLAWFTRGKRRVKHRNTKKEKMKKRYREEDEKDAEEETSFATNENTARDREFGVEEREKAVPCVLDYLSDTYPQCAKWGSGQEKSATLWISKNSLLSLALPYMLIGLPESHCGDILIWNGRSDKYSSKTGRERKREHGNDGGAEVQLMENNKFQESKRRAIESASIGMNERPFADVLRACRSLIACYVLVLLLFEICEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C2T0</accession>
    <name>A0A3P8C2T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040022">
        <property type="protein sequence ID" value="VDP12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZX9"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="147" mass="16839" checksum="B1E9DA30ECF94C13" modified="2026-01-28" version="1">MSSFRSYVWDPGLIIMQIVCLQATFYTTQCILSVLISTGGDYPSLEQVFTTEASLHGAITQLLSVAVCSLIMSKVVERSKQCLDFACTLHFWHFIIVTLYYKSISTHVFWWLLQLLSIASCTLLGEYFCLQIEFRDIHLSTNSRYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F3X0</accession>
    <name>A0A3P8F3X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040342">
        <property type="protein sequence ID" value="VDP14426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1T3"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013706">
        <property type="entry name" value="PDE1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08499">
        <property type="entry name" value="PDEase_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="508" mass="57908" checksum="A9752EE9A9CABEB4" modified="2026-01-28" version="1">MLGDSYGSHHLIIRKHACRLRYILHQLNSAQLSMDDLKKNLEYAVLLLETEYIDETRRICDEEDDLADVKLEAVSTEVREWLAATFTKQSVLSKREKPKLKSVANAILTGIFFDKMFRKTQVLLISTPPEIAAVMKNLNSWSFDCFKLNEVSEGHALKYVGLELFIQYRFFDRYKIPVQTLENYIAALEVGYSKHNNPYHNIVHAADVTVSSHFMLSQTGFATSLSDLDLLAVIFGAMIHDYQHTGHTNNFHIQTGSHFALLYNDRNVLENHHVSASFRLMKEEDKNILKRLSREEFRELRNLLIEIVLATDMSSHFAQIKTMKCMLSSPEGIDKIKAICLIVHACDISHASKPWELHSRWTEGVLEEFFRQGDLEASMGLPYSPLCDRNTVHVADSQIGFIDFIVEPTMVICQEMLTNIIEPLIPLQSSNTFLPSENPDSPSASADITQTSETENTSNSETNSSIRSIPLNQAGKLELPTPWIGFMQENKVRWREQIAKEEAANLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F572</accession>
    <name>A0A3P8F572_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041285">
        <property type="protein sequence ID" value="VDP19249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I545"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="192" mass="22517" checksum="34B4D5518A23C162" modified="2026-01-28" version="1">MPRVKNVMSKVYKSPRRPFEKERLDQELKLIGEFGLRNKREVWRVKYTLAKIRKAARTLLTLEEKDPRRLFEGNALLRRLVRIGVLSEDRMKLDYVLGLRVEDFLERRLQTQVFKLGLAKSIHHARVLIRQKHIRVRRQIVNVPSFIVRLDSQKHIDFSLKSSFGGGRAGRVKRRNAKKGFSGEGEESDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXT6</accession>
    <name>A0A183GXT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS46</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000011">
        <property type="protein sequence ID" value="VDO24327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXT6"/>
    <dbReference type="STRING" id="387005.A0A183GXT6"/>
    <dbReference type="WBParaSite" id="OFLC_0000004501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000004501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000004501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000004501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="23023" checksum="543475CA84523354" modified="2016-09-07" version="1">MGIAKHNKDSIYNDSVIGKSAELIQSGRDPYMDYYGRKKSPVYRNEKRLRSNYLNDLGRQQYRNRESSSYLCEEPERNCANRHGYRKSNCNRFWKSFRRLFKAKGERDRRHCYRSWEEELADERYPSVREAISVSSITSVLTPAETKAMQTFPPHPPAEKEKTEEKEKSMEKVIKSTPMEQMPQKMSETVCFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZQ6</accession>
    <name>A0A183GZQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000266">
        <property type="protein sequence ID" value="VDO26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000071501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000071501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000071501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000071501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10316" checksum="B40E7E945B9103BB" modified="2016-09-07" version="1">MDSAGMVSANFFFCIQTPIKSCGTISGMEKFMKAPSLPLNHPYVLTFIHLLMCVLYALVIYKAMNYFGVDRFVIKHWTQWSKKIHPNLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZU0</accession>
    <name>A0A183GZU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANAPC4_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS750</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000285">
        <property type="protein sequence ID" value="VDO26926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZU0"/>
    <dbReference type="STRING" id="387005.A0A183GZU0"/>
    <dbReference type="WBParaSite" id="OFLC_0000074901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000074901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000074901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO26926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000074901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44749" checksum="35606C0DA7E52448" modified="2016-09-07" version="1">MADAFIDVADFQFRALHRVRIFNEPDGKLYDSICPSWITVSSRYGIIVCASGYNKLISLRSSDVHRLNTSKTDINVEVTDIQTKITNLQVEQPAALVALSCNCSGRVLSVSMRTASGAFVYLYDMCAFAVDYIEQRGPVYSLRLSADPNAQPCALKWNPQQDAIFAVATSDGLLSCYSFNIEAIQSNKISRQKWSPKGKQLIVGDISGYVKQYKPEMILVRVTPPPTDVVSLKDENALRCVGISWLATTDFLIAYSPKTGRKVNISKLCVKKDAPPQWTHFDDINFCGDKSTFDQRIEFTQLMGWKLVLCSSSRSSEIAVLGKIDSEWKVWTLDDNGRIEMPLDAKHCETYPVGISVDVSSILPVKIGVLFTLIVLAQTNDHSFFYRKMNSVHKASFCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H048</accession>
    <name>A0A183H048_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS858</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000344">
        <property type="protein sequence ID" value="VDO27339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H048"/>
    <dbReference type="STRING" id="387005.A0A183H048"/>
    <dbReference type="WBParaSite" id="OFLC_0000085701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000085701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000085701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF26">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="111"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000085701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="733" mass="81841" checksum="9E99ED033790C5CC" modified="2016-09-07" version="1">MDDTHQLANFGHRPLGDNGCILLTDDNHIFSRENGYDTNNDNSDKDGDNGSNHNLFLEPKTPVRNTSLHTSESNGSMIIHNEEIILKMYDNSMQNTLLYHLNTFRRNRELCDVVLFVHEKEILAHKIVLAACSPALMDMFVRRENGDQSSKRMNTVMSTGSTISPPLTTVPASPIVPQPFSYYEFAEADYDCFEAIVNYAYSSHLEISNKKVGELYKTAYALQVTQVAKACARYLIENLNVMDCIGIRRQANINDDVLVEQVDDFIAKNFAQIVDESPEFTHLPLIKVRLILSIDDTKRLCCGEDIALRVVQYFQSLPHTSDRIEQWIEQLVEKTHMLYMETDDKLQDCLEMNDHSSVGASDIIQDYKRTGGYLPRTYSGRCSVLEMQTPAHHITGATAVHLNSGRLSNTKLSSADSNSSLSSSTEHDDESYKLIAVQQTAEDFWIAVAVFYRCLIALSIQLSEAENVIKPRMTSQNAEPSSTFGTVQQRELGEETVVGLISSENDSRIPLPQMESPRCSVGGAFIDGKIIVCGEHYSISGYDRGKCLDSVEEYNLLEGSWRRLADMAQCRGRFDTAVIGSKVYAVAGSSGSVDLKTVECYDSKIDKWSPVKSLHHGRSHNGMKIKLLILCCAALDGLIYCMGGCCEQNVLSECERYNPELDEWTSIAPLRTARFQAGCTSWHDFVIVCGGCDGWKCLDSVDAYYPKTGKWQRLAPLKTARRGSAVAVVKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0C1</accession>
    <name>A0A183H0C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS931</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKLE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000381">
        <property type="protein sequence ID" value="VDO27616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0C1"/>
    <dbReference type="STRING" id="387005.A0A183H0C1"/>
    <dbReference type="WBParaSite" id="OFLC_0000093001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000093001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000093001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANKLE2 third alpha/beta" evidence="5">
        <location>
            <begin position="265"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO27616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000093001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="616" mass="69749" checksum="3A6016A94DF62263" modified="2016-09-07" version="1">MEQSKQPEEYYAVHIPSPEGASEGAVFATLREASSFANSPESARFKRFQSPEDAKNYAENGDMFCKSPEISIKSEPTGEPGSSFPSVSRIMFNRLKKAIESKDYELFLDMALQNPRYLINIGSDTPTIVVEGFRYNAMHLAAKVGNLHVAKYILHLICDSEALLTLYGTSEDDVKMRSRILLDCYLNMPDKGSHDTPLHFASKFGHCPLVELFLSYNICQKNPINKKEVRKFRMGFTPAQICCTRYVGCDKEDLHAAMMPLFLSFFTALYRPTDNYYSITIQLLEEVPTNTLPNDTPGSPTCMSALEVCELAAYAGPFADKALAQKFYETWKIEEKDCRRSHPRKGAERIGRRLASEYKITWMERWNFCNKLLDFQSYSGLEELNRYLVQIRLNPSIPSVRTVNFDDDNDSSIFSDASDTVFVEDQKNGIDAAETDDSHSSSLNEITNKQTSLLLYIKKSKILKHFKRTQLNFRLASLHLDPSSSSSSDVFLDSGNLASKNNALSIKNSSDSGSLESIVVASDVQYEQANSNDERSDSIDFDYYTPPSSPEPVYIYEGIPSKDDEELIIALSLVDPQLIQRFGAIAEYMRHVLNVPEKERSQWPFTDSPRAKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H182</accession>
    <name>A0A183H182_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1242</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000554">
        <property type="protein sequence ID" value="VDO28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H182"/>
    <dbReference type="STRING" id="387005.A0A183H182"/>
    <dbReference type="WBParaSite" id="OFLC_0000124101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000124101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000124101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000124101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27973" checksum="4C83AD5089D76ABE" modified="2016-09-07" version="1">MPSVSTINTDFYDACQLNLSDHTANLNINDKDSLIGMGSGSAMSRQMPPNVNCLCNGRSLISQFTHHHNHHQQQQQQNDAWNSERCSPYGQYPMQAYVQQRPVPHPASESMSSSPNSETDVEYGQQSSLTLPGLTGPIQLWQFLLELLMTESANSCIAWTGDGWEFKLNDPDEVARKWGIRKNKPKMNYEKLSRGLRYYYDKNIIHKTPGKRYVYRFVCDLTSVLQMSAEQIRRKVEVKHELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1B8</accession>
    <name>A0A183H1B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1278</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000577">
        <property type="protein sequence ID" value="VDO28948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1B8"/>
    <dbReference type="WBParaSite" id="OFLC_0000127701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000127701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000127701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000127701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20823" checksum="FFBFBAFD8104A508" modified="2016-09-07" version="1">MKEMKEKVESLKKAMKEMQEAIGANSKIEAYQKAMNLNLVPRGPSTSTSSQAKPPTVINQSRIFLLSQNDNTGSNWSGWTDWQRCFCGKQIRTRICHYETSFLVNGCKGKSYESRPCNERDHCPTTTPLSTKISSASTTVKAKFRKSSLHQPLSIATAQKTNEMQINYFNDSNTNDDIDPAISDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H237</accession>
    <name>A0A183H237_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1547</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000747">
        <property type="protein sequence ID" value="VDO29938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H237"/>
    <dbReference type="STRING" id="387005.A0A183H237"/>
    <dbReference type="WBParaSite" id="OFLC_0000154601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000154601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000154601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000154601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9903" checksum="9109D3FA644A4EB6" modified="2016-09-07" version="1">MYAKIETKRLVFIRLNQTKLYSKENIHLRDTVDNTTKVGKLTVLSSLYAGSPSHMHEYTFKVQYHMFATTGVRPIHYIHMQFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2E4</accession>
    <name>A0A183H2E4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1654</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000824">
        <property type="protein sequence ID" value="VDO30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2E4"/>
    <dbReference type="STRING" id="387005.A0A183H2E4"/>
    <dbReference type="WBParaSite" id="OFLC_0000165301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000165301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000165301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF43">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO30322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000165301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39433" checksum="FE7F94B31970F74C" modified="2016-09-07" version="1">MYCAQFNPRQVHIISVCNGRDGLSLHDIRKLDSPCFQFDQLTRARVNLNISSVMYGQWSDDGEAIFATRSRTSPILYDLNGGGSVEFNDQNYLNSCTVKSCSFISRDLVMTGSDDWNIYIWKVPEDRETVGQSVDKAYRVLEGHRSIVNHARYSPSNRLLFSSGVEKIIKCHKLCLVLRTIFSVIQLWSEWDVNGFYFEPKRRNMIPSTDYADPGNDDSIDEDVNMLAFFDLLTTSGIDEEGPEDDGFHNLSDNDAGNDRMIIAARLIRDTHNRDDEDGIGQEDDDENSDAGLQHIEERIILARIRRRAEEPLYVVPSPEMSEPELLPEEESSGNDSSQRITNADTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2G7</accession>
    <name>A0A183H2G7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone-lysine N-methyltransferase Suv4-20</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">SET domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">OFLC_LOCUS1677</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60348"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.362"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000838">
        <property type="protein sequence ID" value="VDO30401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2G7"/>
    <dbReference type="STRING" id="387005.A0A183H2G7"/>
    <dbReference type="WBParaSite" id="OFLC_0000167601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000167601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000167601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDO30401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000167601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="637" mass="72912" checksum="D695798B69342E2D" modified="2016-09-07" version="1">MNLNPELLRLPDRSSGQHNMTIRELCDNDDMATSVIVDPILGFRTHKMNLHYRPPQYEEQIKLKSILKKYKEDQNLCAAVQNIFHVNVVMRFLKRRTLKQQLAFRDHMFSNDSGFTVQVCHRYKTENRLGGMLVATKSWQKGDIIGSLVGVIGDLSHEEESQLLRKDVNDFSVMYSTRKQRAQLWLGPAAYINHDCHPNCKFVPNSYAAVVQVLRDIALGEEITAYYGDNFFGDNNSRCECLTCERACRGFFTSLDVTAAASLEKNNGESKQYGNNYKFRITDSRLCRYMPQSNQRKTTMTLRRHTVAALRHVPHRFSSERLQTEGPLNRLKRKTDKVKNGYCVARNHQRLNHAIKTSSSSSYSAMPNVQTWVNSTPYMIMNSTKEDNSKTRKHSQENNVNISNNLVPTRKSHVYQTIKQRKSAKNNETTQLNHARKLKDRTSIQLSNEEPHTSQNGLQILAAVAATMSFIDGSHVISLSEDSLNCIDAVDDHAVKNKQYSDDDMEFRSASNYYNGCNLSLNRSAPEIVENHSSCESDSLEEVVNCSKSYRSGNHDVLSTVFSRNGYYDEDRDNCDDISETGLDRDMNYRKVEKPVSQVQYDNVSGTNFNNMHRRPRTKVHPYYKIAFHSLLTPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3D4</accession>
    <name>A0A183H3D4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1992</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001068">
        <property type="protein sequence ID" value="VDO31509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3D4"/>
    <dbReference type="STRING" id="387005.A0A183H3D4"/>
    <dbReference type="WBParaSite" id="OFLC_0000199301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000199301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000199301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000199301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29236" checksum="5ACBF9F57DAEDCB2" modified="2016-09-07" version="1">MNAVLQGLFHIKAFEDLLNVVPESSQGTILSALKALRKNYQKATNAKKRYLLENVFKFLDDERFEITEQEAAYSIFDFHIQIMIFHELICREVAEKQAEEEKRDAQEFLTIMLDKIDSELESFENNTIAERNHLFESVTALSSIFGFELKHEITCNKCSSKQVMYEKGVFLPIQIVHKLNNDSPSLQMLLGNYLKNEIVEHICPRCNEKHATMSHQFRTLSKYYTYNLNFLPILNASRHSPINLESYCGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3F6</accession>
    <name>A0A183H3F6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="7">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2016</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01001081">
        <property type="protein sequence ID" value="VDO31585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3F6"/>
    <dbReference type="STRING" id="387005.A0A183H3F6"/>
    <dbReference type="WBParaSite" id="OFLC_0000201501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000201501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000201501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO31585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000201501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19233" checksum="F62DE682B65557DA" modified="2016-09-07" version="1">MTIRLLVSMIDSIIVHFNGRVPYEINGRSRAMLAIYPSNGTHYVKHIDNPMKDGRCITAIYYCNQNWNAEKDGGCFRLFPETSDVPLDIEPRADRLLLMWSDRRNPHEVRPVYRDRYAVTVWYFDTNEKLAAMAKKCKRNGTDEKIENKEQLQQPILLNNEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3K4</accession>
    <name>A0A183H3K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS2064</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001113">
        <property type="protein sequence ID" value="VDO31746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3K4"/>
    <dbReference type="STRING" id="387005.A0A183H3K4"/>
    <dbReference type="WBParaSite" id="OFLC_0000206301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000206301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000206301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000025">
        <property type="entry name" value="ATP-dependent metallopeptidase Hfl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="344"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO31746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000206301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="663" mass="73235" checksum="FC7B4B6729DC89EB" modified="2016-09-07" version="1">MIRLERRLIDTLSRLRCKIHKRGYAQLRASLTNTSLSKGTIVPEVSIISLLQTGSQTWEWNVILKSLQYLCFARKKLIDDLIDQFEKNLKAARKISQEINDKHASESSQKGNSGNQPSENPNRGKRPPGLPDIPMPPLSAILAAIAAFAVLFLMANKGKEISWKEFYAEYLAKGLIDRLIVHRNWVEVKVREDANVGITPYFYIGSVETFERSLAAAQQHLGVDPENHVTVIYNPIDTSSVISSLIPVAILFLLAWPIIRMFFSSRRSSGKDVAGSRGGASPFGGGGPFNMFGFGQSTARLINKNDIDVKFKDVAGCEEAKIEIMEFVNFLKNPEQYKKLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDMFSMARKNAPCILFIDEIDAVGRKRGEGRFGGHSEQENTLNQLLVEMDGFSTEESSVIVIAATNRPDILDAALLRPGRFDRQIYIPVPDIKGRASIFRVHLAKLKTNLDKMELSRKLAALTPGFSGADVANVCNEAALVAARDAGNEIIMKNFEQAIERVVAGMEKKSQVLQPEEKKIVAFHEAGHAITGWFLKHADPLLKVSIIPRGKGLGYAQYLPKEQYLYSTEQLLDRMCMMLGGRVSEEIFFGRVTTGAQDDLQKITEMAYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4G2</accession>
    <name>A0A183H4G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Netrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2372</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001351">
        <property type="protein sequence ID" value="VDO32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4G2"/>
    <dbReference type="STRING" id="387005.A0A183H4G2"/>
    <dbReference type="WBParaSite" id="OFLC_0000237101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000237101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000237101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000048">
        <property type="entry name" value="Netrin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="10">
        <location>
            <begin position="98"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000237101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27665" checksum="F1013C8E8046351B" modified="2016-09-07" version="1">MELYRLSGNKSGGVCINCKHNTAGRNCHYCKPGYFRDLTKSITHRRACKACNCHPVGSLSRSCNQSNGQCICKDGVTGLTCNQCSKGYQQSRSPLHPCIRRDEEERGVGDGSAVEKMVPQSISVSGSTTIHDAVEVQVTKRESVDGWSKYRLIVLAIYKRDAGIRLRRGEQSLWISGKRTACKCPKIRVGKKYLILGQNDTNDISRPGIVFGTRTVVLEWNDEDLEKIMRFFKKEKKGQCPARRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6A2</accession>
    <name>A0A183H6A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3013</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001889">
        <property type="protein sequence ID" value="VDO34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6A2"/>
    <dbReference type="STRING" id="387005.A0A183H6A2"/>
    <dbReference type="WBParaSite" id="OFLC_0000301201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000301201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000301201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042627">
        <property type="entry name" value="FBXW2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000301201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26172" checksum="92E6356E065BC175" modified="2016-09-07" version="1">MRLGDYDYLQNSHSEASHSYITPLRITKLAQCESLLQKYNECEQIGTYNDYRDNPNLTNYHLDSPESPNIDDSDEEKEREKQEEQKEKDYEKSQEAEHQINENLLIWIKQFKMLSSSDQMDALTDLVNECSLDHIRHLRSVIEPFFQKDFIKELPKEIALHVMCFLSPADIARISLTCRYWRNLAEDNRLWRKKCEEVNVTAMDEPRQVTVRIAAISLSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Q8</accession>
    <name>A0A183H7Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3520</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002371">
        <property type="protein sequence ID" value="VDO36810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Q8"/>
    <dbReference type="STRING" id="387005.A0A183H7Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0000351901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000351901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000351901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000351901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20327" checksum="F7E150FA08500902" modified="2016-09-07" version="1">MSDPVVEGWPAEQPESQHQQMHADNSQHSNKVLLYNCDGESSASFLRAARAGNLDRVLELLRSGTDINTCNANGLNALHLASKEGHHEVVRELLKRKADVDAATKKGNTALHIASLAGQELIVTILVENGANVNVQSLNGFTPLYMAAQENHESVVRYLLAHNANQVLATEVCPLYSSSLFSFSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7R4</accession>
    <name>A0A183H7R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SER_THR_PHOSPHATASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3528</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002379">
        <property type="protein sequence ID" value="VDO36837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7R4"/>
    <dbReference type="STRING" id="387005.A0A183H7R4"/>
    <dbReference type="WBParaSite" id="OFLC_0000352501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000352501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000352501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000198">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000352501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29975" checksum="C64636373E003CEA" modified="2016-09-07" version="1">MPCSLGKIKYSEKVYDACMDSFDALPLAALMNQQFLCVHGGLSPEIHTLEDIKKLDRFKEPPAFGPMCDLLWSDPLEDFGSERNSEQFSHNSVRGCSYFYSYAACCDFLQHNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELMADSDDTFEGMLHCGVPSARKEVIRHKIRAIGKMARAFSILRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8K3</accession>
    <name>A0A183H8K3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3815</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01002679">
        <property type="protein sequence ID" value="VDO37842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8K3"/>
    <dbReference type="STRING" id="387005.A0A183H8K3"/>
    <dbReference type="WBParaSite" id="OFLC_0000381401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000381401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000381401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="243"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO37842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000381401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64343" checksum="50BDC59FB3A7DA76" modified="2016-09-07" version="1">MNEGLLQAEEVLSDLKVKPLYACLIVECSDLRKLPSLQNNTLLRDYHSQNKNLRYVVHFTENSILSSDEYKSWMASFGENVEHIIVNGSGPCLPHMEAVYRINVIFNYICPKLFPLLHPIGFNGTIQQDDDCEKIGNHLYVRPFQRYFLRRPVNLDPSPPNVSLTPTDLLLQLKEDTATSEAIDLFMRSNIDANINLNFLVSNLLESTDNWPRICFLGTSSAVPTNFRNVSAYFLQFNENSCIFVDCGEGTYGQLRTLFGDEVSEDLLLKLNAVFITHGHQDHYHGIFTIVQCRKAVFRKRGITYKPLIVAAGSHVLKVFRDVDRSFGNYTGDMHIVDISKILWTLSQEKGSLVEAADLTGEMPSEIAGIEDLGFKSVVAVKVNHARTAVGYVFTDLKNRKFVFSGDTMPCERLVNHGKDALVLVHESTFADDEEAHALYKKHSTMKQAFDVATRMGAKNLVLTHFSAKYPKVPPLPDYIEKAGNVTIALDNMIVTPSDLKLSAKLIPVLRTVFAKEIIEIKQRSLKRHIQEDILARRFVDTLGDTVEKKRIPENLAFSDPVSSKFHDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8R9</accession>
    <name>A0A183H8R9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3881</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01002750">
        <property type="protein sequence ID" value="VDO38084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8R9"/>
    <dbReference type="STRING" id="387005.A0A183H8R9"/>
    <dbReference type="WBParaSite" id="OFLC_0000388001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000388001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000388001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO38084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000388001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24647" checksum="93ACF903D3642946" modified="2016-09-07" version="1">MNNNFIDPSVRYKERVTILRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRSLDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHGNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCANQAAMVELDDELRYSFLQFDPAPRKTETNVVRQTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8T7</accession>
    <name>A0A183H8T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3898</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002767">
        <property type="protein sequence ID" value="VDO38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8T7"/>
    <dbReference type="STRING" id="387005.A0A183H8T7"/>
    <dbReference type="WBParaSite" id="OFLC_0000389801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000389801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000389801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000389801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9763" checksum="0C0860BD82973F2C" modified="2016-09-07" version="1">MRTTRQKTYLTMALLAIILIYSFIDKQLTFFLDLIFYFTFFQGFGHYSSHIESVPTTSDLDGLVIAVKTTLKFHESRICDIIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Y9</accession>
    <name>A0A183H8Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3951</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002824">
        <property type="protein sequence ID" value="VDO38339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Y9"/>
    <dbReference type="STRING" id="387005.A0A183H8Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0000395001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000395001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000395001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF414">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO38339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000395001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="49554" checksum="E8688166D6F80338" modified="2016-09-07" version="1">MVTDVETMREYFIRNAEIFSNRWRNYATDFFMGGANGIIQIDGDKWKQQRRFVLRIFRDFGVGRILIEQQIMKEVEIFIDYLEAKCTAQEINLCTMHAVCVGNIITNILFGYRFPQGSAEFNSLHSLLDSHSRLVLHPLMGLYVTMPSTTMIPFVNYKWKQFKNLRDELWEFISREVQKHMKTFNCEETPEITDFTYAYLSEINRRKRAGEPNEYFSEWQLTMLLLDLFFAGMETTVTTLKWAFLLSIIHPDVQTKVQNELDGIGNRITLADKPKCSYTMATIHEIQRFANILPINLLRTVAEDVVMGKYYYPAGTLCIPQISIAMNDPKNFERPREFHPERFLEDDGFTLKKYDAFFPFSIGKRQCLGESLAKAELFLIYANLMRHFRFRTVPNEPNPSTKRLFGLTTSPPPYKCLVERRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAL0</accession>
    <name>A0A183HAL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">T-complex protein 1 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4522</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003465">
        <property type="protein sequence ID" value="VDO40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAL0"/>
    <dbReference type="STRING" id="387005.A0A183HAL0"/>
    <dbReference type="WBParaSite" id="OFLC_0000452101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000452101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000452101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000452101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12122" checksum="408D1762451C22C7" modified="2016-09-07" version="1">MLKNEVDKVKGRAKLGVQAYADALLVVPKTLATNAGFDAQETIVKLIEERIACKGKMPVGLDITSGEPCSPQNIWDNVVVKQNSLASACVIACNLLHVDEVMRAGMTNLKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAM4</accession>
    <name>A0A183HAM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SEC63 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4537</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003484">
        <property type="protein sequence ID" value="VDO40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAM4"/>
    <dbReference type="STRING" id="387005.A0A183HAM4"/>
    <dbReference type="WBParaSite" id="OFLC_0000453501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000453501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000453501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF5">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="9">
        <location>
            <begin position="163"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000453501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43943" checksum="F63A6817052CA7A0" modified="2016-09-07" version="1">MCYQISMHAYVVIIMDTQFYNGKYHVYEDYPIGDVLHMVGLANRPGIDDDAKCVLMCQSSKKDFFKKFLYEPLPVESHLDHCLHDHFNAEIVTKTIENKQDAIDYLTWTLLYRRMTQNPNYYNLQGVTHRHLSDSLSELVENTLKDLENSKCITIKNDMDTQPLNLGMIAAYYYISYTTIEVFSMSLSAKTKLRALIEIISNASEFANMPIRYKEDILLKQLADRLSGQQKHQKFTDPHVKVNLLMNAHLARIQLSAELNKDTEVVILKSIRLVQACVDVLSSNGWLMPAIHAMELSQMLTQAMFTNESYLKQLPHCSASLLERCKEKKISSIFDLLDLEDDVRQALLQMTPAEMSDVARFCNHYPSIEVEHKIENNGTITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW5</accession>
    <name>A0A183HAW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003605">
        <property type="protein sequence ID" value="VDO40545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW5"/>
    <dbReference type="WBParaSite" id="OFLC_0000462601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18625" checksum="7AE7B61180D7876A" modified="2016-09-07" version="1">MVVEGWLGIRAVRWRLLESGATGEVRHYTNGTQKPGLVARLPRIFVEQQPTAVSRPFFLSFVFQGPQWAVGRLTDWMQEYRRTDTNTAMMVGWIVVRTISDSPTPTNDGRLTGVFGTQYDNGNARSNQPTNQSSKQPKRTDCCVPPPLSSFFVLRQPTSSRTSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB04</accession>
    <name>A0A183HB04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransf_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4666</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003659">
        <property type="protein sequence ID" value="VDO40677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB04"/>
    <dbReference type="STRING" id="387005.A0A183HB04"/>
    <dbReference type="WBParaSite" id="OFLC_0000466501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000466501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000466501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF20">
        <property type="entry name" value="LYSOPHOSPHATIDYLINOSITOL ACYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="5">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO40677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000466501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="24127" checksum="FC12D5FBB34CDABA" modified="2016-09-07" version="1">MKSNVYAKKNGLKRLNNLIYPRSAGFIHLINEMRRHNYIECIYDVTIAYPVNTVQSEVGLFLTGRTPQKVLFHIERIDLSCIPIKDRDIAQWINELWIAKDEKLDLFYSQQPPRIHISNDQNKFIWKDDNPLHKIVKLFTLCFWSLMTAFWFYHLTFLRFVQVLFGYFIFVSASIYGKYGGIQRMVYIKWWHAMKAETVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB95</accession>
    <name>A0A183HB95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003776">
        <property type="protein sequence ID" value="VDO40958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB95"/>
    <dbReference type="WBParaSite" id="OFLC_0000475601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000475601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000475601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000475601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27304" checksum="0451210AEB086E9F" modified="2016-09-07" version="1">MGLSSPSGSPSPSYKFPNMDEDAPGSSAQQFTIKTNTDMADDTEKSSYLDDAFTTSMLKKNDEALGKLQQAIDNNENFDIGFHRSMIDELEWIDSHYHDNFRDDVSLVDNVFACKFNNTTDVQDKIAICEEWLCFLAKIIPIATSRWLSHYQFSIYYTFHMLALVFRHYENKDEKKRFYKISLPLFKSLLQATNLIPETSEEIVNTKLDVLLSISFIAVQFYDVSDQEIVKYIEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBE3</accession>
    <name>A0A183HBE3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4802</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01003840">
        <property type="protein sequence ID" value="VDO41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBE3"/>
    <dbReference type="STRING" id="387005.A0A183HBE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000480401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000480401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000480401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF244">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000480401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51962" checksum="C774F83F634ED448" modified="2016-09-07" version="1">MVLVLHCYGKGDIVVIYLPMILELPIAMLSCARIGAIHAVVFAGFSADALAARICQTEARLLITADGCYRGKKLVTLKAIVDDAVDECNALGKSVEKVIVLKHLERITKPSGVASIEMKLNPERDVIWDKEMERLKGVKSEIEWNDAEDPLFILYTSGSTGKPKGILHTTAGYMTYTYATVKFVFDANPERDVYWCTADCGWITGHSYLVYGPLLNGLTCVMYEGVPSYPTPARMWQIVEKYKVTALYTSPTAVRALMAFGNQYVTPYNRSSLRLLGSVGEPVNPAAWKWLYKVVGESRCAVLDTYWQTETGGHMITPLPAATPCKAGSATFPFFGVEPVILDNNGREVEGVANGTLCFKRAWPGISRSILDDHNRFVKTYFAAYPGYFYTGDEARRDADGYYWITGRVDDLMNVSGHLLSTAEIESALVSDGDVVEAAVVAAPHDIKGNFPYAFVTLRMVLFAAIRSAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBH7</accession>
    <name>A0A183HBH7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4839</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003876">
        <property type="protein sequence ID" value="VDO41214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBH7"/>
    <dbReference type="STRING" id="387005.A0A183HBH7"/>
    <dbReference type="WBParaSite" id="OFLC_0000483801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000483801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000483801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="9">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO41214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000483801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28898" checksum="E711E9727F522769" modified="2016-09-07" version="1">MSTTAEKKELPTVPETILKRRKQRAEQRAKANVKKAKLALKAKKKKLEIFKRAEKYVKEYRQRLRQEIQLKREAKKAGNFYVPDEARLAFVVRIRGINQMHPRPRKVLQLFRLRQINNGVFVKLNKATLQMLRIVEPYVAWGYPSLKTVHDLIYKRGYAKINGRRIPITDNTIVENALGKCDIICMEDLVHHIFNVGPYFKRATNFLWPFKLNNPSGGWTKKTNHFVEGGDFGNREDQINALLKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBS2</accession>
    <name>A0A183HBS2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18 kDa Sin3-associated polypeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4933</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003997">
        <property type="protein sequence ID" value="VDO41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBS2"/>
    <dbReference type="STRING" id="387005.A0A183HBS2"/>
    <dbReference type="WBParaSite" id="OFLC_0000493301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000493301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000493301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.550:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000493301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18716" checksum="B0FB64E1AF59C08B" modified="2016-09-07" version="1">MNVISQVEAPEEKTVDREKICPLLLRIFCANGRHNPLSEYGRGSTPANELQIYTWYIMLDCTLRELMSLIKEVNPDARRRGTTFDFAVVAPDRFTPRYVMRDIGNTMNGQRGVDDNKTLANCKFEIGDFIDVAITLPGIGPVGPILRRSGGLPMRDRSPVRRRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCG8</accession>
    <name>A0A183HCG8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5180</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01004312">
        <property type="protein sequence ID" value="VDO42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCG8"/>
    <dbReference type="STRING" id="387005.A0A183HCG8"/>
    <dbReference type="WBParaSite" id="OFLC_0000517901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000517901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000517901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000517901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42834" checksum="9C77A19342241D58" modified="2016-09-07" version="1">MVAWDAHLKRDKSIIVDLFTGQLRSTLTCLNCNAISCRFDAFTCLQLPIPIDHLLLISVVVVKRDGQIPIRYAFRLTYDTTIGMFKNKLAEACSLLPNSFQILCLNRAGQMMQGVSESVDDDNSSISVYPNDALLYAFELPAEEDQSNPQCFIAAPTVIAAHRKMQYNDSYLLGATRGCTARVFGVPLILRFTPGKTTGNKLYEEVWLHVSRFLKNSGVGKQQRIREANRAIDAAEDIRNGYPFDLCCVKLSFEWCSKCAWPAFCRGCVILSNNEIIEDCLMAVAIDWKPTALYLRYQHSVELLCRDDASVLQAWEIHYRPCSLLSCLNDFMQAECLDDEIMCKPCGKKCPATKALAIWRLPKILVRFYHMYVSKIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCZ0</accession>
    <name>A0A183HCZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004552">
        <property type="protein sequence ID" value="VDO42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000535101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000535101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000535101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000535101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26239" checksum="A9C3D232FEB2B77C" modified="2016-09-07" version="1">MSPDDIPSAKNSSFLSLFSRKKRINRSITESLDENKTITSPSNARFLTNGQKPTNITHTNGYGNLENSEMLMVPLEPASTSWAKEFPLPHQSLPQQQQQQSKTDFAFPDRKRYYQNSRMHQHISGENSDILSNNNRSRSESRAMTDKSPVLMLSKKAYSVDTMNNHSDPGYLMEALETLADTQPRVARSIPKHAIVDTSNFAARSLDNCLFDATVYDAMLHDSLKRNINNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE51</accession>
    <name>A0A183HE51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5762</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005127">
        <property type="protein sequence ID" value="VDO44233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE51"/>
    <dbReference type="STRING" id="387005.A0A183HE51"/>
    <dbReference type="WBParaSite" id="OFLC_0000576201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000576201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000576201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF9">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO44233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000576201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18796" checksum="E3461B6B4ACFEAA4" modified="2016-09-07" version="1">MSVFAFRVNSEYAKMTEIIPGLFICGVSSLNSSSISHYGITHIINATNEVPNLKSLTNIQRTKLWIDDTSETNIYPHLEQQSDLIRTIIADGGKVLVHCVAGVSRSASICLAYLTKYHCRTLRDAYHLMSKKRSLVRPNIGFWRQLISFEQAKVHSIFSNDLECKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEQ2</accession>
    <name>A0A183HEQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate cyclase type 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5963</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005416">
        <property type="protein sequence ID" value="VDO44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEQ2"/>
    <dbReference type="STRING" id="387005.A0A183HEQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000596301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000596301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000596301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000596301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21334" checksum="6CC2635413A2AB24" modified="2016-09-07" version="1">MSIDRCACEIVDAVLREKSIVFVPRYMSLIAYFRGLLPERVEDAWREYLNCQYEPLEDQEMEDEEITLAKKTDYFEGLDASKKYMLLIAYLIIMISYLVMQGVMQTMLQTLVLFIVTLNFVLAICALHFCDQLKFSFPCKFRWFMQIFCFGFISFLQLCRFGYSSGISRKKYSSPTDNHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEQ3</accession>
    <name>A0A183HEQ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">GPI alpha-1,4-mannosyltransferase I, catalytic subunit</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS5968</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="UZAJ01005421">
        <property type="protein sequence ID" value="VDO44960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEQ3"/>
    <dbReference type="STRING" id="387005.A0A183HEQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000596401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000596401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000596401"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO44960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000596401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20570" checksum="1C850431243A0639" modified="2016-09-07" version="1">MNSRKSEYSFTLWCLAALIYGLLAIHLKLYPIIYLPSIFLFLSNISLHCGWIDYGKRLISNVKGYIFILIFSSSLLALMTIYYMLYGMPYINEAFLYHLHRTDTRHNFSPYFYLLYLATNDTQLSRLISFCCFIPQALLIIWLAFRFHDDLPFCWLLTTAVFVSFNKISTKTATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HES5</accession>
    <name>A0A183HES5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tho2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5987</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005448">
        <property type="protein sequence ID" value="VDO45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HES5"/>
    <dbReference type="STRING" id="387005.A0A183HES5"/>
    <dbReference type="WBParaSite" id="OFLC_0000598601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000598601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000598601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000598601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39245" checksum="1FBC553A4DA6D994" modified="2016-09-07" version="1">MYDISVPKATYERELQRVRRSLALVAENAEISKTKRAKEEEQLRNVEKKLTDELKKQNDHVERILNILKHDKELLFADCSPKLRGTQMARFLQHCILPRAVFTDMDAAFCAHFILLLHQQRTGFFQTVFFFDKLFNDIGTILATLTENEANCLGRFLALVLETVQHWHSDKVVFEKECYRFPGFMTKLHMRNPEATNTESISDGMNYESYRTLCHKWQYRMTRSCLGILDGSNYVMMRNCLIVMIKMLAYFPLIENHIANIEKTVNKVHETEKGRRDDLSLMAASYAGHLRMRKTHTYTESQFHNVIIFHCFLQSILKFFKSILKFSPQVRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF01</accession>
    <name>A0A183HF01_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6064</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01005555">
        <property type="protein sequence ID" value="VDO45276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF01"/>
    <dbReference type="STRING" id="387005.A0A183HF01"/>
    <dbReference type="WBParaSite" id="OFLC_0000606201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000606201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000606201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KA1" evidence="10">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO45276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000606201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23479" checksum="AB7DA6B265AFAEAA" modified="2016-09-07" version="1">MIRNNLKKIYDERPRSNPYVTPLRYPSCIPSAKMRSRSIERNETSLRTPVQSSTTCQIHTPRSSSKTPRLRQRVFASLERQADKVINLLTPRRVKNNQPEMLKQTRAMVNVSITSSKNPDRVRRELLRVFAEQEITAEQHGWKISGRRKDEFNRMMTVELEVVWIEMGNKEKLVGVKRKRLNGDAFLYKKVCEQVLQLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF37</accession>
    <name>A0A183HF37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromodomain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6098</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005606">
        <property type="protein sequence ID" value="VDO45386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF37"/>
    <dbReference type="STRING" id="387005.A0A183HF37"/>
    <dbReference type="WBParaSite" id="OFLC_0000609801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000609801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000609801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000609801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16621" checksum="EE9DE6FA5051BC81" modified="2016-09-07" version="1">MPSQKQIPTPNPSMPSQKQIPTPTPSMPSQEVQKKPSSSSLVDPEQPGPSWKRFPEPRIPSEQSKRPSQATAQKKSQMDEDARYMLKRQITLSEMLLRREPLFVDAPLNIDPEVNRDPPRQERRRKPFQEKSQEENTPKHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFH8</accession>
    <name>A0A183HFH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6240</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005821">
        <property type="protein sequence ID" value="VDO45880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000623901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000623901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000623901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552514" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000623901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13137" checksum="E7BE339F310F5B45" modified="2016-09-07" version="1">MLHFQMVNTRLLTLLLWFNYCSILDSGSVDSDSVVSIICDYRKEIVDNTHVSHRVRNAIRRLPYHSRRNSIDNERKWQQVIIVGNGELIVDQVAEWLRRWTANPLGFPRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGW0</accession>
    <name>A0A183HGW0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6722</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01006559">
        <property type="protein sequence ID" value="VDO47667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGW0"/>
    <dbReference type="STRING" id="387005.A0A183HGW0"/>
    <dbReference type="WBParaSite" id="OFLC_0000672101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000672101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000672101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="70"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO47667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000672101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39760" checksum="E5ACAB82A243AC23" modified="2016-09-07" version="1">GIVVPGGFGGRGIEGKIAACKYARENNIPFLDLFYIILHFIFLNILIFQCLKMKKMHRFHYRLFHFLIAVINFLGICLGMQCAVIEFARNVCGIKGANSTEFDKTLVGEQQVVIDMPEHRGEEKGMGGTMRLGLRDTVFLTNNCKLRRLYDARKISERHRHRYEVNPRSVPKLSRAGLLFIGMGADGNGAHMNGSVSSYTSLMKLAESKTTKAVEENDTQEVYEISDAQEREVLLSKIEDLCRIENETDTTSVRMEIFELQGHPFFVGVQFHPEYLSHPLQPSPPFFGLICAASGQLESFLRGSKIPSPMSVLKAAENYSSDVAENVLQATHLFVNKVGIFPDQNTDEAQLNGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGY5</accession>
    <name>A0A183HGY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD_binding_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6747</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006600">
        <property type="protein sequence ID" value="VDO47787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGY5"/>
    <dbReference type="STRING" id="387005.A0A183HGY5"/>
    <dbReference type="WBParaSite" id="OFLC_0000674601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000674601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000674601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630664-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO47787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000674601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35566" checksum="F5482DE1570EB300" modified="2016-09-07" version="1">GAGLRAASRLGEGGLRVAIITKLFPTRSHTVAAQGGINAAIGSMNPDDWKWHFYDTVKGSDWLGDQNAIHYLTKDAIRAVIELENYGMPFSRTAEGKIYQRSFGGQSNDYGKGGVAKRTCAVADRTGHAMLHTLYGTSLQFHCHYYIEFFALDLLMDKERCVGVIAMNLEDGTFHRFRAPFTVLATGGFGRAYFNCTTAHSTTGDGNAMAIRAGLQTTDMEFIQFHPTGIYGVGCLITEGSRGEGGYLVNSEGERFMKKYAPKALDLASRDVVSRAMTVEIIEGRGVGKEKDHIYLQLHHIPADHLHTKLPGLYIYIYNHSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHN7</accession>
    <name>A0A183HHN7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS6997</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01007019">
        <property type="protein sequence ID" value="VDO48807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHN7"/>
    <dbReference type="STRING" id="387005.A0A183HHN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000699801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000699801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000699801"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="87"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO48807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000699801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49025" checksum="ECCF2849FF51D26E" modified="2016-09-07" version="1">MGAEATIALLEMNEDSEPCVVSIDGNQMVRIPLMKCVERTKAVKTAMDIKDWATALKLRGRTFRRNVEMYRTLSKIRKHELPSEGFNIAIMNVGSPCAGCNAAVMSCVRTAILQGCVPYCIYNSNEGLATGQFQKMDWNDVSLWSSEGGSFLGTQRTLPSNDMLPLMAKNLLRFNIHSLIIIGGFNAYHTCLILAQNRETYPPFRIPMCVIPSTINNNVPGTGFTLGADSSLNEICKMIDKIKQSATGSKRRVFIIETMGNYCGYLATLSAMASGADAAYIYEEIFDVHELLNDIRVIAEKMQTGAQRYLIVRNEKASENYTSEFIRQLFTEEGKGIFSTRTNILGHTQQGGNPSPFDRLFGAKMGARAVVHLLEQMKEYKKTNVHHPGTATLQGLIGKHVCLTPVEELVEDADFVHRLPMEQWWMKLRPLLRILAKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIF8</accession>
    <name>A0A183HIF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007466">
        <property type="protein sequence ID" value="VDO50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIF8"/>
    <dbReference type="STRING" id="387005.A0A183HIF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000726901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000726901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000726901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000726901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26817" checksum="76C8D05CA70258ED" modified="2016-09-07" version="1">MSRMKKMSHSLSRVNEVYSALETRYALLSMTFRKYIDNDSCCFIAGKVLDEGFSVLRMLDSCIKRKVQPPETQESLKDIRDYSSMAMEYFEEQIAPALRIRDPLTLLCRSHSRFSLESLPSSFSSTKLSDSVRSLCSTSSSSIVISRNSSSPMRPNLDDFAKMNQWKKKIDDKVKQHERIIAEQDRVIREQSKAINSIIECMHQVIFFFYHIKYQFLTNRESSLSTIVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIJ2</accession>
    <name>A0A183HIJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7306</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007528">
        <property type="protein sequence ID" value="VDO50321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIJ2"/>
    <dbReference type="STRING" id="387005.A0A183HIJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000730301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000730301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000730301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000730301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22305" checksum="C517415677B96F0E" modified="2016-09-07" version="1">MQFAAGEAHVEGARPQQGNHQITIHTARYQTQPVQTQQNYPTSQLAYPTAPPSSMYNSNAIYSAHNFIPNSPQSFYYPPVVAPVYSYFPPAQPADYINPAAAAAARMNVGYNQNPFLIQATAAATPPAAPSTTTTTSGITSNMPQQPPQQLTKTKKILSIVDPMTNEVTNKDHIIRSEKEQQQMMQQNVENADTGKFNLSFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIK9</accession>
    <name>A0A183HIK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase_M41 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS7320</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007552">
        <property type="protein sequence ID" value="VDO50387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIK9"/>
    <dbReference type="STRING" id="387005.A0A183HIK9"/>
    <dbReference type="WBParaSite" id="OFLC_0000732001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000732001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000732001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M41" evidence="13">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO50387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000732001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24055" checksum="C7E1455790D2A167" modified="2016-09-07" version="1">MVEEEREIVAYHESGHALIGWLLEHTDALLKVSIIPRTSVKLGFAQYSPRERKILTKEELFDRMCMLLGGRAAENIIFGRVTTGAEDDLKKVTKSAYAQVQLYGMSETIGPLSFPIMDDSKRNELEIYKKPFSMKLQHLIDQEASKLVSKAYFTAEKILKMNEKKLKKLATSLLEKEMLSYEDVIRLIGPPKFPKQVVELADHVLPNVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ66</accession>
    <name>A0A183HJ66_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS7528</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01007922">
        <property type="protein sequence ID" value="VDO51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ66"/>
    <dbReference type="STRING" id="387005.A0A183HJ66"/>
    <dbReference type="WBParaSite" id="OFLC_0000752701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000752701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000752701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000752701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17959" checksum="BADAE2DFFA414D84" modified="2016-09-07" version="1">MQGDGICYESIGNILDAVTRNKWSADNIVFGTGGALLQKLDRDTQKCAFKCSHVVINGESRDVWKSPTTDAGKQSKQGRLTLERREDGNFVTIEKGQGDISKDVLVTVFENGRLLVDYSLEEIRDRAELDIVKEHKRKAVNVEAAVKTINGGSWVSANGNFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJP3</accession>
    <name>A0A183HJP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BBSome-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7706</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008218">
        <property type="protein sequence ID" value="VDO52247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJP3"/>
    <dbReference type="STRING" id="387005.A0A183HJP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000770401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000770401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000770401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028233">
        <property type="entry name" value="BBIP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596:SF1">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14777">
        <property type="entry name" value="BBIP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000770401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8436" checksum="5F3B6366AB90C025" modified="2016-09-07" version="1">MDSEIKEILNARNGLLFCEEELSPVFCKPKLIPLKSVTLEKLEKMQSDAMEMMKKMEESKNKISIEVNFLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT9</accession>
    <name>A0A183HJT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cnd1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7751</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008292">
        <property type="protein sequence ID" value="VDO52405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT9"/>
    <dbReference type="STRING" id="387005.A0A183HJT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000775001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000775001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000775001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO52405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000775001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35595" checksum="C76874B636735BDD" modified="2016-09-07" version="1">MSLTTKEWTSTNIAKLLDSFDRVGNGNFDEFIGGNVKITEKILLRLNDNIHDIVDEALKEGGWRLRRITNVFQHWPTNMQENVLKLLFKHGKWTEETRNAFCSCIASLFIVNVRAGRNVTTICKEEHKKLLQKLSKKQDTGVKLPVINGTLSIFMNVLTLWIAAASDSNERHSYLRDLIETAAISEKMIENDNTNSVAVLNDLLFSLLSQPHRYHRSVVHYVFASFVPQMKLENLLQIFETINLSNEELMQEKDVSESDDQDDEDEDEQENSEQISEENEVNNNGNVTDHQEETDESEFEEDEVGSEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK79</accession>
    <name>A0A183HK79_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7891</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01008541">
        <property type="protein sequence ID" value="VDO53015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK79"/>
    <dbReference type="STRING" id="387005.A0A183HK79"/>
    <dbReference type="WBParaSite" id="OFLC_0000789001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000789001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000789001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO53015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000789001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33633" checksum="5EE86D6C7034F787" modified="2016-09-07" version="1">MEFVNSKFKLYSGYFQVLTQYKKLAGGGYIGFNNATFLSERDTADRNYALSYYMKENNCFPGSVSLRDELDFYFQLCSLETTCESAAVMAATLANGGVCPLTNEICISARPCRDVLSLMYSCGMYDYSGQFAFQVGLPAKSGVSGAMIVVVPNLMGICIWSPPLDKMGNSVRGVSFCKKMIETFNFHNYDSLLHADTKKIDPRKRGMPNESELILEMMFATKKGDIDDVRRMFLGGVNLNMSDYDGRTPLHLAASEGQSLMVDFFLDIAHVNPLVRDRLVINTLIMFEKNIVNKNTYINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKH3</accession>
    <name>A0A183HKH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutS domain V protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008710">
        <property type="protein sequence ID" value="VDO53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKH3"/>
    <dbReference type="STRING" id="387005.A0A183HKH3"/>
    <dbReference type="WBParaSite" id="OFLC_0000798401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000798401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000798401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF145">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS clamp" evidence="5">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="4">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000798401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25092" checksum="AAA2AD8F45972F06" modified="2016-09-07" version="1">MHEIEIKCNTLLKKVCSGITEAIKLENTESHGFHFRVTLKAEKSIRQLGMHILETSKGSGVRFTCVDLDELNREYRKFSSHYEAVQSKFIDMIVETCSGYVPTFCELSEAIAIIDSLVALSVLASGSSSAYVRPQILDEGKQVLELKKCRHPVMEANPNSSQFICNDIVLGSEQGDNTMFLVLTGANMGGKSTYLRCCALSVLLAQMGSFVPCESARFSLIDGIYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKM8</accession>
    <name>A0A183HKM8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8042</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01008813">
        <property type="protein sequence ID" value="VDO53772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKM8"/>
    <dbReference type="STRING" id="387005.A0A183HKM8"/>
    <dbReference type="WBParaSite" id="OFLC_0000803901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000803901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000803901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO53772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000803901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24287" checksum="6465C5CE6ECB0D6A" modified="2016-09-07" version="1">MMLIAVNHTGSGFLSNKEIIEEGDTVIIYVNYGTSYAVEVKRGLILTMRYGALKHEYLIGKRYGSRISATAGYVYVLRPNAEMWTRALLRRTQIIYTPDCALILMLLDVKPGSIVCECGTGSGSLSHALAMAIAPTGHLYTHDIEGTRVKQVEVEMMKHGLGEITTCVHQNVIEDGFSVENICDAVFLDLPAPWVAIKHAKRALSQVQGGRVVSFSPCIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL85</accession>
    <name>A0A183HL85_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8248</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009174">
        <property type="protein sequence ID" value="VDO54773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL85"/>
    <dbReference type="STRING" id="387005.A0A183HL85"/>
    <dbReference type="WBParaSite" id="OFLC_0000824601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000824601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000824601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO54773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000824601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16909" checksum="4F071E7E81767AE2" modified="2016-09-07" version="1">MCSTLFREERAEFRYHRAVELRPYAERLLQFGIFRGPNDPYTKEMVNWWIMDGDIREKFFEVYVPRFREKEGPFTSLYLIQDDPSEGHYDRGVIELNGNPYPPIVIEEMDHSHNLLNVLLKNAIYQQMSNLQIQHADIISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLQ2</accession>
    <name>A0A183HLQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ninjurin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009492">
        <property type="protein sequence ID" value="VDO55569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLQ2"/>
    <dbReference type="STRING" id="387005.A0A183HLQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000841301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000841301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000841301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000841301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8359" checksum="A813A54C95DB4ED8" modified="2016-09-07" version="1">MDDCTQIYNNNNSPTTSYGGVLSRDVTGSVAQSLTNRSAINDGIRKLDKAPLMTGTENFVVFLTFSLLLNVTILAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMN5</accession>
    <name>A0A183HMN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8746</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01010130">
        <property type="protein sequence ID" value="VDO57184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMN5"/>
    <dbReference type="STRING" id="387005.A0A183HMN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000874601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000874601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000874601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF347">
        <property type="entry name" value="PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO57184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000874601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23377" checksum="CBFC297F1F6D55DD" modified="2016-09-07" version="1">MHYDLHLFINKNSVCAVVCHHRCKQYMPNLCGVNQKQLSQALFEIKRGGHGQTSTPVGYGGSSLEPGAPEPRSVSSSSSNGSASSGYKFPDRFKAFFRYHNYNLDNQCDNEEYISAPWSTADGIKKYGLQHFNICKVLGKGSFGKVLLVELKNKQKYYAMKCLKKDVILEDDDTECTFIERRVLILSSQCPFLCQLFCSFQTNVNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMW2</accession>
    <name>A0A183HMW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8823</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010295">
        <property type="protein sequence ID" value="VDO57573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMW2"/>
    <dbReference type="STRING" id="387005.A0A183HMW2"/>
    <dbReference type="WBParaSite" id="OFLC_0000882301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000882301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000882301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000882301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27350" checksum="EE5596C711BE8B85" modified="2016-09-07" version="1">MMQCWAHKPEERPSFTDIVQHLPEIMPQRLVTVTSCCDGIIDHLQYAKNEIIIVLDRWLEFNWNFSPPTYPDGYFWRGCMRNGRTGLFRPEETVAKLDIKLPNNKFDKYLSSVFFSHSKTFFHEKQKVQDKNNRKKLLISEPQGDVHHTCHIGVDGTAFGLLQVNVHFLKLPLQLFLNVHSDLVTLPVVNQKAKKHLKTWNEDDKYVCDIHIMEECHPETKGPYDIFPSSKKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNG0</accession>
    <name>A0A183HNG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9021</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010673">
        <property type="protein sequence ID" value="VDO58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNG0"/>
    <dbReference type="STRING" id="387005.A0A183HNG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000902101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000902101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000902101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000902101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10690" checksum="9C0F1BB5B6251809" modified="2016-09-07" version="1">MITQKGSLILWNHFLISNFKGNGYIAVSDLRDILRALDENISEDELDEMIADIDTDGSGTVDFDGELELHFYNLEEIHSDFRILQFMEMMSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNY9</accession>
    <name>A0A183HNY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011041">
        <property type="protein sequence ID" value="VDO59159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNY9"/>
    <dbReference type="STRING" id="387005.A0A183HNY9"/>
    <dbReference type="WBParaSite" id="OFLC_0000920001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000920001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000920001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000920001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20272" checksum="794685824BAB7F11" modified="2016-09-07" version="1">METSLNRVLSFRLSNKKAQVIPSKISVMGQIVSCPDIIKRSKPCPSAYQGVDLSAINDLAISFYYDIELSVLKHDLFSNPFELMAFQFDKPMPLNQSEMPEFICLTEVASEAVINADGIAEGLLFWFDVENGKQLYSTRSSNTLARCALYLFDKGRKVSKNDRLSIKSSNYHGNLIFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQA4</accession>
    <name>A0A183HQA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9666</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012112">
        <property type="protein sequence ID" value="VDO62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQA4"/>
    <dbReference type="STRING" id="387005.A0A183HQA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000966501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000966501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000966501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000966501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28872" checksum="9191FF30873EA830" modified="2016-09-07" version="1">MAEPSDAIRIDDVENSSDDEEEDEEESSMESDENSAEESSSEDESEEKSSDDDGDDDTNVWDSVDDGAQTEEAVEASLQADYTTALNLIINGRRQKALAMMKKLLQHPILQKFEVNINLFDWNEARKEARANQSRVSAMARLFSSLHFNISRLLDDPIDHLLNLNFIFCLNTKQSTFLLKFLFYLSMLQALTVYPNDDYLWKYVGEESLKVRDWSMALFAFGNCSSAWSVIRGTLIALYNANLFEGFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSE4</accession>
    <name>A0A183HSE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10406</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013834">
        <property type="protein sequence ID" value="VDO68223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSE4"/>
    <dbReference type="WBParaSite" id="OFLC_0001040501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001040501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001040501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001040501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11095" checksum="C58983E38061AAFA" modified="2016-09-07" version="1">MQGKSARKSSNVAINNDSKINLDTTIGCFTLLESIILITIIGLLSTIVFSFSIINYFRPAILITIIPITVTSITLYGILRQKHSYLWPLIAHSVSYYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSH5</accession>
    <name>A0A183HSH5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS10434</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01013897">
        <property type="protein sequence ID" value="VDO68416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSH5"/>
    <dbReference type="STRING" id="387005.A0A183HSH5"/>
    <dbReference type="WBParaSite" id="OFLC_0001043601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO68416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7109" checksum="DC355BB79A6EF609" modified="2016-09-07" version="1">MNDLEVKIHDVWANNLEEEFKRIRDTVKEYPFVAMDTEFPGVVATPLGQFKSKEDFNYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTF3</accession>
    <name>A0A183HTF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10765</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014729">
        <property type="protein sequence ID" value="VDO71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTF3"/>
    <dbReference type="WBParaSite" id="OFLC_0001076501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001076501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001076501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001076501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="7971" checksum="29D7F5741D96CF5F" modified="2016-09-07" version="1">MVVMVVADGNKGAIKVIVDGNKGVLVNEDGTAVVFKIARNSRGIKNIAKIGSYWCEFGGIRIAASQGGAICDCGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTH8</accession>
    <name>A0A183HTH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Digestive organ expansion factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10798</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014820">
        <property type="protein sequence ID" value="VDO71406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTH8"/>
    <dbReference type="STRING" id="387005.A0A183HTH8"/>
    <dbReference type="WBParaSite" id="OFLC_0001079001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001079001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001079001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001079001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17698" checksum="4027CE74F9A489F1" modified="2016-09-07" version="1">MSGNTDDCFRIGVALAKKSLKLYTAFDESDILIASPLGLRMIIGESDGINSERETDFLASIEVLIIDKADILLMQNWEHLLNIMSSLHIQPKKFTTDISRVRRWSLEQYSKFYRQTMLISEKRHAECDALFVLYCKNFAGFVKLLTSSQGLLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTK7</accession>
    <name>A0A183HTK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid-transporting ATPase IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014862">
        <property type="protein sequence ID" value="VDO71553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTK7"/>
    <dbReference type="WBParaSite" id="OFLC_0001081901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001081901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001081901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001081901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9404" checksum="4BB47394E2EAD7FD" modified="2016-09-07" version="1">MANVGRDHQVRKDQRGNADRKVKKAMTVRMENLDHKVNQDQMVRLAPTDVMAETVNLAYLVLLDYQGKMQTIVRVHCLVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTQ1</accession>
    <name>A0A183HTQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014976">
        <property type="protein sequence ID" value="VDO71945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001086301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001086301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001086301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001086301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6903" checksum="E1D986CAF3EE98B9" modified="2016-09-07" version="1">MKSVVTVVEADNCCGSRRFRGKDVLIPRILMIPMDMPFQFKKLQFPIRLVFLFTIDNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTQ9</accession>
    <name>A0A183HTQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10872</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015005">
        <property type="protein sequence ID" value="VDO72037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTQ9"/>
    <dbReference type="STRING" id="387005.A0A183HTQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001087101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001087101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001087101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034518">
        <property type="term" value="C:RNA cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901190">
        <property type="term" value="P:regulation of formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040160">
        <property type="entry name" value="Mxt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001087101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17776" checksum="CAA7B07B9C9ACE45" modified="2016-09-07" version="1">MNQINTSVKSGLFNAQLANQIFVLCQQLKYSGQLLEQSHKSELNRVFVSLRQACCRDNGQLGTPCRLKMMELVELRAMGWRPSLAHTQYYLNRPEQQQQQQPQQQIGTFNSHKLIYSAPVSAPPFGTIPVNPFGNFGGPPPPLYVGGDVNSPVIAPQPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTX6</accession>
    <name>A0A183HTX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10938</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015185">
        <property type="protein sequence ID" value="VDO72539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTX6"/>
    <dbReference type="STRING" id="387005.A0A183HTX6"/>
    <dbReference type="WBParaSite" id="OFLC_0001093801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001093801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001093801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FRPR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001093801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6587" checksum="71090AF6AA720E8B" modified="2016-09-07" version="1">MYTVVMAVGPVLVLIILNSAIIIALRDPLSVSGDSDIITLVVVVCLFIICNILVSFISGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU85</accession>
    <name>A0A183HU85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11047</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015443">
        <property type="protein sequence ID" value="VDO73402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU85"/>
    <dbReference type="STRING" id="387005.A0A183HU85"/>
    <dbReference type="WBParaSite" id="OFLC_0001104701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001104701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001104701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001104701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14281" checksum="11A904F5E19D6012" modified="2016-09-07" version="1">MILNALLQKSEAWNNKIIPVLASKATEQLDLPRWECRDNALSQLIVLVKYGYNGSDLIQCITNMAKNDEEPYVRGQALVFLNQIGNPVDVKNVAGYVLLSDSDSAPRLILLLHEFRGLKLMSRLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUF3</accession>
    <name>A0A183HUF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11115</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015637">
        <property type="protein sequence ID" value="VDO73976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUF3"/>
    <dbReference type="STRING" id="387005.A0A183HUF3"/>
    <dbReference type="WBParaSite" id="OFLC_0001111501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001111501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001111501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO73976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001111501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38137" checksum="569E0FB5639954C3" modified="2016-09-07" version="1">MSGKANITNVNLQSDNHTILAYDVDVTKEDDVRQFLMQIMLQHRRINVIIHAAAAKIDNTKFEKSFDEIEFVLQPKIRGIRNIIDALCQNNINVRNLILNSSMNGLFGLPGNNDYATSNIFLDACCRRNLRNIHNVTTIQWTGWKASKMFNYYWMKEKKSQNPVANLIIEYSLSVPEAERMIWKCLHEQGLIAVSNVSPNDIAREIYKLNFTINRKFTNIPDEDFESKIETNSNDLRNIIAKIWMNYLGVEQLTDQDDFFQLGGHSLNGMQIIWEINRMMRINCKLDDLFKNSQFENFLQFLQQLAIEGNQQKFSHNLENYEILDATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVG5</accession>
    <name>A0A183HVG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FctA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11480</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016620">
        <property type="protein sequence ID" value="VDO76793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVG5"/>
    <dbReference type="STRING" id="387005.A0A183HVG5"/>
    <dbReference type="WBParaSite" id="OFLC_0001147701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001147701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001147701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040094">
        <property type="entry name" value="Lbp1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22725">
        <property type="entry name" value="FATTY ACID-BINDING PROTEIN HOMOLOG 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22725:SF9">
        <property type="entry name" value="FATTY ACID-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO76793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001147701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13316" checksum="A8D026F814E27B53" modified="2016-09-07" version="1">MISFASVTKVLSHSDETRDAYNLSNLTSKKNTVYKNWKLKEEFQAEGLDGKMHQITFDFDPATDSLKETHIRMDDPNDHGETYTYTVDGDTLTLVTFSLIHCGDTNKINLHSKLTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVI5</accession>
    <name>A0A183HVI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11496</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016651">
        <property type="protein sequence ID" value="VDO76872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVI5"/>
    <dbReference type="STRING" id="387005.A0A183HVI5"/>
    <dbReference type="WBParaSite" id="OFLC_0001149701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001149701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001149701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001149701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17058" checksum="0103269C674BD112" modified="2016-09-07" version="1">MKKRYCVLRKDENGKVLLEMRKSQFAASTHSPMIVQQAALSTSRKGKSVLEVKGSGAERRSWVLAADSDSDLPRWLIELDRALANGFKDYGFHFYNYCCSHNFQLNLCKFQILHKEAEMKPCQQVTNFCIQKSKLLCEQNITANSIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW23</accession>
    <name>A0A183HW23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017183">
        <property type="protein sequence ID" value="VDO78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW23"/>
    <dbReference type="STRING" id="387005.A0A183HW23"/>
    <dbReference type="WBParaSite" id="OFLC_0001168501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001168501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001168501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001168501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28121" checksum="E32B88FD0336B1C3" modified="2016-09-07" version="1">MNVTGYAVLNKRQLKLIYGQQSPYRHPVALKRLSKLSGQSDRLRKSLENDLKKLARSEDFGLNQEKIHQRKKRSLFFSPFVLSPFISDAENLSQPIVLSPIVLSPVVLSPAVLGPFILSPWIFNPVLLSPRILAPFILNPFIFSPLILSPLALHPFILSPGIFNPLILSPLTLSPFILSPQVATPIILSPMILNPLIFNPMALSPIVLSPLLLSPIVYSPQFLFALLISPHILSPQVHSPLINSTIILSPSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW87</accession>
    <name>A0A183HW87_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS11754</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01017414">
        <property type="protein sequence ID" value="VDO78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW87"/>
    <dbReference type="STRING" id="387005.A0A183HW87"/>
    <dbReference type="WBParaSite" id="OFLC_0001174901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001174901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001174901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552660" description="6-phosphofructokinase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDO78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001174901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24329" checksum="E1F0B40C647FF896" modified="2016-09-07" version="1">MGRHCGYLALVAALASEADFCFIPEWPVPTDWPTVLCHKLRMMREAGSRLNIVIVAEGALDREGKCITAESVRAVVKETLHYDTRTTVLGHVQRGGSPSAFDRLLGCRMGAEAVLALMEMTPESDPCVVSIDGNVIVRVPLMQCVQRTQAVKKAMDERDWETAVKLRGRSFQRNLQTYRLLTKVEPKKNFADPPGLVHNLAVINVGAPAGGLYFIIFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWE0</accession>
    <name>A0A183HWE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sodium/potassium-transporting ATPase subunit beta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11804</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017547">
        <property type="protein sequence ID" value="VDO79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWE0"/>
    <dbReference type="STRING" id="387005.A0A183HWE0"/>
    <dbReference type="WBParaSite" id="OFLC_0001180201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001180201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001180201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001180201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9188" checksum="ABD8225CE79D91A3" modified="2016-09-07" version="1">MNGRGKANGAVGDQTFSKFLFNKDKGTCLGRTAKSWVQILAFYLVFYSLLIAFWIGCLAIFLSTLDDKVPRYYGKGTIIGVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWE2</accession>
    <name>A0A183HWE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017543">
        <property type="protein sequence ID" value="VDO79363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWE2"/>
    <dbReference type="STRING" id="387005.A0A183HWE2"/>
    <dbReference type="WBParaSite" id="OFLC_0001180401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001180401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001180401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001180401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19578" checksum="44B76170601CC4D6" modified="2016-09-07" version="1">MGSYSHSVKSALEQGPINDHNFYTQDEVKYHGSKNRGVHPIEFVSIDEKPPSIRPPPRFQQQNPPQHPSNMNDSSNQQTEVSLSTITRSETTSSVTSATVRPSGSKPTLKPKTESTTKKQLLVKSKSTSVPQSEPGPKMKTQETDYLYFDNGSISPMLSRSDYCICLLLLLLYCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX06</accession>
    <name>A0A183HX06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12015</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018098">
        <property type="protein sequence ID" value="VDO81160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX06"/>
    <dbReference type="STRING" id="387005.A0A183HX06"/>
    <dbReference type="WBParaSite" id="OFLC_0001201801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001201801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001201801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO81160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001201801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="19400" checksum="63298193EA0FD2E0" modified="2016-09-07" version="1">NRCEGCCITGPAGPKGPPGRPGKPGKPGSPGLPGNPGRPPPQPCEPVTAPPCKPCPPGPPGPQGPPGPRGDPGTDGAPGAAGQDGLPGEAGPQGEQGPPGTPGPAGPNGPPGENAPDEPIQRGPPGEEGDQGPQGPTGPAGQPGQDGAAGPPGPPGQPGADGQPGPDGQPGAPGPPGPPGKPGERGVCPKYCAIDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYJ0</accession>
    <name>A0A183HYJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12552</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039866">
        <property type="protein sequence ID" value="VDP11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYJ0"/>
    <dbReference type="STRING" id="387005.A0A183HYJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001255301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001255301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001255301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001255301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35562" checksum="4CEC54CCFB9D35C8" modified="2016-09-07" version="1">MRKKRGLIVGAYRANMESLFPLCTRKKQAQFPAKLLFANQQIMRNAVNPFALRRGNTAQINDESGSKQRFAPIIIGCLPTASQQSNMLTSLIFNLIMHLCAVKKDTMFQYGAVQLITFLSAGNFVLTTCAIDPNMQFVSNGSKHRSWLLNKLFTIRPISGYSGFPRDTFSPSFPLPKSLPYEKKFNLTGISNENLYGVIVEPRNEIEICNLNSLISSDEEILMKYAFWIIFTGKMTAKTKVAQKLREWFPKASINLSSVVGSDAKVADLKLEDFDQMFNLLHMELNDDFTYISELRNFYAHFRPTTENAKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYP9</accession>
    <name>A0A183HYP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12611</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039882">
        <property type="protein sequence ID" value="VDP11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYP9"/>
    <dbReference type="WBParaSite" id="OFLC_0001261201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029717">
        <property type="entry name" value="FAM193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109">
        <property type="entry name" value="AGAP004327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109:SF3">
        <property type="entry name" value="PROTEIN FAM193B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2142" mass="242449" checksum="86207813F2C19935" modified="2016-09-07" version="1">MSEVLSANYPEGSMKENTHKCIRKVIIDGNDNNLVDELVEDLSDSVYSNDQRHEKHEPKNSVSRGRHRLATFSLRSVIDGGVQSKFNITCLLCKRRFAYNDARSTFLAYYICDDCMESEKGHAEELEAALVNNDKARPVSISCTGEDLDAYDHCKCQNCVRRQLMNEERRKETEVLQRCWHDLRQNIRQMFRDGLNANMTSSKGKRFDVDKIKRNVTILAEKDPHQLYKRLESIGHEYVMNLKSDDLWQILVAPQVVPALIQVSLALWSFRLRESITPRLQLYEAGASEEQMELERAKLFIKTLLDRFSCQQETAKNMSSLLAVLDEGYLSQFGISWKVVNHHIFDRVIYQDDLLLNYLPSLENALKCKLIVHDDENEEDRRQRACTEVNRTDIPQGALELAQSFRVFHKLMVTSREIFKKASANIVLYSEQQKVINHIKRKTKGELLDEDLEFFKSQRKMVHNCILRKDQYYQWHADLTAVGNLTDLIDDGCDVSMCESYHFSDNSDSEADDVNLSKRLHELIEEGPPTSVCIDENGEVLPCVRCKRCTLRYCSCDECRISHIITCGLLIDNEDISNLIWPVSDCYDRSDDKDSDSEQSQQKKSSLPNIKRLPNRNLRFQTARALFTVHDHHSVPKKETAWGDWQVPYSYSNDIDCLSHCLCERKGMHSDFGSLNNRQYMVGLLENEIRHIAALQIQIFDLLFNLYDGEEEYTIDRIDSPGLPNSNKHQEIVKEAFELMTKGHRVESSSNCEFESNDVPGTLSVIGDEKKTSVIGGSDNKHGVKNSFLVRKSNLCSEEKSGFTISSVSNINVKRFKIKKAGNNVARDSDGAESDYETPSASFPGSNECMDSCHLSGPDRLLLKEMTRRHYAVLTKDNAVSDLALELFGRKTMEKPQMVRKAGLTPPVSRLIRKSKLVSDKNDANSGSISAVKSLSASARERLLSEVKSMDKKVRERNLLRLVQSYEDERWTTRSEDYKSRLIESMKECLSKDWAKEDETNDLKIIIKDEKYGSLVICFRGFTDLYFSYGSTRKTVNQNSTAKTSHQEKKNDREMIYIPEARTMVSFATTSPSSSANKKAKSSPRKVEQDDLAQLWSKQTLAAAIAKQLTDQRTIMDISKAFNVEKQKTAQTVSCKMGNHLDAMSNSTTAIDFSVNLGEFDINNVPEELRRLHEEKLKKLLKQAVGLKQNKTSMSTKVDCKYDDGKRIKSDFGDSKEELFGYQTDNFDDLTDDDDEGTDEEWSDCEAPDEQHPYRHHSCDNKANFSCITKIVFQHYFQAKNKRTASGTGRDGRHGHCDCCYCEMFGHSVTESIKSGRAQIRERLRMKLKRRSVQEHSGTDAKNQGEKLTYAATNQESKKSLAVVPDAPIEEILDYINEKDIVAAQAAASKAAKRARQKLRKQEEKERQERERKLKEEQKKAVEAELLKKKKEQQAAQEVRKEKQSKPEAKKKKMDRVRGRKQKDGRDRKKEIGLQLSESQEVEVRKEPVLEFEYWNDPKCDPKFKQLGSTKEQSGTSKIGRMRAQNKEESKKSEDIPKRSELEKRESEKENASSKREGIRADSVVNKNDNKSSENESNGFISETTFPIHCVTKFLKTENCESQEADLDIQPTMKLPSDKESDVPSTDVTVSEASTVLSEVELVSQPPELKCSITELLPPKMPPLLQSLSEISVMLPAGLNNANITQRLPFPILQVPPPSQANTLGFGTYQGGVGYYTHFGGQPQVYLINGLNQCVVSSSNQNAPLLSSESADFAQESVLRPLRTSQGFEARTCQIGINDTLHISGQYSVPSSVNTPSTDMLQRTGPVSPIPVFDTKSFQTTTNFSSFDFQKLPLYVSEPSSLSPLSSSASSSSLKPSLYGPPFSLRDFDFVSFKGTKTAEMPSLGVMSLPLQNDLCHNNGTAQIFLDTSTAANGFTLPDSACCPKQYIPDIAIPVGNMISDNLPVPTQDLLYCTSLEQDIIAAKIQKSSPCMNAQFLVTHQNDSTMGNISNAAQLNKVETDGALLGSSQFTAAIRSKRSEACKTFLSSSSPLADYDSETRKLAAFAKEDEIFRNQNPMIFEPGDPRIAVAIAEMKFDPHEAFKPRPNSELEFLDPLELEVEHFKRVLWEEEQLTRPRVPLRELRKIDPENEPDAVFHFAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYZ2</accession>
    <name>A0A183HYZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C3HC4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12704</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039909">
        <property type="protein sequence ID" value="VDP11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYZ2"/>
    <dbReference type="WBParaSite" id="OFLC_0001270501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001270501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001270501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001270501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11107" checksum="2506BB0CDAF3FDBE" modified="2016-09-07" version="1">MSENNKSTPCANGCHSATDAHVFMNVIDAKSSDSDNELPTMPTMQECDGTCGGIYLADQLTIFPCLHVLCGMCLNECSLVGQLHFRIYSTIPVHELFLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYZ3</accession>
    <name>A0A183HYZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12705</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039910">
        <property type="protein sequence ID" value="VDP11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYZ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001270601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001270601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001270601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001270601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10203" checksum="AD89AD44ED1B881D" modified="2016-09-07" version="1">MKATLMLLNGKPVVDRITQQTDDEKRIIFDMKPLLLRYLQSNWGNNPACSTSSIRSTRSERKRTSDLSSNTTDESENTSGARVKTRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZN8</accession>
    <name>A0A183HZN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMMECR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039988">
        <property type="protein sequence ID" value="VDP12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZN8"/>
    <dbReference type="STRING" id="387005.A0A183HZN8"/>
    <dbReference type="WBParaSite" id="OFLC_0001295101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001295101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001295101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001295101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20900" checksum="F16456371974EB20" modified="2016-09-07" version="1">MCAPSRPFSFQRSVIIWKKERNRPNSQSPNKFDIFVFLALTRNSQRRAAKANLKKRHREHYHITRRLHQHPVLRSTITVSTTCQLEKKPGPISGRIASLHMTAYCFDVLYAALRNHQAPKIPPTIPNEKFPLFVTWKKGYERRLRGCIGTFTNLVLHKGLHEYAIIRMHRSDGTLSFGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I053</accession>
    <name>A0A183I053_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040051">
        <property type="protein sequence ID" value="VDP12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I053"/>
    <dbReference type="STRING" id="387005.A0A183I053"/>
    <dbReference type="WBParaSite" id="OFLC_0001311601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001311601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001311601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001311601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64103" checksum="C9C86533A9A18B94" modified="2016-09-07" version="1">GSRSTSPASRFPVRVPPRSQISSRVKVQVDESEDHASVSSDSFRFETMELATALSCCGSSSTTEKKEGLKALFTIISSDKQINVMDLKKIVERLNPLIGEGAHKLLQPLADTVIALVRRYHEELNDWLNLLIPKLIAKCSTDVLPSNLEKYRIMMEAVRTSFDPEKQLHAVCKFIRDPVRNNVNVKIKHGLLMYLHDLMRGMDSAPSMNQSEVRQAVSKIFQWIDDPKNVCLISISEKVVCDMFHLNASDFTSMLATFPNDLKDRLQTIVRKNSFCLSTSNGINANEAHAGILETTAQINDFVDRRASLPVSSPRSSPQLTNGAVRSPYNGVLLRRSSREDQNGSLSGYILDPQGFANDPEQQEELITKIGEELSFHNQRSEERQRAMSVLSQITRDNLFSLWDKHFKMIFLLLIETLKDNDENIRRMAFAQASRFNEFAEMALMRVLDACTDESKLVVTAAEECGGVLATHVSSATCRRVLLAIIKSDVGEPKIHIAIKLLTKVIESLSAAELELILDEVAPPIVDTYNYVSSSIRKESVVCLVAMIMLVGDELMAPYLSELNKGKVNFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I074</accession>
    <name>A0A183I074_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13136</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040058">
        <property type="protein sequence ID" value="VDP12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I074"/>
    <dbReference type="STRING" id="387005.A0A183I074"/>
    <dbReference type="WBParaSite" id="OFLC_0001313701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001313701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001313701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="10">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001313701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25673" checksum="EBF1C91B36E3DFE4" modified="2016-09-07" version="1">MKGSANEAGAVSVMKTTRTPIELSSWPDFIEERIALFDKLMAKYHEEIAAKKPEKIKITLPNGKELEGKSWLTTPLMIAEQISQGLADSAVVAKVNGEVWDLDRPLECDATLQILKFDDDEGKQVFWHSSAHIMGEAMERYCGGHLCYGPPISEGFYYDMWKEDKQPFERLVVSKEDLLQMFKYNKFKVRIIEEKITTPFTTVYRCGPLIDLCRGPHVRHTGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0D3</accession>
    <name>A0A183I0D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS13195</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040084">
        <property type="protein sequence ID" value="VDP13144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0D3"/>
    <dbReference type="STRING" id="387005.A0A183I0D3"/>
    <dbReference type="WBParaSite" id="OFLC_0001319601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001319601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001319601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="8">
        <location>
            <begin position="90"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="545"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="338"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP13144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001319601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="619" mass="71770" checksum="A31092ADC11A7C0B" modified="2016-09-07" version="1">MRYWKYSTYWSILFPGRNIVNGTNSLVLLPCNLSTTMNVLELFGFDFSTTLSETQKLTKDYERSNLLFITRLVLRVFLDESMRSRHRIIDVEIRSLTDLFVMLEKVLWHVQKTMIALRTPDSELWSCLGKVANINTDMNESYQCIDRLDKITTPLLRIRAFLRLAVMQKKLGNYFENLYCIHSEDKFENILVYLINFKTDDENVFRDFYEPWALIRHDECIGLSGALMALSVLDCNLVLDQAELEKQPVTVELAAYVHLPNISIHSNSEKESDLVNARSLELALDQKNYLEQRNHYLESKVVELKTKMEEISLSTLNNLTDATTEDVSTVTNEHIVTMEALEKEKAELAQLASEKEDSIQILRQQLADTKKVNVDLYEKIRVVEGKYRQLEKDMMSANKRYNHEREQQQQIISVLNERNSVREMDLEHETGTSEMLKKELADKTDEYMQTLNVLEKKQQELAVANDRLGKLQRQTSELNEKLKQLPVIKQELEELTASYKYKSEKLEECEKALEELGGHLSESKLKVVELKEELLPLSEAEWEKDGSVLNCKGCNLQFSMSKRKHHCRNCGSIFCNSCTDARVKLPSSAKPVRVCLHCYNLLRSRHNSSLEENSSLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0H6</accession>
    <name>A0A183I0H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13238</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040103">
        <property type="protein sequence ID" value="VDP13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0H6"/>
    <dbReference type="STRING" id="387005.A0A183I0H6"/>
    <dbReference type="WBParaSite" id="OFLC_0001323901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001323901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001323901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001323901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17753" checksum="65ACE4758B5856A5" modified="2016-09-07" version="1">MGILPRRKVGNIWCKEIIEFPVVQLSAKNFEEVGRFHRYVRPTERPILTSFCTDLTGIVQETVANQETLPEVLGAFNKWLIDSNLINSDNSMKSRFTFVTCGDWDLGVLLPNEANYFKKWINLKKAFCKWKGYFAKSLTVMLRDLELNHVVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0K4</accession>
    <name>A0A183I0K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13266</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040117">
        <property type="protein sequence ID" value="VDP13313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0K4"/>
    <dbReference type="STRING" id="387005.A0A183I0K4"/>
    <dbReference type="WBParaSite" id="OFLC_0001326701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001326701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001326701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001326701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48669" checksum="E52181197AC42F6C" modified="2016-09-07" version="1">MDSQGRKLLVVDNGTGFVKCGYAGTNFPAHIFPSVVGRPLVRSSQKVGNIEIKVHIFTSSFEALFLTKTSLVLLLNERIGNIVGFQDLMVGEECTQLRQMLECSYPMENGIVRNWDDMGHVWDYTFGPEKMDIDPKDCKLLLTEPPLNPSGNREKLFQVMFEQYGFNSLYVAVQAVLTLYHQGLLTGVVVDSGEGVTHICPVYEGYALNHLTRRLDIAGRDITRYLIKLLLLRGYAFNHTADFETVRLLKEKLCYVAYDVEKEQRLALETTVLTESYTLPDGRVIRVGGERFEAPEILFQPHLINVERSGLSELLFGVIQSADIDTRLEFYKHIVLSGGTTMYPGLQSRLERELKQLYLDRVLRGNTEAFQKFKIRIEAPPRRQHMVFLGGAVLANIMRDRDADFWISKEEYEEGGLERCLRKLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I109</accession>
    <name>A0A183I109_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13421</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040190">
        <property type="protein sequence ID" value="VDP13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I109"/>
    <dbReference type="STRING" id="387005.A0A183I109"/>
    <dbReference type="WBParaSite" id="OFLC_0001342201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001342201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001342201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001342201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12222" checksum="A7FD04C222CCC2D6" modified="2016-09-07" version="1">MPTIRQDWTIFDARVHQRLLKMAANSASSSITSLETSPVGLSGYRSAVTGTTGSNSGMATVTTHASAAAASSAFSASPYFTGHFGNSYQPAPDFSSYVANAPSAAGWYSTHDPRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I160</accession>
    <name>A0A183I160_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MMS1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13472</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040217">
        <property type="protein sequence ID" value="VDP13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I160"/>
    <dbReference type="WBParaSite" id="OFLC_0001347301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001347301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001347301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001347301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31401" checksum="CE5A3AB510CC13BD" modified="2016-09-07" version="1">MAAVVGTRFTSITVPTDGDETTNLTFFKQKCHSLYESNVIASIFDDDGSYMESEQNESGNYKRLESKNIECGMERKERTVLSDLNADGDLLAIAIGEDISIFSFDCGTRFIVTVHLGDDISPVAMKFMPVVNLIAVVTNCGNVIFLSIGSNRIIHQVKLMENMRIQSASICCDLQFDDAQMCIVLESGEIYSFFFPNYSKYFHREQEIEIEISNRQKGMANMIWEQFDKHYPGRDSAIINHLNALLLLSSEQNARITLLDLSAEILDKALDEFYSSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1B3</accession>
    <name>A0A183I1B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13525</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040245">
        <property type="protein sequence ID" value="VDP13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1B3"/>
    <dbReference type="STRING" id="387005.A0A183I1B3"/>
    <dbReference type="WBParaSite" id="OFLC_0001352601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001352601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001352601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="7">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001352601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="654" mass="72087" checksum="3AE9FFDD67EF5F73" modified="2016-09-07" version="1">MILLFTESETDCGTTVQDWSPTEKCPFCDGLRISTDDCSEKDSMRIELESESAVSDSEYYGAVCSNQAKIEQGATNSSPESTGHLESSGCSQSRLSYMHPFSNLSTPSVLPVMTPFVPLPEIANQLFCQSLLQWSTSNLLLQQINSHRSPENLHNPISEQYLLAPKRNTLMHGKENGDAETNHLIQHIIPSVSAKLDSVKRAAQMCINNDLPVLFGGLSKSSFNNESLVERPTAICKEVNDNGGTTEEDQPLDLSSRRALQAVTQCAVSSAQNSRDGGQLRALINVISDKSSNSLPKDEKNNSLIGHTKNVAGTRTVYTSMSKRNYTQADLDAAVQDIRCGRLGTRRASVVYGIPRSTLRNKIYKLDAADDQRTNGTGGKKKRMNCIGAAITPDRVPSPLITTVPYPNDANARSTEIIIPPTQTFMTIDGVPPVRKIIQEIGPNNKPHFTNQESINANDETIVENKKSLWSPFTHQQISEPKNVHKEEKKTARSPANNTESQPDWKKSRPKRGQYRKYKKDALDEAVRSVRRGEMSVHRAGSFYGSSPATDSLRQSTLASATTNDVNMAASTMGTVGVLPPAASAVPSHFQKLPNLLLHNTEETEKACAAHMARQTARNTVESTVNFYCSVRVRRTQDYYYQARAISECTNERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2X6</accession>
    <name>A0A183I2X6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle checkpoint control protein RAD9A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA repair exonuclease rad9 homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14088</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'-&gt;5' double stranded DNA exonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040589">
        <property type="protein sequence ID" value="VDP15456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2X6"/>
    <dbReference type="STRING" id="387005.A0A183I2X6"/>
    <dbReference type="WBParaSite" id="OFLC_0001409601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001409601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001409601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000005">
        <property type="entry name" value="Cell cycle checkpoint control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001409601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41853" checksum="8E482F75878FE95A" modified="2016-09-07" version="1">MELPEEEADADVTAGASFTLHGNFKIFARAILALNRIGNELYMEPNNFGLVLRSLSCSKSAFGTFMFSRSFFSECDVLRLDSNAYNVCRIPMKCALSAFKCVKNSEKAVLSCQLYLNPRADSMLIQLTHTYDVIRNHKIPFFECTTMFRTIVDKANLNNCFVIQARLLLEMFNRMHHNTDEILIDAKTEEISFRNYITHEQDRDMVMKTEGKIPVAEFKRYSVQRPAEITVNLKELKAIVNFADVHQSLVSIYFDQPGIPIVIALEDDVNYTAEVILATAVDDPASCDMNPEVLVEIVHVPTDEGQLKRKHSQSSSNPHLSRNLVEDCVVTRKRITVVPTIKSSNVKEPFSGMGNMDFVIGPPYATSSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I330</accession>
    <name>A0A183I330_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14142</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040620">
        <property type="protein sequence ID" value="VDP15644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I330"/>
    <dbReference type="WBParaSite" id="OFLC_0001415001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001415001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001415001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001415001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45142" checksum="08CA3EB6B8BB2D96" modified="2016-09-07" version="1">MKKTAKGMECAEFQVATVKTDSEEKDQDRKLTERGKLLQMQKNWLEARKKIASLEAQVNMHRLREEALVCEMVELRKSQEVNQTKFDEERREWLRDMRVIQESKTQNADNDKAEIDLLKAEIAELKSSLDDAERTRLFLLEDNGKIKQQKAKLRCDYNELKREHNKLLSSQQTGSTSVRLCNLLYITRKSQVLCDRSGTENIPNRSNQNGLRGGNNFGTAVLGLSETYSICISPVPITQSDNSNVTSSEADSKPTTARSVNMQSIVMNNVNTEEKKLIEELTEKLKHSDEKNKELREALHTVDEQCEKLVRSFQELKLRYEEMERNLASNALVSSTALQGSSQCGQSDLGTGHSSAEKDHKFLSQKPLDDGNPASNSIKRKYASCLTAFGKRSKNDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3Q0</accession>
    <name>A0A183I3Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pancreatic secretory granule membrane major glycoprotein GP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14362</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040793">
        <property type="protein sequence ID" value="VDP16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3Q0"/>
    <dbReference type="STRING" id="387005.A0A183I3Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0001437001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001437001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001437001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055472">
        <property type="entry name" value="DUF7044"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF9">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23071">
        <property type="entry name" value="DUF7044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7044" evidence="1">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001437001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17039" checksum="CB2AE43C63197067" modified="2016-09-07" version="1">MYRRTDKCPSKWNGTFHMNGHTTLLYFNETWMDTLGHCIASSSNHQNYIFRLELSNGICYRCVAIFNVHPNVLQYKQSECIKQYESSNDDIDAVCRSAFHGDTPMKTLFRSDAKSEQCPFELPFNFTYAIQDGSCTSRVSSVTVCPGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3T5</accession>
    <name>A0A183I3T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14397</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040825">
        <property type="protein sequence ID" value="VDP16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3T5"/>
    <dbReference type="STRING" id="387005.A0A183I3T5"/>
    <dbReference type="WBParaSite" id="OFLC_0001440501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001440501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001440501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001440501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26204" checksum="66A2EA6816919AE4" modified="2016-09-07" version="1">MCSVEEKNDEEISYSKVVKGNLHGDNDFVIIACRIQLVRFCGAVVIEDKRNVAMNLSNFMDVIRIQESGNFLGTSGSASMSISIASSSPCSRLTPITTKFISVVTDMDQDWDQYCGSATDLDSCLTMLIVKIFHGTLFLKSASLENVIFSVYDDGDNSMIFLNKTLDNHRFQDGETALHCAAARGHLECVQSLLDAGASADAIDQNGQTALHLALKRSHIDIALLLITKGCKLDIQDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Y7</accession>
    <name>A0A183I4Y7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14799</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01041213">
        <property type="protein sequence ID" value="VDP18857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Y7"/>
    <dbReference type="STRING" id="387005.A0A183I4Y7"/>
    <dbReference type="WBParaSite" id="OFLC_0001481001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001481001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001481001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP18857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001481001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52342" checksum="8118ADB14AD39172" modified="2016-09-07" version="1">MTIHVSSSKDQSKNSELLVCLKQFRNEWFRYCCAAVFTIKFLLIPCYHSTDFEVHRNWMAITHALPICSWYYDDTSQWTLDYPPFFAFFEYFLSQVASKIIPSALILQKGAYFSTELLYFQRFSVIATDIFYILSCVFLTKSFFGRCKNDSSIEKNSLAAEIFLITNASLVMIDNIHFQYNGILTSILLISLGWIMRNSFLRGPNIKLNSAVIFTGPFIYSCGLDILKQIWRRLFPFERGLTHAYWAPNLWAFYNFADWYFYQVLKLTKRLPSNVQSPTYISGLVQEFKHSILPPVSPFGTLLMTLALLLPILSLIRTRHVKNFPLLLTLSAFAFFLAGFHVHEKAIILITVPYTVLASSDHRFLPSFIMLSVVANVSLFPLFFTPFENMLKISITLCYMFLSISIMLFLCPERSLHFLKKLYLYGLLIVQVYCLVLHQVGDFLFICRTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6T4</accession>
    <name>A0A183I6T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FGF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15447</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042159">
        <property type="protein sequence ID" value="VDP21915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6T4"/>
    <dbReference type="STRING" id="387005.A0A183I6T4"/>
    <dbReference type="WBParaSite" id="OFLC_0001545701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001545701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001545701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="3">
        <location>
            <begin position="31"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP21915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001545701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23863" checksum="54E8785461DF3979" modified="2016-09-07" version="1">MAWLHTSQGIRSSRPAEMASHSAGRKETEEAMKIMHDSSGRPSQITWGVSSINFEYDRLNRIILISAIAQGASYLERKFFYQKENQLIPSLVQMPSGEKYRWRTDHIGGITFLKTPNGIVHHFMQYAIFDRVCRQRSVSFSNASYVACMDDDGQLLDYRTPDRLHSLTVKRDMYGRVVQITSDAEDIFFRYEGKNRNSQVCFYILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7G5</accession>
    <name>A0A183I7G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15677</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042603">
        <property type="protein sequence ID" value="VDP23182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7G5"/>
    <dbReference type="STRING" id="387005.A0A183I7G5"/>
    <dbReference type="WBParaSite" id="OFLC_0001569001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001569001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001569001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001569001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10320" checksum="8E235B692E3FFBF4" modified="2016-09-07" version="1">MYSGRNGRRRGLLRPITANGGGSMFRILPLFGFLMGLLFFFIYYIYQVQNVELYNIRNQIELERNRQIKVKLENIGWYRLICHVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I836</accession>
    <name>A0A183I836_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15898</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043177">
        <property type="protein sequence ID" value="VDP24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I836"/>
    <dbReference type="STRING" id="387005.A0A183I836"/>
    <dbReference type="WBParaSite" id="OFLC_0001591101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001591101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001591101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001591101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18872" checksum="97FFF9653FD3448F" modified="2016-09-07" version="1">MMKMIGEHPNITALIGFRQIDSCWEQFMEYVDGGNLFDYINQNYIKKNRLLEVEKAQSFFNDLLSAVEHIHSLKIVHMDIKLENCLITKNGIVKLTDFDEARYFIPNVKIPFPIYFTESYAAPETFTKRYRPNYADIWACGIFLYFLLQQHFPWKVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8I0</accession>
    <name>A0A183I8I0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transferred entry: 7.2.2.9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS16042</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043749">
        <property type="protein sequence ID" value="VDP26385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8I0"/>
    <dbReference type="STRING" id="387005.A0A183I8I0"/>
    <dbReference type="WBParaSite" id="OFLC_0001605501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001605501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001605501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060003">
        <property type="term" value="P:copper ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP26385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001605501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21474" checksum="22370C63956AE3E7" modified="2016-09-07" version="1">MAHKDKRSKMEVILKRAFEAAITVLAIACPCSLGLATPTAVMVGTGIGAINGILIKGGEPLEMAHKITTVVMDKTGTITKGRPWVVVVHTLISENRLSLPKLFAAIGSAESNSEHPIANSITSFVKELLNTKEWAAVRRFHASAGNGIACEVQKIDDMLLGTSKEKESQIGPVIKLNSGDVTLIKKEHYGICNECLYILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U6I4</accession>
    <name>A0A3P7U6I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000847">
        <property type="protein sequence ID" value="VDO30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H2H9"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="137" mass="15087" checksum="2F2F5C7F9E00FC40" modified="2026-01-28" version="1">MSNMSNSSGSELAWRLKAIGDVEQKIAELIKHAQTCVNELSKEKQATCISISFQISKSKMEEASSAFKKCLNSIESDLNAQMQYLSHVCVGTAHQGSTFSSQQNISLAEQTLVSLKDRLSAIQHIYLPVMTDMAAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XX58</accession>
    <name>A0A3P7XX58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017645">
        <property type="protein sequence ID" value="VDO79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XX58"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="168" mass="18430" checksum="60FC6E1086198341" modified="2019-02-13" version="1" fragment="single">MSGQQLGSRFQYTTRPENVGERQTVYRTIPSAGTKKGLSAPTVQRQKMFQIATGYGNSPEAQQQIYATTSHAGRTLIMSQGDSSQLGETSQIQMIRPQIQTAGISMRQDARSKINQRTPGRLYVTTAAGDRTYLMPQSQVRMMPSGQRITPKRTAGAIHAKTIAGQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AXC8</accession>
    <name>A0A3P8AXC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012899">
        <property type="protein sequence ID" value="VDO65145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AXC8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="135" mass="15975" checksum="E48D49BACF7336C3" modified="2019-02-13" version="1">MRESEKSLKAELLKAEEKLQTEKERGRRIITELEQYRKTEESARESRGRVQRELDALKVLSESLSNENKSLRQEKFNLAERCEELLKKRNSLTDDVASLTSDVESLKEMNFDLHQKVICWKHLLKCIIPFTFTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AYU8</accession>
    <name>A0A3P8AYU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040618">
        <property type="protein sequence ID" value="VDP15621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AYU8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="116" mass="13548" checksum="A8F48AE120BE3EAB" modified="2019-02-13" version="1">MRTIFQNLSNSNFSIISKFQITPYGQCHCRFSKLRDKIFRRQINHCQFDGIRNFTSIDGLTQHNYQQSVVYIQNAKSNADIVDIEGEEKMILKSSIIADWNLIVETKYVNCIKPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY13</accession>
    <name>A0A183GY13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000029">
        <property type="protein sequence ID" value="VDO24625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY13"/>
    <dbReference type="WBParaSite" id="OFLC_0000012201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000012201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000012201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000012201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16238" checksum="D4C9A729350F5621" modified="2016-09-07" version="1">MKELRGRADTESDDGISLVGVIVVVTTDTPFFLSLPPPYPLTLSLVYIQWSLLPSFIHSTNICIIPMFRKIASIRSQLRVLELNGAHDKLDEICAPSTDMALSFDRYPLYSVAPCLVKSKVTLHKGRTLVDLWSSHHELFLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY35</accession>
    <name>A0A183GY35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000035">
        <property type="protein sequence ID" value="VDO24715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY35"/>
    <dbReference type="STRING" id="387005.A0A183GY35"/>
    <dbReference type="WBParaSite" id="OFLC_0000014401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000014401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000014401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000014401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22593" checksum="6BA2CDC7C26AEE1F" modified="2016-09-07" version="1">MESNELDEIMKWEANIQPPTIDELRTYTKNECPTGRMRIANFKKMFGSYFPPCLDDEYVLRLFTAFANGKEEMTFKVYFIFQDLMESLALLYLPTPEANAVWTIRMIKGCDVETITEADLLAFVKSVFRLAVFEKSKENKTSDCGFQMIDTTLQNVAIHRSHGTFKALDKHGNGYICKSDFVNFFQVHHFHAILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYQ5</accession>
    <name>A0A183GYQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FCP1 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS365</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000113">
        <property type="protein sequence ID" value="VDO25536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000036401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000036401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000036401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000036401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18417" checksum="86AA2754F78D6208" modified="2016-09-07" version="1">MMERQPSVRYVLSVCYRKHWRKHRVAQDRTLIINFLPTPRYGSDRHERLFQRLTSRDVLEKFACLRHANFMIIDLNILLVCRNGGKHHLPDSALLNSKGVGNHVHFIMAKQDMGFLTTCEINNGDDGDDDGANERIQKHICILCYKEILRECAKVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYV0</accession>
    <name>A0A183GYV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein polybromo-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS410</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000131">
        <property type="protein sequence ID" value="VDO25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYV0"/>
    <dbReference type="STRING" id="387005.A0A183GYV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000040901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000040901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000040901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000040901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23391" checksum="B1F3745593B32258" modified="2016-09-07" version="1">MDMPSSSRSIGKRGIKNDGQVSRGAKRRCFKKDQLKEDVRHLVENEDSDEEKSCREWKEDEDIPLPKNLCDDVARIYEDVMSRYRNMIDAEGLKLYHKMLREEPRKKYVTTSRVKPLNLKPMPEQPTYFTLRSAMNAVLQKCPSKCIEAVMSTPRMQYWTLTECNILVSLTLISLLVFVPWRWSLWYSSYFLIYFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZB9</accession>
    <name>A0A183GZB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patched family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000201">
        <property type="protein sequence ID" value="VDO26292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZB9"/>
    <dbReference type="STRING" id="387005.A0A183GZB9"/>
    <dbReference type="WBParaSite" id="OFLC_0000057801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000057801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000057801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF185">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000057801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37667" checksum="6BFCE267737EA81C" modified="2016-09-07" version="1">MKFQGMKQLEDFNERFENLFIKSFYYHGLLVGRYPERFLIGSLLLTVICTTGLPAVKINLDLYKLFVPLDAPVREEFERSTIFNKMPLGLSDRTQTNRIKRQIDIFNDPVRIDVIRFYAIHEENANLLESRTLRRLYRYTNEIMNTTVEYNGEIYRFEDFCQKDPEEEKCSNELNVWLKHAEILFQDGKANSNPNLQLSYPVMYLFNRPKDIGQVIYGVNVTGRKREINSAKVLTVHWYIHFESSPEKEKAYLAFRKELDKFWLSKRNESKIKFIPHNDKAMNDELLMIIETALPFAGVASLQLMLFVIISNYSRDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZX3</accession>
    <name>A0A183GZX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS783</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000304">
        <property type="protein sequence ID" value="VDO27055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZX3"/>
    <dbReference type="STRING" id="387005.A0A183GZX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000078201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000078201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000078201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000078201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39125" checksum="8277AB4128E125F4" modified="2016-09-07" version="1">MDISDWAKPEVVQLLEQYIQEPAGSIEELQKLIQQIAGKNLTVSKLRHHLQQFQKETAVYKQHSKDVIFNENETSTNEIKQCDNSRGAAAENRVSVEVTQTDITNFEQGMAGEITTSKQEKISNSREHMDHVDNAEAVSIRTRTFRKKKRVSARRKQELRMLRSYRSRRRKKMKNESSITTIIDRKKNSKATDDERVKQEAEEQEMNSLVKAAGTTVPSTELTPLILSKPRVILRRTTLIRTRCIISATKPTIPVSDSAVVTSYSQQIPDWNVHENDDVTEPTIPDSNTAAVTSFSQGIFGWNVPGNHGNDAVTSFWQPLTYSSIGLESDPTGRAVTTSRSAIYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H046</accession>
    <name>A0A183H046_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS856</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000344">
        <property type="protein sequence ID" value="VDO27334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H046"/>
    <dbReference type="WBParaSite" id="OFLC_0000085501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000085501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000085501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000085501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40720" checksum="DD85A5F3C72A3DEB" modified="2016-09-07" version="1">MSETCRISDSASSQLDDIYLSCGSDQYTVGVRIIEDSSETFSAWQLLCCSGKSVKIRIHDCIDTKFLNEHRRSSTFFTGTQIIRKWQAVLDDNDLRWWLQLCPVDIMRNNRIRNNKSSRVRRQIPWQWTLNRFDSIKDDPIFMKEDRLNDTSSRSSGSMNHAELFPKTPLQFGNEQKTKLIANRNTNTTLATEMNLPQSSTLKSSTNTINSTTLSTVKEDVAIDYYDHYDENFDKSNHESRQGILGGVSDFLQNIQDGLSIAQAALPSHKKQIYEITTTTTTEGPAFLLSRDEDSLTIGMKHDSERGINNARLKLQRFGPKPHRPDASQAVSTSFKLGSPGAIQQMFQFFGLCKKHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0L3</accession>
    <name>A0A183H0L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caskin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1023</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000433">
        <property type="protein sequence ID" value="VDO27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0L3"/>
    <dbReference type="STRING" id="387005.A0A183H0L3"/>
    <dbReference type="WBParaSite" id="OFLC_0000102201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000102201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000102201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09497">
        <property type="entry name" value="SAM_caskin1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09498">
        <property type="entry name" value="SAM_caskin1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000071">
        <property type="entry name" value="Caskin, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035497">
        <property type="entry name" value="Caskin1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035498">
        <property type="entry name" value="Caskin1/2_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000102201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="68655" checksum="772961ADC9306ABA" modified="2016-09-07" version="1">MQSGMNLEMECQKNVITASSSSSSNLKQRSFSVSRQNPDDLVCDLCHRNSAGSSSSHDSSSGFESMKSGSSHGCSIVGTQGAIICGSSRGLLPHSSQSRLSMQSCSSGDASLIMNNIANLFDDSATEHVHGDNLLNISRLSFSDMMLKGVQVVKFDPPYILQESEILALWLGSLGYPEYLTAFLTQGYDLTTIARITPEDLTALGITHPTHRKLLISEIHKWRITDTWPTLVPSGKLRDWLPLIGLPEYVALFEGQGYCTVAEIQNFTWDDFEDIGIKKLGHLKRLGLAIKKMKDHEFGRNQPKNDLQQLVTVAMHHNKVGAQASFLLEIGTAIYDDLRSHLEMPPSSAATSTFYPTNLDSLYSNYSTVRKQRSHLCEASSTESHARKQADQVYPHYQSLVNEMVPYHLQRSDQQSLECGLNKQKTSSLQMNLYSLSQILSDESLQKHSIIQQQSVFPTKILSTANNSISSDSEDYPPPPAPLACEGSIRLLKSAFNESAMTKTTGSDITNDSNFERPYNEIGSFSLNGQLSYAKDNCDAVKSRNGLLLRHKFNEESANSSFSLPNTACQKLHNSSYSTSARNGDILNDIGSMLQNLTDELDAMLLPSQSIQYSPCRQIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Z6</accession>
    <name>A0A183H0Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1152</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000503">
        <property type="protein sequence ID" value="VDO28443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Z6"/>
    <dbReference type="WBParaSite" id="OFLC_0000115501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000115501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000115501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000115501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9857" checksum="1F144B8AC1275628" modified="2016-09-07" version="1">MKPRIKCYLIMKSALNGTLSCQHYATDTNSQNCHKIEERKSKNAKKNWVIFSALWDRMKKKKIWQKTSHSPLCSLFASNHQFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Q3</accession>
    <name>A0A183H1Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PDZ/DHR/GLGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1413</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000658">
        <property type="protein sequence ID" value="VDO29443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Q3"/>
    <dbReference type="STRING" id="387005.A0A183H1Q3"/>
    <dbReference type="WBParaSite" id="OFLC_0000141201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000141201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000141201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="412"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="538"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO29443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000141201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="765" mass="84222" checksum="37882114F30F730C" modified="2016-09-07" version="1">MSTTTKSAAIGPTGIVHCQQNSNYVTPSEHYVFVHRVECLRDGGILDPDDQLFDVFDENNDQILAIYDEPSHVVMDSAPTSSSRFANNGTISSSSSATAKTAASVESTLDGKLNIISSSNDGDIVEITNIAVAPTDGLQVIPDNTHILQQKPSSSSVITGSESFSSSTHFDQKSSDVSGTRRIYHSALKNVSGSPKSKYRVTISPDVDHLSSQESSTFSKESPMTRSFTRKSRLTGNFFDAKERLEEKLANDIKSCAIKADMKSSKLIPLMEAANRGQTVIVFSDSTINMQLGIEISPVYDPANNMRLQAVEIRQIDDEGRVGNDGRLRVGDHIVEINQRPVYQMSISRARAYLHEIQAVAHPSLTIDRSIETFTSDIISHRSQSSTNSLQKRPILSALQQANTTVLGTTFPVEIVKRSGGFGFTITSRETGKGERLFYIGTVKADGAAVNKLRAGDRLLEINGEKTTELTQNDLVERLKKLDVGDSVNLLISRLGNQENEKQNSTTVKSNYDDGKCCHQKRASEETEQYGEEILTLKIALNETGSAGLGISLKARAIMKPDGTRHDCGIFVKKVLHGGAAYKDGRLQLNDQLIGIEDIDLRRMTKNSEASDAITRCLKNLGPNASNVSLKVARKVELRQSNDSPNIRNDGSRTKFEVHLVIDTITCQLSSNVANGEDRCYVFNHSFKFILVYIARNTNEDLDSISSDRQKCMSEDEISHVDISAFSRKNPARKSISEKRHMGTGNDANNTMLFQKIKHNRQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H249</accession>
    <name>A0A183H249_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1559</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000759">
        <property type="protein sequence ID" value="VDO29977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H249"/>
    <dbReference type="STRING" id="387005.A0A183H249"/>
    <dbReference type="WBParaSite" id="OFLC_0000155801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000155801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000155801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="1">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000155801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="865" mass="99638" checksum="696EF8BF2CC80994" modified="2016-09-07" version="1">MILNSLYDHLLQAFIADNPHEQHNLMRVILSGSHLAHLLTPYFTPHCIPPTELFNLYTSLSKAIRDPMTSSAALTLLSQLDIKNTGDRLPPHQFSQLMPVAFENLISISDTSLPLYDVCAKHFIHSVFHRFPSNFIDGLKLSLAACDTKSTPLCIFDEIIEKLGASKKDVMDTKSQYIIDTMTAIVASETVAVQFKKSRNELSTRFYNIWANYLSKVLHLVHFFLYSIASLSFDSEQSIEKLKSELRQVFERCVQVFGPLLEPFGSGLPPWNPTDTDSAAIVLDYFVSLMEQLHQLYDAYFPSGSDNLITLFWRYYVEKLAFFTYGGSHMHQIIESRFINIPWHLFWPSLYDLTSMDKIMVDGASESAPLIAQIVVRIPWLPLIQYQEQEPSDAHRAFYSLLFSLLASCISRPSNYAICRASLPKLMNSLLPFPWHLIDVERLNAVSSRIASTFSSTVLTEPSDVTSAFFELYRRVCFLTFSIDSVSAAEICQKQSFYVRTQLALMLRNANDRAWLSRFYEDQIKVVHNIISSTELPSENQTFLSRELISFWSDISDNKFLEVFSSILLQWLDKNPNSSIVLLLMNTTISSLKINQLPCGLQIIEKCIATYFERMGVCEWNVVLKWTILPDHCRQILFTSPSSDNTVLFLPLCANVFIMKQLMSLVSMKQLETASLQQENALLRTLLDYITILKPRYVTNEAAFLLLMEKLQKLLLRQYNYSVEQGSQFLMQYLEWLERVYSDDKSSSFFSLIGFSKKQPYSIRMRYICHLMNLYISQQMIAPNQPPRNAVNAPVLNYRIQSFKELCTHKQYTQFQATSQLAQPYFTEVQKYHIVHMNELFAHVVRSIYNEKYLEEMLANAGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2F6</accession>
    <name>A0A183H2F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1664</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000830">
        <property type="protein sequence ID" value="VDO30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2F6"/>
    <dbReference type="STRING" id="387005.A0A183H2F6"/>
    <dbReference type="WBParaSite" id="OFLC_0000166501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000166501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000166501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000166501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43335" checksum="E86CA8E1B88097B2" modified="2016-09-07" version="1">FLINSIVLSTSFGLENISVCESKKTQHAHSDDDDLEDALHEMTAFTGKCVSSSKSLTKGVINVKRLDNITRGHRFGKKPMRALQFHPNRKVLMCAGENGLLSLFEIGMPETEETFLQNVQFKAFPITNAFFTADGSKIIVGSKKKESLFCYDLLNGKVMQMRAPYEMTKMNMGHFSLSSDGKYIAVLAYNEVHILTATIKIRFQSSEYVGALTASTKIACVKFFPNDSSTVFALGENGQVFMWNIRKPKEQQTFYDEGSVRGTVIRISENGQYIACGSNTGIVNLYDSADVLKNSFPKPIKVFDNLTTSIDCMTFNTDSQILSVSSSIKNNSIRLMHIGSRTVYTNFPSRDMSLGKVTVTDFSPKSAYMGVGDDRGFLSLFRLSHFTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3U9</accession>
    <name>A0A183H3U9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001183">
        <property type="protein sequence ID" value="VDO32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3U9"/>
    <dbReference type="STRING" id="387005.A0A183H3U9"/>
    <dbReference type="WBParaSite" id="OFLC_0000215801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000215801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000215801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000215801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6538" checksum="43FFB9BF3721AEE3" modified="2016-09-07" version="1">MELSEVIERPRVDNVFLRKGPRQPQSGSLALIGHHMIFSPSSGPTNSPNEKEHSNELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H513</accession>
    <name>A0A183H513_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitinyl hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2573</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001506">
        <property type="protein sequence ID" value="VDO33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H513"/>
    <dbReference type="STRING" id="387005.A0A183H513"/>
    <dbReference type="WBParaSite" id="OFLC_0000257201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000257201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000257201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000257201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7608" checksum="C1729BD60B04D1B1" modified="2016-09-07" version="1">MNVTGFSHQVGGHFGIFTCGGHICKPLNSKELAFYKEIGDRFAPFTAHCCGLSLISFYLPLLMYYNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H584</accession>
    <name>A0A183H584_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS2645</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001558">
        <property type="protein sequence ID" value="VDO33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H584"/>
    <dbReference type="STRING" id="387005.A0A183H584"/>
    <dbReference type="WBParaSite" id="OFLC_0000264301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000264301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000264301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="304"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000264301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="48478" checksum="BAA2D820F8A11A94" modified="2016-09-07" version="1">MDFKNKLIGAIDQSTSSTRLIIYQLNPRKIIASHQIELRQIFPRAGWVEIDPAEIFAATLKCIIECCDSIKVTGYDITDIKAIGICNQRETTILWDGKSGKPLYNAICWLDDRTTDLVHSFIEKTSNKSENQFKEITGLPIFSYFSALKIRWLLNNVDNVKDALKRGTLMFGTVDSWLIYKFTGRHITDVTNASRTLLMSIKTLNWSEELCNFFGIPMNILPEIHSSAEIYALMNIGPLKGVPISGCLGDQQAAMFGECCFNPGETKCTYGTGTFMLANIGDDPVISGNGLLTTVAYQDACEIETAAASVSGSGGVVFVPCFTGLYTPYWDSSARGIICGLVQTTKREHIIRAVIEAVCFQTVEMVEAIRTDVSHNKEIKILKVDGGLTKSSLFLQLLSDILGIDVIKASNIEASSWGAAVVAAIGAKIIRFNYNRLSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5J9</accession>
    <name>A0A183H5J9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2759</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001663">
        <property type="protein sequence ID" value="VDO34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5J9"/>
    <dbReference type="STRING" id="387005.A0A183H5J9"/>
    <dbReference type="WBParaSite" id="OFLC_0000275801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000275801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000275801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="105"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000275801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41393" checksum="B49736BE2BE67773" modified="2016-09-07" version="1">MNELARCIPSQLPSSKSFNHNQQYTFQNDNADSDLSSNDTAYFNNLNLKRSVTFEEDDTVRDTTLTCASQILPSITKRNGIPQALRPLAEARLHSPAKDYAKVKFLSICPCEELTLNQINGENDMADVVVLKNESVKNVAYKIKITSPEKFRVRPSTGTIAPGTTEFIRVYLQNGIKISPLINSSKILMLCLSYEYFYLNITTLTKKKSKNHPPITQLFQFDQCKSITEFRNSVPREKLLLMAVETSEESSANFGNIWKNSSEEAKIEHKLKCRLPIGNDIVTSTVELMDPITEGSGNDRGSAVSKIYENVGNTNGLQTKDHYDFDSVHHCASIAILHLAASILYINFEYSKRFLLQIHISFKQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5T4</accession>
    <name>A0A183H5T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2845</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001741">
        <property type="protein sequence ID" value="VDO34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5T4"/>
    <dbReference type="STRING" id="387005.A0A183H5T4"/>
    <dbReference type="WBParaSite" id="OFLC_0000284401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000284401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000284401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000284401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="49441" checksum="D4F4C55DBBC3A1D2" modified="2016-09-07" version="1">MSTTVVAADSNQLNFNPSWMRPVSMPVSAGGGNNSCNRTEPLYAAENPTVDYPIADPIFVKNRYGREDLLALLSKDVHPPDDLDKCQFYVSAAQKPIVLTPLSDTETRLQHNINSSKAMSLLSHADRATIASGGMIGGPNIPLQLRVGQENRSFSPSWISASGGGNSGFGRGSLQFGRATYGGSYRGRGLTQTNSTNPSEPAAVGRISANRNNRTGGSGFGRGNSTIQPFNARAQGLYDPRDPRDRPRQRLRSTSDDTSNPSFGGTIDELPAPLNSGWTQVGRAAAPWNKRLHVNMNSTTQQSTANTEFTSQSQLPEWMSDDQERGDSSNLEETGSFDDSGQFQASAIARRMATSLGLIRNPASNIPVDIPERKLDRQKLHQEEEKSALASSVPVTVPNTWSTISNNLNHEQPQSNRIAKHFVEVCNFWKNNRVLKIVGPFKSSYYKAINEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5U4</accession>
    <name>A0A183H5U4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="5">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2853</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01001745">
        <property type="protein sequence ID" value="VDO34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5U4"/>
    <dbReference type="STRING" id="387005.A0A183H5U4"/>
    <dbReference type="WBParaSite" id="OFLC_0000285401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000285401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000285401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000285401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23780" checksum="4FC322A3039E5998" modified="2016-09-07" version="1">MNLFTPWFAQIHCGNENPTNQSDFPTNSLSMNISRIVERDSDSDADNCDELEGIFSKMNPISKLKRKTVKKGSLERKPLLSGRTQTLIGDESGSPSDRQNRSNNENYGSVGNAQFANIIGDAIHAIREGVYPERIRQGSSGSYFVKNCEREIIGVFKPKNEEPYGQLNPRWMKWIHRIFFPCCFGRSCLLPNQVCFKKNFLFHAVKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H672</accession>
    <name>A0A183H672_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS2984</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01001864">
        <property type="protein sequence ID" value="VDO34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H672"/>
    <dbReference type="STRING" id="387005.A0A183H672"/>
    <dbReference type="WBParaSite" id="OFLC_0000298201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000298201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000298201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="135"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000298201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47899" checksum="27CE58169A43CB3B" modified="2016-09-07" version="1">SGHNSGVLHAGIYYAPGSLKAKLCVRGIDLAYEYCDKHKVPYKKIGKLIVAVEPIEVPRLENLFERAQKNGCKSIEMIDGSEIKNYAPFCRVIQDIFLCFNVMIKRIQELSISDVSKFFFSKNKDCVTLHAQGLKALWSPYTGIIDWGLVTKSYAQDFKNRGGVVYTKYPLKTLLFVGESSKENVVNNYPVIIESEPSLSKIRCKYVITCCGLQSDHIAKLSGGTSDPKIVPFRGEYLLLTSESKKKLVTTNVYPVPDPRLPFLGVHFTPRMNGDVWLGPNAVLAYKREGYKYSQISLVDLYDTLTYRGTRKLIVKFFGYGMKELYRGIWIRAQVKQLQRFMPDLSISDVTRGPAGVRAQALDSNGNLVDDFIFDYGQGELSQYVLHVRNAPSPGATSSLAIAEMIYEKASIRFGLKQQVSELSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6V6</accession>
    <name>A0A183H6V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIH_assoc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3218</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002084">
        <property type="protein sequence ID" value="VDO35707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6V6"/>
    <dbReference type="STRING" id="387005.A0A183H6V6"/>
    <dbReference type="WBParaSite" id="OFLC_0000321701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000321701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000321701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF102">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RyR/IP3R Homology associated" evidence="1">
        <location>
            <begin position="245"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000321701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48036" checksum="37C2D8BB38290EA2" modified="2016-09-07" version="1">MQKFYTQEEFYVDKGSKLVGVLIHAEEVRIRLLKRYFGDDAVCSMKTSEQTTKLEGNEYEFGHELKPIKELPLNDVQCKLNNAGASDLIIDLIMKEPSHEIFLMTIQLSKALLYEGNYEVQMSFYNRLKEQNTSEPFFNALKTKLQVAQNRLKSDMMACSDSRQRHSVSNSVSGRCNVNSLIASVMNSPSPDDSTCTLKELKSVDINSVDLTVSLSAVPDGYFPGLFDPDVNLNFWDDKKTLLSQEVALIEPILRFLQLLCENHNLVLQNFLRCQGSRQNHNLVDETLMFLDVICGSTKGCLGVFGEIGEHNSSLITQTLVTLTEFCQGPCYENQSAASKLLLAVMESRRDADNAERVLMNMYHMDTGAKQLVQAIKVAYGMSELNEFATSKIRKDYETGCLLTKSKPKISRPDIAVQDGFITSYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H732</accession>
    <name>A0A183H732_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PhoLip_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3294</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002164">
        <property type="protein sequence ID" value="VDO36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H732"/>
    <dbReference type="STRING" id="387005.A0A183H732"/>
    <dbReference type="WBParaSite" id="OFLC_0000329301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000329301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000329301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000329301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9493" checksum="C0C71A0D81F2E4A8" modified="2016-09-07" version="1">MLGNSCYTVWPILPIGMDIYGAASMMFSSLSFWLAFIFIPIITLSTDFIIRTVQRTFAPTPIETACFHEQFKVQNGDRYCELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H779</accession>
    <name>A0A183H779_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3341</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002205">
        <property type="protein sequence ID" value="VDO36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H779"/>
    <dbReference type="WBParaSite" id="OFLC_0000334001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000334001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000334001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000334001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10179" checksum="B260BFD5F97130D4" modified="2016-09-07" version="1">MILNSLICYLFELLRLYYFYILPYSNTKNSNTIEYHIPRNQENTIDCHVGDDIDNNDENFDDAKAENNFASKNSASELANKKGDSFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7A6</accession>
    <name>A0A183H7A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3368</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002228">
        <property type="protein sequence ID" value="VDO36259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7A6"/>
    <dbReference type="STRING" id="387005.A0A183H7A6"/>
    <dbReference type="WBParaSite" id="OFLC_0000336701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000336701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000336701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF53">
        <property type="entry name" value="VON WILLEBRAND FACTOR TYPE A DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="210"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO36259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000336701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56617" checksum="0F90F5ABDC5FDA5B" modified="2016-09-07" version="1">CIRGSDKPLDLILIIDSSESVSHLFDEQIRFAVERIVQNINIHPDAVRFALITYSGQAHIHFKFNDQQIHNNSAVIQYLNTLKSIKGTTSTHIALHQAYNLLTDTDSEARQGVKKMIIILTDGHSQRSPVDMALRLKNKNVETFAVTLTPAPYADESELLSMTQNTDHVFTPDNLEDFESKFLPFIGFGCIGVNLGPNPKPRIRGATDVICDKSSVTFTVRTQRPMIGLMYAQQYHDDTKCKTDGSSREISITFYEGTCGLIKTPNIQLDGYVFNITVILQFHPVIITRADQGLSVSCFHQRSVSQEEIGRSSIKKLSDIECTYRLHRFAPDQCVPLDAKVGESLYHKWECDSPPNYHYLVHDCFVKSETKNTLIIDSSGCEIDPYFLETPDYSKFFENPKKYPVYVFKEMSVFKFPGDGNIAFKCQMSLCDMESNDPCKAMIPPRCLHNATLRLKREIEKPAKIKPGFATTLNVETRTVNVLENESTRPSTPISGPQSASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8L7</accession>
    <name>A0A183H8L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3828</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002692">
        <property type="protein sequence ID" value="VDO37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8L7"/>
    <dbReference type="STRING" id="387005.A0A183H8L7"/>
    <dbReference type="WBParaSite" id="OFLC_0000382801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000382801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000382801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000382801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40913" checksum="22A4B6B79AFBF883" modified="2016-09-07" version="1">MSHNIKNFKHEVWNKISSDVMRRGNFAKYTQNPLLRRKLFYTYGSTLVECSPTDLEWGIGLHINEPDALSPSKWRGKNKLGQILTEIREELLLKPEYAQEVSDIVSILENFDSFSRQFFLPPKPLIQQYICPSSIENDHDKKRNLPFSTKIGRKTDGNCLQQFVNLQRNASNTKIENSSSTAHREDYSQPDRSTRKRNYHMPSYNRDFRWHSDDSKDRKKSSSRLEKKRNASKNSKSHYGMQSRSSRDHNNSESDRESSRFLKRQRRIEVTIDSDRLAACRRYRDCGISLSGSEESSNSMRCTDVEMIKKAFEDPFKSLLERLRNKKCGMWKQYAAKSNRKTNGTIPSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8U7</accession>
    <name>A0A183H8U7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3907</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01002776">
        <property type="protein sequence ID" value="VDO38181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8U7"/>
    <dbReference type="STRING" id="387005.A0A183H8U7"/>
    <dbReference type="WBParaSite" id="OFLC_0000390801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000390801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000390801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO38181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000390801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40236" checksum="BAEE16436DA4E1B7" modified="2016-09-07" version="1">MIFLGFGPSFLLYLNSVPTARRAMREDRSKAMALFGNHDYLLHFWNELTPEERKQLVDQFTSYNMPELDKAFKESGRPVKIESLEPIDKDHYTVAGDIDENIMNEYWNTGLEAIAEGQVAAVVLAGGQATRLGSTEPKGTLSLGFTDYDVTDSLFALQAARISRLQDLARAAFPNSNPRIWWIVMTSSTTADGTLRHLRDVLPTAGLDAEQLVVLLQRSLPCYDINGGLFLSSKSSFKVSPNGNGGLYECLEAHRISSMNNDIKYFHVYGVDNVLCRVADPHFIGYCIKKNIDCAAKVIEKIDPFERVGVICQTPNGVQVVEYSDLPPELASLRDDSGRLKFHSGNIASHFFTCDFVHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8V5</accession>
    <name>A0A183H8V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyco_transf_7C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3915</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002786">
        <property type="protein sequence ID" value="VDO38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8V5"/>
    <dbReference type="STRING" id="387005.A0A183H8V5"/>
    <dbReference type="WBParaSite" id="OFLC_0000391601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000391601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000391601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000391601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15022" checksum="74804C25AE64B1E9" modified="2016-09-07" version="1">MNFYLTNFIFDMLNKVPKIANHFPSSVFIKELFNKVDDRINYDYLDIPRHIGIYYCSIDFTDTFVMIISVSRYAFKNAEIVGDVLAIFMDHFNIVNEFSNEFWGWGGGDEADEMGKIAYFKVEHDMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H924</accession>
    <name>A0A183H924_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KASH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3986</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002862">
        <property type="protein sequence ID" value="VDO38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H924"/>
    <dbReference type="STRING" id="387005.A0A183H924"/>
    <dbReference type="WBParaSite" id="OFLC_0000398501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000398501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000398501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057134">
        <property type="entry name" value="Spectrin_Anc-1_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524:SF5">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24611">
        <property type="entry name" value="Spectrin_Anc-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="7">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="8">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000398501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53350" checksum="7D6C3EEE4DC15EEF" modified="2016-09-07" version="1">MKNHEDFDEKRTQLLALETICTECEALYSELENLIKDGQKLLDDSEALPESYNITSDALATLIETAIDLRINKPQIEQLPEPIFAQLWETVDKAKDVQTQLMHRVYVWEQFVKERDSAVVELNDIHKQIREIEGRGVRRIDKMLDDLEALKMLYLRWSFLANLPSRLLSLSSQLHPLACVQREGKAFAEEACELEKKIEDLLDSMSAEFRIREEIVHSLLVISDELVDIKNAFDDQNISTHLQKELQQQLEGIRAHLKILDEDITKYNSNRIFLDEEEDITTKHNFEKLEEIEEKLKLVELTDTEEEYDIDAAAEVLAAVYPDDHPRDVLREQGIPYDDELYDLSPSSATSDDDDNNKFMTSSGDEILLQNDEGENVVEAPTPSDIALSPIPDDPSPGHIHYERQRIRWRRILRTALPLQAMLVLLLGAACLVPHCDNESCCQLLNNFARSFDPSLEFLNGSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9L9</accession>
    <name>A0A183H9L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo repeat-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4181</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003078">
        <property type="protein sequence ID" value="VDO39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9L9"/>
    <dbReference type="STRING" id="387005.A0A183H9L9"/>
    <dbReference type="WBParaSite" id="OFLC_0000418001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000418001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000418001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000418001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17909" checksum="A0800ED97AA965ED" modified="2016-09-07" version="1">MWENLYTFCQNRHTEALHLVLDAMQRHLEDSTLQIAGSASLFYIIRKVSMNRDTKRMVVTALLDGMDAHMEEQVMVRNCCLSLCQFEIPLEILFDYGRVARLLVAVLQHHNSDHLTQRIVVFLLNSMACHVEGEQKVQVGNIGAIEVSISGIFFVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA69</accession>
    <name>A0A183HA69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Animal hem peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4381</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003297">
        <property type="protein sequence ID" value="VDO39807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA69"/>
    <dbReference type="STRING" id="387005.A0A183HA69"/>
    <dbReference type="WBParaSite" id="OFLC_0000438001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000438001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000438001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF85">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000438001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33916" checksum="FA0A47BC56B888D2" modified="2016-09-07" version="1">MKLASQLQQLNPHWDGDRLFMETRKIVGAEIQAITYREFLPKILGSTFAKTIGQYHGYDPNIDPTLVNEFNSAAFRFGHGMIQEIYPRLDQNFNNISLGSFSFFEGTLHNDRLIFGGGIDPILRGMMILPVRRSQRLTTAVTENLFGNTDLGTINIQRGRDHGLPSYTRFRQFCGLSTATTFDHVCFFYQFDLKYKVDLFVGGLLEDPVQEGFVGPTFACIIGPQFQRTRDGDRFYYENPGIFTHAQLKEIRKISFSRLLCDNGDNINHVPREAFRIGELTSCTQIPQMDLTKWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAR9</accession>
    <name>A0A183HAR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TDP43_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4581</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003543">
        <property type="protein sequence ID" value="VDO40397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAR9"/>
    <dbReference type="STRING" id="387005.A0A183HAR9"/>
    <dbReference type="WBParaSite" id="OFLC_0000458001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000458001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000458001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAR DNA-binding protein 43 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000458001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16918" checksum="02F41D246469F2FD" modified="2016-09-07" version="1">MDGEKICSSDESLKSVCAPDEWVVVANAIGSKAVEIPLCPSHGVLHVRTVRNIFKDATGLKYRNPDTGLDRVLSMNHDETCFLAPTGGWKNKMFIVVRPVKFVRLQGNTKKQVKRSLANKPKATTDMDPNSNGKMRSVLANSKANSVSAALESAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB08</accession>
    <name>A0A183HB08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4669</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003661">
        <property type="protein sequence ID" value="VDO40683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB08"/>
    <dbReference type="STRING" id="387005.A0A183HB08"/>
    <dbReference type="WBParaSite" id="OFLC_0000466901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000466901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000466901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000466901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42120" checksum="C0E28DC837FC4863" modified="2016-09-07" version="1">MVEHELQLQEQSEMAARKASKSQDDLAKLSHFGTMRMLHSLPTACEYGRFGADCEYRCIDCKNGGKCRRNKSGCECASGYTGTICEDQCPEGTWGLNCKNACECDGQICNRITGECDCPNGAKCDDSCPAARKQLCTFDISSGRTSEGIHSILSLSCLYFSLTNGNTGFYGPSCNLPCQMTCSNGRCDRKYGYCSCPAGYYGEKCDQICPRFNYGRNCRHVCNCEKEYSEGCEPKSGKCICKSGFYGPFCKRRCPVGFYGQSCTKKCECAKNQECDSATGDCIRKCRPGYTGDDCQNPCPAGTYGYNCVQKCACETGASQVCHHVTGTCTCRPVCPSGLYGPNCQHECVCRNNGTCNSKDGSCICPAGYYGAACSEGISFFIITAICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB73</accession>
    <name>A0A183HB73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MTTase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4735</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003746">
        <property type="protein sequence ID" value="VDO40898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB73"/>
    <dbReference type="STRING" id="387005.A0A183HB73"/>
    <dbReference type="WBParaSite" id="OFLC_0000473401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000473401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000473401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="225"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO40898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000473401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41393" checksum="21EAAC2C850AD315" modified="2016-09-07" version="1">MFCTKSRYFLICNFHMKHNILRQLHSSLAISQVKSLAQKRPLKFNRDGPGLDYFINMANSKHLSKVMPKIEEMDESLSATGFHGDGLKVKFITYGCQMNINDVELVRSLLLSTGYVETNDVIESDIVLLMTCSIREGAENKVWDELKMLRKIRRKRGVVGVLGCMAERVRHNLLTCTQNVDVVAGPDSYRDLPRLLAIARCGSMAINVQLSLEETYADIVPVRQNKSSKTAFVSIMRGCDNMCTYCVVPYTRGRERSRPMNSILDEIKGLSDEGVKQVTLLGQNVNSYRDLSEISFSSAYLTEPGIAPGFRTKYKPKKGGYTFLTLLDKVSQIDPEMRIRFTSPHPKDFPLEVFFQNICYIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBR4</accession>
    <name>A0A183HBR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4926</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003991">
        <property type="protein sequence ID" value="VDO41471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBR4"/>
    <dbReference type="STRING" id="387005.A0A183HBR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000492501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000492501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000492501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="4">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO41471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000492501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25794" checksum="C35E844144FC5EA1" modified="2016-09-07" version="1">METAFLTLTKTRDRMESLVEGLTECEQLQCDGTVGFGGSPDETGETRLDALVFDGLNHEMGAVGSLPNVKNAARVAYAVMKYTKHSILVGDHAADFAADMGFKRESLYTNSSYIAHQKWIKQNCQPNYRKNVLPNPNKFCGPYKPAIGKNKFKYSQSQINRRNHDTIGMIIIDFENNIAAGTSTNGANHKVPGRIGDSPLPGAGAYADNDIGGAVSTGDGDIMMRFLIEIFHNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDC8</accession>
    <name>A0A183HDC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5490</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004749">
        <property type="protein sequence ID" value="VDO43328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDC8"/>
    <dbReference type="STRING" id="387005.A0A183HDC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000548901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000548901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000548901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000548901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16401" checksum="3E540F42CB3F6A2B" modified="2016-09-07" version="1">MHLFFPTVSPKILLLKALSSQSLFIRWKAPLLENHKGEILNYLIRWRPVLAKNETDRNEIPESDEDYEESSTGKGDKGGKRWLEMIQDAVLGNSAIISGLNAHTIYEVSVAAGNGMGYGPGSEPEQEQTDEDGWCCFVVFANLHACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE97</accession>
    <name>A0A183HE97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5809</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005196">
        <property type="protein sequence ID" value="VDO44421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE97"/>
    <dbReference type="STRING" id="387005.A0A183HE97"/>
    <dbReference type="WBParaSite" id="OFLC_0000580801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000580801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000580801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000580801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16441" checksum="8F4DC4CDD9BECDF6" modified="2016-09-07" version="1">MRRPRTLSIIALEELIQKRKQFIDRQKAYLAQLDLAIDNDQQREVVQLRRQQENLRAVLNPLRECDWPNRLQLERTELQKITASINEIEQKYDALTNEIKLRIDEERKLKCRIEAVKEELKQLENGTEIEILSNNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF09</accession>
    <name>A0A183HF09_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6068</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005563">
        <property type="protein sequence ID" value="VDO45289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF09"/>
    <dbReference type="STRING" id="387005.A0A183HF09"/>
    <dbReference type="WBParaSite" id="OFLC_0000607001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000607001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000607001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO45289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000607001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13744" checksum="D7728D14DE29172E" modified="2016-09-07" version="1">MEDQVGNESMDHNRFVVTIRLWIAFIVIFISVLAYILKKRLTRANTILIVGLCDSGKTMLFSKLINPKYNPETYTSLKENRCEDVSITNDKLVTLVDFPGSERLRKHLFGNYLQKVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF55</accession>
    <name>A0A183HF55_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">OFLC_LOCUS6116</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="16"/>
    <dbReference type="EMBL" id="UZAJ01005634">
        <property type="protein sequence ID" value="VDO45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF55"/>
    <dbReference type="STRING" id="387005.A0A183HF55"/>
    <dbReference type="WBParaSite" id="OFLC_0000611601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000611601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000611601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDO45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000611601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27019" checksum="C8F5D86767227A0C" modified="2016-09-07" version="1">MFYSHKKTNSPTQLLISLLGGAPFLLFLHLYAVNNCDASFIQFLQMLWSESNVVYQIFPSPFSSVAWKSLTFITLLQLIFHLVLPKDFVTIVNSMGERECHPVNSFQSCILVILLFIFGSALGFYKASIIYIHWVHILSLLNVVSIIIVLFLYIRQRSKDDDDNYSKYIRISEINHFLADIISDLFFGTDLTPMIYSVDLKHFITYRIARTLWPLYIISSVYYNCSFYGEINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFG8</accession>
    <name>A0A183HFG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005803">
        <property type="protein sequence ID" value="VDO45846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFG8"/>
    <dbReference type="STRING" id="387005.A0A183HFG8"/>
    <dbReference type="WBParaSite" id="OFLC_0000622901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000622901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000622901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.370">
        <property type="entry name" value="Caenorhabditis elegans Her-1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015313">
        <property type="entry name" value="Her-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043108">
        <property type="entry name" value="Her-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036341">
        <property type="entry name" value="Her-1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37979">
        <property type="entry name" value="PROTEIN HER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37979:SF1">
        <property type="entry name" value="PROTEIN HER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09232">
        <property type="entry name" value="Caenor_Her-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110014">
        <property type="entry name" value="Her-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000622901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18172" checksum="D7AA44F89DE0D654" modified="2016-09-07" version="1">NLFNLFLVVAQCCSKEFAECCAESVDFAKPLRCDGMKLETRIDVTLCIQKAMHEEYQSMLNLTDTVCCDVFADDDNDVKEHCLTECITVMQIPTLKKEEKLKRIEECRRINPLYKCFNRCLQWLHNSTEYEPLLFEQECSIKLKMVPGKIYIGPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG15</accession>
    <name>A0A183HG15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6426</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006105">
        <property type="protein sequence ID" value="VDO46504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG15"/>
    <dbReference type="STRING" id="387005.A0A183HG15"/>
    <dbReference type="WBParaSite" id="OFLC_0000642601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000642601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000642601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000642601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10098" checksum="4169B411FAE2193A" modified="2016-09-07" version="1">MMPFAATSSSVQRAKVPVFADKNYKICNRDPLIFKMRWTCELCGKKLSSKRSYDEHFNVHTNLRPFACKHCGYAAGNIHFQQWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGQ3</accession>
    <name>A0A183HGQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FtsJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6668</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006474">
        <property type="protein sequence ID" value="VDO47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGQ3"/>
    <dbReference type="STRING" id="387005.A0A183HGQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000666401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000666401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000666401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000666401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20623" checksum="C631D41EF272286D" modified="2016-09-07" version="1">MGKKTKIGKQRRDKYYHLAKEAGYRSRAAFKLLQINKRFEFLQKSRAVVDLCAAPGGWLQVAIQNMPVSSLCIGVDLVPIKPINRCITLQGDITTEKTRQMVRKELRGWEADCVLHDGAPNVGRNWVQDAFQQNCLTLSALRLATQILAKNGIFVTKIFRSSDYHHLISVFEKLFKQVSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHG8</accession>
    <name>A0A183HHG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Angiomotin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006907">
        <property type="protein sequence ID" value="VDO48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHG8"/>
    <dbReference type="STRING" id="387005.A0A183HHG8"/>
    <dbReference type="WBParaSite" id="OFLC_0000692901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000692901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000692901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000692901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13806" checksum="CCEB4017AF5F1E17" modified="2016-09-07" version="1">MEEEYRLLAERNHRSSGRLPGSNPNSGNGRIVSSTRPAVTVQPRQGLVAAVHSSLEQQTSSSGQIFGDHDPMDSSGSSTIGGGRYANMVRTAESRAAGITRVRPGAELGRAEHHGRGKLLIIVIFLKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH2</accession>
    <name>A0A183HHH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6934</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006912">
        <property type="protein sequence ID" value="VDO48536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH2"/>
    <dbReference type="STRING" id="387005.A0A183HHH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000693301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000693301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000693301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO48536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000693301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29769" checksum="7AB4924C8B53B74B" modified="2016-09-07" version="1">MLNRRRRHQTPTFLEGTPGRYLRRETPPSLPTCDGIIQGIQTGLQQLAHSSQNLQYTGYDVSSCRMGRNSVRTKSELSSQSFNESRTSNQYLSKKGLTPSLSIGNVVQHDGQAASTENGEQRMVSISLQSLPGHSISAPFAGENLAGGVPKEDLTLPPNWAVEVTPEGIRYYVDHNNRRTHWIHPLVKENLPLGWTKQFDAINGVTYHNKLDGRTQLEHPGLATPVNCVQNNSTAHLTQRAESTIEKLNIIGDGMLIIIISIVSIVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIR7</accession>
    <name>A0A183HIR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7382</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007681">
        <property type="protein sequence ID" value="VDO50738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000737801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000737801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000737801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000737801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15339" checksum="325E87BEFD3F91DF" modified="2016-09-07" version="1">MRRNEKQRHISSSSTSRTASILRAPSGTYTSLRNEKPPFPHQQPRSAYISNLETPILQSSAHTQATYVPPPPPIYAVESDYLESQKQHRNYPRQEIHGNVHSRQNYPTWKGPTTVLQQSFIPEHHPLSFHTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIR9</accession>
    <name>A0A183HIR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007678">
        <property type="protein sequence ID" value="VDO50719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIR9"/>
    <dbReference type="STRING" id="387005.A0A183HIR9"/>
    <dbReference type="WBParaSite" id="OFLC_0000738001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000738001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000738001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000738001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4707" checksum="51B845BA2058824C" modified="2016-09-07" version="1">MNYTEEQLRILVDAMVEQSRDSITTRLYDNYQYYSNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ93</accession>
    <name>A0A183HJ93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransf_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7554</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007969">
        <property type="protein sequence ID" value="VDO51518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ93"/>
    <dbReference type="STRING" id="387005.A0A183HJ93"/>
    <dbReference type="WBParaSite" id="OFLC_0000755401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000755401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000755401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO51518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000755401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8472" checksum="79A7E2CD88B590A5" modified="2016-09-07" version="1">MRPPIKYILDVTIAYPHKMPLSIFTLSFGTREPCDIGVYYKIYDASDVPFEDDEKLRDWLYSVYQYKDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJC4</accession>
    <name>A0A183HJC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7586</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008021">
        <property type="protein sequence ID" value="VDO51718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJC4"/>
    <dbReference type="STRING" id="387005.A0A183HJC4"/>
    <dbReference type="WBParaSite" id="OFLC_0000758501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000758501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000758501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000758501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22199" checksum="103812E46E82B954" modified="2016-09-07" version="1">LPQSGEDETSDDESSSEITSARNAHQKLKKSQARKRPRKHNISSDDDSGGTRPTRQSKVDGEKNRINYRDISSDEEVISYFIIIFLVINKNRFVINSDDVLEWDEGDKVGSSADHNTSGSETIEKVLRHRAGYPGATGASTTCYNVEDKGDPNIKLAGTDYEKILFLYCQRNMRKFMNFSINIYVNTYFFDKYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJT7</accession>
    <name>A0A183HJT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7749</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008287">
        <property type="protein sequence ID" value="VDO52399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJT7"/>
    <dbReference type="WBParaSite" id="OFLC_0000774801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000774801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000774801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000774801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="4752" checksum="8032ABC6D8A7D6DC" modified="2016-09-07" version="1">MSIRLFAPFLSSLVARHEFKVGRIVGDGGGGHECHRNAGEDRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV0</accession>
    <name>A0A183HJV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vps4_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7762</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008309">
        <property type="protein sequence ID" value="VDO52427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV0"/>
    <dbReference type="STRING" id="387005.A0A183HJV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000776101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8153" checksum="AEF5763BEE858B0E" modified="2016-09-07" version="1">MGDDRTSAPVRQLVEHFDHLLSNEEMKKMGEADDSLHDENLTVLDETQTTKPLNPPIAPENSLAFSDEVRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKE6</accession>
    <name>A0A183HKE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7956</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008661">
        <property type="protein sequence ID" value="VDO53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000795701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000795701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000795701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000795701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15111" checksum="1E0E744763FCF60F" modified="2016-09-07" version="1">QRCSPYVSELLPLILISPPTIAFDNISLFLTVVMGKSPGLLPITLYHSFLTESTKPKDISKDGYTQSHDKLHSPTTISMHCAAVATCGYMDLVSRQFGILSLKRDSMIDPCARRFRVLLTPKTGSFSTNSFERVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKY7</accession>
    <name>A0A183HKY7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS8146</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01008987">
        <property type="protein sequence ID" value="VDO54240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKY7"/>
    <dbReference type="STRING" id="387005.A0A183HKY7"/>
    <dbReference type="WBParaSite" id="OFLC_0000814801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000814801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000814801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO54240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000814801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17451" checksum="B47400710814119F" modified="2016-09-07" version="1">MGFAVNSLNTPCLADKDSIIISDQFNHASLILGSRMSGATVRVFKHDDMADLEKTIRDAIVYGNPKTKKPFNKILIIVEGIYSMEGSICNLPAIIALKKKYGAYIYLDEAHSIGALGPRGRGVVDYWGCDPHDVDILMGTFTKSFSAAGGYIAGDKVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL82</accession>
    <name>A0A183HL82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dilute domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009161">
        <property type="protein sequence ID" value="VDO54739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL82"/>
    <dbReference type="STRING" id="387005.A0A183HL82"/>
    <dbReference type="WBParaSite" id="OFLC_0000824301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000824301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000824301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000824301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28860" checksum="CECC81C82D260876" modified="2016-09-07" version="1">MDEIECSIILENMSYIFQILSLCLRPTSTNVQQCDIEHLNWLLCREFSMVVNEMQPKFSLGIAQDTKQLLQYCTTYNFMKNAEASLRQLLSGWLSFVNVLAIFSPVPFLALDVQYQYLSDALYLLLNYASDTYMDAKLSSAVSHCLLRLTASICVLLKSLKEEVAAFRTAITDVADVLIRFLIQPVETFVSEKAEYQVASHFGDDFPFDLTAFKIAQQDLLRNAFIKYGHELISLLSKDICDSPSGLKVSYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLD8</accession>
    <name>A0A183HLD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophospholipid acyltransferase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8300</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009262">
        <property type="protein sequence ID" value="VDO55019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLD8"/>
    <dbReference type="STRING" id="387005.A0A183HLD8"/>
    <dbReference type="WBParaSite" id="OFLC_0000829901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000829901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000829901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000829901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21752" checksum="F5A0FA772D1ECA52" modified="2016-09-07" version="1">MHFFSEYYINPSGRGLITSPSIGTLNRLERQKIVLWKKPFQTIHFAVREMLQLLAEFIVYLWQRKAHILSVLLVCAIGTYICHIPGIHQKYIHIWKIKLLRCLYWIGLGILSSVGLGTGLHTFILYLVSSYPHPLAIGPHIASVTMAAYECNSLDFPEPPYPERIQCPNVEGIMETAIVTVWSIMSKVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLM4</accession>
    <name>A0A183HLM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8384</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009430">
        <property type="protein sequence ID" value="VDO55404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLM4"/>
    <dbReference type="WBParaSite" id="OFLC_0000838501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000838501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000838501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000838501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10282" checksum="3861757513043202" modified="2016-09-07" version="1">MCLRNLPDNNEKISHLVHSMHYVSLHLTKYIKCLQSIVYPTFEIIMLVVIVLLAAVEAEILQMIANVRVIVTQASMTVRLLVSLYVVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLP6</accession>
    <name>A0A183HLP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8409</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009482">
        <property type="protein sequence ID" value="VDO55547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLP6"/>
    <dbReference type="WBParaSite" id="OFLC_0000840701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000840701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000840701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF5">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000840701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15431" checksum="FA156BF1D1D4334F" modified="2016-09-07" version="1">MNFIIFKIFTAQCGVAPEFSPCIPISQANLQFEQCCRNKLLPPSCLHLCKYDVTQDEISSVFATGFCGILHIVPIVQCASNGFDNSECCRYKQVIAKSAPQCEIFCRSGQEIIGLGLQHLICRKVMNELIACHLSGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM63</accession>
    <name>A0A183HM63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8585</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009836">
        <property type="protein sequence ID" value="VDO56376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM63"/>
    <dbReference type="STRING" id="387005.A0A183HM63"/>
    <dbReference type="WBParaSite" id="OFLC_0000857401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000857401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000857401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000857401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8927" checksum="D4C84D8A5213CC07" modified="2016-09-07" version="1">MMSFLDFYIFSVDAVSLLTIVACALRLPIYASCQPSLRAEMVHFAKTFCKRSRHVNHVRNEALVIKYNGIVSETLFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMB5</accession>
    <name>A0A183HMB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein grainyhead</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009913">
        <property type="protein sequence ID" value="VDO56584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMB5"/>
    <dbReference type="STRING" id="387005.A0A183HMB5"/>
    <dbReference type="WBParaSite" id="OFLC_0000862601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000862601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000862601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000862601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21101" checksum="CA1B8821E94C266F" modified="2016-09-07" version="1">MKLESFDSQSSVRATATMSSSQSQQQQQFHLDSSSVIKTAPPGRGQQQQHDFSPKSEPIDLAPLSQPSLQDLSKMQPIEQYYSMPSYSRVYTDYAAIGLAQGQTSIITAPSSATPLYYPTVFQGAVTAHEWQRPMEHYQQYQQQRATALQYPHQEVPQPQQQQQQRQQQQQQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMG3</accession>
    <name>A0A183HMG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010013">
        <property type="protein sequence ID" value="VDO56847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMG3"/>
    <dbReference type="WBParaSite" id="OFLC_0000867401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000867401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000867401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000867401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11129" checksum="896EC98C74B02A1D" modified="2016-09-07" version="1">MAFSKYFSDKPPPPPAGAPAAPAAAPAAGAAKPGEEKKEGEGEKKKSEPEKKEGEGGEGEKKDEEKKESDAEKKEEDKKEGEGEKKEEARKSEEKKEEKKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMX0</accession>
    <name>A0A183HMX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8832</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010313">
        <property type="protein sequence ID" value="VDO57629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMX0"/>
    <dbReference type="STRING" id="387005.A0A183HMX0"/>
    <dbReference type="WBParaSite" id="OFLC_0000883101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000883101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000883101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054106">
        <property type="entry name" value="CEP-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21907">
        <property type="entry name" value="SAM_CEP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47719">
        <property type="entry name" value="p53 tetramerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP-1 C-terminal SAM" evidence="1">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000883101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21545" checksum="5109E96C50B581C8" modified="2016-09-07" version="1">MRIFRLSLGNKRPAARHYPAVAEVVSVSSKNTPQQAWDDDDTIYSLQIRGRHLYKLLCSIVGNFELTRSLLKEKSQRSEKDKLMVSDSFGSLSQNTPIDSWLNTLELSKYKQLFADQSLYVIADLEGIINKTYLLSIGITEEDTTKMLNSYLAWFNIFNSQRLSSLSSEGSTIRVQRTRVNGSFRTPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNE1</accession>
    <name>A0A183HNE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010633">
        <property type="protein sequence ID" value="VDO58336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNE1"/>
    <dbReference type="WBParaSite" id="OFLC_0000900201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000900201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000900201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000900201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3730" checksum="0B1D76CA224642D7" modified="2016-09-07" version="1">MKNIQSNMNYQNDRIVSKFSRNFPLMVIRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPF3</accession>
    <name>A0A183HPF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011403">
        <property type="protein sequence ID" value="VDO60058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000936401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000936401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000936401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000936401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="4028" checksum="A7D9CB68543BA055" modified="2016-09-07" version="1">MVLVVGGWYYRKLGERKDQVEKKEETMVDVDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPU2</accession>
    <name>A0A183HPU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetratricopeptide repeat protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9506</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011714">
        <property type="protein sequence ID" value="VDO61087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPU2"/>
    <dbReference type="STRING" id="387005.A0A183HPU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000950301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000950301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000950301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO61087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000950301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29880" checksum="18F4B6830FF07097" modified="2016-09-07" version="1">MTEAYENALAELVRVVCHSEHTYLYTQALLHVMCEEETGMASAACAHISQVLRMEAHDREQDTSALHIALKQSHEEQITLNLLQAMHTMMSKQCLNPADITQLYQQYVSSNPPPVELIREHFFVDMLIDSLFAYEGIKVHVDHRPKYVYLLAYASSVGEQKMTTGRVQNRQELNMTRDSIERIVSLLEKTDDLMKEMKSLLCAIRLPVIAAGLLYYLRGNLLSDELISEPEPVHFVLLDQIATTHPNLQLNLNRRILFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRH3</accession>
    <name>A0A183HRH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10091</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013093">
        <property type="protein sequence ID" value="VDO65741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRH3"/>
    <dbReference type="STRING" id="387005.A0A183HRH3"/>
    <dbReference type="WBParaSite" id="OFLC_0001008401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001008401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001008401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="COR" evidence="2">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO65741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001008401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17496" checksum="307E8CD79ABE909F" modified="2016-09-07" version="1">MRSNDFRNIVQERMLKNYGRALRDDIEFNHACSFLHENGVILHYEDVTLRELYFLDPQWLCDILAHVITIREINPFARNGLMKIDDLQVLFKSLNLSNSAINLRSHIISLLQKFEVALCWQSRSLLIPSLLPDEYQLRGGYPGSKVMVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSV8</accession>
    <name>A0A183HSV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014225">
        <property type="protein sequence ID" value="VDO69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSV8"/>
    <dbReference type="WBParaSite" id="OFLC_0001057001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001057001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001057001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552642" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001057001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12414" checksum="EA0853380595EA4E" modified="2016-09-07" version="1">MNSCKIALFTCLLLAAIATTAAAAAVRAACLLVTCQEYGESLSSSSLVTSSNHKTIDNTQAAVFFPRKRKEKMNIDVIDGAVWCDDDAGGSARMDEPFPFNLSILREAGKANVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTZ7</accession>
    <name>A0A183HTZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E2F-associated phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10968</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015251">
        <property type="protein sequence ID" value="VDO72762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTZ7"/>
    <dbReference type="STRING" id="387005.A0A183HTZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001095901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001095901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001095901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO72762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001095901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22582" checksum="CF876E218EB83F78" modified="2016-09-07" version="1">FTDIKRNSRSSFDDDNNLLRKASNKVANASKNEAVEFYDSDEDEDNECWVRHHREQLKIVKPSNSSSSEDRRTKQEKDQDHETDAVLSCPACMSLLTRDCQRHELYHNQYRAIFVENCSVVEDEVLFLPQSGKNKQKARKNAAGIKPNTIVDPASITKFPKEDLFHPVRCNICATNVGVYDYEEIFHFFNVLTGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVC3</accession>
    <name>A0A183HVC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small, acid-soluble spore protein, alpha/beta type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016503">
        <property type="protein sequence ID" value="VDO76422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVC3"/>
    <dbReference type="WBParaSite" id="OFLC_0001143501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001143501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001143501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001143501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3944" checksum="091935E68B5BEE47" modified="2016-09-07" version="1">MNKLIKRRKNSNGSQKAKEMDQKVKQSLNRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVQ1</accession>
    <name>A0A183HVQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11566</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016833">
        <property type="protein sequence ID" value="VDO77377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001156301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001156301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001156301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001156301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7923" checksum="F7BD5F51E0EB8611" modified="2016-09-07" version="1">MDRRFARTNPNGTFIYDWLVGNDAPSPPYLPEKDGIVSKGKSGSIGQPVYELSWSFCLDQFNCDLFILPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVQ3</accession>
    <name>A0A183HVQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016832">
        <property type="protein sequence ID" value="VDO77373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVQ3"/>
    <dbReference type="STRING" id="387005.A0A183HVQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0001156501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001156501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001156501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001156501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7922" checksum="D329B6B84260F8FB" modified="2016-09-07" version="1">MHDDDSIDLLHWPNFLVRIPYLILTVSQMQDKFSLVRRRRRSDVSKTFDVKKTNGMNELNEWAIACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWK1</accession>
    <name>A0A183HWK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11862</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017691">
        <property type="protein sequence ID" value="VDO79878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWK1"/>
    <dbReference type="WBParaSite" id="OFLC_0001186301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001186301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001186301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001186301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7947" checksum="0BA075FA8C73A07B" modified="2016-09-07" version="1">MKVLSQIYHCMPLVITSYLFPVILLGLSLIFIPERLFAECNPMIKTRCQFAVDSSIQMVSFLVLEQRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWL6</accession>
    <name>A0A183HWL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS11877</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017732">
        <property type="protein sequence ID" value="VDO80051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWL6"/>
    <dbReference type="STRING" id="387005.A0A183HWL6"/>
    <dbReference type="WBParaSite" id="OFLC_0001187801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001187801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001187801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO80051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001187801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7202" checksum="DB5D1D25CA58FB45" modified="2016-09-07" version="1">MNSRVPLHASEATAARDALAKVIYNRLFTAIVNKITECMPFDESAFSIGVLDTAGFGIFYPFSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWZ8</accession>
    <name>A0A183HWZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018087">
        <property type="protein sequence ID" value="VDO81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWZ8"/>
    <dbReference type="STRING" id="387005.A0A183HWZ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001201001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001201001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001201001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001201001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9179" checksum="C79F30B36BD58AE6" modified="2016-09-07" version="1">TNVNEGLIIHGTILSLETNEPIGKLKLALIYGQLRLTIANLAEISFDNVTLDSDKSEFYGNHGFIVVVKCYNNMNLFDYVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX42</accession>
    <name>A0A183HX42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12065</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018238">
        <property type="protein sequence ID" value="VDO81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX42"/>
    <dbReference type="STRING" id="387005.A0A183HX42"/>
    <dbReference type="WBParaSite" id="OFLC_0001205401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001205401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001205401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001205401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="13040" checksum="C84A0ED87D7ED80F" modified="2016-09-07" version="1">MFRSLYLRNCHFFLLQAEREKTRVRQIRRRLDEMEEELIREQTKARNLQRMIDDLNAANDTLSRDNTSLRGQRRPVRDTLLGGRRVHIRNSSPHDDLDSIGTEGNRYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX90</accession>
    <name>A0A183HX90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12097</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018334">
        <property type="protein sequence ID" value="VDO81888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX90"/>
    <dbReference type="WBParaSite" id="OFLC_0001210201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001210201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001210201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001210201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7863" checksum="D4FE209684D200A9" modified="2016-09-07" version="1">MDDDKTIELPEKNEEEEEDDEEEGEDEEDEEVEVEDDEELEEECEEIEDESGNEQHEISIKVENEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXF1</accession>
    <name>A0A183HXF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12164</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018528">
        <property type="protein sequence ID" value="VDO82427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXF1"/>
    <dbReference type="STRING" id="387005.A0A183HXF1"/>
    <dbReference type="WBParaSite" id="OFLC_0001216301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001216301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001216301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001216301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13836" checksum="D86AFA30C2711AC2" modified="2016-09-07" version="1">MRETSLSSSFDPYSWRNFYFHVDREEATRLLCQPDSDLGTFLIRDSTAPGSYALSVREELSGDQQVRHYLIEPVEADNGKTNVKIADQFFVDIPALLNHFKMRILANVSLVCPLRKAAINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXY4</accession>
    <name>A0A183HXY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12343</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019074">
        <property type="protein sequence ID" value="VDO84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXY4"/>
    <dbReference type="STRING" id="387005.A0A183HXY4"/>
    <dbReference type="WBParaSite" id="OFLC_0001234701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001234701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001234701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001234701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9890" checksum="CA67F88E92828F02" modified="2016-09-07" version="1">MHETAERCAACSHFIMDMVLHALGKSYHPRCFRCEKCKTCLDGVPFALDPQGHVYCTEDYHRLFAPKCAACLKAIMPNKVSCKIFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYJ9</accession>
    <name>A0A183HYJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12561</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039867">
        <property type="protein sequence ID" value="VDP11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001256201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001256201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001256201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001256201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24062" checksum="BD1173EC7845E6A4" modified="2016-09-07" version="1">MKSAMSSASHAASSSTDSSSKSAATIRLRLLVSLLVLITMGSICQLCQIMSTGSGTSKIAGFLILFIAFFGHVWMSIHSCALTRARKAFFDESNVLETYQPRARTMGHLFSPEPPTPAPTVKFSETIDEEKEKRSTEENAAFHALRDSHYANMFEYAMKMQKEMQAMEKSGNQPGSASASSTETSPTQTSESTGQQPSAIDSSSSKQNSSKKSSSENKEMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ7</accession>
    <name>A0A183HYQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039884">
        <property type="protein sequence ID" value="VDP11754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001262001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001262001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001262001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001262001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10670" checksum="4A28EBD40343F3B8" modified="2016-09-07" version="1">MGINGTLKGFIDSQRFAENDECQPLTTCSIHKLFTLLNHKLLFYHCPSPSACQTVKEVREVNRRISYIILDGYASTNTSTKKGRDHEMIYLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYS7</accession>
    <name>A0A183HYS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TMEM132 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12639</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039890">
        <property type="protein sequence ID" value="VDP11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYS7"/>
    <dbReference type="STRING" id="387005.A0A183HYS7"/>
    <dbReference type="WBParaSite" id="OFLC_0001264001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001264001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001264001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20237">
        <property type="entry name" value="PFM_LIN24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369:SF6">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001264001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37655" checksum="EA5BD6B58BC17C49" modified="2016-09-07" version="1">MRETKFSGGSDRNEKLISDVMPATDPLNTTNLSGTGSKELVDLEVIVLNWAKQIFDVTKTKAEAKINKKFLQYNINWSHLFNESLEPIYTIGDVDVRNVRQSKDEQSLFKSTFTNTTEREQEYSFKTERSTRSAATVIIEKGVCRGVEMALKLKTPGEVVEANAGFSTELMVMNIGENRIEEELVWGVDSTVRVPPLCETVAELIILEDHQTRLVFFVLQLSLNCLHPICNVLFVSTNKTYSTKLYFYRKFSIESHMSGRIIVTVTNIKDNNSLVTIIEGKVADIIRGITNYSSLGFTIQNDVVSYTMKGTCKFKYGVEQKVKITEHPVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ72</accession>
    <name>A0A183HZ72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12784</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039931">
        <property type="protein sequence ID" value="VDP12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ72"/>
    <dbReference type="STRING" id="387005.A0A183HZ72"/>
    <dbReference type="WBParaSite" id="OFLC_0001278501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001278501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001278501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001278501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36180" checksum="15A6E9EA8960BDB1" modified="2016-09-07" version="1">MVCPLMRMDHARREKYALAACFLHAISAFFIFISEANHFLVLPKLMQSATQFIIHHSFLISLIPFMTTSLQLLMFAVHVYSIAAFAEQRQTYSRWSPWYLKLMIGFSTIQTDRNKINWLQEFFECCGVFGYEDWLPLTANNSLLESNLITNKKSKWSHCTGNGCYLPHSCCINSQLKCSSLILLQNFTKNEEVSKHRAKEWFYSEGCVDQINRSLNIGLLVAFSVINFIIQCITLVYSQIAFSSYYMVCCCDVEDATAVLPAWILPFPPPYPQTLVKVRFFFSLLRLYKFILYELHFYLLGIHLSNFMKGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I143</accession>
    <name>A0A183I143_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS13455</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040208">
        <property type="protein sequence ID" value="VDP13797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I143"/>
    <dbReference type="STRING" id="387005.A0A183I143"/>
    <dbReference type="WBParaSite" id="OFLC_0001345601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001345601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001345601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009231">
        <property type="entry name" value="Chloride_chnl_CLIC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552714" description="Chloride channel CLIC-like protein 1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP13797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001345601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43883" checksum="59609EE4B6977BBF" modified="2016-09-07" version="1">MLLLVVYMNLLVLGSHGENIDLDLHIDQKNWVDPNDPFASSSFCTKNTLDQLALCQANLKKCLKVEDHAENHYVQDSTLKHIVRNFLHRMNVDIDKAKRVDRTVEIYLDADSLVILKKYLNSKDETITMREQVREIMEELIVPQHYEDRSFVKHAFDMIVSFLPLLNSVLLAPALANIAARMSRAEKSLTEKCKADNFLSTALDIVSGLFVFKRENECEQHYKDLYVDPIYEIAPLEVISEVLSNFIFTSLGVFGRHFNIFFNEFFRDSPLHFIILKAITFFFLIVVFLFWLGGYRIRTLMATVEPSGITHTMSLLQQPIDCRSNDERPKIKSLESRLAPLRINLKSNRNAVSTNIRRRSLSTSRLSMFKVPISDSGEVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I198</accession>
    <name>A0A183I198_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040236">
        <property type="protein sequence ID" value="VDP13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I198"/>
    <dbReference type="WBParaSite" id="OFLC_0001351101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001351101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001351101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001351101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28215" checksum="61C1C02F84528010" modified="2016-09-07" version="1">MNGTKNNLTCTIYHTHPLKDPYCHLNTSSESERTIFQYYSCTCETNNIKARSKTIETPICVMALSISKLGLFYRLHTFHYSRFQFGNEIAPKRFSVSKAKSFSTYTALYNIDLIRHLLTYVVHIHSKTKVPRPYDRCTVFENRKRIERCSSSLGCYSFTRLDTREIMVSKGFTGCVDRIPALVKTLPNLSPLAWCLQMTYQENKYRCRAYKGTTNLTTSGTLCCCEEDCFITSVFLSTSFSDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1F5</accession>
    <name>A0A183I1F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13567</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040269">
        <property type="protein sequence ID" value="VDP14089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1F5"/>
    <dbReference type="STRING" id="387005.A0A183I1F5"/>
    <dbReference type="WBParaSite" id="OFLC_0001356801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001356801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001356801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP14089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001356801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="628" mass="70437" checksum="783415998BE92973" modified="2016-09-07" version="1">MDWNSWEESRRIGFDIAEGAIAFSSDNRHAFIISDNDVIVVEIESGRRKQLLVHPAKIVGLYYAFPGKAVTYTVNGTEYIWSTDTWTVLHCRELNCAPLSIWHSNEITLVITKNENEELIVKKINGNELLQKQEILRTGPHNIGSSQLAITANYFACCEKLFVYLYTFGEIGVKRFKYIGKAEFMDSSLLEFTSITALGDTVAAAISFGRVFIWNNVSRRGISTFSHSVHWHKWAPCLALTESNTLFSAGDEGVLAKFALSELKSIAKPQLLPRLQAPVRRLNLSEDGSIVAVILADNSVHFILNSTLNVLSSMESILCSPKKSLFPLTEDPLHTNYVVHSARPGFMQWIVPSTMISIATADISRKNPLEGENIFSDTTGYTDVCEVALSQTVMVTADNDIGFDIPNNRLQFWRRNEDLGCFALEYYELYVDGVIKFIRACLDYDMFVTADNKGILCTWERIKNDEKKWHKSNEVHWMGVPILHMSRIRNSHFAAIHDISRNSDGVVVLWCVEQGKSPRVVYIHQGNGKLTAVEWASVNNNNLLIISSKSCIYAFNTCTRAPLWIVCEPNLRLAVTSQFAVAYNKNVVSVIDSSSGTLLCQRKLNSTPESIIAVGEGQTFTLVAAYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1W9</accession>
    <name>A0A183I1W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040363">
        <property type="protein sequence ID" value="VDP14517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1W9"/>
    <dbReference type="WBParaSite" id="OFLC_0001373201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001373201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001373201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001373201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13813" checksum="24EC9FF0C55CA219" modified="2016-09-07" version="1">MIPGGGCCEPAVTECNRSYCFFAEVRGSSPFWISGCTDDEFNGCDEHEIPYNSVLLRCQCQTDLCNPIDRIPRCSNELFNNTAIKSSATANDIKSIAWANQIKSLSPIMLLILVPGWHLSNADSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2S4</accession>
    <name>A0A183I2S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14036</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040552">
        <property type="protein sequence ID" value="VDP15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2S4"/>
    <dbReference type="STRING" id="387005.A0A183I2S4"/>
    <dbReference type="WBParaSite" id="OFLC_0001404401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001404401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001404401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057945">
        <property type="entry name" value="TPR_ZSWIM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25572">
        <property type="entry name" value="TPR_ZSWIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001404401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="687" mass="76873" checksum="96FE1297A33B8B1A" modified="2016-09-07" version="1">MEQVEVFVVDEQEGELDPNDAWLMRAAGGEEEVDANELPVGAMAVAQDDDQLSFEDSERFEEDSLCSWMSDAESLNQNWRGWSTTRNPTAQTGIEHTFGDVSGPLLPSSLLRFTGGITSPSQSRRHPVSTSAATTNLGSPASTTSICANIAYKVRSLAEMAARVAARCFSFVMLEACYHAISVEKRRINLRSGMNDRSVILENAFVEHAAIPDKFFLSIVRWCFPESEEDVRLYSCLANGNADEFDRGEYLYQANAVHDVFQIGYHISAVVNATGASSIVTPTSSSAPPCRSKMTYNVSVRVDRCRIVSCSCSCAFKASWCQHVVAVCLYRINRVNEVEYRVTIWDSINELTNEELKKLAQFLINDLPRQYLPVAQRLIDQLRNPNSEINAAVGAPDPTDGGHDNVAIWCLDQRTLHENIRRILIKFCLPSPTVHCDVQYLSSNQPPAASEWLSLFRPHRAKEPEGLWNLLSIVREMFKRRDENATSLLHIITEECLACSQVLIWWYQTALSQSGQWTLCPPSTNKSSSLMSNQKTPQLNCASLCDEIVQLWRLAALNPRLSSFEREQLTSFIQIYHRNAVERIWKYICFLANPEASVSSASRKRRKKSSRISGRRGHQFEFHDERSLIRAVRAAACAAREVALGEEVEEDSAESGQESEAGPSMSRNNNRTNGSTNRNESSASLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3J6</accession>
    <name>A0A183I3J6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum DNA J domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14308</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an important role in regulating the size of autophagosomes during the formation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040753">
        <property type="protein sequence ID" value="VDP16435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3J6"/>
    <dbReference type="STRING" id="387005.A0A183I3J6"/>
    <dbReference type="WBParaSite" id="OFLC_0001431601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001431601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001431601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000029">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052460">
        <property type="entry name" value="ER_disulfide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="161"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP16435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001431601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="56051" checksum="F65D3A97D232ECD8" modified="2016-09-07" version="1">MVKKVLLQKAVSVKGERSTAIGWLPASLSVTFVGILQFANVPLHLSSAMLFVRQKSRITMHFIFISQFLSFLVILCISGEDFYHLLGISREADNKAIRRAFKKLALIKHPDKNPNDDNAQKEFVKIYRAYEVLMDEELRKKYDQYGEEGLSDNFRGNYQYQSWQFYKDNFGIYDEDKEIVTLSRSDFERTVSETDEIWFINFYSTFCSHCHQLAPTWRKFAQEMEDVLRIGAVNCAEDPMLCHSQGVMGYPSLVIYPHRHFFRGERQLKQIVAFAMEYVTGVVLQLTDSDIDLFKMKKNEKYTNGWLLDFCEQRSDDCLSELNRKKLAANLHGLVNVAKVNCDESLELCTLFGRKSGMIYFRPDDERKPSEAWTINSLDFKEIAATVLNYVPDLPYIDKMLEKIVEAEIRDHSFLIRFDSGKMDNNIDLKKLLAKVTTNEIEVYLADCSKAKDICENLKLTKLPKWVLFKKQGSYEIYHGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4U6</accession>
    <name>A0A183I4U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041165">
        <property type="protein sequence ID" value="VDP18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4U6"/>
    <dbReference type="WBParaSite" id="OFLC_0001476901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001476901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001476901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001476901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20160" checksum="0E55EC645FC19876" modified="2016-09-07" version="1">MDETARQVRQKEHHYASQSACPLYFSGNFNLKCCDDRFTILFSSLHREYGTMKEGKKKESYESFGGNAEDQGCVVIVREKRAFRDSILSISSTLPVLSSNWHEELNETRAAYGSLCSYALPQQCNRYLEKPNNNNRKMSAVDERVAEKRKLEEKDTENGVAAKGAKVENGIIAVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I692</accession>
    <name>A0A183I692_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15254</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041832">
        <property type="protein sequence ID" value="VDP21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I692"/>
    <dbReference type="STRING" id="387005.A0A183I692"/>
    <dbReference type="WBParaSite" id="OFLC_0001526501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001526501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001526501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061118">
        <property type="term" value="P:regulation of positive chemotaxis to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001526501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22608" checksum="4367D71DBD6CF81F" modified="2016-09-07" version="1">DAFIQVVVLGSGGVGKSALTVQFVSNTFIEKYDPTIEDFYRKEIEVDGHPCVLEILDTAGTEQFASMRDLYIKNGQGFVVVYSITSQQTFHDIKTMREQIIRVKGTDQVPILLVGNKCDLIHQRQASTFKGLKYYLKDNKFEMVRTEDGIGLAEYWSCPFTECSAKSAHNVNTVFAEIVREMNYVQNARIKQNQGCCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6N0</accession>
    <name>A0A183I6N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042056">
        <property type="protein sequence ID" value="VDP21647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6N0"/>
    <dbReference type="WBParaSite" id="OFLC_0001540301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001540301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001540301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001540301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9443" checksum="BDCE213202BFE7A5" modified="2016-09-07" version="1">MSVFRTLEHVLLELTRASGYTRNPSDCSLFRRLQVLHTSGFYKALSTTSAGREVNTRDSHRLPWPGLDYGLCFHNHRVSYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I809</accession>
    <name>A0A183I809_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15871</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043108">
        <property type="protein sequence ID" value="VDP24447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I809"/>
    <dbReference type="STRING" id="387005.A0A183I809"/>
    <dbReference type="WBParaSite" id="OFLC_0001588401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001588401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001588401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP24447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001588401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16434" checksum="E46A5CD26B95B9B2" modified="2016-09-07" version="1">MCNAPPPLPPPPPPPLQTVSCGECHSGYRITAEGVENSVFLRSPSSPARRRSRSRRRSRSRSPRRISRYSPIRRSRYNDGRDNPEPCSCLGVFGMSLNTTERDLKRIFGEYGEIESVQLVYDRYSGRSRGFGFVYFETTKEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8A0</accession>
    <name>A0A183I8A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15962</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043379">
        <property type="protein sequence ID" value="VDP25397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8A0"/>
    <dbReference type="STRING" id="387005.A0A183I8A0"/>
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        <property type="protein sequence ID" value="OFLC_0001597501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001597501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP25397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001597501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17440" checksum="34A410B99DFA13E9" modified="2016-09-07" version="1">MIGKRDKKQNSTHFENNEVEDEKTEMLSGSKSNMKKAGECIQKIKTSAKLDSRCKSWRLIVRNLPFKTTQEDLQTIFGDIGPFTEIVLPKCKDKRFQNSCAGFAFIQFWKRQDAVKAIEKLNMSEVFGRKIAIDWALSKDTYETAVHEGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8C8</accession>
    <name>A0A183I8C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043493">
        <property type="protein sequence ID" value="VDP25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8C8"/>
    <dbReference type="STRING" id="387005.A0A183I8C8"/>
    <dbReference type="WBParaSite" id="OFLC_0001600301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001600301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001600301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001600301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12459" checksum="E04716E0372DCFBB" modified="2016-09-07" version="1">MKSKVCCWMQRRNLKSIFVVACNEVSTLNRTENVGEDLSTISHLLENLVGELNHQKIIDNLMEQRSKAERLLEDRKETITDVYDKIVELEKQISENTLEEPLEITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UXB1</accession>
    <name>A0A3P7UXB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000048">
        <property type="protein sequence ID" value="VDO24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GY77"/>
    <dbReference type="OrthoDB" id="10261598at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09120">
        <property type="entry name" value="PLDc_DNaseII_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09121">
        <property type="entry name" value="PLDc_DNaseII_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858:SF24">
        <property type="entry name" value="CELL DEATH-RELATED NUCLEASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="365" mass="41947" checksum="C55A3F25C644C0E8" modified="2026-01-28" version="1">MFLKLSLLFSLILHVCIALSFQCRDQENRDVDWFIFYKIGRIKKSTVKSIRDGSAFLYMDVNDQKWSLSAVDIDNPNQAIGYTLQQYYDVTNNPEVFSIMYNDEFPYPNNDTLSGSSGHTKGVVVFGKSNGFWLIHSVPKFPRNDTYEYPVTGLHYGQMGLCLSMSYSQLHKIAIQLYYNHLFIYSQRLPAQMAENVPILVKVMSKKYQHTAPYVSRVVIYSTAGREFVHFAKTGAFDKGNLYFDLVAPAIKSSLKTETWQHETPRNKNLHSWCRNYSPFKVLDVKKVILPFNISFPNALDHSKFAVATFDAHKIPVPWICIGDINRQERQLLRAGGTMCFANSEVHAIYTSMVSNYWPCIRTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VPA2</accession>
    <name>A0A3P7VPA2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007416">
        <property type="protein sequence ID" value="VDO49950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VPA2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="3">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO49950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="291" mass="33888" checksum="F2C60B762D60DF4D" modified="2019-02-13" version="1">MEEKVEREKRTRLDLEKAKRKVEGDLKVAQENIDEITKQKHDIEQILKRKETDLMSAVSKLDGEQSMVSKLQKQIKDLEGRIAELEEDLEQERQSRSKLDRAKGDLQRELDEIMQRLDEQGGATAAQIEINKKREAEMAKLKRDLEENNMNHELQISALRKKHNDAVAELSDQLEQMQKMKAKLDKDKAQILRDLEEANANADAESRQKQEFEKQSKLMEMQFSELQSKADEQTRLINDFTALKNRLSNENGDLSRQLEDLENQINGLHRLKGQLLSQLEEAKRTAEEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VUQ5</accession>
    <name>A0A3P7VUQ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002787">
        <property type="protein sequence ID" value="VDO38214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VUQ5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125237" checksum="9F5E01E7ADB95340" modified="2019-02-13" version="1" fragment="single">MNSGEYPSEVTVEESLVPAGSAATIHCETITQQYSLDWRKDLQPIMQNERIEKKDTADGFEHSLTIHSVRKNDEGEYGVVIKDSYTAVTKISVIESQEQIATEDFDISLHPTPSLTNEAFAQSCDRVNLQNNFEAYQLCNMEEYFDLQFSMQSFEIPVIVDERRSASVSYLSRELSIQEMEKEIDMHREPSYATSKDLTFMEVTIIECNFVTTNTRFEFTSTSVAHAVAEPIVLTLVAQQSAQIHLSSRYTELRASFINQSIVEQLTATISARPKIVEKLETKLGDCWVKLDVILLSPMQTIATDIVNKICTMIALEMHLPALVFEDCNNTITFNRTSEGEFCDAAIPIKLVTFPEKIRRQFTVNNTWLELIAVYKVPQIFDSTIKIAVARKEMLYLQCKASKANIVDEIFAVWKPIQQQDAAVTFPVTLSATISENYIDSISSLEIMLQSHLDRNMLTSKEIPLIQTEMISVQLTAASIEIFPVIYNFSKSAQDENVEVEIFVKPLIQCETSTRNFIDSVAKVDLEFWSKTERNLFIIADFRAVETNQLSARFSDSVEEYFTISTAFNTQSELDATVATLLIKAPKIVEKTNRLFSDTTVNVISEYQSYVCREFCADTIFLTPRINACMANFRVSTCENLYATASFEIQSQENNVSVTLLMRAPTIVERSSIMFSDDLVQKTVEFQSQIKHSLEIEKEVFIARKDILVENIKSAEFEEKDIIVMIDKRPEKEISEILLLRPVPALTQKFSRSFSDTVVYLNTELYMENFDFHANRNIRIGRTQTLQMHLKASNEENISVLARFYIQDEIEKIMATLPMRAHTIIARDDRKFSDSVVKSATQLWSQICREAFMDVDIYIARKDDIQRQFKASAVEDTYTSIALEEYPEAEELEVTLSELIQADTFKLSRFFSYKTVDFMATLWSQAESNFYASVDVPIKRKNNNQLYLKASSEEYINTSTSFEAQTKTDNTMVVLRTQVPSVVERSSRKFSDTSAELAIEIWSQLCHETFADRSIYLKQKDSIKLDLNTTTFEVQIFLTNFELQSQVENITAILPTRSPTIVEGTNMVFSSNVIKTVFEMFSTVNRDLHASVEAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W0K6</accession>
    <name>A0A3P7W0K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002399">
        <property type="protein sequence ID" value="VDO36903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H7T2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="202" mass="23870" checksum="CFFA9B2DFA458781" modified="2026-01-28" version="1">MAFFIHNLLQPSEVTKTSSSVRDTLNETGFCDETLGSYKSLQVTCRTNLMGSFSSPEWYQAVNYANMATQHIGHQFSRTNSEHYPVIIGWDPRLPWLQPYVQKSQHKRKGGQIRFTNEQTDALEQKFDSHKYLSSQERKKLARSLQLSERQVKTWFQNRRAKWRRIRKDEEDEIHPDAIIHPISQLIHYGHHQYHSSFKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XIG5</accession>
    <name>A0A3P7XIG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000603">
        <property type="protein sequence ID" value="VDO29122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1G4"/>
    <dbReference type="OrthoDB" id="5804615at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF28">
        <property type="entry name" value="SGNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="431" mass="50181" checksum="25AA49447118EA62" modified="2026-01-28" version="1">MRTEIALILVIEGILCNDTRQRLTELLRTDQKFYDQWMHLIELQHRQFHEQNMGSALEEVADLVLNCAPKLDLKLDHIDYVCPADIQLYAELGQLTRYCNDSIIELIKGRMDSCQHASYTSSLPSIVKFLMKFIRNLTVIESSNETKLENQTQYLVKKFMEHRSWRSKWKLIVIMPNMEDGELQEPEQSAVEVMKSIKLLYEVIPQRTILIVIRSSTLQLWQDASYAHRACQTLLEPWKLYQKLNPVSIWDQVEKICELHFQSSLFTVQILPLMKDASLPFLSGSNQIDLSLLGHDCVHFSPRGLSLLHIAIWNAILTRLPDRSQKFNFTLERPLCADPQCPFVRTKKNSAFCVWNHQKINKDDRRSEQLIAMSVLIIAMILFVIILGTVCCFRRHNDKINEIAENFPKKPPVGVNWTTWKYIDEDNSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AL03</accession>
    <name>A0A3P8AL03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039835">
        <property type="protein sequence ID" value="VDP11231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HY35"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="159" mass="17688" checksum="7987D280F7AF2A0E" modified="2026-01-28" version="1">MSKMGAINSDTDPDTVTILHRRGPAQRTLRTAAELNAAQRRGMAIETSKKMMAGGNRQHHAAKNTARLDEETEELHHERVSLTLGKVMQQARQTKEWTQKDLATHINEKPQVVAEYENGKAVPNQQILAKMERALGVKLRGKDMGQSLANKNASAIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B0K3</accession>
    <name>A0A3P8B0K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014396">
        <property type="protein sequence ID" value="VDO70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B0K3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="185" mass="20185" checksum="0F4992F79179EC28" modified="2019-02-13" version="1">MIREDDFGIAIDNSLLVQISPEGCTSKHAQQSAIAADALLGEIGKCCRDFFTQSHKSDKKLPPAAVGKAFRLKDISAYWLISPLLHACPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNNKERIQQSAWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDVSSGIYSIPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BII7</accession>
    <name>A0A3P8BII7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015229">
        <property type="protein sequence ID" value="VDO72685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BII7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF283">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO72685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="23402" checksum="FD7454C8919E5F7A" modified="2019-02-13" version="1">MSSINSIFYRSEYRYKRAITGPAAIRKLRQAPFCQCDINNRCPPGPPGPPGLNGQDGTPGLPGPIGQPGLPGNMPAINYNYEGRCRSCPNGPPGPPGPLGQRGRPGGNGQPGLPGNRGQNGHNGPPGPPGPQGEAAIPGRPGEPGLPGVSGPPGGKGIPGSPGTPGLPGPLGTPGQPGSAGKQGLPGPQGPQGPPGQVGPDGQRGAPGPSGPPGRHGEDAAYCPCPNRRVAVSLQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EQG5</accession>
    <name>A0A3P8EQG5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040294">
        <property type="protein sequence ID" value="VDP14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8EQG5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="282" mass="32008" checksum="18CD4D26F4D4A04C" modified="2019-02-13" version="1">MFQFFHFFICRSNSLSEEILHETTEFTEACSSAIKNHKLFPIVELMSKKCEAATQNLSEASFTMEDVFQQLEEMASNSDESLGNSELDIFLINSIIMLRLHLLELQKVAELCDDFKTKYLQALRKKMTQESMIGYNGDSDDDLCSSPLALSDQLKNRTGQQTIAMMSTSKGMLSIPLWNTIASYSSSAHASLSQPRISEYCSSSGIQIPEHPYPSEKEKAMLSRETGLQMVQINNWFINARRRILVQSKENPDVDLIQESSSSIDCAFIPKRIRSYYCIAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FFL8</accession>
    <name>A0A3P8FFL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042323">
        <property type="protein sequence ID" value="VDP22419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FFL8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP22419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="294" mass="32469" checksum="C158A0D79BACC67E" modified="2019-02-13" version="1">MISADPTLEHTIPFRQWRPHSLSVSDISVTHHSNARILSCSRDYTAALHSVTADICLLKISCDMALSSCAIDPAECRLFLGTINGSLVQLDLYALNKTEVSIVIGAENTGNLLSFNGHSTELAWLDVNHDGSLLASGDVSGVYMIWDISSRQCLKTSSLKGPICKLKFNTRWKAAEESSKKNQTFPIPNLKRQKERKLPAFVLLQDGISDEKNEFCVANLDRIISDYAKVEIQITAPTDDEPQTEHTTEDVKSLENGESSDSKTIKLLKAKIAALEEANQQIYDFAASLIIDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXY2</accession>
    <name>A0A183GXY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS92</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000021">
        <property type="protein sequence ID" value="VDO24500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXY2"/>
    <dbReference type="STRING" id="387005.A0A183GXY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000009101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000009101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000009101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="374"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO24500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000009101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="65632" checksum="C954357F1769DBFA" modified="2016-09-07" version="1">MVWNLARLGDEQEDEGLKVLQKFCRRKYRRSLTNALRSSKIHKPESITAEVQNTESLGLNANNVIADTIDYDGNSIYSEGISQPNVYDVIEEILNSRSKSSERNPIKLMWYNLEFRLGRWIKCVLLLLVLIAYALFGGFLVHQFEAPAERELNAQLDQESVQRYKTYVKKISELFTSPLCQSTIKHSDDQNRTEMRFIEYSHLIAPFLKQITCNRRLERLLVAYDEQLGISAYKQNPWKWADYWNAVFYCGTIFTTIGYGNIWCRTTEGRVFTILYALLGVPYMLVVLNEFGKLILVYVRNIWLFIRKGLKCFTTQFILRRRTREYEVSNEAQVNMKKTGEIVENNTCDNNEDNSMNEEDDAYETFPIYGAVLIIVVYIALCSFIFRIWEHWDYFTAFYFFFISLTTVGLGDEMPGHPHFACVFFIFFIVGLALVSMCVSSVQMEFEMRFMKAINLIDEYSRERQRRDQKNLLKTIEGPVRFMNSVPVLNPIAFIPTVSNDLTKQRCLFNDCLGFHVCFRCRNAPSEESQQIFQRVPSVLETVLCRTSMRLSKMKRQETISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYH4</accession>
    <name>A0A183GYH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial glutamate carrier 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS284</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000082">
        <property type="protein sequence ID" value="VDO25254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYH4"/>
    <dbReference type="STRING" id="387005.A0A183GYH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000028301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000028301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000028301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO25254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000028301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26149" checksum="7EC56436F6F1F251" modified="2016-09-07" version="1">MYSGMGVNVLLITPEKAIKLVANDCFRFYLAVPNQEHLSLTRGMIAGGGAGFCQIIVTTPMELLKIQMQDAGRTGRLEQKKLSAISLTMDLLRKKGIFGLYKGITPTMARDVSFSVLYFPLFAYLNSLGPRSSDGSGTTVFYASFCAGLTSGAFSSFAVTPLDVIKTRMQLINRGEGETEYRNIFDAFTKILRHEGPRALFKGAACRMLVMAPLFGIAQMVYYIGIAEFFLGIPKVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H072</accession>
    <name>A0A183H072_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitogen-activated protein kinase kinase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS882</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000358">
        <property type="protein sequence ID" value="VDO27437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H072"/>
    <dbReference type="STRING" id="387005.A0A183H072"/>
    <dbReference type="WBParaSite" id="OFLC_0000088101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000088101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000088101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF304">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="207"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000088101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122175" checksum="8400F257D7E8F71C" modified="2016-09-07" version="1">MNFSTTKKSTKIPSGLRRLEDQSHSILLQDISSSQYLHQVPVNNENSDVEISTLIVHSTVDGLRRTRRCGDRYTFSIGYETMTVNSELARMMSDQNFASCKMNVNQSAPPAPFPKRLFADSVIVDEISVNNRAISPPGIMPAGINSGFQNLAPSNRSAIDILYRGLFSCFKPMWSYFGRSTESLLSGITKSTLAYPVDNWEIPFETITHLEWLGSGSQGAVFSGQLNGRLVAVKKVKDKSETEIKHLQHLNHENLIKFIGVCTQSPCFCIVMEYCGQGQLYEVIRSGHHIVKDTFGEWARQIGDGMNYLHQKRIIHRDLKSPNILVDNSDILKICDFGTSHQWDKQKSTVMSFCGTAAWMAPEIIKKEPCSEKVDIWSFGVVLWELLTQEIPYKDIDSMAIIWGVGSNNLSLPIPDTAPEGLKLLLRQCWSIKPQNRPSFSQILKHVAVFKSEIANISDEEWVEKKAVWKVYVIEYMKGVRQEKPMAQKNDALNERELLRMRREELKHAQDIREMYEDKLRRAAKIYSKLERCLHDLAVREQELVERERYVSEREKYGYNMCVKTNIFPPKSTLKNVKNVVMRMRPESNNTVSVTKQSVDVCSSNRALSYEGQEEMSSSEDEYRSDLVYRNSSARCSASSITTSGAFPSSQSLNFSRQNSGRSSLGYNRKSNKTSPRIPTSNSDTIEKLGTYGYKMMQIIIAEHNFSRDSSMRLSNYFCSYQTDLVRRSPTRNSGISEASCDSGFHNFNDAEFACGTSASGLVYECSLCGQPVNSMNFYRNAEGRWSDGRLTSQRRKNKRNVASSHRNSLQRMASVSTKEKRSPYTRSRQSLAEVALINNGATRKTPSHEIIDNTIVNSQNKIVSSPTTTKSTKAEMLVDEESSVTIPPSTSCQGIVKHEHTIMSNKQAVACGSERSSERDDRPTKEASDASAEESSEERDENNGNIFGSSLDSASTCCVVFQRFRNPQSTNDSERSSCQLITSSSTMESSLERSLEMAAIHSDGLSDKERQVRAVKNTIRTHRRTASVSSNLSTKEFLIQIKSFLFFLNESNILEAARQRTPLSIPSAVCETTSESDAEQTAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0E2</accession>
    <name>A0A183H0E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">START domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS952</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000394">
        <property type="protein sequence ID" value="VDO27701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0E2"/>
    <dbReference type="STRING" id="387005.A0A183H0E2"/>
    <dbReference type="WBParaSite" id="OFLC_0000095101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000095101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000095101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF3">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="56"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000095101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27963" checksum="4A5E22DCD489AD2F" modified="2016-09-07" version="1">MTTINVGGLSEALPARLNKAIEKTSDLQYSNAFKNAENAMKLLLEICASPSFETMEGWNKSYEKNGEKVYSKQFDIGKIFTLKIIFNETVQNLFYEHWDKITTTPLWNPNFTYMERIEKLTSHCDILKFATTDIMFVKGREFLACRLYRKIGRIIYIAARSFEINEIPEMKGKVRADMLLGAGRFSPHSPDPQKTLIDYAFCVNPKINLPQRLIDTFIAYTIHRDSVFARKNVQKLREGNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0P4</accession>
    <name>A0A183H0P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1054</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000450">
        <property type="protein sequence ID" value="VDO28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0P4"/>
    <dbReference type="WBParaSite" id="OFLC_0000105301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000105301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000105301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000105301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27145" checksum="8C9D432E1916FCA2" modified="2016-09-07" version="1">MSEKLATMNLQVTQPIQFRSTFRCFTIAHVRRSKCSGLTIPTTVTGAAVLDIYSDLQDSDFLFDSETMHYTFDETSSQYKIKLIMWLALLFVMVGIVITVLILTISKMQAISSTSLYASHHLEGHFLITEGPLLKFDGRLLQKNTNEFMTHANKIQRQLNLIYRQSNYGLVYTDTEVTKFRFVPAVPALDVTFILKTRSDLNVDVSNFLSTLRNYVRARGFDGNTIDDKSISLEIKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1K9</accession>
    <name>A0A183H1K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SRCR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1369</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000629">
        <property type="protein sequence ID" value="VDO29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1K9"/>
    <dbReference type="STRING" id="387005.A0A183H1K9"/>
    <dbReference type="WBParaSite" id="OFLC_0000136801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000136801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000136801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="852"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000136801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="964" mass="108639" checksum="14A39BE0B418D6CA" modified="2016-09-07" version="1">MGFNDGGFWKWYRRNNDTYPFVMPFPKCLSNVSSLWNCKGFNNPNLIPLSENLCQGEDDIGIRCWGTPVFLGWQKHWKGLQIFSSSSQYVNSDPDMVALHQESTSRLEFIDILYAGYDGSTKNTTAAIWIEGIPPIMNGLRIERSARDGIHLEKPTGPVVIANSTIRNNRGHGIAVMNTTDGRVFINMTTITGNYGDGIHYREGYDTSWYHTISDNGSEKDLLIFQDNRKPRLDMCIEHKIPENFFFPHLIQAKLTNGTVIDSNSASPCWMIVSLPARLLYTYSIQFMAISNENDENLDSETRLIICDANVNFDGCDGERYRIPILNRILPQTISFRSTGQPIYLSLEHIPSGLSGQVAGDINLVFRIHASVTDKAFYGLNITHTLIANNTGNGIWAQDIRERTTLTNVTILENQGEAGFLVRDGAADIWINASQINDNWGDGINVSYAGGSVTINGTIISRNKWRGCAFHQNTSSPYLPLYQEIIIKGRPSNNIFYLRTQIVDNAWGGILIGNFCIPLSKNIQPKILISWTELIGNRYHASVEIFACQKIGMASTIVDFTGNRIEGGLGVGFRMEPAVNTITIISSNQFIANNNTALIIRNARYPQLYNLPAQVAISKNSFKFNIGQSIISIGMVEDSQVQNLTFNQQNEVRENRVINPFPYLNPRSTPYAALVVSSSNVIINRNCFKNPQATYEIGSELAEHAKWIDARENNWGHPRPELFMHRIFDQFNRYTLAAIEVNPFAAVCNQRRPHITTVQQYYRLFRKDSEPYILGGTIWENQDLGKGLYTVMDDLNIVPGARLTLSPDAVLQFNNGLGMLVQGELVRAELHSSDEMVKFTSTPFILPHPPNIRLVDENNNTEVLAGRLEVYANNQWGTVCNRSWTKELALLACNQLGLIMDPEYFENWQIFPSSGELPIVMDNIRCEENEYDITLCRHDDIYHNIAASCAPTNVVGLSFFFFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1N1</accession>
    <name>A0A183H1N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000644">
        <property type="protein sequence ID" value="VDO29362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000139001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000139001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000139001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000139001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11899" checksum="0E9237706083A2C6" modified="2016-09-07" version="1">MSVASWRSRTSSPIQSTLRLEKQHQYRFFPGCKCASSGSCAVSGPYNPPFGNFSSVFSERKKNGWVIWSANSCMPPSYHWLLITIIKATLVSNSGPVLTCCEIFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H231</accession>
    <name>A0A183H231_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS1541</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000742">
        <property type="protein sequence ID" value="VDO29915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H231"/>
    <dbReference type="STRING" id="387005.A0A183H231"/>
    <dbReference type="WBParaSite" id="OFLC_0000154001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000154001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000154001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="261"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO29915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000154001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48563" checksum="9F5148A5E93CA051" modified="2016-09-07" version="1">MKQIRKVVCAISGGVDSAVSAYLLKKRGFDVIGVHMVWFILYTYLLPRADGEFATINWDRVEEDSSNCPQSADQKDAEKVCNHLQIPFHVTNFVDKYWNEIFTFFDTYFKEDYLMDNYRKGRTVVSDVLCNKAIKFDRFHKYAFDELQADAVATGHFARTSFGDFLEKRLETGCDFSLLHYFIRSDYLVIRLLAAVDPIKDQTFFLSTLTQSQLRRSMFPIGSLTKQQVRQIAVDIGMAEIAEKPESMGICFIGKRKRFDTFLDQYIEPVIGPAKDIDTGKVVFEHRGIHHYTIGKRITMVPDYCQNAIGLFAAGLDNKTQTLWVCQGSHHPALFAREFVVEEPLWISECPIDDAGVVKTEFRCQRTHPALLCELTRLEKGLLKVKPYNPIRAAAPGQICVFYNDSECLGGGEIQYVVTTLADVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2K9</accession>
    <name>A0A183H2K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000864">
        <property type="protein sequence ID" value="VDO30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2K9"/>
    <dbReference type="WBParaSite" id="OFLC_0000171801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000171801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000171801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000171801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9877" checksum="8CA35963BF2767A1" modified="2016-09-07" version="1">MGGRAGEEDDFNDTDTRIDQSSIIGVIGMKELGRKQLLQSDNIWERDGEYNNHPCGPRLEMRRGGKEVESGTDTMIILTRDGIPVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3R3</accession>
    <name>A0A183H3R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001159">
        <property type="protein sequence ID" value="VDO31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3R3"/>
    <dbReference type="WBParaSite" id="OFLC_0000212201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000212201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000212201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000212201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16307" checksum="9EA0D7D5E27E5ED5" modified="2016-09-07" version="1">MTSLSIACLQAKQLSTIEQEEFTCQIIRRKFLNAELLQLHFFDKNMGFQDNCCSALIRKNGIATFEGIWYFFLVRGTQSNSSTFLDAIWCLKMDGAHEKEVIMFGRRSSDDTFVEMPDVAPLFAVAITSIIRTSSLIISKMTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3S0</accession>
    <name>A0A183H3S0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fmp27_GFWDK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001164">
        <property type="protein sequence ID" value="VDO31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3S0"/>
    <dbReference type="WBParaSite" id="OFLC_0000212901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000212901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000212901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000212901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23203" checksum="40883581BEEE987D" modified="2016-09-07" version="1">MHNFQMFCVQKKKNPHLSMCDAKRDRSGPGPAFCSRILYLLLTDIEIVIKKQEVLHMKQLLQLDIHNFMEIRHWNSLGVLGDAVYLVNVMKSEKMQDVPISAAMGQTEFEIRQENFEIVGRDDLSPVDGRQLSMSGETIIFVWGCSSFVEKETKFEIRRETWFLVDIARVFHQVLMDVEREYVNAERKVGSRIPVHLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4W5</accession>
    <name>A0A183H4W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps39_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2525</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001470">
        <property type="protein sequence ID" value="VDO33283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4W5"/>
    <dbReference type="STRING" id="387005.A0A183H4W5"/>
    <dbReference type="WBParaSite" id="OFLC_0000252401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000252401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000252401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="1">
        <location>
            <begin position="53"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated zinc finger" evidence="2">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000252401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41593" checksum="DC15E55AABCDCED5" modified="2016-09-07" version="1">MEQAHIEGSPLRGCNMTVEYLQKLGNKYLDLIIEFAAWVLQENLNAGLSIFTYDSEEVRSLDRERVLIFLTHECIAAVVPYLEHIIYKWNEDMPKFHESLGQHYISKVKQLQRDYINILGEDEHIAPAGKEEGELGEYRCKLQRFLQTSTAYSPEKLLVQLRHNSLYEERALLLGRLKKHQQALAIYTQILKNYKAAEKYCMNCYDPKDPEHSKVFLILLQMYTNPPDTSIVGLMQSDHCQTVPNPNEAVRILKEHSDLFDPVEAVTSLPLDYTIKCVWPGLVTILQRAHDKKHSTMIHKSVCDAALKRALRRKTISHSTKFVIDYEIECAACGKKIANSAFARYPNGRLEHFYCYQRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Q4</accession>
    <name>A0A183H5Q4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Large tegument protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001716">
        <property type="protein sequence ID" value="VDO34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Q4"/>
    <dbReference type="WBParaSite" id="OFLC_0000281301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000281301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000281301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000281301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="31337" checksum="20D57BC0E447DA79" modified="2016-09-07" version="1">LCCSRSAKGRPRTRKGRASVAGRVATGAESSRTANNSEQQPSTSSSARTRAQSSATGLCHSITRCESTANRVSPAFVQQGEPSSCRPAPQFGVVVQDTTDNATSNTIAVSNNATLTAPTNNSAATTTTATELSRAVHGDINAAESPSSQFRNLQRSQAVHTASSFLGALVPRVQHLLGSAHSHPNPESLPDGISNIITGVRNTTQGQLNDSLSSGNLWRGIAHNFPSRFGFPGFTVAGRNLKALVIRGSDNLFQIMCSRGLRHIQPVGADLGTDSQRHRNMEIVNHGQGFIRAEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6H1</accession>
    <name>A0A183H6H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3082</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001952">
        <property type="protein sequence ID" value="VDO35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6H1"/>
    <dbReference type="WBParaSite" id="OFLC_0000308101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000308101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000308101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000308101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7799" checksum="CB6A52BD053E6D36" modified="2016-09-07" version="1">MEEKLNVIGDALEAIYNTTVSNERRAAATEVSKDSSLLLRLVLLLISALFADADLLKSHIRYNVGIILAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H703</accession>
    <name>A0A183H703_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein Abitram</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002130">
        <property type="protein sequence ID" value="VDO35869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H703"/>
    <dbReference type="STRING" id="387005.A0A183H703"/>
    <dbReference type="WBParaSite" id="OFLC_0000326401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000326401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000326401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000326401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19095" checksum="69D831945141C063" modified="2016-09-07" version="1">MASEGHINELLNYRSVIDRNYKRYILKNDRNGLCYLRHPNGVIVVTLYKNHELMRKRIKTIDWQMKKNKGIDRSKQKVSGKGKKGGLVLLPDTKFCIVHCEDGTEYVLRAGIRALLIEVNERLLEDPNLMRTAPENQGYIAIIIPYSNERRQPPQSFLEGQLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7G5</accession>
    <name>A0A183H7G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">JAB_MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3427</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002282">
        <property type="protein sequence ID" value="VDO36453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7G5"/>
    <dbReference type="STRING" id="387005.A0A183H7G5"/>
    <dbReference type="WBParaSite" id="OFLC_0000342601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000342601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000342601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO36453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000342601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10938" checksum="D101DFB423BBD6C9" modified="2016-09-07" version="1">MAPYKEDEGKVNTVTKIGDIVKPHCASNVHVNLHVSKVVVHPLVLLSVVDHFNRVSKTQNVKRVVGVLLGSMKSDRTLDIANSFAGKLFFFFFVLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Y8</accession>
    <name>A0A183H7Y8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="12">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3600</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29315"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="EC" id="3.1.3.94"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="12"/>
    <dbReference type="EMBL" id="UZAJ01002465">
        <property type="protein sequence ID" value="VDO37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Y8"/>
    <dbReference type="STRING" id="387005.A0A183H7Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0000359901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000359901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000359901"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000013">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000002">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020552">
        <property type="entry name" value="Inositol_monoPase_Li-sen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00378">
        <property type="entry name" value="LIIMPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000359901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31391" checksum="5E8150663349D763" modified="2016-09-07" version="1">MNCQLFHPEEDRFFNFALNLVNEAGALVRAAFEQPCSEVQTKMSNTDLVTETDQAVEKMLIENLSKEFPDHKFIGEESVASGAKINYTDAPTWIIDPIDGTTNFVHRIPMIAICVGLSIKKQLRAGIVYNPITKELYTAQAGRGAFRNGFPIHVSATKELNRCLIAQSHGIHNLVKFGEKWLKITLDNHGRQCLAGIRGHRSFGSAAINMVYVAQGVVDAYVEYGIHAWDVAAAGIIVKEAGGVLLDPTGAEFDIMNRRVLCTSTPELAKAIESTLSHVEYEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8L8</accession>
    <name>A0A183H8L8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3830</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01002694">
        <property type="protein sequence ID" value="VDO37896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8L8"/>
    <dbReference type="STRING" id="387005.A0A183H8L8"/>
    <dbReference type="WBParaSite" id="OFLC_0000382901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000382901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000382901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO37896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000382901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36922" checksum="7ACF1C9D3221B1CC" modified="2016-09-07" version="1">MYALKKLEKKRVKKRHAETLSLNEKQILQKINSPFVVNLAYAYETKDALCLVLTLMNGGDLKFHLYNLIPGGFEEKRVQFYAAEITLGLQHLHKEHIIYRDLKPENILLDDYGHVRISDLGLAVELRDNEPIKGRVGTVGYMGESILKLFYCWLKYHCKAPEVIKNERYSYGVDWWGLGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKYSDKFSESTRTLCRGLLHKEPGFRLGCRRVDKPEEGAEELKSHPFFVQGDVNTGREPIPWKKMEAGKLAPPFCPDPRAVYAKDVLDIEQFSTIKGVRLDATDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8U0</accession>
    <name>A0A183H8U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprotein allergen nematode domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3902</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002770">
        <property type="protein sequence ID" value="VDO38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8U0"/>
    <dbReference type="STRING" id="387005.A0A183H8U0"/>
    <dbReference type="WBParaSite" id="OFLC_0000390101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000390101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000390101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.30">
        <property type="entry name" value="Nematode polyprotein allergen ABA-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032487">
        <property type="entry name" value="ABA-1_nematode"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038289">
        <property type="entry name" value="DVA-1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16469">
        <property type="entry name" value="NPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="1">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="1">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000390101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="26050" checksum="E0E5643FB54FB81A" modified="2016-09-07" version="1">MSSRFLKIFKCLSEEDVVLVIPVDKFEEERRIEKWERIDSLNMWKWLTLEQVDMLNKLYKTTDDMALVLEKAYAELLMTDGGLREMAVRSFRETCKELLRVILGERNYDLIADMYNFGRTGEEISEKLSQFYMRLSKTNKKYADMIAPTCMLVYNIYGSRAIRYPRKINEDNLFVKQIHWFTREQETEIERMLAEGARNENLLAKILDYYENLDSLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8W8</accession>
    <name>A0A183H8W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3930</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002800">
        <property type="protein sequence ID" value="VDO38265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8W8"/>
    <dbReference type="STRING" id="387005.A0A183H8W8"/>
    <dbReference type="WBParaSite" id="OFLC_0000392901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000392901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000392901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF137">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552432" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000392901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21854" checksum="C7A28CC948CC76BC" modified="2016-09-07" version="1">MYFTILILFFATLNTRISGDANVSTLLLTNTNVHNPGLLMRLMPSGLAYLREIGMKVVNDEILRIQLPTITETIETGQVSIYDAYVSKYWSPPDYSLELSPPDMFTWSMAKMHIRAAGEFEALFTGPLLITAVPIRGQFETLFGHVSLTMAVRLVRTRAGAPMVQSTYCRADVGYVDLNVRNTGVITDFFINTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8X7</accession>
    <name>A0A183H8X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein HEXIM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3941</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002812">
        <property type="protein sequence ID" value="VDO38308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8X7"/>
    <dbReference type="STRING" id="387005.A0A183H8X7"/>
    <dbReference type="WBParaSite" id="OFLC_0000393801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000393801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000393801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO38308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000393801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18903" checksum="9302F7682798C68D" modified="2016-09-07" version="1">MAPYNTTQFLLEDHEKRTMPPDVSESVPGMAVYHRQSTGGFSPIHERCGTIGQSGSEMGGNTTDSASYSGAEDDEMERQFDADYDYVNMERISNMSKDQVVREYMQLEKINDRLADRVSLLQLENEKLKQLLKDHNVSYEDVISKIRRHSGTSVSETGDAVRKNLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA33</accession>
    <name>A0A183HA33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003255">
        <property type="protein sequence ID" value="VDO39706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA33"/>
    <dbReference type="WBParaSite" id="OFLC_0000434401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000434401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000434401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000434401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9690" checksum="0608FDDF5B4CD81D" modified="2016-09-07" version="1">MAGWTNGGITFDRMMLNSLHVGCQFSQSNQRHIIVTNEKMSIFLENIILIRRKGREKSEVNLCEINVHETNGDTKRWGKEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA76</accession>
    <name>A0A183HA76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4388</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003306">
        <property type="protein sequence ID" value="VDO39835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA76"/>
    <dbReference type="WBParaSite" id="OFLC_0000438701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000438701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000438701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000438701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15542" checksum="F04DCA11D5EA9A4A" modified="2016-09-07" version="1">MFEEDEDEERRKHEDTKGTSRKRGYQIDVLLLPKKTSGYHLMMGMNGAFILSQLWLVIAVRSTDDYDEKGLAITTEVDFPAVNQETSSTSFPLNNLTQRPHQQHDENHSLEERNHRFQAHQERKGLLYFNGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAD3</accession>
    <name>A0A183HAD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4445</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003380">
        <property type="protein sequence ID" value="VDO40033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAD3"/>
    <dbReference type="STRING" id="387005.A0A183HAD3"/>
    <dbReference type="WBParaSite" id="OFLC_0000444401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000444401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000444401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF57">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE TRANSCRIPTION FACTOR MYB_SANT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="39"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000444401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24704" checksum="106F5B00907A5E77" modified="2016-09-07" version="1">MESGQSSSPVYEEEIEADLSVRVLNHSIEEPEPCSFNLRLIEAVRSSRCLYDAKDRLYRSADHKIKVWNRLVHILQFDGDARTLYNRWKQLRDKYGKEKKKLKYGTEHTGWQYFKHLTFLDPHMIDRQQQQFARAKEGKGVMLSPGGTPHHIVINDPTFSLSLIQEVQQHPCLYDIRDPKYRHSECRNQAWAEIIKNLDFPGPIDSLPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAF5</accession>
    <name>A0A183HAF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003403">
        <property type="protein sequence ID" value="VDO40087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAF5"/>
    <dbReference type="STRING" id="387005.A0A183HAF5"/>
    <dbReference type="WBParaSite" id="OFLC_0000446601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000446601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000446601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000446601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12526" checksum="BEA4B8EA3301750E" modified="2016-09-07" version="1">MPNEAPILLPRKRRHRSQKKMVLSVECFLVAMLFVIAVQGAYLAYMVGILTNLERRFGISSKKSGALLSFYDIGHTVSVVLIGFLANDKHLPRITAIGNGMLILYYFHNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW8</accession>
    <name>A0A183HAW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS4630</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003612">
        <property type="protein sequence ID" value="VDO40559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW8"/>
    <dbReference type="STRING" id="387005.A0A183HAW8"/>
    <dbReference type="WBParaSite" id="OFLC_0000462901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="11">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="9">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO40559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="15906" checksum="D223A4235B0AB593" modified="2016-09-07" version="1">MHFLDSIIYLKLYSVCDSVEKLSNGRLGTNSTTALMGSPKSDSFSPGISSPVPCGASSIAPVGASGTPSDTSDSGLAASKKSTTRRNAWGNMSYADLITQAIVSSPEKRLTLSQVYEWMVQNVPYFRDKGDSNSSAGWKSTEIHFLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB34</accession>
    <name>A0A183HB34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4696</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003692">
        <property type="protein sequence ID" value="VDO40763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB34"/>
    <dbReference type="WBParaSite" id="OFLC_0000469501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000469501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000469501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000469501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="32946" checksum="BC1ACA5369F3D00E" modified="2016-09-07" version="1">FFIILSYHIGYSNLVTGTCPVIAEYQQQQQQQQQPQYENCSCSSASTLHAFRLTVHRQQATAVKDVACQCDSEIDSDNDGSSGSSDACGCSSDNGLFPRNPSFVSPVKIGALRKRQMGTSHSTLSCMKLLNDLGSENTPLFAGTCCDSSLSSLTQSIGQKTLECSICRNHDPVTFAGTTDITSLPVITTTVFNTDTIEQHESKSAFTSTVNNIPSRKMTLASCYDANVIRVRRLMLSRSASDSKLCIRIGPQPKLGLADIQSCETHCKDVDELNRVTADIAAENPDMIRFQQVLNSWVSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBG8</accession>
    <name>A0A183HBG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4831</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003869">
        <property type="protein sequence ID" value="VDO41192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBG8"/>
    <dbReference type="STRING" id="387005.A0A183HBG8"/>
    <dbReference type="WBParaSite" id="OFLC_0000482901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000482901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000482901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF16">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO41192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000482901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42267" checksum="40154BC3F606E379" modified="2016-09-07" version="1">MQFMPKTVHLLKERGVTFNSGFVSTPICCPSRSSILTGMYAHNHHVLTNNHNCSGNDWSVKQSKIKCIFRKNYEKNTFAVYLKNEADYKTAYFGKYLNEYTGSYIPPGWDHWMGLIRNSRFYNYTINMNGDKIKHGWDYEKDYFTDLIANDTIAFIRQLRGEDPFKPYMIVMSFPAPHGPEDPAPQYSDWFQDVETHRTEAWNYAPNPDKQWLLQHTGRMEPVHVIFTDVLHRRRLQTLQSVDSNIQRVGFRNYFKLINELRDLGDLSNTVFMYTSDHGYHLGQFGLVKGKNMPYEFDIRVPYFIRGPGFPKNISIREPVMNVDIAPTILDIAGIVIPHHMDGRSLVPLIRQYGNINSLSTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBJ6</accession>
    <name>A0A183HBJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003897">
        <property type="protein sequence ID" value="VDO41283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBJ6"/>
    <dbReference type="STRING" id="387005.A0A183HBJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000485701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000485701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000485701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000485701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36749" checksum="BDE7516F867A68F6" modified="2016-09-07" version="1">MPFQRASDTAAFSIFLHEVIRTDKFEVLIGSASAVFDSVLSYIATLKYPARRVQDALIALLDWVENKILSSAIYDDVGNVAQPESSESDGNEGARLATELLKAVMEIDEKPYESSSKPEHINLVGFHEGDHSTSIEPNDSGFHNTSNADARVTDVSLMDQSLDDLLAQLNLHQVTKFEPVFPQVGNEDSDEDDLDIVHEKKEEREEKKDTKTCEEEVQRLSDGSEIRTRKTRTFNMQQNSKQVTVRSHSNGRDEIVNTFHDGSTSFNDDLAIDDFFTTPRNSFRRNRLNGARCLNDLRKTTDNPTNLDECFSQKIKSVQHTDTVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCG1</accession>
    <name>A0A183HCG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoxygenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004304">
        <property type="protein sequence ID" value="VDO42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCG1"/>
    <dbReference type="STRING" id="387005.A0A183HCG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000517201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000517201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000517201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000517201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="42797" checksum="6300620501F3076D" modified="2016-09-07" version="1">MVLGGVNGTKLENKTLRFASPRLLSMEPDNVKDQISIFSPSLFSMHDKGEGLEALTSIPKLMKVAGNRDYEEWLNFIIEASGTTDAIQKLKEKQELDWLPPAYKSMPRGIDGQPLYFTKENVTEIDPELGRKMELYENLSYSLTSKQLEDFNTTGFSMMTPKQLMMFYGPQSPLNDSKSLEFFLSLSEDDMQRLLLDDIRKLANKHSSLKIRQKRQVTVLTPTAFGATALQARAGSLSVLSPAAFTIGALNARVLSLTLLSPSAITVGLLSPGALLLTILSPSALGLVLLGPSMLAASVLSPSTLSLSVLSPSALSANVFSPSIFTGSVLSPSCLTASAFSPSAYGLSLFSPRCLSVSYFSPSARNLVLFSPSYYTRSINSTGVNNTIMFSPSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE04</accession>
    <name>A0A183HE04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5716</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005062">
        <property type="protein sequence ID" value="VDO44079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE04"/>
    <dbReference type="WBParaSite" id="OFLC_0000571501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000571501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000571501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000571501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8178" checksum="3C24323E9E723675" modified="2016-09-07" version="1">MSKHPISSVMNQIHKLFEYAHVSVIVVTLVQVIMKQLVSLSLLPLFLYFSSRNCFRIRLLCILILIFLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HED2</accession>
    <name>A0A183HED2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5844</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005249">
        <property type="protein sequence ID" value="VDO44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HED2"/>
    <dbReference type="STRING" id="387005.A0A183HED2"/>
    <dbReference type="WBParaSite" id="OFLC_0000584301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000584301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000584301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000584301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31577" checksum="F1A53CBEC0AFF05E" modified="2016-09-07" version="1">MRNALIRIGIQHGDIVGTYLGNSSDFIAFTLAAIGIGAILVPLNPAYKTYEIEKYFKKASVKWILTEEKLFEKIRHLKKENIEAKIIILDSTEETLLYYSLQSYLSKNNSFWTNEVINDFQNKPVQEHNEAIIFFSSGTTGLPKGVILNHNTLIANVELVRKTQGIKCGKYEMVSLSGTDVVYGVLPYFHAGGLLTLFGLLGLGVTTALLVPPVLKFLAVTPNLNPEAFHSLKYLFVGSAHVKKSLIETVKRRLPKTKIIQCELSSFFFLNFLKIYCFSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEH3</accession>
    <name>A0A183HEH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5887</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005309">
        <property type="protein sequence ID" value="VDO44679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEH3"/>
    <dbReference type="WBParaSite" id="OFLC_0000588401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000588401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000588401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000588401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12369" checksum="472CA410A0BBA8A6" modified="2016-09-07" version="1">MQIGCGADVGYFFFMQVLRISVYVSLNHQIDDGLCKIKLQKPPVLNFLTIFHLILMIILFGRSLYFHQYFCSVSIPIINFIGNGTKYHALVLCKITKFHSPDPVSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HET4</accession>
    <name>A0A183HET4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5996</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005458">
        <property type="protein sequence ID" value="VDO45073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HET4"/>
    <dbReference type="STRING" id="387005.A0A183HET4"/>
    <dbReference type="WBParaSite" id="OFLC_0000599501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000599501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000599501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO45073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000599501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26326" checksum="C20B31BC61D80B0B" modified="2016-09-07" version="1">IIVKLLGRRYHLFFGIIIISVYQYLLSERNLQNWLLSDSVDRNTFIAMNREGIFSLLGYLSLYYFASAISSFMYSTGIRLKSWFYRTFQLLIIAALLFFAQKLAEILTGPPSRRIANLSYILEMLVFDTVYMAGFLLIQLASIFGWAAQMPQFSIDEGPFERLKPCMLDSVNRYGMSFFLLTNILTGVINLTITTSSVTDVYHSTAIITVYIFISCILIHVYTRLKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFR1</accession>
    <name>A0A183HFR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOT2_3_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6323</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005945">
        <property type="protein sequence ID" value="VDO46153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFR1"/>
    <dbReference type="STRING" id="387005.A0A183HFR1"/>
    <dbReference type="WBParaSite" id="OFLC_0000632201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000632201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000632201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO46153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000632201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20876" checksum="34F2D225C614F75D" modified="2016-09-07" version="1">MSEGLKKKKKETAVIPAWLGASPLGRSPAMPEHDTQLKLLEHALTRTPLPMDSEKPRSYLPKMPCVTATYYPQAPLINADTLEYYLRLSPETLFFAFYYMEGSRAQLLAAKALKKLSWRFHTKYLMWFQRHEEPKQITDDYEQGTYVYFDYEKWSQRKKEQFTFEYRYLEDKDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH6</accession>
    <name>A0A183HHH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6938</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006917">
        <property type="protein sequence ID" value="VDO48556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH6"/>
    <dbReference type="STRING" id="387005.A0A183HHH6"/>
    <dbReference type="WBParaSite" id="OFLC_0000693701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000693701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000693701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000693701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29203" checksum="5CF208894764803F" modified="2016-09-07" version="1">MSPVLVSDFYYNLCLHFIALNLGLCCNVTNNTPRCLDGTPSAGACLFGHCGAGFVCTTGNLCCLTSSIAKIISGTCPNNATSIGICINGLCPTSYTCINGQCCPQSTNTTFRCSNLNYALGPCVGNQCPDDGFQCDTTINSCCPVSEPIGTCAEPGDQCPAGSRCFKEVTTPVCFKECDDRGTISGFPVDGVCQTGTTLIFGTCCTLRTRLYNAFLSEQYADYSPESIASVIRSCPNNTEAISACINDQCGYGYQCYNNVCCPPQHTNTMLAFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHM0</accession>
    <name>A0A183HHM0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6982</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01006988">
        <property type="protein sequence ID" value="VDO48723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHM0"/>
    <dbReference type="STRING" id="387005.A0A183HHM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000698101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000698101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000698101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="225"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000698101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42741" checksum="803FA0C6ABA99BC9" modified="2016-09-07" version="1">MYHPGVTIVFSPLIALIQDQVLSCKAHGIKCDSLNSKTSVEDRRRIVEDLRATKPETQLLYITPESAATPNIQRMITSLFKRNLLNYFVVDEAHCVTHWGHDFRPDYLKLGNLRQLAPEVCWIALTATANKNAQDDIVKQLKLNNVKMFKASTFRDNLYYDVIMKDLIPSTPERHLALFIMKALGCTQKSTSITKFAPELKSAVNAVNKLNFKSGEDRHSSKSNETCGKLTFMGSGIIYCRTRDECERMATRLTEEGIPTYAYHAGLGNKMRDDIQDKWMKNVIPVIAATISFGMGIDKADVRVVVHWTCSQNLAAYYQESGRAGRDGKRSYCRIYYSRDDRQLLNFLINQDIFKTKAKKLDKKIIDEQVKAIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HII6</accession>
    <name>A0A183HII6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007515">
        <property type="protein sequence ID" value="VDO50286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HII6"/>
    <dbReference type="STRING" id="387005.A0A183HII6"/>
    <dbReference type="WBParaSite" id="OFLC_0000729701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000729701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000729701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000729701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10659" checksum="B762DF7E45FDF070" modified="2016-09-07" version="1">MDTLLDLLVAKSSTTLLIDNYTNYGLVIFDGNALWFVAGLYSGTDGKVYCNRRIEFCIDPALPLDEKFTAMFVNKIGSRVALSSAHSVFVIEIPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIQ7</accession>
    <name>A0A183HIQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cu2_monoox_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS7370</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007666">
        <property type="protein sequence ID" value="VDO50682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIQ7"/>
    <dbReference type="STRING" id="387005.A0A183HIQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000736801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000736801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000736801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO50682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000736801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16985" checksum="E17CCD3DC943D5A1" modified="2016-09-07" version="1">MGASGANEMCNFYMMFYWDATSPNPFPDGAVCASQDEQKLVSEEYPIEGTIPLHPNLEWEHQAHQSKLFGIVEGTVTTSVDGIKLGQVSALSFDSLGNLVIFHRGSRSWDFMSFGMKNSLRDKRPIAEDVILVTRSNGLNKTLVLLDKYGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJX5</accession>
    <name>A0A183HJX5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7788</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008354">
        <property type="protein sequence ID" value="VDO52502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJX5"/>
    <dbReference type="STRING" id="387005.A0A183HJX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000778601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000778601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000778601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF180">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO52502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000778601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16660" checksum="4827A3A133527175" modified="2016-09-07" version="1">MKAKIDINFHNGSGRNADLPLHISIRFDEGKIVFNTFSKGSWNNSEQRLKNYFKPNTEMDMRIRIINNKYQIFANRVEAGTFEQRAPLSGVDHISIIGDLVNLRLFHYGGRVFPVPYVAIAEVVPGKRLDISVLPTGKNDSVQKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL57</accession>
    <name>A0A183HL57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8219</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009123">
        <property type="protein sequence ID" value="VDO54621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL57"/>
    <dbReference type="WBParaSite" id="OFLC_0000821801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000821801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000821801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552560" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000821801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10433" checksum="94EBB9625827A80C" modified="2016-09-07" version="1">MKRNDGFNFKNLFISIAFLLMSFCDGERILNESCKCLSKSACKSACLNGPQKLIINHSIQKRGIDYEEVEIIDERKCNSKSLQNIMLQDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLS7</accession>
    <name>A0A183HLS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8439</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009541">
        <property type="protein sequence ID" value="VDO55648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLS7"/>
    <dbReference type="STRING" id="387005.A0A183HLS7"/>
    <dbReference type="WBParaSite" id="OFLC_0000843801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000843801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000843801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO55648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000843801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23552" checksum="65B10066FBA17E03" modified="2016-09-07" version="1">FLPDHRFPICSIHEEKKCDATGNDTRPQATSPELNKKVGQSTKSGAKIIVKDTETRSNAIPSVQKVDLAVPFSSEQPPIVTFDEWTKEKLKKEEIRKAEQQQNNQQKTIIHVDTGGTSKIDSSTISASKAAEGMAQLAPPNMISQEATARNYASKECGAKVLFSNEETENKNAILNEKEADDYMRNPCERAEHKWLIIELCETIQVGIPIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMC1</accession>
    <name>A0A183HMC1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8631</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009926">
        <property type="protein sequence ID" value="VDO56624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMC1"/>
    <dbReference type="STRING" id="387005.A0A183HMC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000863201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000863201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000863201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO56624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000863201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="16845" checksum="FA5DAC1B654CBCBC" modified="2016-09-07" version="1">MSAREIYEPTTDAESAMYGPFFGTLGVSAAMMFTAAGSACGTAKSGTGIASMAVTRPDLVMKAIIPVVMAGIVAIYGLVVAVIYAGRVTSSADGYKIYQGFSMFAGGLVCGLCGCAAGYAIGIAGDAGVRALSQQPRFFIGLILILIFAEVLGLYGMIVALILGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMN4</accession>
    <name>A0A183HMN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010132">
        <property type="protein sequence ID" value="VDO57191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMN4"/>
    <dbReference type="WBParaSite" id="OFLC_0000874501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000874501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000874501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000874501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9456" checksum="131EAEDA72F5C681" modified="2016-09-07" version="1">MNYLNEPDSLIETSTENPVFGDYDEKSWFGESGVPNLARDPIALFLELLKKPQTMGNLEALIRFSFSQNISFLFRCFYVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNK3</accession>
    <name>A0A183HNK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHRD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9065</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010749">
        <property type="protein sequence ID" value="VDO58570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNK3"/>
    <dbReference type="STRING" id="387005.A0A183HNK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000906401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000906401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000906401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000906401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11748" checksum="84195C5651E8DAAC" modified="2016-09-07" version="1">MQNDFFKLKEKNNARIFSGLEEETGIVTGTGAIPTLQIRILDGHGITGKAVTHATIGQPLTLDIVLQNTEIYDFYAHSCMAYDGSKNANAIVQIIDANGLISFIICFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNU3</accession>
    <name>A0A183HNU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010928">
        <property type="protein sequence ID" value="VDO58910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNU3"/>
    <dbReference type="STRING" id="387005.A0A183HNU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000915401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000915401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000915401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000915401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17204" checksum="38FC43C97E382ADC" modified="2016-09-07" version="1">MVIIWPARLAQRYVTTRERRKILDDVNNLIQNDKWYEALKLVIAALHDELKGEPEVPTDTGTLSLIIAVGVAVLLTIMITCCVCAFRCCGNMRSDQLDRLGKPLQRIDSLRAQIVRHGIQLRRSFSRSPKFGSFRECSLNSSFISDAGNATIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNV0</accession>
    <name>A0A183HNV0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9162</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010957">
        <property type="protein sequence ID" value="VDO58981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNV0"/>
    <dbReference type="STRING" id="387005.A0A183HNV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000916101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000916101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000916101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO58981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000916101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18127" checksum="EF9B3572DF3EACEA" modified="2016-09-07" version="1">MSLPLFFTLFSVVGLLVYWFLLLYRNDSSFNFMLFFVVLFFHSIFTLVQALGLSQYACGWINAINTFHHSIFASLIMIVSAIAFTAAFVGMVFALFRVHRFYRGAGFSLDKARKEFSDGVMTDRNVQQVLSGLHLINAFLLADASIKTLIQHREFSPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ72</accession>
    <name>A0A183HQ72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUP62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012025">
        <property type="protein sequence ID" value="VDO62028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ72"/>
    <dbReference type="STRING" id="387005.A0A183HQ72"/>
    <dbReference type="WBParaSite" id="OFLC_0000963301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000963301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000963301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000963301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="12151" checksum="39C52C44D5B05B0E" modified="2016-09-07" version="1">MILAKSTFGLSTTTGVTMPTTTTAAAPVLSFGSNIATPVVGTTTASLFGSAGSSLATATTASTAMFGTTASMATPSFAGLFGSKTTSVTTSPAVVTTSISGLNDPTTVTPSLATTANTGMFSFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQB6</accession>
    <name>A0A183HQB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9678</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012130">
        <property type="protein sequence ID" value="VDO62397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000967701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000967701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000967701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000967701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11122" checksum="7969A7EF3037BFDF" modified="2016-09-07" version="1">MPAPKGRPKARAIRRVPVVRRNVQPYPFRRRSPSRSSSSSRSRSFTTKTSSSRSSRSHSRKYKRSHRRRISHRLRRRSNSVIPLYGTSGTVIVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQX6</accession>
    <name>A0A183HQX6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9891</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012625">
        <property type="protein sequence ID" value="VDO64228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQX6"/>
    <dbReference type="STRING" id="387005.A0A183HQX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000988701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000988701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000988701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO64228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000988701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20540" checksum="6072D46855ED625C" modified="2016-09-07" version="1">MCARRQGRLREAVKMMRDLIKEFPMLNVMNIHENLIEVLLEQQAYADTQAVLARYDDISLPKSATICFTSALLKVRIVADKFTPDFVLRRGLSTAELNAVDAIHRAVEFNPHVAKYLLELKPLILPPEHLLKRGDSEAIAYSFWHLQHWKRIDGALSLLQCTWEGSMLCFYLLFNEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQY0</accession>
    <name>A0A183HQY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9892</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012629">
        <property type="protein sequence ID" value="VDO64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQY0"/>
    <dbReference type="STRING" id="387005.A0A183HQY0"/>
    <dbReference type="WBParaSite" id="OFLC_0000989101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000989101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000989101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000989101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21703" checksum="98C781B8B5CEFD4A" modified="2016-09-07" version="1">MVVSTLTNSYVYRITSSESPTLLLKLEKIEAVSSHVTTNGQNLLAIAQSSNNIIVYNTANGEQIFTGIIPEKNLAPIKLISFIETSKEFEFVVVLEDCRFLYLVGSSNKLAKEWIRHEALSAITSVEMVDLPLSEAQADIESEFASNDDTLLESLIRRLRSQLEQFRRAYISATNQIFSSNFLPFHSKSFASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR08</accession>
    <name>A0A183HR08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9921</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012687">
        <property type="protein sequence ID" value="VDO64452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR08"/>
    <dbReference type="STRING" id="387005.A0A183HR08"/>
    <dbReference type="WBParaSite" id="OFLC_0000991901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000991901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000991901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000991901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15181" checksum="24116CA670CE3D8F" modified="2016-09-07" version="1">MEQEAVFDVGNFDDRNVSLNETPRDPTHYLQQVSVSRARCPEVVTATKIPTFEVGSSALPKDLFFTTDPPSEQSIAMSKRFSMQRAFIRNQRSKWKEEAINFKWPGLVSCLFAFCSTVQHRLLVFSLIEKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS50</accession>
    <name>A0A183HS50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013601">
        <property type="protein sequence ID" value="VDO67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS50"/>
    <dbReference type="WBParaSite" id="OFLC_0001031101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001031101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001031101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001031101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12770" checksum="CA5F3C135A231E8D" modified="2016-09-07" version="1">MEHHWSPVQAILFGSEKPFKRVCITRPCFVLMVTSEKDHLIIIERFVRDKNIPFVSEKSSMDGFIIPWTCFTSLDIKLNAFSIRDINKNKPISTYGPLNTRKVSLLEIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSQ5</accession>
    <name>A0A183HSQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10515</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014084">
        <property type="protein sequence ID" value="VDO69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001051601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001051601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001051601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001051601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="10903" checksum="ED2E562761F0284F" modified="2016-09-07" version="1">MIHRIISDAQLAVLGPETNALPAGNFFLNRETAAIFAAASPFANIPVTTENGILSNSQTVCSGYMDIPSKTVSDGFAALSNIQPRSDGSNIAISCDTSKVMGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT89</accession>
    <name>A0A183HT89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10701</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014542">
        <property type="protein sequence ID" value="VDO70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT89"/>
    <dbReference type="WBParaSite" id="OFLC_0001070101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001070101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001070101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001070101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3616" checksum="05172974A08C666B" modified="2016-09-07" version="1">MQINRTYKFTRRKGYRKVDSSGSKTSSNFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTC0</accession>
    <name>A0A183HTC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10736</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014648">
        <property type="protein sequence ID" value="VDO70915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTC0"/>
    <dbReference type="STRING" id="387005.A0A183HTC0"/>
    <dbReference type="WBParaSite" id="OFLC_0001073201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001073201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001073201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001073201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13142" checksum="5E260BA211698AD3" modified="2016-09-07" version="1">MFEYDRLALDVAEQFAQIRSNAIASSPTQIFDPFRTVSGLCFSPSGSDVPDCGTSSGYGSPGTGETPLSSPAPQVFSLPSHVQHALCDPETCDDFENVAASLGPTVIYNEHNKKVLRKFQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTL7</accession>
    <name>A0A183HTL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10833</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014900">
        <property type="protein sequence ID" value="VDO71704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTL7"/>
    <dbReference type="STRING" id="387005.A0A183HTL7"/>
    <dbReference type="WBParaSite" id="OFLC_0001082901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001082901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001082901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026074">
        <property type="entry name" value="MAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF12">
        <property type="entry name" value="ATPASE F1_V1_A1 COMPLEX ALPHA_BETA SUBUNIT NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001082901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14849" checksum="6E56CEFE0FC022D5" modified="2016-09-07" version="1">MIVLNPERNSKDLTSLLHALKTDENIEKFAALTSLAFLLVWYPSDHTMPVSRILITGACSLEKLYASLEKLKNEEYLRHPKFTQVMKEKSSTARPGKMIRKLVPTKNLPNSSSRPASLQTATLSAPGEPLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTN1</accession>
    <name>A0A183HTN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">H15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10844</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014921">
        <property type="protein sequence ID" value="VDO71759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTN1"/>
    <dbReference type="STRING" id="387005.A0A183HTN1"/>
    <dbReference type="WBParaSite" id="OFLC_0001084301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001084301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001084301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001084301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11328" checksum="21B8D07CD698EF80" modified="2016-09-07" version="1">MPATEEVIAAPSAATGDNLAVVVPSNTSASLTAPSGKKRNMIAKMNVTVPKSMKSHAKSQHNHPPYGNMIKAALMATQDKKGSSRAAILKYIMQNFAVGENPTMVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU23</accession>
    <name>A0A183HU23_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calsequestrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS10988</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the calsequestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015298">
        <property type="protein sequence ID" value="VDO72898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU23"/>
    <dbReference type="STRING" id="387005.A0A183HU23"/>
    <dbReference type="WBParaSite" id="OFLC_0001098501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001098501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001098501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051279">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000346">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001393">
        <property type="entry name" value="Calsequestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033:SF0">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01216">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO72898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001098501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17603" checksum="A029FA71EEE6622D" modified="2016-09-07" version="1">MGEVEFYAVVNSYWARKMGLKRVGEVQMIRPFEDDPIYAPTSVDTEGEFESWVEKHKQPIMQKLTLQNYFNVWKDREDDEKLIIAFCDEESREGRAMFKLLQKIADENSEHAGTLKISLIDPDEFPLMVDIWEEMFGIDIEGGPQLDRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU84</accession>
    <name>A0A183HU84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11046</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015434">
        <property type="protein sequence ID" value="VDO73383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU84"/>
    <dbReference type="STRING" id="387005.A0A183HU84"/>
    <dbReference type="WBParaSite" id="OFLC_0001104601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001104601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001104601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001104601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4401" checksum="D8AB8E266905BC05" modified="2016-09-07" version="1">MYQTRYSELVDYTYDWPEHDMVQGYPVPYEEEHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVR1</accession>
    <name>A0A183HVR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016861">
        <property type="protein sequence ID" value="VDO77438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVR1"/>
    <dbReference type="STRING" id="387005.A0A183HVR1"/>
    <dbReference type="WBParaSite" id="OFLC_0001157301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001157301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001157301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF12">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001157301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26958" checksum="0F15A7659358FFE8" modified="2016-09-07" version="1">MLPYPTHLDHNPLPPQQSISQQPTLALLQQQQFPPYMHSSLEQRFPTVIQAVTIQPPTNFRNLLLENITDQQIYQQQTPLILNTIPNVGQQTVSDQLFPLWKPFQSIDRSLLNAEKRLKKCCSRLNNADSECKRRFCNFDALEPRMVLFYLSICQPRGPTVGQMWDCASSRQNHTSCCIKKGVSPICQIYCETTNGVPTDYTKYLLCLSNFRQIRDCFREHLETHHNLYGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVV3</accession>
    <name>A0A183HVV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AP-1 complex subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11615</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017014">
        <property type="protein sequence ID" value="VDO77877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVV3"/>
    <dbReference type="STRING" id="387005.A0A183HVV3"/>
    <dbReference type="WBParaSite" id="OFLC_0001161501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001161501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001161501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO77877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001161501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20653" checksum="A26006D0BD46E03E" modified="2016-09-07" version="1">MPVLVYSDWGFVQLQLLTAVVKLFLKRPSETQQLVQRVLSLTTQDSDNPDLRDRGYIYWRLLSADPAAAKEVVLAEKPLISEETDLLEPSLLDQLVGHIGSLASVYHKPPSSFVDITKHPLKTTNVAAGLVLNYLHNLLFSFRVCIHFTLYKTYFENFYKNLNLMTNSLVKKVKRLHNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWM1</accession>
    <name>A0A183HWM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11882</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017759">
        <property type="protein sequence ID" value="VDO80090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWM1"/>
    <dbReference type="STRING" id="387005.A0A183HWM1"/>
    <dbReference type="WBParaSite" id="OFLC_0001188301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001188301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001188301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001188301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7128" checksum="CB747867DF41840F" modified="2016-09-07" version="1">MKRNQQIKMFWRRLYMEDKKLKILVLDVDDEDFVENLKDCLEAFQSNIHPILIPSGSSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXP0</accession>
    <name>A0A183HXP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018790">
        <property type="protein sequence ID" value="VDO83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXP0"/>
    <dbReference type="STRING" id="387005.A0A183HXP0"/>
    <dbReference type="WBParaSite" id="OFLC_0001225301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001225301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001225301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001225301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9763" checksum="7936F656B8ECEBF3" modified="2016-09-07" version="1">MELRIQKGMELRQRNVSRDVNGARNGAEKDMMKDFKVDLIDKVFFLPSFHTVFFYHFNVTCQNYHKSYQSVEFSQLFYVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY64</accession>
    <name>A0A183HY64_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">OFLC_LOCUS12426</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="EMBL" id="UZAJ01039840">
        <property type="protein sequence ID" value="VDP11291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY64"/>
    <dbReference type="STRING" id="387005.A0A183HY64"/>
    <dbReference type="WBParaSite" id="OFLC_0001242701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001242701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001242701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF24">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="22">
        <location>
            <begin position="31"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="23">
        <location>
            <begin position="471"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="VDP11291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001242701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="580" mass="66350" checksum="B329EE147EEC08CC" modified="2016-09-07" version="1">MQSGLVLLIRVKWDIWIHMKMNEPLHQIFLRNVKNYRDKEALIEVDTGRRLTFHEMNQLCNQYANYFQSQGYKNGDVIALFLQNCADFPAIWLGLSKIGVVTSWVNINLRAEPLAYSITISKSTSIITSNELFPALEDMFLSGKLERMKVYIIDDIGNKKNGILSLATKIPLISSEEPVVNEKPTFRSVLCYIFTSGTTGNPKPALIKHYRYYWMAIGVAKSFGIFTTDRLYVMMPAYHSAGGMLGIGQTVLQGSTCVIRKKFSASYFWKDCVKYNCNVTQYIGEICRYLLMQKEIVEAKEHKIRLMFGNGLRAEIWSEFVNRFGIQKIGEFYGSTEGNSSIVNIDNHIGACGFIPVHPFVKYLYPVRLLKINDDTGELIRTKDGFCVACKPGETGEIVAVIKKNQPLLNFDGYLDEKDTGKKIIRNVLCKGDAVFTSGDIMHWDDLGYLYFKDRKGDTYRWKGENVSTTEVEGILQLLKCVNDVVVYGVKIPNREGRAGMAAIVLERDEFLEDVIHKIAEHFKKSLPSYAIPIFLRFCKNFERTGTYKLKKMRLQKEGYDLSDLNNQIYIWDSSIKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY91</accession>
    <name>A0A183HY91_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitotic spindle assembly checkpoint protein MAD2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic arrest deficient 2-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS12453</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039846">
        <property type="protein sequence ID" value="VDP11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY91"/>
    <dbReference type="STRING" id="387005.A0A183HY91"/>
    <dbReference type="WBParaSite" id="OFLC_0001245401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001245401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001245401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990728">
        <property type="term" value="C:mitotic spindle assembly checkpoint MAD1-MAD2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="9">
        <location>
            <begin position="14"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001245401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25461" checksum="EA55A53E2F9656FE" modified="2016-09-07" version="1">MATDTKIRDVICLKGSAQLVQEFFHFGLNSILYQRGIYPADSFIREKKYGLTMLVTNNPELQKFLAPLLEQVKHWLESKQLRKLVVVISNIQTKDVLERWQFDIDTDPNIQQYGYFDIIFVRSKGDYFSENSTRQKDEKKIRQEMADVIRQITASVTFLPLLETQCSFDVLIYTGKETDTPEDWTESSACVINDAEQVQLRSFSTAVHSVHTKVSYKPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYP8</accession>
    <name>A0A183HYP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12610</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039882">
        <property type="protein sequence ID" value="VDP11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYP8"/>
    <dbReference type="STRING" id="387005.A0A183HYP8"/>
    <dbReference type="WBParaSite" id="OFLC_0001261101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58708" checksum="46624E8B2B4B5D5A" modified="2016-09-07" version="1">MYLFCVLIIVSIILFVIFSFHCIFSFHCDGIFRFLEDFVPEKWLGRGGYGVVFKCRNRLDDRNYAVKRIAVSNTTAAIDHVKREARAMARLDHPGIIRYFHTWMEKPPSGWQQTKDKEILQNICSVEDSGNKSIIHTLESERGIIQSKNLKDKACDSSLSEELLNGLNLNMSIKEKGVTVSGNTQNLSWMSDDNGNELRAATVLDSSSFDDDSESIEHGITALASNFFFKNFLCTSFSAGSDDSAGIIFAHCGNCLRTTEELEEEKSKNSKLLDPLEPPAVLVTSMCDLQNCKNIKDYVYLYIQMELCQELTLHSWLLANNKNEDREITQMRKWLAELVCAIDYIHSQGLIHRDLKPQNIFFSADNYLKIGDLGLVTNYVTAEERTDCEQDIITNVSHTSHVGTRLYMSPEQLKGKPYNEKIDVFSLGLIFVELIVPFTTTMERHSILFGLQNDIMPKCLDNLPSEEKKFVAWLTVVDPELRPSARQLAECDYLRDEVLMLGTSYFREHIFSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYX9</accession>
    <name>A0A183HYX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cofactor of BRCA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039906">
        <property type="protein sequence ID" value="VDP11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYX9"/>
    <dbReference type="STRING" id="387005.A0A183HYX9"/>
    <dbReference type="WBParaSite" id="OFLC_0001269201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001269201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001269201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001269201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="649" mass="73955" checksum="384822AE5DBF5941" modified="2016-09-07" version="1">MGFKMRGIRVSMEKRWVTDLENQNIDGSRRLRHLLMTCADPIETIKNFQERNSIKLPVLNPALRLLDLHNIRRTEFHEEAANDISDLLLTKIKDLGATGTIESVQLLEKQLEKSFKLYRVPSIRPFVLETLKQLPKAPDRYLKVIVTDREFYDNCAVTVRQQIWLKNDSLYMDAILPVIDSYIDEKQKVMQIVDQSPTNYFTCETTKSRRQWPQILELMAMVGQQEPLYRRLNSVIRERFLKSADATYCSLRMELVMSAHDLNIESVIRSDPCHDLAWCLDACVRDKHLDAQQTNKLKNILDSTKKLKAEIIGDLAMIAGDAHVIHFLCSMAVKVLRDSALHATGHLPRELVPLQLLLRLLSFGASAHNILSTNDVTVLQNVDALVFTKFLASFTTLIVEDVIRYELNRASDEIIDENPASDFLSDPSEEMLSFLKTDVTCALLWIHYLLDVLPSKRRVSDLPGIMRYLKALPRLKCKIAFCDPWIHLVIHRLLQSAPFDHLLSTEQASHFIIEEYLLKGLDRCPGVKYHLLRIVHLLWSSIGDFRCRLILDKIAPEKVFESGDPDVEIDLKRYTQEYQRIRTKMTEKSSSTDGSISSASVTSMQSISNASVTSTQSISSVSVTSMQSISSASVTSMQSVSDTTQTVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ38</accession>
    <name>A0A183HZ38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epimerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12755</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039924">
        <property type="protein sequence ID" value="VDP12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ38"/>
    <dbReference type="STRING" id="387005.A0A183HZ38"/>
    <dbReference type="WBParaSite" id="OFLC_0001275101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001275101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001275101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000336">
        <property type="entry name" value="Aldehyde reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001275101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40592" checksum="6F28B43D4C3E6F58" modified="2016-09-07" version="1">MTETMKTNQNIKVLVTGASGFIGIHCVQQLLKENYTVRGTIRDLNNHVKVEPLKQLEGAAERLELVEADLESDQGWSQATTDCTYVLHVASPFPIVTDESVISTAVDGTLRVLRAVAKSSVKKVVLTSSCCAINEGHEDMTRTFDENDWSNIDSTNINNYIKSKTLAEKAAWDFVDKEDVKFKLTVINPALVVGPLLHNERGTSIDVIRRFLNNEVPAVPVVQFGLVDVRDVAKAHIHAMREPRSDGLRILMSYQPSFWFMDIANVLRDEFSSQGYIFPRFTVPYPIIWFYSLFSKETKEQVLTRYGNEVHFDNSLAKDILGIEFINPKESIVAMAYDIIERGMAPKRKNYRRPSVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I054</accession>
    <name>A0A183I054_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040052">
        <property type="protein sequence ID" value="VDP12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I054"/>
    <dbReference type="STRING" id="387005.A0A183I054"/>
    <dbReference type="WBParaSite" id="OFLC_0001311701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001311701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001311701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001311701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36145" checksum="8180249C2FCCB461" modified="2016-09-07" version="1">MNNRCFTNTSLVKSPTSSNNTKNANYVNPVTTYAYIHLKNCSSTHSLGSSSASLCSSITSSSTTLDHPLTENLSSKNSCLIPPPIFFGESIMLLGKYILNQPLTPADVHEILNVKEKEWNNKTVLPDTVDLTDTDRTFLSFYSSSTSPIFDSSVPKPLPRRRNFHGIPPEIDRSCKPTGVRYIAINTGQERWPCLTDRGVGHNHLQKINNRKKEAFAASSRFLPTNPSHQQSLHSIELRNKQISVDQETLYDNKSVTTMNGVLDYFDPMIEPLAQSQSFIKSFQRPKICCTTEYAQIDEESTKAVLEANVQQDEMRHYGFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0N7</accession>
    <name>A0A183I0N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SEC14-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13299</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040132">
        <property type="protein sequence ID" value="VDP13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0N7"/>
    <dbReference type="STRING" id="387005.A0A183I0N7"/>
    <dbReference type="WBParaSite" id="OFLC_0001330001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001330001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001330001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF66">
        <property type="entry name" value="PROTEIN REAL-TIME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="299"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="480"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001330001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="656" mass="74899" checksum="F5BA347BBC1B1987" modified="2016-09-07" version="1">MVQTYQSPVRIYKYPFEMVMAAYEKRFPTCPQIPIFVGSEITYEYHSEDGAEEVIERKCQLNIDAPYLVKKIAGVDYVYFAQKNSLDRRKRTLIIEARNISFTTRIDVKETCFYYVHPENNDWTCFEQSGSLDVKSFFGFESTVEKLAVKQYAANLAKGKEVLEYFINELIKSGVTFIPPYSDATESVSDSAIDISRLADEEEKEKDKVDTKVEEQRKPSSQTRRFSLAKKSSIGLLPRKSINSIDDLFRGGKLPNDAHLLRFLRARDFDVARASDMVQKSIKWRKQHNVDKILQEFEAPPILKQFFPGCWHHNDKEGRPVFVLRLGKLDIKGLLRTCGMQTIMKFTLSIIEQGLIKTAKATKMLGAPISTWTLLVDLEGLSMRHLWRPGIQALLRIIEVAEAHYPETMGLVLIARAPRVFPVLWTLISPFIDENTRKKFMINAGEPVISELRKYIEQQYIPEFLGGTCSCMAPEGGHIPKSLYKPVEETVIEDDVLKSTYQSANIYKGTPHEVIVRVTAEGCVLTWDFDILKGECEFLIYYTEKQVEAANIPNSPSVLSSVERVTAAIGSTVTNSVLLCDPKLTIGVNLKLEEKPVQFTEGDSMQGSHYCPQAGYYILQWRHLEAVQNQPFDFSLSGHKCKIMYYHELLDSLDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I136</accession>
    <name>A0A183I136_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13448</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040205">
        <property type="protein sequence ID" value="VDP13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I136"/>
    <dbReference type="WBParaSite" id="OFLC_0001344901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001344901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001344901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001344901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9611" checksum="00FE73A123EB7EC2" modified="2016-09-07" version="1">MNRIKGGQRATLFAPTTRKAHRGAGILPAGKTERPKFSRVDGWVRHVVCACACVHVAGRDRPGVACLGEENDVDSVKNSMDEANGTVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1P1</accession>
    <name>A0A183I1P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Laminin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13653</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040317">
        <property type="protein sequence ID" value="VDP14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1P1"/>
    <dbReference type="STRING" id="387005.A0A183I1P1"/>
    <dbReference type="WBParaSite" id="OFLC_0001365401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001365401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001365401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001365401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28610" checksum="E2CC6E7132005B41" modified="2016-09-07" version="1">MIKTLFRYCSLRENAMGVMEEVCNICDASSKTRSHPASYLTDLNNLQNVTCWVSEPSTDYPYNVTLTLSLRKKYELTYISVQFCNRLADSMAFYKSVDFGKTWMPFQFYSTECQKIYDRNPNIKIGKHNEQEALCTNTHALTSVPNRVAFATLENRPSAFEFEHSPVLQDWITATDIRVVFNRLSPDQVTIDFIPVIIMCEYFYISPGADCERCKTFHLDRPWGRATSENANHCVGKSFLQFFLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1X2</accession>
    <name>A0A183I1X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13734</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040364">
        <property type="protein sequence ID" value="VDP14523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1X2"/>
    <dbReference type="STRING" id="387005.A0A183I1X2"/>
    <dbReference type="WBParaSite" id="OFLC_0001373501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001373501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001373501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001373501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31473" checksum="DEDB704E5009DDB5" modified="2016-09-07" version="1">MHLSVNQMEQTITLNGHIYMWSRIEIYPTFSIKIGCKFDYSAYPIDTQICALGIYTTDRMSQVQLSVYYNMQPTVLLGWGSQSNKKHISDWMIESVTMNVSYFNGGNYKTEKPTDIEELDVTWSILYTWLTLHRNASSFTLTLLLPALISYMFIIFSFFLPSPDSAIYILLANLFFIGVFLEDLTIMIPPAIGKLPKIVWFIGINLVLTMVAIFLHLWLRYLLKREDHVTRWYLHVLHVKRIIPKRWRTTLLDNIPSNSGIEENATNTGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I312</accession>
    <name>A0A183I312_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14124</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040613">
        <property type="protein sequence ID" value="VDP15576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I312"/>
    <dbReference type="STRING" id="387005.A0A183I312"/>
    <dbReference type="WBParaSite" id="OFLC_0001413201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001413201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001413201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001413201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21134" checksum="31FAC52973DABCF7" modified="2016-09-07" version="1">MLSSNELEEISSGDGMCDGAIISASMLTDRRPSAAETMTNEIIFQHQILRPGQSNTAMRVPSMRELSEICANNLTGRLPVFDDVEKNPEKVGWIGEPISHPLALIRGPSGTFAVSKNVVIIGRNCANSITDLVVQESNYISRCHVVLHYTGQPNGWNIKVNGKNGVLINEVMYERSEQAQSIPFRYILIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3C8</accession>
    <name>A0A183I3C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14240</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040699">
        <property type="protein sequence ID" value="VDP16143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3C8"/>
    <dbReference type="STRING" id="387005.A0A183I3C8"/>
    <dbReference type="WBParaSite" id="OFLC_0001424801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001424801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001424801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552749" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001424801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14179" checksum="BC51C2A3B3DA479E" modified="2016-09-07" version="1">MKFGTAQLLGCILLAPIIVSQERHKEKDDAYIDLIPLNLIPEGCSLNSYYGYGIVDGSLEKCDKYSEAKTKGEKFSSEYEEIKCRTLRMHGRMKNNRCECKPGWKGPICNEYYGCPTGYSLYNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I496</accession>
    <name>A0A183I496_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L13a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14558</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040956">
        <property type="protein sequence ID" value="VDP17607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I496"/>
    <dbReference type="STRING" id="387005.A0A183I496"/>
    <dbReference type="WBParaSite" id="OFLC_0001456601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001456601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001456601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP17607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001456601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37626" checksum="1715DF09EF6B85DC" modified="2016-09-07" version="1">MSFLRKRCNVKPARGPYHFRAPSRIFWRTVRGMLPHKTHRGKAALLRLKAFDGIPQPYDRVKRQSAAFYQHKKMKSKLLTEALKSEVVKNSPYQKLIESYGYHLLDEKAFDCNIIVIKCDDLSSPAFLQLCIVDYALKKNMKVVYISATRSMLAFKTVANKMMIRLSGKLKFLLMSQFLPNGFINDNDNTFFAYLLEEINKQIDENDKEVFIICDNFAVFCDFTSTSSHILTFIRRLQQFRKNLEIKLVLTFQSKDQICNIILHESDIIIRIKRVGNGFAKDITGQLCVMEHNGKAPYTENIFNYHLSDRSARLFLPGMSRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4K1</accession>
    <name>A0A183I4K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041056">
        <property type="protein sequence ID" value="VDP18103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4K1"/>
    <dbReference type="WBParaSite" id="OFLC_0001467401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001467401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001467401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001467401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6341" checksum="4ECAB52F36B571DA" modified="2016-09-07" version="1">MLLVTARLVGNDEPQKSNTTHRRSDTTSYACSESAIPLSERVVELIFKSGLAFKDGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4U8</accession>
    <name>A0A183I4U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041167">
        <property type="protein sequence ID" value="VDP18638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4U8"/>
    <dbReference type="WBParaSite" id="OFLC_0001477101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001477101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001477101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001477101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7608" checksum="9D664DF13A2AAE05" modified="2016-09-07" version="1">MEKFGLRLANGTQIGNALNKKNLQDIESTGLFVTSRNGDINDAMSVPVCPRLTTSKRKSSMPSNSPNLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I544</accession>
    <name>A0A183I544_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14856</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041285">
        <property type="protein sequence ID" value="VDP19248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001486701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001486701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001486701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001486701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8002" checksum="3C215FE23FD0DFF1" modified="2016-09-07" version="1">MISLPSANCSCISSGIRVAARRLRKIMGXXXXSANCSCISSGIRVAARRLRKIMGYEVHLVCGVFTCSPRVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5H8</accession>
    <name>A0A183I5H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041456">
        <property type="protein sequence ID" value="VDP19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5H8"/>
    <dbReference type="STRING" id="387005.A0A183I5H8"/>
    <dbReference type="WBParaSite" id="OFLC_0001500101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001500101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001500101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001500101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9504" checksum="D6039E70CA09E069" modified="2016-09-07" version="1">MTTPVRKCMSWDFRTYACPRVCALLLDFIWSDILGNWFRHRSRSRCASIEGKTCRESIEKFVTYTIPPSVEAVMEKVVFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5S6</accession>
    <name>A0A183I5S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15088</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041594">
        <property type="protein sequence ID" value="VDP20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5S6"/>
    <dbReference type="STRING" id="387005.A0A183I5S6"/>
    <dbReference type="WBParaSite" id="OFLC_0001509901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001509901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001509901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001509901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="33036" checksum="554E6F4DD6553E85" modified="2016-09-07" version="1">MRPLVLSTGLMTRAQSTADEVETATKWWNDYPTSRYVDLARPETTFQNYMSNVWSKPKQIARSASYTNLTYIKRDSGNFNRIQDSENLINSKETEHDFPIRRSTSISSLAPSLALPQHYRQAERIIDTARVYQPRIYNWYNNSYSKARWIDTHETVAKPLRRPTFEPMPYSSYVPYYTFQTKRIFFKERMQPLKSYIAESQKYLDRYVSARLKADDFAQQYAYTSYDWRYPQDHAFNRHFMYGEGVYMPHAPRIPHSYNDAQALRKLYITTGRFRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5U3</accession>
    <name>A0A183I5U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041619">
        <property type="protein sequence ID" value="VDP20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5U3"/>
    <dbReference type="STRING" id="387005.A0A183I5U3"/>
    <dbReference type="WBParaSite" id="OFLC_0001511601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001511601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001511601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001511601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29593" checksum="5D6933800D4FB123" modified="2016-09-07" version="1">MSDMGREHCSALVPYAKPTILREFSTDHRTVTIGERTFRLRQNWQQNGVAGVIWDSGIVLARYISEHPELVANRTVLELGAGLGLPSILSSYHNAKIIHATDRISAISLLEENIRRNANNDCDIEIFAFDWNVDKLPQKYQIILGADLIYGGITFESLIKLFRDASDSNTVIYLCSKIRYQRDQDFYDQLLREHFDVREIFYETEFAVNIFEIKKLTSYCNKIICNAFSFTEFLFEYRKKFILSMCWNRTQMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I720</accession>
    <name>A0A183I720_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSP1_CCN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15532</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042311">
        <property type="protein sequence ID" value="VDP22396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I720"/>
    <dbReference type="STRING" id="387005.A0A183I720"/>
    <dbReference type="WBParaSite" id="OFLC_0001554501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001554501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001554501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043973">
        <property type="entry name" value="TSP1_CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF20">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19035">
        <property type="entry name" value="TSP1_CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="CCN TSP1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP22396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001554501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15194" checksum="C54FC3A916840DA0" modified="2016-09-07" version="1">MAQAPFSAAWNDKQHIQNDDFASSTFDMDADSGVGAGPIGIGGGGSNGIIGTQPRFFPGQWGQCSTTCGPGVATRTVECSPKPNAFQPCQVQPCTLNEAGNDIPVRERSLTSTRSFKWDYSDWTACSASCLGGIISFYLLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I751</accession>
    <name>A0A183I751_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042370">
        <property type="protein sequence ID" value="VDP22592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I751"/>
    <dbReference type="STRING" id="387005.A0A183I751"/>
    <dbReference type="WBParaSite" id="OFLC_0001557601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001557601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001557601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001557601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19249" checksum="113BCAC808BE2D11" modified="2016-09-07" version="1">MKYRLFYNENVEYLFFFSGRPTEIDESDVYVVESKVRGYEDGGKRCSLTGCKSSHYSSTKVANDCAVVSTNEQKISLKVDMDQLPSTAKTKTEDFHSNVPSTSKGIIEQSGTITKLGSMSASFSSISVDDDSSSGSNQAASTMRNTPISVDQEEAMNDAYAKKLKHSLKVDYSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7V0</accession>
    <name>A0A183I7V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15812</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042943">
        <property type="protein sequence ID" value="VDP24035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7V0"/>
    <dbReference type="WBParaSite" id="OFLC_0001582501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001582501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001582501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001582501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6988" checksum="8BE5E55EC98E76AC" modified="2016-09-07" version="1">MMDAKIAVIQCARQWPLYFSVQFPVVDQFINRVTNEVVNAHRILTVHETGLAALDSGNSFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I827</accession>
    <name>A0A183I827_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Runt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15889</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043141">
        <property type="protein sequence ID" value="VDP24583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I827"/>
    <dbReference type="WBParaSite" id="OFLC_0001590201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001590201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001590201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="5">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP24583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001590201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16277" checksum="2B62D0CAC43C8494" modified="2016-09-07" version="1">MDTNDYEKTLIALEETLATITTTTKLLPTGCPNVICTALPNHWRSNKSLPLPFTVFAFEPVPDGTIVTVAAGNQENCCADLRNNRAQMNGQIARFNDLRFVGKSGRGKIFQLFFSXXXXMIYDLLVKVDEVKFFNSFFPKKKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I857</accession>
    <name>A0A183I857_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15918</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043247">
        <property type="protein sequence ID" value="VDP24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I857"/>
    <dbReference type="STRING" id="387005.A0A183I857"/>
    <dbReference type="WBParaSite" id="OFLC_0001593201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001593201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001593201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001593201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23980" checksum="252367D4BDDAA27B" modified="2016-09-07" version="1">IQQSFLHALNGLFSCARKKTSKTPQRRNRSHSWSPSYDGTGNFLSEEERRLRWAFRKNQPDFPSSETRRKKQFFSPVGEAYSIALKQKKKNKVAKCSCNYDKLARKKSSGRTSAFTICSSEQSTSSTMKPLKSENGGNTTYLTAPEYNTRGENGSSCSRNSSNTTYILSQEMESLKLGLTSLQVSSIKIPQKILAVVRQLSDERLKQELSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8J6</accession>
    <name>A0A183I8J6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16058</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043826">
        <property type="protein sequence ID" value="VDP26596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8J6"/>
    <dbReference type="WBParaSite" id="OFLC_0001607101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001607101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001607101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001607101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9738" checksum="9DDF93CB2D1EC8B3" modified="2016-09-07" version="1">MSWKEFLSTDPPFSETVIVSPLRRLESKETHRFIPGVDSFETSRWRGSQSRRCLDVRVGYWSGLPCPSPGDLPGPGMEPGSPASQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8K5</accession>
    <name>A0A183I8K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16067</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043902">
        <property type="protein sequence ID" value="VDP26733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8K5"/>
    <dbReference type="WBParaSite" id="OFLC_0001608001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001608001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001608001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001608001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3418" checksum="6DF40D9200FD64EA" modified="2016-09-07" version="1">MLGTNEAELPRRESNEWQCLQVPGSSTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TU35</accession>
    <name>A0A3P7TU35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000090">
        <property type="protein sequence ID" value="VDO25336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYK0"/>
    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF4">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="406" mass="47161" checksum="4800F2CD2C0C4D58" modified="2026-01-28" version="1">MIIRSYWLSLIILSLPSVFTNVIWLDMDNHDGIIKSAQVVFVAFCADWCPFSRRLRPVFEEAAATFAQENPTANVIWALVDSVEQAKIADKYSVSKYPTMKVFINGELANKEYRSTRSVEALTEFVKRQLSSSIKDFANKKDLEQQMDKSKRNVIAYFADKNSDEYRSFQKIATILREDCAFWVGINEDLKAVSGSMMHFRDPDTEDEQKFTGNFTDYNYVKQWLTDKCIPLVREVTFENVEELTEEGLPFLLFFRNPENKEDDKKFTELVMRELYDQKNTVNALLADGHKFAHPLKHLGKTEDDLPVLAIDSFQHMFLFDNMNELYVPGKLRQFVLDLNSGKLHKEFHEKMDQEMLDLQNLALKKLETFAESNVKPSTFATPPPSIFKELKPSENRYSLLRKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UTK6</accession>
    <name>A0A3P7UTK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000108">
        <property type="protein sequence ID" value="VDO25487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GYN8"/>
    <dbReference type="OrthoDB" id="6285520at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="358" mass="38424" checksum="04AE5B405E7B4610" modified="2026-01-28" version="1">MLSRLFCTSSSLQLPNNFATAFRYFSKTTYNTARYAGRRVAEGNYGFGSATRTTLKERLMGPTTGKPYMYGSAAVAGASLLGIGALCYYGLGLSKEGQSILVQSGTWPAYVRDRIKATYGYLFASLGITAASAVAASRSFQISRLIMGSPFISMAVVMASSIAVSLIDYDNTLLKHAAWILHAGLMGAFIGPVCLMGGPLAMRAAWYTAAIVAGLSTVAFTAPSEKFLMMGGALAMALGVVFASSIGTFFLPPTSTLGASLMSISLYGGLILFSLFLLFDTQFVIKRAKMYPISGTSEEQIYKPGYYGNIGAGYYDFVAPKMRRFDPINAQLSIYADVLNIFIRMATIMMGMQGGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UV43</accession>
    <name>A0A3P7UV43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS26</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000006">
        <property type="protein sequence ID" value="VDO24253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GXR6"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="322" mass="35743" checksum="D39B7B0E78E4B1C6" modified="2026-01-28" version="1">MLIFVVLLTYFVNDVFGKLCPKIFGQFECPLNSTCTINECYFDNKAIAPNNCEQVKCSADSRCYKGRCYPTIGLPCDRNVELSKYQFKSITSNCGQNGKCVNGRCVEDRCAGVICTENEMCQDGKCSVVTNTFCITHFDCGPLFKCQRNKCVPFRKPVPCNCDPGEICKQGHCVPEPDCAHLTCETGSFCLQGKCQTAIGRDCTDMVCQGDTICVEGKCILDPCTNRCPSEHACCEGQCRHFQGLLCHRECPKPYVCIDGRCMRNECSGKTCQPGETCQNGFCIKVEGRLCNLAIRDCAEDFECIEHVCHDLLINTTNSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UXS4</accession>
    <name>A0A3P7UXS4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003265">
        <property type="protein sequence ID" value="VDO39726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UXS4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO39726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="352" mass="39887" checksum="5CD0C6DE8B7A2463" modified="2019-02-13" version="1">MLFKGKTEYLIKWKGWSNQHNTWEPSSNILNENLFTESGFSIPSDFKGGTRKGSRRSNRGRKRKVKEISDSDDDSEGGNQSYEDEGASESRSEASEVSPKSSIHSRSETPVPLTEEPESSKPSKMPRKRGPKSKKVLNDMPTTSISVSKISEIKNNEDKIELKEKKLDEEQEVGESLEMEIEKELDKKEETKSKSITSETKLNLLDTDKVEKDDSELSEGEIFRIIKDNESGPVEEKNAKQEVQIKLKKPEVFEGRSGSVQVVSNGQEQIINRLAFVVEGTSGLSRSSEQLQLHDYGDNDESRIRVITDQLKNETKIWTDINNTRFESFQYNGSHTITEVTVNQHTVPIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VKQ7</accession>
    <name>A0A3P7VKQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002116">
        <property type="protein sequence ID" value="VDO35817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H6Y8"/>
    <dbReference type="OrthoDB" id="8914197at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="191" mass="22568" checksum="DF38C10C31BCF88B" modified="2026-01-28" version="1">MSLRFGPRAAGSDGTDFKHRQRIAAHYHYSAQYKMYLKILFGLHLLVLLTMWAKVGGEVLVEEFGIQWRFYETLQLPSAYPWEYVWCFSFIPLIFALLSFKRNKINLLRNHYYGQFIMGILPCSIGVGGQLPELIDYLRDMKNSQTPTFRGTFPMVIIWYIFFLVALQIHIFAMYFSYHLMTAWQPPKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VVL6</accession>
    <name>A0A3P7VVL6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13 second N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001981">
        <property type="protein sequence ID" value="VDO35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VVL6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="64354" checksum="2F6B7C125DAE2B22" modified="2019-02-13" version="1">MQRQLLNYWGLSGDSTSEQSWWGASLVSTIVNNIQLILTNVHIRYEDDMTLPNNTPFACGVRIHNVSMQTTDSHWKIGYMQPQDGVNMFKKLEIEGLSVYWNCGQQITEEINNYMDLQFNLCPEKVVIELTKRQLLEMGSLGKEWARFDRSRQHRKWRPLVTVGENAKEWWNFAYNRVQDQERQRKTRCTWSFAYNRARQLNSYCRAYRRRLLSYLDTAAVSVNGQSNKFNERNETSRLGSVSGQNLDMKLTEEMGTATSPLNSSFTASLKKTANSEDLILMKQIERDTNYTYHELQLFRETVYRRILAEKEARRSSIENLLQSDDENFENINFQALCRLEILCNILPISAVLPHHLDTERTTSSNHSHSEETTKNFGGGLYSWLSSWLYGPQKEILEILKVEDEILDVLNESKDDSTVLHRDTLLSEIKLKLERMTIRFIDDFENQKDGSTRVLAMDLWQLTSCVHLSPRRHSTAMSLTVADLSLQRLCTYPADDISIENTQNDETNKQERESLMFGFAKEMTQILFAIGKAGKSNSSNTSDNAKKSDLNNALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WFY5</accession>
    <name>A0A3P7WFY5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004165">
        <property type="protein sequence ID" value="VDO41933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WFY5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="312" mass="35796" checksum="AAB94C2F9A43BEED" modified="2019-02-13" version="1">MQVLRVQHRLTQKYYAVKLVSSDCGTVNNELSILSRVQHPFVIRLEEVFKSSSRLFIVMEMASGGEMYNRVVAKGRYSEGEARQALRMLLNGLAYLHSIRVTHRDLKPENLLYSDTTPDARLLITDFGLAYQAQTPEEKMTETCGTPEYIAPEVLLRSAYTEKVDMWAVGVIAYILMSGIMPFDDDCRSRLYTQIITANYIYYPQFWSGSELAKDFVDALLETDPDVRLSATDAVKHEWFMGSRSQLKVIIKTRPSSDHSTIQRTRSSRSIRSVTRSDHGHRVDPREVDRLASDLQRLAKFQQHSTKHYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XPE6</accession>
    <name>A0A3P7XPE6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001018">
        <property type="protein sequence ID" value="VDO31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XPE6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF65">
        <property type="entry name" value="NOSE RESISTANT TO FLUOXETINE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21836" checksum="AEDEA19F0A57BC9F" modified="2019-02-13" version="1">MFLIFQWKIVTGWILSTIFGFLAVFGLYNYARTGDISEAERIIYALFGRNAYALSLAWVTFACATGYGGAVNDILGWRAWIPLSRITFCAYLIHPILLQIYYLSRPHAFHFTTVYQMARLAFEVPVSILENMLIDKIMGKIRAHRCRKPPRVKAQFGVVNDDDADDPILKEAVLQSYADDVASSKKQQELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ACI8</accession>
    <name>A0A3P8ACI8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01039859">
        <property type="protein sequence ID" value="VDP11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8ACI8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="262" mass="29963" checksum="28FEA9E8F036EB4F" modified="2019-02-13" version="1">MCYNVTIKYLLGPLADLELALVDYVSSIVEQKGFKPVVVPDIVHESIPDGCGLQQRSDKGILYRLNEYNNFCLSGTSEMGLSSLVSGRVFRYDELPFKLKALSRCFRPEIATNAVESKLYRVHEFNKVEMFVVCNENDSDLELDELVKIQTSIFSSLGLHCRLLDMPSEELGASAARKFDIEAWMPGRKMFGEISSASNCTDYQARRLIATTRTLIALLETYQNERKRLLELPYDIRRRMPKTRSWTINLHNAIDTNRRCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BFY7</accession>
    <name>A0A3P8BFY7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043248">
        <property type="protein sequence ID" value="VDP24912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BFY7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP24912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="97" mass="10884" checksum="63C8FF40B1BEAF46" modified="2019-02-13" version="1">MEQIAVCVNRTEPVLLVGETGVGKTAIVQLLADRIGTTLRVVNLSQHSDSSDLIGGYKPVSIPYLLKPLKKEFDELFAATFDTKRNEKFLRHLENVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYN9</accession>
    <name>A0A183GYN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Na_Ca_ex domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS349</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000108">
        <property type="protein sequence ID" value="VDO25490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYN9"/>
    <dbReference type="STRING" id="387005.A0A183GYN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000034801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000034801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000034801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000004">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="157"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="396"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO25490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000034801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64059" checksum="6B3712EF473B1A83" modified="2016-09-07" version="1">MRRMWNNSRLAVSSFHSSCVLLILFAVFWTVAYIYATDHLFSVKKRQLIDKYSLNLRIKVDDKMHYSELIDKKLLKSINKSENWHGTVTSLKSSHELLVSKNLPFVPMFKFRRLLTTTSTDRCIYSSAHISSSSSSFFPKDYFTLEQRRRGALFLHFFGLIYMFIAISIVSDEFFIPSLSVITRKLSISDNVAGATFMAAGSSAPEFFASLFGVFIAQNNIGIGTIVGSATFNILCVLAFCTFFSLEVLKITCWPMLRDIFFYVVALFLLVLFFLDEEIQWHEAISLFIIFIIYAIVMGHNEQLEKNFKRNLKKITQVLICCGSSCGLKFDFDCSFIQKCVILEERTSASEEVPINIAWPSSAKARLTYLFLAPIMFPLYYTLPDSKNSSSRKYFVITFVGSILWIAFFSYLMIWWAKVIGETLAIPNEIMGLTVLAAGTSTPDLISSVIVARKGLGDMAVSSSIGSNIFDICVGLPIPWLLQFAVLWLRSSSSTSSIATIPVISKGLICSVGLLFLVLIFLVIAVILCRWKLNKIFGMAMLIAYLAFCLLSVLLELGYIVCPLIIACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ00</accession>
    <name>A0A183GZ00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CULT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000151">
        <property type="protein sequence ID" value="VDO25871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ00"/>
    <dbReference type="STRING" id="387005.A0A183GZ00"/>
    <dbReference type="WBParaSite" id="OFLC_0000045901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000045901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000045901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000045901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20515" checksum="53590F7024C3EB12" modified="2016-09-07" version="1">MCRAGVSQIYVPTMVGVVLHVDCSCRYVPVALLCRNCGHEIVEGSTLTNEKSVKALRSYNMTILGRNQLVQVFENAVPEKFDVITASTAELKLAGKFEFLYLIKRILEEKEIIVLQSYRADTWWPNYEWTVCVCPSCGFHLGWYFQSGNIQVKLHKSFFGLVLDYLISEEYVDMLTWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZK0</accession>
    <name>A0A183GZK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000239">
        <property type="protein sequence ID" value="VDO26600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000065901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000065901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000065901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000065901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8128" checksum="49A0B6B12D2B7687" modified="2016-09-07" version="1">MGNLQVRIKIWPIFDWSLTMRRRALAMSIGKLKFLKTQKGVQEPEKAVNLKDEAFAVTHNHLITSSSLDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0B2</accession>
    <name>A0A183H0B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS922</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000376">
        <property type="protein sequence ID" value="VDO27581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0B2"/>
    <dbReference type="WBParaSite" id="OFLC_0000092101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000092101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000092101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000092101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8214" checksum="98DBEB50717D5845" modified="2016-09-07" version="1">MLGDNARRDRLFNGRKGQEKININRRMDGSVLRACHKSVGTQQMANRIEGSSRFTDRSACQLNATGWLAGNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0R4</accession>
    <name>A0A183H0R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein Asterix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1074</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000460">
        <property type="protein sequence ID" value="VDO28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0R4"/>
    <dbReference type="STRING" id="387005.A0A183H0R4"/>
    <dbReference type="WBParaSite" id="OFLC_0000107301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000107301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000107301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000107301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13908" checksum="1A11863873B50E44" modified="2016-09-07" version="1">MQNGDVKRPGRIVRIWNIFHSFFRYKPVDPQSSLSVADDPIPEYMNVLGMVFSMCGLMMRMKWCAWVALLCSCVSFANARTNDDTKQIVSSFMLSISAVVMSYLQNPQPIIPPWTNLLWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0S9</accession>
    <name>A0A183H0S9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1089</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000467">
        <property type="protein sequence ID" value="VDO28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0S9"/>
    <dbReference type="STRING" id="387005.A0A183H0S9"/>
    <dbReference type="WBParaSite" id="OFLC_0000108801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000108801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000108801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000108801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30217" checksum="3F28B7D0DE528BB2" modified="2016-09-07" version="1">MIRLDLNGKRMRPDQGWILGLLVGLSDFKCTEIRLKELNCTRGLLGYDRCIKFAINAWLNDINNKQLVQFITSYGPIKSLVEIGFGIRDLFLMPVNEYCREEGHIVKGLQRGAESFGISTATAAVDMLQRMVGVVQKCGLHLRFNEILQSVAELAFDIVSPEYPIYRHRRNMIDYTILRPPNDIREGFNMALEAIGREISDTALDFQLAALEDQASGYSTVRGFLRQAPTTVLRPIIAVSKATVNILGGMRNQMKPGSHREEIEKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0W9</accession>
    <name>A0A183H0W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synapsin, ATP binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1129</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synapsin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000490">
        <property type="protein sequence ID" value="VDO28365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0W9"/>
    <dbReference type="STRING" id="387005.A0A183H0W9"/>
    <dbReference type="WBParaSite" id="OFLC_0000112801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000112801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000112801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001359">
        <property type="entry name" value="Synapsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020898">
        <property type="entry name" value="Synapsin_ATP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020897">
        <property type="entry name" value="Synapsin_pre-ATP-grasp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF17">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02078">
        <property type="entry name" value="Synapsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02750">
        <property type="entry name" value="Synapsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01368">
        <property type="entry name" value="SYNAPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="230"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO28365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000112801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58481" checksum="C142E103B6B8D9C0" modified="2016-09-07" version="1">MESISSGVNFLRRRFSSQDNEEDEKSTPASAPGGRGPQQQQAQYQQQQQSSHMQNGPPNSFSLASLANKVSSAISAPTSPSKQSMSMYSQVQGITKNLMQAASNAAASYIQGPHKCILIIDDQQIDWSKYFRSNRTGWQLRIEQAPFSEIHVCCHSNRKCTVDILESGKEHRRMQPDFVLFRQNANSEKGDYTNIVIALLKGGVQTLNSPESIRILLDKNWTFNRLQWICETTGPNAIPLIEQTYYPLFDHFVSQSAQSRFPIVIRVGHGSHGLGKMKIEDENHMLEVENMLRSIKPVEVVIEPFIETKYDIHLQKIGTETRAYIRKGISNDWKSNASSAMLEKIALSNRQKQWLSIISDAFGGLEVFGIDILVAKDGREIVHDVNDAITLLGDTQEDDRRAIADLIQAHIIQSAQRVTQQIAATRIGIPPVPPPRPQSANVSRSSTSETNISDFEGETAVNNDDKLGRKNSIGQKASQLQRSVRQPSKQGKEPSGSNLQQQQHQDDTMGQLKRTFAGIFGEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H111</accession>
    <name>A0A183H111_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000513">
        <property type="protein sequence ID" value="VDO28508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H111"/>
    <dbReference type="STRING" id="387005.A0A183H111"/>
    <dbReference type="WBParaSite" id="OFLC_0000117001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000117001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000117001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000117001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24609" checksum="C2ABF08D52F0C40E" modified="2016-09-07" version="1">MDAFLGTVYINVVILDAARYTVNITRAAFEFTIQRVGCHLLHCVSVSFIATTMEVDKKQLCSPFPQRIVSCCGDVYRIIRLEQRSVNWIIPDPGARSWNCFHPMFNRLATILSLLVLLPSKHWSPAPFLPMFIFSMIDFLLYFSIVPDTRGNKLLDPGEVLEKELTTHKSTVVAALIRHHFRTFITSSKICLTKQNTINKFVVVEFCNILERNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1B5</accession>
    <name>A0A183H1B5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">OFLC_LOCUS1275</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01000575">
        <property type="protein sequence ID" value="VDO28934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1B5"/>
    <dbReference type="STRING" id="387005.A0A183H1B5"/>
    <dbReference type="WBParaSite" id="OFLC_0000127401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000127401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000127401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="19">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="739"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDO28934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000127401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="938" mass="108343" checksum="D6FB627168A63E0E" modified="2016-09-07" version="1">MKILNKWEMLKRAETACFREERDVLVHGDRRWITNLHYAFQDERNLYLIMDYYVGGDLLTLLSKFEVRIPEDMARFYVAEMVLAIDSVHRLGYVHRDIKPDNVLLDINGHIRLADFGSCLKLLPDGTVHSNVAVGTPDYISPEILRAMEDGRGRYGAECDWWSLGICMYEMLYGVAPFYAESLVETYGKIMSHQEMLDYPDDIDISEEAKDLMKRLICPRETRLGQNGFVDFASHPFFEGIDWEAIREMDTPYRPEDTKPPNVTAPFTGHHLPFIGFTYTHDSMMSDCKSLSLSGLDSSVDSLPALTAEAYERRIQRLEQERMELSRKFQEANRLIQTRFHGSAPDGETMNDSTKYEQTIAQLKDEVQILKKRLAEENSSSMRPAKDSSQEELEKKVKELKEKNRQLILDKQDLQRDLEETSERLTIQTRELKEAVKHRDLAKQDYDELNTALIDERDKVKRSEKLVKERESELFQLQQKLDVFKLELRKLENVRKEVEATAERAHQDLSSERLLRETLQTKLASQESKTESEEVARLTSELQKLNVRYAEMVDSEEKKCQQTVEYWKSQMIDLQNSLDQQQMDLVKLKERHDEERTEWRTKHEEQIVSIENLYERRLKLLEGENSRLGRENDELRNEMNKLQSEIKSRLSTPLPFPNASGLTESQLQELLQWVNDEKDARDSLQNLATRLHGDVESLKIQQSSSTNNPYSNGIPVATGGAERGGWGSRRVNKQTKIELLEAQQALQSEIRAKQQLLEELKKIRSAYLATKQRLDQSDKQIAEQNREIERLNEEKEQLSRILAQHSDYPDQSSSFFSVVSDVNNDRLSSVQNASILFRDSFDIPSSPANGSDYEVSNSSLRRHQQLKQQSFNSSISPALPPTYENTRVLTPTPSTASTLVMGTQGRGASPKVGYCNRFSLFQTLINHFKCLSPINNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1F9</accession>
    <name>A0A183H1F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1319</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000599">
        <property type="protein sequence ID" value="VDO29097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1F9"/>
    <dbReference type="STRING" id="387005.A0A183H1F9"/>
    <dbReference type="WBParaSite" id="OFLC_0000131801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000131801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000131801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO29097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000131801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18062" checksum="9E124D55B4008B95" modified="2016-09-07" version="1">MFLLPTYIHSIPSGTSTDSCPGSITDSFLAHYPWQATSSEQSSSSPENKTLAAMGLTKCLLRKHKNNRKPRTPFSTQQLLSLERKFQQKQYLSIAERAEFSASLQLTETQVKIWFQRKRSDYLSQLDMLLYLYSTQCYILAVFILKRSESDFKIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1X2</accession>
    <name>A0A183H1X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1482</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000706">
        <property type="protein sequence ID" value="VDO29712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1X2"/>
    <dbReference type="WBParaSite" id="OFLC_0000148101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000148101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000148101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000148101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21588" checksum="C65153127A28DEBE" modified="2016-09-07" version="1">MERTVEVYEVIAKLNIGTCKIATFTGNSKWMASKNTKNWIHELRNWQAPHYKTLECKQICFHIHGETSSCEYKLHFISDRSTVQADCLLSHLLLGTEYNGLPLILVRDLEEILLRECLALVGKSRKVVLLLMKALLISGLGMVISKGSYSTNQREHMIVRTMELVTKRSFSSLHGEKFLLHTSLSYSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H243</accession>
    <name>A0A183H243_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 15 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1554</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000752">
        <property type="protein sequence ID" value="VDO29957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H243"/>
    <dbReference type="STRING" id="387005.A0A183H243"/>
    <dbReference type="WBParaSite" id="OFLC_0000155201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000155201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000155201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000612">
        <property type="entry name" value="Peptide transporter 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO29957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000155201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="769" mass="85842" checksum="4B57DD07C11A390A" modified="2016-09-07" version="1">MMEFEKLPESNQQNPLLTPSNKSRRTDYYNMAMSNRKGLLASLRTYPPGVFFMLGNEFCERFSFYGMRAVLMLYLITEHHFSESRASLFYHSFVACAYIAPLFGSIAADNYFGRFRVILWMSAVYVIGHVLLSIGAIPQLDQSFRSIFDFGGLAVIALATGGIKPCVSAFAADQFEEKQENERNQFFSFFYFSINAGSLLAILLTPILRGRVKCFGSEYCFPLAFGVPGVLMLLAFILFLAGWRYYKIIPPGKGNVVFSVICCICYAAREKLNSLVRGQGKAKHWLDHASPKYNDHFLRSVKSLVSVSILFGPVILFWALFDQQGSTWVLQARRMDGRVGPFMILPDQMNTFNPLIVLITVPIFEAWIYPMVQKFCKVTPLRKMAAGGCLAAIAFVMAGLLQLEVNKTMEACPAHDRVILQLFGDSSHSYEINGTKLIDGKIDLPKGVYTVTSNSIENVQSFQLNLSSAASGYVVGLFKSSRNKSSFSFFPYNCEKTENGGTRLYLLVPDDSILANGSFYIVDSHQNIHQKAVIKSGIFLLSMEAFVCLSLVSNQSNFVVNNINHDYLNIVIVHLNSLSSSGQHVDIEPALISSPEYVLKIGPGNCSVSDCPYNYSIYAEAGGAHVVYITEDVINLYAVVRPNTVNILWQLPQFFVITVGEVLFSVTGLEFSYSQASPNMKSVLQAIWLMTVFLGNVIDMLISGSHIVAEPATEFFLYAFMMVIVIGLFIVLAIRYDYSNYTRDEDAQLKYIEKQSSHGNAVENGKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2R9</accession>
    <name>A0A183H2R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1779</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000903">
        <property type="protein sequence ID" value="VDO30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2R9"/>
    <dbReference type="STRING" id="387005.A0A183H2R9"/>
    <dbReference type="WBParaSite" id="OFLC_0000177801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000177801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000177801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000177801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13263" checksum="90ABEE64FD0F46D2" modified="2016-09-07" version="1">MSDYPHPSYNRTANTNTTLSSHKHNIPSSNQIPQQQNTHVPYVPSMNSIPSDVYGSSNSQIPYQQPPINPHHNGVFQLNPNAPPFHPVYSYHVHEVPSYVNAPMYDGYRPANAYDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3X0</accession>
    <name>A0A183H3X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-loop-helix DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2180</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001198">
        <property type="protein sequence ID" value="VDO32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3X0"/>
    <dbReference type="STRING" id="387005.A0A183H3X0"/>
    <dbReference type="WBParaSite" id="OFLC_0000217901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000217901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000217901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000217901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18408" checksum="04F9265C2F82DFAE" modified="2016-09-07" version="1">MHIATTLQFDKGQRKILKRAWERPPFMVAKRNARERTRVHAVNQLGQIRLPNVLLQAFVALKFHLPAIRSNAKRVSKLKILRAAITYIAALTDLLRGNADFPKLKFPETSNQCCDKIMNIPFRSKRENQVSNKNDVMKREESQQRQQRTEHQNIHDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H419</accession>
    <name>A0A183H419_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2229</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001238">
        <property type="protein sequence ID" value="VDO32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H419"/>
    <dbReference type="WBParaSite" id="OFLC_0000222801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000222801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000222801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000222801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11061" checksum="5AC4ECB31ECF2735" modified="2016-09-07" version="1">MYRSHNKRTQISDQIVGEKPLSSNWKRQEIFMRESMQMKNKVLLNFSNAAENIEFTIPHFAATEKTEETDNGIYDLSSSDRTDPIEEEPHEKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H538</accession>
    <name>A0A183H538_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS2598</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001523">
        <property type="protein sequence ID" value="VDO33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H538"/>
    <dbReference type="STRING" id="387005.A0A183H538"/>
    <dbReference type="WBParaSite" id="OFLC_0000259701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000259701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000259701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20794">
        <property type="entry name" value="C1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000634">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000071">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000012">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PB1" evidence="15">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="250"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000259701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50807" checksum="9D1A21886A3B98B2" modified="2016-09-07" version="1">MYVTNEDSISSSEDVKLKTRFQGQVLVLYAKIPLRMETFLNSLREACKQAYNQPITVKWIDEEGDPCTISSQRELDEAIRLLHSNGEAELNVHVFLGIPPLPGLPCYGEDKTVYRRGARRWKKFYHVNGHRFQAKRLNRRVQCFFCNDYIWGLGRQGYRCADCRLCVHKKCHRAIRQPCGDNNNGMMVVPSPSAPVISPKFNGAAVERIGLDNHAFKESEIEAVQQGLVERRSGDIAAKDSKWTVSLNDFNLLTVIGRGSYAKVIQAEHKKTGAVYAIKIIKKQMFSDDEMHCMDIDWVQTEKSVFETASNHPFLVGLHSCFQTDSRLFFVIEFVPGGDLMFHMQRQRKLPEDHARFYSAEIIIALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIGPGDTTSTFCGTPNYIAPEILRGEDYGKFTKIFQEIYQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6D1</accession>
    <name>A0A183H6D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3042</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001913">
        <property type="protein sequence ID" value="VDO35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6D1"/>
    <dbReference type="STRING" id="387005.A0A183H6D1"/>
    <dbReference type="WBParaSite" id="OFLC_0000304101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000304101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000304101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000304101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19370" checksum="6E91E123D2E18422" modified="2016-09-07" version="1">MQHLMLRVDDEKSDSRQQKILAKKTNKPLMERKRRARINKCLFEMKQMLVDDIKYRSPSHYKWEKADILEMSVAYIKQLRCIAAYNKAEQAFSSPDFVDGFSDCMSEMQNYTLLENWTADLREYNNRLRSHLNGRLQLLSKSVMKLDMKCAFLQTNESTELMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6D6</accession>
    <name>A0A183H6D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3047</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001917">
        <property type="protein sequence ID" value="VDO35078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6D6"/>
    <dbReference type="STRING" id="387005.A0A183H6D6"/>
    <dbReference type="WBParaSite" id="OFLC_0000304601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000304601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000304601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="3">
        <location>
            <begin position="218"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000304601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="57640" checksum="B8D5287B858571CA" modified="2016-09-07" version="1">MRWWNDLWLNEGFATMMGQKAADFVENTTLRMSQYFAADITLKALSSDQHTSVTQPISLKENSGRIHGQDIKIIYNKGAAVIRMIESTIGEEVFRKGLNLYLIDFAYTNAGKNDFLTSFSKIFKAIDHHRDPFLGTNFSVYDYIDSWIYQKGFPLLKVRKVGNYFEITQKILDFDNKSEFANTQWKVPIFTRENQHNELNWLEEGKKIILLHGSRTFVLDPDFHGYYRVEYELNYWKLLIDHLLYKHNYFSVSTRLKLLDDAFVLAETGRIPYTIPMKMSLYLRNETKVVPFITFLSRFETILYRVHRHPNASLFNKYIQFLMEPSYDRIIKAETNSDASYNMEFEFIRELIYLKMCAGGYERCIQIFRSRLTGLYKNCSRKILSNPCNRIEPSLRNIAYMVASKYGNQTELEFMISKFHAEEYHVERDRVFSALTSSSNHSYIEVLVKEVLTKKEKDTDFRPKLYELSRLLDLLSTRMFSFRKLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6E4</accession>
    <name>A0A183H6E4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3056</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001923">
        <property type="protein sequence ID" value="VDO35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6E4"/>
    <dbReference type="STRING" id="387005.A0A183H6E4"/>
    <dbReference type="WBParaSite" id="OFLC_0000305401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000305401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000305401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000305401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22588" checksum="A89344E1EF73785F" modified="2016-09-07" version="1">MKIDARVKAAVERGQIGWGIVLLLLIELKVDYEGGTMRSVKHGRKKGRRRINYSKNLTAAKKKAIKKRKTMDGITCKQMRIAWDKNATIKQNMKAMGLAYDSNKLFSLHPSISKHTEEMEIDDPKQYGSLKSQIQKAKSTSGKPEVKKVIAALEKEVEDEEIRQKKGRTYRLLAKDIEFCIYMIEKHGDNYEAGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6N9</accession>
    <name>A0A183H6N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002019">
        <property type="protein sequence ID" value="VDO35469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6N9"/>
    <dbReference type="STRING" id="387005.A0A183H6N9"/>
    <dbReference type="WBParaSite" id="OFLC_0000315001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000315001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000315001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000315001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8193" checksum="CCEC35F31A5F326A" modified="2016-09-07" version="1">MGKKQHQKDKLYLTTTEWKETYGGHKDDTGRRMQRAFFKRLPITHCSLSLLPFEDPVCSQDGIIFDLTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H762</accession>
    <name>A0A183H762_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3324</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002191">
        <property type="protein sequence ID" value="VDO36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H762"/>
    <dbReference type="STRING" id="387005.A0A183H762"/>
    <dbReference type="WBParaSite" id="OFLC_0000332301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000332301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000332301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF73">
        <property type="entry name" value="LD06050P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000332301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62270" checksum="9C8C534A602A0D59" modified="2016-09-07" version="1">MSVKKSGLLHDLLKLDIDFQTYICSSMLDPYLLHRAVDRVVVEPIIKDNLSRSGKLILKCKNFMICIFEIEDLDDCVAVAQGIQHDYPFYYRCPFTVLDNGWTAFDAEQEYAKLMIRCKDGWRISAVNKGFQVCNTYPEMVIVPKGIGDDYLRISATFRDGGRFPILSFYHEETKSCLIRCGQPLVGPTNRRCKEDETILNSLLSSTSKGVIVDTRTKALAQSAKNKGGGYESQMFYSQWKYIYGGTPRIKEVHDALAKLVECEFDISSDFVIVCTETTINVDRWISRLGSCGWLQFISDMLTCAATVAQCVHCEGSAEVPVVVHGAEGTDSTLLVTSLAQLLLDSDSRTIRGFESLIEREWISAGHPFSYRCAHSAFATGAVTGPYESPMFLCFLDCVWQVYQQFPCSFEFTEEFLIFLFEHAYASEFGSFLGNSEKEKARFEVKTRTVSLWSYVNNPEILRTYVNALYEPNSAVLWPCVAPQSIAFWERLFLRWIRDWKQMDGIKQTIMQWKVREKELQSKVLILRRQMMELSKDIQFTSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAV0</accession>
    <name>A0A183HAV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4612</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003580">
        <property type="protein sequence ID" value="VDO40493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAV0"/>
    <dbReference type="STRING" id="387005.A0A183HAV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000461101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000461101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000461101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF60">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000461101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39660" checksum="B82BFB351C544148" modified="2016-09-07" version="1">MRLALWEARHAAGLKNYDDAARSYLALFSELDPKDRRKYLDEFVAVLEEMGSINGGGDYSKQIMLLLQSRVLFPHEAAVLNASAKFFFVVEQLQMEYICICMTSQAYKIYLQSRIVFDLGRLLEAFDFAQEAVSGSEGLSHIYALVNLENIKSNIMDQWHWAMLNDVKRNSAYANAIELVAKWRPESRVLDIGTGTGLLTSIARRYFKHNVYCCEVDLNMCDIAEKILNEAVIRKHSSEVTIEDVGSENIDVVITETMDCGLLGEGIACSLYDVQTRILSSSPATVYACIIESPAIMDEHVTVFCGRRFVSDSVTASYNTYGTLGELEPYWCCSADEIRGGYKVLSKIIEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB85</accession>
    <name>A0A183HB85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3800 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003764">
        <property type="protein sequence ID" value="VDO40935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB85"/>
    <dbReference type="STRING" id="387005.A0A183HB85"/>
    <dbReference type="WBParaSite" id="OFLC_0000474601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000474601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000474601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000474601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12455" checksum="F8B23380CC94F0D5" modified="2016-09-07" version="1">MIITTEGTNEERLASNRANNLLKSLLRARHPNLMNDDAELAVDIWLSATPLERISMVDGCPSTSTMDNIENLTKQNRNILIYCLCSKYLIDFDSSHNTPLDLSLFTIPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBT8</accession>
    <name>A0A183HBT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004025">
        <property type="protein sequence ID" value="VDO41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBT8"/>
    <dbReference type="STRING" id="387005.A0A183HBT8"/>
    <dbReference type="WBParaSite" id="OFLC_0000494901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000494901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000494901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="141"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000494901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37171" checksum="7B1168C499CC4086" modified="2016-09-07" version="1">MDNHRCTTLIRYISMIGQIVRNYFSATGGMVTFFAPYNEAFERIPEYIERRLLRDRIWLEKILKLHIVPNKELTINEITNETIVNTVDNIHQLYFIQSEWPRNNITYYVIGGGVRAAILMDNVAAVNGIVHFIDRVLGVPYQTLYEVMRNDSRLQTSYSMLQNLQLRYSLDPWQVLTPQQNFTFFVPVNEAWNKVSTSQKYKMTDGRHWLALQYVFKRHIIQGLALMYTDLRERTYVMMNDEKVVIRRRGRSFELYWPRGNRVARIIPGGEKAGINGFMHMIDNVLIYERDLEALASSTLNLAHFLLISLLIYVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC02</accession>
    <name>A0A183HC02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5014</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004104">
        <property type="protein sequence ID" value="VDO41781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC02"/>
    <dbReference type="WBParaSite" id="OFLC_0000501301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000501301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000501301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000501301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14027" checksum="ACA09850979F0F6A" modified="2016-09-07" version="1">MYIIALQQRRSYTDKKACGWRIVNDRNNDSSAGEDGFSDYHPVSLPGTLVSLGVKSMVSLDAARQSTKIIMNDVRLHCREYSVDGWMDELRNSDLYISFKIFKILHIYRKLLNRRRQPSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCM0</accession>
    <name>A0A183HCM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5232</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004387">
        <property type="protein sequence ID" value="VDO42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCM0"/>
    <dbReference type="STRING" id="387005.A0A183HCM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000523101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000523101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000523101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000523101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44342" checksum="E9C52B42EB368CAA" modified="2016-09-07" version="1">MINSVHVQCGECPTVSFYNFQQIRQHHSDAHLEILYRCAICHQIFNSQYRFQKHSAVHVKEVLRYYCSACSIPFETRDLLAIHVQLFHDRPAVTLMINNLQRNSSENGFCKQQLQSENRLMKCLVCDMKFENEDELDFHRLIAHCKVPRSNRCADCQTQIQTVTHFKEHIREHMQDEGTVSCIICRQALRNDAQIDAHAQYHLQFSDDALESNRECSICQQHFSRESLGLHMVEHSNNGDCPYCDGHFPNIESLLAHIDSTHSSVEAAYQCHNCRQTFHFKSQLQNHDCSTVAHGTLLNSFRERISPILNQQQIYQCKYCPKMFGSESALQGHSQVHSTRAFRCDLCVLSFSSNQRLETHRKKHFAEKNFTCQICDLQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCT9</accession>
    <name>A0A183HCT9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS5302</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01004487">
        <property type="protein sequence ID" value="VDO42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCT9"/>
    <dbReference type="STRING" id="387005.A0A183HCT9"/>
    <dbReference type="WBParaSite" id="OFLC_0000530001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000530001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000530001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="11">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000530001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17820" checksum="AE3D5CDC83B604B2" modified="2016-09-07" version="1">MEVLKDIPGIIERRVDYNSSITFLQQLEITHNSDLFIGIHGSGLTHLLFLPDWAVVFELYNCGDVNCYLDLARLRGVKYVTWTKSDKVFPVGEDKHPQTGEVHQKFRNYRFDRDEFRRLILMQVEYVRRHPAYVMELRKQKRKQYNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD32</accession>
    <name>A0A183HD32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5394</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004610">
        <property type="protein sequence ID" value="VDO42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD32"/>
    <dbReference type="WBParaSite" id="OFLC_0000539301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000539301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000539301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000539301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15705" checksum="1EE2BACF176958AF" modified="2016-09-07" version="1">MNDLRHLKKINEDFNDFNKEQEIIEARINRVYYRCIYPDLNIDELRLKLNKPDMKIGKEEVCSLFERTMGHANEIYEKVSTLLHLCRLAIRKSFPTSQLANGQFVENLPIPSYLKDYLDCYRCDIFETFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDP1</accession>
    <name>A0A183HDP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5603</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004900">
        <property type="protein sequence ID" value="VDO43702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDP1"/>
    <dbReference type="STRING" id="387005.A0A183HDP1"/>
    <dbReference type="WBParaSite" id="OFLC_0000560201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000560201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000560201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000118">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="6">
        <location>
            <begin position="209"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000560201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37955" checksum="64DCECC0261833E8" modified="2016-09-07" version="1">MNLEDSSQFAFYEKDITFVGVVGMLDPPRAEVISSIKECRMAGIRVIMITGDNKNTAEAIGRRIGLFAEDEDSTGKAFTGREFDDLPPEQQSDACRRAKLFARVEPAHKSKIVEFLQSHGEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKSASEMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLVAALGIPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSAGESLISKWLFFRYMAVGSYVGIATVGAAMWWFLLYEDGPQISYYQLTHWMRCEIEPENFVDLDCAVFEDAHPNAMALSVLVTIEMFNALNRYFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDV4</accession>
    <name>A0A183HDV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aconitase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004988">
        <property type="protein sequence ID" value="VDO43894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDV4"/>
    <dbReference type="STRING" id="387005.A0A183HDV4"/>
    <dbReference type="WBParaSite" id="OFLC_0000566501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000566501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000566501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000566501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21552" checksum="7FF7D2B24E10AE07" modified="2016-09-07" version="1">VKGKCTTDHISAAGPWLKFRGHLDNISNNLFLTAVNAENGEMNKVRNHLTSKYDTVPQTARHYKSKGVAWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFADPNDYNKIEPTDRISIVGLKDFAPEKPLKCILKHANGKEEQIWLSHSFNAAQIEWFKAGSALNHMKALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEB3</accession>
    <name>A0A183HEB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005222">
        <property type="protein sequence ID" value="VDO44471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEB3"/>
    <dbReference type="STRING" id="387005.A0A183HEB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000582401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000582401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000582401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000582401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53982" checksum="B192D57F0B2F7947" modified="2016-09-07" version="1">MAVYATVNDVRISDEIKSDVAIEMNEPWYRAVFFDSVTCDFHSKLKYTKECQARSCSLFAAHKAAFNFFALCKKHVFPDYEFSEQHVPNKASLSTVRENFSECASQQSSIYAAGYTSVENIPERSSISLLSPKKKTLKSNVRKETSSICEVGSVEQNAVALERKTRSTCNTFLDDKVDELGNMTNHIGFCYDVEKWLQTQQPMQLTDNWEMRVCSRNPHISAASSVDKHYAPVDVVIDQQLISLPQFKSVPSYRSSQKIPSYPSEKPRSNFSGIHAIESQLPLNYQCSTSDKGFSNVVINGNVSRKDEVLVDRSLIENDSDTEIFCNISIPTSSFCKHDSLISASKMRQISALLSEEIGTTHDVEKTVQNTCHSQPVATPNAYPVSSKSSKVLLSKANQNKFLPSKGESMECSLDLSFNSQKVLKSPLSNDNLIPERTSGGFCIPNICQTNYFWMEKNPSAISTSFRKTGSQQKNIHEQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEH5</accession>
    <name>A0A183HEH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF6700 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5885</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005307">
        <property type="protein sequence ID" value="VDO44674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEH5"/>
    <dbReference type="STRING" id="387005.A0A183HEH5"/>
    <dbReference type="WBParaSite" id="OFLC_0000588601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000588601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000588601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000588601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38911" checksum="3D893EFEB290EBF5" modified="2016-09-07" version="1">MDLFGSAAEEKTVSGITKDVPEAKIQRAYETYRLLGRYISSHCLGSVLVVLKKVVESTPDAKSMRKVSRLLWQYSLGISINEGIEPAVLLIFVYQLLKERIAEVQKETNSSVQLDVLQTKSEKRPESCLVLEKEPNRIGMIVKVSTRSKMHIFVEFGLSELYLVLKKKVFDVESKDDVARLDPFVDIILQCLKLKYDKIVVNSLRCFLILLKFPLPSLRSVMTQFLNHLFILLADYTTSDATGNIQEYVRKSVEVSQLVFKAVTQIIKDAPSLVLTSKRLQLLLTYVETDIVDNQKQAVAFPLIKAIIIRKLQDSKVIEIIQYLAETAVTSEISHIREQCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEY8</accession>
    <name>A0A183HEY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005538">
        <property type="protein sequence ID" value="VDO45235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000604901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000604901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000604901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000604901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27418" checksum="F97361AEF7B8905F" modified="2016-09-07" version="1">MTQSSTLLEPSNDEVYEFDVDLLYSWEQSSGTISYEAWSSNLEEAFHIDKDGKMLPDYNDNICRAKINQRLLRHSMPAYKTLTARSLAMLNEAKRRERIQGHLFQRIVIPCKQDASMERYEFISKICDDAISEYMAATNLDNKLLKINLECGGNLPPRIKINGIRAERSVKYENDRKNYPDISQEEQQVYKMNHSFQHLSTCSPALPYPSANTFSRCSIENYVKLLKGRRKTQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF89</accession>
    <name>A0A183HF89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Presenilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6151</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005700">
        <property type="protein sequence ID" value="VDO45592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF89"/>
    <dbReference type="STRING" id="387005.A0A183HF89"/>
    <dbReference type="WBParaSite" id="OFLC_0000615001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000615001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000615001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF25">
        <property type="entry name" value="PRESENILIN SPE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO45592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000615001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36509" checksum="736EA7F4281AB935" modified="2016-09-07" version="1">NKNFRDLFKAFGFQTAPPILTTLIVITYGTVGILVFFTKITPLYMHQFYVICNCSLVSVFYLRMFPTHTTWFVLVCIIIWDAFAVLAPVGPLRRINEKAHEYSDQVLRFLMFTAEDRYDAPQDETVVDIYAAEPKQNKLSENHETNSIMKLDLYTFQKSYVSSRKSLFQYDFDASFFFKSQETEDEYIRRRKTLHSKNDTQAEIGRICVKFEACNEKKYDEIKLTVYDALNDGSSVRLGMGDFVFYSLLVGKAAATHSAMCVVGSVIGILVGLVITLTILSGEDETAPALPVSITIALVLHFGIYLFVEPFYRQIIITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFN4</accession>
    <name>A0A183HFN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6294</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005895">
        <property type="protein sequence ID" value="VDO46054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFN4"/>
    <dbReference type="STRING" id="387005.A0A183HFN4"/>
    <dbReference type="WBParaSite" id="OFLC_0000629501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000629501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000629501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF91">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000629501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17782" checksum="60907B159FA11AA8" modified="2016-09-07" version="1">MKSFRFRIGLSALNSPSDLVLESHALRAIAAKYPDMEIYTYEYCRMIADQLNIILPNTLLNDGIAVIVLVIIALLFIPNPICTFWIFIAIITMDIGVIGFLALWDVKLDPISMITMIMAIGFSIEYCAHITYGFVSNPNDVTPTERCVEAMEKLACPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFT4</accession>
    <name>A0A183HFT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005984">
        <property type="protein sequence ID" value="VDO46270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFT4"/>
    <dbReference type="WBParaSite" id="OFLC_0000634501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000634501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000634501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000634501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16517" checksum="3CC63E992B852112" modified="2016-09-07" version="1">KESLEVETVVTRRLRPRRLLPIVPKSYKLHHQLREYHNNHRHHHHHHCRKEGRRTRVATQHKTQTLLKWEKQDIPNGTLSATKRISGISNSSNSFSPPSPVHFDKFFNPLTFSCNIYAQKWNFDKFSKKVYLSLKTKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGJ8</accession>
    <name>A0A183HGJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6610</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006390">
        <property type="protein sequence ID" value="VDO47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000660901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000660901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000660901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000660901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13480" checksum="57BBD1DCCE5ED96A" modified="2016-09-07" version="1">MLWLPQTSHGYGMIEKRYYLRVEYMELGYRLSPFKWFMYIQLFILKNSQKYGTFKTDKLAGHPKYINYIILASAEAKFAKKRAAMCVCLLWAVRMFKFLKMKNKREEDGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHH9</accession>
    <name>A0A183HHH9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS6943</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="EMBL" id="UZAJ01006928">
        <property type="protein sequence ID" value="VDO48590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHH9"/>
    <dbReference type="STRING" id="387005.A0A183HHH9"/>
    <dbReference type="WBParaSite" id="OFLC_0000694001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000694001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000694001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO48590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000694001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14246" checksum="2F9376D6C6DC8F97" modified="2016-09-07" version="1">MDHGEQARREGRFVFECSWEVANKVGGIYTVLRTKASVTTEELGDQYCMLGPYNEERVKLEVEILQPDSSPLKYALDQLRDLGFKASYGRWLIDGYPKVVLFDIVSAAWKLDQWKQEVLFHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHP4</accession>
    <name>A0A183HHP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7009</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007043">
        <property type="protein sequence ID" value="VDO48864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHP4"/>
    <dbReference type="STRING" id="387005.A0A183HHP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000700501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000700501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000700501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000700501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32600" checksum="BD9F6002CDDE97B3" modified="2016-09-07" version="1">MEQQQREDEHQESLVDVGASVSISRRLLDANYRCTHFLLLDSFSSLVERFIRLRPLRTSEDEKAVESWHTLIVTANDRATQISCFRNDDDVNTVSVWHRYVQRAVQKKETVKLLLHGISRQQSSSRLRDSTASTNSGHHFVAQQVTPGDACAVCHQNVPGVVVRTGLILHLSSGLVLTVVCSALVSSTCPNMEEKRLVVTAKCDIPPVSKRSATYTADTRTLTMSASCPHAGATYSGFLMKKGATFKMWKPRWFVLDSNRHQLRYYENETDMNCRGVIDLADVKSVEIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHX3</accession>
    <name>A0A183HHX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOR2-PAG1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7082</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007146">
        <property type="protein sequence ID" value="VDO49229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHX3"/>
    <dbReference type="STRING" id="387005.A0A183HHX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000708401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000708401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000708401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000708401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10666" checksum="BABDFE4311F58814" modified="2016-09-07" version="1">MLFNTTRRKDLFSKEHQRELAFMITFFMSKFCSQKVDMPIRLSLGNTILELVKPWDESVKTITSFLPGICCRMTKLACADLNTEIVNMALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJZ7</accession>
    <name>A0A183HJZ7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS7807</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008388">
        <property type="protein sequence ID" value="VDO52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJZ7"/>
    <dbReference type="STRING" id="387005.A0A183HJZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000780801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000780801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000780801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000039">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000016">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="158"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000780801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39249" checksum="78B3EFE7B9FC05D5" modified="2016-09-07" version="1">MVTGREDAANNYARGHHSIGRDMIDTVLNRVHRLADNCDGLQGFLIFHSFGGGTGSGFTSLLMEHLTIDYGKRSKLEFSIYPSPQVSSAVVEPYNSILTTHATLEHSDCSFIMDNQAIYEICHRNLDIDRPSYSNLNRLIAQVIVSSITASLRFDGMLNVDLMEFQTNLVPYPRIHFPLVTYAPIISVEKAYHESFSATNITNACFDPSNQMVKCDPTKGKYMSVCLLYRGDVTPTDVNEAITSVRQRRQIQFVDWCPTGFKIGINSKPPTVVPDGDVAPVPRALCMLANTTAIAEAWARLDYKFDLMFAKRAFVHWYVGEGMEEGEFTEAREDMAALEKDYEEVFYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK88</accession>
    <name>A0A183HK88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7902</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008557">
        <property type="protein sequence ID" value="VDO53072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK88"/>
    <dbReference type="STRING" id="387005.A0A183HK88"/>
    <dbReference type="WBParaSite" id="OFLC_0000789901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000789901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000789901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF32">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO53072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000789901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19954" checksum="4B286F120925EB11" modified="2016-09-07" version="1">MGMLVKKCFVTDGEGTDHPVLDSDGCSLDNFLLGELVYDSTLMKAYAQSQVFKYADSNRLFFTCQIQLCQKIMNSCSGITPPKCSKEIEVNERRNRRSALHLSSSGKIDQQLVEMDVSSSEMLIGGIDDMLIDTSSSSCFSPFLIALSNFILFILITALLAIVVAMKKKHGKQSFVLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKJ8</accession>
    <name>A0A183HKJ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS8011</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01008751">
        <property type="protein sequence ID" value="VDO53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKJ8"/>
    <dbReference type="STRING" id="387005.A0A183HKJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000800901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000800901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000800901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000014">
        <property type="entry name" value="adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000800901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18750" checksum="81FF1CEDEAD18F97" modified="2016-09-07" version="1">MSSNKSASELVNLLNDLFGRFDNLCGQCNLEKINTLGDCYYCVAGCPEPRLDHARCCVEMGLGMITAIKQFDEDRGQDVNMRVGIHTGKVLCGMVGMKRFKFDVFSNDVTLANEMESTGIAGRVHISEVTAKFLNNEYILEDGRDYAGIFHFHQAFLNYLNLFKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMV7</accession>
    <name>A0A183HMV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS8817</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010281">
        <property type="protein sequence ID" value="VDO57541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMV7"/>
    <dbReference type="STRING" id="387005.A0A183HMV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000881801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000881801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000881801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO57541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000881801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15921" checksum="3E1E6E2ED1FC0950" modified="2016-09-07" version="1">MHLIFCFFFSERSVLAKQRVIKMLIVIVIIFFCCWTPNYMWWLLLTAQDSFKTFDIWNSQVNTVITVLCYISSCANPITYCFLNKKFRTALLITFGCLRKDTNQYQTTYLPEQVDTLTPGKSTDEMSVLRIERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMX5</accession>
    <name>A0A183HMX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010320">
        <property type="protein sequence ID" value="VDO57649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMX5"/>
    <dbReference type="STRING" id="387005.A0A183HMX5"/>
    <dbReference type="WBParaSite" id="OFLC_0000883601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000883601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000883601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000883601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8465" checksum="F06BC091A3DAC208" modified="2016-09-07" version="1">MIHRKRLPSKISSESMEFFRSLPIYVGGVTATSASKIGVLSLIGCYRDFQLHGKHIAFKDAKKLNKVLPDGCPFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN48</accession>
    <name>A0A183HN48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Detected protein of confused Function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010464">
        <property type="protein sequence ID" value="VDO57974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN48"/>
    <dbReference type="STRING" id="387005.A0A183HN48"/>
    <dbReference type="WBParaSite" id="OFLC_0000890901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000890901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000890901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000890901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22451" checksum="ADE7B44F4E36EBB3" modified="2016-09-07" version="1">MNSRDKLWMGHKGSAFPLVAEAIQEEVEAYKNSEDEIKRLKHAMGMDDVESDETVSLLSDTTAKLTSTVGSLPEVLEKKRLIDLHTTVATAVLDQIKQRKLDVLFEAEEKIMNGLLSDASVMELMRQSSAHEDILRIMLINYLCSSNISQGLLKDEFGKELNNFDSGLNHLQDELREQADYLKEVGLDDAAVKYVKHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP00</accession>
    <name>A0A183HP00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011053">
        <property type="protein sequence ID" value="VDO59172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP00"/>
    <dbReference type="WBParaSite" id="OFLC_0000921101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000921101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000921101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000921101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13450" checksum="6CBCF28A3020BD20" modified="2016-09-07" version="1">MKLLALCKHETYRNNDRCFRIFLLATKILNDRNAMKMFSVFYNNKMFTQLSDFYICWAQRCDQNHSIIRAILIKAVRMDAKPKCSIDIRKRSLCLLQFSLRNATQYGEENSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP24</accession>
    <name>A0A183HP24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011120">
        <property type="protein sequence ID" value="VDO59301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP24"/>
    <dbReference type="STRING" id="387005.A0A183HP24"/>
    <dbReference type="WBParaSite" id="OFLC_0000923501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000923501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000923501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000923501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26954" checksum="377881EAA0FDC627" modified="2016-09-07" version="1">MFKTDFVGVKQRILTYLYHRCADSTQVDNFLHTFAQFRSLRMWQMQLVTPSIILIRFVNEEAFAATPGIGSYPLLLVLMDWQRGDILGAFDRYSANFLKLIEKCQEELKYAHVSSNRFPCTIQHCQQALVAYERMKDALTDARGGSDRETRRRIICQLPYSFSYIPVETPYLDPSMFRFDDRLITLIERTKLTDSEVIRLGFTTFYYFTGFQNQKVFSGVFYFNFSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP67</accession>
    <name>A0A183HP67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9277</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011215">
        <property type="protein sequence ID" value="VDO59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP67"/>
    <dbReference type="STRING" id="387005.A0A183HP67"/>
    <dbReference type="WBParaSite" id="OFLC_0000927801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000927801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000927801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000927801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7973" checksum="4CDDEBA9571B00DC" modified="2016-09-07" version="1">MRIFSNQFASIAVDSPISPVEVPLPGSISASVHSGTTGCSENDFRCNDGKCIRFEWKCDGSGDCPDGEDEKDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQB0</accession>
    <name>A0A183HQB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tho2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012122">
        <property type="protein sequence ID" value="VDO62364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQB0"/>
    <dbReference type="STRING" id="387005.A0A183HQB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000967101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000967101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000967101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000967101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11596" checksum="B278A68BB60F8DD8" modified="2016-09-07" version="1">MLFVFQLSEGKLEAIEEEGTDDDKKQIDRTKRCFRKATNNVIMDRRTYRCGFCNELLGNFDEETLSLCMIALETFVHREPAMAAPSLFRIISTVTRLIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQD5</accession>
    <name>A0A183HQD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9699</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012178">
        <property type="protein sequence ID" value="VDO62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQD5"/>
    <dbReference type="STRING" id="387005.A0A183HQD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000969601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000969601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000969601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000969601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25776" checksum="FA64E68D8C8AD680" modified="2016-09-07" version="1">MLNKYFYIWIAVSPQYTGERINSNICKADRWILTEGHLHDVGDEVCALLVTICMIADYTKHKLRDRYSDEKIRIKWDNSVLFVFSGKSMDQRAFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGAMDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREVQNFGICSGYLYYFLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQH3</accession>
    <name>A0A183HQH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9736</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012270">
        <property type="protein sequence ID" value="VDO62880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQH3"/>
    <dbReference type="WBParaSite" id="OFLC_0000973401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000973401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000973401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000973401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13059" checksum="DFE1C9E79F933A94" modified="2016-09-07" version="1">MENKEMERLKKFWNDIFSNEIDYSQFETRNGDTDIIVFREKSSKFMLFGTNIHVVLGATIAATIGLMVTIAFCIIYTFYHQREQGRNYFIDHLELGQSLLSIYNICLLFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRD2</accession>
    <name>A0A183HRD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012979">
        <property type="protein sequence ID" value="VDO65385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRD2"/>
    <dbReference type="WBParaSite" id="OFLC_0001004301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001004301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001004301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001004301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="46" mass="5436" checksum="8E5837B8F81677AB" modified="2016-09-07" version="1">MMMPAMRQLFYQMFLSNIPLRMNQLCGQQSILLLIILLYNGSILSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRT0</accession>
    <name>A0A183HRT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">POU-specific domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10190</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013319">
        <property type="protein sequence ID" value="VDO66543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRT0"/>
    <dbReference type="STRING" id="387005.A0A183HRT0"/>
    <dbReference type="WBParaSite" id="OFLC_0001019101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001019101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001019101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF70">
        <property type="entry name" value="INHIBITORY POU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="7">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO66543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001019101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18480" checksum="B11E0D31C81A052A" modified="2016-09-07" version="1">MAMQHYPTAQFSQYPIPSPFATATAVVASQSAAAAAAMPIYPLSTQTTELDTDPRELERFAEHFKQRRIKLGVTQADVGKALAHLKMPGVGSLSQSTICRFESLTLSHNNMVALKPILHSWLEKAEEVTKTKDVTGDAQGILPNLDKKRKRTSIAAPEKRLLEDYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRU4</accession>
    <name>A0A183HRU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10203</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013343">
        <property type="protein sequence ID" value="VDO66639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRU4"/>
    <dbReference type="STRING" id="387005.A0A183HRU4"/>
    <dbReference type="WBParaSite" id="OFLC_0001020501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001020501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001020501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001020501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27766" checksum="E8875F3EE520FC9F" modified="2016-09-07" version="1">MNIDQASCAKSYPETIILSELETAISETSNMETRFSPNFDCSVSEMKNSSQILNEVSDSNNYMEKRYTDIKTAEISKLSDTLELLTPKNSSKENDDASNLNIDSSLSAAINTASLLERTRPCYQSNKQSTYVVHRDETRETDSDDKMQITKRSTCSIHSRTTCLKYEQNTTDGDLRIVPMDLKSSSREFKSQADGDVAKDVEEKRGKVTSTRFPGRITLDGLEEQEYAGSVIILNSVMKLNYCYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRY5</accession>
    <name>A0A183HRY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013440">
        <property type="protein sequence ID" value="VDO66985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRY5"/>
    <dbReference type="WBParaSite" id="OFLC_0001024601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001024601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001024601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552618" evidence="1">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001024601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25934" checksum="64E31543EDFD4118" modified="2016-09-07" version="1">MFLIYPNLIVELTVFLYVSGITSDSTNKIFFDPDGLFVPWELYEYMRYDLLRPLAKLQTLRNISLYNSIRIELRRRGKNGGLKMLDIARELAIPGYFRELRALWNNYSDTKENDFEFAFIRIISFLYWANANIYPLTDLGPLNVEKLMLCYNCRWGETSTARKRFDTFMRQILFDMEDLLALRSWCGILREKTLFDVAMVRSEYLMILDLGTMVSKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSN8</accession>
    <name>A0A183HSN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS10504</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014057">
        <property type="protein sequence ID" value="VDO68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSN8"/>
    <dbReference type="STRING" id="387005.A0A183HSN8"/>
    <dbReference type="WBParaSite" id="OFLC_0001049901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001049901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001049901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001049901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14144" checksum="CCBC1EC81D99092A" modified="2016-09-07" version="1">MRVCGFVSVCVCCTYRSVRICTFARIFTYLCLCVRIGVAVCIFVYLDVIIKMCDESEPSIEGRPISEMKVVELKEELGKRGLSKIGNKNALYERLKEYLLTEINAKCESEVQSTAIESPQRDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTC4</accession>
    <name>A0A183HTC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10738</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014655">
        <property type="protein sequence ID" value="VDO70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTC4"/>
    <dbReference type="STRING" id="387005.A0A183HTC4"/>
    <dbReference type="WBParaSite" id="OFLC_0001073601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001073601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001073601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001073601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6523" checksum="A9C6C4B2F05F68D8" modified="2016-09-07" version="1">MFGNKEKKEKPDKETFKTVLSQDNFRQIQKLFSEYQSMTGEPLTAAVEVRLKISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUU6</accession>
    <name>A0A183HUU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3719 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11256</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016039">
        <property type="protein sequence ID" value="VDO75146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUU6"/>
    <dbReference type="WBParaSite" id="OFLC_0001125801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001125801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001125801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="2">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001125801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13965" checksum="5916B475B7E37929" modified="2016-09-07" version="1">MSSMNRRPSRIPISCRNELKQGKNQSCRKSIILQNNPISDGPETKEHFLIRAERSIYEGEPMSDDEVEVECRTWARTLPHLRICGKSINKNYSNKMKSMNEDIIDRLIQDFLWSPVSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUV8</accession>
    <name>A0A183HUV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11274</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016079">
        <property type="protein sequence ID" value="VDO75236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUV8"/>
    <dbReference type="WBParaSite" id="OFLC_0001127001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001127001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001127001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001127001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5012" checksum="3D20076522E9437C" modified="2016-09-07" version="1">MFHIDIFKDIPLSTLCLLGRPSIIAVNYQTKTTFRFNVGPSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW31</accession>
    <name>A0A183HW31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11689</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017210">
        <property type="protein sequence ID" value="VDO78477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW31"/>
    <dbReference type="STRING" id="387005.A0A183HW31"/>
    <dbReference type="WBParaSite" id="OFLC_0001169301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001169301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001169301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001169301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12292" checksum="1B448C5B19BDC874" modified="2016-09-07" version="1">MPDDFKASIKVKIDNHFFNKDNMPSHFKIKDYCPNVFRNLREQFGVDQNEYLRSLTYSEPEPELDQVDKSGPRLFVSYDKKFVIKSMDSEAVAELHSVLRSYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW99</accession>
    <name>A0A183HW99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017453">
        <property type="protein sequence ID" value="VDO79055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW99"/>
    <dbReference type="WBParaSite" id="OFLC_0001176101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001176101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001176101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001176101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5184" checksum="9D1FE03DA62D75BC" modified="2016-09-07" version="1">MLFTLEGTWSKYSNVACDPVEKLSLILCWDAPCTAITAFIIIVSFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWC1</accession>
    <name>A0A183HWC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11784</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017506">
        <property type="protein sequence ID" value="VDO79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWC1"/>
    <dbReference type="WBParaSite" id="OFLC_0001178301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001178301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001178301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001178301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13811" checksum="1ACC9DB2815E0470" modified="2016-09-07" version="1">MKINSLLRETFSSDERNDQMEKGAPKLSVNHNTDLNLKIGTDTWRILKSNEEFANNRNQSKWIKIHKHGESEQNHDNNKGQKQSDEKLKKKYGLNNGKQLQIRTFVFYLKNNFIHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWZ0</accession>
    <name>A0A183HWZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase-stimulating G alpha protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12007</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018066">
        <property type="protein sequence ID" value="VDO81105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWZ0"/>
    <dbReference type="STRING" id="387005.A0A183HWZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001200201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001200201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001200201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO81105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001200201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14101" checksum="EEE8E40613847D6B" modified="2016-09-07" version="1">MDLKVILKAMSEIEPPVQLDDRANAPSRDYLLSTSSEPDFDFPQVFYDHVTKCWTDRGVQACFERSNEYQLIDCAKYFLDKIGDIRQNDYNPSEQDILRCRVMTTGIFETKFEVDKVRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXR1</accession>
    <name>A0A183HXR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta-1 chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-1-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS12268</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018837">
        <property type="protein sequence ID" value="VDO83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXR1"/>
    <dbReference type="STRING" id="387005.A0A183HXR1"/>
    <dbReference type="WBParaSite" id="OFLC_0001227401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001227401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001227401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527:SF8">
        <property type="entry name" value="TUBULIN BETA-4B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001227401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17789" checksum="C3FF1F1CDFC3B160" modified="2016-09-07" version="1">MAACDPRHGRYLTVAVMFRGIMSMREVDSQMFNVQDKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATIEDEGEYDDTGNTDYNNEIETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYE8</accession>
    <name>A0A183HYE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039857">
        <property type="protein sequence ID" value="VDP11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYE8"/>
    <dbReference type="WBParaSite" id="OFLC_0001251101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001251101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001251101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001251101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7513" checksum="BA7F1AFE32E422DA" modified="2016-09-07" version="1">MTAFYKLHLSAEMVFVLRVEGWILGRILNFEQRGLAEQYRIVVLSDDDGDDDNSISVVDISCAHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZF1</accession>
    <name>A0A183HZF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4536 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12863</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039957">
        <property type="protein sequence ID" value="VDP12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZF1"/>
    <dbReference type="WBParaSite" id="OFLC_0001286401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001286401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001286401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001286401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11087" checksum="AAB6006D54F5B579" modified="2016-09-07" version="1">MQIYWIDNIIDYDIRNSTMSDEEKSNDCQSCRYIGSGLFSFIAAYLWLNTRNNIYSDTIYRKLPLRLIAVGSMYMSFARFFYFPPFKHLAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZQ8</accession>
    <name>A0A183HZQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12970</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039995">
        <property type="protein sequence ID" value="VDP12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZQ8"/>
    <dbReference type="STRING" id="387005.A0A183HZQ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001297101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001297101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001297101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001297101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61788" checksum="5CAED176FA61E5C6" modified="2016-09-07" version="1">MYDCFRRKVYDRQSGGFVTLNDEEVRKLNAINASKYPSVGYNPYQPFLDIFSSQTEIHPISNRPDSKRSFIPSLDEKRIVGKMVHAIKMGWVRPSRPKEIKKKVYDLWADDPFKEKTKSELSRIRMHFPAPKVPLPGHAESYNPPAEYLFDDEELKKWEETDPEDRRLDFVPKKYGCLRKVPAYDEFYNDRYQRCLDLYLAPRQRKMKLNVNHTELLPELPNLAEMRPFPTTQSFLMFGHSGQVRSLSFEPESAEIFASGGEDGTLRLWSIYDGRCLKTTNLETPVTSVAYCPIAKWTLIAVTMESTNMILTNSYCGDRHRIIATTEYLSKLRCESSGNDILKWKYEGKGKISINLGYIARQVVWHHKGLITALSFHPCEPLLFVGTQRYIRIYDLAKCQLKKKVMTGSQWMSSMHVDFRGDNVFVGGHDKIFSWIDLQLSSKPWKSVKHHTAAIRAVTQHARYPLIATVSDDSTAIVYYARISSDPFKENEFVPVRRLRTQTAHRNGLSILAAIFHPSQPWLITAHVDGSIALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZR6</accession>
    <name>A0A183HZR6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS12978</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="UZAJ01039998">
        <property type="protein sequence ID" value="VDP12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZR6"/>
    <dbReference type="STRING" id="387005.A0A183HZR6"/>
    <dbReference type="WBParaSite" id="OFLC_0001297901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001297901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001297901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="300"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDP12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001297901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="967" mass="108793" checksum="DF2D75FEA3EA7B66" modified="2016-09-07" version="1">MFSVKWGFSLEGHGEWVAQLHGSSSTLYKCLTKRYANPASVQEIRHLRRSVRKNTFKRMPAQATHSAHITVDDEHLYLWGYKTNRIKAALTWIVSVLTLGTFRLLLYWYPRWWVKCTASECSLSTADCLLIRDADMNVAFRPIICMISDAVMQLGLPVAGFRMADISTLRYFTFKKLLHLWYPDENRFISIDSLDVDIDFRRFHIMAEKGLSNADVAKRLAVYGKNLININLKPLHVLLFREVISPFYIFQLFSVAIWFSDHYEIYAAVIVAMSLFSIALDLYQTRKQERKLRSMVHSSAFVQVLRNGENLMKISSEELVPGDVILIPPSGCNMQCDAVLINGTVIVNESMLTGESVPVTKAALPDTDDESSVFSLKKHSRHVLFCGTQVLQTRYYAGKSVKAVVFRTAYTTLKGQLVRSIMYPKPIDLRFTRDLFKFVGFLGCIAFCGFSYTIVTMILRGADVRKVIVRALDIITVVVPPALPAAMSVGVLASHMRLHRKDIYCIAPSTINTCGAINVVCFDKTGTLTEDGLDFHSVCPVVHSDDKEPMFRHEFPSLNIKEMWSYRKLVEAVSTCHSLTCINGLLCGDPLDLILFKNTAWVLDETMNSRIAETARFDILAPPVVRSVPGACGCDREIELAILRQFTFSSSLQRMSVIVHDPEDESHDMTLYCKGAPEMIASLCQPSSIPANYSNVVNDYAQHGYRLIAVAYKKLYISFPKSQRVNREQVENDLTLLGLVTMENRLKAQTIDVIHQLNKAHIRTVMVTGDNILTALSVARECGIIQPIKKAYIVECGTRDSPNSRIPLLVKQAASSSEDLLDDSSSVYDMESRSFIDPAYQLSVSGPTFEVISREYPELLLKFVTVCDVFARMSPEQKQMLVNKLQEVEYTVAMCGDGANDCAALKAAHAGISLSEAEASIAAPFTSRIPDIRCVPMIIREGVTVIMAFSFRNIDIYIYIYIYIYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZY2</accession>
    <name>A0A183HZY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2235 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040023">
        <property type="protein sequence ID" value="VDP12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZY2"/>
    <dbReference type="WBParaSite" id="OFLC_0001304501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001304501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001304501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001304501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9123" checksum="DB9F41100C76EDC9" modified="2016-09-07" version="1">MTLLGKYFVDHLFGREIRDNWRYVIIVCDTAGSHDCGTGFGVLVMDLCLLNIDDRSMCKGLVVFVGGVFFVRAISDEWDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0W0</accession>
    <name>A0A183I0W0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS13372</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040168">
        <property type="protein sequence ID" value="VDP13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0W0"/>
    <dbReference type="STRING" id="387005.A0A183I0W0"/>
    <dbReference type="WBParaSite" id="OFLC_0001337301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001337301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001337301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001337301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37483" checksum="0D1F7BA78E788A20" modified="2016-09-07" version="1">MARTVDRNELHKEPSSFNIGPYKFTNCQLIGGGTYGTVYKAYDIKRQTHFAVKIIRLDSREGVPGTCLREVSILKELTHPNIVKIHSVIPSDGCRKIYLIFEHIDYDLKMLIEKLRPRILPMPYIKSFLWQLLRALTLCHTHRVLHRDLKPQNILVAVNGAVKIADFGLARSFTIPSRYYTHEIVTLWYRAPEILLRSRYYSTAVDIWSLACIFAELVTSVPLFHADTEISQLLKIFKILGTPTVEIWPDLLNCIDYKDSFPKWTECVLAEHVPGLDSDGLDLLAQMLLYPPEKRITTKAALSHRFLRDVPIHIESIKTLFGPDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1B0</accession>
    <name>A0A183I1B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13522</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040243">
        <property type="protein sequence ID" value="VDP13972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1B0"/>
    <dbReference type="STRING" id="387005.A0A183I1B0"/>
    <dbReference type="WBParaSite" id="OFLC_0001352301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001352301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001352301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001352301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="64620" checksum="5F4FA6679BA90CC8" modified="2016-09-07" version="1">MDDMEAFDTPPWEKFGRWVHCICVVTFDLELGQSIEVVYPGDAQLTVNEKSSICYLSFPDSNSGMARDTNFHFRIRRSSGCSNLSTYAAYSEHVPAAIDADPQYFYGFVHSRQKKDSSLPRGYFQKSLVLLTVLPLFDLFSLVVGVIAQGFFDSGEPAIEAACHHIDQWPIPIPGIVLCLPLMGNVIQCRIPCQIDIYSPQRNYLMNVKLMSPSKNPVLLSIMNKSNILGNLLFVVNNVQLLWELVLTGEPVVVLAQNPSECSTFVQSLTSLIWPLRYSSDYRPFFTIHDAEFREYSSRTDPWPNVILGVTNPFFTKIFQNWPHIIRLVPSQEQQIPVVGKRKKIWNKRILETKYGLFSQYKMFLQKDKTLFKDALKANNSDWRDATELQRRILDLTQNFMMPLENYVSSLMPLKKHLSPFKNVPQIYPFVVDNFFTALDETRIMQTSGIRGDWRGLYQKFTTSPNFQDWLSRRKADLERQLQLLHLEMLCSADFSRETLHKRPQVEVVDLVLKLNDRIQNLDETSESSRIRLQSQISAILASVDDDLKSVLLSNGSLRDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1U9</accession>
    <name>A0A183I1U9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13711</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040351">
        <property type="protein sequence ID" value="VDP14463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1U9"/>
    <dbReference type="WBParaSite" id="OFLC_0001371201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001371201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001371201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552733" evidence="2">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001371201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15527" checksum="199305AB92E43638" modified="2016-09-07" version="1">MFWIFLTVVTLTEVTCGIVINSFNGLTVGPSQLNGIGNDIPVSFNDLGSFGHVPTSVFTKSGVLPDPIPDPDTSIDSSQHDIDELGSFQHNIAGFGSFQNNAGMSLKTAELATTSDIPRNLAAVHSYSMVFLPLILIFLLTHFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I235</accession>
    <name>A0A183I235_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHYHIP_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040399">
        <property type="protein sequence ID" value="VDP14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I235"/>
    <dbReference type="WBParaSite" id="OFLC_0001379801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001379801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001379801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042868">
        <property type="entry name" value="PHYHIP/PHYHIPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045545">
        <property type="entry name" value="PHYIP/PHIPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698:SF4">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698">
        <property type="entry name" value="PROTEIN CBG15099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19281">
        <property type="entry name" value="PHYHIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytanoyl-CoA hydroxylase-interacting protein-like C-terminal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001379801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64808" checksum="B571F88BDC19D529" modified="2016-09-07" version="1">MWSEPDFPYPEIESAYRPVLAWQRRLPRYPLPYARPPDMPPPFMKPDINMIRMGIPPPFRMPRIPLELVTPHAGPGMPPPPLRPVRPPNVPLYQDFSAPPRPTPINISVQTSALKCNVEWKSPAVSKTLKYAYKLEVWEGVRCDTYDFPAHILSYKLRTTPGTVYKEMSSDSLLLRAIFIAATRIIFQLELSARDANNSVVALGTTCMKAVFSAEEMQALYKKSLDFVGTVMHSFRFLYRCKPKIYYDDIQFHRGGIMEKYMKDNNGQAASSINGAISGLFFSARLLPDGSLPTHSPFGNVRMLVPAMTLLDPARVNMYFCDFYCNYITHYVTVVICEKHSDVSYVVRLIKLAPDSNPFLRIVFRPPMFEPEFWVNKNVWVEIYYTENVPLNWGRFDAITATGAGTSRVGGLPHNKQCQMCNLYPQKNSSSAKVASTKLNSTFELLLHLERKRFGNENINESADLIETICSIIDSVVEQCSQNTENENSQQENDNEERGKRKLESPQEIMQRLDAQDLCEEMQDVKNYLRAFIDSMDKGLSKIERLLNDARQYSVRSTLLSQNCLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I276</accession>
    <name>A0A183I276_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog dnj-20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DnaJ domain protein 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13836</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040423">
        <property type="protein sequence ID" value="VDP14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I276"/>
    <dbReference type="STRING" id="387005.A0A183I276"/>
    <dbReference type="WBParaSite" id="OFLC_0001383901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001383901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001383901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051736">
        <property type="entry name" value="DnaJ-B11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00077014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001383901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39083" checksum="EEEA8C5B9D81C2D1" modified="2016-09-07" version="1">MLVSAGRDFYQILKVPRNASPNQIKKAYRMLAKKLHPDKQSDNPEAEEKFRDLCDAYQVLSDEKKREIYDRDGEEGLKNSGDFFDSGSFHEPFSSFFGDFHGNRQREEGIPRGADVIVDLWVTLEEVYSGNFVEVKRIKSSYKQTSGTRKCNCRHEMRTEQLGAGRFQMFQVKVCDECPNVKLVQEIRTLEVEVEVGVDEGQTQTFSGEGEPHIDGEPGDLKFVIKIQKHPIFERRGLDLYTNVTISLEDALNGFKMEITHLDGHKVEVTREKITWPGARIRKKDEGLPSYSNNNKKGILYVTVDIDFPRGEFSSEQKEVIKTLLNQGSFQHKVYNGLQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2L2</accession>
    <name>A0A183I2L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13975</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040510">
        <property type="protein sequence ID" value="VDP15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2L2"/>
    <dbReference type="STRING" id="387005.A0A183I2L2"/>
    <dbReference type="WBParaSite" id="OFLC_0001397501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001397501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001397501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001397501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20773" checksum="1A3518854356A412" modified="2016-09-07" version="1">MSTKHLRRYLQEKKAIEEKKSSVREEEQSSESASESGAFVCNKYEFLEESAEGGDESSGLVEEPPVEKKSEKKEKKMVKKKRKGKKKERYTDIDNDLDILDTSPQETQLSKLHDMIFERDLFKIDSRMLNVENELRSILGRRSIDATQRGRVVFGKIVKKKPTWPEIKNVGKIFFIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2S1</accession>
    <name>A0A183I2S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14033</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040549">
        <property type="protein sequence ID" value="VDP15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2S1"/>
    <dbReference type="STRING" id="387005.A0A183I2S1"/>
    <dbReference type="WBParaSite" id="OFLC_0001404101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001404101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001404101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001404101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35452" checksum="B221C335B1E5377F" modified="2016-09-07" version="1">MNCEGCKGFFKRTVRKDLIYLCRENRNCIIDKRQRNRCQYCRYRKCQSMGMKREAVQEERQSSRTDITKVLTNNGGQRQIITSQMEAESTSTYGGLEIQLERIAAAEETSEALFSNIKVESNDISSCESLEWQMIRMVEWAFMLPSFNEILVEDQARLIRFGWHELILADIAYRSTVNKLLLWPERVMERNDAEILGCRIIFDRIINELTVRMKDLDVDRMEIAALRCAILYNPSVSGLRNVSVVESLRDKVMVCLEDYCRQHHPAQTQRFAKLLLRMPALRSLSLQCAESDSFIITAPIIPVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4I3</accession>
    <name>A0A183I4I3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Elongator complex protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041037">
        <property type="protein sequence ID" value="VDP18011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4I3"/>
    <dbReference type="STRING" id="387005.A0A183I4I3"/>
    <dbReference type="WBParaSite" id="OFLC_0001465601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001465601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001465601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001465601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8436" checksum="189D245EA0C420F8" modified="2016-09-07" version="1">MEKFGDRFDGYFRLLKLPTIASIATHCPASSDLIFQLQKRKFDIRILHLPPALDVDDKKENFGSSCQEISKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4K5</accession>
    <name>A0A183I4K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF4153 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14667</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041062">
        <property type="protein sequence ID" value="VDP18137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4K5"/>
    <dbReference type="WBParaSite" id="OFLC_0001467801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001467801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001467801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP18137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001467801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42353" checksum="782061B0AC98D2E1" modified="2016-09-07" version="1">MDQLMSSSDRWIALQFSFYNALLLVLTGVCLAGLFAVYRMMYMFLTPLLWATLIGTILFPFKKRFNNAINGWLSRVDNEGKPLLVAVILMPYDAFISATDLFLIHLARREGIIMLGAYLVLKILNHITFVALLHFLGDLYRNTDYIILFCSRTWVSILMMLYFAAFVGWFFVQDQHSMNKKLARLISVPLWFFGIAKISNFFGPFNVIVMSGISATLIIIASGILIREEVKADNPEKTGYVNLKNTDEKLIEDKKEKTFDQELTGDFYLQAILGLSALEFAVQHDFVSVCVLFLAIFTVMRKIGTEINVQIDLTKKCCALWNLFQENTQQFIHVTIAGSIRNYFKLIFSSDQMVSFYWCSFLVFSSGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Q8</accession>
    <name>A0A183I4Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041122">
        <property type="protein sequence ID" value="VDP18408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Q8"/>
    <dbReference type="WBParaSite" id="OFLC_0001473101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001473101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001473101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001473101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10389" checksum="C34299FDB07441CA" modified="2016-09-07" version="1">MTMTFPIYRLMEVFSSSFWLHNLRDLSCKNDPQHYGYWGIRIYAEIMESRPISVSKPHIHIHIHTHTHTHIDIHICSNLPRPIPGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4W6</accession>
    <name>A0A183I4W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14778</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041184">
        <property type="protein sequence ID" value="VDP18721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4W6"/>
    <dbReference type="WBParaSite" id="OFLC_0001478901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001478901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001478901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001478901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3521" checksum="A075C3EBFBC27B97" modified="2016-09-07" version="1">MKENLVLRGAKRYQIAIYIVWEENIIFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5D1</accession>
    <name>A0A183I5D1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle subunit SRP54</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Signal recognition particle 54 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14943</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041387">
        <property type="protein sequence ID" value="VDP19686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5D1"/>
    <dbReference type="STRING" id="387005.A0A183I5D1"/>
    <dbReference type="WBParaSite" id="OFLC_0001495401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001495401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001495401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="8">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP19686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001495401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31018" checksum="92D7FA10F1527F8E" modified="2016-09-07" version="1">MDASIGQACEAQARAFSETVDVGSVIITKLDSHAKGGGALSAVAATHSPVIFIGTGEHIDDFEPFEVKPFVQKLLGMGDIEGLVKKVNEIGIEDNEELIKRLKHGMFTLRDMYEQFQNIMKMGPFNQIMSMIPGFGPDFMSKGNEQESQSRLKKLMTIMDSMSDAELDHPKANDLFSKEPGRIQRVARGSGTATSEVKELLTQYKKFADMVKKMGSMKGLFKNGDMNTKNINPSQLQKLNQQMAKMMDPRVLQQMGGMGGLQNMMKQLQGASSSLGNRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5M8</accession>
    <name>A0A183I5M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GYF_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041526">
        <property type="protein sequence ID" value="VDP20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5M8"/>
    <dbReference type="STRING" id="387005.A0A183I5M8"/>
    <dbReference type="WBParaSite" id="OFLC_0001505101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001505101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001505101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001505101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12921" checksum="DB78986B69377FE1" modified="2016-09-07" version="1">MDTGQPISIWYISGKQIGDMPSDLAAGLKAETSELELIEKDLASTHYINNQQNIHPSFHSASKHSGFPFNETILPKSASPVSFNITDSGGGDNVKKNSHNQVLSFILIIFFFWNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5V0</accession>
    <name>A0A183I5V0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator complex subunit 4-like HEAT repeat-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15112</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041627">
        <property type="protein sequence ID" value="VDP20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5V0"/>
    <dbReference type="STRING" id="387005.A0A183I5V0"/>
    <dbReference type="WBParaSite" id="OFLC_0001512301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001512301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001512301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001512301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="59799" checksum="414A904FB6CA0AA6" modified="2016-09-07" version="1">MFVDNNAEKTFYAKYQELLHPQAIRMSENKFNERHEKNQQRINNFRSELAEICKNKQQLYHWRQVDSARTFLFTFHRILFTTEVAEVFLQMLIDVRSRWRRIAAECIASYLEWNKPLTKRILWDPPDKAILASKKFTNIYFDNQLPQNYRFEIQTSQFFRPDNLSIVYDSTRLPKNEQTWNETIFISKPYWGAYQWPKKLMVLAPANTQTELHRSMSEFNDVEKLILKHMKDEQFLNSWHTILLKEMEDSDVFYTSEYRFVKYLFRNFGISLVPQFKMLLESLCSCENERPVIRRARAKLAAIYCAGIIRGSRNWLFNNLQEMWVWLKPIIVYQIEGLMSETVSYWNAVLNFCLNLTDLRKFHWLVETIFEITLRSSPTAWHRCVRLGLAQYVSSCSTWKATELLNRVIHIADNMISQAWLAPERDQIAKLGFKKREKSFSVLSFPAIYGFAMGDESNIPVKYRIPKLKEIMNIFDTHVILFQLLQLTENRYVSFFFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6A8</accession>
    <name>A0A183I6A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041861">
        <property type="protein sequence ID" value="VDP21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6A8"/>
    <dbReference type="WBParaSite" id="OFLC_0001528101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001528101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001528101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001528101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11441" checksum="26A9846A08E50A0E" modified="2016-09-07" version="1">MLRWGTIVPVLSRDKSHSEVIDLNDLLMLMVVGRWPNGYGGYGGPLIVLIPVGGAAGQKEMLRNQWLHISLLLLPMSMSWMKPQRNDHSQLQHFIHILTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6C6</accession>
    <name>A0A183I6C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">28S ribosomal protein S22, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041890">
        <property type="protein sequence ID" value="VDP21173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6C6"/>
    <dbReference type="STRING" id="387005.A0A183I6C6"/>
    <dbReference type="WBParaSite" id="OFLC_0001529901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001529901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001529901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001529901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42134" checksum="BE21B2875EE0BC21" modified="2016-09-07" version="1">MVVTRNLWRLLVRSKNCNHVTIQKNFYSAWIKCTEMAETQQAGGSNSIDVERLFTRSDIQNLLKHLTGLNLKEKLFSNRQITQPQRAHYALMTDEAYEKTVKSMEEIGKNFLQFVPVLEPRSNVPIVLANDPEIKGFDSSKYVFTDLSFGLGVQVRSVVVRETDGTLRSATPEERDRMTRVYKGHPYRPIYEPPLFKDPYLQMALDRDDHEYVLDWACHYYLPNDPVFIKLCHMIFDRTVDENKFANLYSTRHFGPFVFYLVLNNKFSPLLNHYAVEKRTEDAANLVRLIKTIFPDEIWSCQMKDADDLKVLQLYAKENIEYEAIVNDLIKAAEKKQKELKTSGSEISTGMKSEKDENKVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7J6</accession>
    <name>A0A183I7J6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1713 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15708</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042681">
        <property type="protein sequence ID" value="VDP23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7J6"/>
    <dbReference type="WBParaSite" id="OFLC_0001572101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001572101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001572101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001572101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18810" checksum="3349A67F08936776" modified="2016-09-07" version="1">MISEAAFGEEGEIMERPEIRAERCKLLNAPFFMAFILKIILLDLLLLLILIIIIIYHRSHIIPARRRYKIKMGILKHRKKRKLRDRARRRLRRLNILRRRRKKFQQEKEAQRQAEFLAKAVGVLGAAKAAEEKKKSSSTSSSDLVTAGGIPTTNPDQTNPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8E9</accession>
    <name>A0A183I8E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16011</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043588">
        <property type="protein sequence ID" value="VDP25963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001602401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001602401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001602401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP25963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001602401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17618" checksum="248116563963DE7B" modified="2016-09-07" version="1">MLLVAIFKSILLSYSAMGIFYTFKSITAIFSSWSRTNWLECVYEGHSYCYDPYVQCNEXXXXYYSKCYNLQLLSNRKNLNYTWEQVVIAVTSTSEALREFPPIIYWKEKINKPTRISEFFVASATVEQAIIAMIAILGIRFYSKVPSLFSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UGL8</accession>
    <name>A0A3P7UGL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000905">
        <property type="protein sequence ID" value="VDO30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H2S4"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="278" mass="30469" checksum="7E94BB21FAECA899" modified="2026-01-28" version="1">MTADLLKLCDPTAYYNQFLSESIYPDGRSINSFRPILLRMGVNGRSSGSSFARQGGATVTCNIEALLAPVSDAPIIVPLIQAAPNIPKNLVEDAMVMVNQLVAQNAFCTRDALKTAGGRLTWLLNLHIMILNVDGAICDALCTCIAGALVDLRLPDASTDCEEDIPIDINKVKLSETFHHIEVADIPVSSTFIVYKPPNEEVKVLCDPVSELFRIAPNTVMIVVGNNARIHRINQSGICGDEITMKHMVKMAVGRQKVVSESMLKAKESHLMKRKEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UPQ6</accession>
    <name>A0A3P7UPQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001611">
        <property type="protein sequence ID" value="VDO33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UPQ6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="86" mass="9827" checksum="6111A636F0FD2B48" modified="2019-02-13" version="1">MSYVLKDEQLNKYNHQKLIFLVITGLPAKSCRNICKSSLFSPIDNVPHTAPPNDQKSINFSFDFSDESDIDNRLTTEAPLFFYAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UTX8</accession>
    <name>A0A3P7UTX8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002820">
        <property type="protein sequence ID" value="VDO38326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UTX8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44515" checksum="891856D98E10EC39" modified="2019-02-13" version="1">MLNQNAEIIEPTTVFDENDPIVSSTGCHACASTSDDISIRFGGRNSIWKKSKPPRRNFGVQNVSKRDSRDSISCSAVSSEDSGNKRSSSKRHSERLPLQRIYGHQQQQALLINPPDGSDFKHQRPEERERFSEILRNKLDKIAYRLEQYKHETGIEIFARDLDQLAITTTEGNDEVDSVISNDSLDKYEQRMNAECDMNPAKEEKRRSMSASPIRFTNTLHVDHMSNPYGRHGFAPPPGGVTYKNYRNCATNHELHSLRSTTPLSSNDYGGHRYSDSSGFCSSESANIINRAALFEKARHMAMSTQTTTSFPQSCSEVSTSSFYYYSFPFEQQEKRSLFVNNLYPKKQQLVISYKEENAEAPFVAKLEMRDITFREFRRCFGISSKTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VHU2</accession>
    <name>A0A3P7VHU2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006498">
        <property type="protein sequence ID" value="VDO47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VHU2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="215"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="394" mass="46371" checksum="DF62225E7C29C0BF" modified="2019-02-13" version="1" fragment="single">MKRVRQLELENERLNVRINESEVVEKKERHDLVARYEAKVKELRDLIDDALKEKTRVNMEAKSALAERDNLRARIGKLEKELKQSEKLRLSNDSLIQDLQARLNSADNMRRHLEDENKNLLAENEDLKQQLEILRKQVEDEALANTALHNQNQSLKEDYDFLKRTHEGQLEEIHRKRQVEMTTTAREIERTYESRLQEQLQAMRAEFDERLNKNRRDIDETYKNKLNEANEARQQMNLAKEEAARLRLRIHEVEKVGSGYESRIEGLNKKIADLESQLRFVRDDCDVRISQRDKRIAELQGEIDRLLTEYQDLFDLKVQLDTELKAYQNLLEGEESRLNISQQSSGGSPAVSPTAGDRFSLSYTDSGHRRAIKRKRFNASDDSLYYRNTAKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W8J1</accession>
    <name>A0A3P7W8J1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003179">
        <property type="protein sequence ID" value="VDO39503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W8J1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="148"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="302" mass="34026" checksum="B74568726C881D06" modified="2019-02-13" version="1">MQVNQTFHAKDLVGGYKYSVVLYKAQDSPLLLYMENAEQLASALFSDATSEQLLRSGSTLIADAFSRLSIEITTDVTIPSLTSGYFICEYDRMPWDMEGMHFNEPFGSMPKLLLKQVKKHGPLPEVSSELLPVEVRTRTEHLPDFNDELYFKRLQTPRLGKALFYFPVCETTMEIGKSLAFAMAEEPIVVVARQQIKGVGRSRNQWLSPVGCAMFSFNYMLLPESSLNNNVGIIQHIFCVAIISGIRSLRKELENLPLKIKWPNDIYYGRMYKVGGLIVNATSVNEKTVCTLGDTISFKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WAQ1</accession>
    <name>A0A3P7WAQ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010526">
        <property type="protein sequence ID" value="VDO58130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WAQ1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF1">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL SUBUNIT B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO58130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="123" mass="14547" checksum="A929E958ECDAAA34" modified="2019-02-13" version="1">MTVPDREYLIWLTVVVIAFLYNAFGIPLRSSYPYQTKSNLIYWLIADYIADTIYLIDMLVFKPRLRFMRGGIPVKDMRETAKRYLHSNIFKLDLLSLMPLDVMYIWTGPIAAWRAIRMCKVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X2Q7</accession>
    <name>A0A3P7X2Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS47</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000011">
        <property type="protein sequence ID" value="VDO24328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X2Q7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="156" mass="17670" checksum="DC6BDA3F062E9720" modified="2019-02-13" version="1">MIFILHYYFQSGTVIVEAIRCYSCANDFIVWHWRHFFLKRNYGITTSDQSCPKSDYTPEITQFCPSTCFIMYLNGTNRHSGVVTVLALRGIIGTVRGCSSQFLTNDQHSQLGLGPHSRVSQIGNYLPSEFDMNPHQSDASTFSTNTFPTMLPTKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZI25</accession>
    <name>A0A3P7ZI25_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM C-terminal PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007262">
        <property type="protein sequence ID" value="VDO49542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZI25"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF2">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM C-terminal PH-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="90" mass="10081" checksum="DA99F4730893A399" modified="2019-02-13" version="1">MSIWQFFRVIQSSGNANSILDNTGCLDSDDELAKAVKDPTTQRSVASSAVQVYAFYCDTNFLCKTIWSTAISLHQFYLDQRTCASTKTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ARV6</accession>
    <name>A0A3P8ARV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040108">
        <property type="protein sequence ID" value="VDP13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="76" mass="8580" checksum="497E24030EFB1C76" modified="2026-01-28" version="1">MLLIGDKRFSTNSGNPRVYGRGAFETRRPVRLDVRKIPASMVRKIWSSSLIGIVSTFTIISVLHVLICRDSVPCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AYE4</accession>
    <name>A0A3P8AYE4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS10553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01014183">
        <property type="protein sequence ID" value="VDO69398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AYE4"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000328">
        <property type="entry name" value="Cyclin-dependent kinase 20 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO69398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="212" mass="24623" checksum="EBB5816A210CE136" modified="2019-02-13" version="1" fragment="single">MLQEDIQKRLSLPADLRLPLSVIEKLNRTPTLDQPLTRKNRRASLSEIGFGKLETYEKLEKLGEGTYATVYKGRSRLTEKFVALKEIRLELEEGAPCTAIREVSILRDLRHANIVTLHDIIHTERILTLVFEYVDRDLKQYLDECQDVISMKNVRLFLVQLLRGLNYCHQRRVLHRDLKPQNLLINEKGELKLADFGLARAKSIPTKTYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CHR1</accession>
    <name>A0A3P8CHR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041038">
        <property type="protein sequence ID" value="VDP18015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CHR1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31347" checksum="7AEBDFC1FE945F15" modified="2019-02-13" version="1">MYFIQCRDEVLSYNRYYLYITCRYFHDYIDDNPEENSINLEFESTAVEQVLSFAFTGLCQIKYYGGSFDSSDFTNYHQFLACLHLLKPLMYQELLQKYDDDFCRIFQKQCNKIRPPCEATTLQFLRLAIRLGFPKLEASTIARIVAVFPDTYSSHLNVDEQPHIINEMIQTRHDYEMYKERDGLADSTAPQLSPLERIELLKIKCKQVFKWIGQGLMSDMSEPKLPPPSTLAERNVFEHPPMQRLSLTYDATEKIDRKKKKYTNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8EVZ3</accession>
    <name>A0A3P8EVZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039855">
        <property type="protein sequence ID" value="VDP11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="137" mass="15671" checksum="30218AC057E2EC07" modified="2026-01-28" version="1">MHMGQEEQDVTGSYRLSVPMHRTKSVFIILESMGWMTVTAIMEDETLPLFYLCPVDCHPILHHPSLIILLCVLCTCAVARYYIFPPVSSTYSENCGSVHRSDRYKHPLQPYGIGASTGAFFTLTDEQRRILRFSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXV5</accession>
    <name>A0A183GXV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS65</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000015">
        <property type="protein sequence ID" value="VDO24386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXV5"/>
    <dbReference type="STRING" id="387005.A0A183GXV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000006401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000006401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000006401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001348">
        <property type="entry name" value="Ras and EF-hand domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO24386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000006401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28667" checksum="F4BECCB0829812B4" modified="2016-09-07" version="1">MTFSTIILPSATASPDELNNKLKRLCFSDNELALKYKNSLLNDYENRVPAAITEFGESTGLPERTFRVVMCGDAAVGKSSIVTRIIKGTFSGNLHSTLGVDFYVKVVSIDGKNVAIQLWDTAGQERFRSLCKSYFRRADAAILVYDCTAEGTFLNVRDWIATIKESSMRHIPIMICANKIDLRDIQLTRTVSTKDGKAVAVAMDVLFAECSALNGTNIEGALMNLIRELVATEDVEISETGVIIMSKFSKKTSHSCCLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYE3</accession>
    <name>A0A183GYE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Imm63 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000072">
        <property type="protein sequence ID" value="VDO25151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYE3"/>
    <dbReference type="STRING" id="387005.A0A183GYE3"/>
    <dbReference type="WBParaSite" id="OFLC_0000025201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000025201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000025201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000025201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10445" checksum="2A524CF669C2EBCD" modified="2016-09-07" version="1">MKSDRIFTVYSFVNKVWSLLLNMYDAIDEYLDQYDGQHAYDLIKEMISDDEAPNAELAYRFAHACYILSNSRLSKEGERYRLLKEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZH4</accession>
    <name>A0A183GZH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS634</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000225">
        <property type="protein sequence ID" value="VDO26492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZH4"/>
    <dbReference type="STRING" id="387005.A0A183GZH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000063301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000063301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000063301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047549">
        <property type="entry name" value="BICC1_KH-I_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24234">
        <property type="entry name" value="KH_BICC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO26492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000063301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="67277" checksum="15CDBACA08692397" modified="2016-09-07" version="1">MSEEERVYETGEENSKNMRLTIQDKISNDQVEEQIQVDRKRLESMITGEPLYGSEKFLPSAEEFFQKVTELSGAVISWPSRLKIGAKTKKDPYVKMLGTIEQVNCARQLIASTLRIKRDKISLRIEIPHCDHSKIIGRKGKNTQDIVRDTMCHIHFPDSNRIHDMEKNNQVSISGTVRQVEKARQRLRKLAPLCIICELPNTCRYSFQELQRSIGHPDIFVSLREERNGKMKCILKGIEQNEVEMVKAVMILANMYQIQNDYGLLCHTVISSHNCLESLLRDEVKKEEMQWLAQQTSTHIIQSSTVENGFELFIVGPIAGILITRKYIIASFGLLPVAVQFDRILESDQDLIDKALIEAKFGITINEKWRKSRTLVVLSSSEMNICMLYQARERILNLVQNSLNTVPDIFELFKNGHISTLVENMRIEAQQLLTGTNIESLYIATQKSLQKPTFPNFEGQCRLAEALVDVPTTDINRYAQITPNPDDSPIAHSLLAGIKQIDMIRNGNERFPTREQLLLKANRAVYNGTPAKVRQPTDLWAGYGFSNSLPADILRSSLNFFDSTTNQYDGRSNTQQETNLMDGVVCNFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H017</accession>
    <name>A0A183H017_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS828</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000330">
        <property type="protein sequence ID" value="VDO27246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H017"/>
    <dbReference type="WBParaSite" id="OFLC_0000082601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000082601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000082601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000082601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6872" checksum="6C87599866ED2F96" modified="2016-09-07" version="1">MVVASCNAHFPEVEDEKVLLKMMTAMLIRMERTLRELPSVKLCQTLIKPSSPLSIKDTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H023</accession>
    <name>A0A183H023_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000333">
        <property type="protein sequence ID" value="VDO27267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H023"/>
    <dbReference type="STRING" id="387005.A0A183H023"/>
    <dbReference type="WBParaSite" id="OFLC_0000083201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000083201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000083201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000083201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14133" checksum="9591A6BB7496EDF9" modified="2016-09-07" version="1">MRDSNRAIVFCSFGSAERRQQETGNQYQTRLHVQQSRDYNRLAFRYKLADDYKLSLHVLICIITEMSSYCKVLKFNGKTKETCCVAGKIKILVEPPKSIKNFASGFTADSKHLSTIKKYNPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0B3</accession>
    <name>A0A183H0B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS923</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000376">
        <property type="protein sequence ID" value="VDO27583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0B3"/>
    <dbReference type="STRING" id="387005.A0A183H0B3"/>
    <dbReference type="WBParaSite" id="OFLC_0000092201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000092201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000092201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO27583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000092201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41742" checksum="E799D5638B3F0EFF" modified="2016-09-07" version="1">MLEYCCLPHCTMQAMSFTAYAEKREEVTKGHGMYGCLACLFLLDAPGQQQSIVNTHFGPSIIVLLLSSSSLWRLLVQSLNFWWGFKEPGCTLLASFVSNLCLIARHWLSPQPMENFGHCKSCSKGEHNCTNYGTRSGHQCQCQGIYLSNLFQRIFCYHLPPSPLNQVSIFFPDLVEESARRLGLRLNLSIFKWDGSGYRPRLAEERDSLDRIVAALKAIIVVLCICVCLFYVLLVVCFVIELNCWAIERGTLKARLDDNGFCSGNAVILLNKPIHGEEQPKQRVRKSRYRHARVRYHSPPTSESDSNSRSSSSQHDDSGSFVLESSFQRRKRRLAHARRFGIDPPSQTVDAEKSQLAVICVVKAFLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Z5</accession>
    <name>A0A183H0Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000503">
        <property type="protein sequence ID" value="VDO28440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Z5"/>
    <dbReference type="WBParaSite" id="OFLC_0000115401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000115401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000115401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000115401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28081" checksum="C2E8D0AFB0D2E0DB" modified="2016-09-07" version="1">MFIFQDSNDLRRITFEQICGGQTFIQLGVCSSAYIRCSYNSIHHSVSAILEECPIGKIFNGEICEVAQNNCINKWNQRMERINSETEKLLEQLLSSQEMNFCHDVGAGIYMFTKVICSRQAYVCKNFNEGFAITCSPGMIILSRPFGCFVYPSSCERNKISMKQFAPLRHYAIEMRCRHFTKRNSEIMKFPTMQCNTWYVRCGKLIKDIIYCENGYIYDGKLEKCRLRNIHDRCMMPDLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H171</accession>
    <name>A0A183H171_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000546">
        <property type="protein sequence ID" value="VDO28749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H171"/>
    <dbReference type="STRING" id="387005.A0A183H171"/>
    <dbReference type="WBParaSite" id="OFLC_0000123001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000123001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000123001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000123001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17026" checksum="B097D240C16754F0" modified="2016-09-07" version="1">MVTKAETRLKTNIPKYEIASAVSRLMNEVAKDRLIKKKSKLDLKNKASLRNTSQPAKVIKNDKKIKKIGKKTQQRSGLIRKKLFTNHWELRCNNMLELMMCNKGPDLLSLKTFRKWYANGPQMIRDSSFSCICGSKMVKRMWHIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1H6</accession>
    <name>A0A183H1H6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">OFLC_LOCUS1336</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the oligosaccharyltransferase (OST) complex. There are 2 OST complexes, OST-A and OST-B, which contain STT3A or STT3B as catalytic subunit, respectively. OST-A and OST-B contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, and OST-A contains DC2/OSTC and KRTCAP2/KCP2 specific accessory subunits. OST-A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the OST-A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The OST-A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01000610">
        <property type="protein sequence ID" value="VDO29160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1H6"/>
    <dbReference type="STRING" id="387005.A0A183H1H6"/>
    <dbReference type="WBParaSite" id="OFLC_0000133501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000133501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000133501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000002">
        <property type="entry name" value="dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF43">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="523"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDO29160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000133501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="75767" checksum="81973B4C679E108A" modified="2016-09-07" version="1">MSVSIARLLRLTHDKQETFLKILILALAAVVSFSSRLFAVIRFESVIHEFDPYFNYRTTRYLTDEGYYNFHNWFDDRAWYPLGRIIGGTIYPGLMITSALIHRILHFIHFTLHVREICVFLAPLFSSFTVLITYMLTKELKDDAAGLVAASMIAIVPGYISRSVAGSYDNEGIAIFCMLSTYYLWIKAVKSGSVCWSVLCSLGYFYMVSSWGGYVFLINLIPLHVLALICTNRFSNKIYIAYSTFYIIGTILSMQIPFVGFQPVQTSEHMLSFGVFGLCQVIAFANWLRARMSERNFQFLFRSTVLFAACAVAMSVIVASYLGKIAPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTAWSSFYFDLQILVFTFPVGLYVCFKELNDHNIFIILYALTSIYFAGVMVRLMLVLAPVMCILGGIALSSTLSTFMKNLDSSSAHARHDKKEKEKNYPYKNEVAQAVIAIVAVFFISYVYHCTWATSEAYSSPSIVLSAHGGDGSTIIFDDFREAYYWLRKNTHPEAKVMSWWDYGYQITAMANRTVIVDNNTWNNTHISRVGQAMSSKEEDAYEIMRELDVDYVLVIFGGVIGYSSDDINKFLWMVRIGGSTPEGAHIKEMDYFSKSGEFRVDREGSPTMLNCLMYKLSYYRFGGLYTQHVSLFFGKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V7</accession>
    <name>A0A183H1V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1467</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000696">
        <property type="protein sequence ID" value="VDO29645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V7"/>
    <dbReference type="STRING" id="387005.A0A183H1V7"/>
    <dbReference type="WBParaSite" id="OFLC_0000146601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000146601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000146601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06969">
        <property type="entry name" value="NR_DBD_NGFI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000116">
        <property type="entry name" value="Nuclear receptor subfamily 4, group A, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="218"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO29645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000146601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="50685" checksum="DF626A41758A7861" modified="2016-09-07" version="1">MKIPSGSTPIGKFEFPRPSIASQQPELMQSSFASPGFATSSFVDPTHSQPPPAHQRIDQSTTAFQFPYATVVPTAITSEHHRANQQSLRCLLFPLLLQRNGPSNLQAVPPANESLSSDKLCAVCNDRAVCQHYGARTCEGCKGFFKRTVQKKAQYVCTGNKNCTIDKRFRSRCQYCRFQKCIAVGMVKEVVRYGSLSGRRGRLPSKTKVQHSDDPPSPPLPLLTLINKAYVESKTIVTPTLYNGSTEQLLSAMDEEFRFLLLFVEKIPNSTEISQNDITKLIERNFFALLALKLCYGWTESNSLHMEQIEVDIAAVPQPLKLLFSLMQEEAKRFQQVIQWDSPSFSALLALQFLNTKECGGELLSSDAAVDRLRGTITSALKDHCCNSSPPHTKKLQTIIAQIEMFARFQRIGQETLSLVVSSGVQLPPLMSSAAQSAQRFPGPSKLDFTEFSFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1Y1</accession>
    <name>A0A183H1Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THO complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1491</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000711">
        <property type="protein sequence ID" value="VDO29740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1Y1"/>
    <dbReference type="STRING" id="387005.A0A183H1Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0000149001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000149001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000149001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050290">
        <property type="term" value="F:sphingomyelin phosphodiesterase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14724">
        <property type="entry name" value="mit_SMPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO29740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000149001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="637" mass="74249" checksum="85957E4F826D2866" modified="2016-09-07" version="1">MDIYDNYPSRLSIAYNELLPRIQSQIYALDTYFLQSAIDRIFNDPQIDLLSVLSQPGINDSGNEYDQVVELVGTNSIIFKLLLESNAEIFEYFMFSFCRHLERSSCTYPSKIVQDSVYMRLLADYVCFMMPVNDENSVTVTAKKAYPENTMRSSYSTPLNLFKEEALRQYALCPSSHSIRTLRTMTQSISPHFLTFICILVRSYCSLSNWPTDYRFIALRFVLKEIHVFSLAESNDFNFSQSKLQLQWNAPFADELFDFFLSLFSRWPPNPSFTNLFDVWVTWIRPWRYCGNDLQRVMPFIRSNRRYYIELSDAFWRRKFSLECTQDIENLASYICILTSPDMLEVYEALEYNLESNVLTLMNSLKKDAEDLCLRVLKGEESLEKASWLQRTFFCLEEELLLSEQKRTLEALERLIMNASKAMSDAGYGGLQNIIFAIFAMRANKIMVISGNESFVNTESASNSHKSLSSFSPLSRKQVPDYYVDSATKLMYLTPLGRKQVARGTHCFDYSKCWKATPPIISSLRSDEVWWLSRLLYQISRAINRTRFIQNLSQCYQDSTVTGFIARFLLDPEYPNVYVPAHSSIVAFQKPCLNLRYLAFYRNLIPICVFFILLFFLPFSYCSITLFCMILYSRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3D2</accession>
    <name>A0A183H3D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1995</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001069">
        <property type="protein sequence ID" value="VDO31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3D2"/>
    <dbReference type="STRING" id="387005.A0A183H3D2"/>
    <dbReference type="WBParaSite" id="OFLC_0000199101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000199101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000199101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000199101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11294" checksum="A23AC1772E2392E9" modified="2016-09-07" version="1">MTEVEKYPLHRAAFFNDTQSIVHLINNGADLRLQDPQGNTALHISTMLGHKAFPIALYMQVAFSEAITILLAHNAPVKSKNRDGWNSLMEAVSYGDRQIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Z6</accession>
    <name>A0A183H3Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein lin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2206</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001221">
        <property type="protein sequence ID" value="VDO32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Z6"/>
    <dbReference type="STRING" id="387005.A0A183H3Z6"/>
    <dbReference type="WBParaSite" id="OFLC_0000220501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000220501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000220501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="203"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000220501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="31962" checksum="EBEBBDB75EA5B678" modified="2016-09-07" version="1">MDHALRTISYIADIGDLVVLMARRMSQSSKEEESFSISTPRVICHVFESDEASFIAQSIGQAFQVAYVEFLRANGIDDPSYLREIDYQEVLSSQELMGDELEMFAKKETQKDVVVPKKAGEPLGVVVVESGWGSMLPTVVIANLQPNGAACRCNHLNIGDQIIAINGISLVGLPLASAQQNIKATKSSTAVKLTVVSTPPVVEVRIRRPDTKYQLGFSVQNGVICSLLRGGIAERGGIRVGHRIIEINSQSVVAVPHERIVNMLASAIGEIHMKTMPTSMFRLLTGQEVPNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4L9</accession>
    <name>A0A183H4L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2429</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001396">
        <property type="protein sequence ID" value="VDO32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4L9"/>
    <dbReference type="WBParaSite" id="OFLC_0000242801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000242801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000242801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000242801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30113" checksum="BD1AC10ED80D4D88" modified="2016-09-07" version="1">MSAFSPFLLNEVLHLNITDFSYQTIRLLMSSKQRETTVLRPSLKKQQAQAQARSKDSDAKRHVTFATPKLPSFKCNLPKQQLTSDQSISKSRKQKSVDAHRKRIPSVELVELRTKKNKHNEQIIRLCEAQEALVKSSYVIRRMGKEAKEQETAATALLQNAVLLIETDVLRSFEAQKIGDLLDNVEQQQHKIAQDLCEGTSGYNEKIASIEKALAAIGKCNEMLDMQFTFEENKEGFSVAEEMKLLSTDIGLYLDILESLKEFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Y3</accession>
    <name>A0A183H4Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNNM transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2543</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001482">
        <property type="protein sequence ID" value="VDO33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000254201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000254201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000254201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000254201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10113" checksum="09503C41FCB4CE69" modified="2016-09-07" version="1">MHLLLFPLSVLDFERNREDFKTLKTREDRCWGILGICSRENLIALSLHVASSFITCNVTTNAVGLLLFKLCDNVEGQPPSASLPTNEQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5D6</accession>
    <name>A0A183H5D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2696</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001606">
        <property type="protein sequence ID" value="VDO33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5D6"/>
    <dbReference type="STRING" id="387005.A0A183H5D6"/>
    <dbReference type="WBParaSite" id="OFLC_0000269501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000269501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000269501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16989">
        <property type="entry name" value="ENTH_EpsinR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="1">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000269501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31948" checksum="669E8A12B802737A" modified="2016-09-07" version="1">MWGRMCRFTGNSSSISEIMSDLLSGIASFTKTVADSFNSYEIRKLGDKVQGMVMNYTEAESKVREATNEDPWGPTGPQMAEIAHMTYQYDTFPEIMSMLWKRMLQDNKNAWRRSLTLLHYLLKNGSERVVNNARDHLFEMRTLESYKFIDEKGKDQGLNGVVYFIFDFEKIITSFFYFPTNFYDQFLFAVRHRASVLFDLIQDDDQLKAERKKAKLEGREKYKGYSKDDMRLGGQTTFTFWGAPTTICGQKYSMQCNMLLRLRIRNFFILIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6P9</accession>
    <name>A0A183H6P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3162</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002031">
        <property type="protein sequence ID" value="VDO35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6P9"/>
    <dbReference type="STRING" id="387005.A0A183H6P9"/>
    <dbReference type="WBParaSite" id="OFLC_0000316001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000316001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000316001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000316001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14880" checksum="B13F292517B59415" modified="2016-09-07" version="1">MGHCCGSRSFEDWRDSIWWQKVNSIAELKQRPFDLAVPDFCCRSERLNCGRRDHPSNIYYNGCLDYLIKTMEEQLLIISGTAFAFAVVQLFGIGFAACLYTKRREFLEFRPVSSNSRQRDDATVMYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H750</accession>
    <name>A0A183H750_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3310</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002177">
        <property type="protein sequence ID" value="VDO36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H750"/>
    <dbReference type="STRING" id="387005.A0A183H750"/>
    <dbReference type="WBParaSite" id="OFLC_0000331101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000331101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000331101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019207">
        <property type="term" value="F:kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF2">
        <property type="entry name" value="GSKIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="3">
        <location>
            <begin position="50"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000331101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18546" checksum="59EAE31F7AFF4486" modified="2016-09-07" version="1">MDGFGRRRIESNSEDSSNDNNALTSAQTMDILNDIAERCANFGLGDSLLEKEALAAIREIGFAVRMISLPESLPRTSDLIFMNLITLEDRMYCIELTQRGWRVASDRHDSMNGDYRQLDLHTRYFETIYQLLNVVSPEFRNQFANKLSNKLTALSNGVAGSKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H760</accession>
    <name>A0A183H760_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyco_hydro_2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3323</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002190">
        <property type="protein sequence ID" value="VDO36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H760"/>
    <dbReference type="STRING" id="387005.A0A183H760"/>
    <dbReference type="WBParaSite" id="OFLC_0000332101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000332101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000332101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552408" evidence="2">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000332101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="24212" checksum="56417CF6CC66B12E" modified="2016-09-07" version="1">MFLLLLSALIPGVCTILQVQRNERRFYDQLDGLWTFVREERNSPSVGIKRDWHLYDLSEFENATVMPVPSAYNDLTADREVREHVGWVWYQRKFFVSVRDKYYRHFVRFSSVQYYAVVFINKKIVGIHVGGHLPFEIDITNHVLFDDENRLTVAVNNTLTSETIPPGEFRYIQKQHGGRKQYSDGFVILEKMFQENVKQRLSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7B8</accession>
    <name>A0A183H7B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-patch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002242">
        <property type="protein sequence ID" value="VDO36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7B8"/>
    <dbReference type="STRING" id="387005.A0A183H7B8"/>
    <dbReference type="WBParaSite" id="OFLC_0000337901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000337901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000337901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000337901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22214" checksum="E8DA33B64F11D95E" modified="2016-09-07" version="1">MTSRQEQRNAINSQNIAWKNVSDDSKFGKVMLEKMGWKSGRGLGKHEQGITENLQMKANILTRGLGCSERNDNVWLAHHDDFAAILADLNKKKEKSEAREIKKSLRKVKSKIILNEHRKDRYLPDLSVMSEKDKCAIFGKRLTPRTVSKSTEENMQQNEIKSESSFGNMIVKSVSINDYFAQKMLDLNKRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7M2</accession>
    <name>A0A183H7M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3485</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002333">
        <property type="protein sequence ID" value="VDO36676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7M2"/>
    <dbReference type="STRING" id="387005.A0A183H7M2"/>
    <dbReference type="WBParaSite" id="OFLC_0000348301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000348301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000348301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000348301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16755" checksum="DD90547112398AB4" modified="2016-09-07" version="1">MSLKRRLLKSISNALSRPELDFDFLLNDKNLNLIRENIRCRKGIGDIDAVHRLWKQIQDYSGKPKQSEQEYQFLWNKLYEEAMLIPNLCHTNVAKGNLSTTCPVRFFGEKQRDGNLETTETIVKAWKALYTPLNACGERSYAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8H2</accession>
    <name>A0A183H8H2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3784</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002642">
        <property type="protein sequence ID" value="VDO37732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8H2"/>
    <dbReference type="WBParaSite" id="OFLC_0000378301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000378301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000378301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000378301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45996" checksum="4E86AEF0D1822C10" modified="2016-09-07" version="1">MRELQQRSRYKIRRFSMHNESLFFLCAADDRWCRTYGVNSDGLHCTAFVRVYDYRRVSRQETRVLRIQYCLDHNFHSDEDATVDAPFTPEIFMHEVEERRLRTAGMVKSHAQRARLLRRRSEIGSEIMSENGGVWTEEGVREDDANLQELDAYASDVSKRTPQVRNDDSASVVEFAEGPDTEHDGQEDTVGGDGERNVDFGIEGSEEGVGQEEQVGENAASKLKRVVNLVEQCNRRVSESRSIRSIESREIQSGSGPGQPHYVTHRSNFSSYTLYNLVMQIELQCELFKERAQSLKHIVAAKKYLKYLTSLCDSIATDPDCSKPVEELAAEIFDLKEIVNSGIVVTKQTNLLPTLSFGSGDESNNSVQQRDGKSESETQPLIFLPIVPARSTPEELGEFFTDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8W1</accession>
    <name>A0A183H8W1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS3923</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01002793">
        <property type="protein sequence ID" value="VDO38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8W1"/>
    <dbReference type="STRING" id="387005.A0A183H8W1"/>
    <dbReference type="WBParaSite" id="OFLC_0000392201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000392201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000392201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="17">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDO38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000392201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55122" checksum="03C0114BCF391402" modified="2016-09-07" version="1">MTLEDVRFLERIVHCILLKIRFNYRSTYYMVEHGFYNFLNWFDDRAWYPLGRIVGGTVYPGLMVTSGAIHYILSVLNISVHIRDVCVFLAPTFSGLTAIATYFLTKELWTPGAGLFAACFIAISPGYTSRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSIFWATLTALSYFYMVSAWGGYVFIINLIPLHVLTLILIGRYCSKLYIAYTTFYILGQIMAMQIPFVGFQPVKTSEHMAAAGVFGLLQVIAALKYMQHRVSRKEFMTLFFGGISVVFILGISTIVILTYAGYIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHITAAVFPVGLWYCVKNVNDERVFVILYAVTAVYFAGVMVRLMLTLTPVVCILSGIAFSYTYEKYLIDEGDQSKSVNNEEENKHLYDKVGKGRKSGSWTNQAAPESSEVSIGMNARSIVSVVLILMLLMFVVHCTYVTSNAYSHPSVVLQSHNSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBK7</accession>
    <name>A0A183HBK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4869</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003911">
        <property type="protein sequence ID" value="VDO41303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBK7"/>
    <dbReference type="STRING" id="387005.A0A183HBK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000486801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000486801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000486801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000486801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34853" checksum="7D1080A42D02B06D" modified="2016-09-07" version="1">MPYDICDDEATLDVIESEMASRGITQAFIDDQRGAAEKQMLDEMKLLRQEGHPLDVRQSDGSTYLHIAAANGYYDVAAFLLRCGVSPSVRDNDLWMPVHAAACWAQPDLIELLCEYGDLCEDTTTRAIIVTVQQQEARKKRLAFGVRDSRRQSRKRKKFESPQQPTANTDNPFSARGAIRRLSLRDRSGMTLARLEAQKEQTDLLRSWSKEDVSYGNDDSISANNSATSGQGGPENTAHTLGQFEIRRRDSPAKKVIKPSSQKTKPMSPDEWLRKLDKENGCIEDDDESSLQLQRGGRTRSSQKKKKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBW4</accession>
    <name>A0A183HBW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4975</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004063">
        <property type="protein sequence ID" value="VDO41643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBW4"/>
    <dbReference type="STRING" id="387005.A0A183HBW4"/>
    <dbReference type="WBParaSite" id="OFLC_0000497501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000497501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000497501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000497501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12865" checksum="229FF6A783D67C79" modified="2016-09-07" version="1">MIRREGEEGKGSLDDEKVCNNIFLHVHAFHDGDREPVFPLGYKRTLGSSLRWRKMEEQRERAYKAVAYAAVTFSLISILSVCITMPIVYSFVDHIQQQTRKDLQFCKVSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBZ2</accession>
    <name>A0A183HBZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5005</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004094">
        <property type="protein sequence ID" value="VDO41747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBZ2"/>
    <dbReference type="STRING" id="387005.A0A183HBZ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000500301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000500301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000500301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000500301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54858" checksum="3270F1C4DC9B850C" modified="2016-09-07" version="1">MLFSLRNSRITRSHTDFYLKCRSPCINDAAVKTNSLIIRLDKLINQCPSDSSKRKAFERETVPWVIDRDAVRCRTCSMKFSLTRRRHHCRLCGEIICHACSKFLPFVDARKLTNPAFAAQLLEEINSSETNIPEEPLSHLSRSTSVAEAIKQAVSSESLQSVRLKSERLFSSTLSLVKRDGTEVSLASLLQQDENEHLRICTECKVLLDIRNEKMEMLASPPMLVVLYERLCTLFRDAQKLATSYARISESLSRGETMYSLDSAVRLRNRLTQLQREIDSVSSRVEIHRVTEENMFEHCTLREQIIRKNIRDFSLQMLQRLVVQMNLHPSEDHYNELQQKRRADIKHRIDMERKRNAFILTPSTSNRFSSHLSETEMVRQNSKSLLKESVSFSDIVGGCEDYGWTPSKILLHTNPFIEEEDKANPLQEQILIIKGYLKQAVEDSRLEEVEILERNLCDLEHEIEKLNKNNSSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE57</accession>
    <name>A0A183HE57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small subunit ribosomal protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5769</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005135">
        <property type="protein sequence ID" value="VDO44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE57"/>
    <dbReference type="STRING" id="387005.A0A183HE57"/>
    <dbReference type="WBParaSite" id="OFLC_0000576801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000576801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000576801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000576801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9498" checksum="44FF53C5A475EDD2" modified="2016-09-07" version="1">MPLARDLLYPDPQKERERCKLKRLVQQPNSFFMDVKCPGCYKITTVFSHAQSVVVCVGCNTVLCQPTGGKAHLTEGCSFRKKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEC8</accession>
    <name>A0A183HEC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005240">
        <property type="protein sequence ID" value="VDO44518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000583901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000583901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000583901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000583901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10491" checksum="81F4543E7CB9AC6F" modified="2016-09-07" version="1">MAQLEHTFNVYASFKQTNHTRLKCFVPQFLQSPALPNITASLRISAILRETSEGNSYQFVRLVLHPYTSDEDRFARQNRFRQILNIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEV3</accession>
    <name>A0A183HEV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SPT2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6015</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005481">
        <property type="protein sequence ID" value="VDO45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEV3"/>
    <dbReference type="STRING" id="387005.A0A183HEV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000601401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000601401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000601401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000601401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15842" checksum="80505818FE347A70" modified="2016-09-07" version="1">MMSREEAIIRFKTHERATFCKQILSIFRLRQLRDDDLDEDVDDEEYDSEMDDFIDDSEFDQHLKRGDLEETLRLINPRYDKNRWKLRERMIDDRYMEASYRDIAREEKRSSRIGLIEDIREARCGKSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFB6</accession>
    <name>A0A183HFB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005735">
        <property type="protein sequence ID" value="VDO45691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFB6"/>
    <dbReference type="STRING" id="387005.A0A183HFB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000617701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000617701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000617701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000617701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36749" checksum="661FD18D96084B21" modified="2016-09-07" version="1">MELDRTEDNIFWFRFSHHANYRELQQLFWIASESLNHDLISNILTECPYHLDSLLIMAELLRQQENYQLSRDLIERGLFCCESVFAPRFQLSNFDHRIDYSNFENRAFYLLLHRHLRNLVDRHCFKTALHVARLIYRLDPISDPLAIMLTIDTIALKAREYNYLILLYNTLQNSKNLDRLPNFAYSVALARFFLFCESGKAEDKEIADFMIASAIRHFPTVLLKLLDAMNVQPDPAIENNEHINALAHERENEGMKLLTSIYVKLASSIWLEDPSVLSWLEGVTTVTVSSFNNFKDELAEWKKLQVFHNIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFJ3</accession>
    <name>A0A183HFJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005836">
        <property type="protein sequence ID" value="VDO45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFJ3"/>
    <dbReference type="STRING" id="387005.A0A183HFJ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000625401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000625401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000625401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000625401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7173" checksum="5D6317D0CEA2E311" modified="2016-09-07" version="1">MGRTSRVVPKQWLRYEPVGLPIPNTRFLVFKTPLSMTLSTKLPKEKRFTTLNLLQKVSRSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFL8</accession>
    <name>A0A183HFL8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS6283</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005880">
        <property type="protein sequence ID" value="VDO46022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFL8"/>
    <dbReference type="STRING" id="387005.A0A183HFL8"/>
    <dbReference type="WBParaSite" id="OFLC_0000627901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000627901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000627901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO46022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000627901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27558" checksum="DCEA408B27EAF4E9" modified="2016-09-07" version="1">MTRLKKGEDKPIKKKQCKKDELRETWTRKADFLLSVIGFAVDLANIWRFPYLCFKNGGGAFLIPYTLMVLIAGVPLFYMELALGQYYRKGAVTTWGWICPLFKGIGYCVIMIAFYTDFFYNVIIAWALHFFLKSFTTHLPWASCGNDYNSAMCYEPSWNDDKDNECVQPLNKSGMGLISAAEEYFYKEFLGLHMPGAANSSVAHSLSNLGSLNWEMVFCLLLVYIICYFSLWKGIKMSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGA5</accession>
    <name>A0A183HGA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransf_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6516</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006232">
        <property type="protein sequence ID" value="VDO46792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGA5"/>
    <dbReference type="STRING" id="387005.A0A183HGA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000651601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000651601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000651601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF39">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO46792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000651601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16832" checksum="EA638C4D0A364F4F" modified="2016-09-07" version="1">MIASVEGSGWLHLKEMEQYTKSKIRSIFHCNCHAKPSISAPEILQNNFDIVVSIFCLEYCSKSEMEYKEAVRNVADQVKPGGLFVMGGVLEETWCSFGGRKFTCLYLTENLLFQALREANLLVDEQSNIYYCSNGIFLICCKKKTSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHB9</accession>
    <name>A0A183HHB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3480 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006817">
        <property type="protein sequence ID" value="VDO48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHB9"/>
    <dbReference type="STRING" id="387005.A0A183HHB9"/>
    <dbReference type="WBParaSite" id="OFLC_0000688001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000688001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000688001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022557">
        <property type="entry name" value="SARA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11979">
        <property type="entry name" value="SARA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01421">
        <property type="entry name" value="DUF3480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smad anchor for receptor activation-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000688001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27338" checksum="CA2C13B8389545E3" modified="2016-09-07" version="1">MPIILGSTLMVCDDTESILIIPTWALEEIIKLIKANKNMIAWGLDFSPDADSYLVCKQDDAGCFNSQIFTNGVENRKVTGASFIVIDGALKDGGEPFAVNVLEVSSFDIFSLINFFLEGMNGGNNDGELDGMAIRFRSDIMESLLEALSVGQDFEQISSAMKFSIKWNDDSYTQQFVGGLVSPIDNRSLIGCYQYGLKKSKILGSSYPIPNQVDWSLRLISVYNVAKGRFVQRVQSKVLNVSEQVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHL3</accession>
    <name>A0A183HHL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6977</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006982">
        <property type="protein sequence ID" value="VDO48707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHL3"/>
    <dbReference type="STRING" id="387005.A0A183HHL3"/>
    <dbReference type="WBParaSite" id="OFLC_0000697401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000697401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000697401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000697401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8745" checksum="D73D045312868FC4" modified="2016-09-07" version="1">MERDISMNNLDEAKPENENRQSDIESENAENTENASEIPNDPLVTLNEVIEAHEELEAEAEALLGGANANVCTYPEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHN5</accession>
    <name>A0A183HHN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6999</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007022">
        <property type="protein sequence ID" value="VDO48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHN5"/>
    <dbReference type="STRING" id="387005.A0A183HHN5"/>
    <dbReference type="WBParaSite" id="OFLC_0000699601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000699601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000699601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000699601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30249" checksum="E94B04E55009C8E7" modified="2016-09-07" version="1">MSFAGVGTRGYGDFTGLGNFNNFESTGDHQQPPHMTMDEGATPQPLSANGRRSGNSNYSLQQEIIWIKQDSAQIRNAVVLLEKEKDNLRQAVRKLKLENARVKQKIKRMQETINGLTGISAETDNLKVGATEADLDYDDIGRDFILVGGAQDPLSLRFEVSIRDERGIEHKSAERYYWYKMAEHFGDSETMAKILDAPSTIKAEEAMKDIKDFDEAKWNEVKMNVWETGQRLKLEQTRWIANLLVYTGKTYIAVASQDKVRFFSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIH6</accession>
    <name>A0A183HIH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007495">
        <property type="protein sequence ID" value="VDO50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIH6"/>
    <dbReference type="STRING" id="387005.A0A183HIH6"/>
    <dbReference type="WBParaSite" id="OFLC_0000728701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000728701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000728701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552550" evidence="1">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000728701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22241" checksum="62EF8D554309960F" modified="2016-09-07" version="1">MCIRFLRTIRNGLFSLFVSSSLQDVDALTKEEKKLLVKTWPNLKERTPDMFLRAWIKSAQMSVNIRKATGLREDEEPETNEKFISLSPLLENFVDKLIIEFRCNDAKVAEACRKLGARHLLIENFHMNFWDIFLGNLIRIIIDTHSERDQREIAAICEKFCSFFVSFMRDGYKKRLQEEISGRRSMNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ63</accession>
    <name>A0A183HJ63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007913">
        <property type="protein sequence ID" value="VDO51374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ63"/>
    <dbReference type="WBParaSite" id="OFLC_0000752401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000752401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000752401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000752401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11552" checksum="87EBB7A5ECACCDC9" modified="2016-09-07" version="1">MDRSSFEALQISLSAFPAGRINSGNNCIDQGILAVERCDWVCFYVEKTGAVGVVLRSTVIFRSLPWTDSDEFADFCIPTGIEKSFPLSPFHFQLFQVISAPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJI7</accession>
    <name>A0A183HJI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008129">
        <property type="protein sequence ID" value="VDO52043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJI7"/>
    <dbReference type="STRING" id="387005.A0A183HJI7"/>
    <dbReference type="WBParaSite" id="OFLC_0000764801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000764801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000764801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000764801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="5319" checksum="C4315DE07339F2D9" modified="2016-09-07" version="1">MRQWRHFDERCMTSNILEQYTAELPGRRRGYYKFSSHHPDFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKC0</accession>
    <name>A0A183HKC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4912 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008616">
        <property type="protein sequence ID" value="VDO53220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKC0"/>
    <dbReference type="WBParaSite" id="OFLC_0000793101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000793101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000793101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000793101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8158" checksum="0D34448C666B56D6" modified="2016-09-07" version="1">MLLFHDFRSLFRYLSLLFIIHHGKLKSRAAPVDGALIPSRVQDFRARYDHATDAIYIHWSYPDEVQREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKF8</accession>
    <name>A0A183HKF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7964</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008674">
        <property type="protein sequence ID" value="VDO53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKF8"/>
    <dbReference type="STRING" id="387005.A0A183HKF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000796901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000796901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000796901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000796901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18076" checksum="04F1757ED2247FB2" modified="2016-09-07" version="1">MVWFTPPLTSGEFPTLLYIAWIIAYCFHQIAIYSMFVSVMAFFAQVSDPAIGGTYMTLLNTLSNLGGNWPVTLILSLTDHFTFKNCISRETKTILGSCNTDVSAIQCTEKGNVCEVAVDGYYIAVALCSIVGIIWYKLMFRKIKYFQEIPRKDWRIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL61</accession>
    <name>A0A183HL61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MNNL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8221</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009126">
        <property type="protein sequence ID" value="VDO54631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL61"/>
    <dbReference type="STRING" id="387005.A0A183HL61"/>
    <dbReference type="WBParaSite" id="OFLC_0000822201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000822201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000822201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Notch ligand N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO54631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000822201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9205" checksum="CB8CCFB5FD1EC758" modified="2016-09-07" version="1">MGYNILRLCSCAGSFEIRLVSLTVDSKEEFPPELRICLKHFERRINYNGECTFGEVILDAERLRNGTKIEFQSGWPRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLF3</accession>
    <name>A0A183HLF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine-rich cell wall structural protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009295">
        <property type="protein sequence ID" value="VDO55083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLF3"/>
    <dbReference type="STRING" id="387005.A0A183HLF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000831401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000831401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000831401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000831401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="10883" checksum="84ACDF7ACDC18584" modified="2016-09-07" version="1">MLACCMDPERDRSGEHHIKCYKFKGDQIGDIIGGFISGGGGSGSSGSRGGGGGVNVGDIAGIIGGLAGPGSKGDKIGGLISGIGGLIGKKGQYRDGDQFRVTILRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLX9</accession>
    <name>A0A183HLX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1284 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009645">
        <property type="protein sequence ID" value="VDO55920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLX9"/>
    <dbReference type="STRING" id="387005.A0A183HLX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000849001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000849001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000849001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000849001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25213" checksum="1D42C689BFCDB459" modified="2016-09-07" version="1">MLIFFDNGIDSFVHERTVYILAEQKYRFHNFKEEIDRCSNWCLVPQCRQKFVKHYLKNFPDWPLVPMKRKENTQRVNILREGKPHSAYVLRTERQFALLRFPIRSKYGADCVMTPCNRHCHIDEWIYRGSERLEAIRQTIDRLEKIEQLEKTGVSTAPIRSRREARLAHNLEYTLPLPRQIILNMNLSKEVDLCPRGQALLSDNEPVIDINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM44</accession>
    <name>A0A183HM44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8556</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009786">
        <property type="protein sequence ID" value="VDO56235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM44"/>
    <dbReference type="WBParaSite" id="OFLC_0000855501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000855501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000855501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000855501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13784" checksum="64862D169AD15314" modified="2016-09-07" version="1">MNRNTGEAYSDIQCSSHDESIAFDCSSPDAQNTVYCLLGSTEVDSKDVRNIEAVRQLCGSRRRSIVFCRACGLFRFGRWLTPKEKRTKLWVANLFHWQHTTGTLNEKKNWLFYKLSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMF0</accession>
    <name>A0A183HMF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDEase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8665</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009989">
        <property type="protein sequence ID" value="VDO56807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMF0"/>
    <dbReference type="STRING" id="387005.A0A183HMF0"/>
    <dbReference type="WBParaSite" id="OFLC_0000866101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000866101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000866101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO56807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000866101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20353" checksum="E6C053F8B325D90D" modified="2016-09-07" version="1">MPFFGKQIEFYSYWKQPEHEGCESTSRDNEHYSQPQTSSAPATDTSILIDKKQKEDSLLIRTSKNNRNTQSDEVDANVVACSSLEQTSGFVILLSDGTTYSCEELNSNDELVRIAEWDFPIFHFAEQHPTTILSRIAYSVFREHGLFQIFKLSSNKFFNFFHSLECGYWDIPCKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN17</accession>
    <name>A0A183HN17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8881</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010410">
        <property type="protein sequence ID" value="VDO57845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN17"/>
    <dbReference type="STRING" id="387005.A0A183HN17"/>
    <dbReference type="WBParaSite" id="OFLC_0000887801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000887801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000887801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF42">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO57845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000887801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21498" checksum="527B464A43E157C3" modified="2016-09-07" version="1">MSAELSYKDLKALLDENDIDLSMRQLVSIPSKIPRATHLDFSNNLITSIPADFCLLTHITKLDLSNNQIVHLPEEFGKLINLIHLDLYRNEIEELPLSFGELASLKWLDLKDNPLELELSQAAGDCLDEKGCKMAALNVVQLMHDRSVRQQRLLEKQKSVKKRMSIFLFEISVLYILAYRYKIKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HND4</accession>
    <name>A0A183HND4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8994</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010618">
        <property type="protein sequence ID" value="VDO58310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HND4"/>
    <dbReference type="STRING" id="387005.A0A183HND4"/>
    <dbReference type="WBParaSite" id="OFLC_0000899501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000899501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000899501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO58310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000899501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11579" checksum="B2F292846B8746C3" modified="2016-09-07" version="1">HDHGPKIPSYTLYDNYREIPKLRAHEERLARIGLKDPWIRNHAYLFMGRFAGDPWGSFKYMIRAGWKLGCGVAATVIAIEESYMYYKYGHTHWGKEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNK5</accession>
    <name>A0A183HNK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010760">
        <property type="protein sequence ID" value="VDO58587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNK5"/>
    <dbReference type="STRING" id="387005.A0A183HNK5"/>
    <dbReference type="WBParaSite" id="OFLC_0000906601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000906601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000906601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000906601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8877" checksum="FF1C6F475397D4AA" modified="2016-09-07" version="1">MSGNKVWLMDDRHLKSFWSYHQAALRWLEAHRAAREYAINSSSDMISSPIDMKTNFNRAHFAKRNHLPNTGVFLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPP7</accession>
    <name>A0A183HPP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011611">
        <property type="protein sequence ID" value="VDO60789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPP7"/>
    <dbReference type="STRING" id="387005.A0A183HPP7"/>
    <dbReference type="WBParaSite" id="OFLC_0000945801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000945801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000945801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000945801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11832" checksum="56ABCDD1B518BFDD" modified="2016-09-07" version="1">MFIYLELFDFQTLNTQIQIENDEDANDIINASVNQTLEQEEQSGHHEEWDKANSSFTPVYDETSGVEVVDSEPNPIRDSHHAGLLPHSPCSVRAYETILEVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPZ0</accession>
    <name>A0A183HPZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011835">
        <property type="protein sequence ID" value="VDO61409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000955101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000955101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000955101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000955101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12277" checksum="E63663B121DCED25" modified="2016-09-07" version="1">MIITLALEIGSLMWVSVTFCACCRREFWIFFLPLLAFLATLTLAIALFIYTDNNKSAFDILNESREGALAAYQINFFYSYYIAWAALFMIIICILIGAFAKKLAEICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ31</accession>
    <name>A0A183HQ31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NSFL1 cofactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011921">
        <property type="protein sequence ID" value="VDO61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ31"/>
    <dbReference type="STRING" id="387005.A0A183HQ31"/>
    <dbReference type="WBParaSite" id="OFLC_0000959201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000959201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000959201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000959201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15442" checksum="3E2D1A0C357299C5" modified="2016-09-07" version="1">MERGFICCQTLVPGGGEERETNVVNCFRSRIATLHSSDKKPRSRSSSPPNNDEKRQQGFFVGGSEQSGNLVLGPDSSRNEDIVSQFFNSARAHGAESLTPEENAKFGTRDAVKFASGSKGYRLGDTVQPSELVESNVSSDSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQI2</accession>
    <name>A0A183HQI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved oligomeric Golgi complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012282">
        <property type="protein sequence ID" value="VDO62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQI2"/>
    <dbReference type="STRING" id="387005.A0A183HQI2"/>
    <dbReference type="WBParaSite" id="OFLC_0000974301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000974301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000974301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 4 N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000974301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22458" checksum="91689D06AD5FD969" modified="2016-09-07" version="1">MIVKVKEEETLIRSLDEILINDLRKTSVNEERLANSDISLPFNLTVTRLKNQMTLVESDTKQLASKLKMISGLADNISSKVLALDIAKGRVVECLQRVSDLMDLRNCADGVRSAIEQEDYELAARHIHKFLTLDTTVFQMGDHGDGKDMGQSMGKSYEILREALTEMKSVIEKRFDQVTSIFISYIFRSLISHIYANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQZ5</accession>
    <name>A0A183HQZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9903</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012647">
        <property type="protein sequence ID" value="VDO64318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQZ5"/>
    <dbReference type="STRING" id="387005.A0A183HQZ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000990601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000990601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000990601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000990601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4790" checksum="5A6C11C43FC4B953" modified="2016-09-07" version="1">MIYAGTFQHANFTSPINLESCPTKTCQTQRAKTDPHLRHLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRI3</accession>
    <name>A0A183HRI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10098</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013113">
        <property type="protein sequence ID" value="VDO65803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRI3"/>
    <dbReference type="WBParaSite" id="OFLC_0001009401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001009401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001009401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001009401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20453" checksum="058186DA943A4A08" modified="2016-09-07" version="1">MITTFSLSTIGDLRQERAKIQRNLLTQENTSETEKTSETSKSSREFFEIEQFHLKLEAIAQQQESETSETSTDKDQDSRKYEAGASSTSNSETVDNSRKFDKFETLEEKTEHAKRIISAAFNYAEQVRHQIEQRSRLANDDERRNEDFKDTAKKPDHPLKQTLEPEKSIESDEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRI8</accession>
    <name>A0A183HRI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013120">
        <property type="protein sequence ID" value="VDO65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRI8"/>
    <dbReference type="STRING" id="387005.A0A183HRI8"/>
    <dbReference type="WBParaSite" id="OFLC_0001009901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001009901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001009901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001009901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23101" checksum="822E3F4BA4E49643" modified="2016-09-07" version="1">MIDELSVLLRNPRITARLNYDERDLLMEQIFTCGQFGFVELSSLHLFASILSWQNPTLGCFMNDKRDNIFGGMNILHSTDGLDSDSCSAYSSTVAAGALVVFLRFLLDRGPWPEYYLTDQPVVVYSIAAEEKFRQFSYGRWVRDSFISSVHHVRPPEIGWSPDLFAYFLLLSIMFGGFIVSHFCYKPKVKQFYHFSYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRS1</accession>
    <name>A0A183HRS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10185</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013309">
        <property type="protein sequence ID" value="VDO66508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRS1"/>
    <dbReference type="STRING" id="387005.A0A183HRS1"/>
    <dbReference type="WBParaSite" id="OFLC_0001018201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001018201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001018201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO66508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001018201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11224" checksum="287BB3EA794754BE" modified="2016-09-07" version="1">MLKGAFWKNQASIPFRFTIIRANDQCASCSEPTMTRPFYAFTCRHFFHKDCLESEMKQEQDKYNSLVEKERILQKQLEKSTSLNWTPKKISGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS36</accession>
    <name>A0A183HS36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10294</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013556">
        <property type="protein sequence ID" value="VDO67364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS36"/>
    <dbReference type="WBParaSite" id="OFLC_0001029701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001029701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001029701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001029701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15403" checksum="DD89D090B498588C" modified="2016-09-07" version="1">MKVRIDKVKRDFLQFAVNYNVGESLWQSGMFLTEQPKTPLTVSQNVTVESIITNSKECAYKSSSNDGMENDSELQMAEYYSEGTAEEKKPETENDLSTINSMYFLSEQELVNSEYIPEKSDSQYMLSDLDMLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSB3</accession>
    <name>A0A183HSB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS10377</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013768">
        <property type="protein sequence ID" value="VDO68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSB3"/>
    <dbReference type="STRING" id="387005.A0A183HSB3"/>
    <dbReference type="WBParaSite" id="OFLC_0001037401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001037401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001037401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF455">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN PGP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001037401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18335" checksum="F4475A15F67C163B" modified="2016-09-07" version="1">MAGFFYHLQSNVLSSLNKEIMKQDTRQNTIFYLILGIISSFSTFASGSLFGMVGARISMRLRIAVFKNILRQDMSFFDSKCHSTGELTERLANDAEDVRAAIDERLASAMQGIISLSAAILVAFLFDWRMAGIGVAICAILIIMQIIILQYLKIIDQKNIKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSH3</accession>
    <name>A0A183HSH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10437</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013904">
        <property type="protein sequence ID" value="VDO68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSH3"/>
    <dbReference type="STRING" id="387005.A0A183HSH3"/>
    <dbReference type="WBParaSite" id="OFLC_0001043401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11904" checksum="946352736FDD6BC0" modified="2016-09-07" version="1">MIRENFKINRNIAYQGKINVRNEERKEFLANCPIQYDSIMELIDRLDFADQPNYGDIYKLLDQRMQVREEHSVLMDAQYDWEEEETPSQEQLGNEEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSM6</accession>
    <name>A0A183HSM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014018">
        <property type="protein sequence ID" value="VDO68864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSM6"/>
    <dbReference type="WBParaSite" id="OFLC_0001048701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001048701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001048701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO68864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001048701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19013" checksum="692A287905E67CE4" modified="2016-09-07" version="1">FYRIAEFLPNFQSNVAVIAAYAYFFFTGVSVIVYVFEMIDVCLTLKNDFENVFNARLAKSLVLAAEEVPLPILLNVLFTYEPRISIASPAYLASWIKLIALTWGIVKFTKLRFFWCCLPLNPKHETRENFRRCFTCTLYRITMIFVNICHIIAIVIVIHNIVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT55</accession>
    <name>A0A183HT55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COX2_TM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014448">
        <property type="protein sequence ID" value="VDO70378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT55"/>
    <dbReference type="WBParaSite" id="OFLC_0001066701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001066701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001066701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001066701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="5988" checksum="FB2674FEA1096452" modified="2016-09-07" version="1">MRPETRVSHEMVSAAYCGVQILYFHGIVLFMVVVVVLLVVIYPIVISVALNGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTG8</accession>
    <name>A0A183HTG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014778">
        <property type="protein sequence ID" value="VDO71297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTG8"/>
    <dbReference type="WBParaSite" id="OFLC_0001078001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001078001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001078001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001078001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13198" checksum="4DA980290DF30023" modified="2016-09-07" version="1">MRDGLNTPCTLLGQTMSPPGVFMPCPAVPSPAPPVRRRILPLATRLLVYSNQLHHFGSKLEEMISRNPHLYHYYYYYSISFFPTLLPVDATCYAHIRLLLTPRLQVNCHVSVPLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTS2</accession>
    <name>A0A183HTS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015027">
        <property type="protein sequence ID" value="VDO72102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTS2"/>
    <dbReference type="STRING" id="387005.A0A183HTS2"/>
    <dbReference type="WBParaSite" id="OFLC_0001088401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001088401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001088401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001088401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7766" checksum="2ADA82F83C2227B0" modified="2016-09-07" version="1">MFKVACRFFDSTNKRTDEEYAESMYGIMNLYYNYTGQKKTFCINPEVCKDSAYEALGDPLGWPWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUR4</accession>
    <name>A0A183HUR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11229</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015951">
        <property type="protein sequence ID" value="VDO74882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUR4"/>
    <dbReference type="STRING" id="387005.A0A183HUR4"/>
    <dbReference type="WBParaSite" id="OFLC_0001122601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001122601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001122601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001122601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6412" checksum="994F6F2F7B569E3B" modified="2016-09-07" version="1">MDDRGKFIYITSDELQAVAKFINQRGRVSKAELIEYSNKLIVLESQSAEHVPEVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVF6</accession>
    <name>A0A183HVF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016577">
        <property type="protein sequence ID" value="VDO76700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVF6"/>
    <dbReference type="STRING" id="387005.A0A183HVF6"/>
    <dbReference type="WBParaSite" id="OFLC_0001146801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001146801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001146801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001146801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15787" checksum="2F0DF8D0E9F2B0FB" modified="2016-09-07" version="1">MDRWLLRGKLWADWTYRGINLGLYEFSTDLARSDWRLIHKHEEAEFMKCENPMKPIEYPKTMPLPPYLRAVCENGDVVGMEEKRINLDLCLDPQFNMIKHLFKQVYLNLSHNFFFFHSVCIYPFRLYIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVL2</accession>
    <name>A0A183HVL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH_44 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11526</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016722">
        <property type="protein sequence ID" value="VDO77094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVL2"/>
    <dbReference type="STRING" id="387005.A0A183HVL2"/>
    <dbReference type="WBParaSite" id="OFLC_0001152401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001152401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001152401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix DNA-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001152401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="32110" checksum="F30926972F28F746" modified="2016-09-07" version="1">MFAVFGFASDHILQVPFIAFYRKEYVESCLVINDLWKVYQWDEKWCHLQQRKKRLLELMKRMLNYQMENDNAAGMRIVTEQDMNEVHGVQTVEGLMDVSTKFQLYYGPEVPKMIDWEKIQNLSEDDPEREAAEMRFRAATRTDKYMACFSIFFCILEEKVDLCIQNGLSGMASRFGLTPLQFAENLDWKRHDIVQEDEEPLKAAEQYVCQSFPTSEAVLAGAIHVVAKQLSREPKVRELLRLRYRLRLKISVCPTKKGREEIDENHKLWPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVY7</accession>
    <name>A0A183HVY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11646</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017081">
        <property type="protein sequence ID" value="VDO78114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVY7"/>
    <dbReference type="STRING" id="387005.A0A183HVY7"/>
    <dbReference type="WBParaSite" id="OFLC_0001164901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001164901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001164901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001164901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21193" checksum="DA5CBE4E63ED0794" modified="2016-09-07" version="1">MQQCYYTFFIAEQWSLLLFKACCSSLHQCHKQTNLRHELLPYDVDVIEIAPGCFETGMTNIETSMKMYDTVWYRASQKLRDEFGHDYNDKAKKCLKEIQSKLVATETTWVIDAYYEAIVAKRPKLLYRIGWDALFMFHPYSLLPLRVQLYIMKFIMNLCGAPSPIITTKYACSGNPERKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWN4</accession>
    <name>A0A183HWN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11900</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017802">
        <property type="protein sequence ID" value="VDO80230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWN4"/>
    <dbReference type="WBParaSite" id="OFLC_0001189601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001189601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001189601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001189601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30958" checksum="D1567E367ADCEAA8" modified="2016-09-07" version="1">MSEQYKDHFQGFYRAIDLASTEGSSSNKLPKIYPSWSRVRKSYFRQNRLGRIDRAKSLSVDGSLRHGQRHPDEMNGPVLYTYGEDADGQYVVFESEEIPEGYEPVPVEELEAAAEGVELDDNWTVSAKEENLKSDLHGMWKPHQVESNELERKRLHETIENEQEAEELHLLSTPGEGPSMKKARMKNDDTEEPRESIETAGESINENSSLVHEYVHNKPLLDLADYTTKEERRRISQNLIDEIRSSANFKRIKPARSSTSELDEECNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX46</accession>
    <name>A0A183HX46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018228">
        <property type="protein sequence ID" value="VDO81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX46"/>
    <dbReference type="STRING" id="387005.A0A183HX46"/>
    <dbReference type="WBParaSite" id="OFLC_0001205801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001205801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001205801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001205801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9853" checksum="CD44D1F5BD5A2F16" modified="2016-09-07" version="1">MKRTADPDVHCTALLLTYRGKRRPLAHYQWVSWPDKFVPNQLTVPFTLLSSARARKTPTVIHCSAGIGRTGTLVVLEILSRQVYISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXT0</accession>
    <name>A0A183HXT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12293</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018905">
        <property type="protein sequence ID" value="VDO83590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXT0"/>
    <dbReference type="WBParaSite" id="OFLC_0001229301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001229301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001229301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001229301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="6946" checksum="53A0F0D41E36A726" modified="2016-09-07" version="1">MDENPTEADSGATPVATDSQAVTDSDGTVDAAAEIEGTPGPVKAGNDEKLPATTIAIITFTYFAILFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYY5</accession>
    <name>A0A183HYY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039908">
        <property type="protein sequence ID" value="VDP11942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYY5"/>
    <dbReference type="WBParaSite" id="OFLC_0001269801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001269801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001269801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001269801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="697" mass="80530" checksum="E743C77F8E76BF2A" modified="2016-09-07" version="1">MLFSFTAIKISAQCDLESDHTKLGRCLRPWLDLWEMIRVKEIHAANLVYPVPFYTRESVLFLCSAYFDSQSTCMTSEILEKCKRNEMIIFIQRHMRYYCGDRAKIVFGKFDCLRSALMSNQHCWRHIQDISSPTYRPSKCIGIPKFVNCMLPDVRSKCKNSGAHVFVDAITSFECALEKELVQQSAKYIARINATGEFTEKVGRSMLYHLLCYNMTLNPIRSNYYAEISQRSIGWVYHEYILNELPAALPVLDEEGNGQWYENICLFYDKFWKMTDEIFDGEISRPSIQKYLTVENNIANFFSTPPASFPTNGGQRSLNANKTFERSNEINSTDGLFSSSDSKTKQTFHYRRASARKINPNLDYVEETTLLESDPAIELALNNDENVLSISKTKSLKCTMKQEEEIAQCYAPMIELWNKIQNRHRSSDNILLPIFNYHLKELSDLCDLLDAIFDSCFTTSLINDCQGNSISYNLSFSADMKATITEKMKNDVSSEKQKMNPSIESEIHPVKILDGELFSYQLSTKCTEEMQMKTRMCVHPLLISWNNLRQQKPMLKNVSFPMYKYTSQELLELCDGYANVFQCAGSELITICLNEEMVRFTRDHFGYICTTQNIKRFMKHYECIVEVATAYSKKCQMFITGVAGPGKDLKKCRGIRQYYNCMKPEIIRECRSEALKEFETSIIEYGCDLSLHDSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ09</accession>
    <name>A0A183HZ09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12721</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039913">
        <property type="protein sequence ID" value="VDP11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ09"/>
    <dbReference type="STRING" id="387005.A0A183HZ09"/>
    <dbReference type="WBParaSite" id="OFLC_0001272201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001272201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001272201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Liprin-alpha CC2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001272201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15253" checksum="73DD9D3DC92ADED4" modified="2016-09-07" version="1">MSAQREATCLRDLNDKLEHRLANKDAAVRLNEEKVRSLQERLELAEKQLAQSLKKAESLPSVEAELQQRMEALTAAEQKQLSAEEQMNRLARQVEERSAELERAVQREKMNEEHNQRLSSTVDKLLSESNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ60</accession>
    <name>A0A183HZ60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypsin Inhibitor like cysteine rich domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12772</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039928">
        <property type="protein sequence ID" value="VDP12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ60"/>
    <dbReference type="STRING" id="387005.A0A183HZ60"/>
    <dbReference type="WBParaSite" id="OFLC_0001277301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001277301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001277301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="458"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="581"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="4">
        <location>
            <begin position="667"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001277301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="787" mass="86663" checksum="B787571120F73387" modified="2016-09-07" version="1">MITWSDDFLIRSRRKFTDSDLEFNRTGVETGICEAQGTCINCDNDSFSYYKCSVPHDCFTNEICTKQGFCCPTNKTLSSLSNDDFAVQCRTGTEECWCVSPFGGIIGSLKPKTADSNAACEALRLTLKHQFLATPHSLLLNSAPVKAECTENEQFAECVDECQPACFSRTSITCFSGRCKSGCQCKPGFIRQRNDLHAPCIPRNQCPLRITESERHCIDPLREYKTCGPACPISCSSENEKCRTERCVEGCFCKVPYILENGIDPLRSRCILSIYCPPLARDNSSINSTIHLTAMAPMTPKFHLFPEHREDSTNQSTATQCSDPLKNFQICGSGCPGGCNNQIAGFCGTQCVAGCFCRNPYILQDAYNLNSQCVLPHQCQSSIIQHQQICSDPRKEWTSCFSYECVRSCSNPKATCTTDDCTPGCMCREPYLLYDSNNANSRCVLPSECGSQCSDSLKEYQACASSCPMGCNNRIPQTCSPCVSGCFCKSGFVFEDAVNWRTSKCISLNQCPMTNISAFLVAFIPENNKLANITECPATTADLSGKFCNFDSDCPAQQRCCHSTLFAMTSSKQSRCTCIDPHAYWDPCGALCPEYCGQLATPVCSSTCNPGCHCAYGYVKARNHVNAPCVPRTQCFQPEYQKHTNKPYSMWKEIATVKMLSDGNKIIGDVRIKEISKERIKLEGTVKGLPIGEHALIIHQAGDLSDSCANIGPIMASDKKFNVSAIFGNVKADGIKNATIDREIDWPQDISLIGRSLVIHKLSVMEWSLRNEDVLPLACGTIGFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZA3</accession>
    <name>A0A183HZA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12815</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039944">
        <property type="protein sequence ID" value="VDP12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZA3"/>
    <dbReference type="WBParaSite" id="OFLC_0001281601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001281601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001281601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552689" evidence="2">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001281601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25187" checksum="4DA9BC1E2CFE8E45" modified="2016-09-07" version="1">MRILISILITLIGGTNALSFLTGEWTESMKQFFHETQQKIDEKSNQFLNELGKKLDSAQNFVEQSKDIFSTVAKNLKNGGEKLKDTVMKTAEKTLRGAGDEVEGFFSEVPNRVNDGFDEILTKLGEACSWILRNIIAPILFIIILFSLIYIFIISGCCGCCCSTLLSHFGLTLGNTFKQLKKGEQLRRGDRIIVLRDLETSIPLQGNESLNNRQILKDIHILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZP5</accession>
    <name>A0A183HZP5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12957</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via cytoplasmic region) with ILK.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039991">
        <property type="protein sequence ID" value="VDP12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZP5"/>
    <dbReference type="STRING" id="387005.A0A183HZP5"/>
    <dbReference type="WBParaSite" id="OFLC_0001295801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001295801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001295801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001295801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24591" checksum="74BA1AC183B03593" modified="2016-09-07" version="1">MVIRFTSNVTNPPVMLYMGVDKFENENLIRWGWPEDIWFHVDKVSSAHVYARLPSGQTIDDMPETLVEDCAQLVKANSIQGNKMNNIDVVYTPWENLKKAGNMDIGQIGFKDEKKVKKIRVAKRINDIVNRLNKTEVRLDIDYRVEREERDAKERQIKKEKQRELKEAEKAEMERREIEREMRSYDNVFNEEKMHSNYDGGNDSDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZQ6</accession>
    <name>A0A183HZQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microtubule-associated protein Jupiter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12968</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039994">
        <property type="protein sequence ID" value="VDP12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZQ6"/>
    <dbReference type="STRING" id="387005.A0A183HZQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001296901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001296901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001296901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001296901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12403" checksum="186B78D85F1CB714" modified="2016-09-07" version="1">AIYVNRSGIRFGSAPNFPVPSNGSVASRISEFEKKPGAPNLRVAGALNGPERQPNEASPIRSPLGPMSPRSSVYRTKPVIHADISGTPLRVIQPSSSMESVFEFPQSKQFIEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I060</accession>
    <name>A0A183I060_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13122</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040054">
        <property type="protein sequence ID" value="VDP12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I060"/>
    <dbReference type="STRING" id="387005.A0A183I060"/>
    <dbReference type="WBParaSite" id="OFLC_0001312301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001312301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001312301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="5">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001312301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33661" checksum="D41FDAD8B0980EC3" modified="2016-09-07" version="1">MSNIVRQSKFRHVFCKPVKHEQCMSDIRITEITWDSLFCACNSKFIAIICKGAGGPFLVIPINKVGRIEKDYPFVDAHRAPCLEIAWSPFNDNVIASCSEDTTCKVWLIPQNGLIRTINEPAVELCGHQKRVNTLAWHPTASNILLTAGGENKLLIWNVGTGDALLEISGHPDMIWSVSFNYDGSRFVTTSKDRKIRVIDSHTGEVLYQGNGHEGVKPQRAIFLKDGRIFTTGFTKRSERLYALRTQENLDEPLIQEELDTSNGVLFPLYDEDSGLVYLAGKVSGSKRCPFSFSLFLFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I077</accession>
    <name>A0A183I077_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13139</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040059">
        <property type="protein sequence ID" value="VDP13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I077"/>
    <dbReference type="STRING" id="387005.A0A183I077"/>
    <dbReference type="WBParaSite" id="OFLC_0001314001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001314001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001314001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF21">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552712" evidence="3">
        <location>
            <begin position="20"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001314001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="780" mass="88899" checksum="CF20AD5D1ED9EC94" modified="2016-09-07" version="1">MHILSSLITVFALLACCIGTQHKTRLAFCDQAPNSAFQIVCSQLKKWDSDARQHHSTSLNESWSLGSSQRIWSTGRSQWTNKFQSSTAWTTWTTWTAWSPWTLSHNLPSQGVPRNSHDKSALITNHHVDLPTLVRNFTVGTDTSKKPKRVILEIQHEFSSLPSKYYFLKKCKRQIKPIRVRGEQVMNVKTHFPHAVSSLLSSPKFAGQEQTSMTNQGFRKIINGVQRPPWTGTTKKDLYTMEQDTVGPPGQQLPNNLIRKQFSLASQPSMISSKQPSLIRMSDRSVESSAFSAEVDDNRLFKRNQSNMVTSSPLTSVLNGRLKALECMDLNCLCPFFHGSLTNLGCFSSSNGKEFSMAIRKEYRQLSADERQRFHSALNRLKRSGDYDKIAEWHSNPELSGGAHSGPAFLPWHREYLKRLEIALRLIDPDVSLPYWDSTLENMIPENTDTVLFSEELMGENDRNGNIINGFISHWITPKGRHIIRRFNQEGRPLNEDDIQAVMRHWDVIGVLAYTAPQPGCKYPTDWTSLEYSHANVLVWVGDDMFHQTTSANDPLFFLHHAFVDSIWEYWRQYRQSRDTRSRSYPPDLPECSGENHFAQNPMRPFEPLRNIDGISNNYNEKLYQYAPRPACARGQDEECESEFLFCDLSHGDARCSTKIRLGGKCDGYTHQENPCYNGYCLSGICIKGASTGRTSAKRARSLEEITVEPTTTLITTMTKTDIKKEQCYNSHECCSVWASKGECKTNEEIMLKWCSVSCHICTPQYDTTSGKFFGSIYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1H7</accession>
    <name>A0A183I1H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13589</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040280">
        <property type="protein sequence ID" value="VDP14150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1H7"/>
    <dbReference type="STRING" id="387005.A0A183I1H7"/>
    <dbReference type="WBParaSite" id="OFLC_0001359001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001359001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001359001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="744"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP14150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001359001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="996" mass="115061" checksum="193D9ADE72BC164A" modified="2016-09-07" version="1">MGRFVFKLNFRQICEAIAKVEEKGHKMIKDEHFASNEIQEVLDELSSLVLSVKQLINERSQKLQDSLRSQQYYAEANEAEQWMRERIPLVTNSDMGKDQAAAEGHLRRLKTLENDMNKFCDEIERLRKEAEVMLAAKHFDSTNIISSNLLEGLSNLLSSKQSKLEGLYKQLRDDIARRKIQLVDSARYHAFVRQIDGLDRWLSEKLEITKQENYERYEVCSSTDPIPGRDLAECQKLVTEFDQVVRELASAGERIAAVRRTQEELLRSGHPFAVSIKAKGTDLQHLWSRVNEVANERQQALQGAIQVHKFDQDADETLGWLEEKEAHQVALEDEDISRADLTALKQLMNKYDEFMRGVAAVEKQVNDLSREAERLMSLYPDTQEHLVVRKMGMEEQLKDVINTSNKYYEKLQQMRNLQSYFQEHRDLITFCSETLPNDVEGCKALMLRHAEYQAEISGRQPVVDEFIRKGNSMIAAHHVLSSEISGKIKQLESAMDLLKDIWKERLVLYEENLDLQQWKRDAHITDSWLTEKEDMLKEDWRKVENVDDADNKIRNFDDFLITLEAQGEKFDSLKRLTLLEKAYSKQCKKESERIRAEKEKNESRKESIKTFEKQNKLQDRRKERERRMTQEVSLMKPSPSYTEEVCASHTLPHPRRGTEPVPRIRTSSFESKEAPIIPSRQTNLSVSDGSSIEAEGMPKTSGSMLSVDETVMIQRIGSTRRTPKFTTRRSNSLKKVRTREDFGPIDMHGYLDRKQDLQSGAKKATIRTWKRYYTILCGQLLCFFKDEDSFLENSASAAPVNILSAECDACPEYMKKKNTFRLKIQDGSEYLFACSDDEKMLEWVLKIRFHANLTPAQQLRSFNKSIAQKFSGNYLYLQMHIETRQKEINESPPMYSPPPRPGETLRRHTTELVSSVQANALSSLPYEPRLYEKPGITTSSESEMILEAQNQPYKSIATTASSVQHENGFRNVVGIDFLNLKGYDKELSVNSGKIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I203</accession>
    <name>A0A183I203_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calsequestrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13765</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040382">
        <property type="protein sequence ID" value="VDP14600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I203"/>
    <dbReference type="WBParaSite" id="OFLC_0001376601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001376601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001376601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001376601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14669" checksum="77D9974D6A962702" modified="2016-09-07" version="1">MSEKYAGTTRVRVIPVSYDAFDAIEPLKQLVEDHGSSFQARFIESTNPSKSSGELKSLSDGIVIDKNIFKQSIGALNITSDNLIVLYLFVLCVTICAMKKKKKLMINSGKFNNKTTPSGHWTLHITVINHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I266</accession>
    <name>A0A183I266_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RICTOR_V domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13828</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040418">
        <property type="protein sequence ID" value="VDP14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I266"/>
    <dbReference type="STRING" id="387005.A0A183I266"/>
    <dbReference type="WBParaSite" id="OFLC_0001382901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001382901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001382901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001382901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16325" checksum="C29F914DEE4728CF" modified="2016-09-07" version="1">MSRDDIELNIASARLLLNLIPGLDSVVLSEPEGLIPQLYRWAESDATNCYLRAYSFGLLAAALDVTSVASSLKIENSALIPIALRRLKHLFERMEKEKQETTEASEPDKENKEEDVEDNGPFAGIPRETFHNGERPLLADVSCTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2I2</accession>
    <name>A0A183I2I2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13944</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040489">
        <property type="protein sequence ID" value="VDP15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2I2"/>
    <dbReference type="STRING" id="387005.A0A183I2I2"/>
    <dbReference type="WBParaSite" id="OFLC_0001394501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001394501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001394501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001394501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8336" checksum="8F4872669D16330E" modified="2016-09-07" version="1">MEALPEDFIDYNRLKIIFAILEYEYGVVQSSEETLSSAAPTENTNKRNIPEWMKTWHSMQNKKKKKSSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2L3</accession>
    <name>A0A183I2L3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13976</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040510">
        <property type="protein sequence ID" value="VDP15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2L3"/>
    <dbReference type="STRING" id="387005.A0A183I2L3"/>
    <dbReference type="WBParaSite" id="OFLC_0001397601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001397601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001397601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552741" description="Large ribosomal subunit protein eL13" evidence="7">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001397601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20423" checksum="89DDE31C14F4AC95" modified="2016-09-07" version="1">MVCRVAIAALVLGFSRVGQGCFSSRNGFVWIPGLRHVRGFVDWQTRVRTWFNQPARKERRRRNRYKKGRLIAPRPVAGLLRPAVRCPSIRYNKKVRLGRGLNLQADELKLATQLRGVVLPIKQVVRREKAREVTEEEKKFKVYCHLRRLRADKRLKGTRDKKAREVAEEGIGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2R4</accession>
    <name>A0A183I2R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040546">
        <property type="protein sequence ID" value="VDP15304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2R4"/>
    <dbReference type="WBParaSite" id="OFLC_0001403401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001403401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001403401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001403401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9137" checksum="5881AEFF0664E475" modified="2016-09-07" version="1">MNYRTGRRADGRPSGLEGREYRQTFHPFFSNETERSRKGKKVIHILRPFRLARKLESDEQQNSDFRGNGAKQLILSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3M4</accession>
    <name>A0A183I3M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuralized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14336</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040777">
        <property type="protein sequence ID" value="VDP16596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3M4"/>
    <dbReference type="STRING" id="387005.A0A183I3M4"/>
    <dbReference type="WBParaSite" id="OFLC_0001434401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001434401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001434401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase NEURL1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF6">
        <property type="entry name" value="PROTEIN NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="8">
        <location>
            <begin position="47"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="575"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001434401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="626" mass="70693" checksum="B3546F2119607FDA" modified="2016-09-07" version="1">MLLFNDCLKTGFRFFFLESISDDGLQIANYDENTVVNQGTSEWPLPQLTFHHVHGSNIQILRGGRIARRRESFCKGLAFSSRKLSREILTSNQNVRTDYVQNIAELLEKRSIFEIHNNRIKKFYRPIQIDENVCIRFAEVVSNWSGVLRFGVTNVDPETYHSTELPKFACPDLTSKEGYWAKALPERYSVAGSILHFYVNAEGELYYGINGVLKGQFLNGINVFSPLWVIVDIYGNSSSLEFIGKCFFRQYPNEVRFRSTRSAVSRNRASNRPLSAASVSQAQIATTSTTTHRRHSRNSSTLPVDSDDLLERPEYWVGIKDVAAQPKISDELSFWITEKGEVYFAKNNLAPRVIIHVDTSVKLWAYFDVYGTTQKIRMLGSVKVTTASQLVAQRLPPIPAITRTSRSLLDLSPETRTDVGGSSSELSVFPTTSTYPAHANRENSSPRLSRRTQSETGDSFNEMFLRLPSSPQAERRIPTSVSTVTRPSRPIFMSGEHFIDFLENLENVHVLHGSESNISHRPQFPPPPVPSRASPVRLLPGRPSLYPSPRPPLPAQTSSQQQRSGDDEGEIGDECRICMNSKVNCVIYTCGHMSMCFECATETWHLNGECPICRKKIEDVIKIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4C4</accession>
    <name>A0A183I4C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14586</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040977">
        <property type="protein sequence ID" value="VDP17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4C4"/>
    <dbReference type="STRING" id="387005.A0A183I4C4"/>
    <dbReference type="WBParaSite" id="OFLC_0001459401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001459401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001459401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="217"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001459401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42318" checksum="432F889AE04DF132" modified="2016-09-07" version="1">MKNLTITRGDTVKLVCEFSGDGYLKAKWLHLGQEWPSRSTIQAEQIFNNFSRYNTVAGNNLNVGNTAVEDNHVTVSEGNGIITLTLTTVDEDDAGQYQCVVENEAGTDHGSIFLSIIHAARIVDHSGTKRALKGSIAVIHCGASAVPEPVWTWTGPSGVVYADGSKYILDTQSVTTTLTVQDVDQHDFGKYTCMADNHIGPPDYAELRLIEILPPLTPTKLNCHEHSYPNFGICTIGELKNSPPGKLPSNITFYIVPEDKTNKDNREMGAMNVTFEFDGEHEFKFYHLEPKSRYEVRAQAINEAGVSELSAPDIIETTDPWAPDPPSDIHYDCSRACKMVWNEPNNRGSPIIAYKLILKEIAHTELKQYDADSFELRLETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4U4</accession>
    <name>A0A183I4U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pepsin-I3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14756</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041163">
        <property type="protein sequence ID" value="VDP18614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4U4"/>
    <dbReference type="WBParaSite" id="OFLC_0001476701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001476701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001476701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.50">
        <property type="entry name" value="Pepsin inhibitor-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010480">
        <property type="entry name" value="Pepsin-I3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038412">
        <property type="entry name" value="Pepsin-I3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06394">
        <property type="entry name" value="Pepsin-I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pepsin inhibitor-3-like repeated" evidence="2">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP18614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001476701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13206" checksum="7406E078A5781AAA" modified="2016-09-07" version="1">MNFILQNGVVSINGQMIGNLTEEQKEELEAYNVQTRGWIKQLHQKIEELFKSFFGSIKSIWDRTPISGSEPSPQSSTPDNIITDNLDDQNRKLEDQDGSENSSPFGSLKLPSFCKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I557</accession>
    <name>A0A183I557_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfur globule protein CV3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041307">
        <property type="protein sequence ID" value="VDP19342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I557"/>
    <dbReference type="WBParaSite" id="OFLC_0001488001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001488001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001488001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552778" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001488001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="12137" checksum="A60BD21771A7E69E" modified="2016-09-07" version="1">MISPTLILCIVLLITQGVQAWWFHPMDYHPSLPYGHPSIDGYPPRYRYPSRYRNPSRYRYPPRYRNPPRYRSPWRYPPSIYDHPPYYGPYLPYHFGGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V4</accession>
    <name>A0A183I6V4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042193">
        <property type="protein sequence ID" value="VDP22008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V4"/>
    <dbReference type="WBParaSite" id="OFLC_0001547701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001547701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001547701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001547701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11850" checksum="A5939E560FFF5F4F" modified="2016-09-07" version="1">MNLTTVEFCVLLKKKPKKAKEKFETDKSKEEKKAKQDKIIKKNETNIEPKLLVENHEKGQKEVQKIESGNRLMTIDVAKVDTTVAEKMRPGQKYILHVNNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6X3</accession>
    <name>A0A183I6X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15485</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042231">
        <property type="protein sequence ID" value="VDP22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6X3"/>
    <dbReference type="WBParaSite" id="OFLC_0001549601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001549601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001549601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001549601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14285" checksum="F82162B9937C29A6" modified="2016-09-07" version="1">MFPYKSSILLMFTISNLSTAQFISPFGGFGAFAAPPGLLNPFFGPVGGLGMAMGFNPMLMSTMGMNMFTNPNSYLPSFPNPYASLAFTNNGNSLGYGTQKYGASTYSRRQFMPAYGGCMNRYGCGYGFQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I706</accession>
    <name>A0A183I706_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15519</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042291">
        <property type="protein sequence ID" value="VDP22326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I706"/>
    <dbReference type="WBParaSite" id="OFLC_0001553101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001553101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001553101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001553101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3429" checksum="A867C3E89C35A2E7" modified="2016-09-07" version="1">MTRLQAPYDDGYPSRETHNTDPFTDIHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I762</accession>
    <name>A0A183I762_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanylate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15574</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042386">
        <property type="protein sequence ID" value="VDP22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I762"/>
    <dbReference type="STRING" id="387005.A0A183I762"/>
    <dbReference type="WBParaSite" id="OFLC_0001558701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001558701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001558701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001558701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17414" checksum="AB2F5405BE12623C" modified="2016-09-07" version="1">MKPIVISGPSGGGKSTVISKAMEAYPNAFAFAVSHTTRKSRPGEIDGKSYWFVTEKKFKEMIENNEFLEYATFGGNMYGTSYVSEERLRARKTETEESLKKRMKHAEEDLNAVDADPSLFDFVIINDDFEQAYNDFLMAIKEELNEVASLKGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7P7</accession>
    <name>A0A183I7P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15759</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042802">
        <property type="protein sequence ID" value="VDP23696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7P7"/>
    <dbReference type="STRING" id="387005.A0A183I7P7"/>
    <dbReference type="WBParaSite" id="OFLC_0001577201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001577201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001577201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001577201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23038" checksum="51EEF04DB9E8C5DA" modified="2016-09-07" version="1">MDSDGERGLLAFEVPLCTSTPSSSVTSTRISALPNHNSQILPSFPTSSTLPISTGPMQNKAKCYVRSTSEYSRTMNHSEVGILLLSVDRDRFFDTFVFQDFNDRSGTVRSLPGHLAPQSSSTKDFVKATSSSFDHSRSNFTSNDEFARSCLMNSRTANVLQWEMPRRLSKNTRLTRPAPAPPALIGVKLKPPIPAPRRFPSLTKENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UUT2</accession>
    <name>A0A3P7UUT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000160">
        <property type="protein sequence ID" value="VDO25947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZ21"/>
    <dbReference type="OrthoDB" id="5917019at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="179" mass="21208" checksum="CEEBF9B625CF6F12" modified="2026-01-28" version="1">MLLCQPVRRRTIPIIFLRLSSATSHGAHGEENIERKPADYRPGSDSYAYENPFPKLNRSRLDWLFGDGWRRPLAKDQGGQIRRNWIWFGLSPYDEHADWLKFHQYMFALLTIMVTWVTLYMLYAAPDWPQARDWAYREAHLEMARREKAGLPYISKDLVRPDKIVLPSDEELQNFEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V040</accession>
    <name>A0A3P7V040_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003625">
        <property type="protein sequence ID" value="VDO40596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V040"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="195" mass="22281" checksum="2B20A731B78FC15C" modified="2019-02-13" version="1">MSTFRYVEEIVWPAYRNHLANAYDLARHSSTIVFIDGNVQKFSGESEVKTMLSKLSKNLLLIQADELQLSHAVDFVNTPKNGGISIFLGTTRDNFDGKQVVRLEFEAYDEMVYKELDRLCDELRRSCPTVDRIALIHKVGKVLVGEASIIMAVSAPHRKDAFRATEKGIDYLKSRVPIWKKEVYSDDTYCWKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VP95</accession>
    <name>A0A3P7VP95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001472">
        <property type="protein sequence ID" value="VDO33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H4W8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="102" mass="11415" checksum="21D0968A87153072" modified="2026-01-28" version="1">MFSHSSLHFYIFNHYAPVLLVILALFSLDSNMSWSMVTASRSLQKNSLVAIRNSKAVTLWSLILVIAPATFSMILFATVITIYVKRCKSKPRRVGSDAGTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XFC4</accession>
    <name>A0A3P7XFC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000454">
        <property type="protein sequence ID" value="VDO28082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0Q0"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF322">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="466" mass="53380" checksum="AE98B9FEE49C683E" modified="2026-01-28" version="1">MCDESTINFEETIGKVKWDKYPLKEGDNNSACSEEEAVPDTLTKRIIKLIKILAPHVGLITLLLTYIAIGASMFIWLEADNELQNRRSKLQKVLKLYSMIINETISICMHDGNTTQSSVERRIRPLLSVLSNTHEYDDRFTLNDQLWTDSEEELVTRWSFAASVLYALTVITSTGYDHVTPNTNPGRLFTVFFGLVGIPLMFITAADIGKFLSEIVIRSYTKLLELIEWIGTVIDAIRDYLKDDDDSIDSRKRRPISVKQQSDELAEDEEEERVQLPIASYFGLIIGYCAIGSMLFNSFEKGPIWSFMHGVFFSFNTITTIGLGNIHIRNQLYLALVITYVIIGLAVITASLDLCSSTLKRTFTKLHYFGRKIRGARRGFANVSEDIREAMRIIAALKKTRPSKERITLEDLKRFLEVQEHLLRQPYVPYNVHIFRWIEDAYAQYFDEGSMTGREKNATVDPILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZEX8</accession>
    <name>A0A3P7ZEX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006663">
        <property type="protein sequence ID" value="VDO47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZEX8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="338" mass="39044" checksum="BBD1B55A0DEA96CA" modified="2019-02-13" version="1">MQSVVGSDHPRLIYAAGKDDVHLVDLRVGNSDGDLLYTVPEYDDTSRNSYHFQYEGAFEKETIHQLYSLPDTPQMLLICTSKKFVLVDERMRGLPCLEMAHSIYHGGHHVTSAPTIRDTDRNGSIYSVYILQHTVYPDVQTFSLYRHSDSTMWSSLASIKRLQEPRGAAAFYREQLKYNTRISRLNERLLFGNGPTRAISFLNTDIDSVNQKSFLFRMMDDGSLWYEEISIQDDQNLIEKMLWRGASKVRDIIDSNTSEMRRPDDFRSGSPHQKAKIFNVEFDLDASGNFSFDTNIEALQPLDTHPENSYPEPHIVRDVADEQLFSQIVLQGWDRYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C3G9</accession>
    <name>A0A3P8C3G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040086">
        <property type="protein sequence ID" value="VDP13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I0D7"/>
    <dbReference type="OrthoDB" id="5917530at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF6">
        <property type="entry name" value="STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="405" mass="45431" checksum="F4CA4D5C6FAAC453" modified="2026-01-28" version="1">MEDAYLIAALSIYRNVKFRKIKRIVLEASNMSKYTSARYLKVISMFRHMKHARRSAFLDDIGFSQRPITPGRPRLSKRVSQAGLFSVVIAARCTDPLLWTFSSFLGLFVSALQSIPLATNGWVYITEPRPYNKTNENGDMMDTIFLYNAGYFVMCREYKGGEGAVAEDFRSYLPSEEAAYQCYWNPILTGKDLTEFSSATLAIEGRLALPTSMHIIGVTMCYMAFYFGLIGHIKRSSKTLLAAIMYIFGGLVVLVGVLQFVCVVDDELAPRMKPNAAGEPSKFSFVYGYSFFFTSLSFLPLQMCACCHAFLYFRRFPTALDKMKIVPGLQAQLRRIQVVMALDSSPPETLQKGSICAIVYSNQPSSRKSSRYNLNSPLLIHSPVILPSSFPESLSTTAVRNSVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYA7</accession>
    <name>A0A183GYA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS217</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000060">
        <property type="protein sequence ID" value="VDO25036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYA7"/>
    <dbReference type="STRING" id="387005.A0A183GYA7"/>
    <dbReference type="WBParaSite" id="OFLC_0000021601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000021601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000021601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="71"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO25036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000021601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="62840" checksum="E4DB1B051BAF4184" modified="2016-09-07" version="1">MRLEYVITQSFLQIIVVQLSHAGFISEEWIGSKQNEAVFDKFAKRRMLANGKSDGDEDHSDERKVADAHTRLLNQIKTVALPFQRPIPNLHAPTEIHIRAALYQIFDLDQRNNIATISGYFHVWWIDPSLRWNASEFNNITRTFIPSKWFWKPELYLYHSIQDRVLDYAPDAVAEINIDGRLNLFVPITARVLCPRNVKYFPFDIQNCTFACSSWSYQYEYVSLVVDQREVFLDDFYYSQKWLLENATIHNGTMNYMGHESFSTIYIILILRRQSFYYVFNFVFPTTLVSLVAVIGFHSPINATGRHESKFRLGIMTLLSMSVMLLMLIDELKFALESIPEQKGSFYNVPLLAVFHMIQMLIIGVATCTSSTFVYLEKYALRNQYIEAIPWWLRFLSAKKLFCCYVPKKFRIAGGEDIKRNHDVTTRFVGSASDSFIFQDIIPAEARGLDVNVMECHQETAISEAVAGAPPPINTQRIELLVNLMRELIQMKEEAQRKHYLPTYWKRVIRRLENISLITYFFLIITNVVMFMCHELWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ25</accession>
    <name>A0A183GZ25_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS485</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion inner membrane</location>
            <topology evidence="2 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000161">
        <property type="protein sequence ID" value="VDO25958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ25"/>
    <dbReference type="STRING" id="387005.A0A183GZ25"/>
    <dbReference type="WBParaSite" id="OFLC_0000048401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000048401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000048401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="216"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO25958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000048401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49500" checksum="5B0C458B77F95090" modified="2016-09-07" version="1">MFISSVSIVRASRRCISRLTSHQTCCTLCRITLISRSSSRSAPGILTAWSLGYPSINKADLRMLNDLKGIGRDNEDFVEKGGEKMARKTNQDVYGNTEASFPPKMNVKPNIIVTKWEILMNRCGLPIDRTASKEDQNAQKRKRSTVLAMFFVAGSTFSGLLYFCLYYGWMKRDENSAHTGILAPYYRIKEAYRSWRNFVVEPSRDKLLPDPLKPPYWQPKYTVVIELKNVLVAPEWSYKMGNRVKKRPAVDYLLDVIGYPNFEVVIYTTETALNANPIVEALDSKQKIMYKLYRDCCKYMNGVYVKDLSKLNRDLSKVIYIDFDPESFRFNPENVLRLPKWDGTLDDTALVDLAELLKTIHLSDVDDVRPTLQYYSQFDDPLKEFRERATRVAELEKKMHQMESEKEAFIAPVKKYQGRLFGFRRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ35</accession>
    <name>A0A183GZ35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000166">
        <property type="protein sequence ID" value="VDO25991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ35"/>
    <dbReference type="WBParaSite" id="OFLC_0000049401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000049401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000049401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000049401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12952" checksum="AF897C0E16930A3E" modified="2016-09-07" version="1">MRASAINYWPIERGVVLLRCEIEMKSGDAPPLVYYRRQASSKMCRLLRLDEQQDHSHWKKSHPDIAHSCLLREACRTLKIQPVYTVALFTTKWWSLEKYSSPGLEPGRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZT5</accession>
    <name>A0A183GZT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS745</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000283">
        <property type="protein sequence ID" value="VDO26913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZT5"/>
    <dbReference type="STRING" id="387005.A0A183GZT5"/>
    <dbReference type="WBParaSite" id="OFLC_0000074401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000074401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000074401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF106">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000074401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33387" checksum="A20BF742D94123F3" modified="2016-09-07" version="1">PKVRQIKPWENKLLATICGKTSFHGTFNHPWAVSVALNGTNKLGGVIISPYHILTAAHPFVNFNGYSFIPCKTSTYRTITELLNRKILFGGKCIRGFTDNMANHRICKKADVLDNRIRTIIIDNDFVSENCTKGHDWAIIEVEQPFIFTDKVRPICLPLKNEKLQNILMIFGWGRRHFFDDGSPLIHETQMQLDVNCRASWSDNMPTEVDDYICMKSLNPKHYDTPRICYGDSGSGMQQINDEGIAKIVGITSYGLKGCPPNELARFTRVDCYLDEICQITGVCYTIQNLTIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZY2</accession>
    <name>A0A183GZY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS792</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000309">
        <property type="protein sequence ID" value="VDO27086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZY2"/>
    <dbReference type="STRING" id="387005.A0A183GZY2"/>
    <dbReference type="WBParaSite" id="OFLC_0000079101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000079101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000079101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF192">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="272"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO27086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000079101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66973" checksum="E90FBA8986B8950B" modified="2016-09-07" version="1">MRTFDCIERPLSRLFYRYGRYVAQHPLPFIALPVLFTAFCSISFLHIHPTTDPIYLFTPRNAPSKYERQIIHNLWPLHYNNYIPGRAVTQSREVQVIVASRDGGNILERPYSEAVRRLDFFIQNRVKLHYMGKTYRYRDLCLEWRNEGCPGNKHIHIVSDLYQHGINITYPTVRFGSASGYIGGALGGISLFREADGNTSLAGGLAWFMIYHLKFFPRNISYISGLWEKKLQNALENYPSDPSVTFTYLHSQTLTEELKRNANSLIPRFVVAFSILVFFSLLCSVIFVDGTFYVDWVLSKPILSLLGVINAGMGIITGIGITSFCGVPYSDIVGVMPFLVVAVGTDNMFLMVAAVRHTNRAFPVSKRIGECMSDAAISILITSLTDAFSFGVGAITSIPAVQIFCLYTGVAIAATFIYQISFFCALLSLATEWEAAGLHCIWLQPTVPDTFINSASLKYKLFWMGSRADSDPKNLEKNLKDTSAKTFFKEWFAPVLMNPVVKILVVMWFFIYIGLSIYGCLHLREGLEPINLLVQDSYAIPHYRYLEKYFWNYGAPLQIVVNNAPDLRNRNERRRVQSMVHAFANTKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H073</accession>
    <name>A0A183H073_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS883</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000359">
        <property type="protein sequence ID" value="VDO27443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H073"/>
    <dbReference type="STRING" id="387005.A0A183H073"/>
    <dbReference type="WBParaSite" id="OFLC_0000088201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000088201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000088201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="1">
        <location>
            <begin position="48"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="1">
        <location>
            <begin position="436"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="1">
        <location>
            <begin position="638"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000088201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121995" checksum="4DAC34D87E606152" modified="2016-09-07" version="1">MDNIMDGRLQAYIQEVESREKCQLDDRKKLEDAVPFSEEQLRKMDSTLKRTTAFMKKLKNVGCVQLASILQDMDKINLSKFVEEMAMTIAEAKIKYNEVQAVVTVCVHLSCYYSEFSPLLLLEFRKLLPLKRNDKIQNPSKLRVDIRLLGELCLHGVFGKEGVQLLGSAVSFLTLTDKTEHINIPILLPFCKTMNVDLFGLHPYSMKQAASTANIKLPETSIISADHKKIFTNLLLDYRSSLVDHIKQDLLEMNQLLLSIKRQTRTRGDASAEDRNHLQETRARYEKILMSGTQLSEYLGVEMETMREEQSEDEEEEVSALELSRALQEGTITIWPDEDTRQFYETKMELRQLVPAILFQESEQRTLDLVEGKIEDVDLSGLDTIVEEAEDEGDDHSESVDDEEVKIDLNEMDPSIALSGIEVPKISGQDLKLMMNAFMEQLPWLINRDLIDKAALDFVTNLNTKNNRKKLCQMMLEQYRNRLDLLPFYGRLVATLEPVMPDLALELSHSLLQQFRTAVQNKTKQRVDLKIRCARFISELVKFGIIPKGEGLSCLRMVLFDFRGHNVDMCCAMVDAMGQFLYRSTDSHGKMKILLGVMMKKRDRINDPRQQMLIDNAFYTCIPPTVEEKPKCESDPFQDFIRYLISNLSRYRMEITVRCLRKLDWSDPVCANYAVECLSNPSLPRYNNVPYLASLIAALSSCHDWIGIRVLDATLEDIRIALELNNPSLNQITLLSVIFLGQLYNYSVCDSPIIFKTLYQLITFGAFDPLLDDWNNLTRIVLVCELLLVCGEYFNVGSAKKKLDCFLAYFYRYLLAKEEAFKAHDIIFPKNVRFRVEEMSDYVRKGIKIPKSFDEAQRVIDGIQQQYKKMVDAALEGKVAQQTEEEEMDEEEEEPRKINCAAEAGGDEDISSSEENVVSIHDENERVRVHTNRVLLPEDELFVRQLEQSKTNAVSVPVSEITVPTSARQKFHRSIAFDIPDASTRDIKSGDILDSGTETRMAILTRGKGNKTVLKAIAMDAPSFLTETWNAQREKERKEFTAHKHITLSMNERMMMDDNESLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0L6</accession>
    <name>A0A183H0L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">La-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1027</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000436">
        <property type="protein sequence ID" value="VDO27943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0L6"/>
    <dbReference type="STRING" id="387005.A0A183H0L6"/>
    <dbReference type="WBParaSite" id="OFLC_0000102501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000102501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000102501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000102501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="50093" checksum="7CE763612993D0EA" modified="2016-09-07" version="1">MANKPQLTFARIVSGTVDTNGIGTGSVAITQAPVTVAVTSATAITIATTVSNTTATTTATASSPITDVSTTAMESGNHTSSTTPGGSCVIASAVPYSSGKNKDGLHQRFVEERKPDSNGNAHVQRSILSGPHQQNHYHQQIQRRNKPRLKNDRSRKDDNVLSVGKEENETHTEQQPEVILGPAPLPTVNAWFKHSVTETKESKEESEVLKPHISSAKEEVNSLPLKKMDTEKDNVIKSVAQETLTSTGENNSKKMAKSSLSSQTTKQEKQVDTEATNVDDKAWPSLNEAVNEELKPDNAINNVITKGGAVNHEVIKIIDSSEAVYYTDMKQDRDKENESNGNGGKNNKSGKAWKKLDIDVDYTGREGQGRRGNTGPGNKSDHPQKNSRRGSSFAKQQAIKQYSPSYGVITVPASTTENVAKIVPALAPASLLGCAQPLSYIAPAFIYSPECATISDEYAEEDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0S6</accession>
    <name>A0A183H0S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1086</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000466">
        <property type="protein sequence ID" value="VDO28187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0S6"/>
    <dbReference type="STRING" id="387005.A0A183H0S6"/>
    <dbReference type="WBParaSite" id="OFLC_0000108501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000108501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000108501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000108501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60809" checksum="737AADC9EFF3BA03" modified="2016-09-07" version="1">MGIRCIYGDQRVSRVVPDSYFLDYFSAKCLISSNAWVICQFAKDLSAEHLLAIGDENGFIHFLDARENVIRNSISADRSCVIDLSFVANRPNNLLSISGHAKVTSWDIERQFALQQFLGHEGSVRALSVSDDNPDLFATGARDGTICIWDRREPQAAIVRPFNLLENTHPLLAPERQSIGTKRRSRISVSMSSKGITSLVHLGGNTLISASSSFKTGIRFWDLRYRGKNSPFRILEDPNSTSIRDFGVASICLDRFSSSLFVASTDSKIYQYSVQGLNNAPVSVGILQGVKRTSFNTYDFKIAASPTSDHVMFGGGDCFAVIWDLQEKYSGSSKGKMKYLPYPKYTLGGHRYEVTVARFSSNGHYIATMDDSYLKIWKWSARSPENQEPSPITVHEDHVELYELPETSIAEITLKQLNVSVSTPKKNTERSPFKSPFKNPLNRTGTQTKNGSESPVKKILKVTESMSPPLCDLTNKSSHAVRRIDFSGTDMKNRISCAFYFKYPTMNLPDFVRERLAALNVNSEPQATKLDKRKSPELDEHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H137</accession>
    <name>A0A183H137_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1197</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000529">
        <property type="protein sequence ID" value="VDO28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H137"/>
    <dbReference type="STRING" id="387005.A0A183H137"/>
    <dbReference type="WBParaSite" id="OFLC_0000119601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000119601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000119601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000119601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35744" checksum="3DD2F731DDF8F166" modified="2016-09-07" version="1">MRITHPYCIDISLCLNLSGKDRQRSSLKTLARIFLDKEIQGENGHCSVDDAIITMQLLKYKLSHGVRFGNVSLGWSFDDWARENGLTTSGARIDKSKNLCSEARIAEGPQRKRRCLDVNENKNWCLQKSVVRTCDKCGRPLSVACIVPYCACKKNIVKYCVMCCLNSLPPQTSSEEPTLIWSDAFQACAGGSEPISQFLQLNKSKSAFYAIPDGIKDNANNEHEMYVNTNAYNSLDELVKRVSEEIISHNVVMVDIDAERLKMTIDGRSIIAVDNALREMISYASWNSLIIVVFSSPQESLCYINVKTQNHRTVLTDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1D8</accession>
    <name>A0A183H1D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1298</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000588">
        <property type="protein sequence ID" value="VDO29017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1D8"/>
    <dbReference type="STRING" id="387005.A0A183H1D8"/>
    <dbReference type="WBParaSite" id="OFLC_0000129701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000129701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000129701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000129701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21991" checksum="E53EA32FF02D43B6" modified="2016-09-07" version="1">MDVKVGLTTKEAFAKLCDILESEIDKESKLVAESFAFRFLAHNSLITGSFCIIYAIASIVCCLVLLTCSLLRDCALFDQFASVLLLIITVFNICHSLKAYRTQRFTIVARASSILNNLKSLKEEDFEYEHLYAPPSDAISLQWTYRDQKLVNVPWMLLVDGDVIELRAGQSSPCRCMSQHGDIIDLGDKPRFLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H230</accession>
    <name>A0A183H230_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000742">
        <property type="protein sequence ID" value="VDO29913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H230"/>
    <dbReference type="STRING" id="387005.A0A183H230"/>
    <dbReference type="WBParaSite" id="OFLC_0000153901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000153901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000153901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000153901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="32341" checksum="7D7F32BBC3879508" modified="2016-09-07" version="1">MKKIWKSFLRSVKNRNYQQKAIKYAEDMEKTGTIHRAPRYPTEQKHFQKIQADEKITKEIRKRDDVLIDNMNKITVTSSEPKNRWTPTKELRTKNTEWILRARCDKDFVLKLNEERRDILLLQILESLEKHPAMQRIDNEAFSIIWQYFRPFERKEQQYIVKRKDIDELRDAMLGFSKESKMPTFEDLKRMREQQLEAESHTQTSLEGSLNEDEKERLKRLEKIKELKVKEDVRLSQELEKLGLMDEDKKSDEAINDNAEKRRLEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4E1</accession>
    <name>A0A183H4E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hist_deacetyl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2350</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001333">
        <property type="protein sequence ID" value="VDO32689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4E1"/>
    <dbReference type="STRING" id="387005.A0A183H4E1"/>
    <dbReference type="WBParaSite" id="OFLC_0000235001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000235001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000235001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000235001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42297" checksum="410BF8FA79208B72" modified="2016-09-07" version="1">MAEEKFVDGNDRSSIEKPLANKQLAAVKASKLYKEIARDQLPIIYHPIYNISFCGIERCHPFDSRKWGRVYETLLRKLPSCESGMFEERQTIRPLEASMDDLRVVHSSVYLSSLRCPCYVAKIVEVTPVAFIPPCIINKVLLTPFRYHTDKFDKHIAISKLLYISIHFNARGTILAAKLALTSGWAINIGGGFHHASRSKGGGFCIYADITLALTFLFINQLISKAVIVDLDAHQGNGHENDFSGDSRVYIMDMFNNRIYPNDLRARRSIRRSVHLRIGIQDAEYLFLLSSNLEDVLSEFRPDIILYNAGTDCLRGDPLGLLSISSKGIRKRDEIVFKMARDRHIPIVMLLSGGYMPNTHRELLLKECKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4E3</accession>
    <name>A0A183H4E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2353</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001336">
        <property type="protein sequence ID" value="VDO32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4E3"/>
    <dbReference type="STRING" id="387005.A0A183H4E3"/>
    <dbReference type="WBParaSite" id="OFLC_0000235201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000235201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000235201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="85"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000235201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37743" checksum="4135C6825591C341" modified="2016-09-07" version="1">RTPVSGGKTWTRGASISTHPHTYINHNSILGDHCEVCSGWIGIVGKQAYKCCDCGLHVHKACIDNAPMPCVPRTPTSRTPSKQRPRLKDLCPPTQPMIPPILIHCILALEKNRLCSEGIYRIPGDDIQVQKLLNEFQNGRSIPKLDYHDTETITSCIKQFLIKLRDPVIPSTSWEEFVNAAETDDIITLNNGIMDLPYPNRDTLAFLCAHFQKICNNCIQNKMPPNVLARCVAAVIIGPAPPHVLKTDEEAKQVMVMLALLRMPPDYWPKFYNFDNGIPLINSPKCKSYDNKKPVKTPYKNPNKSILGPVETPPSGQEANTYRPKISGRKHFLGDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5I6</accession>
    <name>A0A183H5I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2746</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001653">
        <property type="protein sequence ID" value="VDO34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5I6"/>
    <dbReference type="STRING" id="387005.A0A183H5I6"/>
    <dbReference type="WBParaSite" id="OFLC_0000274501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000274501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000274501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000274501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18957" checksum="1C0FD40298BC5570" modified="2016-09-07" version="1">MFKTACCLAINSLPVTIKRIECAIIDYAFLQGWMQPHKPNYSTGKRIAIIGSGPAGTGRLQNRFSGMAAAAQLNKVGHAVVVNEKKNHAGSLIRVKLLEDEGVRFITNTEIGKHVPADFLLRKSQRIVADEEDTWEGLNANGKRVIILGGGTADCIATYTRLLCFDIVWTPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H653</accession>
    <name>A0A183H653_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2964</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001850">
        <property type="protein sequence ID" value="VDO34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H653"/>
    <dbReference type="WBParaSite" id="OFLC_0000296301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000296301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000296301"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="13"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000296301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43669" checksum="C6FA8472EC9E5DCB" modified="2016-09-07" version="1">MIASFIAWLGTCGNLLLVYIFVTRAYPTSTKFLTVLAILDALICILYIMLFGIDAAIVYLKVSNLFILYHIYIVPAFVISRITQLAIPYMLILTTLERLVWISGGKTTKFLKRMFSDRGHQITVFLLLLCCTISRLPTAFAIVVHHFPNCNDFLRTQSTGPADWVHKSKVYYFFDFHLLSIAQTFIPFIVLVVFNFIIIRKLPKENLDQQKKSINGDYLLCPDFTSNKNQLKKEQNKHSKSNALSVFDRSNQSASMLEHKLSIITIRPFCKMSTPVRDAICTMLAIVTSYLISNSLHLILTVLERSNISILRNPDDPMMASTFHTVFSDTVSFVYMFTSAIRILIYYMCNPAVRLHLREFLRCYHRNRKKRSPSTITVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H688</accession>
    <name>A0A183H688_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorein_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001876">
        <property type="protein sequence ID" value="VDO34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H688"/>
    <dbReference type="WBParaSite" id="OFLC_0000299801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000299801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000299801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000299801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16140" checksum="EAA51DFCE3960888" modified="2016-09-07" version="1">MPYPQWGVGESGLYQTNKFFLILSRNTRGLIGEEKMLENLVAWVLNNYVGEYLENLNTDQLSIALLQGQVELENVPLKKSALCKFDVPLKKKLENSGTFIAFLHGTHCFPMWSLLSYVELSVVDCGFALANYPSLLKKKFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6V1</accession>
    <name>A0A183H6V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3213</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002080">
        <property type="protein sequence ID" value="VDO35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6V1"/>
    <dbReference type="WBParaSite" id="OFLC_0000321201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000321201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000321201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000321201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16668" checksum="775F0006CAA5444D" modified="2016-09-07" version="1">MRHDLIKMSGNHPDPEHWKKEREKEEKQKELLPPNLEPKYFPAKKAISLLAIIQLMLASSQFIENTVTLHRNFHDFYDGESRSYLFFSLVVTIIWAFTFCWIICTFILLIGLFINLPSLLLQHIVFSVNSYCSQLFAIFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8A2</accession>
    <name>A0A183H8A2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3714</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002583">
        <property type="protein sequence ID" value="VDO37528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8A2"/>
    <dbReference type="STRING" id="387005.A0A183H8A2"/>
    <dbReference type="WBParaSite" id="OFLC_0000371301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000371301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000371301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000443">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO37528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000371301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12854" checksum="2A4E21FB13ADB049" modified="2016-09-07" version="1">MMDGPPERRSRSRDHTAIRGFNHFKGIVLKTLIRHPKKPNSGNRKCALIRLSNGKEVCAYIPGVGHNLQEHSQVMVRGGRRRDLQGVRAEVIRGKLDCAPLRKKAKKAAVKLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Y3</accession>
    <name>A0A183H8Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3945</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002817">
        <property type="protein sequence ID" value="VDO38318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Y3"/>
    <dbReference type="STRING" id="387005.A0A183H8Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000394401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000394401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000394401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000394401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10521" checksum="2320A1A35ABF3001" modified="2016-09-07" version="1">MSGDDPTRDAMTEVVKMDRCEDKDDNMDGIRSGMIRRRQRLLSLSVPPMPWFGIDIGGTLVKLVYFEPEDHASFLIVQKLRRIVEQHILPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9B9</accession>
    <name>A0A183H9B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002965">
        <property type="protein sequence ID" value="VDO38806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9B9"/>
    <dbReference type="WBParaSite" id="OFLC_0000408001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000408001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000408001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000408001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8238" checksum="0A01EB576EE46D77" modified="2016-09-07" version="1">MAYCGYDQRTSLVTVHRIFAASSCVAALIQNDAEAEQIVNLPGLTFAPNLRNIPVSCLQKLEISCIINMSDRIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9I4</accession>
    <name>A0A183H9I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003039">
        <property type="protein sequence ID" value="VDO39083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9I4"/>
    <dbReference type="STRING" id="387005.A0A183H9I4"/>
    <dbReference type="WBParaSite" id="OFLC_0000414501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000414501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000414501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000414501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21729" checksum="129191FB86902DE4" modified="2016-09-07" version="1">MITIAPLDGFKGGGEGKYYAEVTLLSHPHIEASIMRVIADTMIEWRRQLLGGSCQPLDSNSVAARNLITIFDFFLSHGFNKGNRLYWQFVKEFMSRNETNYLKREWRVISTQQLSVAWLKDVLNKQTLLYYFQKYYLLKSLGLTSVSSDAFLDIETVFAPRKRMKMAVEFHKTVLFCEIWLDFGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9K4</accession>
    <name>A0A183H9K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003062">
        <property type="protein sequence ID" value="VDO39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9K4"/>
    <dbReference type="STRING" id="387005.A0A183H9K4"/>
    <dbReference type="WBParaSite" id="OFLC_0000416501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000416501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000416501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000416501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26740" checksum="03A25678010E72C5" modified="2016-09-07" version="1">MISDVEKVNHSYDVACRVWCVQWNHAGTILASCGDDKTIKLWKRIDDAPYLIYSGTIKGSHNRAIRHVAFSPNDKFLASAGFDAAIVVHELCNNDYEEINRLEGHENEVKCCAFSSSGEYLATCSRDKSVWFWQLDESEDFEIASILQSHTQDVKFVVWHPVDELLVSCSYDCSIRFYRFDGEDWITQQKIENAHESTVWSADFSDDGNSLATVGADFSINVSFFAKTFFFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAZ1</accession>
    <name>A0A183HAZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4653</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003642">
        <property type="protein sequence ID" value="VDO40638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAZ1"/>
    <dbReference type="STRING" id="387005.A0A183HAZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000465201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000465201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000465201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="7">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000465201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32998" checksum="F20D4130C792942A" modified="2016-09-07" version="1">MDIRDEREPGECSRTPSPESEVTHINVQRTPKRKTTHRYENAKFRNESLIEQIDLVTEDHDEDIEILQISDESECNGDGELFVLDTEGAEIVEVEEINRKSLIKTPKHDLEKEERKILQKASKTKGKDNIFDVSRILTNDVVVPSPSEEKKESAFKISCFNCAGEHTLQQCDIPLNQRRIAANRAAHFNNKRSAQERYTTVDDTASAGTCNTRPGEISDALREALGIGPNDIPEWIYRMRRRGFIDGYPPGYLAEALDQSSGEESLLEFHTDDKTLGTPRTLRGAYFTCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB35</accession>
    <name>A0A183HB35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS4697</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003693">
        <property type="protein sequence ID" value="VDO40769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB35"/>
    <dbReference type="STRING" id="387005.A0A183HB35"/>
    <dbReference type="WBParaSite" id="OFLC_0000469601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000469601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000469601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF240">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO40769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000469601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18140" checksum="584176E7D71AF815" modified="2016-09-07" version="1">MAGNAYDEPNALSAEAIPSTTSIALKPGTGKESDENSVLSEKPTAVTINDFIFIKVLGKGSFGKVMLAEHKRTDEVYAVKILKKDVILQDDDVDCTMCEKRILALAAKHPFLTAIHSCFQTVASLADRLFFVMEYVNGGDLMFQIQRARKFDEPRARFYAAEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA4</accession>
    <name>A0A183HBA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMR1N protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4767</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003793">
        <property type="protein sequence ID" value="VDO40981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000476501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18859" checksum="68A50CB5E5DB00F0" modified="2016-09-07" version="1">MRQALCTVVGIYSCSLFAIQADFFEYAERVQCGDVISSETRRHVDAYVCPTKFHREKENRCCNPPRFNCCREPTFLENHLTAVLSTAIIVIFALLTMIIIVCLCWEKCLLHKIIRKKPALDYMARPEETEYLSGLSLPNEYCSEKHAYEVNAEIIYRPNKDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBW3</accession>
    <name>A0A183HBW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004064">
        <property type="protein sequence ID" value="VDO41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBW3"/>
    <dbReference type="STRING" id="387005.A0A183HBW3"/>
    <dbReference type="WBParaSite" id="OFLC_0000497401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000497401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000497401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000497401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12582" checksum="B06FAC953EB8446A" modified="2016-09-07" version="1">MRNRPLGYTDKKEISTFLLEMSGNSSHSHSSRHRLSSATSGSPPNSRQILSQASSNSTRTSQSRSRNSYRQSSSLQEQEIVEDGNIQNREQEAIQHVQNERHSPARSQLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCL2</accession>
    <name>A0A183HCL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004374">
        <property type="protein sequence ID" value="VDO42432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCL2"/>
    <dbReference type="STRING" id="387005.A0A183HCL2"/>
    <dbReference type="WBParaSite" id="OFLC_0000522301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000522301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000522301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000522301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25813" checksum="666B558AB85C0D76" modified="2016-09-07" version="1">MVYLYISESVLNIFLKQLSTFGDTALQLHADPEFQKMLRLKCPDDEECMGDLLQDTELYVPDSGQMIIKIRSPLVASIRDNFALIDLHLTSFVTYKQEDMDVKVLEFEWLATVHVSNEYLNEHLVEKYEPMQNINTSLQVVNLVINNTTPYVEMISNYGEHLLRLISLRKKLLEKLLTEQCSLTKTTSTLYKAIYYTASFRNGTLVIGTDLKWSPDLFHQFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCN1</accession>
    <name>A0A183HCN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5243</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004406">
        <property type="protein sequence ID" value="VDO42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCN1"/>
    <dbReference type="STRING" id="387005.A0A183HCN1"/>
    <dbReference type="WBParaSite" id="OFLC_0000524201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000524201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000524201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000524201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19765" checksum="CA7A1CC231DED920" modified="2016-09-07" version="1">MDKRIELELRGRDPSEVTELNLDNCRATAVSGLTEDFRSLETLSMINVGLTSLKGLPPLPSLQRLDLSENRISGNLDQLLCCPHIEYLNLAGNKITALEVLEPLKKLKELRSLDLFGCELTTSDDYRKNVFEDEDETEDFAPGDDEETDEAGSPRGVKRKHEKDDDEDDEGAKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCR5</accession>
    <name>A0A183HCR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5276</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004451">
        <property type="protein sequence ID" value="VDO42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCR5"/>
    <dbReference type="STRING" id="387005.A0A183HCR5"/>
    <dbReference type="WBParaSite" id="OFLC_0000527601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000527601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000527601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="LpqB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Lipoprotein LpqB C-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000527601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48003" checksum="BE88288F000E32D1" modified="2016-09-07" version="1">VAIHPSGTYVFLVNEAGQAQYVNLITQTILYRHNFRARVSDVKFSMDGRRLAACRGGDVQVFLVAGIENFQLNPFMLLHTHKITAEKARTIEWSYDDKLLVVGSEDKQVRVVSAIKNLKNLFLHALAAHKAEVVGSHFCHNSYDLISVDKRGLANHWTCALKQEDFVERLQSKNAFEDVKKMWYDKTKRHNMMEHLDNAQGVNLTATTYHPSTSLLVTAFSNGAFLLHEMPHFNLIYSLRVSETKVSHLAINKSGDWIAIACGKGSEGQLVVWEWQSETYVMKQQSHSQSIKTVAYSPDGSQIATGAEDGKVKVWSCHSSFCVVTFTDHSSGVSAVCWTSDGKALLSASLDGTVRAHDLVRYRNFRTMVCPDKTQLGCLAIDSAAELVMASSVEMFNIYVWSLENGKLLDILSGHSAPVASLSVHGQYLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD87</accession>
    <name>A0A183HD87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5447</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004689">
        <property type="protein sequence ID" value="VDO43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD87"/>
    <dbReference type="STRING" id="387005.A0A183HD87"/>
    <dbReference type="WBParaSite" id="OFLC_0000544801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000544801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000544801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase DDX60 PIN-like" evidence="3">
        <location>
            <begin position="93"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000544801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37392" checksum="CAE17A8CEAA18AE7" modified="2016-09-07" version="1">MSDWDNLDSLVKVDAIPIKKTAAVKVASSLEEQNIIFTKDDDDSDIENELSTSISSKNDIELESEDEEAGDIVITNDFTIDDVNLVEILNRFNSKYDNIISEFADVEIFLISLDGLLIELTAHRYLNWTLGGQTIVIAKQIEILLKQLSNLGGKFKLIWFTDLSATYAKDTVLNFLRSFIAAYLLQCQWASDIEYFANPADPRWLSYMHELMPSFLMIGVDDVSENVVADTSLGFKQLLASIALQALASTIPIVYFNGLVVNLCSVYSHRVEPHIVDFKGWTNYLFELWADKKNEVQRNIDLSSCKSISQLWAQIIGTCKKRLLRYFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDU8</accession>
    <name>A0A183HDU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004983">
        <property type="protein sequence ID" value="VDO43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDU8"/>
    <dbReference type="STRING" id="387005.A0A183HDU8"/>
    <dbReference type="WBParaSite" id="OFLC_0000565901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000565901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000565901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000565901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14944" checksum="2B152743A151525D" modified="2016-09-07" version="1">MDTVTIVAALLHDTIEDTATTLQEINDLFGEEIGHIVQECTDDKSLPVSVRKQLQVKNAAKHSHKIQAKLVHLADKLYNLRDLERETPVGWSAQRVKEYFIWSKAVVSELKGTNEALEIALDDVINRYLCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HES1</accession>
    <name>A0A183HES1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5983</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005442">
        <property type="protein sequence ID" value="VDO45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HES1"/>
    <dbReference type="STRING" id="387005.A0A183HES1"/>
    <dbReference type="WBParaSite" id="OFLC_0000598201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000598201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000598201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000598201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21228" checksum="BEA45949066D591B" modified="2016-09-07" version="1">MFQLFRTFDAVQKHQKRQHEVRMRPKCETCQKEFPTGSLLREHVAIVHLNLRPFKCTKCSAVFGRQGCLRRHDMMRHLNYVYVCPYKQCTHAGFKCSKALTAHIRSVHTHVRPYGFSLILYKCEQCGKRFVRRNDLRVHSDIHNTACKYICPTCKQMFRRRIHFQKHIKKFHPKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF52</accession>
    <name>A0A183HF52_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6113</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005630">
        <property type="protein sequence ID" value="VDO45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF52"/>
    <dbReference type="STRING" id="387005.A0A183HF52"/>
    <dbReference type="WBParaSite" id="OFLC_0000611301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000611301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000611301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000611301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14407" checksum="CE639A387DCEFFE9" modified="2016-09-07" version="1">MCRRMSLDQLDKVVLPLPDGAASSQILDEVMIRQMVDVLPARAAGYPWINIYNSEKHGFSLHTFYRKMIDWDEEMSPTLLIIRDCNKNIFGAVVSTTVRPNEHFFGTGDSCFLYKYVDDLELNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGQ7</accession>
    <name>A0A183HGQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DAZ-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006479">
        <property type="protein sequence ID" value="VDO47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGQ7"/>
    <dbReference type="STRING" id="387005.A0A183HGQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000666801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000666801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000666801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000666801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20968" checksum="50684213C481792E" modified="2016-09-07" version="1">MKCPSMNEKYSSLPIPRMVAAIDPRYNNSVQMLLARQRCNPNALYDYATISYDDLCTSSSNYYHQPSQQNQYYFNSVTPVTFVPNPSLSSTVRPEMGTFHFRPPPNFPPPPPPPSPPPPQPASSTSLSGIRQHSPTPLSSASIARVSDDSAYSDSSASTLQCHGEVVTSNRSGMLLRMDLSKNPPVFVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH56</accession>
    <name>A0A183HH56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6817</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006707">
        <property type="protein sequence ID" value="VDO48005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH56"/>
    <dbReference type="STRING" id="387005.A0A183HH56"/>
    <dbReference type="WBParaSite" id="OFLC_0000681701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000681701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000681701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000681701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11538" checksum="8D0B8DB34200BF14" modified="2016-09-07" version="1">MLFRSSDCSPLKKRKKKNKILEILDDWSIFIGNPVKVGLGMVSMVFDVIFMVQHYCLYRNADEGVILNTSEENITNELDQSDINILPEVVRVNDEQHIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHB6</accession>
    <name>A0A183HHB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPN1_RPN2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6875</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006808">
        <property type="protein sequence ID" value="VDO48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHB6"/>
    <dbReference type="STRING" id="387005.A0A183HHB6"/>
    <dbReference type="WBParaSite" id="OFLC_0000687701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000687701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000687701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000687701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45714" checksum="1DA317852269AFF2" modified="2016-09-07" version="1">MLKTIIKFVHLSFRLEQKQMAILLGRHQIFLELEGVENGDKLMELNSNTNLHAYFHSLARELDIMEPKTPEGIYKSHLEQSRPFAGSSASDSVRSNLAAAFVNGFVNTGFGVDKMMTEAEDASRWFYKNKEYGMLSAAASQGLVWRWDIDTGLAQCDRFLYVNDDFIKAGTLLAIGIISSGIQDTCDPAAALLMDHINSDRTVMRIGSIFGLGLAYANSKRFAMLKKEDGGVVFELKKLLLDTKPSATSEVKGLAALSIGFILVGTCDHITACELFNYLNEKTAVELQDSNYRFVALGIALIFLGAQQKSEVFVEMVRALPDPFGTMFSTLIDVCAYAGTGNVLKIQKLLHICSEHYETKETKEAKKKVKFLCLIGSILSHSCILLFIHVSSVLSPISYYFCKVMLIGFVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHG7</accession>
    <name>A0A183HHG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6929</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006904">
        <property type="protein sequence ID" value="VDO48511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHG7"/>
    <dbReference type="STRING" id="387005.A0A183HHG7"/>
    <dbReference type="WBParaSite" id="OFLC_0000692801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000692801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000692801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000692801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12308" checksum="6D4169355E63990B" modified="2016-09-07" version="1">MLSCANVLNEEGHRMVIAFMSGNKENVSVHPYPHLGNLLTLKLSETYEDELRPDGTVQKMRVETFFQMDYRTGEWKRLRKTRALRPEEMRTLHQTIMQSAHTAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI80</accession>
    <name>A0A183HI80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007335">
        <property type="protein sequence ID" value="VDO49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI80"/>
    <dbReference type="WBParaSite" id="OFLC_0000719101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000719101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000719101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000719101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8025" checksum="40140671A6767A76" modified="2016-09-07" version="1">MEIKEVEKQCRLEHYGSVKVKDARNNKRGGHHRGSGQRRKSKNQDSDKHEDTIYVKIFDIDPQKFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIA4</accession>
    <name>A0A183HIA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007387">
        <property type="protein sequence ID" value="VDO49870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIA4"/>
    <dbReference type="WBParaSite" id="OFLC_0000721501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000721501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000721501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000721501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20835" checksum="B554AEDAD51410B9" modified="2016-09-07" version="1">MIDQARYKHYQHRNKFKEAIDYLDQIFEDLKKEGDEVDKMQRSREIPTALMHKGTSNDDLVNSAVPPVKLRQHNGIAKREVMKEMDSRKKPIVTTNRHSLHASKSKIAEKHCLQEKAASFEQTLGDVETSETIVLPVQNRKLKGERMDFTRRWLTGDIKSLVSVQPKPDLILGGVEEFLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIA5</accession>
    <name>A0A183HIA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007390">
        <property type="protein sequence ID" value="VDO49878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIA5"/>
    <dbReference type="STRING" id="387005.A0A183HIA5"/>
    <dbReference type="WBParaSite" id="OFLC_0000721601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000721601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000721601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000721601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13952" checksum="B44A5E3C8082E6FB" modified="2016-09-07" version="1">MVFVMGDSRNDVKSKKIAFRRKLCVAVSDSDGSPVISFNITDNIIHPSASFFYPSVEYWKFWKGGEGVIRISYERFDKHESEGASSGGCGRSSCLKRRFSRNSQRNQVFTCFLSYTDHLMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIG0</accession>
    <name>A0A183HIG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7272</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007469">
        <property type="protein sequence ID" value="VDO50155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIG0"/>
    <dbReference type="STRING" id="387005.A0A183HIG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000727101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000727101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000727101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO50155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000727101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25264" checksum="E26BC9C15478405F" modified="2016-09-07" version="1">MKTDTNLSISYRIFAHTYVLLTYRNTYADQCEYMALPWECFLMRTPITSTLLLNATSIPTIVIERAIATYCSSRYEKFSKNIAVILVIAQSIIGIGNFLFLVSDFELFGSEKVVYCSSANDGNALKSAIIFGFYMIIDFISALTFPVLFFINKRFRRTKIHANLSQRYQITENMNSIQILSPMIAFHSILVTFYMGALFLPFAVGFKFSYKQFAVYLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ40</accession>
    <name>A0A183HJ40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7502</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007881">
        <property type="protein sequence ID" value="VDO51288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ40"/>
    <dbReference type="STRING" id="387005.A0A183HJ40"/>
    <dbReference type="WBParaSite" id="OFLC_0000750101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000750101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000750101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF282">
        <property type="entry name" value="CUTICLE COLLAGEN SQT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO51288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000750101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="23295" checksum="34FA2BD3EC832CD6" modified="2016-09-07" version="1">IITECAKENTCPAGPPGPKGPPGHAGLDGRHGIDGKPGKDAENMSTLHAEAPCYHCPRGLPGIPGAVGKPGLRGIAGAKGRSGVPGRNGQPGPPGEPGPPGAVGKDGEMGPPGSKGLDMHHLVGRPGPKGLRGPPGPAGSPGNKGAEGQTGKAGPQGQPGSPGPAGPSGPQGPVGPEGEEGRPGKDAEYCPCPTRKSDITYHRSKEQKARAMSYNYGDNDRKSVSDGPTYRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKY0</accession>
    <name>A0A183HKY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8142</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008981">
        <property type="protein sequence ID" value="VDO54212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKY0"/>
    <dbReference type="STRING" id="387005.A0A183HKY0"/>
    <dbReference type="WBParaSite" id="OFLC_0000814101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000814101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000814101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000814101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29762" checksum="D7D23A701433CFD4" modified="2016-09-07" version="1">MEQKYIFNSIDLQRKEVATEKKDMLSCCKQKTNAITELRKTENSRKRQNQITKQWLQPSFDLDSSKSRKEQQLEFLNINVSSLCYSSKKDLLEQESQIGTGSYSRTNEIVRGATNLCKKAKMNEENMVISLLKFDHEMELSTTDADRETFSHKRINETDKNKNEFQVGNLLDGKPIFSPETSVLNSVRRISKEQLTNTSSRNRSSVADDCFSSFKFESDDEDSGENRSLLENEGKLISNTLSCFYGLLFSLVILGIGQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL52</accession>
    <name>A0A183HL52_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8213</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01009116">
        <property type="protein sequence ID" value="VDO54595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL52"/>
    <dbReference type="STRING" id="387005.A0A183HL52"/>
    <dbReference type="WBParaSite" id="OFLC_0000821301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000821301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000821301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="11">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO54595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000821301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17237" checksum="28302C422EF9B612" modified="2016-09-07" version="1">MKKSWPNIPWHIYAITCLRLHIRHLSARQIRSSFLEYFKEHDHTYVPSSSVIPEDDNSTAFVSAGMNQFKPLFLGAKYTEGKFAGLRNVVNWQKCIRIGGKHNDFDDVGRDLTHHTFFEMLGNYSFGGYSKVIGFYAFLLFFLLLFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLA6</accession>
    <name>A0A183HLA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CLEC16A_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8266</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009207">
        <property type="protein sequence ID" value="VDO54857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLA6"/>
    <dbReference type="STRING" id="387005.A0A183HLA6"/>
    <dbReference type="WBParaSite" id="OFLC_0000826701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000826701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000826701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000826701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22544" checksum="A89C1711BA00C784" modified="2016-09-07" version="1">MTLFITENSDLLACTVITNEKSEKFHQFLVTDQAQLILVEPDNKRMGWAVVRFVGLLQNTQLTSDLENSRALHIIVNDANNRSKANDTVYFNAKFLFDDHIRCMAAKQRLTKGRQMARQCKLDQICDLLGIARKASIWRSNKNPFRIVKGCPPGSLRRQPQLVSPRSSRSSNSSLNIVPDDPEHGTDSSVNKDWKVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLG0</accession>
    <name>A0A183HLG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009299">
        <property type="protein sequence ID" value="VDO55099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLG0"/>
    <dbReference type="STRING" id="387005.A0A183HLG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000832101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000832101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000832101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000832101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20859" checksum="52BA64CCC091DCE0" modified="2016-09-07" version="1">EKLQNFVIKVLVHFVKTQKLSGLKEVTDYQNMFGGFGEAVHKTITTEHTSVISVNASTSNNNIHSAVLHRSGSDRRPSVSTQQQQRLVIGTKQPGTSLSNSSLYMVRPQSSSVSVRNSTQQPYVNIISGTRLQQSTPVLSRPAQQNTYYVSSGTNSPTNSYVVRPSGYKKMIVTSQRGTSSSTNDSFRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLY3</accession>
    <name>A0A183HLY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009653">
        <property type="protein sequence ID" value="VDO55946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLY3"/>
    <dbReference type="WBParaSite" id="OFLC_0000849401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000849401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000849401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000849401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6140" checksum="CA45CE13A59FBE89" modified="2016-09-07" version="1">MQRERRVVNDKALNRISLQKLMLKGSDCKFKPQTLVSMDLALSVFSPANFSDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNF2</accession>
    <name>A0A183HNF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9014</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010659">
        <property type="protein sequence ID" value="VDO58385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNF2"/>
    <dbReference type="STRING" id="387005.A0A183HNF2"/>
    <dbReference type="WBParaSite" id="OFLC_0000901301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000901301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000901301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO58385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000901301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22430" checksum="396DAD709259E845" modified="2016-09-07" version="1">MSCTESYIGSSSPPTTYPHYAEWSSSGGGYISTSATPYPPTSSYGHHLPPPSTSQWITNAANYVQNQPTANARPTEQSQSVTSAASTAATVAAAAAAATIAASTANTYKWMHIKRTVAKSSVPKRRVVEDSNAIRTNFTTHQLTELEKEYYTSKYLNRTRRAEIAAILQLNETQVIPYLNYLICFIKLLQNKFSIKQIEVVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNF7</accession>
    <name>A0A183HNF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9018</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010665">
        <property type="protein sequence ID" value="VDO58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNF7"/>
    <dbReference type="STRING" id="387005.A0A183HNF7"/>
    <dbReference type="WBParaSite" id="OFLC_0000901801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000901801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000901801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000901801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15668" checksum="A253B534EB4F647A" modified="2016-09-07" version="1">MLSFGNVERGQKGNRNNKVENSGCSKKKKMLNIPRQNWWELFIIFVYFFHIHHLPIIILLFFLRRRNIKCLESIENRSKSILESDEEPDAFDTNEQSSSSSIRERFNTLQDTMAKVQNTMDFIASLLERIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP59</accession>
    <name>A0A183HP59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlnD_UR_UTase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011205">
        <property type="protein sequence ID" value="VDO59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP59"/>
    <dbReference type="STRING" id="387005.A0A183HP59"/>
    <dbReference type="WBParaSite" id="OFLC_0000927001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000927001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000927001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000927001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24755" checksum="41F0A96F652A4E4C" modified="2016-09-07" version="1">KIYRQPIAIALSVFGHHFDEQLLRNLIIARQRTLGDRPFESLDDIRRYGIETTGSVIQLIMHLLSGCHLAKKEVLLSKETIQAVESMSHAISIITLIRSVMPLLARGIFLIPSDLMEKYQLRADDVLGNKKQNALRDLVKELTNIAEEELLKSRQFRRSIEPNLRLALMASGATLDHLVKTLHKSNYNLLNTRLQRGYDLLAWRFWWRKLLGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPB3</accession>
    <name>A0A183HPB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9323</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011310">
        <property type="protein sequence ID" value="VDO59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPB3"/>
    <dbReference type="STRING" id="387005.A0A183HPB3"/>
    <dbReference type="WBParaSite" id="OFLC_0000932401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22256" checksum="53CD8998B88D51CA" modified="2016-09-07" version="1">MIKWPNGLALDILEQRLFWADAKVKLIMSCDYWGQHIRLVLRSHERVKHPFSLTVFEERLYWTDWDQEGVLTANKFTGSDFKTVMNGVSGPMTVRVYHELAQPDHPNKCASHECEHICLPKAHLPANKDAHFLLRGRPYTCACMNGFIVSLENENYCVSESGASGGDKSNGSSPFSFSSIFFLLLVSSLAIAVSMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC9</accession>
    <name>A0A183HQC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glyco_transf_64 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012159">
        <property type="protein sequence ID" value="VDO62500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC9"/>
    <dbReference type="STRING" id="387005.A0A183HQC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000969001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000969001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000969001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="6">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO62500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000969001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10918" checksum="7C032594BC4C8BFA" modified="2016-09-07" version="1">MDVKHRLNVAGHDYMFPYFRAETLPSEILFFRVWREQRAKIVGFPARRHSQQGNEILYDSNHTCQLSMILTGAAFIHKVLLNRNDMIQLLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQV0</accession>
    <name>A0A183HQV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012553">
        <property type="protein sequence ID" value="VDO63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000986101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000986101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000986101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000986101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10333" checksum="4286C065D8E494C6" modified="2016-09-07" version="1">MYSKLSPMPSTPSPSTFYRNLWRLTERNKKRKKGGLTNSHSNSDEAVSDHSSASQQQQQQQQSIELSTETRDVLPPKGARKCDYKFQRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRE1</accession>
    <name>A0A183HRE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10052</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012998">
        <property type="protein sequence ID" value="VDO65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRE1"/>
    <dbReference type="STRING" id="387005.A0A183HRE1"/>
    <dbReference type="WBParaSite" id="OFLC_0001005201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001005201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001005201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001005201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16070" checksum="FFAEE599C0454843" modified="2016-09-07" version="1">MNALPITNPLRPLRNLFPTNIMRSFNGPIMDMGIDDVAKHYDIPGTIPIACFQPLLEGKGQAKLTRYYFNSRTRTCDKFVYSGKGGNQVCLLCFFFLFFSHQLSNKYVDNFNYAKKKEKNQKPKTKDQNLYFDNFNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRJ5</accession>
    <name>A0A183HRJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WASH complex subunit strumpellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013134">
        <property type="protein sequence ID" value="VDO65869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRJ5"/>
    <dbReference type="STRING" id="387005.A0A183HRJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001010601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001010601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001010601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001010601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="14131" checksum="34AF84FD5C4F1374" modified="2016-09-07" version="1">MLNNIFAETLSECCELSQLWFREFYLEMTMGRRIQFPIDMSMPWILTDYILTSQEPSLIESIFYQLDLYNDAADYALKKFKKQFLYDEVEAEVNLCFDQFVFKVSDAVFTYYKQLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRM3</accession>
    <name>A0A183HRM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-synt_2c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10133</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013213">
        <property type="protein sequence ID" value="VDO66118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRM3"/>
    <dbReference type="STRING" id="387005.A0A183HRM3"/>
    <dbReference type="WBParaSite" id="OFLC_0001013401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001013401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001013401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-tRNA synthetase class IIc N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001013401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8660" checksum="D07F506166352031" modified="2016-09-07" version="1">MQCESKCRNQFMKVLSCDEVRAAFINFFKDREHTYVHSSSVIPFDDPTLLFANAGMNQTITLPQLEKCKEIKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRN9</accession>
    <name>A0A183HRN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso_dh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013247">
        <property type="protein sequence ID" value="VDO66246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRN9"/>
    <dbReference type="STRING" id="387005.A0A183HRN9"/>
    <dbReference type="WBParaSite" id="OFLC_0001015001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001015001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001015001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO66246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001015001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6138" checksum="D1CDF3BDD8D085F9" modified="2016-09-07" version="1">MILCCADLLQHVRLQKYSVALRSATEAVIAEGKIRTRDLGGNSSTPEFANAIGTYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRV3</accession>
    <name>A0A183HRV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10216</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013368">
        <property type="protein sequence ID" value="VDO66721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRV3"/>
    <dbReference type="STRING" id="387005.A0A183HRV3"/>
    <dbReference type="WBParaSite" id="OFLC_0001021401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001021401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001021401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO66721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001021401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14874" checksum="B71D57A53CFC9766" modified="2016-09-07" version="1">MCDGTTKSEMVSFPVHRIRFCARGQLDSAERECFALSFTQKNATATDGALHQCHVFRCQVPEAAGKALLNFANAFRNNGTVKKVPSPRLCRTPQTSSADEETSSLEGAFSPGGEEDFQFDAFLEMRVRYKNDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSK8</accession>
    <name>A0A183HSK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tim44 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10470</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013981">
        <property type="protein sequence ID" value="VDO68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSK8"/>
    <dbReference type="STRING" id="387005.A0A183HSK8"/>
    <dbReference type="WBParaSite" id="OFLC_0001046901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001046901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001046901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552616" evidence="2">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001046901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10059" checksum="7A53F389515C5669" modified="2016-09-07" version="1">MFQILAKYNIMGLGLGLGVAAMAQMRTNETPSLTPSQALSQPQRFETTNLAGTTATVDSPDRRFAGGTGGGSNAAGGAAGAATGGGQNDLSKVQSFFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTD6</accession>
    <name>A0A183HTD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014690">
        <property type="protein sequence ID" value="VDO71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTD6"/>
    <dbReference type="WBParaSite" id="OFLC_0001074801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001074801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001074801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001074801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3940" checksum="1A62AA8A923E2F79" modified="2016-09-07" version="1">MRSVPQHCNLNGLKYKLLNNIIITIIIINLSKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUH7</accession>
    <name>A0A183HUH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">I/LWEQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11137</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015696">
        <property type="protein sequence ID" value="VDO74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUH7"/>
    <dbReference type="STRING" id="387005.A0A183HUH7"/>
    <dbReference type="WBParaSite" id="OFLC_0001113901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001113901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001113901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001113901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5261" checksum="B75A062C4B89289D" modified="2016-09-07" version="1">MESQVRILELEDKLVRERTHLAQLRKQHYQLAQIVENNNDSADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUY1</accession>
    <name>A0A183HUY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11293</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016145">
        <property type="protein sequence ID" value="VDO75406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUY1"/>
    <dbReference type="WBParaSite" id="OFLC_0001129301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001129301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001129301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001129301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3544" checksum="56E8D244C75293E1" modified="2016-09-07" version="1">MGFGGFDRFPPPRRESRLIWATTTDTLSIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV29</accession>
    <name>A0A183HV29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11343</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016289">
        <property type="protein sequence ID" value="VDO75786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV29"/>
    <dbReference type="WBParaSite" id="OFLC_0001134101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001134101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001134101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001134101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10766" checksum="E129089E2C86226A" modified="2016-09-07" version="1">MDQKYKEVLTHHVYFGHRGNVIIMSSQIVALVVIFTHADVNQHKHKCRRHEIWTECVGCELKCGQSEFVSDSKLINIDSFTNWSLGRSVDNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVD7</accession>
    <name>A0A183HVD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11444</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016523">
        <property type="protein sequence ID" value="VDO76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVD7"/>
    <dbReference type="STRING" id="387005.A0A183HVD7"/>
    <dbReference type="WBParaSite" id="OFLC_0001144901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001144901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001144901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13434">
        <property type="entry name" value="SPFH_SLPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF72">
        <property type="entry name" value="PROTEIN UNC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001144901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10071" checksum="F5D7FBCA838851BE" modified="2016-09-07" version="1">VVSYAVPPQEILSKDSVTVSVDAVVYFRTSDPIASVNNVDDAIYSTKLLAQTTLRNALGMKTLTEMLTEREAIAQLCETILDEGTEHWGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVM0</accession>
    <name>A0A183HVM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016733">
        <property type="protein sequence ID" value="VDO77135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVM0"/>
    <dbReference type="WBParaSite" id="OFLC_0001153201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001153201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001153201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001153201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4964" checksum="28628733EF554DE1" modified="2016-09-07" version="1">MHIMLALSKNCWKNRSVYFPSTNIVACMQLSMERMMRDTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVV5</accession>
    <name>A0A183HVV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017015">
        <property type="protein sequence ID" value="VDO77882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVV5"/>
    <dbReference type="STRING" id="387005.A0A183HVV5"/>
    <dbReference type="WBParaSite" id="OFLC_0001161701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001161701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001161701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001161701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14800" checksum="ED35DB61420B91E2" modified="2016-09-07" version="1">MRKLTPPFIKFEDNSLQYAPSWKEYGIPSNFRPIYVGEAAGRSIFHKASPEFLKRKKETKISKPRAKSRVGPGFCDICTRDCQDLQLVRLFRFPFLLIFCGNIFIIFFNVPFEFLVCPFLIIEIIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWE4</accession>
    <name>A0A183HWE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017566">
        <property type="protein sequence ID" value="VDO79435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWE4"/>
    <dbReference type="STRING" id="387005.A0A183HWE4"/>
    <dbReference type="WBParaSite" id="OFLC_0001180601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001180601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001180601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001180601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10014" checksum="148668909A9F463A" modified="2016-09-07" version="1">MAGIISSANLSFTTNIPEIPIEYTIVDQPEYGVVQCSRGLGQFEICSTFTQNDIDNSRVQYRHSSFAHPLLDTFSFQVFSSKNTTNSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX12</accession>
    <name>A0A183HX12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12026</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018125">
        <property type="protein sequence ID" value="VDO81231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX12"/>
    <dbReference type="WBParaSite" id="OFLC_0001202401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001202401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001202401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001202401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4187" checksum="DF45DF7FDA343E9A" modified="2016-09-07" version="1">MGSLMNLKVNCFVPLSHRENEMLRQKKLLKRLVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX41</accession>
    <name>A0A183HX41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12050</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018201">
        <property type="protein sequence ID" value="VDO81465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX41"/>
    <dbReference type="STRING" id="387005.A0A183HX41"/>
    <dbReference type="WBParaSite" id="OFLC_0001205301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001205301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001205301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO81465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001205301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15775" checksum="F2F5BD72BE765B35" modified="2016-09-07" version="1">IIPKEISKESFWAQTAEEKFANERRQSNTESDSTTSGKSLPKKKVRKPLIIQDEKILQNLAILQGSQKIPLEEWKRILLEIDDRVISSGTMQQLRNALPPSDILQKLQDLAGNKFNEMPEGEQVTSSKYFLSKNEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXU2</accession>
    <name>A0A183HXU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PI3K/PI4K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12299</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018927">
        <property type="protein sequence ID" value="VDO83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXU2"/>
    <dbReference type="STRING" id="387005.A0A183HXU2"/>
    <dbReference type="WBParaSite" id="OFLC_0001230501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001230501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001230501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001230501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17139" checksum="D65D2BA507E4C6B2" modified="2016-09-07" version="1">MIIRSPTFGAVQPALLTHFFETFGPPSSEAFLFAQQNFVRSCAGYSLACYFLQVKDRHNGNILLDSEGHLIHIDFGYILSISPKNLGFETSPFKLTQELVDVMGGVNSDMFGYYKILILKGLLATRKHYEQIVSIVEIMINGLHLFLYFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY22</accession>
    <name>A0A183HY22_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS12384</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01039833">
        <property type="protein sequence ID" value="VDP11202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY22"/>
    <dbReference type="STRING" id="387005.A0A183HY22"/>
    <dbReference type="WBParaSite" id="OFLC_0001238501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001238501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001238501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000002">
        <property type="entry name" value="Alkyl hydroperoxide reductase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="100"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP11202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001238501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35156" checksum="4D532292C11F100C" modified="2016-09-07" version="1">MFVTKITTALNRPPQPGHITSNVTSRTAQFPQNLTSTHLILAKFRLEGWNMLIFCPLYATVLSKIVEQTDDGEAAASPFRQILTSRFCTSSVALAGVRPLGPKNKAPDFSGTAVVNGDFKTISMKDYKGKWLIIFFYPLDLISVMTNAVAQWRCFSLWRDDPCTFVCPTEIIAFNDRCSEFRKLNAELIACSCDSHFSHLAWTQTPRSEGGLGDMQIPVLADFNKDIANAFGVLDHEAGISYRGLFLIDPNGEIRHSLVNDLPVGRSVDEALRTLKAFQFVEKHGEVCPANWSDDKPTIKPGIKESKEYFNKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYG2</accession>
    <name>A0A183HYG2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12524</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039859">
        <property type="protein sequence ID" value="VDP11513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYG2"/>
    <dbReference type="STRING" id="387005.A0A183HYG2"/>
    <dbReference type="WBParaSite" id="OFLC_0001252501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001252501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001252501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514017" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP11513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001252501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36818" checksum="EA5E82286097AA90" modified="2016-09-07" version="1">MRRVICALVLWAYLFVEGDEHDHLYREGEEIVLWMNTVGPYSNRQETYAYFSLPFCRGPKHSISHYHETLGEALLGVELDYSGLDIKFKENVEKVEFCKKTLSEEDYKQFVYAVRNNYWYQMYLDELPMYGMVGEIDSSITPPNYRLFTHKKLEIGYNGKQIVDINVTSDIRVTLTPGASISFTYEVVWKTSDIDFDKRFEKYLDPTFFQHRIHWFSIFNSFMMVIFLVGLVWMILMRTLKKDYARYQKDEDLDDMERDLGDEYGWKQVHGDVFRTPSFPMLFSSLVGTGCHVFTVVIITIILAIIGEFYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYW9</accession>
    <name>A0A183HYW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Palmitoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039902">
        <property type="protein sequence ID" value="VDP11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYW9"/>
    <dbReference type="STRING" id="387005.A0A183HYW9"/>
    <dbReference type="WBParaSite" id="OFLC_0001268201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001268201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001268201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001268201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15110" checksum="BAA18B8B2EC6A4FD" modified="2016-09-07" version="1">MIFRRDLCGIFCALLTYLAMMYADYVVIVWLITPTFMESLWGVLHAVMFNTLLFFAFASHLRAMVTDPGIVPINRKGMKLLRCNKNRFLKLLSDSESTSTDTDVELIEEKNKFMVGLPFFFLQYLSLYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYX1</accession>
    <name>A0A183HYX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12683</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039903">
        <property type="protein sequence ID" value="VDP11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYX1"/>
    <dbReference type="STRING" id="387005.A0A183HYX1"/>
    <dbReference type="WBParaSite" id="OFLC_0001268401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001268401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001268401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF4">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="51"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001268401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32406" checksum="72436EDDFE5C0A62" modified="2016-09-07" version="1">MDKYGGAEFRLPPFEDIWKPAFRIPFISYFLLFQTIAYCIRTYAWKSYSGFKQYRLHNLTLCFMHSSITGVCSFVFSITHQQIMLEDTIHWYSPWAAQLPILSIAYFVCDTMDMLRHEISRWTIELLFHHIASAFVFTVPVLSRKFIPYAYWALLMEVNSIFLHLRSLMQITGYSILKQSLFRLIRFANIITFVLFRFAVQAWQINWAWMNYHRSHIFYMGIAFIGGGFFLIVNAILFVRVLASDGYLGEFGRKHTAIDRFIFFFSCFFPFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZM3</accession>
    <name>A0A183HZM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2877 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12935</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039981">
        <property type="protein sequence ID" value="VDP12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZM3"/>
    <dbReference type="STRING" id="387005.A0A183HZM3"/>
    <dbReference type="WBParaSite" id="OFLC_0001293601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001293601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001293601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001293601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24715" checksum="FE842CD0E0B4C56F" modified="2016-09-07" version="1">MVNLYGIGNGKKIKLSDDLLKSVFDAYKTRSNAGDLVIMSLLLLTDEKAQENIRQTLENDFFKEKFISSLNTSDILYAAKLSDWMIRNTEAKNWSGMRNVFYVLFATLFWPDYRIRKGANDIVRKCVVEKGNAFCVAFLDCLFLYVTSGLAQEIWKRVAVMQDEENERILDNKLIAAALHEVMIPFNAAEENFDLGIGVLTSGLLMSCSFQLSKFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZS2</accession>
    <name>A0A183HZS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040000">
        <property type="protein sequence ID" value="VDP12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZS2"/>
    <dbReference type="WBParaSite" id="OFLC_0001298501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001298501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001298501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001298501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10576" checksum="6E0562F47752030A" modified="2016-09-07" version="1">MSMKLLKEAIKLTNADDRIRSMETVRKSVRPSKAERDRQQLTAVATTSEYDPESDDIIINSNMQRRNILNYNGKKTAKVIPVCTIAISYLMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0G3</accession>
    <name>A0A183I0G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microtubule-associated protein futsch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13225</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040097">
        <property type="protein sequence ID" value="VDP13214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0G3"/>
    <dbReference type="STRING" id="387005.A0A183I0G3"/>
    <dbReference type="WBParaSite" id="OFLC_0001322601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001322601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001322601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001322601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="888" mass="100354" checksum="CCF4BF115CC58783" modified="2016-09-07" version="1">MLMQAIETSALAEQEAEPPVKSETDKVEVPLTTKAEALVEEEKTAVDVEVEASNDFKEVETVLEEEAPPAEEGTAVSVEALRKDDETKEVPSEQEPDAPKAKSEEQENQELMEETQPEVEQAQDELKSAEPVEVTDVIQEIVVEQLQSLGANESEATIEEFSEGDGEATNKEEDVDNEQNEADNVESSNEEEQSKVWASETVQMTVEDEQKEEENSFASALQPEEKSEAGQSDGHNSRSSSSKYEETNDAEMATPLTKQEFAFDEEKPSRKSSIVEDKIPSRKTSTMEEVPSRKVSEIPSRKVSEVPSRKVSEVPSRKVSEVPSRKVSTTEGKAFSRTASVVKDEELPSRKASEVTEKKTSSRKTSAVQEAKAPSRKTSEIEVPSRKTSAIEETKVTSRKPSAAQEKAPSRKISLEVEEKAPSRKISKMASLEETNESVTEKAKTEANDANVEPEVEAAVAEPESVADENKVEGGEAETMVEIQTEELKNEVLLEDAFGEVKKTPLAEVTNKDQKFATVNEREFSPSRKFTSPPGRHSPSSVRKRQERSPSPVRRNATYKSYDQDFRLKFSSNHQDTYRQKGPPPRMPSYLSFSSYTPVEKTTYSPISPWVQNNAQKYRNDYTAVSTYKPPSTYTSIFDDIVSSGPFSTSLYSTSRLLERSRSRSRELRNALRSKRSTSNYYRYTSNYATPPFRTRDYSTPPLSSVYHPSSRSGSFISFMEYTGQKQYELARSSSRLSAFDGLSRTSSRSNIDMFYDKERLSRVDSYVRDLNRNIEYGLPSTYMKYRSPSRPYLPQDYTPINGYRVCCLKFLSHYSYQQLKTSRIADLQRSLSRERLARERMNAKYKTLSHKLEQASRQMDLLRSNFYSSIRGGTGIYSVYSHNYPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I104</accession>
    <name>A0A183I104_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040188">
        <property type="protein sequence ID" value="VDP13694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I104"/>
    <dbReference type="WBParaSite" id="OFLC_0001341701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001341701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001341701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001341701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8715" checksum="6F6896EE01A48700" modified="2016-09-07" version="1">MVTPSEYLREQTCPPCSVSHLRGLTRLHVSPDRKAENDSNFLNEAIYDAVLHAEGRDAIWPEFSADIIDSNIERNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1C0</accession>
    <name>A0A183I1C0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">OFLC_LOCUS13532</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040251">
        <property type="protein sequence ID" value="VDP14002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1C0"/>
    <dbReference type="STRING" id="387005.A0A183I1C0"/>
    <dbReference type="WBParaSite" id="OFLC_0001353301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001353301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001353301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF14">
        <property type="entry name" value="INNEXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP14002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001353301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42588" checksum="726166941CB194DD" modified="2016-09-07" version="1">MVVTAVLSMVRYIGDIDDWDFVDRLHSYFTVNILIAFSILVSFKQFGGKPVECLVPDIFSGSWEQYAENYCWAQDTYYIPIREVVAGIPTTEKKQRRISYYQWVPFFLLVEAACFRLPSLVWKYMAGHSGIKLHEIVKLSSDPNNIKPEIKKANIKSLTLHLHGALRFHRRLRKKQIHPHRYLRLFNIPYTASFVTYTYVLTKLLYLINACVQLLIMNRFLETDRYNWYGLGAALDLLNGTTWEQSGMFPRVSLCDFDVRVMGNIQEHTIQCVLVINIFNEKIFIFLWFWYLALIIFTTGSLIFWITVCLVPCPNRNFIIRHLEMSEFPFDAQGEYAKLEIKVLTHLSFFNSLLGELFLVSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1E8</accession>
    <name>A0A183I1E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS13560</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01040266">
        <property type="protein sequence ID" value="VDP14073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1E8"/>
    <dbReference type="STRING" id="387005.A0A183I1E8"/>
    <dbReference type="WBParaSite" id="OFLC_0001356101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001356101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001356101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="245"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="454"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDP14073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001356101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="647" mass="72789" checksum="287FCED70DE849E2" modified="2016-09-07" version="1">MVVVADVADEVGTSSGRDSSDVLLALQKYQARRRQIEEEEARRRREGFLSDEEDASMDDFFIPARQRKKEKMHRRALLKQVLHAKGGAPDVDTEKEDLEFLERKRRKKEEERKAEEAKKSLLEKHNELLEAEIGDRNSEKKKREEEQKLLESVAPGTALMAVAEIARGVKYEESIKTSWHPPRHILAVSDEEHTAMRRKKGILVDGDDVPPPIGSFIEMKFPPPVIKALRDKKIICPTVIQMQGIPVALSGRDMIGIASTGSGKTLTFALPLIMFCLEQEVSLPFRHGEGPYGLIIVPSRELAKQIHDVIERLFENICDGTKFPRLRVGLCIGGLPISEQARVFERGVHVCVATPGRLSDLLSKKIFNLQVCRYLVLDEADRMLDMGFEEEIRTIFSFFKGQRQTLLFSATMPRKIQNFARSALVRAVIVNVGRAGAASLNVVQEIEYVRADEKLIRILDCLQKTAPRVLIFAEKKSDVDNIYEYLLVKGVDVASLHGGKDQKDRHTGVDAFRRGEKDVLVATDVASKGLDFENIQHVINFDMPEDIENYVHRIGRTGRSGRKGMATTFINRRADMSVLQDLRALLLEAGQELPLFLRDMGGPELEQSSDSTNADDKGCAYCSGLGHRITNCPKLENVQTKVGCFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1X4</accession>
    <name>A0A183I1X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13736</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040365">
        <property type="protein sequence ID" value="VDP14526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1X4"/>
    <dbReference type="STRING" id="387005.A0A183I1X4"/>
    <dbReference type="WBParaSite" id="OFLC_0001373701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001373701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001373701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF1">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552727" evidence="1">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin" evidence="2">
        <location>
            <begin position="259"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001373701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="38631" checksum="089E137B135E9596" modified="2016-09-07" version="1">MIMRIVSILLIAASITHADISDRPIKIRLPPQNRKPNFMKEMAPPRPMPLEPATSFNRPQKLNPGIRPSLTPAAQLPVIPPAKQQFVPRPITTPPPPPPINIPPDVQNQLIKFFGLDSFGIPGLTGNHPDGFAGAIQELRAAGIPVQGTSGSGDAAVAYSTDAEAEAAAQTASRSGIRRQQNTAQRVLSGVAAALGGGGGRGPVHAGLPRIPGIPLLPSGIPRNEQGSEFGPVRYSIGYAFRGGNKDAMLQLHSSETPDAQPFWIYKLGPEGTDPFGNPQYEWAVVSNWVKYPVTVLVRDPDKFKAKYEQEVLRWLEDQGFINGFIRAFNMLQPASYSSCQYADSTFEVFGPSKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3W9</accession>
    <name>A0A183I3W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SKIP_SNW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040850">
        <property type="protein sequence ID" value="VDP17015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3W9"/>
    <dbReference type="STRING" id="387005.A0A183I3W9"/>
    <dbReference type="WBParaSite" id="OFLC_0001443901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001443901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001443901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="2">
        <location>
            <begin position="84"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP17015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001443901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28291" checksum="D49F255A2C547F87" modified="2016-09-07" version="1">MERFPKYLWQAIKHLRHECDAEGKLRNDAIARSGHSKDKIICTRLVDVKPKVFEEEGELLQRPNEETITQQTEATRLALEKITSTKVASGGHNSGAKQRIIRMAEVQQDPMESPKFKINRKIPHAPPSPPASVISSISPLKTTVKEQVDWKIPPCISNWKNPKGFTIALDKRLVVDGRGLQQVRINEIFANLAESSYFAEHIAREVSQEARECNQVRRNRLDEYRRERNIARNNPDKLDRFKKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Y5</accession>
    <name>A0A183I4Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14797</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041210">
        <property type="protein sequence ID" value="VDP18843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4Y5"/>
    <dbReference type="WBParaSite" id="OFLC_0001480801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001480801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001480801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="92"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP18843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001480801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24152" checksum="CE711C597DA774DC" modified="2016-09-07" version="1">MXXXXTRIAYREELEIGIRNRLLILLQTKKRKRKLLSATDEAENTTPEKMLRNKKLEEEIESITDNFIPDIMPTRVAYREELEIGIRNRLLILLQGPIGCGKTSLVRDVAHSMKLPYRAIQMGEQIDSKTLFGTFHCLDVPGEFCWKKSTFTKYILEKGIILLEDIDCASVDLISQIIDLCSNREARVTSGETIRMHDEAYIITTMSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I501</accession>
    <name>A0A183I501_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS14813</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01041235">
        <property type="protein sequence ID" value="VDP18939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I501"/>
    <dbReference type="STRING" id="387005.A0A183I501"/>
    <dbReference type="WBParaSite" id="OFLC_0001482401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001482401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001482401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="2-oxoglutarate dehydrogenase E1 component N-terminal" evidence="17">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="16">
        <location>
            <begin position="258"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDP18939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001482401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68320" checksum="5E76959DDB5C59C4" modified="2016-09-07" version="1">MLRRINFSKSKISLTLLRRQEFSNFALSTSKLSRKQCIISGLRHKFSAATSEEPFMNGTSTVYIEQMYEAWRQSPASVHPSWNAYFQNVERSLPPGQAYSAPPKGLVSASTAISPALEVGNLLNISGQIIDEHLKVQLLIRSYQTRGHNIANLDPLGINNVGLTDITPAELDPAFYGLTDADMDKEFILPMSTFIGGDKKSLKLKDIISRLKAIYCSHTGIEYMHLTNFEQLEWVRKRFENPCASELTHEQKKTLFKRLIRSTKFEEFLAKKWPSEKRFGLEGCEVLIPAAKQVIDASSATGIDSVVIGMPHRGRLNILANVCRQPLSVILSQFSTLEPADEGSGDVKYHLGICLERFNRVSGRKIKIAVVANPSHLEAVDPIVLGKVRAESFYNGDKNGDRTMAILLHGDAAFSGQGVVMETFNLNDLKAYTTHGTIHFVVNNQIGFTTDPRCSRSSPYCTDIGRVVGCPIFHVNSDDPEAVMHVCNVAADWRRTFKKDVIIDLVCYRRYGHNELDEPMFTQPLMYQRVKETKPVLAIYQKQILAENIVNEQYVEDEVTKYNDVLEDAYQEAQKVTYLRHRDWIDSPWDTFFKKRDPLKIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I516</accession>
    <name>A0A183I516_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Caspase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS14828</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041254">
        <property type="protein sequence ID" value="VDP19061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I516"/>
    <dbReference type="STRING" id="387005.A0A183I516"/>
    <dbReference type="WBParaSite" id="OFLC_0001483901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001483901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001483901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="59"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP19061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001483901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31411" checksum="23971F9A51769293" modified="2016-09-07" version="1">MEDTAMTMTAERRRLLDKHLDIWTRYLQLDDVIVFLLANSIFNEHIVDIIKIYANFSSPRGVALIINNRYFLDMPERIGTDIDEINLNNLFRQLNYTVSVYRNLCAKEMLNAIRDFSKRPEHRLLDSCVICVLTHGEHGELYGTDDKAVSVLEFVSCLNARNCPALAHKPKLFFLQACRGQQYDHGFGTEFDGSDGYFDRWFTCATPQSQKNLPVEKKTKSPIEADILVSYATTPGYVSWRNSMKGSWFIQSICEVFAKHAKSTDILSMLTLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5B6</accession>
    <name>A0A183I5B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14928</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041368">
        <property type="protein sequence ID" value="VDP19625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5B6"/>
    <dbReference type="STRING" id="387005.A0A183I5B6"/>
    <dbReference type="WBParaSite" id="OFLC_0001493901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001493901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001493901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001493901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41574" checksum="5681FAE5B669C85F" modified="2016-09-07" version="1">NLSPIYYYFQARIKTGGAPYSEPLSLIPDRSPSAVPSEISGDPATSVSVVPTPSPCSSDSFDLGQILASYGYVPCATFKPGTTVVHITSTVGLTANRSTNHHRLRGGGSGLNNSNFRGSNSRARGGFVYNQRVCTSDHRDFSTNSNYQHGGNRRNNKNHDDAHRDGYRDRNNVPPLAFVRPRGRQNRFNNFYSSRNQRMYMIIIDAVRSRTPVESPKNNQNDNIQQRYDYDQSSGRNVQTKQQRRKQRDTPLPGISSGNNKSVMCPPIICLPPEEGKKSEQQCCSKTASDDDSKLERSNSRKTVDTEYSFEEGAFPCLSEKISPVVEIKESKSRNKPTFSSVAAGKREEKKEAKERKSYAQTLKQNNGLLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5U4</accession>
    <name>A0A183I5U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041620">
        <property type="protein sequence ID" value="VDP20413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5U4"/>
    <dbReference type="WBParaSite" id="OFLC_0001511701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001511701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001511701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001511701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10368" checksum="7FBC7EC5FA123679" modified="2016-09-07" version="1">MLYHKQINREESIGEGNVNIYQMLFCATSSHECACAITHSKHKLKRNLETEEGPGVLPDDTHPAGCVIRGTDGNIGGNERTELWWPNECKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5X3</accession>
    <name>A0A183I5X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15135</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041663">
        <property type="protein sequence ID" value="VDP20541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5X3"/>
    <dbReference type="STRING" id="387005.A0A183I5X3"/>
    <dbReference type="WBParaSite" id="OFLC_0001514601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001514601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001514601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001514601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14403" checksum="FC6A66CFC9788FC0" modified="2016-09-07" version="1">MLSKEDKTKLLEKCIEIDKIIKKSINLIPIGNWQFDDETMENLREQKHRIVDENLTNEQKQRLSKTSKHRLAREIGVNCRTVTDVLDWLAKNHSNTKPIKVRIFCFICFISITFAFFHTAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I718</accession>
    <name>A0A183I718_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS15530</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042309">
        <property type="protein sequence ID" value="VDP22387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I718"/>
    <dbReference type="STRING" id="387005.A0A183I718"/>
    <dbReference type="WBParaSite" id="OFLC_0001554301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001554301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001554301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP22387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001554301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18434" checksum="19C32D25F0AF97FA" modified="2016-09-07" version="1">MLQRVYRLFNDDESTDVENLSNPSVNNTSQNQFDEDSSLSWDLRVQYFLGCLFLSVICSLAGSALLFTWRVTGFTVMVSLGSILSLFGTCFLMGPLRQLQKMFEQGRFLASLIYLLSIAFTLIAGLVFSNPPLALVFVVGQYIAVAWYSITYIPFLRYDFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I890</accession>
    <name>A0A183I890_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15952</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043351">
        <property type="protein sequence ID" value="VDP25289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I890"/>
    <dbReference type="STRING" id="387005.A0A183I890"/>
    <dbReference type="WBParaSite" id="OFLC_0001596501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001596501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001596501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="229"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP25289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001596501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53166" checksum="8EC3372EB7BAE089" modified="2016-09-07" version="1">MIEDHSNTITTLKKYTDRKSRNKNLAKDFCRESRNQDSALTMDTDESCAYTQIFLKEQSKNDHMTLIITDKKSVSSMIKEKSDNELIIIVNNKMESSASIQNDVGILYLNIRNPKNFQNSLSSHLNGQKTAMIRFELNSNFPLRYLTEVLLHLTETITQSRHTYIFSSKPGYGRANAFALGFAKSLSAELYPKVRYEWNFILQKIPNLKNFIKNLSKKSLHMNEENLKERWLITGGLGGIGWQMAKFIAFNRNVSHLILLGRKQPNEMQRQEIRQIRDRVNVDVRAVSVDLTSKMQMKEFFKKLQITLTSIIHSAGCLHDALASRQNLSTFRLVTEAKCDGLLILEKLCRSHPIKHFIVNSSVSAVIGNQGQCNYSAANAFIDEIMLERRTKRLPATIINWGNWLETGMAVKANKILNKMGFIGLKTKNAMNYLQIAIDQAPIRMIVVRLDIRKIANYRPDLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8E0</accession>
    <name>A0A183I8E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein transport protein SEC31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043559">
        <property type="protein sequence ID" value="VDP25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8E0"/>
    <dbReference type="STRING" id="387005.A0A183I8E0"/>
    <dbReference type="WBParaSite" id="OFLC_0001601501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001601501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001601501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001601501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12173" checksum="B413722496EFE155" modified="2016-09-07" version="1">MQLWDISAKLDMNPYCSQLQQNNYSGIPVYMTNGYDQSKIGYGNGNSAANITQKQQQQQQNVALNQSWGQQWPYYLSAPHTSNIITPINQYNRPYQQMFVLIDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8Q2</accession>
    <name>A0A183I8Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16114</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01044138">
        <property type="protein sequence ID" value="VDP27390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8Q2"/>
    <dbReference type="STRING" id="387005.A0A183I8Q2"/>
    <dbReference type="WBParaSite" id="OFLC_0001612701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001612701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001612701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP27390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001612701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3680" checksum="F5632ADD098B252F" modified="2016-09-07" version="1">MTCHFTSDGILQIKAPYNPPQEAITADTEIPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UF41</accession>
    <name>A0A3P7UF41_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01000811">
        <property type="protein sequence ID" value="VDO30249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UF41"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO30249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="219" mass="24390" checksum="A286EA58A1E7E720" modified="2019-02-13" version="1">MYIFQEQAIERLLRFQDVIVQAPTGSGKTLAYILPVFTILWKKKKIWPENEIGAIIIVPSRELAKQVGAVCKLFADTLPLSMRIMIGGKKAKCNLKTVHSSNAAVIIATPGRLQSLISSNSDFKKALKALEILIIDEADRYTDSSFKASMTEILESLPKQRRTGLFSATQAKEMEEIVKFGLRNPTQITITNCGEVLDSIDSVKAISPNTLNNFYMVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V341</accession>
    <name>A0A3P7V341_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002763">
        <property type="protein sequence ID" value="VDO38129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V341"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="183"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="536" mass="60982" checksum="EE1B8F1382EFD125" modified="2019-02-13" version="1">MFQVGDPVVGPYYLKNILYIGKNPVDGAVELHVRENVLCSHWTNLKLKMITEVEKWILDIVKCIMPKNELLLYSVKSLNAGGSVWIRQGTACAWSSGWMFLDEHKLYYALDSCAILFELDVRKFVGMKNTLSKVDWCASIVGSMKGPFLLLQEGGSLFVQAEYDSATLTWIDLLNHQMECSGYRLEDSKLTSDDVPVIVDKCIKFISTYGLLQPGLYRRNGPKIEVRSLLAEFRKDPVNVHLLPGSDDMTNVVADVLRSFFRQLDSPLIPYHIQDRLFAVASLKDPTRLDEYHEILMGLPRIRIQTLRRILDHLKDVTELANANLATIENVAKVFGPTLFSVEQDNGVDSSFAVTIQQVNLVKDFLTYYASIFRISAREMIIKSKINMLQEKSNQTKARADGFLVPVHILEKDNHTFNVQSSSNAEQVCDAARNRPAVRSKIDVDNFALFEEIKCGQLERRVNPLEKMSSMITGRWLDWEPAECFLLFKRDPIPYSFRLSYPFADDVRIAEQGTKSFNIGHLKLEGGLVAYYNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WIN5</accession>
    <name>A0A3P7WIN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006453">
        <property type="protein sequence ID" value="VDO47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WIN5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="266" mass="29939" checksum="ACA761B7D0329483" modified="2019-02-13" version="1" fragment="single">MHSQVSFNEKWGDIARAIGLTDGVAVAEHAIKVLYMRQSSSVLFRYLSKYEQSDLVGEVDDADSDLLSSRSRSKGFSSLATADCPISMGQRQASEYFRLRPEKKEAEYDRIVKSLLSGLPNEVDFAVNVCTLLSHPGPRVLRLVAAPQIITLLVAHLAIFPDGDRAFYDLYKSWELVSGHNFIEFWSAAGITDDEVLKLIPHIIPSRISEEESNIFCGLDTEFQPRNVVSWRIQQVLSIIRNLSFEVINKAILAASWPLLKYVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XFL0</accession>
    <name>A0A3P7XFL0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015209">
        <property type="protein sequence ID" value="VDO72616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XFL0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO72616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="132" mass="15695" checksum="089322828CBFC0DE" modified="2019-02-13" version="1">MKSILSPDHVEFTARLEQQEPVSDNFICLDSFDLESILGPDSDEQKYKCGYPGCKWTIPDIKDYIEHIRIHNSRGVNMCHWYGCKKSFRTLVKLRKHQRLHQFKFECENCWRLFNNKHACKAHKKCCSKNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZE78</accession>
    <name>A0A3P7ZE78_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006810">
        <property type="protein sequence ID" value="VDO48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZE78"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000223">
        <property type="entry name" value="Goosecoid homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051440">
        <property type="entry name" value="Goosecoid-like_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="155" mass="18047" checksum="52365D57CCF89A12" modified="2019-02-13" version="1">MKFCTSDPGFPYINSGFITSFHPFHYGGKRKRRHRTIFSEEQLQILENAFQGTHYPDVMLREKLAVQCDLKEERVEVWFKNRRAKDRKQKREIDVKDGTGQKISASDESDYEVSDDDDDCTKVKKHRLPSNNEASTDNAHHIKVADIKKESKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AUT1</accession>
    <name>A0A3P8AUT1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041085">
        <property type="protein sequence ID" value="VDP18242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AUT1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06080">
        <property type="entry name" value="PWWP_MUM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035504">
        <property type="entry name" value="MUM1-like_PWWP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42569" checksum="E25E897ACA1022BF" modified="2019-02-13" version="1">MIAFFFLADLKAGDVVWAPYRRFPEWPALVRCVYPKKVTYTFLPIDESSNLKSSIFSCPPQKLRLLTGNEPLPAGAKNDMKEAYKAALEILKKSGLLSADHQMSEELSTFKASEINKQSVLGDLVRKTKKDSDAASSGDTASNASAPHVWGIGEVVWLSMPNHSEWPVVIRELKKKFAMVDAFPLKFNCKPERYPLSACQKFELTGKNLEAAIRKERNCELRMALQSVMKYFKRREQMNSMEKSDTEDNDGAKIEVESDAQQGRKRHMDKSSSPTAKRPKFSDVMKDLETELSEKLENLSKGDLAWINRARSGRIVKWPILVLKVDNINKSCVCTELPLDDMSANAEWCLNSEKTRVVQLKNIYLYDTVEAKVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B7X0</accession>
    <name>A0A3P8B7X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041117">
        <property type="protein sequence ID" value="VDP18381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4Q3"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="238" mass="26571" checksum="060E495B393A1CC0" modified="2026-01-28" version="1">MPGKKVLNITHVIFDLDGLLIDTEPCYTETHTFAMKQYGKKFTLDLKSLTMGIKHEAAIKILLNKIGLADKVSVEEYDKFYRPALLEKLPHCPKMPGALRLVQHFHSHSIPMAICSGSSNYSFKLKTMNHKDLTDLIPVQVKCGSDPEIEEGKPSAEAYLVTMKRFRNPPLDPSNVLVFEDAPNGVLAAIRAGMNVVMVPDLSYVQVPDEGKEQIVEVLESLEDFRPESVGLPAFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BLC6</accession>
    <name>A0A3P8BLC6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015522">
        <property type="protein sequence ID" value="VDO73585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BLC6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO73585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="126" mass="14729" checksum="2D43850A00A9A4C4" modified="2019-02-13" version="1">MQPDCTGRQLFDTVCRIIGLREIWFFGLQFVNKKGIPCWLQMDKKINKQEVPKQKDGSIHLIFLVKFYPEDVEEELIQDITRHLFFLQIKQSILSMQLYCSAEASVLLASYAVQAIVSLYYTCRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY11</accession>
    <name>A0A183GY11_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS121</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01000029">
        <property type="protein sequence ID" value="VDO24620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY11"/>
    <dbReference type="STRING" id="387005.A0A183GY11"/>
    <dbReference type="WBParaSite" id="OFLC_0000012001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000012001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000012001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514010" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="149"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO24620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000012001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55879" checksum="9BCE7E7D5CD4A5C3" modified="2016-09-07" version="1">MLLSVFLLILFSLCQISPRKNSLKPFRASDRKIVPTPNQGPYYAQPEQIALSYGGNVSSMWITWLTYNDTFSSIVEYGIDDLRWSVKGSSTLFIDGGKQRSRRYIHRILLTSLKPGTIYQYHVGSEYGWSSLYRFKAMRELTNDEYVYAVYGDLGVVNARSLGKIQQQAQRSLIDAVLHIGDIAYNLDTDEGQYGDQFGRQIEPVAAYVPYMMVVGNHEQAYNFSHYVNRYTMPNSEHNFFYSFDLGAAHFIAISTEFYYFTEYGSAQITNQWKWLTEDLKRASRNRDKYPWIITMGHRPMYCSNYDSDDCTKYESLVSHINFHLPVTVRKTVNIIPIRSGMPGTHNFGLEKLFYTYGVDLEIWAHEHSYERMWPLYNRTVYNGTNEPYVDPPAPVHIISGSAGCQEYTDPFVPQPPPWSAFRSSNYGFGRMHIFNGTHLYFEQVSASKDETEDSFWLIKHKHGPYTLEHHKKLKQFGIYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ01</accession>
    <name>A0A183GZ01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vinculin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS461</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000152">
        <property type="protein sequence ID" value="VDO25874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ01"/>
    <dbReference type="STRING" id="387005.A0A183GZ01"/>
    <dbReference type="WBParaSite" id="OFLC_0000046001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000046001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000046001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO25874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000046001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53779" checksum="3868193D83392A01" modified="2016-09-07" version="1">MSIEWCYFPSGRSYSQHLRSYKVNSGSTMVSMASVQAEMNIDGVKTRTVEQLIAPLIQQVTSLMNPNSMHSLKRSGKSGAVLVAAIEQTVRNFVEIGRSAIAECPAAVGNALKQLSEALQDVEHAGVEMVNTGHDFVEETSNTDRRARAIRAARNLLSAVARMLIMADMVDVRVMLLQVAKAQDIMDLIVTAESKQELSELFASLNSCLEQLDESIRRRILELRNPAEQDDMQAARAWLKLNSIIMYTSSTVIDAIMAYIRHPEVDQVRLNRDFAHAQMSLALQTMADILQGCAVNRDICLSNYGRVGDLMRQLDHFQARAYMEPSSYKDHLHRPELEGLLEKIVSGVAAIADSENTRDERKKRIVDECNNLRQALQDLLAEYEKNCGRAEPSEDLDLAMVHLGHKAKDLRRHLRRAIVDHVSDAFLDTITPLMMLIESAQRHDERTTVENGKRFQEHANKLLQVCFTVYLDICDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZA8</accession>
    <name>A0A183GZA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thyroid adenoma-associated protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS568</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000198">
        <property type="protein sequence ID" value="VDO26252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZA8"/>
    <dbReference type="STRING" id="387005.A0A183GZA8"/>
    <dbReference type="WBParaSite" id="OFLC_0000056701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000056701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000056701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000056701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="613" mass="71174" checksum="CD66058162FF7F4B" modified="2016-09-07" version="1">MTRKRKSGLGVAENCYGKRTGDHDSNALNYAMNNAWNSEFMKDFEKRYGHVECNEKWKKRNLEQRLNSSAPDFCEKDELAADTEEFEQSMEYPSELVEYMKQVACIIRHDPSVSGDLQKKCMEECQGSEISLCKYSEPCFLIDEIFNGCRDAAKQWMFKIMQSRKETSLHLLCMPWTCHTLETLLSSLSNALDIEIADYWVDLVLENWIQLISDRNASHFIRTLTYHLTGLRRKRSGETEKFLAKNVLSKKVQISPAAKESFKRIASMALDYASINAMLDNESVSLVLQDVIECDSVFQTGYLRKFVEVACRDPDSVLKQWKEKQASHLWDIIVQKVDEDLRQSLYHSVLEGKLFDLSLHMFANFPLQKYMLSVKSNELVINVFDELMAHFMDICAECKWRIIIVLIQMARTRDEIVIVKKLRKYFKCDSKSARSAFIPCVFTLTCRTSIQCKFPDSGITGTFDIMKGQLYGSLILQELVNYEHNKTVIMSMKSLPDTAIFEMAQDKKGSFLLQAVFKSSTVSRTDKQLIARPLKLKWYELITNNVSSHVFDVLWTNDLYNIMEKEKLMDALSKTVIENHCKTLRLMCMKLDLRKFREQRKKWLKDAGIKSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZX9</accession>
    <name>A0A183GZX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS789</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000307">
        <property type="protein sequence ID" value="VDO27077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000078801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000078801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000078801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000078801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="4220" checksum="4F82CF4E45D27652" modified="2016-09-07" version="1">MSPRGLRKYLTLGKIYVLMNITIVIPESIELFIKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZZ6</accession>
    <name>A0A183GZZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCR1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS806</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000317">
        <property type="protein sequence ID" value="VDO27149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZZ6"/>
    <dbReference type="STRING" id="387005.A0A183GZZ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000080501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000080501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000080501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000080501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26325" checksum="F31492E048D437DB" modified="2016-09-07" version="1">MEIVKETEKTTEQQRSVLPEIVQQKQISTINLLTHLDDTGSSNERMINHNNISGFYSNDSINQLSTTGPCSSQNIMSGGISREQNEDGDCGPWRQVAFRKEASLSGPTKMDKLKTQYDHLLMISEKGYVGKLYSEWMYVPEGGPFDDRVKNIRQFIQELENILNEPNSTWRDYFNMKKYLQILIDNVMVDFNALSGQAASTHLPSSITFSSSRSTVSDVGRDNADISIRPNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0N1</accession>
    <name>A0A183H0N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-mRNA-splicing factor SYF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS1041</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000443">
        <property type="protein sequence ID" value="VDO28005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0N1"/>
    <dbReference type="STRING" id="387005.A0A183H0N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000104001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000104001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000104001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001071">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="8">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="79"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO28005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000104001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="63149" checksum="3E33B657F2DB8AEE" modified="2016-09-07" version="1">MDEIDNEDTATDEEQQLELELLFARFEHLMDRRPLLLNSVLLRQNPHNAYEWLNRVQLYEGNKKKQIETYEEAVRTVQPKLQTGKLSNIWISFAKFYEQEDMLNEARLIFEKGLKSEYTKVDDLASVWCEYVEFELRHRNPEHARKLMQRATAMPPRRTHYFDETEPVQNRLYKSLKIWSLYADIEEAFGTQENCQAVYERIIDLRIATPQIIVNYAKFLEENNYFENAFKAYEKGIALFRWPIVNEIWTIYLVKFLKRYGGKKLERARDLFEQCLENCPPKFAMKLYLLYAKLEEEYGLPRHAMNIYNRATTAVEKHEMYSMFNIYIKKATNMYGLTFTRPIFEHAIEVLPEDQSREMSIRFAQMERTLGEIDRARAIYAHCSEICDPRVHGIFWEIWKEFEVKHGNEDTVREMLRIKRSVQATYNTNVNIMSAQMLSTAAGAVTGTIIHEPSTAGDSMAMLEARAQKIAEEETGGAKLAVGGTGIKFVRGAVNVIESNVTENPEEIDIGDDDGDDVQKNLDDVETKAIPAGVLGSLAKKSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H220</accession>
    <name>A0A183H220_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1530</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000734">
        <property type="protein sequence ID" value="VDO29878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H220"/>
    <dbReference type="STRING" id="387005.A0A183H220"/>
    <dbReference type="WBParaSite" id="OFLC_0000152901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000152901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000152901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000137">
        <property type="entry name" value="DnaJ homolog subfamily B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO29878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000152901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43744" checksum="8D56B3975892D98C" modified="2016-09-07" version="1">MMTCLRDKGIGNLLKKAQKVNGDNEGDYHATGTDAGYGHYDQYEADSDIRSRRTKFHADRNQSAVNGERGCPDGADEGSSSSAAEAKQRTRSRSSARPKLGVHYTKEELEIVERIRHCKDYYEILNLKKSASESDLKREYRKLALQLHPDKCRAPGATEAFKALGNAYAVLSNKDKRAQYDLYGTEGPRRRTNQYEDEFSEYDYGRGFEAEFTPEEIFNMFFGGGYPASHLNRRQRGAQYHFHQQHSAQQDQSPYAPILQLLPLFAVLFLGLIAQLMVGDPAFSLHRTGKYTEERFTRDLQVPYYVKTDFLTNYRSKVAQIEHQVEDEYVSHLRMKCYRERNERETALWRARTFGDGDLWNRAQRMATPSCDRLQEIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2A2</accession>
    <name>A0A183H2A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhoLip_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1611</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000795">
        <property type="protein sequence ID" value="VDO30154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2A2"/>
    <dbReference type="STRING" id="387005.A0A183H2A2"/>
    <dbReference type="WBParaSite" id="OFLC_0000161101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000161101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000161101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO30154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000161101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22650" checksum="819E0114D5209F65" modified="2016-09-07" version="1">MHRGLIISIMQAIFSCVFYFASVSLYQGVLMVAYSTVYTMLPVFSLVVDRDVTALNALTYPELYKELGKGRSLSYKTFCIWILISIYQGSAIMYGALLVFDSDFIHIVSISFTALIVTELIMVALTIHTWHWAMLLAQALSLSLYAGSLLILDNFFDRQFVTTWIFLSKTTAITAISCFPLYIIKALRRRFSPPSYAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2B2</accession>
    <name>A0A183H2B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1622</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000803">
        <property type="protein sequence ID" value="VDO30207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2B2"/>
    <dbReference type="STRING" id="387005.A0A183H2B2"/>
    <dbReference type="WBParaSite" id="OFLC_0000162101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000162101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000162101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF170">
        <property type="entry name" value="RE50361P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO30207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000162101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="860" mass="97031" checksum="54232ED59F361D51" modified="2016-09-07" version="1">MKFQVLEELPSANIRSLQLISCGIKKITNATFAKLADNLEHLTITENMLTTVTLPDHLPKLISLNLSYNQLTDLSDNALKGAESLRHLRLEGNKICSLSSNSFLDIKNVLELLDLSDNCLNNIPAQNLRNCIRLMYLDLSHNAIKEITNFELMNLPLLKELRINNNQISYIAPTAFMNVPLLEHLYLRNNLISSIETERLFQVFKNLEVLDLSENMLTKVPSFKALSNLRQIHLNHNKISQIETLAFSSNRKLQLISLQSNQIISMSRNSFDSLDELVVLNLANNAIKKIERVMLDGMRNLQQLNLRNNSLNVLENLTFTSVSQITTLDLGHNSIHKIEKNVFTPLKNIFWLDLSSNLIKTIEKDTFREKIANILLNDNPLHCDEKLDWLVSYLVANQVRTFLPYQNEVLCAGPEKYIGVRLKELMIVKANETVSKTRYYGNSQNDADRDMLSNILSSGDHDLHHNLTPMQSPSLLEMVPVIDALTDTLPSIQNIAGINYLAKTNEEHTHDIQKFNNAIEQLSSPLLRVTTRKQSRLTDIEQFIQATPNLTVNVPGMGDIDISKLPAGIIAHVLRGGQIPGLPPETLDKIMKEYLKRMFAAAAAEATKREKLVIAESRYLLQREKLPQILITQAADISSSPERHETQSIRENNAPDQLKNLSGEKSSGLSSTVVEVMRMLPPGYNISKIPKPVIDALFRGEVPDFTLLPSELQQHFLTDGHRLISALSTDANKTVEEILYNLPTFTRPIKPTFVPYDINEVSNDLTETKHRAEKLVRVQYYTALLLGFVGAASIAVVGLICVYMKRKRLGDKELDIDEDSLMNASQMPQPQQSTINGLKMDTPLTKHRQHLSGSSPMFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2T9</accession>
    <name>A0A183H2T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000919">
        <property type="protein sequence ID" value="VDO30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2T9"/>
    <dbReference type="STRING" id="387005.A0A183H2T9"/>
    <dbReference type="WBParaSite" id="OFLC_0000179801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000179801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000179801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000179801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7677" checksum="9396512D2DF2C1BE" modified="2016-09-07" version="1">MYILGDKSDFTDQIITLIADASIDAEQHIIGNAKEIISREPIVCLCTAADCEAMNCVIPYLNVSLNFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H331</accession>
    <name>A0A183H331_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1890</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000989">
        <property type="protein sequence ID" value="VDO31137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H331"/>
    <dbReference type="STRING" id="387005.A0A183H331"/>
    <dbReference type="WBParaSite" id="OFLC_0000189001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000189001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000189001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="215"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO31137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000189001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="820" mass="92198" checksum="EF8B23E3BF296478" modified="2016-09-07" version="1">MMGMRSSTFYIAHTIIGFIKIALVLLSCTVILLPQIQTISSWLFFSTNFIYGVGAASFALLMSCIFHTPDAATKGTIVIWLVTIVLTILQATDGSVLLNIILSLNLNYAFICAHRAMQDYMNRDEYLGIYNMFENTIYMYSFGIALIMMIFDIVWMSILAIYLDNVYPSGDLPRKHWFFFLHRSNNKHQQCAFYDSSDAPSDNIQKYEGDDQADIDIRHLTKTYTVQPAVDSMSFRAYRGEITVLLGQNGAGKSTTFSLITGLISPTSGSIYICGNKMESHSIDHCQREIGFCPQYNALFNLLTVREHLEMFRKLSGNTIDCVMGLMTDMQLDNVADVFEISAVLKLIERNCVPKLLSDIVKIAEKLSGGMKRKLCVGISLVGGRRIILLDEPTAGMDPASRQAVVELLQRYKRGRTILLTTHCMDEADLLGDRIAIMVRGRLFCAGTSEFLKNRFGTGYLLSIDLVPRQSSHHSLTQKEQLLTIIRKHIPETRKHSITPQQITVLLPTESKKSFPNLFIDLEQNAEKYDINSFGLSLNTLEQVFLKVGELEDANSTALIDIENMAEQQASILCSNSFIRTGLLLWIEQVIALLRKRFICYKKQWPRLIWQIVLPVIVLLFVVFYMKNLSTRDEKRHEILLNAGRIKPSVVLLQLENPETLFGHNILQIVRNITGYSYKLVPPSEKMELSLAKLPKIPPPVSMAVTYNTKNSYIAATAFFSAKARYGPVIATTLISNARLGQSANSIKVSFLPYGNVSDVSPLVSLNSDMFLIAPVLIIIFAFVSSGFVAYIVDDLNTNFLHQASFSYGFNQDKLKLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3N1</accession>
    <name>A0A183H3N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001136">
        <property type="protein sequence ID" value="VDO31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000209001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000209001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000209001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000209001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17168" checksum="8983BA5DB1C92971" modified="2016-09-07" version="1">MQMTSNDIFDNCKESQQSIRSISQNKTTNNLLKNDADCQNKPKLNVMEIELTRGGRMKQVEMLNNFGLERSLTATYNDNRSILELLPRTVSPKAISKISNQNEHNDCEKIERNKNLNLCKQTNFILEAFYCTTYYNINISYQRNSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3S9</accession>
    <name>A0A183H3S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Receptor-binding cancer antigen expressed on SiSo cells</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2141</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001172">
        <property type="protein sequence ID" value="VDO32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3S9"/>
    <dbReference type="STRING" id="387005.A0A183H3S9"/>
    <dbReference type="WBParaSite" id="OFLC_0000213801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000213801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000213801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017025">
        <property type="entry name" value="Cancer-assoc_antigen_RCAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208:SF2">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000213801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22379" checksum="EF63CFA2BCD024E5" modified="2016-09-07" version="1">MFTIQALKKRALFIFRLIVAILGKLCCCFKRRKNIGELPYTIAHQSPQTYWKSVSNGEKWEGWNDTPFVISVEEKIMEYRRKKTESEVVAEEKVEADFFTDMQPKVVQTRKAYVGSCDNTGVQSSNLFAVKTDEVLPPYVDELGILEDTNKCDKTEEWDTEIDIESVNSALREVKEFYSAKYGNFRYFILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Y3</accession>
    <name>A0A183H3Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001209">
        <property type="protein sequence ID" value="VDO32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Y3"/>
    <dbReference type="WBParaSite" id="OFLC_0000219201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000219201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000219201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000219201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21830" checksum="EBB17F40071C09D8" modified="2016-09-07" version="1">MFSSRPGLLDTESSGFVGDCRAGQVRCGITLGTGMIDNWCLREIDVERSVTSFSVVLFGSKKMRLRSNRNTEEPYPTVCHLNTTQSRKVDSRGMKRMAPTIRDEKSAKKKVQDLSAPTTSGCSSTAHHHHQQQQPLNSAVNSDNNAQLVKCKSNKSSRGKSDKTQEDNIQKDISSIPDHILVGFLLVVPSAILIRMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H465</accession>
    <name>A0A183H465_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2272</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001271">
        <property type="protein sequence ID" value="VDO32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H465"/>
    <dbReference type="STRING" id="387005.A0A183H465"/>
    <dbReference type="WBParaSite" id="OFLC_0000227401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000227401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000227401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000227401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19161" checksum="F605A06D91B7A303" modified="2016-09-07" version="1">MNLFSSMGYMGTGHKVLFVWLLLLLALIFLVVYLDGGMDGEPSIFFMILGFFDIFFLSSTTIRVMRHYQICGVGRRQYDLDEPYPVTAYFYPLDKRTSAVAIALLVFKVIFEILLYIRLKFGMIQTFWLTVPFWLFLFILIIELTFRLFSIHNRPGIKIRQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4C8</accession>
    <name>A0A183H4C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001320">
        <property type="protein sequence ID" value="VDO32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4C8"/>
    <dbReference type="WBParaSite" id="OFLC_0000233701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000233701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000233701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000233701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7647" checksum="EB66148FF716F8FC" modified="2016-09-07" version="1">MGAIVKVRPARCIESFGMVYSLFAVLPPKLHVDQGHRESFIAFLPFDHPWYTMDCLLRFCRSTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H594</accession>
    <name>A0A183H594_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRESAN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2653</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001567">
        <property type="protein sequence ID" value="VDO33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H594"/>
    <dbReference type="STRING" id="387005.A0A183H594"/>
    <dbReference type="WBParaSite" id="OFLC_0000265301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000265301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000265301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000265301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18434" checksum="954468EE85210B52" modified="2016-09-07" version="1">MNIEIKFYLQHLELVLSVMKLLRINQTYLDTTAGFLMEYRNKPNKSIRLLYHEASAIDKHIIRQAEYLEELEELSDPNHWIPFESFYQLIKDKAIANWEEICGKVTQCVAPEDDSKMSSQGTVSDSDHGGSLSDHNTASLAPSAASLCNIVLHLLIILFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6M2</accession>
    <name>A0A183H6M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Filamin/ABP280 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3134</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002001">
        <property type="protein sequence ID" value="VDO35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6M2"/>
    <dbReference type="STRING" id="387005.A0A183H6M2"/>
    <dbReference type="WBParaSite" id="OFLC_0000313301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000313301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000313301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000313301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13081" checksum="87564F7259B3006D" modified="2016-09-07" version="1">MNEQRHYLSQLYVVPAVDAVDAGKGQLEISINQGKVPNNVQMQGTGRCLVTFIPQYPGKYVIDVTFNGEQVQGCPIRVDILPKQVGQSVSTSVISQQTATITSPSSGPFLLKLFQKSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6Q7</accession>
    <name>A0A183H6Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3169</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002041">
        <property type="protein sequence ID" value="VDO35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6Q7"/>
    <dbReference type="STRING" id="387005.A0A183H6Q7"/>
    <dbReference type="WBParaSite" id="OFLC_0000316801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000316801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000316801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="128"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000316801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49468" checksum="25FADF50F365BC21" modified="2016-09-07" version="1">MTLLNQTSIDDWSGSQFDYLDHIITCTQNPYQIVTRLGIPCLSAFGVPIQPYVILGEFNSSNQWDSARGVVITILLNNHVTAVENKYAAAWEKVFALYLRNISHYNYAISFIAERSIQDEIDRESQSDVFTILISYIFMFAYVAFALGQYQVTGNDLATLLVHSKIMLGVVGVLIVALSVTSSIGLYAFYGIPATTIVLEVQPFLVLAVGVDNIFIFVQAYQRAEEPLSEPLHLRISRICGEVIPSMLLSSLSECLCFFVGALSSMPAVKVFSLYAALAIFFNFFLQITCFLAIFILDVRREENGRPEVCCCLRITTVENFNNDGYMLYLFSNYYAPFLLSKYVRVIVIFLFAGWLTSSFAVMGNIPLGFDQKMAVPEDSYVFSYFKSMDRFLSVGPPVYFVIKGNIEFSDPYEHNKICSGAGCAADSLGAQIAHAARWSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7A2</accession>
    <name>A0A183H7A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trichohyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002225">
        <property type="protein sequence ID" value="VDO36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7A2"/>
    <dbReference type="STRING" id="387005.A0A183H7A2"/>
    <dbReference type="WBParaSite" id="OFLC_0000336301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000336301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000336301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000336301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="30438" checksum="80AA7005811C07D4" modified="2016-09-07" version="1">MDFLRNKKLVKKMPDGRIFEASIKVDFDKNRHLSDENIHKRYVERERLKELEKQKISEEYRKREKEDENKMNAEKEHVDHRSQKEGKHRRKRNQEERLKKERLNEMIVKEERKLLIAQRKLESRRLLSALFWRIEVANLREKNSRLEMSSRDLEENLQAELETKLRQALLREQEQRLRKRVWFSIPEFTIPEKKFSHMQARRLETLPTEEENSLARSIHIVNSLKSFTLPWTPDERDLTPDYLIVLGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7P5</accession>
    <name>A0A183H7P5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3507</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002355">
        <property type="protein sequence ID" value="VDO36758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7P5"/>
    <dbReference type="WBParaSite" id="OFLC_0000350601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000350601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000350601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000350601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39974" checksum="54BE1BDB886D401E" modified="2016-09-07" version="1">MGLGTVIDISTTPMRSIKNDCAGETAGMSSDQISTTLRPSSLLLDHSVVSSPEVKDAISSEHSNLRHGIQLSEAHEDVPSDPFVFSVHQLKGNEVRATNGTSTVLAAKQQSENCCFDSSNCPHDPEPSTSKEGLVSKETDNEQKNDALSLINGKCNLKTSNNVRNSNQIAAINSEEPDKDATTQLAICVPCESRNQHIGNTNLSKQISPAIPKQELFPAVDIHQGVPRRSLINTAPLSPNHYGSILAQTVLPFRINKRSHLSGSYKTSVHSNTNEMSIRPEREITTDVKELQQKKQKIQEERITPTYLAPSSSLPVAGTGEDRLQIPSEQILNKALDLLRKPAQEDRNEPKTATKRNYSKKISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7S9</accession>
    <name>A0A183H7S9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3541</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01002393">
        <property type="protein sequence ID" value="VDO36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7S9"/>
    <dbReference type="STRING" id="387005.A0A183H7S9"/>
    <dbReference type="WBParaSite" id="OFLC_0000354001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000354001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000354001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000354001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33190" checksum="D9D9EDDE47F91186" modified="2016-09-07" version="1">VDELIKAALHTDPVRIGIDEKELKDGNELATVSGLQQGYVVCPSEKRFLLLFTFLKKNRDKKVMVFFSSCNSVKYHHELLNYIDISVQCIHGKQKQQKRTCTFFSFCQAKSGILLCTDVAARGLDIPQVDWIVQYDPPDEPREYIHRVGRTARGVTGTGNALLILRPEELGFLRYLKHSKVVLNEYEFSWSKIANIQLQLEKLIEQNYYLNKSAKEAYKCYIRAYDSHSLKNIFDVNTLNLIAVAKSFGFSAPPFVDLPISNKPKVLVRSKLSGAGYRKKPKAFKQLHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H802</accession>
    <name>A0A183H802_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3614</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01002479">
        <property type="protein sequence ID" value="VDO37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H802"/>
    <dbReference type="STRING" id="387005.A0A183H802"/>
    <dbReference type="WBParaSite" id="OFLC_0000361301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000361301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000361301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000361301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37083" checksum="182A066A448D35CD" modified="2016-09-07" version="1">MILINGAEGIGTGWATKILPRCTREVINNVQRLIDGRSLQNMLPHFRNFQGTIEETSPYQYIITGKVSYRRLRSGLKATITELPVGIWNNKYKEKVLDFVIKNGLIRNYEELHTESNVHFILHVIDKPLISDKKQIKILNRLLKLRSAASENSMILFDEKNALRKYNSMEDIFQEFFEVRRQKYMERKEYELKAMGQKLKFTENQVRFVNAIIDGEIIIEKKNRAEIIIQLAEKGFDSNPMKMKTSLNGSRISPDFAYLLDMPLCRLSNEEILILQEKRNELWRQFEALKSTTWKSLWSMDLNVLSTALDKEERKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8F2</accession>
    <name>A0A183H8F2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3763</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002622">
        <property type="protein sequence ID" value="VDO37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8F2"/>
    <dbReference type="STRING" id="387005.A0A183H8F2"/>
    <dbReference type="WBParaSite" id="OFLC_0000376301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000376301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000376301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.50:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="7">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000376301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25790" checksum="37DE284E0674D37E" modified="2016-09-07" version="1">MKPDIKDRDYMYRLIIGQLFYDGHQQLALNLASAIGCSAQPPPPSDKLFRLVSMAKQFVDEPDPKEKDNIIQMDISSGLDLEYDADIEPTSPEPSMYETIYLTAHKSPCRASAFNSDGTLLATGSADCSIKIMDVERIIAREVRGEINLIENGPDAQHPIIRTLYDHIDEVNCLSFHPREQIIVSGANDFTVKMFDFSKTAVKRAMKTIFVSFVLFYHLIFFSFILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8M1</accession>
    <name>A0A183H8M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002698">
        <property type="protein sequence ID" value="VDO37909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8M1"/>
    <dbReference type="WBParaSite" id="OFLC_0000383201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000383201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000383201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000383201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14795" checksum="6ECA606B313A2B18" modified="2016-09-07" version="1">MTPKIAGRKWNEVDVCATQSLAHSSFFASLIGCAKPSLSPKTLIMIDITDTDSYTSNYKYFFILHRGDGGGEELLHICLSRQIGDYELSCAKSLLRRGSRTTSEGASPTECLLITDTGDYHRVCLEHFRKAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8V6</accession>
    <name>A0A183H8V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002790">
        <property type="protein sequence ID" value="VDO38231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8V6"/>
    <dbReference type="WBParaSite" id="OFLC_0000391701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000391701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000391701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000391701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9952" checksum="91ED10C6F5A467BD" modified="2016-09-07" version="1">MLLTVLPKKSQGFYNSGTNNLNDDINDDNDTSTDDDISSDDETTTAFNLEEWVNSNLSDSFTNTRMFPLRRMPRINFATAHMIQQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8W7</accession>
    <name>A0A183H8W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3929</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002799">
        <property type="protein sequence ID" value="VDO38260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8W7"/>
    <dbReference type="STRING" id="387005.A0A183H8W7"/>
    <dbReference type="WBParaSite" id="OFLC_0000392801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000392801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000392801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="72"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO38260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000392801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34099" checksum="D96FB13BC1CE0350" modified="2016-09-07" version="1">MKRYKWEQDQLQHMKEYIARFGHGSAKLARQAQSKEKTMAKMVAVGLTEKVVTEKVKQFYFFDPGTIPPPVIMVQHVSFQYNEKTPLIYKDLDFGIDLDTRIALVGPNGAGKSTLLKLISGDVMPSNGLIRRHSHCKMGRYHQHLHEELPLEKSALEYLMMSFPDVKEKEEMRKIIGRYGLTGREQVCPMKQLSDGQRCRVSFAWLAWQQPHLLLLDEPTNHLDLESIDALAEAINCFRGGMILVSHDFRLVHQVAEEIWVCDKQTITKWDGDIFTYKDHLRKAIEKNCSEVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8X9</accession>
    <name>A0A183H8X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 2-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002811">
        <property type="protein sequence ID" value="VDO38303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8X9"/>
    <dbReference type="STRING" id="387005.A0A183H8X9"/>
    <dbReference type="WBParaSite" id="OFLC_0000394001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000394001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000394001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000394001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14783" checksum="BFEF1621FA9539D0" modified="2016-09-07" version="1">MGLNRGSGSDKPISSTDHISKLGEQKALTCEDTDEVEIDEETEVAPFPKTSEKLEIGEFKNSESVISDNDTAEQPPTSDEKQNLEENFTNMNIRMGERLTDDIIDAYCDKLQESVNREVDGMLAMQYILVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H963</accession>
    <name>A0A183H963_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4025</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002905">
        <property type="protein sequence ID" value="VDO38625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H963"/>
    <dbReference type="WBParaSite" id="OFLC_0000402401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000402401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000402401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000402401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11759" checksum="AF2E858A5FA3DEED" modified="2016-09-07" version="1">MGGWLDLCACDKSLCNTFSYLRSNAKREEEVPSGDSLIFSRIHRNSTAILESNICAYFSVDSNPSHPEPDAPLSTRTSFLTILLVGVPLAVGAATVVVVAFNYYCHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H994</accession>
    <name>A0A183H994_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002935">
        <property type="protein sequence ID" value="VDO38721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H994"/>
    <dbReference type="STRING" id="387005.A0A183H994"/>
    <dbReference type="WBParaSite" id="OFLC_0000405501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000405501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000405501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000405501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19701" checksum="9F0C2A24436F27E9" modified="2016-09-07" version="1">MNAALCRICDEEWRYSPHSRKCYRLFTKPMTWTEAEFHCRMQRANQLSIHNSRENRFFKEIARDVSEIWLGIAKFSVLTGYEWSDKTSYNFKGWKNGRAPVTKLTEPCTKMNVTNGEWFQSCCRKSAPYICQKNPQTVKHFASNKQNYEMIGGNPAFEQFRFLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9D9</accession>
    <name>A0A183H9D9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS4101</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002990">
        <property type="protein sequence ID" value="VDO38881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9D9"/>
    <dbReference type="STRING" id="387005.A0A183H9D9"/>
    <dbReference type="WBParaSite" id="OFLC_0000410001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000410001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000410001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="14">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO38881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000410001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37089" checksum="D702BC757E314178" modified="2016-09-07" version="1">MDEIAEEYVSSMEETFVESTTTPQSIPLCDMCRKDSWKYRCPRCSFRTCSLPCSKEHKVKYNCSGERDKSFDVLKRLVDYSPSVAVDDEKFLSTVTTSLNNATERLTQINHPDASINQSNENDKLEVSADVTAEEVIATHHEHFVSGLEENGNNLSDEINDEKEVASLQVDSGKEFTAEHMEWKVIAAKRYLLNNAHRRRIWLTLTPDKEGNSSRHEQYSDTIFWTIKMVFRREEQVEAGKRIIEDGYTVNNIPESICATTLLRQFIKPKKIGPVVSKSDLDAEKMAPFQEAGMDKLMVYMPVPIEEKQRYIIILEKKNLMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9N1</accession>
    <name>A0A183H9N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003089">
        <property type="protein sequence ID" value="VDO39226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9N1"/>
    <dbReference type="STRING" id="387005.A0A183H9N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000419201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000419201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000419201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF30">
        <property type="entry name" value="FUMBLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000419201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21169" checksum="46910441F813088B" modified="2016-09-07" version="1">MHNFSIGGGFFQGICAVMCGCETFEEAIELASRGDNKNVDKLVKDIYGSGYDQMGLAADVIAASFGKIYNKKDRDKARIEDLARSALVTTTNNIGSITFNGAKTCGIDRIVFVGNFLRVNPIAARLLSNAMDFWSQGTKKALFLIHEGYFGAVGCLDKLVDVTETRRRIRAENQQQENSSNIRNLKGLGLSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9U1</accession>
    <name>A0A183H9U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inhibitor_I29 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4253</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003151">
        <property type="protein sequence ID" value="VDO39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9U1"/>
    <dbReference type="STRING" id="387005.A0A183H9U1"/>
    <dbReference type="WBParaSite" id="OFLC_0000425201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000425201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000425201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000425201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21413" checksum="9F5757FA549BE8DF" modified="2016-09-07" version="1">MLIQLQHACCNIAMYDTSQITKLYDNFLTKYPRDFNSDTISYKERLKIFRENVQLIEKLNNENSSAIYEINKFADWSDKEFNAFSGPLFKPNRRVSRSYDPNWIRVIPDGTPYPSSWDWRKKGAYECHSCYAYAVAAVIESLYAIKYRQYISISEYEMLDCDYNNNGCKNGSIKNSMELVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAK6</accession>
    <name>A0A183HAK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PINc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003464">
        <property type="protein sequence ID" value="VDO40217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAK6"/>
    <dbReference type="STRING" id="387005.A0A183HAK6"/>
    <dbReference type="WBParaSite" id="OFLC_0000451701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000451701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000451701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000451701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9532" checksum="3B3730E7176A7C78" modified="2016-09-07" version="1">MKEMQQFGAEYGCCDQVDVEVLLLAYCRNHQGSCWAILGSDKALSLSCNQLRQSNMQMATIVRALAPEILVLRSSRVSSASESFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCK0</accession>
    <name>A0A183HCK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GINS complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5211</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004354">
        <property type="protein sequence ID" value="VDO42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCK0"/>
    <dbReference type="STRING" id="387005.A0A183HCK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000521101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000521101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000521101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000521101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16903" checksum="0057F45C8790A9D0" modified="2016-09-07" version="1">MSGRFLVEEESEYDATVSGIEELRSSSGVQLVDPVEEIETIGDDADESITPSQLVKEITIAWQNEICAPRLLPHMQVTDMSLIRETFVDLMIDQLESMEENFNKCKDHTSLKIILHKMEVQRLAYMVNEYIRTRLKKVSVSRNLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDK3</accession>
    <name>A0A183HDK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NFACT-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5564</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004847">
        <property type="protein sequence ID" value="VDO43561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDK3"/>
    <dbReference type="STRING" id="387005.A0A183HDK3"/>
    <dbReference type="WBParaSite" id="OFLC_0000556401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000556401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000556401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT protein C-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000556401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11851" checksum="E46C9ECF8922E6FB" modified="2016-09-07" version="1">MIVMDTEETKMLNSLTWRPLDGDVLLFALVVVAPYQAMQNFKYKVKLTPGIGKRGKAAKSAIALFQRNKLANAQEINLLKVLATDDQISRNIPGKVRVSAPQLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG24</accession>
    <name>A0A183HG24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS6437</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006117">
        <property type="protein sequence ID" value="VDO46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG24"/>
    <dbReference type="STRING" id="387005.A0A183HG24"/>
    <dbReference type="WBParaSite" id="OFLC_0000643501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000643501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000643501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15513">
        <property type="entry name" value="PHD5_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="265"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000643501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41604" checksum="1B905C48AFB8D702" modified="2016-09-07" version="1">FTHSDCDSDSLSSNAVETEYVCPICRNSPLVADAMMISTGNSSVAASPTSISTHDETSRSNPLDNPYCMDSPSNRNSPLMSLSQLDTFGDFFNINQSTGQVPSMSPSGSTAMSGPMSSCRASPGSFPEFSNTGDTTDELRFSSRRERSDTSNFNRTSRGGGVKKPYGRGMTSRTRSLGGMSDFTEVIHSHRGKRGGRGGNKNGRGRRPRGGKTSAMLAMVNAAAANRDIDQESSEMDDTRHRMEENDYIRTVVVTCAENSYFLQMPLCLICGSIGKDVERTMVTCATCSQSYHTYCVGLHDKLNSTIIRRGWRCLDCMVCEGCGDGHDESNLILCDECDISYHIYCLEPPLERIPHGPWRCKWYISKFLHFPENFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGM5</accession>
    <name>A0A183HGM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6637</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006431">
        <property type="protein sequence ID" value="VDO47245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGM5"/>
    <dbReference type="STRING" id="387005.A0A183HGM5"/>
    <dbReference type="WBParaSite" id="OFLC_0000663601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000663601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000663601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000663601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18456" checksum="EE38A9A4B5E65676" modified="2016-09-07" version="1">MLDLTRIPVPKDFADGIWQFVLNETVEYLAKYSNLRFFSGAIYDQDGDGVRDSDEIIRKSNPSHLFFVLMWCENNVLISHTLCKDVIFIPYILPVKGRNLNCLKSSEYLYDNTARMRDIELLTGMEFFTNRSIWSDVEAIQLRTLLPERKRHRDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHN9</accession>
    <name>A0A183HHN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007027">
        <property type="protein sequence ID" value="VDO48830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHN9"/>
    <dbReference type="STRING" id="387005.A0A183HHN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000700001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000700001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000700001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000700001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33661" checksum="A484F88DE2A415CC" modified="2016-09-07" version="1">MAHCCVRPPVTGCILFAECHDLFVRLPGCSTQHYIFDNSMMCSREDGILRQIPFAHLQDVVFLVSIIRTQLAHNAFFESLVRAHSRSACVDENIVDIHIASSYIDFFDLQFYLKKNLFIARVAVSPSNINVSLECVINGAVLPESQHATAILTKSWSLAIMMRSVLRRGGAISLAALEKPFVMNENVDNNCDVKISQSWLFVPNITDSSINYNKIEHEYVVDERINLNCSHDNNTLGRQSPLSLLALFKELGKIEELIPPQKPMNGAQQCTAPPRNEMLAPRTSRIHSENTMTINAFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIN9</accession>
    <name>A0A183HIN9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DIS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS7352</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007627">
        <property type="protein sequence ID" value="VDO50593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIN9"/>
    <dbReference type="STRING" id="387005.A0A183HIN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000735001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000735001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000735001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000010">
        <property type="entry name" value="Rrp44p homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="CSD1" evidence="13">
        <location>
            <begin position="114"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CSD2" evidence="14">
        <location>
            <begin position="259"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO50593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000735001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37701" checksum="39240A765489451B" modified="2016-09-07" version="1">MYKLCYESPDRKIYVFMDDFHYETHLDRITGESEEDRLTRSLIMCAKFYANHWKEFPIIPIVVCGTAVARDRLKQQFENVFTLQEYIEGMKDNADLLDKLAVYNAESENRGRILFPEYLAHDLIQNGIRNGKFKKGVFQVSRENYTEAYVHVDEGTTWFIQGRINMNRAVNGDTVAVELLPESEWTCPQKVIRLRDVEEIEMKDAVDKEDDKDEEEIQPKKPRMEDKIPSARVVGIVKRNWRQYCGMILQPAMKDSTRVLFAAAERLIPRIRIETRQAERLKGKRIIVAIDGWPRDSRYPVGHYVRSIGVAGDRETENEVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ19</accession>
    <name>A0A183HJ19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA_mis_repair domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7481</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007845">
        <property type="protein sequence ID" value="VDO51177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ19"/>
    <dbReference type="STRING" id="387005.A0A183HJ19"/>
    <dbReference type="WBParaSite" id="OFLC_0000748001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000748001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000748001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000748001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26479" checksum="D40DFCAD49E934A2" modified="2016-09-07" version="1">MIKSIDVNVSPDKRSVFFEREKQLFALLRASLLATFAPHLGHVDISNQSTNTNDISHLESMNDSFIHLTQPDDNNDSFDVSTQNLDSSSESKNNSPPSTNSFVRDKLRGPSIDLMNIKETTEKTRKRPASNNCSEKSTSVQKRPAANLFEKFAFKVIPHSSNEVTTDSSSNNDTSLESSSVVDQREKVDFRETSLRTVMAGASKDENNVIMPQEDADFPDLSEDDDDDVLLTAAKDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJC1</accession>
    <name>A0A183HJC1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7582</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008009">
        <property type="protein sequence ID" value="VDO51688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJC1"/>
    <dbReference type="STRING" id="387005.A0A183HJC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000758201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000758201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000758201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF21">
        <property type="entry name" value="PROTEIN 4.1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO51688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000758201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25309" checksum="19ED2D4187200F03" modified="2016-09-07" version="1">MTTIFKFLPGHPWDFNFKVKFYPPEPATLAEDRTRHLLSLQVQHDISTGKLPATLATYALLGSYVAQSVRGDYESSLQYIDFLKSCHLAPLPNETLYEKIEELHRHHKGETSAEADLHYLENAKKLSMYGVQLFHAKDGKGTPVQIGISAYGINIYLDQIRVNRFLWQNIIKIGYRRNIFIIKVKPGELEKNESAVAFKLPDYEAAKRVWKCGVEHHTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJI4</accession>
    <name>A0A183HJI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin candidate 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7645</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008123">
        <property type="protein sequence ID" value="VDO52023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJI4"/>
    <dbReference type="STRING" id="387005.A0A183HJI4"/>
    <dbReference type="WBParaSite" id="OFLC_0000764501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000764501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000764501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000764501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18713" checksum="69B8CCFCF8125704" modified="2016-09-07" version="1">MSSWLRNIQGQLSEFASEVLNEAAEEVDDPESELQVTRKKLVEAEKELSNEKENVQRLKKKIDNLEEELYAKNLELDAVNEKYTDVIVSRDTQIRELQAELERTYHVIHHESSDGDEDSFFPANSTRIARMKDEIDQLRKEAAHWKRLVNEQSEKSGALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJU3</accession>
    <name>A0A183HJU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7755</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008300">
        <property type="protein sequence ID" value="VDO52417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJU3"/>
    <dbReference type="STRING" id="387005.A0A183HJU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000775401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000775401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000775401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000775401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16621" checksum="46DA22E628DE22B2" modified="2016-09-07" version="1">MISRRVQIDGRICSDRMSSKMSVFIDSALLHIGVDGTIGTTRSSIDKSSSKMSENLVNVLHFRLTGCLANFGYIGSQNEMEFHIDGSVLSLQDSRIDSASRGYAALKQIKGISSEASDSLPTSSTLSSAILYQKPDTVAQLLEDGVDLNDSIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKV0</accession>
    <name>A0A183HKV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8113</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008920">
        <property type="protein sequence ID" value="VDO54054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKV0"/>
    <dbReference type="STRING" id="387005.A0A183HKV0"/>
    <dbReference type="WBParaSite" id="OFLC_0000811101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000811101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000811101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRHL1/CP2 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000811101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11188" checksum="0C75CBBB3F4FD5B7" modified="2016-09-07" version="1">MLYVRKRDEQIYTPLHIIPPSLTGLIQAVVEKFGVESEKISGLFKQCTKGVTVKLDDDMLKHYCNEDTFIIDIEQAQDDPSCCTVTLVELPPSHFSQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKV5</accession>
    <name>A0A183HKV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA_ligase_A_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8116</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008932">
        <property type="protein sequence ID" value="VDO54076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKV5"/>
    <dbReference type="STRING" id="387005.A0A183HKV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000811601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000811601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000811601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070421">
        <property type="term" value="C:DNA ligase III-XRCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase ATP-dependent N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000811601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15815" checksum="F1C18EA58D9A9F51" modified="2016-09-07" version="1">MMISEGYDGDLYLLLKFLIPEADQRVYNLKAKQIIKIFSTQFDWSVDELTESYNHTGDVSETICSFSSKLDDGPKKSKITNQMVDDWLEKLSELTREKEQQSHFSKICKLVSCLELKYIIRLIMKDLRINAGAKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKX4</accession>
    <name>A0A183HKX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8135</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008972">
        <property type="protein sequence ID" value="VDO54178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKX4"/>
    <dbReference type="STRING" id="387005.A0A183HKX4"/>
    <dbReference type="WBParaSite" id="OFLC_0000813501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000813501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000813501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO54178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000813501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="39985" checksum="1CAB22C0893CBD85" modified="2016-09-07" version="1">MMMMMMENELKAAPGTAAAVTTAATNASAAAALQDAFSLYSAMPPGFSMPPTSTSSIPTVEECCVSNSPGSPCLKDKKGDDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGQEWKLLNESEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKNLPKKNGLTMSASSFLDPIKTQNIYQPMTTGWQQPINSVSSSPYFDSYSLYGRTGYENMIGMPYSLSSATSPASHYSQSPSCSLAAAAAQYQQVAAAQQQQHYSNAANISAVKLETSSDGATNTGTSNGESPDSGVAAAVTTESPLTSQFRAFYEPHKESSSTSASAAAAAAATMNMYMPQDPRLQYAALNGTMDEHMTLPLQHMQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLD5</accession>
    <name>A0A183HLD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8299</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009261">
        <property type="protein sequence ID" value="VDO55015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000829601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000829601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000829601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000829601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5604" checksum="B266F782A1905108" modified="2016-09-07" version="1">MNYEIQENKWRREDGAGAGVSAGVGAGAGTDAVWVRNEMEEVDYEGLEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMS2</accession>
    <name>A0A183HMS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8784</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010222">
        <property type="protein sequence ID" value="VDO57385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMS2"/>
    <dbReference type="WBParaSite" id="OFLC_0000878301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000878301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000878301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000878301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7210" checksum="111AF91F855B7486" modified="2016-09-07" version="1">MCVISSTHLKFKVTKDIKRIVLVMKWIPPYAIRQLETLADDKQSCRKYPIWQYLCCDDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP58</accession>
    <name>A0A183HP58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ELYS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011202">
        <property type="protein sequence ID" value="VDO59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP58"/>
    <dbReference type="STRING" id="387005.A0A183HP58"/>
    <dbReference type="WBParaSite" id="OFLC_0000926901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000926901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000926901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000926901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25606" checksum="AA0A4982714E2BB8" modified="2016-09-07" version="1">LQTSPPNPLVAEYLAKQQTALREARKDAEAVRRASSGDDTSPIREKSLAVMRRSRRSGRSAAVIVEKPMESVVTSETEQDSMEADSFQENVEVQSKIHDVEEAENDNSAPVEVLEKEAVVNVDSVSAVMEMKTLEETERTETEYDETRLISDQQSVDLEDRCPESTRDVSEEHEMQKKHEDKVEEEDAVSDIASSVSRASSRSRSEAADESNASWEQMPVDLEDQEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPB8</accession>
    <name>A0A183HPB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein 462</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9326</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011322">
        <property type="protein sequence ID" value="VDO59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPB8"/>
    <dbReference type="STRING" id="387005.A0A183HPB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000932901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31754" checksum="7FD4443F47BB32E9" modified="2016-09-07" version="1">IESIPHAPVTTDTISPDRIPILIPQDSSNCYREMNLGNHKGDSSKNGVARKVGSEELKILERMNKYQTVMVDLNLLTCLHSDCKKKQPFSSLFTFAYHLTVKHNRRAMSNKRIPCYLCDFESQTYTALIEHLKSVHEQYYQEHVIARSTSKELKRGRKGKQKKTVLMRGRSLSPLSDDFLETEESPDGSEEIGYDSALVLESMANMEAKNIDLAVKDRMDCIIALVCSDDEKSPVLEDSRCELNTQVLHNKTSSRPQIRSKECLGLCFNSCRPVHHYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPD9</accession>
    <name>A0A183HPD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9351</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011374">
        <property type="protein sequence ID" value="VDO59938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPD9"/>
    <dbReference type="STRING" id="387005.A0A183HPD9"/>
    <dbReference type="WBParaSite" id="OFLC_0000935001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000935001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000935001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000935001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23835" checksum="CA970AA9C17D4208" modified="2016-09-07" version="1">MTLKDIVIIKDTPNKKKESKKKKNKKQDNSAKKQNEQLSESEIRKVEDKTVDEFVDPFPSLSSHTNHENEAEESSITKPAFSLSELLSSTFSVLNSKTIKEDKNEPAETNVTNSVNEATIDISSSKAFPELGEGSKGKVSRKQAEITEKHFPYELGSPPGLCLNLAPPPGFGPPPGFGKKASSEMQVSSSSTKFSDDSVEVNVSKEVKYGNKKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPQ0</accession>
    <name>A0A183HPQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nodal modulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9457</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011606">
        <property type="protein sequence ID" value="VDO60764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPQ0"/>
    <dbReference type="STRING" id="387005.A0A183HPQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000946101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000946101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000946101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="1">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000946101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21287" checksum="85A87321034CF615" modified="2016-09-07" version="1">MLKKPQISDSLDIPAGQFSFCIPLAGIYTVVFEACHKFDKQSYEITIPQEVPLIASVSKFLLSASIELDHMVNELDDFVLSVKSSTDEQTIPAISSTPKRLTFTFYLSVLDADALVTLTPQSKTYLFNPTSHTFLFNGECRLNEITFKADKGIFLEGQVMPAIEGVNIRSSHKNNPNIIFESVTDVNGKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPR4</accession>
    <name>A0A183HPR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS9475</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011640">
        <property type="protein sequence ID" value="VDO60892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPR4"/>
    <dbReference type="STRING" id="387005.A0A183HPR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000947501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000947501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000947501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="12">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO60892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000947501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19365" checksum="25E267527E42E01F" modified="2016-09-07" version="1">MQIIIHYQSCNNENCTHIECDIRRLNEDEFVLVEIYARLVVNTLIDNNIYEADISSIGLAKISALPSVPRYNPPAQLVAVTTDVNPTDPEQAQHGVPWWLYLIAILIGLIILALLILCLWRCGFFKRNRPPTEQATYNTNTKNADMYADSQVRFAHPHMYSEERHGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPS8</accession>
    <name>A0A183HPS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9488</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011676">
        <property type="protein sequence ID" value="VDO60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPS8"/>
    <dbReference type="STRING" id="387005.A0A183HPS8"/>
    <dbReference type="WBParaSite" id="OFLC_0000948901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000948901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000948901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF8">
        <property type="entry name" value="CHE-14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO60993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000948901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26894" checksum="21BE74ED92E0D424" modified="2016-09-07" version="1">YLIWCRNFTCEPGKLCCNFADPNFQQNFTDYCIRLSTTYLYTNYNDTPIYDNNTFELVGYTAMIPTELKYSHRFRNLSHSFDLMRRSFSDMNRGGWYTTEWSLISVWFDLLNSIITDCRQSLLLSFSVVAIFAFLHLRLKSFVALITICCIVVVTVGCVTTLGWVIGVLEAIILVLVVGLSFDFTLHYGASVPNVGCNKHRVWLAARKSAIPVSLSALSSFAAGGSMLIAETHAFHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ88</accession>
    <name>A0A183HQ88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012071">
        <property type="protein sequence ID" value="VDO62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ88"/>
    <dbReference type="STRING" id="387005.A0A183HQ88"/>
    <dbReference type="WBParaSite" id="OFLC_0000964901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000964901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000964901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000964901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9302" checksum="C4D4558F3433501B" modified="2016-09-07" version="1">MEKENLFVNYVNEICQSNYEFKSIASAVSDVGIPQWVVDIRHGATHSHLPSLENLRQAAMYCRSWLWVSLCNICGHTRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQJ2</accession>
    <name>A0A183HQJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DZF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9751</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012302">
        <property type="protein sequence ID" value="VDO62983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQJ2"/>
    <dbReference type="STRING" id="387005.A0A183HQJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000975301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000975301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000975301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552611" evidence="1">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO62983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000975301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29381" checksum="78D25D6F4E7EBA29" modified="2016-09-07" version="1">MRLAVVFQLVSIPLVRCLPNLEINIANTSDVRAMLNSFLEAMHYPWKPWFGMSHNPDYWPPSVPFYDPNNDLLSLSTLEQREEIEKHSIVDLERDILKYAFKHYISFMEYHFGLSGPNYVEDSRNMEEDMNTDARMVQRCSVGVNVNLLQTETSAVMASKMQSMETVKTQSDETQELASSVGLTSGISHSLPDNEIGEQYVNSATSGNDITAVSTFASVPLSSERILEDQLSLFRNSGELKYYSVVYKYSARNCYMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQN8</accession>
    <name>A0A183HQN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012409">
        <property type="protein sequence ID" value="VDO63388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQN8"/>
    <dbReference type="STRING" id="387005.A0A183HQN8"/>
    <dbReference type="WBParaSite" id="OFLC_0000979901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000979901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000979901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000979901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12120" checksum="61BFDD574A3D0BA8" modified="2016-09-07" version="1">MLVDTFLCCCTPCKLRYRRLVDAIYPSSLTEGLINSNMQKLTFYAISRPEKLDKIGEYIVSRLSRDLYHQKYNQVKKFVSKLLDSDIRGGNGSTAAKLSRFIEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS17</accession>
    <name>A0A183HS17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10282</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013531">
        <property type="protein sequence ID" value="VDO67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS17"/>
    <dbReference type="WBParaSite" id="OFLC_0001027801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001027801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001027801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001027801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8415" checksum="D695C0A9A432A10F" modified="2016-09-07" version="1">MMNQFMRNHHHCLQIYPDHIHQYNHDVMKDENRKGDNHLIHLPHDMHYVMSDPRNKIRQLNYVPTGSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSH6</accession>
    <name>A0A183HSH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013906">
        <property type="protein sequence ID" value="VDO68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSH6"/>
    <dbReference type="WBParaSite" id="OFLC_0001043701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8355" checksum="B766669E50F015C7" modified="2016-09-07" version="1">MKKEQDHRLMLKFIGEIHYLQRKNSLLISHSSLQLFTIRRLFHSQDNLAFDPAHNFLCYIIHVVDFWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSH8</accession>
    <name>A0A183HSH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10441</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013915">
        <property type="protein sequence ID" value="VDO68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSH8"/>
    <dbReference type="STRING" id="387005.A0A183HSH8"/>
    <dbReference type="WBParaSite" id="OFLC_0001043901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001043901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001043901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001043901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14979" checksum="F7080D755B5E6458" modified="2016-09-07" version="1">MEARKRVLEQIRLDREARKLGEQSRQSQPVVATVNSPLPTVNATPPVKDTGYCQIQVRLLNGSMIKETFKSDEPLSHVRLWVEMHGKDTMDGIPFTLMTPFPRKVFTDEDMAVPIKVLGLVPSANMVVIRATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT14</accession>
    <name>A0A183HT14_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS10631</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014379">
        <property type="protein sequence ID" value="VDO70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT14"/>
    <dbReference type="STRING" id="387005.A0A183HT14"/>
    <dbReference type="WBParaSite" id="OFLC_0001062601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001062601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001062601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001062601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18603" checksum="843E434F6A55A95E" modified="2016-09-07" version="1">KKKKVILGETYIAASQRADGTWRKARRVKDGYIPQEEQPRYESRGQQMSNQNTYPIGWSPTEVVKLKKVPFFILLAGKTREQELKKPIAAALKPNAPITPRECIEKKINNLNKKLRDIEVLEQRIKNGELENPEKTQLEKIARKEIIAKEIDQLTAEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT83</accession>
    <name>A0A183HT83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAUS augmin-like complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10693</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014530">
        <property type="protein sequence ID" value="VDO70539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT83"/>
    <dbReference type="STRING" id="387005.A0A183HT83"/>
    <dbReference type="WBParaSite" id="OFLC_0001069501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001069501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001069501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001069501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14023" checksum="AD255BD983FD95E1" modified="2016-09-07" version="1">MDRFLMGDPIDRLLIEMATHLMDLFENILKDSVKFVVLNLQSFTDSEQHPLVRLKNQLAELDCSKDILLSLQRALDPSTHEFVKVVQEDLEAYEWPENVTTVQQVDSQQITNHRVKDLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTA9</accession>
    <name>A0A183HTA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014616">
        <property type="protein sequence ID" value="VDO70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTA9"/>
    <dbReference type="STRING" id="387005.A0A183HTA9"/>
    <dbReference type="WBParaSite" id="OFLC_0001072101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001072101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001072101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001072101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11984" checksum="166AF2CE52AA68D4" modified="2016-09-07" version="1">MENDEEGTSEGNTSQQSFAMKEQELQINHTQTAATCFNYMQSSSTNQHTSIPSLAPPPPIAFSNLPVPNDDEALASMLMSWYMTGYHTGYYQKSNPFPNTESSIYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTW7</accession>
    <name>A0A183HTW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015157">
        <property type="protein sequence ID" value="VDO72455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTW7"/>
    <dbReference type="STRING" id="387005.A0A183HTW7"/>
    <dbReference type="WBParaSite" id="OFLC_0001092901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001092901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001092901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001092901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5845" checksum="D0F3870EC13CBF00" modified="2016-09-07" version="1">MMTVKLYHQETNTVEGALDIHLDKNGRIYRLNNRPVSCYKIFNCSFPSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV25</accession>
    <name>A0A183HV25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11336</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016273">
        <property type="protein sequence ID" value="VDO75735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV25"/>
    <dbReference type="WBParaSite" id="OFLC_0001133701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001133701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001133701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001133701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9026" checksum="63759B842DCE73EA" modified="2016-09-07" version="1">MRRNHSFIPQQRIILSCESILMAPFLLPKEQQFIPPFLKKSLKNGKRKKKDISSYHTNTLINYSASSTKISFIKFCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVJ1</accession>
    <name>A0A183HVJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11507</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016679">
        <property type="protein sequence ID" value="VDO76959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVJ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001150301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001150301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001150301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO76959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001150301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="3925" checksum="68099720861C981F" modified="2016-09-07" version="1">MKINCKFSNFFLLIRIAILTFTLFAIPQGQNHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVR8</accession>
    <name>A0A183HVR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mlh1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11577</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016873">
        <property type="protein sequence ID" value="VDO77496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVR8"/>
    <dbReference type="STRING" id="387005.A0A183HVR8"/>
    <dbReference type="WBParaSite" id="OFLC_0001158001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001158001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001158001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein Mlh1 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001158001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17203" checksum="0171FFB8BE9E5B80" modified="2016-09-07" version="1">MKKALCATASVSLRSLFKEHIYIGAVDVDQVLIQHSTSIYLVDAQDCLRNFFYQILVLSFGNFGSYKLSECASLIELLCIADNNLSPTEAHQKAAIIIENREMLDDYFCLSITENGNLNSIPSLIDGFIPQLESLPQLILTLANDIIWHDVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWE6</accession>
    <name>A0A183HWE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11807</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017552">
        <property type="protein sequence ID" value="VDO79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWE6"/>
    <dbReference type="STRING" id="387005.A0A183HWE6"/>
    <dbReference type="WBParaSite" id="OFLC_0001180801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001180801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001180801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001180801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10339" checksum="C6239265EF8D0D66" modified="2016-09-07" version="1">MGQFIETLNGKEGSGSNLVVVPPSSSLTEALVSSPVCRGEDGAAAPVVAAGGVGFEFGIDPEDDPDLALALRVSLEEQRQRQRGGGTDVAELQPTNTDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWI3</accession>
    <name>A0A183HWI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11845</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017641">
        <property type="protein sequence ID" value="VDO79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWI3"/>
    <dbReference type="STRING" id="387005.A0A183HWI3"/>
    <dbReference type="WBParaSite" id="OFLC_0001184501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001184501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001184501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001184501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19256" checksum="32EA0ADA3293D4CF" modified="2016-09-07" version="1">MLKSAAEKGYLDAGKERKVKGPSLKHLESKRFSQIETSRYDIEEKYTKKLERMGTTGTGPVRPFPEKVDYKPDIRITYVDERGKEMESKDAFRVLSWKFHGKGPGKKQIEKRQAKQEKKELMKKMNSMDTPLGTLNKQLKKQEAMQTPYIILSGSGRDTGFVCFLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWW4</accession>
    <name>A0A183HWW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11982</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017982">
        <property type="protein sequence ID" value="VDO80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWW4"/>
    <dbReference type="STRING" id="387005.A0A183HWW4"/>
    <dbReference type="WBParaSite" id="OFLC_0001197601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001197601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001197601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001197601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20857" checksum="1C387B4D99061E99" modified="2016-09-07" version="1">MNDKKAKDGQKHKEETDLIRADICSTIRNGLLEMMINSTKQQVSTNTSSTDSKIRIKAEFRGEKFCFEMRRPVLFDELQAHLNSRCKLKLNIYYTLRNHELIIPIRNQLELDRAIELVDLDRTLRQRSLRLLLSRYQPDNRLSTFKPIPDASGTFSVQSSRIIEVIFLIILKKNFLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWZ1</accession>
    <name>A0A183HWZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12005</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018062">
        <property type="protein sequence ID" value="VDO81095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWZ1"/>
    <dbReference type="STRING" id="387005.A0A183HWZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0001200301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001200301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001200301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF10">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO81095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001200301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13330" checksum="C5AA6CFB18E645DA" modified="2016-09-07" version="1">MVSVNGLDKSGSTPLYWSSHGGHVEVVKLLCSIPNMCISAQNKIGDTALHAAAWKGHLECVKILLEHGASTTIHNNERKLPVDLASDPETRALIQLAMREAVDTNDFRNDYISESESESDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXG0</accession>
    <name>A0A183HXG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12171</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018550">
        <property type="protein sequence ID" value="VDO82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXG0"/>
    <dbReference type="STRING" id="387005.A0A183HXG0"/>
    <dbReference type="WBParaSite" id="OFLC_0001217201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001217201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001217201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001217201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14433" checksum="7249FE1518AE6DA8" modified="2016-09-07" version="1">MKYLSSMNFVHRDLAARNCLVADQRVIKIADFGLVRSCYEKDYYKVMHRTWLPVRWMSQEAIQYGRFSEATDVWSFGVTLWEIYSYGRQPYESYSHQDVIELISVRSLLECPQNCPTNIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXR5</accession>
    <name>A0A183HXR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12281</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018878">
        <property type="protein sequence ID" value="VDO83513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXR5"/>
    <dbReference type="STRING" id="387005.A0A183HXR5"/>
    <dbReference type="WBParaSite" id="OFLC_0001227801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001227801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001227801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001227801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15117" checksum="03BD97C20836ED6B" modified="2016-09-07" version="1">MFFYSAQSRALRRLSIAPQGSETRPTRQIPEAIPKQSITSIIIEDKQEEKEQERKEQKKDQRNHDQRRILAIRSSSLANTPCFPDIQVARKSNRYYYRRPTLTIDDDGRIIFDALGLIFTFKCTIIIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXW5</accession>
    <name>A0A183HXW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12319</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019006">
        <property type="protein sequence ID" value="VDO83884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXW5"/>
    <dbReference type="STRING" id="387005.A0A183HXW5"/>
    <dbReference type="WBParaSite" id="OFLC_0001232801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001232801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001232801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001232801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11008" checksum="BFC0962529CC6EF7" modified="2016-09-07" version="1">MSWALQQIALYTVCIPIIFALCILAAFCNFLVLLTRLQIKNRSGALELTFSLAVSDIWTSIVVVASLFRNSYMPVVLGINYTSVCFSLTLEVNKICYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYT3</accession>
    <name>A0A183HYT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12645</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039892">
        <property type="protein sequence ID" value="VDP11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYT3"/>
    <dbReference type="WBParaSite" id="OFLC_0001264601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001264601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001264601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF37">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001264601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44455" checksum="44BD9779F4639C74" modified="2016-09-07" version="1">MLEKNDQKLAKGNKKFNRAILLQYMDEQDFLANDPIIRNVAAVTLLIYFIAVIVGIPANIYVLIRMKKLAKNDRERYRNGTGIALCSMAAADLCSLLLILSQNLIQLYPQLNGNEIFMHYVCKVVLFLTHTVTGISVWSWLLLSTLRYLAIRHPLFHLRLWQMPCRALSFIVIVSMALNAWLLLAVQSTQFGCIQHAIFRSIAWNRLFHIVECTWSFCVPFLLIFIMDISVLIKSTTGSCNVGLMQMFSAQKKSEQIFEPLTVDCVCSKNSQILTRHKHNRTLWRWLAIALICIILNTPENMYRLIILFGMPNVQEQALHFSARMLAQALYFSQFAFNAVYLALFVFDKSTRPKSYIEHSIGRNLVPACQSSKCRKVYSEKVNGLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ82</accession>
    <name>A0A183HZ82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12794</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039935">
        <property type="protein sequence ID" value="VDP12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ82"/>
    <dbReference type="WBParaSite" id="OFLC_0001279501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001279501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001279501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001279501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="69616" checksum="21A38E85C9472415" modified="2016-09-07" version="1">MMNSQFFICCSACKLLREENNLGKKLLLLVLKILFLTKGICVQVNKHLGFCEKYRNFAPENWFSCPGLYSNQIFGEYDMICNPFRYGSKTDQISSKNEFIPDGHCVIRYKNLDYEVHCCCYWRFRHKCTIPLDSTMHVCANVTQDAINGKEQIFDTTLQTLPMGSSCFASFRLNVADDETVQLIGTSYGVPTKTDKNTYRCHQYISTSRSTRCSATESCLKMCPLLTPFSFNTSQTLTVVCCCDNRKDSMCNIKTDFGQNVLLDKNNYELTKCAHRHILQHIFSSDIYSDNCIVFYDFSLMMPLNLIYGYNMEFERSAEEIYSSKEELIVADIFEYNLENTWTKCCTEVNATKSQIDRITKSVKAWTVAVLKCNGKKEPRCDADLVEKINQKKSYYFNYYENKYGRLCYLKDFIEKENTRGRSLETTWCYEETHGRGLGEISTICCCSSIVDKPCNYIGEKYHVEKTKVYYSKKILQTRGHCMLPDGRRDLCLLTSEEKVICYYLADMKNRKVEGGCAVSLMRKPERHKLANICLLKELYNLAEPVEYLYAAEAIKIFCCSGRDDCKGSVLEMKRFKKFFETEHSKMIKTLKEEDFAFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZA2</accession>
    <name>A0A183HZA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039943">
        <property type="protein sequence ID" value="VDP12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZA2"/>
    <dbReference type="WBParaSite" id="OFLC_0001281501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001281501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001281501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001281501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9256" checksum="9580A217A0B83541" modified="2016-09-07" version="1">MIGESVKWRNDNSLRILISNLDIWVSKWGIYCWGNQNNSSTLCITQVERNKGCRFRWRDDDDDGDDAGGEGEQIDGYRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZD9</accession>
    <name>A0A183HZD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12851</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039954">
        <property type="protein sequence ID" value="VDP12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZD9"/>
    <dbReference type="STRING" id="387005.A0A183HZD9"/>
    <dbReference type="WBParaSite" id="OFLC_0001285201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001285201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001285201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001285201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7704" checksum="072F572EFB809819" modified="2016-09-07" version="1">MDGTVETMERVLRQLEVLGESLQHSSIETLIENKLPRWILEKAYHQKKTKPLQQQIVASSVLTDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1W1</accession>
    <name>A0A183I1W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13723</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040358">
        <property type="protein sequence ID" value="VDP14496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1W1"/>
    <dbReference type="STRING" id="387005.A0A183I1W1"/>
    <dbReference type="WBParaSite" id="OFLC_0001372401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001372401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001372401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001372401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14038" checksum="83C92C996C54015D" modified="2016-09-07" version="1">MEPVHDGTVHVFQGRFFSKWKRFKGAIFEENMTGRARLEIYTSDSQLAALTPSKSILLGECVAIRIVHFRNTINNDNRIIQIQPRNAPVLLIAVENVEEWHYVLCKVAFPDQVISWLLGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2M5</accession>
    <name>A0A183I2M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13987</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040517">
        <property type="protein sequence ID" value="VDP15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2M5"/>
    <dbReference type="STRING" id="387005.A0A183I2M5"/>
    <dbReference type="WBParaSite" id="OFLC_0001398801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001398801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001398801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001398801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="581" mass="64960" checksum="FDEDA33336F82E70" modified="2016-09-07" version="1">MSAVMTLKEKEMHTDDESEIEYTVAKRVASVTIESDSQVEAEVEQRSGRKRRKKRVMKRKNVNEKMDVDINVSQFNTINKGSVVQGVVLKLRMDWDGLCSTSELSSSETCTSDGREADDEQSDWVGPVNEDQNFPLPQTSTKQQRFIKTRTASAALQRKLERFIRDDSQHELIVKHWTSYRQVSRIMEFFGLEVSKRGRGTVLVKTYDKSYFEIIAWIPHMPGGVNLTGRRRLTFKVEFGVPLKGAFTGHDFEVLVNEAIRLILGQTAPNYSLGPFNEIERKGSVVVQASDVNLIWAALSVYGRFFGKPIALHFNSNGKMDIYFCISCLTFAVVFIYGLLLILVYISLPQKKPQSFEGKHAFITGGSKGIGKAIAVALIRRGCSVSLAARNVKQLELVCNELNAFAKTKKNGAVAKYYSVDVTSSYSVLEAMVKEAESELGDINILVNNAGCALQGSFDSLDVSVYEEQMSLNFLSAVYMTKAVVSKMKESRDGQIIFVNSAAGQCPIWGYTAYGATKFAMRGFAEALYMELLPYNVQVSIIYPPNTNTEGYQVSKFSNYCNASMIGISFKSLEFVFLYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I390</accession>
    <name>A0A183I390_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THUMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14202</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040669">
        <property type="protein sequence ID" value="VDP15931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I390"/>
    <dbReference type="STRING" id="387005.A0A183I390"/>
    <dbReference type="WBParaSite" id="OFLC_0001421001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001421001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001421001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001421001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30533" checksum="57A94CD67E303B88" modified="2016-09-07" version="1">MERNKKRHNHFRYNQSVKQKWVESGCCGLFFTCNGNERQAVREAYNIIESALEVWKKDDPSKEDSDNNVFGRGINSGSDEEDIADSVKRFCDQARSDKRNMKKRKIWQRPTGVNNCLFFVVKGINDKNVYDFVDYLVEMVLRERCCRLLQRVWPVEKTCRVDMVELDTEVSRLISRHFHPAEDGRWPTYLFEFKARNNDSLGKGDVMDMVLLALKQLAPDSHVSLDHPHIAILVQVVHKSVLLSCIKHFIARRKLSLHHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3B6</accession>
    <name>A0A183I3B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FCP1 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS14228</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040688">
        <property type="protein sequence ID" value="VDP16072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3B6"/>
    <dbReference type="STRING" id="387005.A0A183I3B6"/>
    <dbReference type="WBParaSite" id="OFLC_0001423601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001423601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001423601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="5">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP16072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001423601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23938" checksum="AA85DC47F11773B3" modified="2016-09-07" version="1">MRYRCPALPLRTRSTPEFSLVLDLDETLVHCSLTELPDASLSFPVHFQENTYQVYVRVRPHLQEFLERLSRSFEIILFTASKRVYADKLLNLLDPGKRLIRHRLFREHCVFVYGNYIKDLTILGRDLSKTIIIDNSLQSFAYQIDNGIPIESWFFQQDDQELLKLIPFLEQITNQKNDVRHILRARYRIRDLLPPLPYCDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3L7</accession>
    <name>A0A183I3L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14329</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040772">
        <property type="protein sequence ID" value="VDP16537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3L7"/>
    <dbReference type="WBParaSite" id="OFLC_0001433701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001433701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001433701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001433701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23017" checksum="77BF935B38033EBC" modified="2016-09-07" version="1">MKLEVTVDEVFKWSPVIWLIGIFLCCLLMNFLCYCRRIYKRRQLMRIRRQEELLLPINLATSFPYLSILSILPHDLECCSGSSSMYRSSVTSLPSYNEVVANPHYMARLLVSIISSLRPTHVYCFKAINNKLPDMLNLEKARKYLYFHTYKILKSFCNYLQINEVKVERTVCTTATANSYGDTSPPNYDEAIKMFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3R7</accession>
    <name>A0A183I3R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Splicing factor U2AF 26 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS14379</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040806">
        <property type="protein sequence ID" value="VDP16786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3R7"/>
    <dbReference type="STRING" id="387005.A0A183I3R7"/>
    <dbReference type="WBParaSite" id="OFLC_0001438701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001438701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001438701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP16786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001438701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26496" checksum="A2C32E9C8212CBEF" modified="2016-09-07" version="1">MAGRRTGSFGYQQTEGLSGAEYLASIYGTEKDKVNCSFYFKIGACRHGDKCSRTHHRPTFSPTVLLQNFYHNPIVDVRQADAFDKVGKKNDEEQAYFDEFYEEVFTELERKYGEIDEMNVCENIGEHMIGNVYVKFIREEDAEKAVKDLENRWFNGQPIYAELSPVTDFRESRCRQHEVTTCYKGGFCNFMHLKAISPELGEKLFGRRGRYADEAGHYPSAKRDRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I420</accession>
    <name>A0A183I420_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">External scaffolding protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14482</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040893">
        <property type="protein sequence ID" value="VDP17255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I420"/>
    <dbReference type="STRING" id="387005.A0A183I420"/>
    <dbReference type="WBParaSite" id="OFLC_0001449001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001449001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001449001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1850.10">
        <property type="entry name" value="Scaffold protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004196">
        <property type="entry name" value="Scaffold_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036632">
        <property type="entry name" value="Scaffold_D_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02925">
        <property type="entry name" value="gpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48045">
        <property type="entry name" value="Scaffolding protein gpD of bacteriophage procapsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001449001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16307" checksum="ED75F0BB9A9D7297" modified="2016-09-07" version="1">MSQVTEQSVRFQTALASIKLIQASAVLDLTEDDFDFLTSNKVWIATDRSRARRCVEACVYGTLDFVGYPRFPAPVEFIAAVIAYYVHPVNIQTACLIMEGAEFTENIINGVERPVKAAELFAFTLRVRAGNTDVLTDAEENGLRPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I596</accession>
    <name>A0A183I596_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14908</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041345">
        <property type="protein sequence ID" value="VDP19540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I596"/>
    <dbReference type="WBParaSite" id="OFLC_0001491901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001491901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001491901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001491901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18578" checksum="871307569B617AFE" modified="2016-09-07" version="1">MAEFDKDEEPLRATYTPSRPPWISCWNKRWERDRDQNKSRKVWWTELGWTDAATESGKMALARPQLREQDPEYYDPKVPDGTSLAGPMGLDSTRHPNLTWKGDQPGNYEDFMNKLYKSSTQYKDIAAKYELTEGPWPHYQGLKVMRANNNYHEFLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5A7</accession>
    <name>A0A183I5A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14919</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041356">
        <property type="protein sequence ID" value="VDP19587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5A7"/>
    <dbReference type="STRING" id="387005.A0A183I5A7"/>
    <dbReference type="WBParaSite" id="OFLC_0001493001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001493001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001493001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043543">
        <property type="entry name" value="PAPPA/PAPPA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130:SF3">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_33, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130">
        <property type="entry name" value="LAMGL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001493001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46438" checksum="AC43EE3A0CCFC431" modified="2016-09-07" version="1">MWNPLRNPVRLIQDVCLFRLRYHTFSEEPSNHAIYLNGSTGLRLSSPIWQTLANNMRFAFTLEIWIQIEGGQPDSAVIIALSDICGKEKDATTWRILIETEFNGEHGARLAVLLTPELAPELYHLRNEKAHRLGEWIQIAVVFDSHQLLFYVNGARVGKLVREFGVLYSEIRSACKRLYLGTDGNRSSRDEVVGFRGYIGKLRITDRFMDHSELIREQWQGNVFEENFADIHQWKCLGSDLGVRKEEISRKDVPRNIEIPHCGRTICDNPVVASNYLHHWNLHANKKLKYRVVVVSDDDGSNANIRTDFIMRQHVELLKAFESYNITWDLEMINIQNTSLRHKTIVFGCQSSAIGNKRCDIECRHAITGDDGGDCKIQVYQILSFQSISMNDLFTVIYLFFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5F1</accession>
    <name>A0A183I5F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14963</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041417">
        <property type="protein sequence ID" value="VDP19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5F1"/>
    <dbReference type="STRING" id="387005.A0A183I5F1"/>
    <dbReference type="WBParaSite" id="OFLC_0001497401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001497401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001497401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001497401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22517" checksum="BA33E400A8C14EF8" modified="2016-09-07" version="1">MDKRCYRCGAVDHKTPQCPSDPANANLKRVASASCISGPEQKRFIGDGVIAVESPSYAPGHDANAPGAFAYTAGSGTPGTRIDPDPELPRPLDCDLFPLYEQYMESRTKYFYFRDRLTKEVKARAHALPSISVAPLQAPYAANNIYSTPPPNALQYTVQQNSSLGSTSATTVTYPSTTGASHFYANAVNTSATGAAYPTVQSLSQPARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5T3</accession>
    <name>A0A183I5T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15095</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041603">
        <property type="protein sequence ID" value="VDP20364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5T3"/>
    <dbReference type="WBParaSite" id="OFLC_0001510601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001510601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001510601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001510601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12730" checksum="250F371309632813" modified="2016-09-07" version="1">MSESLTKGTEISKSKIRKLHNEVNEIDLSPLDKFWIIKEKVKHLDFHAGMLETIIQKLMDLIQRTTIASAEKKKKKKYAEIINDPESILNILTSAKEAMIMKQYFNALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I645</accession>
    <name>A0A183I645_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15207</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041763">
        <property type="protein sequence ID" value="VDP20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I645"/>
    <dbReference type="STRING" id="387005.A0A183I645"/>
    <dbReference type="WBParaSite" id="OFLC_0001521801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001521801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001521801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000066">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="31"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="178"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001521801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35173" checksum="DB3232840A4C23CD" modified="2016-09-07" version="1">MPNTENSYGKERTLVSLLSVLQEIDAAADETREEKTYRNWMNSMGVDPHVNWLYSDLCSGVIIFQLYDIIRPGIVNWKRVVKKFSKLKGMMDQIQNCNYAIELGKQLRFSLVGIQGKDIYDGNQTLTLALVWQLMRAYTLTVLAQCTQSGDSLATDKEIIAWVNEKVRFMNNLHHDLTCYDVSFLKCVNGIDDRLPHLQLASSGRKRFIKSFQDQTISDACVVLDLIESIKPGTISYSLVKTGTAENNLENAKYAITSGRKIGAKIYALPEDIVEVKPRMVMTVFACLMARDYMPNVKEISSPVEPLENHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V0</accession>
    <name>A0A183I6V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS15462</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042182">
        <property type="protein sequence ID" value="VDP21992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V0"/>
    <dbReference type="STRING" id="387005.A0A183I6V0"/>
    <dbReference type="WBParaSite" id="OFLC_0001547301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001547301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001547301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP21992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001547301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22665" checksum="F3F9D8DF0EBBAD8F" modified="2016-09-07" version="1">MDSLSLSNDSQTSTSLGDISYHMVPPKPPRYGTGEIHGLSVLSEPSNTRNSISDRISPRSIHDLSRSKNKLSHPSTALVLHELSNKTFAPAISGGTTHQVRLRKDPSTNSFGFSVSDGVGDNAGVFINEILPGGPADRCGQILPYDKILQINDTSLQYLDCDLALPLLQVDEIEMVLYRETDSSRNIVEDDEESLHGSINLSLRYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8J4</accession>
    <name>A0A183I8J4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043817">
        <property type="protein sequence ID" value="VDP26576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001606901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001606901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001606901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001606901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="17787" checksum="F0DCAD88ED93E1CF" modified="2016-09-07" version="1">MCVRARAWAVVGVTKGVSPGTWKGGHRDRGGGVCGVCGVAHLDAGPPELRVDQPAAAHLGAAPRELRVEQPAAAHLGAAPRELRVEEAAGRPAGPALLGFVSMGCYALGFFVAVMWVMGVCLSFSFPCHNTEGXXXXSSGSRRRRVDQLARLCLASSQWAVVWSCVPGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V271</accession>
    <name>A0A3P7V271_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003942">
        <property type="protein sequence ID" value="VDO41356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V271"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF263">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="127"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="235"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO41356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="379" mass="42565" checksum="DDDA9FAFA6BFB80B" modified="2019-02-13" version="1" fragment="single">MHVSDTTINRQTIEVLPEHDKASITILRDSINATDEQLHSVNIDKNTISINHGMIIIDMKRLQQIRMLQFKLSSKENNNDSGKKLTTNEINQITAKVMLFLSSEPIEMEHERKRQAQPRFSHPWRSDMNIIPIKLAENSPEGYTIISLPAYNPMNGSKVTDLRLSGEMAQHFTVDGRSGDVQVVIPFDFEAMEPESHIFDLQLTAGEEPYDTVAVLRVEIIDVDDNPPKITKIGDYNFENLTIAENSKPGTVLFEVQISDLDHLYGKMGVFNYALSGNGAANFQVKKINDTVAVIVSPAADLDREKIEEMIVLLKVTDSGGNSDSVAAMITIIDVNDNVPVFIHNEYKIEAVENWPEAMVLTYIHAEDNDKGLNAEIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VQ66</accession>
    <name>A0A3P7VQ66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007490">
        <property type="protein sequence ID" value="VDO50221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HIH1"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033181">
        <property type="term" value="C:plasma membrane proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017385">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038097">
        <property type="entry name" value="V-ATP_synth_e1/e2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="86" mass="9678" checksum="6262A1C80EA44055" modified="2026-01-28" version="1">MGVFIPVFTVTAFWMIVGVGGPFIIPKGPNRGIIQTMVVLTACCCWLFWVLVYLHQLNPLIGPQLPVRTIRWISEKWGDANELIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W8P9</accession>
    <name>A0A3P7W8P9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004887">
        <property type="protein sequence ID" value="VDO43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W8P9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF338">
        <property type="entry name" value="CAPSID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="357" mass="41772" checksum="0EDEB3007F7B612E" modified="2019-02-13" version="1">MKFQQNLRITYEEWNLSISPLQIICGFAALHILADGKCKEKLSDLISKALFGEIKPLGRTIHEILDELCINHLKSKGAVRIYFEENHLLAFDDELIEMVEKYYGTKYQKKSLDSEGRPKNGVVQTMCFQVNPNGQTLVNKMNKNIEEATRGNVKYVVRRDLPPKQQTRFTLVTSFDSTFYWKPSGRTMEVKIFFYDTYQKISHMRSAIKGYRCDGFLRTYLTRSGTRVVELDSEIECCKMYLFQPKKPFSKNFLESLNSKKLQYYIDQMKLERKSVIIPRFSINSPVGLRSVFASCNPLCHFIFKQKHPQFPYPCIARIFSPDKAEFGTIYGKVAQKYFGPFHIYPLWDYYHKTKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZCY5</accession>
    <name>A0A3P7ZCY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006639">
        <property type="protein sequence ID" value="VDO47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZCY5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="257" mass="28224" checksum="05F58A346761BA84" modified="2019-02-13" version="1">MVILHLNSFFSSVYGSTSNRFGLAQKNVEKGLLQQEIFTLPAPLSNHSSRNGSPCNTSTPRNSSKLMTKSPVKTVIQNEKSRSISKSTQEKSFISNTVASRTQNSCNIATKSTENCRDRGSIHVCSLPRPKQSVIPKARSISTSYSSSNSKISIPRHQSTISDTSKISQNCASSTYEKIKPQIVLIQELDKTRPAKILPLNHRNVNEKAAAVAVISKNDNEKDTVVADTENDNRTQCNNLSTVGKKKTIKQMLVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BVW2</accession>
    <name>A0A3P8BVW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040118">
        <property type="protein sequence ID" value="VDP13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="67" mass="7665" checksum="1F5CD8918B097E2F" modified="2026-01-28" version="1">MAYPSLITDSADRCSYKDDENTATKSSNISSSSSKNKRKHDGNEWDKDTPTTFKSYEDLLMTHKWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C5T7</accession>
    <name>A0A3P8C5T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040281">
        <property type="protein sequence ID" value="VDP14154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1H8"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF55">
        <property type="entry name" value="DYNEIN LIGHT CHAIN 2, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="90" mass="10699" checksum="ED2720BCB58858F1" modified="2026-01-28" version="1">MFSNKMEVKETDMESEMIEKSLAIAQEAQKHYTLDKDIAFYIKEEFERRFGPTWHCVVGKSFSSSFSYEVQNFILLRFNQSSIMIFRCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CIU2</accession>
    <name>A0A3P8CIU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041126">
        <property type="protein sequence ID" value="VDP18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864110at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="111" mass="12981" checksum="114C72381EC0C5EB" modified="2026-01-28" version="1">MGGKPLRNLLCCYHPKTEDIKDDLRPISGCYDQTYNIEQINPKQNIDLWKTNKTKKCTYKRNESPQPVEVANFKLNGAQEMLLKCKLSITYLLITWRIIIMVMTTDNRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY65</accession>
    <name>A0A183GY65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000044">
        <property type="protein sequence ID" value="VDO24839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY65"/>
    <dbReference type="WBParaSite" id="OFLC_0000017401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000017401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000017401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000017401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11990" checksum="C922891D402032D6" modified="2016-09-07" version="1">MSVDDISIVAESHRSAEQKKDRFGNVRLKRSFFSPCGQCNSSRQDRRISNQSAEATFFVRRLVHDSWLINECLSIVTYNHIVSSSVPIRRYCAILGYIAFELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY78</accession>
    <name>A0A183GY78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000048">
        <property type="protein sequence ID" value="VDO24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY78"/>
    <dbReference type="WBParaSite" id="OFLC_0000018701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000018701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000018701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000018701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11509" checksum="3B9CA461AD0602C6" modified="2016-09-07" version="1">MPTYKSAILRVCQLQLKICSKLIEIASPSCPTLLHLTTSKPSTLKRLAGRSILLHPCYSSCNLAGICCLKTEISGDIGDNNGSCYHQVLPNELIRFLRNGAVDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY87</accession>
    <name>A0A183GY87_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS197</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="UZAJ01000053">
        <property type="protein sequence ID" value="VDO24938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY87"/>
    <dbReference type="STRING" id="387005.A0A183GY87"/>
    <dbReference type="WBParaSite" id="OFLC_0000019601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000019601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000019601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000107">
        <property type="entry name" value="Protein disulfide-isomerase 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF210">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00312">
        <property type="entry name" value="CALSEQUESTRN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514008" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="506"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="542"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO24938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000019601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="630" mass="72303" checksum="B793CD8B2045D6DD" modified="2016-09-07" version="1">MLLRVILILPYLFQCVSAEESEFEQDDGIFVLNERNFMSFLQQHPTTLVKFYAPWCGHCKALAPEYAKAAKKVKVPLAKVDATIETNLAKTCFSYNIEGFPTLKFWQNGEDPIDYDGGRESDEIVKWISEKTDPTYKPPPSVVTKLTKEEFTEFITLHQLVLVKFYAPWCGHCKKLAPEYEKAAKILKDKGIMLAEVDSTVEQSLSADFNVTGYPKLYIFRNSKKFDYKGPRDAEGIVRYMLEQSEPALRKITSVKEAQRFMRKDDVTVIGFFSNEKAELLDSLNDAAEMMRNDFSIAVCLEADLKKHFEIDSDQIVIFFPEIYWSKYEPKQIVYKKAYVFSYYFPAIELSAFGNQYLQEVSTVEDLVTFIRENSTPLVGHRTKKNVATRYIQFPLVVVYYNVDFSLEYREGTQYWRKKVLEIASQYRKDKYHFAISDENEFADELAAVGLGDSGLEHNVLVFGNDGKKYPMRPNEFDGELTENLSAFMKKLSSGQIKSFVKSAPLPKNDKNPVKTVVALNFAQVVFDETKDVLVELYAPWCGHCKAFESKYKELAMKLKSESNVLLVKIDATANDIPTNYAVSGFPTIYFAPVGRKKEPIKYEGNRDLDDLIDFMKKHASVSFRSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ16</accession>
    <name>A0A183GZ16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS476</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000159">
        <property type="protein sequence ID" value="VDO25933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ16"/>
    <dbReference type="WBParaSite" id="OFLC_0000047501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000047501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000047501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000047501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6584" checksum="21AA63ED9F623FE5" modified="2016-09-07" version="1">MTCYVFSVGRSDASVKSNPSTDFYEFNCGESIFEVYFNKACKTKIDESSSDNHLLDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ64</accession>
    <name>A0A183GZ64_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS524</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000182">
        <property type="protein sequence ID" value="VDO26094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ64"/>
    <dbReference type="STRING" id="387005.A0A183GZ64"/>
    <dbReference type="WBParaSite" id="OFLC_0000052301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000052301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000052301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="8">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="9">
        <location>
            <begin position="214"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO26094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000052301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36930" checksum="BF49CC12166545E2" modified="2016-09-07" version="1">MKFENLLGQRGTAVAKRLGWKQGDEEESWSKKAIDSLMKKLQKHNKEALASLEMALQCQGRQRTDCVTIPRSLDGRLQISHRKALPHVIYCRVYRWPDLQSHHELKAIDDCRYCYESGQKDVCINPYHYERVESAGILPPVLVPRYTEPPPHIIPRLSRLHTGPSASSMPCNIDFSHYSDAMMMSKRDDEMSSNVIIPNGVTTIEVPYEERKFWATISYFELNTRVGEQYKVSSPTVEIDGFTDPTSNSNKICLGLLSNVNRNQQIESTRRRIGRGLVSQLVNFLRIYKSSRNAFCCHFKKRVVCFLHVFFLTSILPDFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ84</accession>
    <name>A0A183GZ84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000188">
        <property type="protein sequence ID" value="VDO26150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ84"/>
    <dbReference type="STRING" id="387005.A0A183GZ84"/>
    <dbReference type="WBParaSite" id="OFLC_0000054301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000054301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000054301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000054301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47236" checksum="B875D94DC97625A8" modified="2016-09-07" version="1">MKPIPGISFKDSAFSNINQIASLKPKQDEITCMSWASEDQTELLTAQMDKQLRLFDTTSNAYTTLFTLGNGTGAIKGISRTAVGTYISAIESGELSVSSPSGEVIKELNAGNNLIVMVPNCEQEGHYATGGKENPLKIWDIEKGEKIFIAKNVRPDELQLRVPIWINDIRFIPKSQNIVTVTGKHQIRLYDPRTQRRPVKEMEWAEDPLTAMSLCRNEMQIVAGNTRGDIGLFDLRNKIHMVCKYKGCAGSISGIDAHQSAEYIASCSLDRFVRLHELNSKKLVKKIYCKARLNRILLRDRLSFLNNEDENKKKMENHDDEPKVEESDNNESSEDETLWNDMKQTKERELKRKSREDDLEKVIKKSKSSRIKRKSDVTKSDTSKRKKLITRPKRKNESADETAISLPSKKLFRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZK7</accession>
    <name>A0A183GZK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS667</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000243">
        <property type="protein sequence ID" value="VDO26627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZK7"/>
    <dbReference type="STRING" id="387005.A0A183GZK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000066601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000066601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000066601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000020">
        <property type="entry name" value="Potassium channel, voltage-gated eag-related subfamily H, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000107">
        <property type="entry name" value="Potassium voltage-gated channel unc-103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="404"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO26627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000066601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="65527" checksum="5ED05C41AEFA1F28" modified="2016-09-07" version="1">MTLPGNVIKTSWICNAKRGEVQLFLIKFFLLNSKIFTAISRIHHCTILHYSPFKAVWDWIILLLVIYTAIFTPYVAAFLLREDSSRRARFSEPLEIIDLIVDIMFIIDIIINFRTTYVNENDEVVSHPGKIAIHYFKGWFIIDLIAAVPFDLLLVNTNSDEVHFPNNFLLLLNLLSTTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLLLLMATFALIAHWLGCIWYAIGSAELPHKEFTWLHQLARHLNEPYISTNGSMPTGGPSLKSRYVTSLYFTLSTITSIGFGNVSATTDSEKIFTIIMMILGSLMYASVFGNVSAIIQRLYSGTARYHTEMSRLREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNTVLKGFPDCLQADICLHLNRNLLNNCPAFAGCSPGCLRALSMRFRTTHAPPGDTLVHRGDVLTGLNFIARGSVEILKDDMVVGILGKDDIFGENPLLHEDVGKSSCNVRALTYCDLHRILRDDLLDVLDIYPEFAENFCRNLTITYNLRDEAQSMRKRIDRQRLLRMSSSLDKEKMISLQQEGYRKIPAYIWVISSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZK8</accession>
    <name>A0A183GZK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS668</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000244">
        <property type="protein sequence ID" value="VDO26635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZK8"/>
    <dbReference type="STRING" id="387005.A0A183GZK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000066701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000066701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000066701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000066701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55777" checksum="C830E72AC7A32450" modified="2016-09-07" version="1">MELRSKFSALSPTQNRIPLVSPLTTAMELRTLLSAHMICFTAESVFHFLYPAQIRLPNSAETLPSPAHYIAKQAIRYFNICAEEAAYINESMHSTECWYRMNIAVESSNPTLDKVQGWYMDERQRAIKVALTMMFEQHPPLMRALLDTGDTLLVYCSRYSSLEAELTIGMRERDLRAWLAQIDIDTRQLFDSTIRPLAFRPPYLGGNRLGLILMEIRREFMLRGVFPQQLPELQIGVEAVLGSESPAENYVSIYPFDVLDPDNFSALWINPFLLLAKQNKDSELWTQANSIKLAPKLISINETTLSAIVDELDVMEKVTEEDLENYCVEDLRAVFVRLALRMRNRLAETEAQQSEMNLLAREITAMQNMRRALEERKTQLEGGPTQERREKREPPAPLARTELPVPLMRGYSPPRKWEEKRKPIQRRYSPPEEKIPRRRSPARPKSPTPQVSRKSSPSSKSPSKQQKVTKPPIDESELSDGEILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZP8</accession>
    <name>A0A183GZP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransf_18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS705</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000260">
        <property type="protein sequence ID" value="VDO26768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZP8"/>
    <dbReference type="WBParaSite" id="OFLC_0000070701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000070701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000070701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056017">
        <property type="entry name" value="DUF7596"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24524">
        <property type="entry name" value="DUF7596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7596" evidence="2">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="YitH/HolE acetyltransferase (GNAT)" evidence="1">
        <location>
            <begin position="192"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000070701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35804" checksum="F551513E4BF5CF5C" modified="2016-09-07" version="1">MGWNSLLNRTVSYDTKMLNEVNKIPESKEENDFLTGDLGGIVSMISCAANQAYCMAVRINKSISDKYISIEPTDDPQCFQIVDDVAEDTSLQPIFIQVHHNSKRLLALQHLVDQVAERTLGRLNLDLKKNITVDLTDNDDINIWRDKAGFVIRDKVQLCELTINKNEFQKTLKTVGNVKISKFDDSQMGKLVRFDKAVSYADRKSFLEYLFRDANVLVAENDETSAVNGYGVFRKDRILAVYANAKEIAHAIMHEILRTMNHDKITLCTVRNRWNIEKSDTCCKQIIRLHTRALPTGIMWDRIYVLNVGMNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0Z1</accession>
    <name>A0A183H0Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1153</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000504">
        <property type="protein sequence ID" value="VDO28448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0Z1"/>
    <dbReference type="STRING" id="387005.A0A183H0Z1"/>
    <dbReference type="WBParaSite" id="OFLC_0000115001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000115001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000115001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF16">
        <property type="entry name" value="P53 PROTEIN LONG FORM VARIANT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO28448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000115001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13903" checksum="DEE7FF0BBB33D66F" modified="2016-09-07" version="1">MNTNVKFAVNCPILPPPKSFIRICAVYSENFYANVPVRRCDYHRSLDRNQEEHFLIVTNNSEAQHLTEKVEGEEGLRSFVIVPFDALHKNTHLTLQFRCYSSCVGGINRRQVVLCFSLENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1F1</accession>
    <name>A0A183H1F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1311</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000596">
        <property type="protein sequence ID" value="VDO29078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1F1"/>
    <dbReference type="STRING" id="387005.A0A183H1F1"/>
    <dbReference type="WBParaSite" id="OFLC_0000131001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000131001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000131001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF23">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000131001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21215" checksum="69C36D4C8F11406D" modified="2016-09-07" version="1">MLKNKAKSLLSPSKKTCCNESIVGSSEFTCCGHICLNRDTIGMQKFYLDGAVYPLEGTIEIESRCTTLPPTIEIDFRGFLTMYQIIAGLGSWARYWAVLRCGVVQFWKYPDDEISEKPALACMDLSKCTDKEIGHAPHEICSRPNAFTVDLLVPKSASLIEKKRVLLSADTKELCSAWLNALNGTLEVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1G5</accession>
    <name>A0A183H1G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1327</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000605">
        <property type="protein sequence ID" value="VDO29128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1G5"/>
    <dbReference type="STRING" id="387005.A0A183H1G5"/>
    <dbReference type="WBParaSite" id="OFLC_0000132401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000132401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000132401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="667"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="PHR" evidence="3">
        <location>
            <begin position="946"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO29128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000132401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113810" checksum="D3EA984A4EA3AA9B" modified="2016-09-07" version="1">MGLKCMFSVLYELNKRESELCAEALTSLLHLLEHIPTNALANETYASAQSMYSVLYQLRMEGSAEVSSKAVSCMIALAIAYGAPEFILLSVATLLCDKPKDLSANATPLVEVPRNYQKLANLIRRVLLRNSNEPGCSGDWWSHCLTEHAVLSSFDVRIPDNVLPNTPDDRRLTGAIASDGEYVYILACYGLFKYGTGLAETIEGKLYASNNNLKANKGSWLAVCNGALYLRRRQSCRMWVIDIDTLREIGEIMLNTSVSTGTIFTDGTTFYQATVDEQWTLMVTPLDDSFTPIQDLRQYQKFRLAELNYIAVGETYPIPHELPLTLPKSLQAQASDLQMNRDMALLLARSGIVYYAGDGTRLGLQNVGCNWMKLVLPESIVSIAVGFDTETIVLRSGSGHLWIAGVGPDAACQGSPAAGRFQKQEAGSAAVKLRKFQNLNRRRCLSVAISAGCIAYVVDNGKAYVCGRHTMQCHPETGHIYGLENVHLASIALGKTHAVAITRHGHLYTWGLNNLNQCGRTESSNTYMHQEVATGIVESELSKKAKAGEVEQSSYCLPNEHLWVKDFASICLKCGKCAPIRTERDAKGTPCTCGEGETCCLRCGLCRSCGEFIVDAFDRDMRSTPPRAALSPSRLILQRDSPEIKAKLIVSSICCGNYHTVVLAADRQVFTFGSNCHGQLGVGHVKKCVGPHKVNLPGKVQVVQIAAGSNHTVLRTADGSVITFGAHRQGQLAREGNEKNWFAMPSFVEGYGRGSGTVATWIGASGDTTLIHSQIRIYSNDIISDCQAMIFPNQVGKNYMAIRRKFNTFYQYSLGTEGLYTNWCLESKYNLLWGFNTAEMRIRSITDCIPISDKKIETDAVLNESLEEIVKEIKFLRAPEFIIPILNETSLPIKQIALNLFGIVYAATILESKRPSGQKNNQLVTDPKASNAINGRNLSCGYQRINRFDGYGGGWGYSAHSVEAIQFRTSRDIRLFGVGLYGGRGEYIAKLKLYRLCPPDYDEQNVELLSESDEMLYECAAHEKAQLLFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2W5</accession>
    <name>A0A183H2W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000934">
        <property type="protein sequence ID" value="VDO30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2W5"/>
    <dbReference type="WBParaSite" id="OFLC_0000182401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000182401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000182401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000182401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14482" checksum="73BF89837421823E" modified="2016-09-07" version="1">MDGTKKMIICDNRRQQKATRQQLVKRGKIRVDEVKVPVKPALTISHRDTHTYTHTDTNYFLKQQSPSFETNSFPIIKCIGRQLVESSSNRKLQSKMYGVTIYADHTFICNNITQAYLSTGCKLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H394</accession>
    <name>A0A183H394_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001041">
        <property type="protein sequence ID" value="VDO31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H394"/>
    <dbReference type="WBParaSite" id="OFLC_0000195301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000195301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000195301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000195301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11532" checksum="E4DF664AFC87D265" modified="2016-09-07" version="1">MRFSHVDLPSADIWRCFNSLIELHNYVHNNEVAVSNLLNILSRESFNDELIKAIINFMNTEQSYKPTIMNAISKYPPFRSLHCRLQITVSRNIIASRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3M0</accession>
    <name>A0A183H3M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001124">
        <property type="protein sequence ID" value="VDO31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3M0"/>
    <dbReference type="STRING" id="387005.A0A183H3M0"/>
    <dbReference type="WBParaSite" id="OFLC_0000207901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000207901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000207901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000207901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40271" checksum="A9B307478B26A0C6" modified="2016-09-07" version="1">MPSFFANPFMTPFMPQAAVSAIPVGSNSGTVESTQLTGPESGDYRSNPLQTGNYVMQSLQCQEMMQHYIQSLIAAASHLPGSNMSSDGATATTKNQLPLLLQRSLDDSREQSSGDSGHFQIDFPNALPALIQSMQQQLYLNNPAVSQYANSIPNLETNLTTSNVIRKIDDEKEKVNESKSFTMNDDASEEIRCEPQQMNDCNVALPEQQNGIINTDEISQDNENNHSVDIPSSNNVGKCSSSKNDENLMKEENTKKGKNSEIMIKELSSMNSSKISETIPFKTSTSSSSSSIKNIPETSLSSSSNGNNDTSTVQEECRTSVLIKKQMNEIDKEINRRIQNRNIKKVYFEFRFRIEKYLKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4M1</accession>
    <name>A0A183H4M1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2430</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001397">
        <property type="protein sequence ID" value="VDO32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4M1"/>
    <dbReference type="STRING" id="387005.A0A183H4M1"/>
    <dbReference type="WBParaSite" id="OFLC_0000243001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000243001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000243001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="285"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000243001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="525" mass="61728" checksum="DED335D333EED983" modified="2016-09-07" version="1">MQNFHLIFLDTLNDEVVPDDVAQYLIYFKRMIDEENVVEIHNLYEHGFPDLTERYFQQRLWPNEEAVENIVGSDSRIFIILYKELYFRHVYTRMQRGPSLAHRFDSYQNYQELFCEVLTPEKQPLSLQLPNVWLWDIIDEFVYQFQAFCLYKANPGKRSPEEYEDLLSIEQNQSAWNIYPVLNILYSLLAKSQIDEQLLAIREGRNPDDVADEFGRSALYFKLGYFSLIGLLRTHVLLGDYHQALKTVENLELDPKGLYNTVPSCLVTFHYFVGFSHMMMRNYGEATKIFVNCLLYIQRTKTLQQQNQQQKKNFQYDVIGKTNEQLYHLLAICLTLQPQRIDDSIQSQLYERTGERMNHMSNGNIDEFRLAFQQGCPKFLSPTTVVYEGPNQAKEPLLRQCNAFLEEIESQIMLPILRGYLKLYTTLPTRKLASFMDVSEADYDSFVGKLLSFKMIVNELGKECMDRCEIDDSTTDLDFYVDKDMIIIADTKVARRIGEYFVKQIQKLQEVKDVFISSNVNYKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Y1</accession>
    <name>A0A183H4Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001481">
        <property type="protein sequence ID" value="VDO33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Y1"/>
    <dbReference type="WBParaSite" id="OFLC_0000254001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000254001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000254001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000254001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12517" checksum="3398BC0C6AC6C7EA" modified="2016-09-07" version="1">MRSGEERYGSGTFTRATITKQRSGSKLKFFHPLRNNYPINNNQKSGHHFVSKIPQLSVAITLYFIRLEDQTEILPVDLTAGFQKSCNLAVSLLLLSDFIRFHEKRIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4Z0</accession>
    <name>A0A183H4Z0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carn_acyltransf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2552</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001488">
        <property type="protein sequence ID" value="VDO33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4Z0"/>
    <dbReference type="STRING" id="387005.A0A183H4Z0"/>
    <dbReference type="WBParaSite" id="OFLC_0000254901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000254901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000254901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF99">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000254901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14862" checksum="B84F4DE3E79DDE7A" modified="2016-09-07" version="1">MINTENNSEERLKLLKEAGEVHTFHSKECLTGKGVDRHLLVLHIISKVTGINSPLLDYYIAQPWELSTSQTPNVTRQIDEDEHPDASWFGGGFQAACKNGYGISYRFAGNHSICINIVSYKSAENTHMHSPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5R4</accession>
    <name>A0A183H5R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD_binding_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2824</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001723">
        <property type="protein sequence ID" value="VDO34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5R4"/>
    <dbReference type="STRING" id="387005.A0A183H5R4"/>
    <dbReference type="WBParaSite" id="OFLC_0000282301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000282301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000282301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057494">
        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF54">
        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25413">
        <property type="entry name" value="Rossman_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="[F-actin]-monooxygenase MICAL1-3-like Rossman" evidence="6">
        <location>
            <begin position="232"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000282301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35633" checksum="C5345C5BBE05D91E" modified="2016-09-07" version="1">MDANRLFDAFVAATSFTKIQQLFTQLCALLDIDPCDNFNVFRRLKTELNDWRAQKLWSLLEKRAEQKEYCHQKACERLSILVIGAGPCGLRSAIECAFLGAYVVLVEQRDCFSRNNVLHIWPFVIQDLKNLGIKIFYPKFCRGSIDHISIRQLQIFLVKIALVLGVQIHDSITFHRLIFPKPNENGIVEGWRAEFDPPRHILSNFVFDALIGADGKRNTVPGFPKRELRGKLAIGITANFVNQRTLAEEKVQEISGVAYIFNQQFFKDMKEATGVDLENIVYYKDETHYFVMCAKKQSLLEKGVIIQVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5Y5</accession>
    <name>A0A183H5Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2896</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001790">
        <property type="protein sequence ID" value="VDO34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5Y5"/>
    <dbReference type="STRING" id="387005.A0A183H5Y5"/>
    <dbReference type="WBParaSite" id="OFLC_0000289501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000289501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000289501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000289501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18495" checksum="C6BFC3179FCC201C" modified="2016-09-07" version="1">MYLSETMGAAEATKLDEQYNEMERKVDLTYELISALIAGTHELLQPNPATRAKMATMGALSKVRGTSKVQPYPQTEGLLADTMQKYGTALGADSDLGKALIDASEAYRQLADIKYQMEDNVKHHFLDPLAHLQQTDLKEVNHHRTKLKGRRLDYDCKKRKQTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6B4</accession>
    <name>A0A183H6B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3025</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001897">
        <property type="protein sequence ID" value="VDO35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6B4"/>
    <dbReference type="STRING" id="387005.A0A183H6B4"/>
    <dbReference type="WBParaSite" id="OFLC_0000302401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000302401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000302401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000302401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18724" checksum="095304244E6CF2A8" modified="2016-09-07" version="1">MQVNQNPVYQIYATLIAFYGPTCIMIILYAKMWLAAKRLAARDRMLIIGTDGSINGTNLTNKLHSSANLSDPLNQNHYQHHHYDRPSAILQKISVVHINKFQEKSEGKARKTLGIMMSVFVICWLPFFLLALLKPQGLLPPRWLDHLALWLGYSNRFVRCFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6F1</accession>
    <name>A0A183H6F1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3066</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001933">
        <property type="protein sequence ID" value="VDO35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6F1"/>
    <dbReference type="STRING" id="387005.A0A183H6F1"/>
    <dbReference type="WBParaSite" id="OFLC_0000306101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000306101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000306101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000306101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="47267" checksum="CD3C389325FB0C83" modified="2016-09-07" version="1">MVPLNHFKENISPEFSLHARFDLHTGMILATPNEKKYGHLQMDLIALYLLALVQMTAAGIQNLVFYIERTYRTPDFGMWEIGSRYNVGERELHASSLGMVKAALEAINGFNLYGTAGTSSSVIYVDIDGHNRNRTTFETILPRESNSKNTDAALLPSIGWPAFATHDAQLYERTFDKCIRRLEGRYGLKRFLRDGYHTELEDASKQYYDEHETSRFQNIECQFPVFFAYIAITAHFRGERKLSNSYWEKAKDMLVSNEKTSYLVMPECYIIDEEHMHDERMNPNSQEFYPASPYEFGHHLWSNAVYLIALLLKDEYIHSTDMDPICRHLPASQRPKYQNRHSVFQRDMEQANGSSSMEGDPVVQVVLIAESSRLQMMLSTYGIDTQTPHDLEPVRIWPSWKMVKVCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6W0</accession>
    <name>A0A183H6W0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3222</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002088">
        <property type="protein sequence ID" value="VDO35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6W0"/>
    <dbReference type="STRING" id="387005.A0A183H6W0"/>
    <dbReference type="WBParaSite" id="OFLC_0000322101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000322101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000322101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000322101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14202" checksum="04A8B96316E23BB2" modified="2016-09-07" version="1">MSLFKKPTKKKQRHLRERLIDEDTEEDEAEIARKFRRKLDGVKELQESRARKNGLNAVECALGKELAAEFIAMDDDPFRQRGGGMLRLSEGRQAQMHAADIEAGIRDQFKKESFLRDEHEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H873</accession>
    <name>A0A183H873_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coiled-coil domain-containing protein 22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3686</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002555">
        <property type="protein sequence ID" value="VDO37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H873"/>
    <dbReference type="STRING" id="387005.A0A183H873"/>
    <dbReference type="WBParaSite" id="OFLC_0000368401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000368401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000368401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008530">
        <property type="entry name" value="CCDC22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048348">
        <property type="entry name" value="CCDC22_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668">
        <property type="entry name" value="JM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05667">
        <property type="entry name" value="CCDC22_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 coiled-coil" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000368401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17595" checksum="823D886CC3DCCC1A" modified="2016-09-07" version="1">QINRNIYTKHIFDIVGNIRKQQNEINKVCSSNIIAVENLCLQKEIKSNAGKLERSFTVVEGKLYKDVEKDASMQKAYRLLMKIHGEYSSVITGIDFSGQLEREIEELNDQIAMQHQKNIDEKFERIVNDWMEIKKENVALKELLFKKYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8C3</accession>
    <name>A0A183H8C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DWNN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS3735</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002603">
        <property type="protein sequence ID" value="VDO37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8C3"/>
    <dbReference type="STRING" id="387005.A0A183H8C3"/>
    <dbReference type="WBParaSite" id="OFLC_0000373401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000373401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000373401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000373401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23323" checksum="D598F8A33E9083EB" modified="2016-09-07" version="1">MSSIHYKFKATLEYKTLVFDGLHISVIDLKKEICEKENIKAESFDLVLTNAHTKRQYTRDELIPRNSSVIVQRIPRDNAAKLPKVQDTTNSGIVTKPTPAETPVVGHIDSEEFDKMTEEERMAHVKEVSTYKYLPSNFQKKTSSIMSGPPPPTYVCNRCSQSGHWYKNCPMVTVILYLYFYVILFNIHRKDLLFHMYTFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9C9</accession>
    <name>A0A183H9C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2185 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002977">
        <property type="protein sequence ID" value="VDO38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9C9"/>
    <dbReference type="WBParaSite" id="OFLC_0000409001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000409001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000409001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000409001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28465" checksum="23A2F7B79B810DDB" modified="2016-09-07" version="1">MRNCQQLSSFVHCCFITADDNTSFLHEGTHCFRQRSTDLSDHFYKKNMRMTHTWQTLSNDDTVVLLQNMADGYSILDTKYGISMPILDNEDYANLTPMATFFGMDNVKELTVLAQDDYKFYICEYLRDSEHRFLLQECYESALLKLENPSHVKFCANPIYQAIIQFNNAYTNIKWQLQVTYTTINGFNDNNIYIVESVDLITDQQVAMICSPFNIDIYMISSNVLVHYAIDLPKIDGETLIGNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9J2</accession>
    <name>A0A183H9J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4154</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003047">
        <property type="protein sequence ID" value="VDO39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9J2"/>
    <dbReference type="WBParaSite" id="OFLC_0000415301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000415301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000415301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF8">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000415301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30942" checksum="A79091663E391C4E" modified="2016-09-07" version="1">FRHRLEINEHGVYQSSFGEYGRNRPLLKSAISFNKQQKYHQNQQQHQQQSQNNSYISTDQLEMPQLKDSSLHSFAGIYKSSKNAVEFASNFEQYLIFCLPSYVWIGLMFLLILWGLVQIIVGTTNLPFCPSRPMIPVFLIIMGCLYILWGMLRIYAFWPRSRVDTLSVDLTCKALEGVMIVAMLVSLFYGRLMRDKYCHSPGCIWIYGPEQNTHFERAYFQSHYCNRFAYWTAFISAALHSIIILLAFLFLFCLLCVALLNENKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA74</accession>
    <name>A0A183HA74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS4386</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003303">
        <property type="protein sequence ID" value="VDO39829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA74"/>
    <dbReference type="STRING" id="387005.A0A183HA74"/>
    <dbReference type="WBParaSite" id="OFLC_0000438501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000438501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000438501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO39829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000438501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31050" checksum="84459926EEA63D0C" modified="2016-09-07" version="1">MACKIAYYCPEYFKYILNKFSVIYGIIFNILNYAIFPGVLTQVQAFFSIDDTGAGLLQTVFIIFYMIFAPLIGFFGDRYNRKWIMITGIAIWVLAVLASSFVPANSFWLFLLLRGVVGIGEASYSTVAPTIIGDLFTTPIRSRAIMFFYFAIPVGSGMGYIVSAIVASLFGGWQWGLRVTPILGVLCIIFVILGMKEPKRGEAENAFPNNVKQTSYWEDIKAILIIPTYVYTTFAYTSVVFVTGTLTWWGPAAIEHSVAMQQNLNSTHELSNEQKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBC6</accession>
    <name>A0A183HBC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen [starch] synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4789</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003816">
        <property type="protein sequence ID" value="VDO41044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBC6"/>
    <dbReference type="STRING" id="387005.A0A183HBC6"/>
    <dbReference type="WBParaSite" id="OFLC_0000478701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000478701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000478701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000478701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9316" checksum="0A45D803C609052E" modified="2016-09-07" version="1">MTEQGHMLRSLSRSKIEMTLAGMNLDQSKLIRMDGGQTARREGRSVFECSWEVANKVWNSSTNPHKSAYTYRIKIKTFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBP7</accession>
    <name>A0A183HBP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EloA-BP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4911</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003972">
        <property type="protein sequence ID" value="VDO41419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBP7"/>
    <dbReference type="STRING" id="387005.A0A183HBP7"/>
    <dbReference type="WBParaSite" id="OFLC_0000490801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000490801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000490801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA exonuclease 1 homolog-like" evidence="1">
        <location>
            <begin position="147"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000490801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38396" checksum="9802A8D6B12C8649" modified="2016-09-07" version="1">MVPAAKKQKIINNDLKLKADSISKKMANQKEMETKMEEKKQIAYNSNNLQLNKQMCVTTNKVRAPTMAQQLMDRYQKLQKARDDFFKNLKFDGEIDAKKITTAEKKYDYKSGAVAATNSKGEKRVAHAPKISKSAEVNLIPLDPYSCSKVPYALRAHYLNLFYIECQKFCDSSNDAITQAQQEEKAIKDRAVTKGGYTSAAVNVLRRLRDVTSSQAAALKSVSHSAILAGRHHGSITVGQRKYSSSGKQTINERLLLSKFVLDEQKMEQNGFPLWEDPDKKRVKIKTSELDSKKKLFVEESDLKRICCRCGTEFTLTPKGEYAALKQCVYHWGKAYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBX6</accession>
    <name>A0A183HBX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4988</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004076">
        <property type="protein sequence ID" value="VDO41689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBX6"/>
    <dbReference type="STRING" id="387005.A0A183HBX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000498701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000498701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000498701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="101"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000498701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26752" checksum="605379214013E3CA" modified="2016-09-07" version="1">MISGTLESSDGNSIVLDEELASEKDAISELIEGELPEQSISKDEEAVSVEKPTSLLNELILPAEPTSAIVDAIDDIPLETDELGAEGCFTTVDTTEKKPGSRVQIRNMPTYLKYKQVKELLSKQLGKFVVKNIRYTGITVFFSLPTPEEAAAAVHIFDGFKIKGHILRAKIAQPEQLKVKPLNSDQIKRTARERVTPLADKPYSEQLEIKMNDVKRIAKNFLKEMIDARVNSANKINVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBY1</accession>
    <name>A0A183HBY1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS4993</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="UZAJ01004080">
        <property type="protein sequence ID" value="VDO41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBY1"/>
    <dbReference type="STRING" id="387005.A0A183HBY1"/>
    <dbReference type="WBParaSite" id="OFLC_0000499201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000499201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000499201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000499201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="51283" checksum="0AC5994C365E2192" modified="2016-09-07" version="1">MLQFDLPKKGLVVVGDLHGDLYCLLNILLKNGFPPNANYLFLGDYVDRGLYQVQLILFIFLMKLRWPNYVTTLKGNHEDYQCGKEYEFYDQCMRMFKRGRRWYTLINHVFDHMPVCAIISDHFFVCHGGISQWMTCRSNIRNIPKPTYTNDMYFIEGVLLADLLWADPVPQQKKWFALSQRNCGYTFNRYGLIQVLRSMKLTTLIRGHEYYRGGTARNFGDETCYTVHSTTDQQGLYEPYSGTLTLEKMADTFVVVENNELIQRNGNAGQLARQAQMEMQHSFLETVISYNHKTCHWCEQPYPLYVTRRKRCFMYNDILDYMMKNGQFVLFAANLCGKLSWRGTFWRAMKRAIDLFPMTLDMIFGKSDDDDFPRTFRVCISEEEYKLMEKIYKAKGIDMEFLMPKFQTISDVHMELQMPTSRFQKLKRHIKLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC59</accession>
    <name>A0A183HC59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SprT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5071</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004171">
        <property type="protein sequence ID" value="VDO41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC59"/>
    <dbReference type="STRING" id="387005.A0A183HC59"/>
    <dbReference type="WBParaSite" id="OFLC_0000507001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000507001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000507001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="147"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000507001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="48358" checksum="8C7F9DBDAB95EBAF" modified="2016-09-07" version="1">MSDSESIIECSSECDSNSSDKSDHGVLKNIGDGKIRHHSPPKNVNNEHAAHWHYPVTESNILNTRNFINLYFSLLLKKLILSFPYYSEKMKQSEQANLVLGSRSALNIQKEHHQDDDELFLLALSQNRPAHANAQKYIAAKFPRIRKELTAKLFDLYRRRCFKNKLDSNMVLEWNSRLRLTAGRCRCKPNGTASIELSIKVCDTPGEFIDRSLCCSKQIKIIISHAKGDISWNKGIMLDKINLFVERLRDTLLHEMCHAAVWVIDHIHNGGHGPAWKYWAYQCQKIFPSLPLIKRCHNYIIDAKYLYICDRCGQTIKRHSKSLDIDRKICGICQGHFILRSRDGKEFSTKPANTFAKFVKENYRSERKPGVKHAEIMKILSLRYKEAIIYFKITSWNKICYIVYMQQHRKYLYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC91</accession>
    <name>A0A183HC91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004215">
        <property type="protein sequence ID" value="VDO42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC91"/>
    <dbReference type="STRING" id="387005.A0A183HC91"/>
    <dbReference type="WBParaSite" id="OFLC_0000510201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000510201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000510201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000510201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20642" checksum="D52CFF3BAA1F0F24" modified="2016-09-07" version="1">MISNLPDCKELLCYSCNSQFGPCDGNGCSTSNGFCVYQQITSADGNILSTVRSCLDGDRVPAGPLHVIQAGQCTETVDSNTGIRYRTYLCNNYNYCNADCHPQLPTVTSDPISPTRASALECFNCNSFGMDCYSNTCTINNGGYCFFQFSNISVNGINHLHYNKQCIEVPFAKTPNGNSVTEINKCVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCR6</accession>
    <name>A0A183HCR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5274</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004449">
        <property type="protein sequence ID" value="VDO42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCR6"/>
    <dbReference type="WBParaSite" id="OFLC_0000527701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000527701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000527701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026164">
        <property type="entry name" value="Int_cplx_su10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21045">
        <property type="entry name" value="INT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000527701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42044" checksum="EEADD4D486452611" modified="2016-09-07" version="1">MHICKWKIQLDSVLGKFISRNSIGEVLAWIPEDNWAMDVDKLLNSNPECSTPSKKTKFKERKEEVATFQTDYLISSRPELCEAYELCCAAICEYITSISIDVVDENLYFASFYSDIRQFITESLLFKCKVNELIAYAGDVSTVKKFQIPGNNDFWTKDVLYFQLACAHCIDRNWPDACENVIHMFDMSTKDEIGSEMPTFIIIKKERLRRIVYDIAYHILFRVYTSTAMDHDNDQLLGALLVLSQIDFATKGYRCFNRIMRYVEAKGSLRSAGLVKYITNIAILEELSRIQDYCCEYVSIQIAVPQVQRRIGQSTRHSVRGTKDGQKQSIEEQIKKCQEDPYVTVSTYFTENKEAIMKMLGAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCU6</accession>
    <name>A0A183HCU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004493">
        <property type="protein sequence ID" value="VDO42708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCU6"/>
    <dbReference type="WBParaSite" id="OFLC_0000530701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000530701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000530701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000530701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3767" checksum="86D5F92CBAD27A8A" modified="2016-09-07" version="1">MQQNAVSELYYWIHFWIPILHQFKFRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDN2</accession>
    <name>A0A183HDN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5593</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004884">
        <property type="protein sequence ID" value="VDO43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDN2"/>
    <dbReference type="WBParaSite" id="OFLC_0000559301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000559301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000559301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000559301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4480" checksum="A96788380192A02F" modified="2016-09-07" version="1">MHEDKYVSNVRQPSEGPSEGPVTLMGRIAGKNQERDRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDN4</accession>
    <name>A0A183HDN4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5596</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004888">
        <property type="protein sequence ID" value="VDO43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDN4"/>
    <dbReference type="STRING" id="387005.A0A183HDN4"/>
    <dbReference type="WBParaSite" id="OFLC_0000559501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000559501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000559501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000559501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47320" checksum="2ACAF6A977972892" modified="2016-09-07" version="1">MRDIAAIRFFLGSLEDDSSDDDENESEEEDQKTLKQVVVAYKAAKKTRKKKEKFMKAKKLLNTDRKSKKENAGKFCNLLAIRYIYDPQTFAERLFGLLESRKNEKFETRLLCMALCARMIGIHKLQILSFYSYMHRFLQPKQREITRILLYVAQACHELVPPDIVEQLVYVIAQNFVCDRNTPEAMTVGLNTIREIFATCPFGATEDLLRDLTDYKRFKNKNVSMAARAIITLFRAINPKLLHRKDRGRPTETLKDLKIIEFGAEHPEKFVEGAECLPMEVDVLNASLMQNDESDDIDFDFDAEFVEKNSLDLDGSVDSFNNHLAICTDNEKSPNNAIYEMNDQKTTFFETKEKARQICEARILTQDDFCKISAFRLKQQVRCDEKRRNNDIKLEELGETIAKYFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE18</accession>
    <name>A0A183HE18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005088">
        <property type="protein sequence ID" value="VDO44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE18"/>
    <dbReference type="STRING" id="387005.A0A183HE18"/>
    <dbReference type="WBParaSite" id="OFLC_0000572901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000572901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000572901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000572901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13334" checksum="9CDB8BA4D5175606" modified="2016-09-07" version="1">MAAAATTITASESLRSSRKTMDTIISDQEFRSTSLPSLPLNLSKNVNNYQYENDSNTLQKAVSSSNSKFVLQNNCFNQNASTEDVEVLQVMLNKIIALIEVATLNLKTERELIENEKCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFL9</accession>
    <name>A0A183HFL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005876">
        <property type="protein sequence ID" value="VDO46012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFL9"/>
    <dbReference type="WBParaSite" id="OFLC_0000628001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000628001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000628001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000628001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14478" checksum="4452A702E34D8E06" modified="2016-09-07" version="1">MQTTVVTTIASDTKQSIPPERRNGMAGSATAQANENTKRNHDGAEEGSAHLSTSVESFEKVLPSENKISQQIKPIHHISDQLMPNRTVESDYAKSRTKSPERQRRQSNRSFDDQNRRYTFHLFPFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGH8</accession>
    <name>A0A183HGH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006352">
        <property type="protein sequence ID" value="VDO47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGH8"/>
    <dbReference type="STRING" id="387005.A0A183HGH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000658901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000658901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000658901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000658901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23598" checksum="C1FB39AB01A6B7EB" modified="2016-09-07" version="1">MLLTLLGNVLVTFYRSKNVDMSLRIASLDYLGTVTASLRKDMQQSVSDDVRLDVVVKTLLYEKLKEEEQTGDIDTIDISHMSSVDKMKKVQRALIDYLVERKSDADVSIEYAIMFYVGIWYKEVYEEAESTKQKLKQILNNSEINDKEKRKFEKKSARVLERCQAMKIFFIKTADEKHMRKRAEQIAYVFLMNCLNEIVTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGM0</accession>
    <name>A0A183HGM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6632</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006418">
        <property type="protein sequence ID" value="VDO47221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGM0"/>
    <dbReference type="STRING" id="387005.A0A183HGM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000663101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000663101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000663101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000663101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41189" checksum="2D1DF13E0F45CE4D" modified="2016-09-07" version="1">MKPSTKAELLTDGSISSTGKSISHEDEQKRSKESFFFPTKKQQLSKEIDSDSKIQQIDHPTSSFMMKKTAAPSPKPISPPIIYPPTPPRSPRTKKKRKRIPDSPQKGKLATAILPDGNLYHNFYFAIIMKFFDSRIYFGMSSSSDESDSSMEDEDIMWRSVSEASPNAFISHQQISKSKESSELFGIIQSFDKNNDDKSFSIPTASNISDQSDQSVTTGSHYPDKPPLTAKKLKALSLLKGRQYRFGELPKKFLDVRSAEISSPKISSTTDSTPSVTKEEATDLKVSSADVLVKPKKKNLYVVSENEKKRKFGLLPPTPSLLSISSQRSSKSRSKEIVALKTAISKVFLITFFITFNFITIEILMTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHB5</accession>
    <name>A0A183HHB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein Nup85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6874</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006806">
        <property type="protein sequence ID" value="VDO48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHB5"/>
    <dbReference type="STRING" id="387005.A0A183HHB5"/>
    <dbReference type="WBParaSite" id="OFLC_0000687601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000687601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000687601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000687601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29917" checksum="01F49E29D17FFC98" modified="2016-09-07" version="1">MLAELGSEKAIFICYSSLSSSFLEQELRVRILWSIAINGTSTFPFQVCKNHLWMLLATLKSNYNSEIKYQSLINGYELINLETVQNLIAEMERRESLEAIQRLFDSRQFDRVVDIIIDNFSWKDVDRSALLSTAMILIDSYLQLNDMNGASEWISRLLDFTGGLAGTQEVIERVKQLAIENISIENISNLVHCIVHLLVLGGYESDTALWLVLYRCAFHLEGEHTVETLSELYDGGCQMLTSALNILVTAHEAIAKHGKCFIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHU7</accession>
    <name>A0A183HHU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007121">
        <property type="protein sequence ID" value="VDO49133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHU7"/>
    <dbReference type="STRING" id="387005.A0A183HHU7"/>
    <dbReference type="WBParaSite" id="OFLC_0000705801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000705801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000705801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000705801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24846" checksum="7973FB1F73AF5A0E" modified="2016-09-07" version="1">MTGQVSDYLLQKLIKQSKYTRKMRTLQKKHIDFVKCVRDGCQSLAGTKPPIQEVPYIWTTTICSYPFFLVDLSKVQGFSVCFENMSEEEIKTAKSSAAVSDNEYPKILESYRQKWVRNLGIQNKPSVSCQKISCQKNKRIHTSCLKILDRCPSGLRNNDLEAVLTMFCEREECDFDESYASILEMLVPLRCTLDELYNIFYAITTKFVPRFFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIT0</accession>
    <name>A0A183HIT0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7397</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007701">
        <property type="protein sequence ID" value="VDO50809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIT0"/>
    <dbReference type="STRING" id="387005.A0A183HIT0"/>
    <dbReference type="WBParaSite" id="OFLC_0000739101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000739101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000739101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO50809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000739101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21342" checksum="46A88938F8E1A8A0" modified="2016-09-07" version="1">MKILSNINFFFFRQLFRVSGVKSIFFGENYVTITKENEIDDWALLKPEIFAVLMDYLQSEKPIVNEGDMPKNPEDTEIHPEDSDTVAMIKELLECRIKPMVQEDGGDVIYKGFHDGVVHLKMQGSCTGCPSSSVTLQSGIKNMLQFYVPEVKDVIEVKDEADDVLDSAFDDLMGKIKVKPNPNEQNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIU1</accession>
    <name>A0A183HIU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1897 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7402</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007712">
        <property type="protein sequence ID" value="VDO50832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIU1"/>
    <dbReference type="STRING" id="387005.A0A183HIU1"/>
    <dbReference type="WBParaSite" id="OFLC_0000740201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000740201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000740201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far upstream element-binding protein C-terminal" evidence="4">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO50832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000740201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="24847" checksum="27D7080CA3963D9F" modified="2016-09-07" version="1">VGDIAPGTPVPQLHGQGGPGAGGDAFGVAHNTVPSAPQGYGNGNAQFAGAGIAGQAGAQWNTTFAHQQNDPGQAAWNQQYYGQQGQQQPGYQQGAYATQYQQPAQPQPQPAQTSVAPAVNPQTEKAEISMNVRGFTFEATQGIIYLYHEAAPLPLAQWAEYYRSMGMHEQAAVIENQLKQNAAAAAVTQQPTAQARPQQPGYGAYGAQPITAQNQFSYGAPQAQPQGGYQFQQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJL2</accession>
    <name>A0A183HJL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7674</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008174">
        <property type="protein sequence ID" value="VDO52136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJL2"/>
    <dbReference type="STRING" id="387005.A0A183HJL2"/>
    <dbReference type="WBParaSite" id="OFLC_0000767301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000767301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000767301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO52136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000767301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15040" checksum="4C51D7E3E8A763E7" modified="2016-09-07" version="1">VRGGAFDQAIESETPFGFGKGEGFDKGANESGWIVARERYKADELFDSLDPIDGKITGRAAKEHMVKSKLPNAILGKIWKLSDVDKDGMLDSDEFALANYLINLKLEGHELPAELPKHLIPPSKREEDPIYPTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKC7</accession>
    <name>A0A183HKC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7939</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008633">
        <property type="protein sequence ID" value="VDO53261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKC7"/>
    <dbReference type="STRING" id="387005.A0A183HKC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000793801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000793801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000793801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000793801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19822" checksum="218A2DB410639061" modified="2016-09-07" version="1">MTATTPATNLNTNDDYVLDIALLNDSLAVRQAGLTVQKHRNGHYRSQRYFNENASCERRNKRNPYTTVPDISASREKLIAFDATNKSVGSENDSFISSNISPVHPNEITNNGYRRNDDTDSDETTHGSSLIRPRHTRPPRKSKRRTTTDREQTAITCPDAIVAPSSSGYQSQNHSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKM3</accession>
    <name>A0A183HKM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF4604 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8035</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008800">
        <property type="protein sequence ID" value="VDO53740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKM3"/>
    <dbReference type="STRING" id="387005.A0A183HKM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000803401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000803401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000803401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="3">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO53740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000803401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18002" checksum="EFCA9D91BDC14D2B" modified="2016-09-07" version="1">MSGKKLSYKEKSSITAIVQEDPPFIQKIKEKLGYKPPPTIENKFSTTAGEGYIENDQDDDDLSQMNQEDRPQIVILDAQKDLDEKELEAELEKKRIEEDRKKIEEGKIIFKKPMKRKEQDSGEETAEKRRHSEEVKEIAVSNSRLLSFNDEEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMH3</accession>
    <name>A0A183HMH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8685</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010025">
        <property type="protein sequence ID" value="VDO56892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMH3"/>
    <dbReference type="STRING" id="387005.A0A183HMH3"/>
    <dbReference type="WBParaSite" id="OFLC_0000868401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000868401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000868401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF147">
        <property type="entry name" value="RNA-BINDING PROTEIN ASD-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO56892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000868401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="23884" checksum="ECFFD8C03FE8CA6A" modified="2016-09-07" version="1">MLIYNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKAKEEVNRGKPNWEHLSEELHVLIQCDDTPNRALLKLKRAAAEVKKLLVPSSDDDELKRKQLMELAIINGTYRSGNINHAAAAQAAAAAAVNKNSLAALQARLMAPLPLAATQPNNLRSPGLTGAPIILSPSRGAAPTAATAAAAALAAQLQAVANQQQNVAAAFTPQGPAVAALPAQLLQNPTLAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPM6</accession>
    <name>A0A183HPM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011559">
        <property type="protein sequence ID" value="VDO60587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPM6"/>
    <dbReference type="WBParaSite" id="OFLC_0000943701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000943701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000943701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000943701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6429" checksum="2C8C9E4D7CDADB7B" modified="2016-09-07" version="1">MGSSIKISKKKGEKKDRFLYSLLTGLASWGLSDTTANGDSSHYINCNLEALGKVRPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ01</accession>
    <name>A0A183HQ01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exocyst subunit Exo70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9562</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011853">
        <property type="protein sequence ID" value="VDO61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ01"/>
    <dbReference type="STRING" id="387005.A0A183HQ01"/>
    <dbReference type="WBParaSite" id="OFLC_0000956201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000956201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000956201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000956201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22917" checksum="77F780B49478E56F" modified="2016-09-07" version="1">MIESITERYRWIESLDVQSQFLNVQIFMLDDFRLRLVHISQQLSSPWQKPFIQILNSAWYIAYVLDEWNEVDIFIRIQALGKRAHFRGVFEDVANMYRHLWRQRAEDLASAFFQHIRVSLNRYQHEKWYSWEVSKPLDLTSSFCPFLLEVRRLLRHVNDAISPHSATKLYEMLNEKVAQLLLEMVTTVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ37</accession>
    <name>A0A183HQ37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011944">
        <property type="protein sequence ID" value="VDO61801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ37"/>
    <dbReference type="WBParaSite" id="OFLC_0000959801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000959801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000959801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000959801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23808" checksum="FD726CFD6E793422" modified="2016-09-07" version="1">MATIGTLNGIDLQTDDAIMNAHRNLVHGDDNNSWSILTKQPILSTGIYSGNNSVTSFIDQSTKYRPSSIAELTKINSTIDSSCCANTTESFTYHMPSSSRNLVSQKPNPYAEVSLSVFNSFGSINSRTGDGSSNDRSVIDRHGTDVSTCSTCSTDTVTCSVCQDCGESTLTERSSWNDSSSVQSSTVSDRTIQQLVLIFSKFYVFRFNCSYLYSLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSB9</accession>
    <name>A0A183HSB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10385</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013783">
        <property type="protein sequence ID" value="VDO68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSB9"/>
    <dbReference type="STRING" id="387005.A0A183HSB9"/>
    <dbReference type="WBParaSite" id="OFLC_0001038001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001038001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001038001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001038001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10081" checksum="92A20D9357919814" modified="2016-09-07" version="1">MSNDVSSNDNDPYKEVIRGGLKLKKGKSKFKKKKKENVDVKNIDITIHKDADATVTYKTPAEIAFEKRQLQNQVRIVFFFFLNLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUG3</accession>
    <name>A0A183HUG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS11122</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015653">
        <property type="protein sequence ID" value="VDO74030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUG3"/>
    <dbReference type="STRING" id="387005.A0A183HUG3"/>
    <dbReference type="WBParaSite" id="OFLC_0001112501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001112501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001112501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="72"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO74030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001112501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18170" checksum="2D38B244F9038F8A" modified="2016-09-07" version="1">MAIFESNELIVEETNRKYEKGLLSYTNALNHLADLTDEEFNMMNGLSLSNETYLQGGKEIVKLYKYDRNEKLPAAVDWRKKGLVTSIKDQGECGSCYAFTAAAALEGYYKKKKGKLIDLSPQNIIDCSRKYGNNGCENGNVPSVIFLYTCFCKHTSKFCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUU2</accession>
    <name>A0A183HUU2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11252</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01016030">
        <property type="protein sequence ID" value="VDO75117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUU2"/>
    <dbReference type="STRING" id="387005.A0A183HUU2"/>
    <dbReference type="WBParaSite" id="OFLC_0001125401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001125401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001125401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF51">
        <property type="entry name" value="GLUTAMINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO75117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001125401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19135" checksum="8F0BC1F624AB6F81" modified="2016-09-07" version="1">MNSIKLLDTDTLDLYFQLCAIETNVDTLAVMAATLANGGVSPLSEERVVCNRAVRDTLSLMYSCGMYDYSGQFAFKVGLPAKSGVSGDMIIVVPNVMGICLFSPPLDQLGNTVRGVKFAEQFVEKFNFHNYDSLVYSETHKIDPRKKIREVKHESVSNMMYAATTGDISSIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV08</accession>
    <name>A0A183HV08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016215">
        <property type="protein sequence ID" value="VDO75594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV08"/>
    <dbReference type="STRING" id="387005.A0A183HV08"/>
    <dbReference type="WBParaSite" id="OFLC_0001132001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001132001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001132001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001132001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6868" checksum="72A9536DA910532E" modified="2016-09-07" version="1">MEWEISESYRAAKEAALRRKYDQSALFLRTALSLIERRLNSISVDDPSKGQLVKVRHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV37</accession>
    <name>A0A183HV37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epimerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016311">
        <property type="protein sequence ID" value="VDO75834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV37"/>
    <dbReference type="STRING" id="387005.A0A183HV37"/>
    <dbReference type="WBParaSite" id="OFLC_0001134901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001134901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001134901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001134901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15507" checksum="821CA1904C58982B" modified="2016-09-07" version="1">MDYHTFPAAPKVSLGMVDVRDVARAHIRAMECESCDGERILITAIPSIWFSQLTRWLYEEFKDQGFLISRVISPNWLAKLYAKATCDPHFEAIKYRFGPKLHFDNTKVKKRSNKLFKIAFFRFFLNINSGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV77</accession>
    <name>A0A183HV77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016399">
        <property type="protein sequence ID" value="VDO76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV77"/>
    <dbReference type="STRING" id="387005.A0A183HV77"/>
    <dbReference type="WBParaSite" id="OFLC_0001138901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001138901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001138901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001138901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12908" checksum="608F04C0DDCC58FF" modified="2016-09-07" version="1">MGTMGVISSVFSAMMDSVWSGLFSVLRPQQFLETFAVEVNASLADGQQHDAQEFQIYLLDALHEDTNRVVKRVTFEQNYTGADLKAEAIDYNEKLRKFACSPISDIFNVSHFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVK5</accession>
    <name>A0A183HVK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11518</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016703">
        <property type="protein sequence ID" value="VDO77032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVK5"/>
    <dbReference type="STRING" id="387005.A0A183HVK5"/>
    <dbReference type="WBParaSite" id="OFLC_0001151701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001151701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001151701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000084">
        <property type="entry name" value="Glutamate-gated chloride channel subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO77032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001151701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24917" checksum="733BDE5C36B3A7CB" modified="2016-09-07" version="1">MAAYCSTVAGEYSCARVLLLLRREYSYYLIQLYIPCIMLVVVSWVSFWLDKDAVPARVSLGVTTLLTMTTQASGINAKLPPVSYIKAVDVWIGVCLAFIFGALLEYALVNYYGRQEFLKKEKKKKTEYKGCLCPSDQLLNQDLRHSLRLDKNAYRRRWWTKFWLNTYHCGNVEVSKRVDLISRFAFPTFFACFLGEAYFYIHNLFDWFICCSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVR4</accession>
    <name>A0A183HVR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11579</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016877">
        <property type="protein sequence ID" value="VDO77513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVR4"/>
    <dbReference type="STRING" id="387005.A0A183HVR4"/>
    <dbReference type="WBParaSite" id="OFLC_0001157601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001157601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001157601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001157601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31479" checksum="6032B0CF73577DD1" modified="2016-09-07" version="1">MQTIQPSKLDLDIYESIESVSSTGTIVQPEQNVQQSISCYQDIPIYSQQRKTVETESVLRFLLNVPEFLVSHKLPPTVVDGNYCFVIDRETIGSEAILHEDIHWSHTSRPTQYFYFDDLRNFYRVNCTKAKGKIMAVKISSSQKRAFSLLHSTRSTPMSQSRSLSRRSISSTSGFRRDLIPLKQVYLVTRIYSFWKTCPSFRRIITLIDRVNDNEMENIQFQKRMFVQYIWRDTKQSEKDRVKYEFNRDCAKGVRFGTPKKLMKFVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVS5</accession>
    <name>A0A183HVS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11584</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016903">
        <property type="protein sequence ID" value="VDO77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVS5"/>
    <dbReference type="STRING" id="387005.A0A183HVS5"/>
    <dbReference type="WBParaSite" id="OFLC_0001158701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001158701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001158701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001158701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16351" checksum="E45EB91C7C9EDFFB" modified="2016-09-07" version="1">MGNFNNTEYATINTLMPYAAWLIYATVLLMLAATIVHYLSINAMGSGVPEVKTILQGVHLKKHLTFRTLISKLIGLMLAIGSGFPLGKEGPFVHMGSVVAHQMRRLVEGNKPVYANESRNYELLAAGCAAGVAATFSAPVGGSLLINHPIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW38</accession>
    <name>A0A183HW38_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS11698</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01017240">
        <property type="protein sequence ID" value="VDO78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW38"/>
    <dbReference type="STRING" id="387005.A0A183HW38"/>
    <dbReference type="WBParaSite" id="OFLC_0001170001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001170001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001170001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001170001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14819" checksum="504E71A45D68B1D5" modified="2016-09-07" version="1">MTNYTTASAGLYPAVFSSQSAKQRDARLKKFEFIGRLLAQALIDSRMLDIPLNPVFFKWLCGEDKMFSLSDMEIFDKSLYQSLRALILTDPNDFDSLEQYFTLPGDENFELIKGGKNRLVTSSNVVQFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW59</accession>
    <name>A0A183HW59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor-knot domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017300">
        <property type="protein sequence ID" value="VDO78634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW59"/>
    <dbReference type="STRING" id="387005.A0A183HW59"/>
    <dbReference type="WBParaSite" id="OFLC_0001172101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001172101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001172101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001172101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8000" checksum="E0EAC49DE29B0431" modified="2016-09-07" version="1">MGDTVKGWDRCCHIKEIMTKEEEQRGDGDGTQYQLHYRGLTINADRWVEESSKCQYLPEDEMILLCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWH4</accession>
    <name>A0A183HWH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11846</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017643">
        <property type="protein sequence ID" value="VDO79686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWH4"/>
    <dbReference type="STRING" id="387005.A0A183HWH4"/>
    <dbReference type="WBParaSite" id="OFLC_0001183601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001183601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001183601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001183601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11037" checksum="37AE341D5106CD9F" modified="2016-09-07" version="1">MLGTDGNFNKFIFFRCLRNWLEQDNSCPTCRLALPSLSNSTVAEGSRQRQRASNFSRVFRFSGTLHTRWLPSFSVQLSHNVTHNFFQHDRLSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX02</accession>
    <name>A0A183HX02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018083">
        <property type="protein sequence ID" value="VDO81135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX02"/>
    <dbReference type="WBParaSite" id="OFLC_0001201401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001201401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001201401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001201401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="5095" checksum="D28D891D500CE179" modified="2016-09-07" version="1">MKKKNDAPRMMLLFLKNVLKILNGLNTKIQIRKLLLKNLEFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXB7</accession>
    <name>A0A183HXB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12131</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018435">
        <property type="protein sequence ID" value="VDO82153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXB7"/>
    <dbReference type="STRING" id="387005.A0A183HXB7"/>
    <dbReference type="WBParaSite" id="OFLC_0001212901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001212901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001212901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO82153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001212901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14998" checksum="DF5642B41AD2E0FA" modified="2016-09-07" version="1">METTDVSVIRNDASAPAIINLSATPDMIKEVPTLEPACYIIDTKHLVERLWLVTILGSTVSTISIVENAFLFLLFITSKQHRRSYSLYLLLLALTDIFISLTYILIMSVKVLYEYNEWIFMKKIWYVFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXN1</accession>
    <name>A0A183HXN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12242</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018763">
        <property type="protein sequence ID" value="VDO83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXN1"/>
    <dbReference type="STRING" id="387005.A0A183HXN1"/>
    <dbReference type="WBParaSite" id="OFLC_0001224401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001224401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001224401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001224401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6965" checksum="F4B7983B92CD1301" modified="2016-09-07" version="1">VKVTGDHLVVRCTRELKEGRFGETKREINRSYKLPSDIDVRTLKSTLTAKGHLIITAEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYK5</accession>
    <name>A0A183HYK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12567</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039869">
        <property type="protein sequence ID" value="VDP11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYK5"/>
    <dbReference type="STRING" id="387005.A0A183HYK5"/>
    <dbReference type="WBParaSite" id="OFLC_0001256801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001256801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001256801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000208">
        <property type="entry name" value="RNA-binding protein 27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14605">
        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001256801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="67931" checksum="7217B5E2FF951D86" modified="2016-09-07" version="1">MKGDQCIYDHGPDPVVVDDIALEKMVTNGAKSAVTQIATNFSVPPPGYTPLNPPPPGVDNVYATNSGAVVSAALSEGYNPEAPALSASSIPIVAAAHSLDFSVPPPPIPPVVVNHPWRPTTYTVPAMSSSVLIHPAANNYDPTHSSTTVPSHNVTQLTTGQKRRGRGLGIGNAGRYSQNVGAVNRTLQVRKIPAELNNIAKLNEHFGQFGQIVNMQVCFEGDPEAALITYANRYEAVAAYKSTVPILNNRFIKVFWHSTNGQANNITAPTNSSSVTFNARGSLTKTVHIGSRLASAVKNSQTVHSTNSQNIEPQASRSAISQSLIDREKYIEVSSQRPGVVLVADCSGNSNNDIVFVLQVRRRRKQEKENRMRLMDLQRRKSDLMSKEIEQQKIILEKMKEGDIIPEKKKKLYKIFKRLESSVAKTKGEIAELNEKLMKTKTDSEASKTTDNANGCSIAAESVIGMDLSDAGELLVSDMVPSPKKIRLQDSSQTLDNRSKMVVVRGFEAGTENEVIIHMEHFGELIDMDFGVPAQDKLLTAYFTYKKRRDAEQAVSLGADYPVGNLIVEWAPKRGTKASGVIPDEKRQPSERVTPAALLASCPLDEVVMLLSFYIFYRYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYR2</accession>
    <name>A0A183HYR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS12624</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039885">
        <property type="protein sequence ID" value="VDP11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HYR2"/>
    <dbReference type="WBParaSite" id="OFLC_0001262501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001262501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001262501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1830"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="227"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="419"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="524"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="758"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="849"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1197"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1267"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="1311"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1506"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="1604"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1915"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1915"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1925"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1526"/>
            <end position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDP11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001262501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2010" mass="227788" checksum="470EBFE103489FE5" modified="2016-09-07" version="1">MVSYANCIVNVVDINDNKPFFDKVFYSASVAENGDSDELVTKVVARDSDSGMNGEISYSLTADESDAWKYFKINEESGEIFTVSALDAEYSKEYNLHVIAKDHGNPQLSNTVVVKIEILDKNDNAPRFSNLFYGTVAENSPLGTSILRVTSYDADMNSTLFYYLEGDYADSFLIDQQTGWISLAKEVDREKKNEYSIKVKAWDGLWEVRTSLTITVEDINDNPPTFNDSSYKFLVAANSKIFTEIGQILAFDVDEGLNGQVRYELRCDSDLFMVEPTNGHIFSITSLKEYVNNTMECKGLASDQGFPSLNSNVTIYIHITDATENNETKQHYYEFALLPDIDPPTVVGQLPFHNTIAVVNDSRFMMDEGGHLITNATFSEAKLGDKIIFSIVTNNTNDPIKAIITIEFTEPNIHRPEFSFKRYKFSVQENCRLHMPVGVVMAKDPDIGLNGRVTYRIINDVELLPFTIDPIKGTVLTTRHLDFEETNSFHFLITATDSGFPIFNDTAKVTVEVLDENDNGPEFENHYVQYTISANLPLNATIAHLSAVDIDSEPNARIVYHLLPDSAAELPFAINATSGVLYVSSELLYETTNEYLFRVLASNTRTANLEYLKLVPESSQNGTYSDILLVEIFVHSDGESEIYFPETERNFEISASALKNTIIGRVEAIYPSGNYDNKILYRMTSNNLIDMNDRTGEIYVKKTWNGTTGTIMVQIVATSQLSRNPNFKPNLCKVYIELKDTEAPPILLSHYKFSLPEDADSTESFVIFEHFPQKKKYRLDIVEEGTGSDTQQPFCIGDPGKLRLCDPVNYKQRDDYRLQIALIQDNVIRSRAQVTIIVNNVNDKGMSLNPAASIGYVIENSPIYTRIMKLHVVDNDISGKQTSFKYKIADKDLSQIFAINDNTGVVSSLKVLDREKRSLYVVPVMVSDLDIPSRVATVYLRIYVDDQDDNAPELEPRIINLGYLREIPDVISMHAFPVDADQVGTYSCRLLNDSQTYNMSDNCMLKLSRNLLEADYFLNTPLLVEASNRHTNITFPTNLRMRRDTSPESMLNDFGVIVELWGIEWSIANSISAFEEAFPHLVLQLLGLQQLEIDLFRVFIAILDRHLVPTDRVDALKLLKQFFAEKFVSNVHVKQIALDMCTLTPEQCMYGAKCSQNITKNGELFELIGYRTSFIVPVVISHINCICENDMLCDVDVNRLCDENEKCHNGGTCERSTGTCLCAKGYTGKFCKNDVDECEDKNICGNGKCLNTFGSFVCACDDNEAKILAHCNNSNNNICDNCQRGKCVKQNNGQHLCECDEGYSGRYCHLKIRCFDGFSSSLQFPFHQQIFKLTQGFRTLNPFGLLLGSFATAAFKGPHFTLALRNGQIHLSANSNEKKNELFVEEKVNDGNWKMIRFRYKHRTVKLTIEHCDEDGFCEPCQSIRCIAVANNFDIPTSTGEQFAYIGGMNNSISSSVITKQIGTENFEGCMRQIVINEHDIDKGFGFLEQNIVDKDNWKTCADGSDFDVCSGGICVVDENDKKCICTDGFDALNCHKGWLLNNNTVNSQGRFLQDFAFILLVKLKVTKFLAIEPWHVKNGGIIFQLSMYMMQKLELAKNNISMKMSSRKYRRSIIDDEEKQLREIPCEESEIEGDILNDIPAQWMELDFKTALSNTVIFAIVEENGFSKIEVKRFGKIIVGYLRFWQLINGSAYMIAKMKDTHPIEVYIASNLDDIDWHRLSIQISEDQKLFRIEIDGHGKEIRSEEQLPTLISSSLLSLSLGHNTVNYATAFSGCFRRFIVNNQAQNLDVLEGNQLSQQIFKNVGQKGARKGCDQFLMKRAVISLEWKMLIFIGLIFILFFISIFAVILWLVRKHQSPDSIVKERRKCWKPKLSKLLSLMRSSSKTRHIDDSNDVTIQRAVYCGPNILQNNESEVKNLSSQDKSNTTESTESGSSNVKQLNAALRESHVFVFNPQRQSFSECNMQERNRHRRQCSCKIQTTKKSDQEKYCQSLSNSTISEKFFEHRRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I004</accession>
    <name>A0A183I004_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13066</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040030">
        <property type="protein sequence ID" value="VDP12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I004"/>
    <dbReference type="WBParaSite" id="OFLC_0001306701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001306701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001306701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552700" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001306701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8399" checksum="3C9442E44B4D33B9" modified="2016-09-07" version="1">MTVISLIITIVVVIVHHYHPLSPLSSPSPLLSTLITPDHPCSACYFGSESYSCDGDVTNVNKLVESLQDTNANKGSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0H9</accession>
    <name>A0A183I0H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 106A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13241</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040105">
        <property type="protein sequence ID" value="VDP13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0H9"/>
    <dbReference type="STRING" id="387005.A0A183I0H9"/>
    <dbReference type="WBParaSite" id="OFLC_0001324201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001324201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001324201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001324201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24662" checksum="BF1E3972F1811146" modified="2016-09-07" version="1">MNSVIEGTRNLMHKMRHRFISGNSTGDHYSSFDSTVNLANECATPSRANSMGYTELMEGSVPCPSCKGSGRIPKELEETLVALIPVNDDRLKPKRTWLYVFGVVLGCISLAGVVIFLLVPRAIYLSSIRPPVEIITVFDHDKNHITVLEIISYFQKSSALTDHFYSEYCQAPFSLLISLYVNMQFDISVTLEYLSHREQATLSVVQQVCCVPSGNCTAAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0I3</accession>
    <name>A0A183I0I3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS13245</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040107">
        <property type="protein sequence ID" value="VDP13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0I3"/>
    <dbReference type="STRING" id="387005.A0A183I0I3"/>
    <dbReference type="WBParaSite" id="OFLC_0001324601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001324601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001324601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552726" evidence="8">
        <location>
            <begin position="17"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="508"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001324601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="629" mass="72080" checksum="53235AEE97A746B2" modified="2016-09-07" version="1">MLFILVAAAFWTSIQATLTEFSGFHCMMRHSMRMNRVVHGNPQETPPPFEFRFMDDKGYETRYYEPGKIYTIRLTGSVHFRGLLLQGRLTNENGFLLGSLKGGRFIENENWKTFGIRMQDCNPRGSSWEDSVTHIDDSQKFIVQLEWTTDKDIGAVQFMLTIAEEDEIYWERWRPESGFIIPISWKGKHLNLITDERMAMKRAAKKRKSDESLTSSHYMRSVSSAKNTENFTATNRKTETDQVLSNRKDRTVPETLRDSAYHHENEVEEVDEKGWSTIVPFTTPFWESENSTTTELPLIRTTAPWQLQIGKMNEIEHIYEGRFPKISTEDLNNELTETEVKMTSMTRIDKCIENICQNGGRCRLDSTAAVGFICLCKEGWIGPLCESSNFFIFSSHLIAKSIHNCVSGKCVNLKDSYECSCSKDYAGKFCTRKCDPNLCKRNGTCVEKSNGELGCKCPPGASGKHCEREINECNFRRCKNGAKCVDKWNDYLCICQPGWMGKDCDRPCQDIYRSCKQWKKQGQCEQMRDHTRFFDVNCALSCGQCTYSTETVRTIKPLAPVLLPLAWMIGIWKAEVNGTRSRTVDYVANFEGMSYTEILAITVADVLMFGKPSINFTYVDATIIIHIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1D5</accession>
    <name>A0A183I1D5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13547</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040259">
        <property type="protein sequence ID" value="VDP14041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1D5"/>
    <dbReference type="STRING" id="387005.A0A183I1D5"/>
    <dbReference type="WBParaSite" id="OFLC_0001354801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001354801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001354801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="147"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001354801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40243" checksum="B389C25A7D002183" modified="2016-09-07" version="1">MLTTDKCFSLLLKSLGPTANPEKKVPRGAIGNNSPNNQKSPRASNVRVALNVKKSEILETVTEGELVESSLGIGYICVNLINQSVLQELTKNHEFIILHISMNINKDYFNIDKLIESSIAPSIEISMNPENYNLLEAVLAQESNRNSDFVFTRGSGAKNDATSYHVHQNILKQRSFMLEGILRQKHSLPTDQLLVVDTEDRIIFPYLTDDDMKLLLTYLYTGEIILPKFDGFARVGRILSLLIDREQLLNIFMHWQKLIVKNLLQVEKKNDNDRIIEESFKALISVFSAPYGALPYAKRMALSLLADQITKSNEALIEKYNEQSRYGPYQVGHFIEIALKLKRIITSIKKMPCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1I5</accession>
    <name>A0A183I1I5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS13597</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040284">
        <property type="protein sequence ID" value="VDP14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1I5"/>
    <dbReference type="STRING" id="387005.A0A183I1I5"/>
    <dbReference type="WBParaSite" id="OFLC_0001359801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001359801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001359801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000002">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="294"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001359801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="531" mass="62699" checksum="680E4120B0C51842" modified="2016-09-07" version="1">MRIKKKYESGAATNYITRGRALKKLQLSLKDFRRLCILKGIYPHEPLHKKKVNKGSTENRVYYYAKDINFLASEPIINKFREYKIFLRKLTTAKAKRDEERIKKLYERRPEYQLDHIVKERYPTFESALRDLDDALCLLFAFAVLPHTKVITSSLPIPKNVENLFLFQVFVSIKGIYYEAEVMGERVTWIVGHDRGVGHVSEVDFSVMATFAEFYVTMLEFVNFRLYQSIGLFYPPKLAFKSDKSENNDETEEGRIYSMAYPLSRFECHEEEIDININDAVNNELNEKLCDVEKRKKLFVNCRFWLNREVPKDPLAIIIRSCGGLVSWENCPAAQYYENDVQITHQIVDRPLLDNQRNLNRIYIQPQWIFDSFNRRSRLPVNKYLPGAILPPHLSPFSSDYDLYEEQLKQLKQLKFLNKGSFLELLGRVPKNTSSSATEKKEIETESRLQEKEKILKEKEVSTMNVNKGRMHKENLQKKLNEKGHELKLREMLIPKKRKRVYSKIKRGIKRRIHEEKKLNEKRLKILEAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2M2</accession>
    <name>A0A183I2M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAK_assoc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040515">
        <property type="protein sequence ID" value="VDP15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2M2"/>
    <dbReference type="STRING" id="387005.A0A183I2M2"/>
    <dbReference type="WBParaSite" id="OFLC_0001398501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001398501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001398501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001398501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22012" checksum="D8F8A1DA6A2C57E2" modified="2016-09-07" version="1">LNFYVCKKKRNQINPFSCWILFSFDNIFKVKCTRLRSLPQCSGIAEGCSGQTWLAGFNLYVIENSTKVTLWDPVCCTSQNIIIDENACINDRLNQPNKNFEHEIANDLAYRGMQCWHQYNANNTLFDLIWKMEICPFSSSVEKLHGLKDCPECECDCGKSQCPDTNYPSKLVHKHPENRSCQCRCDCITLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2V8</accession>
    <name>A0A183I2V8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01040575">
        <property type="protein sequence ID" value="VDP15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2V8"/>
    <dbReference type="STRING" id="387005.A0A183I2V8"/>
    <dbReference type="WBParaSite" id="OFLC_0001407801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001407801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001407801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001407801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20181" checksum="988D673F92DAC717" modified="2016-09-07" version="1">GFRNSAVNSVKQELIFAGSEHGKIIGLKALFQSNFEPPALIFVQISWQSKLRARQLVSIIESLQPPIPVKMISSEKTETERESAIAEFRSGEVWVLVCTDLMGRGLDLSGVHLVINFDLPTSIISYIHRIGRTGRAGRQGHAVTYFTENDLNFIRPIATIIKQAGFEVPEYTLRMRKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Y9</accession>
    <name>A0A183I2Y9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14101</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required during maturation of the 40S ribosomal subunit in the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040598">
        <property type="protein sequence ID" value="VDP15493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Y9"/>
    <dbReference type="STRING" id="387005.A0A183I2Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0001410901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001410901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001410901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="8">
        <location>
            <begin position="69"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP15493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001410901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="763" mass="87188" checksum="94157161A9306283" modified="2016-09-07" version="1">MGAGHRAGPLKQSNKRHKSGRHRSKGALDAVAGGIFFSFSNKKNKISEYYFLSVCYYVFSGKVGCKAVTGKHRFLVGKKARRLQAKQIRDNKRAVLSESYIFSNNYLQQPPIFVVQRLKSRYVFGAPNCANTDVVLDYVKVSDVIAFIWPANAEITTEDDILISTLLAHGLSVTVHFVPGLSTMATTKQKEIARKNVTKLISNWSFEDEKLMHCDNENDGLLALRSISTMKKKQSCMQRMRPHLIAENVEKSEAEGNLCTLKVSGYLKGPSLNVNSLIHVLRLGDFQIKQIVIENDPYVPDKKVRVDTKVSETIFEPDINLQTSLLSEMIADPMDAEQTWPAEEEIMKEALKTKKIVKNVPVGTSAYQAEWIINDEDEISDEETEDDLEYDNAMEEAVNGGESDCENEMEIEKMSVNSDTESSTEIKDEEINMAEVEKYRKARENEQFPDEIDTPMDVPARIRFQRYRALKSFRTSPWDPLENLPKTYSRIFKFSNYRHSKKIALSNIEAKTEYSPPRGAFVSIYISKVPISFIDIWPRSTPLIIYGLLAHEQKMSLVNMVLKRHPSCTVPIPNKQRLLFHVGYRHFEAEPVFSQHINGDKFKMERFMPNDGTFVASVFAPLMFPPVTVLVYRLDNRGNQQLVATGGVLDINPDRIILKRIVLSGHPFKINRRSVVVRYMFFNRDDIEWFKPVELRTPSGRRGHIKEALGTHGHMKCMFDQQLNAMDTVMMNLYKRVFPKWTYKPVMLYPSSGSPNESGLMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3S6</accession>
    <name>A0A183I3S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14388</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040815">
        <property type="protein sequence ID" value="VDP16831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3S6"/>
    <dbReference type="STRING" id="387005.A0A183I3S6"/>
    <dbReference type="WBParaSite" id="OFLC_0001439601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001439601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001439601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP16831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001439601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42111" checksum="31C41AA11B713469" modified="2016-09-07" version="1">MEIVDSDMEGSKMEIDDSDMEISETMVSDQKNTVKTDRKTNTSNIITSATTTTIAISGNNEDDDDDDDEPSCSWNADQKMKQLLLEDYLKTLQATDSILEPNIEETIKGFLRNGGHPEVIITSLADNFRGLAKYCELLGDWLADLEGDRKIVHKCFEKTLSSLIEKRFVAAVVDRNFEAADDVDKWLPELLEHSIWRNLIYTLIEQNPRSKFLMKAIRIISDAGFQYEITNVRPAAQQIEICSRMVLTAIDSFFLKRKKGPLTEDYEKTLAELIRVVCYSEHTYLFTQVLLHQIIKEEKNEEAAACTHLAQLLRREAHKRNYQDTYDIHIALDGGSDDCSSNVKRTIYTMLSKKCLNQADIIRLYEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4E4</accession>
    <name>A0A183I4E4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF_CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14609</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040998">
        <property type="protein sequence ID" value="VDP17848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4E4"/>
    <dbReference type="STRING" id="387005.A0A183I4E4"/>
    <dbReference type="WBParaSite" id="OFLC_0001461401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001461401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001461401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like calcium-binding" evidence="2">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP17848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001461401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21666" checksum="C1AB3547CF5BCBF1" modified="2016-09-07" version="1">MDRMLNSTPQPDHYSEPIKECQCICANNGEALMKPMCGTSIEPFRPVATLPSAVDGECPCSIPSKDGQCPSGYFFNHGKCYDVNECQQQNGGCSHGCVNIPGDFYCACPHGMMRDPTDPKMCINVADSFDRIAAMLGQYLYANRYNASSVGVAKNAPTNDKIVRYKATVKSKDDKTISLEWSLMPDVVRRALKWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4K8</accession>
    <name>A0A183I4K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041065">
        <property type="protein sequence ID" value="VDP18153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4K8"/>
    <dbReference type="STRING" id="387005.A0A183I4K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001468101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001468101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001468101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001468101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14034" checksum="9919BB9B23E6E252" modified="2016-09-07" version="1">MLCGAGKVEKKFKRLESETVVQLKGLNLGRRLPLGILAVGKPALRECNCLSFAEDVITELYAVFVALSGLGPGHRIQSFDEAKRLDKINERMPPSMVTPTQSPMASPSARRASPNVGNSTTTIPPATTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4M0</accession>
    <name>A0A183I4M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041081">
        <property type="protein sequence ID" value="VDP18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4M0"/>
    <dbReference type="STRING" id="387005.A0A183I4M0"/>
    <dbReference type="WBParaSite" id="OFLC_0001469301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001469301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001469301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001469301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27404" checksum="AF381E1C75A98AFC" modified="2016-09-07" version="1">MNKVKKAQPGTALHIKKDPLPVQGCVTLLTFSRRLKKDLVAVVEGSSLHFCSLDDHCTENICEILTYAIVRNIPKAYHAKNLRNFFSNFVENGRFYCFHYRHRPELHVDSSVNEPTTSKEYERFCCVVSFKNDEERAACIRYYHMKFWIDDKGLQMPLKCFIFPLKASEISDDSCQMSTDLDFRFFIELKPPSLMPFGNVGTPTKFFLEQIRLCKLPPTVLTKLGIETKRRVGKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I589</accession>
    <name>A0A183I589_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14901</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041336">
        <property type="protein sequence ID" value="VDP19493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I589"/>
    <dbReference type="STRING" id="387005.A0A183I589"/>
    <dbReference type="WBParaSite" id="OFLC_0001491201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001491201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001491201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016060">
        <property type="term" value="P:negative regulation of phospholipase C-activating phototransduction signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000002">
        <property type="entry name" value="Arrestin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP19493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001491201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27124" checksum="A08DD1E83B43BFEF" modified="2016-09-07" version="1">MDERRAGTRVFKKTSPNGKITTYLGKRDFIDHGDFVDLIDGMVLIDEDYIKENRKITAYLLAAFRYGREDLDVLGLTFRKDLISQTFQVYPVDTLHLRPLTRLQERLKKKLGNNAYPFWFEIPTHSASSVTLQPAQGDTGKPCGVDFELKTVVESPDGNGVDKPKKHSGLLHLEASLDKEMYYHGESIAVNVHIQNNSNKTVKKIKTCIAQIADICLFTTASYTCEVAKIESTLVFHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5K8</accession>
    <name>A0A183I5K8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS15020</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01041494">
        <property type="protein sequence ID" value="VDP20040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5K8"/>
    <dbReference type="STRING" id="387005.A0A183I5K8"/>
    <dbReference type="WBParaSite" id="OFLC_0001503101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001503101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001503101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP20040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001503101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24650" checksum="30CE5F014AA29C3C" modified="2016-09-07" version="1">MKSLLPKTLANHPSTSRACTVESLNDNVPDRPEIFSQPKRKSHSIADIFAGIDTDNNDVRFRHDDMKPQKSIVVESNYDYTPKRKDELKLKRGATIKVIRRDGEEGWWYGEKLDGSGKKGFFPQNHVQLAKGLAKEIDPNAVQFTGLLGAGGFSVVKSAIYKGREVAVKIPHSKFSKKEILEAVREEASIFQMLDHRNIVEMYGVIVGDEPALVLELCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I676</accession>
    <name>A0A183I676_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CDGSH iron-sulfur domain-containing protein 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15238</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041813">
        <property type="protein sequence ID" value="VDP20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I676"/>
    <dbReference type="STRING" id="387005.A0A183I676"/>
    <dbReference type="WBParaSite" id="OFLC_0001524901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001524901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001524901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001524901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17924" checksum="47D7F7E23B3BC6D2" modified="2016-09-07" version="1">MYILIHFKKSLLCYTQVSKILSRARSGVKILNPSAVLYPEIGTCLDNKPIRLKLHKGEQYSWCSCGLSGNQPWCDGSHSAEGVTTLKPVHFEVERDGEYNICVCKATKNRPLCDGQHVKVKKRQYTDPPQYCAYAESPVYDGVANKLGYKPKQGRWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6H6</accession>
    <name>A0A183I6H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15338</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041980">
        <property type="protein sequence ID" value="VDP21414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6H6"/>
    <dbReference type="STRING" id="387005.A0A183I6H6"/>
    <dbReference type="WBParaSite" id="OFLC_0001534901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001534901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001534901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001534901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12310" checksum="151F8C3D4008AFB8" modified="2016-09-07" version="1">MTSNSSTDPVLDASESELKCDEGGYDTDEDIAREMAALDLPSCFGESSRQERSCRSCERKYKSYHIREKSPHHECLSDYLFCNGPYLERKSWFHDYRKRYSYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7B5</accession>
    <name>A0A183I7B5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15627</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042490">
        <property type="protein sequence ID" value="VDP22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7B5"/>
    <dbReference type="WBParaSite" id="OFLC_0001564001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001564001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001564001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001564001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8381" checksum="98C9D29FED3E2780" modified="2016-09-07" version="1">MTRSIHERKSDRIGSDLKSEQLSSLPEVKGPLGVQEEGNRKERTKKRVRGVIFKYDKWYLNYFLISLSMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7B8</accession>
    <name>A0A183I7B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 11 open reading frame 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042501">
        <property type="protein sequence ID" value="VDP22949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7B8"/>
    <dbReference type="STRING" id="387005.A0A183I7B8"/>
    <dbReference type="WBParaSite" id="OFLC_0001564301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001564301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001564301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001564301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13705" checksum="806B34F28D11478A" modified="2016-09-07" version="1">LVRVSKHLGQESYQYKRSSFIKKSYYRENSEKYDKKYEEQERDIPKSIDFENVSMCSCSCYQLPYSEADLRQRYSVRNHHLVHSDNQLSTQSAIFEQQSPSTSTDNRPIFKTTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7H9</accession>
    <name>A0A183I7H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15691</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042632">
        <property type="protein sequence ID" value="VDP23251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7H9"/>
    <dbReference type="STRING" id="387005.A0A183I7H9"/>
    <dbReference type="WBParaSite" id="OFLC_0001570401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001570401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001570401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF5">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP23251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001570401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15112" checksum="C5E27EB45E860BB8" modified="2016-09-07" version="1">GTITAYYQTYFPSSVFVVEELPVFALIGVFSGLLGALFVFIHRRIALFREKNRLYLRIFGKNPLFFTLLMAAIFTFRETLADFIANCTFILSNITSQGCSKERLERWTGINHEFNALNSLAIYFCVYVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7R1</accession>
    <name>A0A183I7R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like_bact domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15773</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042843">
        <property type="protein sequence ID" value="VDP23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I7R1"/>
    <dbReference type="WBParaSite" id="OFLC_0001578601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001578601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001578601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001578601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12021" checksum="728C75B4273B9991" modified="2016-09-07" version="1">DVSDVLLLAVIPFSLGIETLEDNQAAVIIKVHQGEKKSAVNTKLIDQFSLEGVSPTPHGVPQIKVTFDKETNGXXXLEGVSPTPHGVPQIKVTFDKETNEIVHVSAKPFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I835</accession>
    <name>A0A183I835_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF3523 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS15897</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043172">
        <property type="protein sequence ID" value="VDP24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I835"/>
    <dbReference type="STRING" id="387005.A0A183I835"/>
    <dbReference type="WBParaSite" id="OFLC_0001591001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001591001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001591001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase family AAA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001591001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21877" checksum="A7CF06114E8E8405" modified="2016-09-07" version="1">QKGYSFDSSALERAADAARQLERSRNAKEAFEIARLQEYTKQKEYEAAAKQAELQMQSLRTEQIRVAEEERRKTLTEETRHARARAEHQDQLARKRQEEELATKARMQAESLKKQEESVRKQEAMRKATVEHELALKHKYDLEKVQAETHARAKAARENRDVNLEQLRATEEERRKTTIEKIKSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I842</accession>
    <name>A0A183I842_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF4217 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15904</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043215">
        <property type="protein sequence ID" value="VDP24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I842"/>
    <dbReference type="STRING" id="387005.A0A183I842"/>
    <dbReference type="WBParaSite" id="OFLC_0001591701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001591701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001591701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent rRNA helicase SPB4-like C-terminal extension" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001591701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20226" checksum="767711741D6DEBD2" modified="2016-09-07" version="1">MRQQIVKMASKEREILESGTRAFMSFVESYVRHDCNVVCSYKDLDIIGYGHAYGLLRLPRMKEFHHSDLSDFKRSDLNTSEIPYKNPEKEKRRQEKLLLPKNEDKSMKKAARTPKKGLNAKQAPKNSARKRRHSENKENTDDLRSDFALLKKLKKGRLKKKEYDELMTDSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UKP9</accession>
    <name>A0A3P7UKP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000003">
        <property type="protein sequence ID" value="VDO24184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="80" mass="9232" checksum="741C63C33CC37438" modified="2026-01-28" version="1">MPPKSNGLERTYWISCSWGLKRYLSSVSYSWGHDLNICTPPQHETHTPREYECNYYHKHLMNGSERIVGKICIFGEGSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7USB7</accession>
    <name>A0A3P7USB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000186">
        <property type="protein sequence ID" value="VDO26124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="71" mass="7647" checksum="23836011E4D758DE" modified="2026-01-28" version="1">MIIAVITRMVTIDTAEATSGTLIVTSDLSLLFFYAMTGARSTGVNHTWFPSLLALPVDSPPLHFLTANISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UUQ6</accession>
    <name>A0A3P7UUQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002999">
        <property type="protein sequence ID" value="VDO38920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H9E8"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF4">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="531" mass="58052" checksum="47E9A5CB2FB8E5E1" modified="2026-01-28" version="1">MDTIHFLLILAIRVMPLTAAQLDVFALPQAPRYAAKPTVPPEYKKYFELEDHARGLVESVIGPRPGGFFPPKSYEIGRPTRFNIDNSNATLNEVERSLDQFLNAPSGFPQQLPPGFGQGFSLANSGSPIASFTNIRKHPGMQSKAMAEEEIEGSGDNVHSSIRGIPNVYPDLARPPIELIRPHLRQVAVEKMPTIPKIQSQPEVPDGGFGPNENVFRRTSNKESGDEGVENEEYGGLTDDSPSSGGLIGTIINLIGLNSKKNKLEQPDTRSLTKAFGNLIGSENSPIPAKNVIADVLYKALTGGSVMANGSDENPDSKLTSLTLTPAQQAVIGENLEMIQNLITQPSSPLCNPKPIPIEEFDVDAFMGQWYQVMYSPPLATGPCSMVAYKKLADVNNGGVGTIFEVFEYTTDGTPYVKPRISSGYAIVKQAGELIYRTTSYQDDVNVHIIHAGPLNEAGQYSFTILSTNCNYPLYVFARDPVVYKQRYETTVNQILEQKGLINGFSRLLNIVAPVDNSVCTFPPSLFNIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V1B6</accession>
    <name>A0A3P7V1B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000571">
        <property type="protein sequence ID" value="VDO28914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1A9"/>
    <dbReference type="OrthoDB" id="5829006at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="161" mass="17868" checksum="C6421B0EDFC02808" modified="2026-01-28" version="1">MFPRLILLSLITVIGFGTICRAEDECGTPETDYSPCVMKNRADALFRQCCQLYVPESCHDLCQYEIEEIPARNLLIKAIASRKCGLKHISAVLYCASQNQDNRKCCEYLNLADSKLGVGDRCLRFCDPAGQGINAISKGDATCLFNLNVILYCHHSGIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VD83</accession>
    <name>A0A3P7VD83_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001404">
        <property type="protein sequence ID" value="VDO32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VD83"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="88"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="339" mass="37804" checksum="F59CD6E9B050491E" modified="2019-02-13" version="1">MAGISINLSTILISFVLDTFIYALLAWYINIVFPGTYGVPQPFYFFITPRYWRGDKYVKQSISDANFTTPINPSDNYEQEPTDLKLAVDISNLFKIYGNGTKALDGLNMRFYESQITALLGHNGAGKTTAISILTGLLQATSGAVFVYGLNFQKYMRTIRSFIGICPQYNILFDKLTVTEQLKFYGTLKGIPENQLNDEVYETMENLGLIASKDKLVSYLSGKLRSGMKRKLCIGIALIGGSKLVILDEPTAGVDARARRSIWDILIKNKEGLKNKEPFLGRTVILSTHRMDEADILADRIAIISKGQLQVAGSPLFLKKKFGNGLYLNILKTSSIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XLP2</accession>
    <name>A0A3P7XLP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016154">
        <property type="protein sequence ID" value="VDO75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XLP2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="60" mass="6484" checksum="9D722BA89A76C870" modified="2019-02-13" version="1">MPSLFTTYTAVSPSFSTISGENVASDRLFRDLSGDFTVDTVIFTCGVSSRKVGVTSTYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YMH1</accession>
    <name>A0A3P7YMH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004347">
        <property type="protein sequence ID" value="VDO42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846317at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="66" mass="7282" checksum="7B3A75B86E24AC58" modified="2026-01-28" version="1">MAGETVKGAKTKIMRAAETLLGGYFNVICAYGDFSYVTTTSLYCLESLDDINCYAFLTGNNRPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C1K3</accession>
    <name>A0A3P8C1K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039948">
        <property type="protein sequence ID" value="VDP12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZC0"/>
    <dbReference type="OrthoDB" id="734at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="105" mass="11971" checksum="2E15083FBC53C15E" modified="2026-01-28" version="1">MAVRAFLNKLTSEDLFVWDFRKQKSFVMFTMKARLRRFAIHVEGVYPNLNFRSDKIVSKAIKCNSGKPCKKTARIVGVVTGKFHPHGDMAIYDSLIGMALDFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXR3</accession>
    <name>A0A183GXR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS23</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000006">
        <property type="protein sequence ID" value="VDO24249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXR3"/>
    <dbReference type="STRING" id="387005.A0A183GXR3"/>
    <dbReference type="WBParaSite" id="OFLC_0000002201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000002201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000002201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12430">
        <property type="entry name" value="RRM_LARP4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
        <property type="entry name" value="LA-RELATED PROTEIN LARP4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO24249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000002201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46936" checksum="29630E323655316A" modified="2016-09-07" version="1">MDDGGDDGDLDQMIQLLLHRSLSPVLLTVSSLSELSVASKVVQLLLSEEQRHQQQLYYYLNSCILSRLYGKVTLVDLVHGRSENIMKYTYSQENDLVVKLLQNRGRRRKRRISKFLLEQYLKNITVLIKCFGYFLDFVKAVNSNSIDRMLDDMMMPSGECDTPPIPMLPWWFTAECENQLLAASDPPLIQMPMSISATLSTPPPPPPPPPPPPPPPPPSPPPPPPPSSSPAVVVPSAQQIISTANISQSPEQIKQQLKAQLEYYFSRENLMTDRFLRCQMDNDQYVPIRIIANFPKIKRLTNDYNLVVKVLRESSQVQVDEKGQRVRAVSKRCTIILREIPESTDEKEVASMFAGGPPYLSLQYGLNNSWYVTFESEEATERAFLHLQNLGKTFNNKPICVSISKSIILMTYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY09</accession>
    <name>A0A183GY09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS119</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000028">
        <property type="protein sequence ID" value="VDO24610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY09"/>
    <dbReference type="STRING" id="387005.A0A183GY09"/>
    <dbReference type="WBParaSite" id="OFLC_0000011801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000011801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000011801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000011801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64955" checksum="E9F7159763E48EB1" modified="2016-09-07" version="1">MADWVIYGTELEEVSDGTNSISNTQPLRIEEQVVKDEKGRKRFHGAFTGGFSAGYFNTVGSKEGWVPKKFRSSRDERGEKTDYKPEDFMDEEDLSEFGIAARRIKISANVGGDNSDKQLLAWERNAQSSFESSLAVHLQKIIKPTRNSIGIQLLKKMGWREGHGIGSKMSRKALEKQKLNDDRIYGKRGFYNEGAVREADEMAPNFLFAPSDFDPTMLKSSEGVHGLGYCGIRQTSVFSEKYGILESTLKLEKKGKGISGQAFGVGAFENDDANIYTNYDLSQYDFAIDSSGTAPDASCNTNDTSFVMASKRQLARNFFEPPRIPSNFLPLHVPIHPDISQMPLNIKQFSEKMNHLQRAKFLGETDLKPVLELIRDEDRKRLNISHSEDVIQNTFEENPMKQARFKQYVNYLKRGLNYPQPSDMTRLEWDQELQDFQNVLPPELQSLISEVERQQKPLACPDIAAPIADVLKSKFISSSSSNSGKMKETESNERFAATKMKMFGIKTRLIHEWHPAKQLAKRFNVPDPYPSSSLLGVPHLQVFFLATFKNLHEHSFFFVFNSMFFFFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZH1</accession>
    <name>A0A183GZH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS631</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KCTD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000223">
        <property type="protein sequence ID" value="VDO26476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZH1"/>
    <dbReference type="STRING" id="387005.A0A183GZH1"/>
    <dbReference type="WBParaSite" id="OFLC_0000063001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000063001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000063001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18363">
        <property type="entry name" value="BTB_POZ_KCTD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000063001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="662" mass="73182" checksum="7E16FC8570471389" modified="2016-09-07" version="1">MVEQIINLNVGGRRFATSRQTLTWIPDTFFTSLLSGRIPTVRDETDAIFIDRDPEIFRIILNYLRTKQIDLSGVSLINLKHEAQYYALGPLVKRLTLCEELDECACGDVLFNAYLPPPALPLNEDYSFSTPCSTKNNQNSTNTSPGSREFIPVSFPSLHSCNLNEHTAVPAVEMVSNNSALRASQQPRLLPSMEAKFQVPHDVEAVVGKAIKDNSNLSTKLPLSAESNASFASEVSAEKSEAASLSVENGSSMIRNASQHFASHVPTVSLDFILKEELSLLRYSARMSDQLSEPLRVRVIRAHYNAVAVGYANFVCCYRMKESLGWQQLYMSPHMDAVVRHVALYAKFGEKMLAVSLANNSIHLWNISEGDADFGTKIGTFTLLVAVDKLFFIGSQLVALSKIGKVGIWHSMTHNWQVQAGSFLLLGCTNGSIYYIDMQKFPLRMKDNDLLITELYRDPNADIITAISVYLTPKTNLRGNWIEIAYGTSSGSVRVIVQHPETVGHGPQLFQTYTVHTSPVTRVALTTNHLISVCSEYNHVRSWGVTRFRGMISTQPGSTSLASFKVLTLDSTDDILGTDGNDPGPFGDQDGEQVFVQRVVPGSNQVFVRLASNGDRLCTIRTVGDSAITAFLVHECEGSRVNSRPRRFLFTGTSNGSIQVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H116</accession>
    <name>A0A183H116_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000516">
        <property type="protein sequence ID" value="VDO28528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H116"/>
    <dbReference type="WBParaSite" id="OFLC_0000117501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000117501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000117501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000117501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40083" checksum="65F751013982BEA8" modified="2016-09-07" version="1">ISFSQVPGTGNNDVCFTHGQQKFVNPIAGEKYPLELETLLRMGYYNSTAAEYPLGYHCTMKFNSWIEDVSKEDSCLFGLNRTDFKYFCCCYGSEFRGCQELSANLLRKDIYLKDQLFCAMEELVIEKNKFKEENKLTTFVVPIETMIKVINESSRNMACHMRLINNDTINFEGDENLCIQSAALDIRLRPIITTPDIQFKIATASNNHRKCFYYEKYQRLFNQYYVRTRNDDVCLLHYIDSVTLSDMIETSNTDGSVYHSCPGNGFHPIDFSYIFLENNTCTYVEVEISRNFIQKSGDCFNRLFHTDYMPVKLFVCSCSLKKNGNHCDRKLENEIADRAKKFVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1N3</accession>
    <name>A0A183H1N3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1393</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000646">
        <property type="protein sequence ID" value="VDO29367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1N3"/>
    <dbReference type="STRING" id="387005.A0A183H1N3"/>
    <dbReference type="WBParaSite" id="OFLC_0000139201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000139201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000139201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="181"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO29367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000139201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="900" mass="103930" checksum="1B2C5FE290BFCF75" modified="2016-09-07" version="1">MLDSPQLPSVVDLSFNYNGSRTRFNIVEFANVSTVIISDIEKIGQIVHVVFPEAVVTSRLQPTHNIDYDTKILLGPPLGDFDLLLNRSVKVLVEHNKRCNLLFSLGLDHFDIDHVRHISLAENRCCCKAFFQIPFRQFASKNGRVKCIFLPKTSFKKFIKPRERVRLDSELACLAKFEEFYEWQLKEPNRQSFPIFELLDGPPYANGDVHVGHAINKILKDFVVRSQVYNGKRVLFRPGWDCHGLPIELKVTRDNKQKLKLLTFKEISFVEVRKAARKIALQSIASQQNSFKRWAVTTDWTNPYYTMDKNYVAKELRLFGELYRLKLIYRTFMPVYWSPSSFTALAESELDYKEHNSTAVFYRYTIINSGLILSKCEKEERPTKLYALVWTTTPWTLPMNNAIAYKKDAIYAVVELLAEGHYRRPTQHLYILAKDLIGNFEKETKITTRTLSIFIGSELEGLMYRSAMFNDLAQPFIEANYVTTIVGTGLVHISYAHGVNDFKIALKLGEKVRCFVDERGCYTRDLGHHLEGKNVLREGIDAVLQMFRKNVVYTHQYKHQYPYDWRTKEPVIVRSSKQWFIDVSQVGIEAAKKIESEALSIGSPHSDKTEALLSQLKNRISWCISRQRCWGTPIPAFYKTDGSVIIGEDIINAVAESIEKYGTDIWWERKACELFPAKLMNKYGIRAEEKLEKSRDILDVWMDSGIAWASTRQGTEPVDLVLEGLDQFRGWFQSLSLTSFALNNKLPYKCIYVHAFAVDENEQKMSKSVGNVVSPELITDGSLYTEPHGADGLRLWVAQYGCEGDKARIGSSVMEEVKRNYTQLRTSFWFLLGAVSGYKGDICYGERFYIDRYILQELAKFTQRCLKNWNEYRFPLMINEYMQFLQHPLNSPYIVSSICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V0</accession>
    <name>A0A183H1V0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS1460</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000692">
        <property type="protein sequence ID" value="VDO29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V0"/>
    <dbReference type="STRING" id="387005.A0A183H1V0"/>
    <dbReference type="WBParaSite" id="OFLC_0000145901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000145901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000145901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000145901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19208" checksum="4335B61A45F40361" modified="2016-09-07" version="1">MAGYALKRLMAEYKQLTLNPPEGIIAGPINEDNFFEWECLITGPDETCFENGVFPAKIIFPQDYPLSPPKMQFTCDIFHPNIYPDGRVCISILHSPGDDPTGYESSAERWSPVQSVEKILLSVVSMLAEPNDESAANVNAAKMWREDRLQFERIADNLVRKTLCLPPSTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2S2</accession>
    <name>A0A183H2S2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS1782</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000904">
        <property type="protein sequence ID" value="VDO30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2S2"/>
    <dbReference type="STRING" id="387005.A0A183H2S2"/>
    <dbReference type="WBParaSite" id="OFLC_0000178101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000178101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000178101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000178101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23651" checksum="83189B8AD03EA33B" modified="2016-09-07" version="1">METDDSFDFLFKIVLIGDMGVGKTCVVQRFKNGTFIERQGTTIGVDFSMKTLIIEGKRVKLQIWDTGGQERFRTITQSYYRSANGILLCYDLTCRQSFESLHRWLDDVSKFAAPNVCKVLVATKADLENERLVERDEGSELANIHGMCMFIETSSKSNLNVDNAFLELACQLKRQYEAGIHLDSQLDAFKISQGTTAISSKWASCCHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H319</accession>
    <name>A0A183H319_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calponin family repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1879</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000980">
        <property type="protein sequence ID" value="VDO31100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H319"/>
    <dbReference type="STRING" id="387005.A0A183H319"/>
    <dbReference type="WBParaSite" id="OFLC_0000187801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000187801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000187801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF11">
        <property type="entry name" value="PROTEIN UNC-87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO31100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000187801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39703" checksum="02CDD5AEE521D123" modified="2016-09-07" version="1">METRVAGQGQPKRVGRWTLAQLRQTDGIIPSQAGWNKGDSQKLMTNFGTPRNTQTKVKSENLAEIPEEVLMRTHGEVRLQSGTNKFDSQRGMTGFGTGRDVCREGIHVNQAPSDLQPLDEEKIRLSDGIVRLQAGTNKYDSQKGMTGFGTARRETTKMMDSKHPDYDHERPDQSEIPLQAGTNKFASQKGMTGFGTSRRETTKICDSAHPEYDPESSIDSSTIPSQMGSNKYASQKGMTGFGQPRWEVLDPSISWQNRKSQGMVRLQSGTNRFASQQGMTGFGTPRNTTYEAEAGELPYEDMKKSETVIPSQAGWNRGDSQKGMTGFGAPRDVKGKHLKRIWELEYPEEAEASLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H398</accession>
    <name>A0A183H398_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001043">
        <property type="protein sequence ID" value="VDO31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H398"/>
    <dbReference type="STRING" id="387005.A0A183H398"/>
    <dbReference type="WBParaSite" id="OFLC_0000195701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000195701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000195701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000195701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6681" checksum="48675A540E455470" modified="2016-09-07" version="1">MPGPKGERGERGPMGPPGYPGSKGKSGYSAALSKIQILFNYILIHSIQDIDDMEKYAAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3C0</accession>
    <name>A0A183H3C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS1978</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001055">
        <property type="protein sequence ID" value="VDO31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3C0"/>
    <dbReference type="STRING" id="387005.A0A183H3C0"/>
    <dbReference type="WBParaSite" id="OFLC_0000197901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000197901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000197901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000516">
        <property type="entry name" value="Transcription factor Toy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000197901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15477" checksum="38226B1E9C677E7A" modified="2016-09-07" version="1">MTRKGRGREETGDNEDQKPPNDPDEDAAARMRLKRKLQRNRTSFSQEQIEALEKEFERTHYPDVFARERLATKIGLPEARIQVWFSNRRAKWRREEKLRNQKRPPGMDTTMTSANSNVSANSAAGSSGSTQGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3E4</accession>
    <name>A0A183H3E4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS2004</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001073">
        <property type="protein sequence ID" value="VDO31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3E4"/>
    <dbReference type="STRING" id="387005.A0A183H3E4"/>
    <dbReference type="WBParaSite" id="OFLC_0000200301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000200301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000200301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000200301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="927" mass="104217" checksum="8F42380A82FE0AE4" modified="2016-09-07" version="1">MLEFGENCLSNARINCELTIPVLRIHLPSRHYYEVIYNRLVNDLSMWQPSSPIFNSSDRPRDMEVSGDGPFELYSTHSSCSHGSTPTVNALGNEKSHDFCLMANINDGRVLLGTEFEDGVVKKLGQIGAILHKMQIMTVNGFHGNKELSYFYSTSKSASFFHKNLTGDVVPYERCVLKRDFAQHFKEGIQAEPVIDEEICFLEEEDNFAVAVRIDFHFSENFKNMLVGVGIRNTTLHLKPYEIAEEFWINQLISFFDIVDYGIPGYELPQITTELHMHFSSSLLAYEHYFENPSPPISLRVMLGSCDISSRIMQDLEIYKFECIFEQLKLFASFSADAQIAANQNETKKSTKFKPKFIHMLSVGMLQLEVMAAKSFGTADSRSMKCPPFLEVRCKNDLLKLWACSDSLCLVINAVAELLNAQTSKMAEPRAGLQTPIDKAAVLNLKRQVSTEQQMANIEKMVRSAVSQSRHEICEYPTDSPENLSASSKVLSNAVTNLIDVTKESTPRNSSGALGIDEGFCLLDEIPGSGIMTGNGKPWARFLFVDDVVPITYDDYLTKIDSNSNRSVLFTMNKIHTPFIKYSIDDVSLELHLYGGADFSTSKPPSKPYCISSGGKLRRDNSPVGGHYRDYSAHVKFIFEVYDKGAPALSTRLFSIGSIEILDKMMSSKINKLLYPHVWDQTFPRHSQSPMFSVRLYETPQHEGKMKVSLLPLRINADQDTLEFLEDYMNDLSGGVTVLQAENFAASKMPEKPWLEVHLDGNSDNTQYAGDTNSNAIANCMEVTMQNDSFLNEFIGRQLETCNDEQRRNSLLTYDLLNLQIRDDLHLDEGNNNNLMTSERSDSASNLFDESAILGPLTDDITNLMDHINSPFPSSSNAMIQCFSTEKVDNNIPALFPAMCEEARSVKSKLGLTKEEKKDDEKSVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3H5</accession>
    <name>A0A183H3H5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2035</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001095">
        <property type="protein sequence ID" value="VDO31649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3H5"/>
    <dbReference type="WBParaSite" id="OFLC_0000203401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000203401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000203401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000203401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8813" checksum="157C3623852E0517" modified="2016-09-07" version="1">MDGYQLKRRKYHQCVVQHKKRNWLQFLHTRKKRRFSTHLKSRLLNHSYCHHLRNHRYWHRLHNLPLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4D3</accession>
    <name>A0A183H4D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein SPEC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2343</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001325">
        <property type="protein sequence ID" value="VDO32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4D3"/>
    <dbReference type="WBParaSite" id="OFLC_0000234201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000234201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000234201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071683">
        <property type="term" value="C:sensory dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019230">
        <property type="term" value="P:proprioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050954">
        <property type="term" value="P:sensory perception of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF7">
        <property type="entry name" value="PROTEIN SPEC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000234201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26006" checksum="FA149A4EF4EA5CFF" modified="2016-09-07" version="1">MDESRPAQAPKKEIAEVSKKWKKIQTMLPDVIEYGIEQGIIPKRQDKEDEKGFSLTSLIKAAEADQNDKRPGDTRIHLPTNDITLMHSAVPFLPLPIAIFCAILNFIMPGLGTIMSGFFALCLGQTRVNYREGQKLMTILINSLVGISQFFTITFLFVGWFWSMAWGGLLIIYSVQYRDALRQRRQEAIATAALEALTRDSILHRRDVKTLVIEHKEKTETKKEVGGQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4E8</accession>
    <name>A0A183H4E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2357</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001339">
        <property type="protein sequence ID" value="VDO32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4E8"/>
    <dbReference type="WBParaSite" id="OFLC_0000235701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000235701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000235701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000235701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13324" checksum="23B7FC0ADC69D650" modified="2016-09-07" version="1">MFVSSSNNCVHCLDNDPQSLSLRISLFANEEGWSGVGWSGGLFEGIACRSAMGRLVGISNGWKEQEERMGNNLSSQCALLCKCSSSMCISVHHNQFITRCQSHYLLVVYVIASSSHIKYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4S6</accession>
    <name>A0A183H4S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RPW8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2486</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001438">
        <property type="protein sequence ID" value="VDO33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4S6"/>
    <dbReference type="STRING" id="387005.A0A183H4S6"/>
    <dbReference type="WBParaSite" id="OFLC_0000248501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000248501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000248501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000248501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21730" checksum="61572123E30BEB06" modified="2016-09-07" version="1">MNSTSSRHLPKVKTPDKLPQICENAIVDKEHLASICIHLCNQLRTIINLLIDFATDVCDESANAYSLLRELEDEVLPFLINLDIEMAASEKLIRINIDTARISETKVDWLLKFNKCKLVFSLFELEMREMLASLSGTVYEDLERVLSLRCRGCCGITFKQELMICLRQMKSTTDKLQKQIQLEQTVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H560</accession>
    <name>A0A183H560_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001541">
        <property type="protein sequence ID" value="VDO33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H560"/>
    <dbReference type="STRING" id="387005.A0A183H560"/>
    <dbReference type="WBParaSite" id="OFLC_0000261901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000261901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000261901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000261901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8658" checksum="78F9C14716EAF056" modified="2016-09-07" version="1">MWSDRLWKQTSTKMNSSEQEMVKHLDQICGPLTVDLNLHSLSEYLATAVTWLRTEYRAEKERLSPSLSFSQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N1</accession>
    <name>A0A183H5N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2791</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001694">
        <property type="protein sequence ID" value="VDO34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N1"/>
    <dbReference type="STRING" id="387005.A0A183H5N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000279001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002852">
        <property type="entry name" value="Dorsal Intercalation and Elongation defect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190:SF1">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="65690" checksum="08F3E1E6A2EBD620" modified="2016-09-07" version="1">SRQPKKQYTTTGKNYCDVCNKEVCNKYFLRTHMLKMHGIVIDEHKTVIANIDTLEKEKSGTIAFRCDICNTNVGQTRESLKQHKQEIHNVVSLPTSRGHRGSLSSTSSVTSTSTLSQTLKIADQSGNHIDTFVSKIDRGGREENVACAVAVTGVCIVYSGVREEDVPPKMQRYSARFLEDLKIAFERAFALQKNLIGQLRCPLCDGRTIGVIAMQKHLSEKHKMDMNVGALEGFLKDAYEIKTGQSAATLSGSLATDLQQQMTTERDEFTCIHCADIFNDQIQFQLHMIHNHPLVIRSPDETGSAAITTHNMEPLCTQYSLQSSSMADSWTDSEEKPANRSIEDMKEDEDDEHQIASQKFQKLFDCPISWCSRQYRNPIIMSKHVSIVHQWRLKFSLKNGKNKSRGIIAPRKLWKKRYICLFEGCKYRFWSRADCEKHLLCHVGKMISKESVVNGAIENGRNQDINKLIGVREGRIMVNVKNDGNRKEQERNTHTPNSPNLNAMPEGHGQSSGNRKPYTVQTFLVREQASQPSSSENGATTAVGVVFDEMVAHLPVRNTVKEMVRVNVELIPASLQVSPILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5S8</accession>
    <name>A0A183H5S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysacc_synt_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2839</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001738">
        <property type="protein sequence ID" value="VDO34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5S8"/>
    <dbReference type="STRING" id="387005.A0A183H5S8"/>
    <dbReference type="WBParaSite" id="OFLC_0000283801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000283801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000283801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000283801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20093" checksum="4E35B0A6C9DEC16C" modified="2016-09-07" version="1">MDEISYGAAEYTNDPSFEIAWAVEVPFLNLLLCYPLQAAERANIHMSLLLTCNTKELTMHKKFNVIYDKFREIFPKMNVEKITEVELKGENKQQWFIFCEHFKEEIEDYNLATIMRIRTNGAYSEENTIIVPKIIFLAVEIARNKEGLNESYKESFKTEYEKIRREGGNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6N5</accession>
    <name>A0A183H6N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002014">
        <property type="protein sequence ID" value="VDO35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6N5"/>
    <dbReference type="WBParaSite" id="OFLC_0000314601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000314601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000314601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000314601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18251" checksum="E4E23894BA93153C" modified="2016-09-07" version="1">SSPNDNGNSVNESTTVLRTKTTSSSSSVSNIIYEQPSTSFNYDTNTNVAANPVTESNPQINSSDKNEETSKNEPIPIYIRPSELCFDDVDDSGEILNEFFMPSSSTSSYEPAKPTTTSGTTLTVSGMSAGSNTMPIVTFAQLWNFNEQFDHKEAHPLSSQATSTTICPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H723</accession>
    <name>A0A183H723_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS3285</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01002151">
        <property type="protein sequence ID" value="VDO35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H723"/>
    <dbReference type="STRING" id="387005.A0A183H723"/>
    <dbReference type="WBParaSite" id="OFLC_0000328401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40313" checksum="E59A1688C29B3CFA" modified="2016-09-07" version="1">MTEAWVTLATSDGYAIGALVLAHSLKVQHTTKQLHCMVTSGVSQQLREELAATFDAISMVDVLNSEDTANLRLIGRPDLGVTFTKIHCWRLTQYSKCVFLDADCLVLQNADELFDHEELSAVADIGWPDCFNSGVFVYRPSEQTYSEILNFSLENGSFDGGDQGLLNMFFKDWRDKPAAFRLPFIYNMTSGAIYTYAAAFKKFGSQVKIVHFLGPVKPWQQTSNVHFSEHLAYWWSLFKSRLTSNLITSHVSSPRSSPRSSSQRTTEIIGTCGAPLSATISTTTDTTTTTTTTAVPVTTTPFTSEEDVPAVLLPRSGPPDPLCMRVFRCIPPSYGAWRPLRHPPTHLANQMAVFSLVSVLPILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H807</accession>
    <name>A0A183H807_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3618</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002483">
        <property type="protein sequence ID" value="VDO37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H807"/>
    <dbReference type="WBParaSite" id="OFLC_0000361801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000361801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000361801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000361801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25897" checksum="85234D814BD42EAE" modified="2016-09-07" version="1">MKERFLGNQAELCMQAYPNLQITCATAYDQRIVVSEHECRDLCLKMSAQTCQYNKIRTKSCVPSVTPNIGFLLFLNDDCDFGESKQANKNVTSKQSTFTAPGNNSINMVSQERKSLVLDDRIQEIRINATVETTKLNASIPYYSSRNKLQHEFRSTVTLSSSEGKFMIDFQSMVIILFTICFLLNYCASGFSVYIEAIDGIQVIDEGLATFQTRTPKICLHKCMKNKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8D3</accession>
    <name>A0A183H8D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3745</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002610">
        <property type="protein sequence ID" value="VDO37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8D3"/>
    <dbReference type="STRING" id="387005.A0A183H8D3"/>
    <dbReference type="WBParaSite" id="OFLC_0000374401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000374401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000374401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000374401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36999" checksum="376C66EB66D65530" modified="2016-09-07" version="1">MPRLPLISAGEYRHALNLFLEQKPMFLSHLDTKQLQKRIEEENLVGYCTNGLTEGEFLKRMFCIHIANFRNSTRAANLEDISCTDWITVLIEYLTHLDGSLRKWHYSMEYIRELVSQKLKKRYENALVNGSDTTMNADINDSFPHSRISDRTYKDKQKDCISYINNLVVNNTNSQKPARNEESVSSNVYTEYFIEKLTNLVESWILLFDEQRQRKFAKKLRKIMKKDEKLDSLQGLVEKMISSLEDEQKLKLSKKYRKIMKRFQKMQEAKNSESSVHYKLNEAETSGKNYTEGGETTNYADHSGGITEIAEDKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8E9</accession>
    <name>A0A183H8E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3764</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002623">
        <property type="protein sequence ID" value="VDO37677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8E9"/>
    <dbReference type="WBParaSite" id="OFLC_0000376001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000376001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000376001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000376001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8504" checksum="F9557E5F4B2281FA" modified="2016-09-07" version="1">MFCHSPKCMKFSEVLPEYLSCSPGILPKMHHMQLPFISSPPEATMTAITSPDFHAVLSSSLLSLHFRTFILLYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8J1</accession>
    <name>A0A183H8J1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3803</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002663">
        <property type="protein sequence ID" value="VDO37789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8J1"/>
    <dbReference type="STRING" id="387005.A0A183H8J1"/>
    <dbReference type="WBParaSite" id="OFLC_0000380201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000380201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000380201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO37789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000380201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10874" checksum="40F37BC6FA081FD6" modified="2016-09-07" version="1">MISIRTSDCENNFDENFDVENLSGSLEDLVGTFDQKISHCFKNLNETTEEIAPIQVRSQDEIMSESQSVFFFLTQNFPLHVTKTLNIHFFCFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9M3</accession>
    <name>A0A183H9M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4185</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003081">
        <property type="protein sequence ID" value="VDO39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9M3"/>
    <dbReference type="STRING" id="387005.A0A183H9M3"/>
    <dbReference type="WBParaSite" id="OFLC_0000418401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000418401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000418401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ezrin/radixin/moesin C-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000418401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23301" checksum="D360DDABAD2BC92D" modified="2016-09-07" version="1">MSLERKARDAELWAHRLMHETERHGYDPYLCRAHLYNSEPSWPQDWLSTYALPVPQRYISHHRLVSSSSSGDGGYVQYLDDDPNFTAAVTPIIKTQPFIKKQALLNCPPPDPSSNQMMPNDLLSLRKEIEKSRADYNEKKKSLQEKMTEFRNEIENLKVVNRQSEHDRIHATNLQMGIDKYSTLRKSGAGATKTRVQVFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB70</accession>
    <name>A0A183HB70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003740">
        <property type="protein sequence ID" value="VDO40884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB70"/>
    <dbReference type="STRING" id="387005.A0A183HB70"/>
    <dbReference type="WBParaSite" id="OFLC_0000473101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000473101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000473101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000473101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35461" checksum="276C6F5C3C4E1CAC" modified="2016-09-07" version="1">MSDAVLSILHYKGRVFSALANGSIAVFHRDANGGWSEAGYHLITVGRATSSVRSLSIVGDLLWAAYRNCIIVIDPKELIVKKVFAAHPRRDSQVRHMQWVGDGVWISIRLDSTLRLYHAYNYEHLQDIDTEPYVTKMLGTNNLDYSYLRITALLAICRRLWIGTGTGVIISVPLPECKLSNENRVETNVETHSHIENVRGPGGLIRVYGDVANEKLTPGSFIPYCDMSRAQLSFHGHKDSVKFFLAVPGVNTDISLPTPAESLDYIGKPDKSVALKMLVVSGGDGYIDFRMGEEEDVIDLANAMRARDMSHLIVWEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC89</accession>
    <name>A0A183HC89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004211">
        <property type="protein sequence ID" value="VDO42059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC89"/>
    <dbReference type="WBParaSite" id="OFLC_0000510001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000510001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000510001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000510001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9799" checksum="7A0BB346F19C8247" modified="2016-09-07" version="1">MSDLRQWTAILSGASLSKFSIRRMVKSRELGRREKLISHHASFVPNTSGAFTLDEKANLVNSVRLPTPKLEEYDICNEDYGNKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD48</accession>
    <name>A0A183HD48_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5411</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004631">
        <property type="protein sequence ID" value="VDO43048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD48"/>
    <dbReference type="STRING" id="387005.A0A183HD48"/>
    <dbReference type="WBParaSite" id="OFLC_0000540901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000540901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000540901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000540901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17798" checksum="F995E41DDA75E6BE" modified="2016-09-07" version="1">MQRQVGYGRGFVFSPAWLRFVCCVVVSSLWCEDFPEFWELVRFLMKLAHESVTIELKNGTLVTGTIVGVDVAMNTHLRTVKMTLKNREPVSLDSLSIRGNNIRYIILPDTIPLDTLLVDDEPRKKPTRGGRGRVASARGGRGRGRGRGGPRGRGGFRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE28</accession>
    <name>A0A183HE28_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5741</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005100">
        <property type="protein sequence ID" value="VDO44169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE28"/>
    <dbReference type="STRING" id="387005.A0A183HE28"/>
    <dbReference type="WBParaSite" id="OFLC_0000573901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000573901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000573901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO44169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000573901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="18148" checksum="FC7F55835D2AC22F" modified="2016-09-07" version="1">MLIGSFSYLVTMVLVAGKRIKIVKKRTRRFTRHESDRYHRLRPNWRKPKGIDNRVRRRFKGQRRMPKIGYGNAKMTRHMLPNGFRKVLIHNVKVSFCPIFIGYNWFCLFFFGMSCSERSTQCYSSKEYPMHMLFFFLLALYGFTLSLLMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HER8</accession>
    <name>A0A183HER8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5978</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005434">
        <property type="protein sequence ID" value="VDO45000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HER8"/>
    <dbReference type="WBParaSite" id="OFLC_0000597901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000597901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000597901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000597901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24313" checksum="ACC5560830888EF4" modified="2016-09-07" version="1">MLKHFQSSETDEDVLQEEGKSQMRRYKAYTVMQNYLSIMINLCRMEIVVSLGFLIHGFTCPGFAQESAYQGACHMNVVAAVVGATTGCIGLGVVHRYRWKMMLIMWLVLCIISAVGNLLSVITTGIWLDHLSKMKSRTGLVNGLSGMMLLCSVAVGVCFILNAVMICHFWNFNSQKYQAVGKISKRPRSLIRRTSRTSSGTERKARSEKFAKGYHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF27</accession>
    <name>A0A183HF27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CNDH2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6090</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005594">
        <property type="protein sequence ID" value="VDO45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF27"/>
    <dbReference type="STRING" id="387005.A0A183HF27"/>
    <dbReference type="WBParaSite" id="OFLC_0000608801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000608801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000608801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000608801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34779" checksum="9D6C5F5AB53C07D7" modified="2016-09-07" version="1">MDDDIAESYGCMTADWLNEQLADFMYTFENDADGEFVAKANVLSKQYHKKGEDFISELIAFATNQKQTHVNFSMLDSFEQQILHKALQNCKDESFNMSHTKTAFSEHNRKSWLDESSIAENMSMDFSDENFSLPISGENFALPEKYLSFTPIRKSVPDVAYQNRKDSGKIIGKFTGKNFTTKRNDATKGNNVCKVVVEKMYTDDYKNLFQYGAEKDLEQIEALVSRVRNLCDIIKEENETLVDEEQTDSLSLIRTTYSGFIVNNTEDPLDASNCSLQCIDQDATVINLDLSNLKAYSLFPGKVISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF88</accession>
    <name>A0A183HF88_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="4">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6150</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01005695">
        <property type="protein sequence ID" value="VDO45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF88"/>
    <dbReference type="STRING" id="387005.A0A183HF88"/>
    <dbReference type="WBParaSite" id="OFLC_0000614901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000614901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000614901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase C-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000614901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17805" checksum="FD3EB711D24B889B" modified="2016-09-07" version="1">MLENELLYSETFPMSDEALKNDFTVPLGKAKIEREGTDITLISYSIGMLTTLKAADQLAKEGISAEVINLRSIRPFDFETVKKSVMKTHHVVTIDNGWPFCCLGAEICMQLNESEAYDALDGPVYRVTGTDVPMPFSESLEAAAQPKPADVVKMAKRSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFD5</accession>
    <name>A0A183HFD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6195</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005757">
        <property type="protein sequence ID" value="VDO45744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFD5"/>
    <dbReference type="STRING" id="387005.A0A183HFD5"/>
    <dbReference type="WBParaSite" id="OFLC_0000619601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000619601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000619601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057448">
        <property type="entry name" value="BCL-11A_Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25491">
        <property type="entry name" value="CCHC_BCL-11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCL-11A-like CCHC zinc finger" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000619601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28734" checksum="B4928ABD60F11607" modified="2016-09-07" version="1">MTERGKTVTTSIAGKCNDLQQTSAITTTTTTTTVINSTANVTDESELFLSKVYDDINRSTPSIAAMNKSDGSVPLASTDSGIDSCIDVDHEMKDVITLRDDEEASPSENCSDDIAAVPQSRNSIHYDRIVCGDCHAEFSLSTFVEFVEHKISRCDSKRMPLDEFLANISPAHPSSETLRPGRRRFLVSYRHPSAEMSDSCSRCITSSCGNDQNASCTLSANEDQQKRNKRVDATTDTDTLGEYVIFLYYLLLIGRSSINRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFQ8</accession>
    <name>A0A183HFQ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6319</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005939">
        <property type="protein sequence ID" value="VDO46141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFQ8"/>
    <dbReference type="STRING" id="387005.A0A183HFQ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000631901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000631901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000631901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO46141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000631901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23319" checksum="02F35F2B10B1D4F6" modified="2016-09-07" version="1">MISCDSSFTDVHMKASVIGTIKKIATGYIAGARVVMKNVSDFFRTAAVSTLEFYGHNAEDLFYEEEEDAMRRNLPPCDFDSSRTVSSPISRQFSLRSHAERYSIVYKTSMRHRSIMIDSDDQDLSKLCLLYGKQDRNNSVQTDDKSQSSGHTTSLKRFLSPDKRSSADDLIRRSSTASLRSISSGDSEKNDSGQPTNYEIFNPGILIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG01</accession>
    <name>A0A183HG01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6415</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006080">
        <property type="protein sequence ID" value="VDO46480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG01"/>
    <dbReference type="STRING" id="387005.A0A183HG01"/>
    <dbReference type="WBParaSite" id="OFLC_0000641201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000641201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000641201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000641201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8205" checksum="3A2F9CAA0A62A95D" modified="2016-09-07" version="1">MPSRCVSTPQSLNRSIPCSYESNQFTTVRSTSYIDGLKPALSSRTRTAVVGPNMVQRSREGSSYDYGITAEKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGJ7</accession>
    <name>A0A183HGJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006390">
        <property type="protein sequence ID" value="VDO47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000660801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000660801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000660801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000660801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12810" checksum="455BA2EF39846DC0" modified="2016-09-07" version="1">MKICSLVVIIFIDDGRYQWFIYTAIFLICIVLIVCTFLTLVVLYVGIKNTYNIELVFNLIAFSLCLLAGSLLTYDLIQMVSGNFAHHQYLTPTYIGRDSWKNRIAVCTVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGP7</accession>
    <name>A0A183HGP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006466">
        <property type="protein sequence ID" value="VDO47361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGP7"/>
    <dbReference type="STRING" id="387005.A0A183HGP7"/>
    <dbReference type="WBParaSite" id="OFLC_0000665801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000665801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000665801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000665801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30202" checksum="547F5D812B8EE827" modified="2016-09-07" version="1">MYSYLFQLEILRRLRDHKVSVECMDAMRCLFECCSPLQFDGTAISVLVDMVIMSIKNSIDDNQFNRCYKLIKLLKIVADAYPHCFVNAPTLESLVKLIELESFSEIEGLLNLVITISTELKQNELLAKDMVAEYVKHCERISLDGTPRAAKYAVRCISKLLKTEQAQAKLENIFQNSLLHLSTSDPQCCTALKALSSCVEVDAMQFCNELFEILKTKIMDLLLDQCSNEETFNQQNCMMNSADNRTEQISDGEVCDENYVEIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH87</accession>
    <name>A0A183HH87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6847</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006763">
        <property type="protein sequence ID" value="VDO48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH87"/>
    <dbReference type="STRING" id="387005.A0A183HH87"/>
    <dbReference type="WBParaSite" id="OFLC_0000684801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000684801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000684801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000684801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15304" checksum="C44E36651FBFA750" modified="2016-09-07" version="1">MLQFWIWQRGIAAPCAVASGDARLSGSREEKKKMDTIEEAPSKADIQTVFRKLRSIPSNKECFDCGARNPTWASVTYGIYICIDCSAVHRNLGVHISFVRSTTLDTKWTWLQLRAMQVGGNAKAVCFEHFFFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH93</accession>
    <name>A0A183HH93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6854</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006772">
        <property type="protein sequence ID" value="VDO48123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH93"/>
    <dbReference type="STRING" id="387005.A0A183HH93"/>
    <dbReference type="WBParaSite" id="OFLC_0000685401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000685401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000685401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000685401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="9662" checksum="1D45D60BAE9F1DFF" modified="2016-09-07" version="1">MGKSLPSVGPPGPPGRQGEMGPMGIAGLPGDKGRPGESGPMGPPGDEGNAGPYGKPGNVGEPGPEGEAGSKGSCDHCLTPRLPPGYYLETITQSYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHQ6</accession>
    <name>A0A183HHQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7018</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007058">
        <property type="protein sequence ID" value="VDO48899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHQ6"/>
    <dbReference type="STRING" id="387005.A0A183HHQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000701701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000701701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000701701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO48899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000701701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16237" checksum="58CA76E8148501AD" modified="2016-09-07" version="1">MYIIHWKAKYLVSCFPTINVNEYPGHIGGRCLASFDCDPSGPKVCVTLAAVRDCFADCPNAADEVTPFTECPVNKVLCDSRMRRGCGKCVRMEERDMQCSDRRWRNICSELEHFKCTSTDNCVLPHWIGDGIDDCADGSDEGNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHS8</accession>
    <name>A0A183HHS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3361 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007088">
        <property type="protein sequence ID" value="VDO49001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHS8"/>
    <dbReference type="STRING" id="387005.A0A183HHS8"/>
    <dbReference type="WBParaSite" id="OFLC_0000703901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000703901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000703901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO armadillo-like helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000703901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24745" checksum="49396355F2F33DE5" modified="2016-09-07" version="1">MDHPGLLYWSQVSDEFISKIAENITGRAKQEDNTLLVSSLNIIDLILNSKNEGKMNLVLREVPFESLIRHLEKSDERVILNVLTLMNSLYNKARDHVKSDIIEHLHVTPFRCAIEKSVLRKGKQLDVGIEQQLIIIQRIQLNKLLEKALRIPTEAEIERVFQLKLLHGESNKGMHANVMSEEKRTEFLNFTEAVIQTPPGSLALETILSFVTHCADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHU2</accession>
    <name>A0A183HHU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007107">
        <property type="protein sequence ID" value="VDO49082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHU2"/>
    <dbReference type="STRING" id="387005.A0A183HHU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000705301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000705301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000705301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000705301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21122" checksum="933BE0BFACABF578" modified="2016-09-07" version="1">MEPGCRFDQTCCRDLKRANELRRFCQKEIRSKLSAITGFPREWSAEGRLAQPRCLFAFHRHLLRGDSNSSRKRELRNKLVEKLEQQIYRNMQIYGLLSDKECPCSLPKSVEQYVYLFSAAESSNDVIRGSLLMLIERGNTKEGNDGTEKKGIILHGLEQNCDCFFRIIETLLQKILHFIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIE0</accession>
    <name>A0A183HIE0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7253</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007436">
        <property type="protein sequence ID" value="VDO50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIE0"/>
    <dbReference type="STRING" id="387005.A0A183HIE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000725101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000725101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000725101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000725101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27639" checksum="A20EAF7A689530F2" modified="2016-09-07" version="1">MARLASWRASSENDTPDALRWLDRSLIRLCQKFGEYHKDDPSSFCLSEKFALFPQFMFHLRRSQFLQVFNNSPDETSYYRHILMFENVLESTTMIQPVLFAYSFNGPPEPVLLDTSSILPDRILLMDDYFHVLIYHGQTIAAWRKMNYQEDPQYSAFKQLLEAPIADATTILQERFPMPRYIVTEYEGSQARFLLSKVNPSLTHNNPYAAEGGAPVFTDDVSLQVFMEHLKKLAVSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKF3</accession>
    <name>A0A183HKF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7967</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008678">
        <property type="protein sequence ID" value="VDO53410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKF3"/>
    <dbReference type="STRING" id="387005.A0A183HKF3"/>
    <dbReference type="WBParaSite" id="OFLC_0000796401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000796401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000796401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO53410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000796401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20761" checksum="AC4805E0888179C0" modified="2016-09-07" version="1">MLIDICLLANVIRFFIISLLTNPWMVLPLQALQGLTLATTWASASSYISLIAPSQLKQTAQTFLMLLYHGIGKGFGSIIGGWIIKSAGTRLTFQIYSIIAILVLGIHYGMNRLFKYDDIKYSHDFDDDDDMPVAPQGLPLHHGESKLTDAFNQTSVTNTNYGTIETEDPTQEAYDRYVQLPPVNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKV1</accession>
    <name>A0A183HKV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">POU-specific domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8111</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008918">
        <property type="protein sequence ID" value="VDO54047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKV1"/>
    <dbReference type="WBParaSite" id="OFLC_0000811201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000811201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000811201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000811201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16815" checksum="2CC963EFBBA0BCF6" modified="2016-09-07" version="1">MYLTKFIRFQTLGGIPAANSSNTESLSSPTTSSPSRSSETSTVDTVASTGLLGSYQKTDSAIPILSALSAGTSSNPDQLQPLGIPITAFNPLLTPAMMAAQIGLLSTPNTLLSMMQAATAQNSLMHHNRCNDRNGQIVPTMLHQLSALHSNQVRFLHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL96</accession>
    <name>A0A183HL96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8256</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009190">
        <property type="protein sequence ID" value="VDO54812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL96"/>
    <dbReference type="STRING" id="387005.A0A183HL96"/>
    <dbReference type="WBParaSite" id="OFLC_0000825701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000825701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000825701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000825701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15678" checksum="AFAC149AAF1B3349" modified="2016-09-07" version="1">MKSRVNTGSGNVWNENKECNYNNIEFNFMKTSVNFETSMSKQGHKARANLPAGGFLAIGRDVPSTSEVSRTKPQVHKRELPQLSSGVLKKPRLDFSGKILTSTPSTSSVKRAGVDDSRWRSFCAEVGVFTKFHTNIKIIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLB6</accession>
    <name>A0A183HLB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonsense-mediated mRNA decay protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8276</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009222">
        <property type="protein sequence ID" value="VDO54904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="OFLC_0000827701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000827701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000827701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552562" evidence="3">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000827701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17479" checksum="D9343E79B4C10F4E" modified="2016-09-07" version="1">MYVCVRRFLGFLLELMLLLPQQLTILLLQLNQREMTEEEHSDSRTEDDYEEGDEAYDDEGTLDEEEMLQLEENYQDELKLLEDDANLSIEELRQKYCNTVAEEEYDDSQSSSTSNDTRKSEGTYDTTVNSDFTESGTFLYLHLSHLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLX1</accession>
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        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8484</name>
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    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009633">
        <property type="protein sequence ID" value="VDO55881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="OFLC_0000848201"/>
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        <source>
            <dbReference type="EMBL" id="VDO55881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000848201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4539" checksum="9ACA4F0719289E07" modified="2016-09-07" version="1">MHSSNNILHELTKEELRMIDDLRTVIPTLETVDNGYIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM93</accession>
    <name>A0A183HM93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009877">
        <property type="protein sequence ID" value="VDO56482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM93"/>
    <dbReference type="WBParaSite" id="OFLC_0000860401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000860401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000860401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="VDO56482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000860401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3608" checksum="2C818153489E8463" modified="2016-09-07" version="1">MDEERDDSLIVDFLDRDGAVEILRDVRRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMH8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="4">U17</fullName>
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    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8693</name>
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    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
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        <lineage>
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            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
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            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010046">
        <property type="protein sequence ID" value="VDO56934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="OFLC_0000868901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000868901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000868901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000868901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14367" checksum="A4ABF11F710618E0" modified="2016-09-07" version="1">MPLKEALIQHFEAGRRKSCVPTCRIPDKRDFMDSNPPRTTDDFYRNYDPWIGIGTAIMLALFFILIAFKSFLTWLLRRTTIWRYQYQKKYRKKQLINNHITDSTTIATTATPIIDNGHIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN43</accession>
    <name>A0A183HN43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS8905</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDO57954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN43"/>
    <dbReference type="STRING" id="387005.A0A183HN43"/>
    <dbReference type="WBParaSite" id="OFLC_0000890401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000890401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000890401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDO57954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000890401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20699" checksum="11C4FA6DC55CE56D" modified="2016-09-07" version="1">MFFRLYNELPIELTTRVLQNIVQLSSLRRTLFSNPERQTYLTHIVKGVKGIMEQPDKLRQQESFHEFCRIVSRLKGNYQLIELMKIEEYPTVIALLADFTEQSLRAYEFSANSTYYLLSFWQRMVSSVPYVKAADPHLLNLYCPKITATYVESRLQYARAVARSIHLYERNIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNA6</accession>
    <name>A0A183HNA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8971</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010573">
        <property type="protein sequence ID" value="VDO58218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNA6"/>
    <dbReference type="STRING" id="387005.A0A183HNA6"/>
    <dbReference type="WBParaSite" id="OFLC_0000896701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000896701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000896701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000896701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="40" mass="4949" checksum="63F6599BAD6C39EE" modified="2016-09-07" version="1">MRDVISDFQRHKMGQTRRKRKVIVGDTFRWPQQVVPYFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP39</accession>
    <name>A0A183HP39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011155">
        <property type="protein sequence ID" value="VDO59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP39"/>
    <dbReference type="STRING" id="387005.A0A183HP39"/>
    <dbReference type="WBParaSite" id="OFLC_0000925001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000925001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000925001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000925001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10394" checksum="CCF0166E8A9AF0AD" modified="2016-09-07" version="1">MQTFFVDSLALILHTHKGDFREGDLNYSSSGGTICAQRYGYPHTEKMCLSLWILFLLVLNKSGSCYATKGNFGRNVRAVGHSEEYIKQVQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPD1</accession>
    <name>A0A183HPD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related GTP-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS9345</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011358">
        <property type="protein sequence ID" value="VDO59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPD1"/>
    <dbReference type="STRING" id="387005.A0A183HPD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000934201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000934201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000934201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000934201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16380" checksum="1AE4940A087CA3ED" modified="2016-09-07" version="1">MSKRKVLLMGKSGSGKTSMRSIIFANYIARDTNRLGPTMEVEHAHVRFLGNLVLHLWDCGGQEAFMENYLASQKDQIFKNVQACVLIYVFDVESRELEKDYRYYQSCLEALIQNSPNAKVFCLIHKMDLVSEEHRDQVKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPR5</accession>
    <name>A0A183HPR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pilus assembly protein PilS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9477</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011647">
        <property type="protein sequence ID" value="VDO60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPR5"/>
    <dbReference type="STRING" id="387005.A0A183HPR5"/>
    <dbReference type="WBParaSite" id="OFLC_0000947601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000947601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000947601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000947601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7134" checksum="DC01DA28BF9DCEED" modified="2016-09-07" version="1">MNDGFRLGLMRNRRFNESFIRRAIICSLAIFLISAIQVIRLNSEEQQQLQKRLISLQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPV1</accession>
    <name>A0A183HPV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9512</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011729">
        <property type="protein sequence ID" value="VDO61109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPV1"/>
    <dbReference type="STRING" id="387005.A0A183HPV1"/>
    <dbReference type="WBParaSite" id="OFLC_0000951201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000951201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000951201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552598" evidence="2">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO61109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000951201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28486" checksum="873982866224BD90" modified="2016-09-07" version="1">MASFLSSLLCISTSSTTTSSTSSAFQPHPSPQIVSAIQISVENITVFILARHSLYLILSIEQSRVDALSSSMTLSMLVLNFKILQGIVTNDKFISWNDSEQIKSKEISSQFLLLFLIAIVSSFEFLHIECGNSDRLMMRFSLLPSSWEVILLAESIVNLVWSTTVHIIFLETFRSLKQISGLFEQKTSSKASQSFHFNIETSSPVIIKFHLPRNHVMCWEVPSLHIRYMNHIIIEMPQFTASLDCHPILTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQC2</accession>
    <name>A0A183HQC2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="1 6">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9683</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1 6"/>
    <dbReference type="EMBL" id="UZAJ01012145">
        <property type="protein sequence ID" value="VDO62445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQC2"/>
    <dbReference type="STRING" id="387005.A0A183HQC2"/>
    <dbReference type="WBParaSite" id="OFLC_0000968301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000968301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000968301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO62445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000968301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17148" checksum="A5E4848AE9574166" modified="2016-09-07" version="1">MIEGTPGAPYGGLLACFNVVESNMISRRAEVTRFLEKGESIMSISFPALGTPDFTSPPYEPRPDDVNGFGCSLFFPDEVIYGGHPRFRNLVRNIRQRRGEKVAINVPIYKDINTPSPYQVIFRQFYVRIIILRYNSDFEKYMKCISYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQK6</accession>
    <name>A0A183HQK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012328">
        <property type="protein sequence ID" value="VDO63108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQK6"/>
    <dbReference type="STRING" id="387005.A0A183HQK6"/>
    <dbReference type="WBParaSite" id="OFLC_0000976701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000976701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000976701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000976701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6372" checksum="F4FED873B1256E40" modified="2016-09-07" version="1">MLPYGFPPIESSTDLPICLYETNGRLIYGAEEELHEMEANALVCYILNFRINYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQL8</accession>
    <name>A0A183HQL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9784</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012364">
        <property type="protein sequence ID" value="VDO63235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQL8"/>
    <dbReference type="WBParaSite" id="OFLC_0000977901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000977901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000977901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO63235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000977901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5445" checksum="F6498C904110B768" modified="2016-09-07" version="1">MQKEDRRLKFHILGSPSTIPKVARNQHRFPLIRIHKKPIGIIRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQQ3</accession>
    <name>A0A183HQQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS9816</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012470">
        <property type="protein sequence ID" value="VDO63602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQQ3"/>
    <dbReference type="STRING" id="387005.A0A183HQQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000981401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000981401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000981401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO63602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000981401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20337" checksum="F999F291F3DBA017" modified="2016-09-07" version="1">MQTLQQGVFPARLPYPSSSLPNNDNNNTTANSNVNQIAWNIHLRQVALNLMTLQRLQAASNAERIIPEKQSSYSMHIASVAAASSREGTMQPCSSCNKFFINAYSLEQHMLEQHNQCSKISGSEKQFECKQCGKAFKRSSTLSTHLLIHSDTRPYPCDYCGKRFHQKSDMKKHTYIHTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRF7</accession>
    <name>A0A183HRF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10069</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013037">
        <property type="protein sequence ID" value="VDO65599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRF7"/>
    <dbReference type="STRING" id="387005.A0A183HRF7"/>
    <dbReference type="WBParaSite" id="OFLC_0001006801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001006801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001006801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001006801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7735" checksum="9E5C9BAA3F264208" modified="2016-09-07" version="1">MAMKKQASLLSFFTRSPNPKNTLQSETIGNQTTSILKNTTPSKISEMQKDVNMENDIQVEEDTMKSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS23</accession>
    <name>A0A183HS23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013537">
        <property type="protein sequence ID" value="VDO67298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS23"/>
    <dbReference type="WBParaSite" id="OFLC_0001028401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001028401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001028401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO67298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001028401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6072" checksum="B5D8A11F3909DABD" modified="2016-09-07" version="1">TTTITSTVQLRSLSKDNFHRKLKSEIGGVGLRNKAKLIPRAERSDQLLAMYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSP8</accession>
    <name>A0A183HSP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10507</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014071">
        <property type="protein sequence ID" value="VDO69014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSP8"/>
    <dbReference type="STRING" id="387005.A0A183HSP8"/>
    <dbReference type="WBParaSite" id="OFLC_0001050901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001050901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001050901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001050901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11298" checksum="3BE0BE853A584F74" modified="2016-09-07" version="1">MRQVLEAAAFMHENGVVHRDLKPENLLYYDQTEDSKIMISDFGLSKIEESGVMATACGTPGYVAPEVCFNFFSLNSIQWITVHCPTILFCREIFGFLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUR8</accession>
    <name>A0A183HUR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase subunit 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015962">
        <property type="protein sequence ID" value="VDO74920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUR8"/>
    <dbReference type="WBParaSite" id="OFLC_0001123001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001123001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001123001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001123001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3546" checksum="ABB417A4334C4871" modified="2016-09-07" version="1">MNLDIDKNYAKALFQVKLINFFFNSIKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVN6</accession>
    <name>A0A183HVN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016802">
        <property type="protein sequence ID" value="VDO77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVN6"/>
    <dbReference type="WBParaSite" id="OFLC_0001154801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001154801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001154801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001154801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11964" checksum="BEC18DE5E61EF2F3" modified="2016-09-07" version="1">MNSTQAVLEDTPTAGLISLLIAFAIFTLCIPTLLAHDILPQKNNSYLIKSTTNLPTNFSIPDPDSITNKYTIGLSKTFVSNDCFLLKLNLWLTGILMKVIFAKSLNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW74</accession>
    <name>A0A183HW74_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11729</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017343">
        <property type="protein sequence ID" value="VDO78724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW74"/>
    <dbReference type="STRING" id="387005.A0A183HW74"/>
    <dbReference type="WBParaSite" id="OFLC_0001173601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001173601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001173601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001173601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14591" checksum="83B416039EFC9A3E" modified="2016-09-07" version="1">MDGVRLCKQIFNSVVAQYPVVEEESEKDDMLINAWNWLTYSGIDTYYDALLGMNEIMREFFYVDKLDKARKLLQRSRKLIDKILESFSHVIDTDDSVEPKLSRAITEYKAYECYLVSFRFHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWC2</accession>
    <name>A0A183HWC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein 24-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11778</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017488">
        <property type="protein sequence ID" value="VDO79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWC2"/>
    <dbReference type="STRING" id="387005.A0A183HWC2"/>
    <dbReference type="WBParaSite" id="OFLC_0001178401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001178401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001178401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001178401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="4990" checksum="35183A2682CD27A4" modified="2016-09-07" version="1">MLTFPGGAAIGSVPQMPGAYAAAVPGGPYGGTSPATNAYGTSMYPSSGSYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWS6</accession>
    <name>A0A183HWS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017878">
        <property type="protein sequence ID" value="VDO80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWS6"/>
    <dbReference type="WBParaSite" id="OFLC_0001193801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001193801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001193801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001193801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8981" checksum="0298E8057FBA45B0" modified="2016-09-07" version="1">MPPYQAICEYILIISNLSFHLTTISDTRNLSFLMYPRMCSGECEPMNPANFQKGGKFEYCRSQNHINKKRLIDHVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXC7</accession>
    <name>A0A183HXC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF503 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12135</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018458">
        <property type="protein sequence ID" value="VDO82203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXC7"/>
    <dbReference type="STRING" id="387005.A0A183HXC7"/>
    <dbReference type="WBParaSite" id="OFLC_0001213901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001213901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001213901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001213901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10911" checksum="928505D49114FE4C" modified="2016-09-07" version="1">MVESITGEYRLTVLYDDDKKADEHAAEILKTLNLLRQFILGVSIHSSNGFEVTFLLPADQRENFPSLFQQLEKSTDQLGINTFGVSVTTMEEVFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXJ7</accession>
    <name>A0A183HXJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">I-set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018647">
        <property type="protein sequence ID" value="VDO82810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXJ7"/>
    <dbReference type="STRING" id="387005.A0A183HXJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001221001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001221001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001221001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001221001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="6783" checksum="3A320EEB3CA3EBCD" modified="2016-09-07" version="1">MGVSMVGFTKDLLLSNVQQTDQGLYQCIASNAVGERSIFIGLVIEAEIDSVITNLEVTVDHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXQ9</accession>
    <name>A0A183HXQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12271</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018841">
        <property type="protein sequence ID" value="VDO83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXQ9"/>
    <dbReference type="STRING" id="387005.A0A183HXQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001227201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001227201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001227201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF116">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001227201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14891" checksum="C215134FBF702CD9" modified="2016-09-07" version="1">MLNSIFDNTPAKLLKEIILYDDCSDYDTLPINHIINYGNHVRWPMEKIITRRSNERLGLIKAKVFASRIARGDVLIFLDSHCEVTPLWIEPLLLPIQEDSTRLVSEEIYVITYLLFLILDTYREILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXS7</accession>
    <name>A0A183HXS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ICA69 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12284</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018887">
        <property type="protein sequence ID" value="VDO83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXS7"/>
    <dbReference type="WBParaSite" id="OFLC_0001229001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001229001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001229001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001229001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15648" checksum="7277FEBD981D3575" modified="2016-09-07" version="1">IYTCLLLTTHNLCCNFVSDQQAAGPAAPNKLKRLLEISKTSNGDEERLKVPKNEFESPDESGSYTDYLKQVFLNSTSADFALNDKDLETKIEPETPTETSTTVGSPNGVSTTIISTEELHFPSSSNSESGKFFIFLYKGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY06</accession>
    <name>A0A183HY06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonium_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS12368</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039831">
        <property type="protein sequence ID" value="VDP11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY06"/>
    <dbReference type="STRING" id="387005.A0A183HY06"/>
    <dbReference type="WBParaSite" id="OFLC_0001236901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001236901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001236901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF114">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001236901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47591" checksum="EE4BFBB079E8CCB2" modified="2016-09-07" version="1">MPGGTTSTNFINTNYPLFQDVHLMTLVGMGFIMVFLRRYGLAALSINLLLTSHAIQWALIVRGFFSHEFANVGRFSISILDLITADFVAITVLITMGAVLGKLTPVQYMVMSAIEVPVAVAVEHLILRYLKVIDIGRSMVIHCFGAYFGLAVAKVINKREMIAHQHEGSSYNSNIFAMIGTLFLWAFFPSFNSALAIPEDSRHRAILNSYLALCSSTVCTFLISQMLDHENKYRFSMTHISNSVLAGGIAIGTVANIILEPFYALLIGCLGALVSVLGNNYIRPIGARVFGLHDTRGVGSIHGLPGILAGILGFVFTAVYEPTRYGTGNVTHIYPAMSNSKEGREIFVQAGYQLAALVIVLLVSIIGGAVTGLILRLNCFNRIHDKEFYSDGEFIEPPEDYDFTTRIISKIDHIELTEHTALNKESSSSVGPSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYK9</accession>
    <name>A0A183HYK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12571</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039871">
        <property type="protein sequence ID" value="VDP11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYK9"/>
    <dbReference type="STRING" id="387005.A0A183HYK9"/>
    <dbReference type="WBParaSite" id="OFLC_0001257201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001257201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001257201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07594">
        <property type="entry name" value="BAR_Endophilin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001257201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29778" checksum="8F01887D425750BB" modified="2016-09-07" version="1">MVDRFTASYSMDFNFKKIASDASGFFIRAKQLTEETFLKAEKTELDAHFENLLQRADKTEEHTKRLLSAMESYLQPNPTIRMEEVFYEKLELRKENRLNNLEQLAQAMNEAGNEFGAGTPYGSALLKAAQAEFKLGAGERDFINSCASNTLLPVRRFLEGDMKTIQRERKVLNTKRLDLDAAKSRLRKAKSVEAQSSAEADLRVAQAEFDKQTEITKLLLEGIQTAHNNHLKCLRDFVECQMSFYALAHQHMADLQRELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZJ9</accession>
    <name>A0A183HZJ9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS12911</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01039972">
        <property type="protein sequence ID" value="VDP12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZJ9"/>
    <dbReference type="STRING" id="387005.A0A183HZJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001291201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001291201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001291201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDP12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001291201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25433" checksum="A73DC111901301E0" modified="2016-09-07" version="1">MIDRAETVLHSHFGDFHYWEARRSMRYAKHLRLVADEFRQERLNSDDVRDGTILSDSWKATRKEHGEAQGGDFICVHWRRGDFVRSHNADIPSISGTAEQIAAILRKENLTTVYLCTDASAAEVTTLINLLPSNVQVERFLNDSSLNDGEVSIVDQWICAHARYFIGTHTSTFSYRIQEDREILGFKPEKTFNRLCPDSDKDCEQPARWTIVYKESSNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZN7</accession>
    <name>A0A183HZN7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12949</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01039987">
        <property type="protein sequence ID" value="VDP12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZN7"/>
    <dbReference type="STRING" id="387005.A0A183HZN7"/>
    <dbReference type="WBParaSite" id="OFLC_0001295001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001295001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001295001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048564">
        <property type="entry name" value="CYNS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002773">
        <property type="entry name" value="PRK02866.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21291">
        <property type="entry name" value="CYNS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001295001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17816" checksum="D7AE954A79ACD9D0" modified="2016-09-07" version="1">MTRKWQSAKILTAGTMKSRQEVTNHILSAKVQNGITWKSVAAKIGKSKEWTTAACLGQMAMSKQQAEKVAEIFDLPESALSWLQTVPQKGTPGIPSDPVLYRLYEMMAVYGPTIKELIVEEFGDGIMSAIDFNLTVAREKNEGGDRVSLVLSGKFLPYKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I073</accession>
    <name>A0A183I073_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CACTA en-spm transposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13135</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040058">
        <property type="protein sequence ID" value="VDP12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I073"/>
    <dbReference type="WBParaSite" id="OFLC_0001313601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001313601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001313601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001313601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10161" checksum="F66102F5DBB5C2B0" modified="2016-09-07" version="1">MTFGNRSLDINDGSSPEVPLPPTNGIKAAAPTTLFPGKGHANANDKMIARRKECLLDFCERNHWIHIVTEIYEYRETICLMLLRPLPDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1A5</accession>
    <name>A0A183I1A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13517</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040240">
        <property type="protein sequence ID" value="VDP13959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1A5"/>
    <dbReference type="WBParaSite" id="OFLC_0001351801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001351801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001351801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552722" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001351801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="6830" checksum="B209BF6327D29174" modified="2016-09-07" version="1">MCVCVVCVCVCVCVCVCVCVWWNAYVTLGGSSRCCSSSSSSRDRNSIDRGCMQLGTSNLRLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1X9</accession>
    <name>A0A183I1X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">26S proteasome subunit P45 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13741</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040369">
        <property type="protein sequence ID" value="VDP14541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1X9"/>
    <dbReference type="STRING" id="387005.A0A183I1X9"/>
    <dbReference type="WBParaSite" id="OFLC_0001374201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001374201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001374201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="221"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP14541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001374201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49889" checksum="5CD2C21DA418BA3B" modified="2016-09-07" version="1">MGQQQSGFGGKREDRGGGDADKEKKRKYEAPIPTRIGKRKKKGKGPDAATKLPTVTPHTRCRLKLLKYERIKDYLLMEQEFIRNQERLKPQEERQEEERSKVNDLRGTPMAVGNLEEIIDDQHAIVSTNVGSEHYVNILSFVDKEQLEPGCAVLLNHKTHAVIGVLADDTDPMVSVMKLEKAPQETYADVGGLDQQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGCPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKMVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVLMATNRIDSLDPALIRPGRIDRKIEFPLPDEKTKRRIFQIHTSRMTLANDVDLDEFIAAKDELSGADIKAMCTEAGLLALRERRMRVTMDDFKKSKENVLYRKNEGAPEALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2C3</accession>
    <name>A0A183I2C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13885</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040448">
        <property type="protein sequence ID" value="VDP14894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2C3"/>
    <dbReference type="STRING" id="387005.A0A183I2C3"/>
    <dbReference type="WBParaSite" id="OFLC_0001388601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001388601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001388601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP14894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001388601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24232" checksum="1239DEF8C4CBB336" modified="2016-09-07" version="1">MATCRIIDTCNESCYLKEQTMAATSQSGLAVAIALWGRKPPKHRINCLQCFDDGATIITGADDGVLILWEKCDGNLQAKMMLLGHEAPITALSATDTASNLTRFVSASADGQLTLWDSSDGRSIDNTFMSHIHRRIVPHRTTNGSFSMCGLYCIGDYAEVVVIDTQDLNILFTLNSRVEPDWIAAFTIVSHSDIQDTVIGMTTCGMIKSWVLFDLDKKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I394</accession>
    <name>A0A183I394_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neurexin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14206</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040674">
        <property type="protein sequence ID" value="VDP15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I394"/>
    <dbReference type="STRING" id="387005.A0A183I394"/>
    <dbReference type="WBParaSite" id="OFLC_0001421401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001421401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001421401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001421401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49931" checksum="FB485CFF356317A2" modified="2016-09-07" version="1">MEVSTYLRLRYSCGISQGCATNMNKDFCASSPCKNFGRCENGYNSFRCDCSVSAMEGRFCDKEPEFVDFSMDDAPSLLLPKSIESEAETIECKFRSSNERSVLLDTKSIKSPDHRILLLLIKGELELHLNFEDSHHVFNWGSNLNDDRIHTMRIKRRGEKLLLFLDGKWEHNYFLPSSKIVLDIDEIAAGHSLHLTSSSHFTARANSTLGERFRGQMIKMLFNDYDVLKSVRRRSSLENPLVKTIEIRERYKIRSRKAKYSSVSFKKPDAYAIINDERLANIGTNYRISFKFRTLSSSSLLLAFVTNSTHSRDSASLELFHGRIRYTYSFSSRTETVLSSALPDEQVLNDFKWHSVLVHQDVPGFHGCISSLRIGGEYLDILKDAKETSGVVKGCHASSYARCSSKQCLNRGKCIQKWNSIKCDCSMTTYSGERCDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3T6</accession>
    <name>A0A183I3T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14398</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040826">
        <property type="protein sequence ID" value="VDP16880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3T6"/>
    <dbReference type="WBParaSite" id="OFLC_0001440601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001440601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001440601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001440601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18099" checksum="756DA18267DFEF97" modified="2016-09-07" version="1">MDEYDERLVPKDENERWIRAPPNCNPFDMRASFTCSSLSCRARITQATYGRSRLNTATGIERPSSGGSAMTVRGNGCRGRKCTEQVRSNDSLLTDCRQHEDGCFSSHLRWLSMKEFSENRSQFDSPPVVYVPDRIESREEKSIRTSLCNCMENGTKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4V1</accession>
    <name>A0A183I4V1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS14762</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041168">
        <property type="protein sequence ID" value="VDP18642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4V1"/>
    <dbReference type="STRING" id="387005.A0A183I4V1"/>
    <dbReference type="WBParaSite" id="OFLC_0001477401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001477401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001477401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDP18642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001477401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13530" checksum="A083CB61DD297B41" modified="2016-09-07" version="1">MSGRGKGGKAKSSAKAKTRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKSRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNIHAVLLPKKIAGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I665</accession>
    <name>A0A183I665_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS15227</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041796">
        <property type="protein sequence ID" value="VDP20922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I665"/>
    <dbReference type="STRING" id="387005.A0A183I665"/>
    <dbReference type="WBParaSite" id="OFLC_0001523801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001523801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001523801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP20922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001523801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17939" checksum="32674F555996FE83" modified="2016-09-07" version="1">MSMTQEIIELENSHVSTSAGEHANDIIMGSEDATTMDNECSKTELRKLKSGRWWKSMRKERSSAVVKVKPLKSSWERKMRAKAELENVRKLQQEVRDKLAAKKAAKIEARKEHERRQKENERKAEIVQVIKNTQKLKKTKKKQLRRIEKRDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6L6</accession>
    <name>A0A183I6L6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15378</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042036">
        <property type="protein sequence ID" value="VDP21591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6L6"/>
    <dbReference type="STRING" id="387005.A0A183I6L6"/>
    <dbReference type="WBParaSite" id="OFLC_0001538901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001538901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001538901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP21591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001538901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15457" checksum="7C792F2C330ACEAB" modified="2016-09-07" version="1">MELEATERMPTVEGASSSHDSSRNQFAFWMLGLCNNFAYVIMLSAAEDILSVEDSRKASSKSIDDPCQSSIVHRQCQPLSTGSVLLANIIPSLVVKIFYPFVMHRIPFGMRHLFTVLLQISSFLVVAFSQNIPMGLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I723</accession>
    <name>A0A183I723_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15535</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042315">
        <property type="protein sequence ID" value="VDP22411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I723"/>
    <dbReference type="WBParaSite" id="OFLC_0001554801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001554801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001554801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP22411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001554801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13460" checksum="85D1381D677AB00A" modified="2016-09-07" version="1">MTGCGADQLINLVYERAVEEVNELDKKRQRLEVEKNKKIAAKEDQQLQKKKNISARPSINFTALVGYKRLQHAGPHESRTTVSRFYNFDKLANISGGFRLYLRLMTDAILNEIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7U7</accession>
    <name>A0A183I7U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042936">
        <property type="protein sequence ID" value="VDP24013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7U7"/>
    <dbReference type="STRING" id="387005.A0A183I7U7"/>
    <dbReference type="WBParaSite" id="OFLC_0001582201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001582201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001582201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP24013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001582201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10351" checksum="FD4F7E74CFBE4106" modified="2016-09-07" version="1">SFQGDSGGGLAVLGSTGQWSLLGVLSHGTDCEELRQGYPPKSQVYTDISLYAMDIDIFTGYDHRPCQSRSDLTQWDCLVGRFVEGGDVVCESVGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8H1</accession>
    <name>A0A183I8H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043682">
        <property type="protein sequence ID" value="VDP26222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8H1"/>
    <dbReference type="STRING" id="387005.A0A183I8H1"/>
    <dbReference type="WBParaSite" id="OFLC_0001604601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001604601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001604601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP26222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001604601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11954" checksum="2C04A7ED0771675F" modified="2016-09-07" version="1">MKSKRSKTGKRGKRDRKSSGNCDYRQNVKNSDPVDVELQRWRTNRMNYLKSRVSHIHLKSASPVNIRKSTDERSKDGSPVTSKIAIATQSPLQITEVNFHLFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8P2</accession>
    <name>A0A183I8P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS16105</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01044095">
        <property type="protein sequence ID" value="VDP27262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8P2"/>
    <dbReference type="WBParaSite" id="OFLC_0001611701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001611701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001611701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP27262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001611701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12447" checksum="4D08A4273E460EB4" modified="2016-09-07" version="1">LYTKINIVVVVVVIIVVVVVVVVVVVVVVVVVVAVVVVVVVVVVVVVVVVVVVVVVVVFVVVVVVVVVVVVVVVVVVVVVVVVVVDVVVVVVVVVVVVVFIFVVFVLLLLLFLMLLLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8P8</accession>
    <name>A0A183I8P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS16109</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01044119">
        <property type="protein sequence ID" value="VDP27319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8P8"/>
    <dbReference type="WBParaSite" id="OFLC_0001612301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001612301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001612301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP27319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001612301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7893" checksum="2830DB5AD0592A8C" modified="2016-09-07" version="1">MKSCLMGMAIIRVRNYMIGWIYRNVSVGIDVIAIPVQNIEFSLQPIQYSWLQHELINFYPYFVVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7U7I5</accession>
    <name>A0A3P7U7I5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000364">
        <property type="protein sequence ID" value="VDO27489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H087"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="215" mass="24338" checksum="2091CC0B68B8C1A5" modified="2026-01-28" version="1">MATGDDIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLIFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLLGDPNLEFVAMPALAPPEVQMDPTMVAQYEQEIAAAANAELPDDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UTG0</accession>
    <name>A0A3P7UTG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002789">
        <property type="protein sequence ID" value="VDO38226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H8V7"/>
    <dbReference type="OrthoDB" id="5918422at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="118" mass="13006" checksum="81503741D9834010" modified="2026-01-28" version="1">MSRKRRPKKSRSAKSGLVFPVGRVHRKLREGNYADRIGAASPIYLAAVIEYLIAEILNAAGNVAKDNNKARIDPRHIQIAIRTDDELNKFLSDVTISEGGVLPNIPDALFPNVTTDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VB24</accession>
    <name>A0A3P7VB24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001188">
        <property type="protein sequence ID" value="VDO32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="84" mass="9838" checksum="D5BF62E91C1490E2" modified="2026-01-28" version="1">MHKENMSYGGRYSKLMKREMLNNEMNWMGELTIIKDQVGIEWFSQNGNLALSGLYILDIKNLLMYFDYMQISEASIGAKCEFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XJK4</accession>
    <name>A0A3P7XJK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000165">
        <property type="protein sequence ID" value="VDO25985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZ33"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="528" mass="60368" checksum="58C55B1A2671FA79" modified="2026-01-28" version="1">MSHNWIQQSAIPGSVRPVYGAQYPPLTEYDDFANGGGRTESTDNQHSNSGAKFQNYVDSVSDAWDVSVTLDERAACTSAAKVLERHASLVARDLIMPPVNPIPSKNSKVQAMQRLAIQKEPIPGTAVPTGSGGVHLSINLYPRLPEISVEYGRSPSSSVVSGSMMAHDSPTAQGHILALQRDHARFNRLRAQLGVHTSPSLNPNNDTQSLKNVDVDLEQLRKDCWMGIPHKLRPTIWRILLGYLPTSFERREVTLARKREEYWHYVEQYFHTRYDEQHQDTFRQIHIDIPRMCPLIPLFQQKVVQEIFEHILYIWAIRHPASGYVQGINDLVTPFFVVFLSEFISDDTEVGTYDVSQLPREQIEIVEADSFWCVTALLDTIQDNYTFAQPGIQRKVSQLRHLMSRVDKQLHRHLEAHGVEYLQFAFRWMNNVLMREIPLRATIRLWDTFLSERNGFSQFHGYVCAAFLRMWSKQLQAEKDFQGIMLLLQNLPTHNWGDQQICELTADAFSLMALFDGAKNHLAQDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XT79</accession>
    <name>A0A3P7XT79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001304">
        <property type="protein sequence ID" value="VDO32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XT79"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="108" mass="13021" checksum="5472F3120FAFD0EE" modified="2019-02-13" version="1">MRSKSNFSQDEILQLYEQLQLSGIPKVLSRFEKIIVSFCKEIQRQHDQNVQLQHVFESEREAHNRRMNEVENEIEQHIAEMQQHAREEVLNVAISCKIFKNHMTDFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZZ42</accession>
    <name>A0A3P7ZZ42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009002">
        <property type="protein sequence ID" value="VDO54282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857167at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO54282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="193" mass="22146" checksum="F45F9E435E287660" modified="2026-01-28" version="1">MQSYQAVIMIIIMTLLPLIFLAPMIIRDFLERKQQKMFQFLLEFRPKKFVFSQSSVSENSQFKKEKQLSQNVSRNREEIRAILSVRNHLSPREMLSMLCTSSTQQSSFCTARRNGERMMRSYQKSDKTDWNNISKMNLSSVSSSGSANTAKKQSTATVKFETSPLNRRINSEKITDLRTSSSLSSTAKSFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8API3</accession>
    <name>A0A3P8API3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040724">
        <property type="protein sequence ID" value="VDP16247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="79" mass="8664" checksum="95BEC388DA762F2E" modified="2026-01-28" version="1">MFMRVERRKARCDDGDIVDPESGEEPFIDDHEAQLATAIKLCHIALIHATAAVIVTATAAVQFGNQTVCKCSKQLQQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CIJ3</accession>
    <name>A0A3P8CIJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041739">
        <property type="protein sequence ID" value="VDP20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CIJ3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="233" mass="27529" checksum="EE80C4224E359D78" modified="2019-02-13" version="1">MQKALKERTSECDSLKKKVEKFERERSKVATELSNFQAKITFQHFRQQWENQKRALEAKQPMDVQMLQGQKRELTMQLNREQAEKQELFLQSLKSSEKNCTFFMANIIETFEVVQSQLNTDVRNLQEEMQRKNQEVEKAQDESKKLRLIMNNEKIQFESNIEELQRDLQMKSAALQSLMLAKQNNTTSEADSAMITRLTVENEELRGQIDEMENEVKKHVSEIEEMKSENENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F5H8</accession>
    <name>A0A3P8F5H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040880">
        <property type="protein sequence ID" value="VDP17183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="89" mass="10521" checksum="704551FD365D3665" modified="2026-01-28" version="1">MEFDRKISYRYLTPWYAECRIQRRGVTRNLTRKAQVKEDLRSSACDPSLYPSSTQSYDLESTSKILSTGTIKRMHGEDERFLIRIPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FE76</accession>
    <name>A0A3P8FE76_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041674">
        <property type="protein sequence ID" value="VDP20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8FE76"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="167" mass="19508" checksum="19A6B5D4A6141E3B" modified="2019-02-13" version="1">MLAFKNIASIISENKSFTDVLDKDNLPEFKYNNRVNVLEKVENNKGKIGGTYSILRIIPENIEQLKFLSTLYVTDDGMFHQFILILTANKYLRSKQEILPRRNKSFNEDRRLWDDNNRKSNIFLGEYHSFDGIISWLKNLEKQNPKIVTVISIGTTYEGRKIYGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXT3</accession>
    <name>A0A183GXT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyco_hydro_18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS43</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000010">
        <property type="protein sequence ID" value="VDO24320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXT3"/>
    <dbReference type="WBParaSite" id="OFLC_0000004201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000004201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000004201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000004201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10446" checksum="2208634FE969C25A" modified="2016-09-07" version="1">MVVWSVEEFYCCIGRSHFRRCQRRTNVMVVLSRCVRTSLSLLSNLKIAVPRTEELIIDRYYHYWGYPKDKNDINFVPFAVNKSTDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXX0</accession>
    <name>A0A183GXX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Replication protein A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS80</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000018">
        <property type="protein sequence ID" value="VDO24437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXX0"/>
    <dbReference type="STRING" id="387005.A0A183GXX0"/>
    <dbReference type="WBParaSite" id="OFLC_0000007901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000007901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000007901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="10">
        <location>
            <begin position="277"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="9">
        <location>
            <begin position="415"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO24437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000007901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="581" mass="66124" checksum="9A7DDA60B5124ED6" modified="2016-09-07" version="1">MHECFLGTACKYMQIAYSWRVCTIHNPLEMSVGFVTASGKGIMVSEKALQKARHLFEQLDDDDSSVQATVGNTDNGRCSNLANDDSISFTSFNTALRNSKRISSTFKSPVLKNPRLDNVSYSSSFNTPTKKISIAPEQSTPTTPKNSFCGKIGNVTPIKLLTPYCKNWRLCIKIRCVRGQHIFSFLAVDDGGVEIRVSAFGDTACKTATLICLEQMYYITRASVKMANRKYGRNQHDMEVVLQTDSEITKCTDRPHILSPKMNFEFVRIHNLQNFIDSEIDVLGTVISVGEMKQLKSKTGEELQKREIQIVDDSSYYVTINLWGQKAKTFPNEQYKHVLAVKGLLVRCFQGTISLVSIASSKLLYDPHFPEADALQFWYSENKEKIFKPASLNQVLSFHEHRWIKQLKPSLNSHFFNLTAMISTIFTENAAYKGCPTCKKKLLVEKDADLYICSKCGICNEYKYYYTLHMELFDFTGTIHVTAFDDCAQKLIGEQADEVAKFLKFDSERYQSFFKSVLFKPFMFRVSIQKKGNIDCSKAPVKTEQVHFWSVKDLIPMPFDSYCAFLERAIKFANFGISVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ53</accession>
    <name>A0A183GZ53_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS513</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01000176">
        <property type="protein sequence ID" value="VDO26060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183GZ53"/>
    <dbReference type="WBParaSite" id="OFLC_0000051201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000051201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000051201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="521"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="714"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1347"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO26060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000051201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1696" mass="192629" checksum="C093BEE5CCF253EA" modified="2016-09-07" version="1">MHIIVSGSVQNSLERASNFTINMADEIARVQQYEYRQNSNLVLQVDFNFTDRRGRDEPTGEVMPLTKDVLAGVKMGDKYQRAKAPVIDTKKAKKKKRTDANATGNNTTSHTLLGDSNTELMGLYKPRTQETRQTYEAILAYIQDAIGDQPRDILCGAADEVLAVLKSDKIREKDRKKEVELLLGSLTDERIAVLINLAKKITDFSVDDEKGKFDNQDEIDETIGVNVQFDDSDDEAEGDEGMEEEVKEEGSDGEDEGGVEAVFEETLKARYVDEDDENAAGERKGNLHARDIDAHWIQRSLSKFYKDPIVAQQKVNEVLQVLKEASDDRDCENQLVLLLGFDQFEFIKVLRQHRQMILYCTLLKQAQEGKERENIEKEMLSRPELHHILAELHETESADTVEAEREKRARVQQQRRIAEAEGGNDEGTTVGNWLQSRKVLDLNDLAFSQGSHLMSNKRCHLPDGSYRKQKKSYEEVHVPALKPKLFEENEKLVAITDLPKYAQPAFEGFKTLNRIQSRLCDSALKSDEHLLLCAPTGAGKTNVALLCVLREISKHMNTDGSIRVDEFKCIYIAPMKSLVQEMVGTFTKRLAPYKITVGEMTGDQQMNKEQFMQTQVIVCTPEKYDIVTRKGGERAYSQLVALLIIDEIHLLHDNRGPVLEAIVVRTLRQMEQNHEECRLVGLSATLPNYQDVGTFLRVKPQNLFYFDNSFRPVPLEQQYIGITEKKALRRYQAMNEVVYDKVMEHAGKSQVLIFVHSRKETAKTAKAIRDACLEKDTLSAFMREGSASTEILRSEASQVANADLRDLIPYGFAIHHAGMTRVDRTLVEDLFADRHLQVLVSTATLAWGVNLPAHTVIIKGTQIYSPEIGRWTELGALDVMQMLGRAGRPQYDSKGKGIMITHHSELQYYLSLMNQQLPIESQLISKLADMLNAEIVLGTINNVSDAMNWIGYTYLYIRMVKSPALYGISHEQAKLDPLLEQRRADLIHTAASQLDKANLIKYDRRSGLIQATELGRIASHFYCTHDTMQTYNQLLKATATEIDLFRIFSMSSEFRNIMVREEEKLELQKLAEYVPVPIKESLEESSAKVNVLLQAYISQLKLEGFALQSDMVFISQSAGRLFRALFEIVLWRGWAHLAQACLFLGFTVVRSIDKKNLSFERLYDLDQHQLGELVKMPKMGKPLYKFIRQLPKLDMTALIQPITRSTLRIELTITPDFLWDARVHGTAEGFWIFVEDVDGELILHHEYFLLKQKFCEDEHLVKMFVPVFDPLPPLYFIRIVSDRWLGSETVLPISFRHLILPEKYPPPTELLDLQPLPLSALNNKLFQSIFEQKNISVFNPIQTQVFRTVYEGNDNVFIGAPHGSGKTVCAEFALLRHFDNRPDAKAVYVTPMEDLAEKKFIDWQERVGTALEKTVVMLTGEPSTDLKLLQRGQLIIATPEKWDNVSRRWKQRKNVQAVRLFIVDDLHMIGGSNGGKHTPVLLFSEQTLLPVLEVICSRMRYMSSQLDSTVRIVALSSSLANARDVGQWLGCSSQATFNFAPNCRPLPLELFIQGFNLSHTASRLAAMSRPVYTAIVRHGGKLRPRPALVFVPSRRQSRSTAVDMLTMAHADGQSKRFLHINPQEPSFIRLLDNVQDKTLKETLSCGVGFLHEGTSVKDMAVVEQLFQSDAIQVCLYVNILCILCNIYHVYTCLDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZP3</accession>
    <name>A0A183GZP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fmp27_GFWDK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000259">
        <property type="protein sequence ID" value="VDO26763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0000070201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000070201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000070201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1693"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000070201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1715" mass="194963" checksum="5AC4883A064DA607" modified="2016-09-07" version="1">MRYQLQINIDDSEVILVGLIIRFIIDLKNNYFGLYDQLTDVGKINSDTPLNLLYGNVISGECERYRPLLLRLHLCIGKIKGFCLVHNSKMNSAMDYCPEVGVDKIVLEIVKDAYGAMVQVGFGIASVKFKPSSGFSNAADGLLVLETFSFRAQAFYSDLDVPWDAATLEYGWLMEISVGQLLVQCNSRWGYCCITIAVLAQCIESLAVLAVCSDDKLLVPEKYDFCIHMNDRRTCPYAALNLVHEKARIQNCETEENLKYKSLRISIEQLSVSIMEEQSAFQFELSPIRLAHCNCHNGSFCSNILLKLPSVQLKQFAFVLGKDIEQWIECGSISLNDISFDVSLPYEISEAHLFLERKNFLNKHDKHTKRLYFLWDDAKSCACFGYVWFFGPVDTVGLSLMRELNKPLWGSNTNLEHVKLVIGQSIIHKDRWIINTKYLETQKSLAIIEESRKKETKSERKASSDDSFHSAFSSADVNVYHHMVGPILSSTVLHESYASFLSVYKNEITRDNDSKFGFFRKITAGINELTLIKQEAKQKQAMKSDVNTADLPVDANLSDQHTMNINGILGSQLHIFITPLALEVTQRIIEQISAGFMLMNPVFIVQHLYTLCTFRHHSQPLTNASKSGSNNEKSQSYLQGSIIFPDINIVFFQCGMIEKTIRSSSLEDSVSRLTRNSKKWLPRMEFTLKSHAQFLQLVESWKLDFAYNKSFSLKYSTNWNQLSLDNRFNGYDLRVVIEGELPDLMLKVNNNEVNNKLHGSAIQDQLSLLIGPCRLTIGLCKPIGQTTSVEWPFFDVFAPCITSWIYAIDRLSESLTKNIAAVDEWIDFALIKLLLEVMDCNNSQLFIFEKSCFADVQVYNKAAASCPSCMLTTILLRYAAQEDLSDYWQQVDYLEIRHQLSKTRRKQALVALLSHWQTIICSQVKISDIKLAQKYLKHNLKSPKSSHEVHINIDSNQMSSAIDKSSGNSSTRSTVDFHQMDLYHWVLAKHREHKEASTRNKTARKLLDDAPVNAMEIALYAFFWSFYEVGLFQARELESSNSNILLPAANIDAKFLVELISLKIDILEPKMISASNVNYLSTTRHHLLHLDSLDMIGQIHTESRFDELKLKPTRISIFLSYNSSVQNIRTLFPFVAVCLFNDLCRVIRSCTSAFARLKASRIYDTSKETIFVSKSPSNTVASELDNTNSTYWLHNVIDKLQDYFGSRTKITQSNEEFLEIKVDGSMDIKVAVLEMTLTHLYISATLKKTRLEHINRRDKIKDNKILDELNASIQRANLILSEFVMGHDAKHIVSFLVKTSSLRFERERCVNGLMGSRIKVLIGDVEGDTPIHAQNLHEVVLRNVSQLNEQMTRLEYNIPTPVGEYSAHLQQRQGVMVVNFEFLISSIELSAQLLPSLKVKYRLDQAESCGNTGPASKFTGRIKSHVVHFTVIAPSIDEKRTSSLNSDTFTLVLPHISADGAYRMAEKIEHIDEMGDENFLFREGGYIDVILTVGKLEHVFTTDLLNQILFAEQCFRTELISLIDRIIGDRTVRPSTPLEQIPSQDPFLFTITLRGETAPWLQLTASTPTSIAVRLTFDNITATLTNRWREKKVESKTKRIYGKAVIGVSTKLGLLVKTAMFEEIETELQEFATFMTQVTLQNKNSSVPSAHSYVVTLNRPILLIKSSAIDKAILLWLNYKNTYDFWHEERKKMLKSSRSLPLTSAHVSTPLVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZW3</accession>
    <name>A0A183GZW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS773</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000298">
        <property type="protein sequence ID" value="VDO27015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZW3"/>
    <dbReference type="WBParaSite" id="OFLC_0000077201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000077201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000077201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF70">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552317" evidence="2">
        <location>
            <begin position="16"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="234"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO27015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000077201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="676" mass="79758" checksum="FEAD5B8FC22C4FC0" modified="2016-09-07" version="1">MILISIELVIVISQADDISAKRDIEKELISSLSPRCTRHLVKVVSAYQNSSLTPSGALKEFYTAFGHGKSNEFFTDSRFQFRMMLCFELAGEEHFLASRTPTTFCYRYDPKQYRSVAHTVCFPMLCLKEQNKFWNIYEKVLGIELPESDNSVSTCINSRRQKQWWMESRPIFMLFFIILLWTIVFLSTIYQIKYKPEAKTISERIFVAFSAKQNIHMIFKAPKNRSKVITCMFGIRFLTMIWIVIGHMFAFVAVRCSKKILKLFYSFISPYIENVDEYFHDIADNFANQWLSNFLLSVDVFFVLGGTVNAYGFFQQYKQMNTKPTWTSSKFWLNFYVHRIIRLWPAYCCTLIVVYFFNSLFYRELWPEINHNIQCSKFWWQNLLLMASLFEHRCMRWAWYLSTEFIFYLFSPIFLLALARNQNRGYLLSIFCIALSNAGRVYVMYFYNMPPTQLGWNTPPIYNSNFMEQFAMMYIKPQYRAAPYIIGLLLGDHLAKIQAKELSDKRHSATFVACGWILAIFFAFISVYGLYPILINLKWEFYYLIYGAFHRTTFAVAIAWLIYACHNGYGSFVNTFLSSKLFLPLSALCYTVYLIHLPIIFGSYLHINFPYHYETKFEILCIALLNLFIAYFFALQISLLSEFPLLNIEQSIQNYYKGKSQKVDEQEVTNKERARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0K3</accession>
    <name>A0A183H0K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000425">
        <property type="protein sequence ID" value="VDO27882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0K3"/>
    <dbReference type="WBParaSite" id="OFLC_0000101201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000101201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000101201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000101201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8871" checksum="A85ECB563C7C9811" modified="2016-09-07" version="1">MSGEQVILESTHLHFCRTSGHLLHPYFTTSTRFAISKIKRLYCSAVKRTDKSMSKVFQISRIDDNIRVNRIEKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0U4</accession>
    <name>A0A183H0U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNOT1_TTP_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000474">
        <property type="protein sequence ID" value="VDO28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0U4"/>
    <dbReference type="STRING" id="387005.A0A183H0U4"/>
    <dbReference type="WBParaSite" id="OFLC_0000110301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000110301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000110301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000110301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20687" checksum="FBEDCC7AEB15087C" modified="2016-09-07" version="1">MFHYISRAFQEICDSPIAIDDGKYRGFGLLFNAFSRNSYNYILKPNIIECLVEHIEMTSKHKVNLATKSMHKFYTEIFSKECFHLQKLVRLCNEDRKGLPQHLEISSAQVQPYDALCKKALGCMYGQVIGDSLGSRYEFQPASIVQQMIIDDSVQSFLPIIGGGPSRLLPGQKPLISLEKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V9</accession>
    <name>A0A183H1V9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAU2 chromatid cohesion factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cohesin loading complex subunit SCC4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1469</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000697">
        <property type="protein sequence ID" value="VDO29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V9"/>
    <dbReference type="STRING" id="387005.A0A183H1V9"/>
    <dbReference type="WBParaSite" id="OFLC_0000146801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000146801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000146801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000146801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="597" mass="68127" checksum="C582723095953742" modified="2016-09-07" version="1">MLKWKNQLMSVMENYLPERYLFDQAAILLLEAAEFFRAHNPPKYKMAIKCLKACFKTLMTHEMTSFVNFQIGKLYFYYTKNIELARHHLEQAYHGMKEAGAEYTKYRIEIACSIAEVYMQLKIFEPVKQLLRKESAHSRDFPLIHARLLFLLAEIHGAMNDWNSASEIVEAGASLFNQLNDPALECYFRLSSAMIISMDLSREEELMKGIMEVSEKLVILNADNACLDYIKAFCCTVQICFFISAGLLKSTKICLRQLQTLVQTMKLTYGETTSIILPTFDWMGKETLIALTYVLTVIQSLQTCQIERAHKYHSIAIRHITDMRRLMAKSNWPVIRRGALDSLAAFEIILLENISAAQLMLARPLETINVLGAMMERMRQSTDLFNHFEAQLHTLLGMYCWFVHLPDDAERQFQAALRTAKDTESWTVVNLSLAILYLMTCREADFYGLFERITPGKLQSSSSLLKASAHFVHALHSYLHSRLQEAKSHITDSVTIVRDEGVPRIQALATLLSAKLVAVDVPDMLIAANNFATKSSDHSLALWLNQIIYETQMQYGHVEQAKGVKIKFDQMQAHISQAIQDAVNSPAHSLIQVDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H291</accession>
    <name>A0A183H291_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1601</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000784">
        <property type="protein sequence ID" value="VDO30110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H291"/>
    <dbReference type="STRING" id="387005.A0A183H291"/>
    <dbReference type="WBParaSite" id="OFLC_0000160001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000160001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000160001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO30110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000160001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37332" checksum="A87354462ACA7486" modified="2016-09-07" version="1">MADKKLSEKLPQPGEIIVTKKAEYESIKLLGKGGFGAVYQVKRLSDAAVFAMKCELMDVRKRVLLMDCTVLRGAQSLGSKHFCEIIDRGKQPTRFRFIIMKLVGRNLWDLRIERPNQRFTLNTALKAAEQCLEAIEHLHTVGFLHRDIKPGNFAIGRPEANEHHTIFMLDFGLCRQFSSGSKDLRLPRATAPFRGTTRYASIAALRQMEQSRKDDVESWLYITVEWTAGSLPWRKLKGPDKEEVLQWKEEVREGEAMDDFFKQCPKREFSTIMKYIDSLEYDNDPLDWDPDHKYHGPIINLNERQSKQAKDRRNLATAGTQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2U7</accession>
    <name>A0A183H2U7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS1807</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000924">
        <property type="protein sequence ID" value="VDO30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2U7"/>
    <dbReference type="STRING" id="387005.A0A183H2U7"/>
    <dbReference type="WBParaSite" id="OFLC_0000180601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000180601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000180601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000180601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18699" checksum="228567BEEAC97167" modified="2016-09-07" version="1">MVITQSVQVFGRKKTATAVAYCKKGRGLIKVNGRPLEHIQPEILRIKLQEPLLILGKERYQDVDIRVRVNGGGHVAQVIFILIFLKFVACEAEKIDIIYAIRQALAKAIVAYYQKFVDEQSKKELKEQLVSYDRNLLVADPRRREPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H312</accession>
    <name>A0A183H312_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaoptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1873</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000977">
        <property type="protein sequence ID" value="VDO31084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H312"/>
    <dbReference type="STRING" id="387005.A0A183H312"/>
    <dbReference type="WBParaSite" id="OFLC_0000187101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000187101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000187101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO31084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000187101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="625" mass="71942" checksum="E66C48B4A4B0AED5" modified="2016-09-07" version="1">MTMERSISDIPTLENLSLARNRLQQLRKATFVNLNNLEQLDLSYNQLRTFDFTFLAQSLVNVKHLDLSHNHIITIDLHSAKRTLMYLNLAHNHLQSIGKNMLYDFGQLKVLKLDHNELIEVQSNAFAMCKWLTELDLSHNHLRILHKGTFTKQNIYENLILRNNAIISLDINTFGANNVHKLDLAYNEIKKIPQHAFSSIQNSLTNLNLKGNRIRSINVDDFDGMENLTELILADNHIEIIEEAAFSKMQKLTKLDISHNPIISWNPHAFRGLSNAIEILNLANTGLFSLPKIDNHGIRLLNISNNKIQEMNSAQLINNRKLATFDISYNNFKELDPEMFAELVELKHLNISGNPVVIVTDRHLRSLYNLETLRLCNMEELLRLPEPHSFRHLRHLRNLYIYNFPHIQVYNISDILKHLPPLRILAAEIRETRLTTQMYSADLRLLRKIVITGKQLFKIETGAFAQLRGYKLDLTIRDTGIKIFPSSIFNTLTAISFLSLSLQNNYLQTLEPFPHTKPPVLNQHGTILYNLQLTNNPITCDCRLNWIGEWIEYYQSLNAAYEQPLNDTRCADQAGGGSTLYNAYTSTNHVVCTADNVTGSCNSIHFLSHLLFSLLLNILNYLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3E6</accession>
    <name>A0A183H3E6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001074">
        <property type="protein sequence ID" value="VDO31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3E6"/>
    <dbReference type="WBParaSite" id="OFLC_0000200501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000200501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000200501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000200501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9275" checksum="94394CB2695BF439" modified="2016-09-07" version="1">FFFAVHCKYSEVSVRLGRNENHSVPICPSSVSNRYEKLKQNIIKCEGLVCNRCRCNVEMGYKLSNDTDQAECVLICPKTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3V9</accession>
    <name>A0A183H3V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2-alpha kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2169</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001190">
        <property type="protein sequence ID" value="VDO32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3V9"/>
    <dbReference type="STRING" id="387005.A0A183H3V9"/>
    <dbReference type="WBParaSite" id="OFLC_0000216801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000216801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000216801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552380" evidence="2">
        <location>
            <begin position="27"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000216801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61259" checksum="D91F3D86BD987214" modified="2016-09-07" version="1">MRSAIASRITGTLILFFAILFRTSLTHDDEIAFVEDDVENVELFPKRSTKQASVECCVTGSASFINKHYLLASTIDGKVTAMDIDKNGEMVWTVDADKVPLLSSSFNKQKLIADNLPYILVPSLDGSLYMFNVKSSSLSLIPLSANARVMIGDDEIAGGTFVTSTGVDPLTGEIRYRCTAGKCMQYEATANDSSLYTLIMRKNTQVARAADPVTGAERWNLSVGEYDISLVSSDHSLRFEQASVPAHMRFLLEPPSGTVSAVDSCGNLKWEKQLSSPVARAWQLSRGRIFEISLFSSETISALSDFSGSGHQFIAKYEAPFYFGTVNSEPYIIPSELMREELRRTSTDMQAQYYPQTLDSSHYSRAPFLEDLKVGDLIRRSYKTTRGAVETNQIDSLQDSTALKSLTCNMYDAVTIAGSKKLKENIETKGDYGWYIFKPLHKPCQKNYPFQEIDRKEERSSYNHLCRRKNVFEGLKQIAYEPVSGWWKIVALFLTLIAASLAVVIIFYWQQIRHLKLFVLLHDLRKKSHAHSRTDARNLIAISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H491</accession>
    <name>A0A183H491_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EIF-3c_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS2301</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001293">
        <property type="protein sequence ID" value="VDO32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H491"/>
    <dbReference type="STRING" id="387005.A0A183H491"/>
    <dbReference type="WBParaSite" id="OFLC_0000230001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000230001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000230001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552370" evidence="5">
        <location>
            <begin position="17"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit C N-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000230001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="57140" checksum="120D0F5C331679E9" modified="2016-09-07" version="1">MICWLAWATGDFAALGRWMVVVSGMTSKKMSKFFKGAVSSSDSSGSESSDDEPYVPIKRPQAAFAYPSDSEDEGQKRVVKAQKDRKFEELKDLIKQAKNSRNIKDMSKLLSTFEELCKVFEKTKVVLTRQNMSTPRFYVRILVELEDFVNEQWDDKEARKTMSKANSKGLTALRQKIRKYNKDMEMEVNAYRAEPDPVGYSSADNQDEEDEQEEVENEEEEEKNKPYSDLKDSDEWSSDSNASSDSDSDLDLEGKQMEDLRKFFLKKEFKEGGEAEGKEKRQAERAQKQKEQKEREAKEKIEENENDDTWVAVPTKEEKMRQLFDAKTEINHEVVINKLQEVIAARGRKSTNPKHYVRSLQELFRIADEHKLGTGVLVKILFAIISALFELNARISDCMDYSSWSKTLGATNSLIDILNEYPDVVLSIGINEDDENIQDATKPYTVHGSVLMSVHRLDTELTKILQNADCHSTDYIEKFIFIEYFKLFSDLQFYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5G7</accession>
    <name>A0A183H5G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2727</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001636">
        <property type="protein sequence ID" value="VDO34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5G7"/>
    <dbReference type="STRING" id="387005.A0A183H5G7"/>
    <dbReference type="WBParaSite" id="OFLC_0000272601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000272601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000272601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000272601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="543" mass="51002" checksum="CBA84E58B0294A4E" modified="2016-09-07" version="1">MVLGEPGEPGARGYPGNSGAPGQPGFPGMKGEKGLSGPAGPRVSLCNGSSPGKEGRPGLPGPPGFKGDRGLDGLPGVPGLPGQKGEPGFPGRDGMKGIRGPPGPPGGGDFADGRPGPPGSPGREGQPGPPGVDGHPGPPGPPGPQGPPGGPGLPGLPGLEGLPGTKGIKGDAGIPGAPGVPGPPGLPGPRGPKGEPGPRGMDGKSIPGLPGKDGRPGLDGLPGRKGEMGLPGVRGPPGDSLNGLPGPPGLRGPPGPKGYDGRDGAPGLPGLPGQKGERGGSCLTCVPGMKGEKGSSGYPGLPGPQGERGLPGLQGAQGPPGDDGLAGAPGRPGPPGPPGKDGIPGLPGQKGEPTHMILRPGPPGYPGQKGEAGFPGLPGQMGSPGKVGSPGLPGLPGIPGPKGEPGFPGLTGKPGKDGIPGLPGLKGAPGYGAPGLPGLPGQKGEAGLPGVPGAQGPVGPMGPPVAESQLRPGPPGKDGLPGLPGPKGDSGYPGAPGKDGARGLPGLPGPKGDAGLPGPPGIVGLPGLPGPKGNAGEQFNLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5N7</accession>
    <name>A0A183H5N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001700">
        <property type="protein sequence ID" value="VDO34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5N7"/>
    <dbReference type="WBParaSite" id="OFLC_0000279601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000279601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000279601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000279601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7207" checksum="305903A5C07ABF89" modified="2016-09-07" version="1">MCGRLCHLGDIASHLDDIASVNGQFNLQSIRLGFGEPEQEQARETLVEVVFGMGVKDSSNNPAFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H663</accession>
    <name>A0A183H663_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2974</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001857">
        <property type="protein sequence ID" value="VDO34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H663"/>
    <dbReference type="STRING" id="387005.A0A183H663"/>
    <dbReference type="WBParaSite" id="OFLC_0000297301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000297301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000297301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="511"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000297301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="643" mass="75060" checksum="9B441A1755487C32" modified="2016-09-07" version="1">MSLSFVDDHFQFAEMNIRYTGNMEETMAMVRRAVRMGYDCIVINTDIGQMMQESVNLVIFSCKSNEPPRKKKKKSGKERNVIPDPVIINCAELDTSMLEANGKRLRIFSRLTTTISSSTEVHLLMHHSQLKKYDLIAVRPSDDQILQTLSKKGDFVDIITYEQASTSVGWLNKSKIIQLCINDGITFEITYADALKDSSQRREVLTNGRQLLMSTKDGDGVVIASGAERMIDIRAPYDAANISVLFGIRPEFARKFVASNAKKALLRAESRKTLKGGVLVQTKEDLPKNLIVRLNVIEKIMRIPEFRAQLEIVTDEIEEKSKKDEIREETKKKLNVFVRVLNYVYTIMQCILKKREKNMWKKFLEFYRDSVRNVWRKVVWKLQKKLRINARWPVLWMENKLKSLPSRQFIQTLNASQQEQLSGIITEVELLSRCYNYFPEYLSDSDWKRLLQCETQKQRFNYIKFCHQKELKELKYETKRQLKVSEKLGTSKPTSGFAMLVGTTQRKRIADQRRLMNHLHNLQLNPKPALIVDCRFLNDLSSQALSQTLIQLSYLASENRDRRRSWPLYFFNFDIKNERILEGRDRYLSLTNSPRNVSLTISSSSYLNFFSPEEIIYLSPHAEFDLEEVCFKIEVQKKFKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7E9</accession>
    <name>A0A183H7E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002270">
        <property type="protein sequence ID" value="VDO36415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7E9"/>
    <dbReference type="STRING" id="387005.A0A183H7E9"/>
    <dbReference type="WBParaSite" id="OFLC_0000341001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000341001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000341001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056044">
        <property type="entry name" value="DUF7627"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24628">
        <property type="entry name" value="DUF7627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7627" evidence="1">
        <location>
            <begin position="135"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000341001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40770" checksum="FBBAC10ABC8E6CC5" modified="2016-09-07" version="1">MEMDLQIYTMSDDGPTNTEPEVNSSATYRLDSSFDCDTIEKLTKLTIARNDLRPKSFGERKVREKNTRIARGHQMFKNIESALNDGQMKKKLQGKKEKQLVNRLQVGEMVLPGEFSSPKTRKPVSSSAITVDELISLFDLACNDHCSMHDSVKFKNTVSDANLCLSDEDWNRFACHVANIGIHGIRGFAVTAVISATRQKGFRSAFAQEINVLMSDYVLFGGKVGVGLPEFVAHLLIANWPREHARCNLESNDILFCIVSSIKGWLETITGETNEIEEIESNCACALYDVCRFAQRKFWMKWPELVDECYAAVRDGITLNITLTKEARKALLDTIIMMHEWTSRHAKTLVNVSTQTCRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7M6</accession>
    <name>A0A183H7M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS3489</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002339">
        <property type="protein sequence ID" value="VDO36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7M6"/>
    <dbReference type="STRING" id="387005.A0A183H7M6"/>
    <dbReference type="WBParaSite" id="OFLC_0000348701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000348701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000348701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="4">
        <location>
            <begin position="323"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="2">
        <location>
            <begin position="567"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000348701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="622" mass="71421" checksum="74B8725050279471" modified="2016-09-07" version="1">MSDPKSPIIDFYPDQFDTDLNGKKNDWEAVVLIPFIKEDRLLQAIAIKDPLLTDEERQRNVHGPHLLFSYDSTSSHILKSTFPGVFPDIQECTAKVEKIEMNHFRISRDQIVHGLLPGVKLDVVFPGFPTMKYIPHIAELHYADIKVFQQPSKNQSMILKITNRPEFEKDMLEIASDLIGTEVHVNWPVLQKVFVQELWTAHKKYSKTSEEEIICDILSEEEQNKYSSYVSITRKNEFERKGIDAGEQKGLVLVRTMQGMRKCFEEQQVVIKRSYTDINNAIPVSLSLVVQNALEDWDSACSVEDVYPINAQVFISSIESKYYGFFGFIKENHLATKGTLIVSCKISSAADVNFYDVIANYDNYSLKWYSVYEVARFLHTTVDVVGRITGCVYILLDESNSVSSRNTPLNKINIGLGLKFTKRNQIMPDFTRRSSEGHWLYSSRAFDIIRSYKMKYPGVFKYLEKLDSFQGHIHIKQIFLEFKENELNTKLKELKDFLHTIVPNDALESADDTFVDSGILKELEKRIQIAISKNTSKQTCKRLAVKPRAVFMAELCKGEIMPDPKAEFRLLDRVICVKKLRTAPFGEFGTVIGLVNTRSGKKIDVLFDKPYFGGRIMRLVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8H7</accession>
    <name>A0A183H8H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AP complex subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3789</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002649">
        <property type="protein sequence ID" value="VDO37751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8H7"/>
    <dbReference type="STRING" id="387005.A0A183H8H7"/>
    <dbReference type="WBParaSite" id="OFLC_0000378801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000378801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000378801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO37751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000378801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23562" checksum="B6C0FF9836B934DD" modified="2016-09-07" version="1">MKLAEEKRLSERMIKAILVFNNHGKPRLLKFYVHYPEEEQQHIIRETFQLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDRCFENVCELDLIFHVDKVYHILDELVMGGMVLETNMNEILLRIQEQEKMEKEEAGIAAAPARAVSAMKNMNISQHIKDFKLTDINLSNIKKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H982</accession>
    <name>A0A183H982_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH-type with G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS4043</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002921">
        <property type="protein sequence ID" value="VDO38689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H982"/>
    <dbReference type="STRING" id="387005.A0A183H982"/>
    <dbReference type="WBParaSite" id="OFLC_0000404301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000404301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000404301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20384">
        <property type="entry name" value="Tudor_ZGPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF1">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="15">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO38689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000404301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49099" checksum="062A3E81ABA1721E" modified="2016-09-07" version="1">LIESIGSSLDSEKSFHLDIVFPIIYALVLITENETTSVTEQDCSESCTSADMQDSDQLIGMHCLAPYNRIVDRAVHFHDAVILDFVENSNTEESDLKVKVLYGHPLETAMKACEYFLDDRCNYGNECRFSHGEEVSFSALQEYQQPDISMVREGSLVLVLGDNKLWSSARVTAMDDKKLAVRFLLTGKEIAVDQNKVYPIPQLADNAEDEVAAEDLATTSWKEYKQERHGNVTIGDIGDWEKHTRGIGMKLLLKMGYRAGEGLGKRSDGIVHAIQPVIFPKNKSLDICMKAKNRKVVDGMKSRQQQVRQTIAKQLKAVEQPVDVFELLNEKLNKTSNMEEQRNEMKVMERSHNCSSAGLGIQALDLDKKMKELKDKERKLREGIARNQRDAATANTLKKNLIKCRDEMQHLLSRQQRLNDLMDSRRKKKDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9R8</accession>
    <name>A0A183H9R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4229</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003125">
        <property type="protein sequence ID" value="VDO39341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9R8"/>
    <dbReference type="STRING" id="387005.A0A183H9R8"/>
    <dbReference type="WBParaSite" id="OFLC_0000422901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000422901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000422901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000422901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="677" mass="76555" checksum="57E9B507DD9E323F" modified="2016-09-07" version="1">MNHNILNSDAAFTIGVAFVFFVIFDSEIEISTWPSMQEFIYIITTLFFDPKPEDKGSYYWIKMLLLILLLVFPEKADVTLLKQHKDENNHQKETMTSSNNDFIKKDTSGRGLSDKEFQLSAKNLVIGNQITRQQQVQIMKKSQSDAKTDFLGTTPITSPALSAKVKNISAKKISTIMKGEFLPIQQNQIPSKKFPPLVPEMKLQLDSEAESSNHTKDEFQTTLTQESLIVPESKSYAFVKESQTASPKKPKSVKKCQIIRPLKKSQMLQVKKFTDTSVLKSDIFPIQEFPIVSTEKLQILPSSELQTAHEEIPQRKPARNSQSRQDLLTFAKELQFSARELQLTYSKEDEDDTHPKIVPTVPKKKSQVIQMNKPQTTVIQQSQLPSSRKLETTLSKIVPIIPVKNEKRIEEFPADSMTDPMIGSAKEHRIIDLKDSKGSTMRKSKIGPDKEIQIASVKEPEAIFSKELEDYRVKKFKELQHLPVGKFQTISTDRPGITFASKIQLAPLKISTTVSTKESQHISNKETEEPQLVPKHELKTVPVEESHFLPAGESQIPAVSIRGIPHDKESQSVPASEIEPLVRESSDNELQASPLKESDTVTETETQISRTNKLINIPEQQFLPISDASINFEKKENAEVEISQDVFDEKKSDNIITWVAVGKTVVISQYEQTEKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAD6</accession>
    <name>A0A183HAD6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear cap-binding protein subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">80 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS4447</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003383">
        <property type="protein sequence ID" value="VDO40042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAD6"/>
    <dbReference type="STRING" id="387005.A0A183HAD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000444701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000444701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000444701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000041">
        <property type="entry name" value="Nuclear cap-binding protein subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="MIF4G" evidence="10">
        <location>
            <begin position="41"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO40042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000444701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39369" checksum="7712B17095D4468D" modified="2016-09-07" version="1">MIHLPLTDHDRRRRAGDEDNDWYNKRRRTVPEKTEAEVHLEFLISRIGEKSGSSMESNLENLVQSLETYLITDIDRIIDVIIECICYLPEEVTAYSTLAGLLNSKKQKFGFELLHQLLEVLHKKLVSSDFIHALHIVTFLADLVNCHVVSSSSLVEFYESFMESACEERIPQVRSDWFVYAVLHSLPWAGPELNDREKEPLDNLLEGVDKYMLERNTSHAKLLQVWSAMEHEQEEYLDSLWTQISKLRDDGWVERHISRYYVAFDGSLAGAVTHNLPSFAPPPHTSVMVYPLPTVIFRFFDYADCPDGGPVLPGAHSIERFLIEEELCSIIENNCNSRKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAF7</accession>
    <name>A0A183HAF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003405">
        <property type="protein sequence ID" value="VDO40092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAF7"/>
    <dbReference type="STRING" id="387005.A0A183HAF7"/>
    <dbReference type="WBParaSite" id="OFLC_0000446801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000446801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000446801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000446801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13724" checksum="5B3D251E8FFB108D" modified="2016-09-07" version="1">MKSQYSAGSTNMALRRRSRRLASQEREDFFTSSSIDVLGVGNDEQVFTKIESNDESKRIEEINIEKKLLKYVQKSFLMFSFIFCKYRKIQVIKIRQLLYEHDRDRVAQVWSQTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAH6</accession>
    <name>A0A183HAH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4488</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003424">
        <property type="protein sequence ID" value="VDO40139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAH6"/>
    <dbReference type="STRING" id="387005.A0A183HAH6"/>
    <dbReference type="WBParaSite" id="OFLC_0000448701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000448701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000448701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038751">
        <property type="entry name" value="INTS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057980">
        <property type="entry name" value="TPR_INTS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS8 TPR repeats" evidence="6">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000448701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28988" checksum="2B342CBA09ECEC87" modified="2016-09-07" version="1">MYYSKRRNDGSLVREQTKQLLTRTQFLEMLRLIKEYRTISFLISFLSKMFGAAVNVAKMRKESDGLSSGHDINKDIFVEHPDYWQSNFEKKGSDDELSFNLPFLTECLDTVFKNALTVNPINAFWLRSYADFCFACDKFADALVLYMEACVACSDSLMRPLPDNVVDDIMWLKVQRCLRMSGAETLSALICQLMRNPNEHYVPTASSLMETHGDTLDACTAYFPLISDINLAEFMSDVYEKLHLDKKEQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAS4</accession>
    <name>A0A183HAS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4586</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003551">
        <property type="protein sequence ID" value="VDO40417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAS4"/>
    <dbReference type="STRING" id="387005.A0A183HAS4"/>
    <dbReference type="WBParaSite" id="OFLC_0000458501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000458501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000458501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000458501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17392" checksum="01D615F0DC32F450" modified="2016-09-07" version="1">MDASEDNDISEMPSMEPTENMMETEMVMIKNEAETVEEEAVEMKVNPDIHTMENPAETNENKANIIETLGSSDNFSVGSQFEKDSFKRFEMLLKKTENFSHCLSAGDVESVDDSSSNSTKGRPRNHSEGDHRHRKTEKEEDEELINQVKKSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBG4</accession>
    <name>A0A183HBG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003863">
        <property type="protein sequence ID" value="VDO41180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBG4"/>
    <dbReference type="WBParaSite" id="OFLC_0000482501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000482501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000482501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000482501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37085" checksum="182E4C1BE0E7937F" modified="2016-09-07" version="1">MQEKPFSGLFVVPEDSEFFRTVFRTIHSQAFNGGEIVFTVRIIFKVNDFFGMLRRRERTPLTHIPENDSRSIALAQILDAQRDFKIMANDGEIKTSKYLLYLSTNYFHELITTNPSAVSAVLNFNREIIEKVLDFAYKGIYNMEVRLIDKVRKFLQCVRRIRPLKQTEIINHISIKLNETLLQNWKSISLDDAVKILDIAYEQQFANLLDSAMNLIVDQYFIDFRTKDHQIECLNLAEVKIYKILERKTSNFSRLRYNEHSEGEEGQLFQRLNRSEIADFLAPTNVMLASYRKRGSVTRILKYKTRMPSKRQFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBH8</accession>
    <name>A0A183HBH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003876">
        <property type="protein sequence ID" value="VDO41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000483901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000483901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000483901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000483901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8449" checksum="1BC4FBD24D42FB69" modified="2016-09-07" version="1">MTPRAGGMHVVMLGRVVSDSITNIDREYRSVMPVYGKMMVLWNSDNERSAVIFSPYMSSTNLCFIEYLFALFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBJ4</accession>
    <name>A0A183HBJ4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS4856</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003895">
        <property type="protein sequence ID" value="VDO41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBJ4"/>
    <dbReference type="STRING" id="387005.A0A183HBJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000485501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000485501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000485501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000485501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10738" checksum="ADA89ED7ACFE01B4" modified="2016-09-07" version="1">LRACRRVNDFALAVRFIESLKEKCVLRRWTHKWLLDKIKPTMDELGIPTLEEMNYDKPELFVPLPEWWWERKWYKEYGFDKHGYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBQ0</accession>
    <name>A0A183HBQ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS4914</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003977">
        <property type="protein sequence ID" value="VDO41423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBQ0"/>
    <dbReference type="STRING" id="387005.A0A183HBQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000491101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000491101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000491101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO41423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000491101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="29843" checksum="4F8C2DDB073AD607" modified="2016-09-07" version="1">MKHVCRACHVMPGTSEVPGVLSACLVSLEPEAHLRVFPSSFQHDDRFLKNSRYRTLTTPDDTSCTHILVFPTSPELNLDHQGGNGVAELEEDDFSNLLTEEIGEEFSELIGNGEDLMTNGTGPPQQSTNFRLGGNTGIPSDYADVSIENQPLATGYYISTAPASDLPEWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGKGTEACHHQLDSQATADVLRYVLEMYNALSWLNIDLISGERRSCLPIHIQALMWLCNAVNRFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC15</accession>
    <name>A0A183HC15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5027</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004118">
        <property type="protein sequence ID" value="VDO41814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC15"/>
    <dbReference type="STRING" id="387005.A0A183HC15"/>
    <dbReference type="WBParaSite" id="OFLC_0000502601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000502601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000502601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000502601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13233" checksum="BD9439F93FE4A683" modified="2016-09-07" version="1">MRRLIVNQEEEERTSVNEQGKERLKCRQNEVQPDLRMQRSYDYNRHAFQYNPADDYNLCLQIANKILHQLRMSSPNQSVAASFDVELRREQSYNTTDLLSYVSRKPKLIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC79</accession>
    <name>A0A183HC79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5091</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004199">
        <property type="protein sequence ID" value="VDO42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC79"/>
    <dbReference type="STRING" id="387005.A0A183HC79"/>
    <dbReference type="WBParaSite" id="OFLC_0000509001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000509001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000509001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000509001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20408" checksum="2D88F168562A8E6E" modified="2016-09-07" version="1">MNTSSQLAAGSALDSSSVQQLNTIKEDLKTHFITREGVYRQMTLSEYSRPNRVALNQGGNNVSNAPVRVSFLTIQPTASTSQQHQAIGNIMLNGNIPTLRNLALDTDLEHNLDETDSPAYSDSDIGNDRICFNVGRELYVFVYRGVQSAVDLNKPIDKRVYKGTYPTSHDFNQETATTTSCRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCB2</accession>
    <name>A0A183HCB2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5124</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01004240">
        <property type="protein sequence ID" value="VDO42131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCB2"/>
    <dbReference type="STRING" id="387005.A0A183HCB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000512301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000512301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000512301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="7">
        <location>
            <begin position="62"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000512301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40705" checksum="D1F87C5D1A650480" modified="2016-09-07" version="1">MILSGAKGTMVNSVQISCELGQIELEGHRPPMTIAGRTLPSFRSFDTSPRAGGFVDQRFLTGINPQELFFHTMAGREGLIDTAVKTSRSGYLQRCIVKHLEGLVAQYDSTVRDHDGSVVQFRYGEDGMDVCKSTFMNSKQFDFLADNMQVLRSHILPIDYDENDWDLKKCEKAYKKIKKWRRKYGVKNNGKIYTSGYVEFSKEYRGTPREKIQKMWFELTDEERYEYHSKAGKACPAAVDEKMNPNRSLGALPQKLLDDIDEYIHLKSNTGTDIALDTFRKSLYWKGMRCRVDPGENVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMTASNDIKTPSAENCKMSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCI5</accession>
    <name>A0A183HCI5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004335">
        <property type="protein sequence ID" value="VDO42344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCI5"/>
    <dbReference type="STRING" id="387005.A0A183HCI5"/>
    <dbReference type="WBParaSite" id="OFLC_0000519601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000519601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000519601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000519601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56065" checksum="B798055567073461" modified="2016-09-07" version="1">MSRFNVKENVIANLTYSVAPRCAENIHALCVFGRLSTTLRRFLQDSPAVFNRLIHTSANVVCVAFDGNQKGDEQNLAQFMHLVLSQFRSSYDAHLVMDAELKKLRQNDLGDDEMISLSENFWETAQAIIEDLVNEYIAEDGSTSSLVMQKSNTSTAEKVTLFRFDASACALTTQSGQTIKQLQSLICPSSPWNITALYPQLERFCNERETEANVKPCRLRSYLHSFIVNVFIDQFKCKLEALAEQALNEQDAWRVLMHYPNPKVLGSCWNVYSVCNQIGKLILAMDKYTERLSALWLLVIDEFSDSANNVYEKILSFGKPTSEGKDSMVFNVSHEDGYKEKRKISAAWAVDEDISRLLKSLPNWFMVSSYENASAPSMNTPSAVSPTSESESDVCNRNERESEILIGNLGTAKQLVRDELITDIEVIRSLACIHESLKWFCSSMRSLIEKLPESSRNAMRKCVVQLQRTDENGIVHQSVSNILVYNLLIAITLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD37</accession>
    <name>A0A183HD37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5399</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004617">
        <property type="protein sequence ID" value="VDO43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD37"/>
    <dbReference type="WBParaSite" id="OFLC_0000539801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000539801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000539801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000539801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24563" checksum="AB920C9B775CDFE7" modified="2016-09-07" version="1">MDSIFTSNQKAQIHTEKLRDVKSEVLCSVICDFHHPLGVQTDLTTQINFLPELLRSYFIEQDKEIEKKLGKSSIAKQTEKDENKKSDQRKYICKQWKVDPKILFIDKVKWDPPVIDEILRKLQKEGLRQMSRNGPELRNWVGKKRLTLIKNDEKKLLLFKIFDHRNSIPKVVQRYVMDHYDMFASKALFLIVKVAKEASVKSDPISIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD39</accession>
    <name>A0A183HD39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5401</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004622">
        <property type="protein sequence ID" value="VDO43022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD39"/>
    <dbReference type="STRING" id="387005.A0A183HD39"/>
    <dbReference type="WBParaSite" id="OFLC_0000540001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000540001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000540001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052460">
        <property type="entry name" value="ER_disulfide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="101"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="234"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000540001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40996" checksum="82A17065B010082C" modified="2016-09-07" version="1">METIHDIAQFATESHSSPLVTLTLETYTSAINSGDEWLIDYYAPWCPPCLRLLKELRRLHNYVENIKIGTFDCDQHGDICKKANINAYPNILWRSGDRYSARAGYLDVSAIAEFIEDARNPIVVSLSPSDFDSLVLDRKQGTVWLVDFYAPWCGPCNQLAPEYKKLARNMRMKEFIHFGMVDCDHHRHLCKNLGIQSYPTIRLYSSGFVPMDYPSNWWRDHRSMEVWLRNYLPSKVIIMGSDLFAKVLNDDEPWLIDFFVTWCSHCIEFAPVFEHIAEIFEGRVKFAKVDCGLWPNVCQNVGVTVYPTVRFYSGSRGNHIQIANGVHIESQNADTIIHQVENELTKIDLLYKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD44</accession>
    <name>A0A183HD44_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS5407</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004629">
        <property type="protein sequence ID" value="VDO43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD44"/>
    <dbReference type="STRING" id="387005.A0A183HD44"/>
    <dbReference type="WBParaSite" id="OFLC_0000540501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000540501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000540501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000540501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13852" checksum="28BC571199F3E421" modified="2016-09-07" version="1">MNSPRNVLKIHSKEDNCWKSTSTFGGHSGQVRDIAWDPTGSYLLSCSFDQTTRCYAPCANHGVIIEIARPQIHGYDLTSIASISSSRFVSGADEKILRVFAAPRNFVEMLGSISKYDCEKVIFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDB2</accession>
    <name>A0A183HDB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5473</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004718">
        <property type="protein sequence ID" value="VDO43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDB2"/>
    <dbReference type="STRING" id="387005.A0A183HDB2"/>
    <dbReference type="WBParaSite" id="OFLC_0000547301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000547301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000547301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000547301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40103" checksum="C4D1CF9492E869D1" modified="2016-09-07" version="1">EIFIDCYYITNNFSEIEETKGSVAGTSSFSLDITARGRPLIIFKGYEHRQVRVDQARNLKAYRCIKKKCKGRLHSDYNDTNVRIVSEHIHEPNFDAEFKRRRRTLLRELAQKGNVSPSQIIQKTRDLEMQYHVVCESTKTSYAAERRYIQRYWNRQKQQELSSQNGFLPEKYQIMDYNSELKMKQEDNKDIGEESDNRLSSFRPDSVQMSEQFNQFLQMISNGITNGNSASAMNVYLNLLLQQMLSNAVGNNSSNSVQEKDDYSSSDFSNQNQSSSLSTKQPLVDAQIQTNMEEDGFHPPTNGVAVCDILALELRTILAKKFWPKHYLCEDKLKLMIDAIYKLLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDC5</accession>
    <name>A0A183HDC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5488</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004744">
        <property type="protein sequence ID" value="VDO43322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDC5"/>
    <dbReference type="STRING" id="387005.A0A183HDC5"/>
    <dbReference type="WBParaSite" id="OFLC_0000548601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000548601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000548601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="244"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO43322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000548601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38339" checksum="835759B25CFE97DA" modified="2016-09-07" version="1">MRLSNNTRKQSSIVLIEILNVIVKTPRFLGNVDGIFYVGENMQGPYPVTIGELKVIGTDLGFNGMLSYSLVQGNNTLFRVVPQTGELQITESLDYEVQNQYELIVQATDLTLPRRSSRRSTVIVEVLNVNDNAPVFEQPQYYVEVMENEAIGENSTVLCLKVTDEDDREFSMIRYSLEDADLLPFFINSTTGCIERLEILDRESQSQWILKVTAHDNGKFVERSSTAIVRIRVLDENDNIPIILNEQLDVFIPNNVKEGNVVYVLSANDLDEDDFLYYNLSGPDVSYFQINQSGIIIAVRELIKQDYSITATVSDHGNLNSSVGLGFYISETMKFPIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE29</accession>
    <name>A0A183HE29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3668 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5743</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005102">
        <property type="protein sequence ID" value="VDO44172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE29"/>
    <dbReference type="WBParaSite" id="OFLC_0000574001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000574001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000574001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000574001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33245" checksum="8CE5E908B2FDEAB5" modified="2016-09-07" version="1">MVVTHTLDVRCSELSVLYNEGAFDDLATFFSDRSTMKQDEKCDLMLMDVITVIDFAIQCPQLKVELRSKRGNLLDQKTKSTTSTPFALADVKHLVVGISNKEQFVTMIEIEFGSLEVEDLFESTTDSLLCIRSQAFTKKKQMSASCPSLIVDDSVDDLRFVSASSQRRTRGLSLNSYPAAMGTNRNERSKSSQESASLKWYDIGIKNIAVAGASLFTLLLIDKEHPSFESIYKKVSCLVNVNIPKVEMCMNRRSYTLLLDFFGLLEPKMDFHEDCIEILAHPSAANTNIAVKNLGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEC2</accession>
    <name>A0A183HEC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RIBORED_LARGE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5834</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005234">
        <property type="protein sequence ID" value="VDO44501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEC2"/>
    <dbReference type="STRING" id="387005.A0A183HEC2"/>
    <dbReference type="WBParaSite" id="OFLC_0000583301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000583301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000583301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleotide reductase large subunit" evidence="3">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO44501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000583301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="53680" checksum="339671F536253DF7" modified="2016-09-07" version="1">MERVRDDKTWSLMCPAECPGLEDSWGKAFEELYIRYEEEGRYRKQIPARKLWKRIVFTQIETGMPYMVYKDTCNRKSNQQNLGTIKCSNLCTEVVLYSSREEIAVCNLASIALNRFVTSEKTFDFKKLREVTKVVVENLNKIIDRNYYPVPEAERSNNRHRPIGIGVQGLADAFILMRYPFTSAKARDLNKRIFETIYYAALEASCELAKEQGPYESYKDSPISKGILQFDMWNVTPTDQWDWVTLREKIAMYGIRNSVLLALMPTASTAQILDNNESIEPYTSNLYTRNVLSGTFQIFNKHLVNDLMDLDLWDDEMKLAIIKNKGSIQNIERIPQEIRDLYLTVWEMSQRDIIDMAADRGAFIDQSQSLNIFIANPNYSNISSMHFYGWQKGLKTGMYYLRTRPAVDAVQFTVDKICRKEYVSANNDFKSDLILDPTSVNELTTEMMECKISSESDFSMYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEE0</accession>
    <name>A0A183HEE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005262">
        <property type="protein sequence ID" value="VDO44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEE0"/>
    <dbReference type="STRING" id="387005.A0A183HEE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000585101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000585101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000585101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000585101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9060" checksum="ADB9394DB83D27A3" modified="2016-09-07" version="1">MIYKLMMNEIIEISASEIRSIFKVCLRTFADRKAMEQHESYHKRVHLLIEHGDLEIVDPEILLPETCDIMDEEVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEE6</accession>
    <name>A0A183HEE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005269">
        <property type="protein sequence ID" value="VDO44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000585701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000585701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000585701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000585701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10989" checksum="7D7772831336FB77" modified="2016-09-07" version="1">MSLENPEEAVSGALLMTEEYEVKVSRKDSLKDNLGNTDMEGTDNLLQWSDQCAQTFNKLQMTTHGHTSDLRRKKLLFLWRFLTLRGLFRLLGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEL8</accession>
    <name>A0A183HEL8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5928</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005370">
        <property type="protein sequence ID" value="VDO44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEL8"/>
    <dbReference type="STRING" id="387005.A0A183HEL8"/>
    <dbReference type="WBParaSite" id="OFLC_0000592901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000592901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000592901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552506" description="Large ribosomal subunit protein bL9m" evidence="6">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein L9" evidence="7">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000592901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14210" checksum="6A2A77D4559EA999" modified="2016-09-07" version="1">MAGTSLDSITSIPLVLLLLQFTWVLRRVFAPEPTQLGCMQRNPAEHPDLMKLEVVEIEDLKPVGPLKVILLKDVEGIGNQFDIVEVNRRLARTDLLLTRKAAYASPFNLQYYGEMKEVCFFLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEV5</accession>
    <name>A0A183HEV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6019</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005486">
        <property type="protein sequence ID" value="VDO45115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEV5"/>
    <dbReference type="STRING" id="387005.A0A183HEV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000601601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000601601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000601601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="2">
        <location>
            <begin position="133"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000601601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41211" checksum="02B341D59E30B19E" modified="2016-09-07" version="1">MRRLPPPPEYFQLPAIEKAAYLFYCILYRHHYLPVDLFHKKFNREYFNYMCKGDSAEIALWKICKHTQEEYIAKRSINQLKAYEMSQKQLFSDDHETLDSRQSERGSQVEDDSDQLSVDSAAKEPMKFRVPHSFLKFGVGGKAIILNVRNSENILEIRDLKSLFGNHKLQRISNVIESFRGPLVAGFTPTHSVLLYVQRQIELILKSEAYLLNPSSSLESDCLLIWQLLEMLVQQQGRVTGPDLSRLLMATCDVSEQRRHYKEKSRSFTPTNFNERSVDSKAYDRFTQLLLGGHIKEALDSAIKDGLYSDAMILARRMCVGEPHELEKIETAFLSHRSEMNPVMTLFSVANGQPAPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFM1</accession>
    <name>A0A183HFM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Active regulator of SIRT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6282</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005879">
        <property type="protein sequence ID" value="VDO46018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000628201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000628201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000628201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000628201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8822" checksum="EBD72A23BE6AE4FA" modified="2016-09-07" version="1">MIYETNCKLDPDKTKQLIGLMDERNRRRKKTLHGVLDRKRKFRKSSNKSIFTDEDFMKIGPDRIKVNNFKFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG81</accession>
    <name>A0A183HG81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006194">
        <property type="protein sequence ID" value="VDO46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG81"/>
    <dbReference type="WBParaSite" id="OFLC_0000649201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000649201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000649201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000649201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23436" checksum="6A9AA52DFD8E5051" modified="2016-09-07" version="1">MYSKPNINTSRAENEALIKDGLIFRLYFINGNGRMLISDLLDPTSPAAYVSGCDPQKQRIIIRQSPYVDPFNWGSYLWLSNMRAFGPIQSDNTVICSFRYFPAGQGSFMLGTYGQRNRTSIQTSRSFMGLTLNHDRTRFLDILSEKKKLFLTIFGAYDENNNILLEKTHDEFDLSIAMTIYDSTINYRVTGSVNTEDISCIRCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGL1</accession>
    <name>A0A183HGL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6624</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006407">
        <property type="protein sequence ID" value="VDO47198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGL1"/>
    <dbReference type="STRING" id="387005.A0A183HGL1"/>
    <dbReference type="WBParaSite" id="OFLC_0000662201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000662201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000662201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO47198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000662201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11873" checksum="14831F71F7805E41" modified="2016-09-07" version="1">MIDEAMLITILAHQTFSLAAITTFALIAIIQCTKKKDSTGAVPPGQPPPAPAPLPPMDEQKTQSLMDEGEGEKKKVEEKKEVGHFNSKSSISCSQLKSLDENLIQIYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHQ0</accession>
    <name>A0A183HHQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7016</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007053">
        <property type="protein sequence ID" value="VDO48887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHQ0"/>
    <dbReference type="STRING" id="387005.A0A183HHQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0000701101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000701101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000701101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO48887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000701101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32961" checksum="3614C91F6E06F3CB" modified="2016-09-07" version="1">MEVIIGNGNVALDCSRVILSSGTDRLLNTDIASSILDILSHSQIRHVTIVGRRGLLDVSFTIKEIREQITLPNCSFSVEIEDSDLLTMKETQETLSRPKKRIAELILKNSHLEKPKSDRHCQLLFRRTPTKVVTDNRGFVKAVQVTHSLSGRQENLPCGLLLYCIGFENVALDGVPVNANGEIKMLDTVRVATEEDSLVYAAGWCAHAPRGIIAHTQMNASNVADRLCSDLQKCGLKATQITGSHQRLLSRKVGYLTWNDWKKIDEEEKKLGVMHGKEREKLLNFENFISSKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI47</accession>
    <name>A0A183HI47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007289">
        <property type="protein sequence ID" value="VDO49618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI47"/>
    <dbReference type="STRING" id="387005.A0A183HI47"/>
    <dbReference type="WBParaSite" id="OFLC_0000715801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000715801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000715801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO49618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000715801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16025" checksum="5D6A860566BE4D29" modified="2016-09-07" version="1">MKEAIELRNPTDMYYAQPLEDNLFEWHFTVRGPKDTDFEGGIYHGRILLPIDYPMKPPSVIMLTPNGRFQLNQKICLSISGHHPESWQPSWSIRTALLALIGFMPTHAAGALGSLEYPPDERRKLAKRYRFFFLMFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ02</accession>
    <name>A0A183HJ02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007815">
        <property type="protein sequence ID" value="VDO51131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ02"/>
    <dbReference type="WBParaSite" id="OFLC_0000746301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000746301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000746301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO51131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000746301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10261" checksum="B9A082F398DDBE4C" modified="2016-09-07" version="1">MGRERATGVRVNDWEVLECRVGKRMINVRVCTVLQRQRNSSAATRFTPPARPTYHKSPHPPSHHVLAFRAAAAGRDGHSYIHPCSISSSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJN7</accession>
    <name>A0A183HJN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7702</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008213">
        <property type="protein sequence ID" value="VDO52238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJN7"/>
    <dbReference type="STRING" id="387005.A0A183HJN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000769801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000769801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000769801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO52238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000769801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10595" checksum="075506BF041FAB13" modified="2016-09-07" version="1">MFYSYSVFDVTKGSLFYGPEGAYNTLAGHDATRALAKMDLTLVKDTPDDVSDISDMDLDTAKEWMESFIYKYPVVGKLLAEGEESTDYNDELASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK86</accession>
    <name>A0A183HK86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CARD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7894</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008546">
        <property type="protein sequence ID" value="VDO53033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK86"/>
    <dbReference type="STRING" id="387005.A0A183HK86"/>
    <dbReference type="WBParaSite" id="OFLC_0000789701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000789701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000789701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO53033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000789701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10549" checksum="0A39BF7DEBD0C1EA" modified="2016-09-07" version="1">MSFKRKFIAINNMVFNNFREFLAQMGIGLRLEKLLASCKTKEEKKNLIKSCEILLSEADMGARFKVMSIFPKILENILSQRKGPAGFAGAKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKU7</accession>
    <name>A0A183HKU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endostatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8105</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008911">
        <property type="protein sequence ID" value="VDO54024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKU7"/>
    <dbReference type="STRING" id="387005.A0A183HKU7"/>
    <dbReference type="WBParaSite" id="OFLC_0000810801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000810801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000810801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO54024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000810801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11340" checksum="72C23CE68592FBBC" modified="2016-09-07" version="1">MHSGFPSHSLQAKDLVLHLIALNTPMSGNMRGVRGADLACYQQAREANFRTTFRAFLSSHVQDLNKVVHNGDRDTPVVNLRGERLFDSWSDIFEQKQIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM67</accession>
    <name>A0A183HM67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009830">
        <property type="protein sequence ID" value="VDO56354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM67"/>
    <dbReference type="WBParaSite" id="OFLC_0000857801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000857801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000857801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000857801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15638" checksum="E94B892E63C70274" modified="2016-09-07" version="1">MRRFWSRFADRSSNLEKTQMSPEFLDLTKKYDTYKECNDVLVERLEASIQQNQAVIAGGKIIDAPNENPFEKFSNSLFSLYSCIPSNKHSCIQSWISTTQNLAKVQREHQVNHFFFLPQSSFKMSLQIYSATFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNA2</accession>
    <name>A0A183HNA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA replication ATP-dependent helicase/nuclease DNA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS8967</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010568">
        <property type="protein sequence ID" value="VDO58201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNA2"/>
    <dbReference type="STRING" id="387005.A0A183HNA2"/>
    <dbReference type="WBParaSite" id="OFLC_0000896301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000896301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000896301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO58201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000896301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23332" checksum="CA09FE77A127E78A" modified="2016-09-07" version="1">MRPQIAITRSGFDVTENSLLDLWQKELYEQYAEQLFVLNLSSQEVEDELSLYFKTITRWVSSHMPKPKGRNEYLQMGSRIKEVVDIEESIWNSCYGFKAKIDCTLKINKKDGDEKLFPVELKTGKSNPNTEHVTQVMLYCLALASKQGTIESGLLLYLLDATVRTVSPKTIDLKGILHMRNEIAAGISAVSLDNLPGSFSLLNIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP63</accession>
    <name>A0A183HP63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9269</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011201">
        <property type="protein sequence ID" value="VDO59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP63"/>
    <dbReference type="STRING" id="387005.A0A183HP63"/>
    <dbReference type="WBParaSite" id="OFLC_0000927401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000927401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000927401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000927401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13311" checksum="D5BCD65ADDA2D0C4" modified="2016-09-07" version="1">MLEDTKRTLIALCSILTVLTVIIIFVLIRKSKSLTVKQQFCQNLPDRRECIFPEYYDSVIEFNTSSTCRRQNTFADLRQSKSFYDRIPTQIPVNAALIHDNALLGETDFTYLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPC5</accession>
    <name>A0A183HPC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9338</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011346">
        <property type="protein sequence ID" value="VDO59821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPC5"/>
    <dbReference type="STRING" id="387005.A0A183HPC5"/>
    <dbReference type="WBParaSite" id="OFLC_0000933601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000933601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000933601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000933601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29011" checksum="4CAF058C6C421BC3" modified="2016-09-07" version="1">MESIPHALVTTDTIPPDRVPVLIPQDNSSRYREMNLRNRKGDSSKNGVARKVGSEELKILERMGKYQTMMVDLSLLTCSHSDCKEKQPFSSLFTFAYHLTVKHNRRDISNKRIPCYLCDFESQTYTALIEHLKSVHEQYYQEHVTARSTSEELKRGRKGKQAKIILMRGRSLSPLSDDFLETEESSDGSEEIGYDSAPVLESMANMETENIDLIVKDRMDYIIALVCGDVEKAPVLEDSKYELNTQVLLNILNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPF8</accession>
    <name>A0A183HPF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CARDB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011419">
        <property type="protein sequence ID" value="VDO60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPF8"/>
    <dbReference type="STRING" id="387005.A0A183HPF8"/>
    <dbReference type="WBParaSite" id="OFLC_0000936901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000936901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000936901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000936901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22285" checksum="1380FA3330177003" modified="2016-09-07" version="1">MPPKTPNGRITKYYVTVRGQLRHVSPGGILSNDDFPTEEKNQCVNYNNNDSSYTSADAIADFYSCRFGPFDQQIILKNLFALPNRNYTSFVWAENSAGRSENATFSEQCITDFAQPDAIDAPASLSQNGTIFSLTFNNEPDEVNGPVACYYVAIVPLAPDVVIESLPAPDSVIVDTFMKTMSNNLQSEQPKQVIFLFFIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPV6</accession>
    <name>A0A183HPV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endopeptidase S2P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011739">
        <property type="protein sequence ID" value="VDO61134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPV6"/>
    <dbReference type="STRING" id="387005.A0A183HPV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000951701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000951701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000951701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO61134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000951701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17743" checksum="7E508AEFF629615E" modified="2016-09-07" version="1">LKNEISNCWSIFRRKCAHVCQQGLQSCSSTENCVVTNQTLSNLHSSCVFPALLNNMSFMRISMGNASRIVLYVGYVKELKFDVQVSNYVPRLPISLTLLPYCIELVAKYLFTFSFAFAVINAIPCIYLDGQYICSNFVDFMFSKLRPRFLNMDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPY8</accession>
    <name>A0A183HPY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011832">
        <property type="protein sequence ID" value="VDO61391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPY8"/>
    <dbReference type="STRING" id="387005.A0A183HPY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000954901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000954901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000954901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000954901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10332" checksum="E8DEF6D5B01F35F9" modified="2016-09-07" version="1">MIASIVAKEQALLKMNTAAAASSTAEHGRLTGFAIPNRAHTQVIVNGARENMSSPSEMSPTSCSPSSSDTLQSTQGGTSTTIHAHNEHTGPEDTAPKSGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQD1</accession>
    <name>A0A183HQD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAS_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9694</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012168">
        <property type="protein sequence ID" value="VDO62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQD1"/>
    <dbReference type="STRING" id="387005.A0A183HQD1"/>
    <dbReference type="WBParaSite" id="OFLC_0000969201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000969201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000969201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS fold-3" evidence="6">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO62538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000969201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13473" checksum="D568921B3D8BE702" modified="2016-09-07" version="1">MLTRSGITELKLSPSTFMFRARLDLNIIFVDSRVTALTGFGASSLLDTSLYQMVLLEDAHIIEKAHKILLQKNQSITGYYRLLHRLRGYVWAQSQFCIVPMLRAAITHCIVAITEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRJ7</accession>
    <name>A0A183HRJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAP1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10109</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013140">
        <property type="protein sequence ID" value="VDO65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRJ7"/>
    <dbReference type="STRING" id="387005.A0A183HRJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001010801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001010801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001010801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001010801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13749" checksum="BE502ACB452D9613" modified="2016-09-07" version="1">MAKQEILNEKQRMLSEAWNQLNGCVELNVYLQEELTRKDVAYHNLEQRLASAEERCSTISQHFSISNSTLDNVSSGALPHEFHPLPEVQDENDLLSSSSVNGDPYMLKVEPQFGRLITTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS35</accession>
    <name>A0A183HS35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10291</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013552">
        <property type="protein sequence ID" value="VDO67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS35"/>
    <dbReference type="STRING" id="387005.A0A183HS35"/>
    <dbReference type="WBParaSite" id="OFLC_0001029601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001029601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001029601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001029601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15698" checksum="F618020A71723D28" modified="2016-09-07" version="1">MEDYRRQASTDKARASEAVQKAQLAEKAAEGANKTISEAQDSLRNIINQLNSLDGVNSEELDELEKQLNQAEELLNSADLDKQVSLLKEQKIEQDRTITQFKNEIDTLKDEVQNLEEIRDSLPNKCFNVINLEQEGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSP3</accession>
    <name>A0A183HSP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10499</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014051">
        <property type="protein sequence ID" value="VDO68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSP3"/>
    <dbReference type="WBParaSite" id="OFLC_0001050401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001050401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001050401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001050401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10588" checksum="5DF59CFD49CF825D" modified="2016-09-07" version="1">MSKLCEGCDIDVDIWPLRECRGEDINHWKGHLWLCEKKVDPQSLYHIEGSACSPVQGTFCLIIPSNLHFMCSYCFRCFLTHLSLHRVPPQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSZ9</accession>
    <name>A0A183HSZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy-related protein 101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10612</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014343">
        <property type="protein sequence ID" value="VDO69921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSZ9"/>
    <dbReference type="STRING" id="387005.A0A183HSZ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001061101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001061101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001061101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO69921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001061101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12358" checksum="D69DA6AF9590E48B" modified="2016-09-07" version="1">MILQSSFSSTFRPSSSDEWAASRAPATDPTPEWKRKLEEAAEAVNRQVAASINSDCASHEGILLRNESKRKQKLSWLWEDLPKFVKEHVKIFYGQPMIVAYAEFCILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT40</accession>
    <name>A0A183HT40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SMC_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS10647</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014414">
        <property type="protein sequence ID" value="VDO70231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT40"/>
    <dbReference type="STRING" id="387005.A0A183HT40"/>
    <dbReference type="WBParaSite" id="OFLC_0001065201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001065201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001065201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="5">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO70231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001065201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23145" checksum="9C5846860CE2F407" modified="2016-09-07" version="1">SGEITVETDKDGIVRYKNIPEYSDEEIKNFNLQDMKFTLANLEKRKAGKVLNTNGLLEYVTKLERYDREVEALTDISTKRDKHRQFCEQLKKQRMNEFMDGFTRIGLALKEMYQMITLGGDASLDLVDSLDPFSEGVSFGVRPPKKSWKQITNLSGGEKTLSSLALVFALHHYRPTPLYVMDEIDAALDFRNVSIIGHYIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU94</accession>
    <name>A0A183HU94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015469">
        <property type="protein sequence ID" value="VDO73458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU94"/>
    <dbReference type="WBParaSite" id="OFLC_0001105601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001105601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001105601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001105601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6909" checksum="948B285D591FE07B" modified="2016-09-07" version="1">MLIENLGFLGGFVDVLVTGFSHQSSSVFFKFLIRGVALTLRISIIFLIGHFLIFTVLDIECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUL4</accession>
    <name>A0A183HUL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitellogenin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015794">
        <property type="protein sequence ID" value="VDO74398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUL4"/>
    <dbReference type="STRING" id="387005.A0A183HUL4"/>
    <dbReference type="WBParaSite" id="OFLC_0001117601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001117601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001117601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001117601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14142" checksum="551567456F4D4D5B" modified="2016-09-07" version="1">MTSKAAGGPLIRHSPETKWYDYGDLECAEQQTSDLDYLNSIEEQAEILLKKDCELQMQMQSKKKMIETAWLSSVLTRGTANDKVTAMQILTQQNPVHSLAYVASLVNIVAKKNTREAFSLLGQLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV03</accession>
    <name>A0A183HV03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Telo_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11317</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016206">
        <property type="protein sequence ID" value="VDO75564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV03"/>
    <dbReference type="STRING" id="387005.A0A183HV03"/>
    <dbReference type="WBParaSite" id="OFLC_0001131501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001131501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001131501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001131501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17134" checksum="21ECF2832EA67DEE" modified="2016-09-07" version="1">MIIILCKLRSNLDYIYIKQGNYLLQVNIYAYVSNVKIRSQSVETLENGGIKTELELRDDSTDTYTTCIIYSNSLEAFSDQIQSAQIIRMHRARIKKTINEKLFLYGKLKTAGFAVLLFSGRLGDGFNPVYRSSAKFTISPDYKERVGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVI4</accession>
    <name>A0A183HVI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyhomeotic-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11499</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016660">
        <property type="protein sequence ID" value="VDO76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVI4"/>
    <dbReference type="STRING" id="387005.A0A183HVI4"/>
    <dbReference type="WBParaSite" id="OFLC_0001149601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001149601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001149601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001149601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23304" checksum="8DEEFACE7C35F26D" modified="2016-09-07" version="1">MGNGAMPQSTQTRLVTAAAPTSVRTSATGMLPNSFMPTSVMRQMTKNNNTPVIMEEKLRHSNMSICSTQYNAIKQNLVPEHFNVPHKLPGDAMVGGMASKNAANLMTRLALQQQYAQVLAAMQNGLSLNNWQSNAQMTTSVRAQALAAQAEHQRQYALAMMRGDLNQAQVIRARFLSQQAATFAALPSVPVASHSHHVCPLFFFENFLFIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVN4</accession>
    <name>A0A183HVN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elf-1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016776">
        <property type="protein sequence ID" value="VDO77238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVN4"/>
    <dbReference type="STRING" id="387005.A0A183HVN4"/>
    <dbReference type="WBParaSite" id="OFLC_0001154601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001154601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001154601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001154601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12596" checksum="50F73DF115DB696E" modified="2016-09-07" version="1">YPEQQPLAEISTIVCDVINVTQAEDVCNFSLAQPDEACSITKNETSEESYPNRLQSVEMIDRPSSQLSAHSEQNPWSTRKRKNKKRKKNSRNENLGEPLCGFKILPSLETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW08</accession>
    <name>A0A183HW08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017150">
        <property type="protein sequence ID" value="VDO78309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW08"/>
    <dbReference type="STRING" id="387005.A0A183HW08"/>
    <dbReference type="WBParaSite" id="OFLC_0001167001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001167001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001167001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001167001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22687" checksum="67E1A23D559E00F5" modified="2016-09-07" version="1">MAKQNDDIISPRFQNGILASALADLQKYDSVTFHYDENNGTNSISEFKLNSILTDAANKAKNQRTSRLTSDYNSPLSTYRGIIGTALRNEDSPAENGYIPSQYEWQSLASIESSFKILPSEKSLSKKPILSNGRKSLTNSLDHSLSANSSALQSPRYTERHKGNKMGMISKWLQEISESTPDLNNRKEITDALVSPRTGILGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW44</accession>
    <name>A0A183HW44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3381 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11705</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017255">
        <property type="protein sequence ID" value="VDO78563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW44"/>
    <dbReference type="STRING" id="387005.A0A183HW44"/>
    <dbReference type="WBParaSite" id="OFLC_0001170601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001170601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001170601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3381" evidence="3">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO78563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001170601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19248" checksum="D279275A18EDE99A" modified="2016-09-07" version="1">MDEVTTDEVKCCLEDIKVCGPRELRLILKWRRSIIKKINEETAQNEAENATKDTVALINPEDERMAEIEQQLLTAKAEEKAALKKKKRKLLKDKANHEKRKKLKMLIEGDTYEVPDEQELFSLKKLAKAKDRQNTITNEVSELVNDKNESNSDNEKDSSSNDDNSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX59</accession>
    <name>A0A183HX59_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12069</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01018247">
        <property type="protein sequence ID" value="VDO81616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX59"/>
    <dbReference type="STRING" id="387005.A0A183HX59"/>
    <dbReference type="WBParaSite" id="OFLC_0001207101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001207101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001207101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO81616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001207101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14169" checksum="31E0FCA112E3E14E" modified="2016-09-07" version="1">MKVARFLPGMMFDENDATEELSSRLSLPIDFHQLHSSGITFTNEPFFRSLLLAVHRYNIKLHLSKSKIFLPGSMGRTMYGVIDDTGLLQYGQVFLQYSPSVRYVSGKKIVYTGKILYFYNNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXT8</accession>
    <name>A0A183HXT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12298</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018926">
        <property type="protein sequence ID" value="VDO83647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXT8"/>
    <dbReference type="WBParaSite" id="OFLC_0001230101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001230101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001230101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001230101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10342" checksum="5817478BF8630B8F" modified="2016-09-07" version="1">MRINSVFGLIFHQVDMNLCLLWMDIGQQVKIMQLVGMSMERTIIGEMLIKRKKKHFSSSCLSDLCRCIFSTPIFNEFFPAQTKKDFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYH8</accession>
    <name>A0A183HYH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039863">
        <property type="protein sequence ID" value="VDP11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYH8"/>
    <dbReference type="STRING" id="387005.A0A183HYH8"/>
    <dbReference type="WBParaSite" id="OFLC_0001254101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001254101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001254101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001254101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19309" checksum="D65556D5E9A03C37" modified="2016-09-07" version="1">MLLLLIRSDRCFQLFAQQWTALSKFYVLFGALTRKDQCLEEDTKQKLRSPSIIRFVEGYCYEMPLYPTLEDLLIDQYQHQKNYSSICNCSYQIPVYVVMNQGFIIAGEYRLFGETSLGNDGADDPQSYACTAAIMKAVQYGNYSGNDSPPVRSHAEPSAPLYESNSSTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZJ2</accession>
    <name>A0A183HZJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12904</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039970">
        <property type="protein sequence ID" value="VDP12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0001290501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001290501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001290501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001290501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56415" checksum="D8B0D7D530B99FC4" modified="2016-09-07" version="1">MASSEDLAWGVRKSSCEVFVDVANNCSMETKEHKLAPRFITLLHDTSRWVTHVAFQQLGRFIATFADANRINLEIRDGRLVVANSDMTEDGKSIQSNNRNNGMVIEDDENELYCQLPPGVVFPESNAGFESKESSASSSPQDQSYVLNELTCLLDSWDSWAMSDDSILNNSFVLNSMDLDVGNGVSASCSTHSDLTKLRLFPSDXXXXEPSQMDDSDDMSAYSPLIYWSAGSFDIDLKSYGKSTINHNSNNIKKDRNNVKQLIAEFIQRHSNLFYDASKYRMNDAQTVTDEHSKYDTYVMEEDDLDAPDEISDKMNKTFIVLSETGQSADSIDDQNEQTTSSTISIRTQMVIPQALLDSFVRMVSPCDNTDGEINRQCAHSFPAVAFTLGRSNWPCIVGTYKQLASDMQWRVRHTLASSIHEIAAIIGEENADVHLVPVFERFMEDVEDVKLGLLNHLYDFFKLVTPSTRQKLLSQLPNFLHSDADNGRNWRYRYEYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZQ2</accession>
    <name>A0A183HZQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS12964</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039993">
        <property type="protein sequence ID" value="VDP12601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZQ2"/>
    <dbReference type="STRING" id="387005.A0A183HZQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0001296501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001296501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001296501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDP12601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001296501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26596" checksum="EE2BBF5C457EA104" modified="2016-09-07" version="1">MAAKVFSLTITSNLRQYPYEKRYPASMTLHELKEKLQLVVGSSAECMRTELHDKDGKFISSLTDDQATLEKLGIFFRFLIIFSGMKIHVSDTSVENPVSYENVATVGKYTISEEKYDEREDSVRAWKRREGLKIQYDALAGTENEAKQFKVGDRCTVHASNQQEKRGVISYIGRTKFKDGYWIGVAYDEPFGKHDGSVDGERYFTCENKHGVFVRPREVKKCEQDEEMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZV2</accession>
    <name>A0A183HZV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13014</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040012">
        <property type="protein sequence ID" value="VDP12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZV2"/>
    <dbReference type="STRING" id="387005.A0A183HZV2"/>
    <dbReference type="WBParaSite" id="OFLC_0001301501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001301501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001301501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="194"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001301501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56196" checksum="2F721AA3A67AD021" modified="2016-09-07" version="1">MNLFLATSIFKTDWTKCKGFFKRTVQNKRVYTCVSGTGSCPMTKEQRNRCQFCRFQKCLQQGMVLEAVREDRMPGGRNGSAIYNLYKLKYKKTRRLQALCESILRENAPRCGTLLGVSGATSRSTPPEQRRMGRTPPQSPPLGASTPNVQPSIEPLNLSAKESVIKSEEITPTTGCSSRIAVEYALSRSPFPTRNKNLIQELIEIDHIEKLINLKGLRIAQQLGSRISDSTIPACQRLSRIGDEIVEQLVEWTKMLPFYHELPVEVHTHLLTQRWAELVLLSACFYAASTRASNQDNLPVSSTTTEDSEEVSFFDSSVNLQLLQKRLCAVMGKHIPMEHVNKEASPLVEKFTALLHSFSRLKITLEAYVCLKAITLLHYTPHNCDETAIDMKESMVRNVYIRKVSIIQDQFVKALQIHLSQHENGARLTDILTWLPMLHSASSVLLHSKMFYVPFLICKNPQRIDGGAEVRVILSPLSYRPSATVTDYEEELNATSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0L7</accession>
    <name>A0A183I0L7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="10">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS13279</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01040122">
        <property type="protein sequence ID" value="VDP13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0L7"/>
    <dbReference type="STRING" id="387005.A0A183I0L7"/>
    <dbReference type="WBParaSite" id="OFLC_0001328001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001328001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001328001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="328"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="602"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="966"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001328001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131372" checksum="E7D1E27B001AF27F" modified="2016-09-07" version="1">MNISVELSSLCCTLPQNQQSEIMDYLARILCNTDEMQVFDYSLNSTIPHMTNCTQSSFLVLIPLIFLIVFSPLVLYDLKKSRHPPLELYSPTVARIIFCFLLVVNRLTATTINLITWLRIPSAYQPYSITSSCWQTITYCICLLLLIAYRNRGLITSGVLFNFWLLAAICAFPELRRRTAHAEDFTGTQDEHQLSVKYVLYIIYYAFILFEVFLSCFADKPKYWVKDEKLCPEDNCSFLNKITFSWFHSLAARGFRRPLEVSDLWRLRLHEESKNLVKKFKRHWVPAVNAYYEKKRAAERSNSPKKLGPKAEPSLLWALAKTYRWTILAGAAMKFVFDLLIFVSPQLLSALISYIEDLKRPLWMGIVISFAMFIVALIQSMILHQYFHKMFMLGINVRSVLTNAVYVKALMLSNTARKNRTVGEIVNLMSVDIQRFQDIASFIMLFWSAPFQGRQMKLRDERLKLMSEILNGIRIIKFYAWEKSMQKLVLEIREKEIAVLREIALYNAAISLTWSCTPFLVAIVTFGLYVKINPQHNQLTPQVTFVGLSLFNLIRFPMTVFPLIFTQGTQCSVSNTRLKSFLSDDEVRPSITDRSSSNDYALSIQNGNFSWNNNKITLANINLTVKKGELVAIVGKVGSGKSSLLSAILGEMDKLGGSVDVIGSISYAPQQPWIQNLSLMDNILFGKPFNSERYETVLDACALKPDLATLPGGDQTEIGEKGINLSGGQKHRVSLARAVYANSNIVLLDDPLSAVDAHVGRHTFNPSQTGLLAKKTRILVTHGLHYLKYCDRIVVIDDGKITEVGTFQELVQAQGHFAEFLEEFLMDKVRQPAEMEELLKDLQVLNLEQRKRLESLSITRQLAYSTSTTASHAEQTSLQDNISVEQQDSAIEHDIAMKRFSNNSIKSESYGKVGGVALSSQTANKIAVPSNDERSKLIEKEGVEVGKVKFAVYLLYLHAIGYGTTAVFIAIYIFSSVLGVSSNLWLANWSDGVKKTNITEVGEDDTNWRLAIYAALGLGQAAMVCTGSITMAYGMVFASRKMHEGILRNILHLPMTFFDITPLGRIVNRFEKDRVTMDSKIPACIKIFDDCEEFVAALIIIIFTYPQSFWVFITCVFFNFFIVDIEIVDTLLPHSSYSFISSVLLVLMTVAVILYATPMCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I318</accession>
    <name>A0A183I318_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040614">
        <property type="protein sequence ID" value="VDP15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I318"/>
    <dbReference type="WBParaSite" id="OFLC_0001413801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001413801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001413801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001413801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="16783" checksum="92AA3C276371F278" modified="2016-09-07" version="1">MGLLEGYQYTSGNSRFSTRQATFTGAIMKLALGSAAAMGAVIFYRLAGTFSLAEDATTSNVLDYAQSGSITGTYCQQFQYSVTLIWMIIGTVALFNAARSAYRKSNGEMVPWSTPVYYLIGGIMCYFVNGITAMIANTIGLEVGLDNMCKAFGMAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I325</accession>
    <name>A0A183I325_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14137</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040618">
        <property type="protein sequence ID" value="VDP15616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I325"/>
    <dbReference type="WBParaSite" id="OFLC_0001414501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001414501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001414501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001414501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13137" checksum="3DFFCDE6742B4E65" modified="2016-09-07" version="1">MAEGKGDERETSSFENRFWMIFQSKPKLSLCAKEEKASLLGPWVVVCMSSLFVPLLACHKEIPKRGAYSVSMQVDNDCKPWLAVSMSKKHIPLDHVSFRLFHEKFFFFFLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3P8</accession>
    <name>A0A183I3P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040792">
        <property type="protein sequence ID" value="VDP16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3P8"/>
    <dbReference type="WBParaSite" id="OFLC_0001436801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001436801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001436801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001436801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4137" checksum="67DD1B3C11FB90B4" modified="2016-09-07" version="1">MWEHSKAILAQNIDDEENLKQSRRAFKEISKLCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4P6</accession>
    <name>A0A183I4P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14708</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041111">
        <property type="protein sequence ID" value="VDP18347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4P6"/>
    <dbReference type="STRING" id="387005.A0A183I4P6"/>
    <dbReference type="WBParaSite" id="OFLC_0001471901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001471901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001471901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001471901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28781" checksum="A1C0A524EA5CD3E8" modified="2016-09-07" version="1">MEMGVEHEHHMPHHHESRRTVGKINDELRFSIIDAVYLRPAIWDHGRELRNLGQRKDHFIEIAALLSTDENLLSCHDIEKQWKNLKDSYFKLRKKVKIDASGKLIQPRWKYFSAMMFLDRLSNNNASFSGANTSVYDEINDAALVRQESFLGKRNADGNLTPIGSSRNVIDGRCKMKKAMISTSNTVDGELGESTVLATEDEYSAFCNSLIYPLRDIGSMNRLECIKLQKVIRDVIHEKQMELLENESVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5L6</accession>
    <name>A0A183I5L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15028</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041506">
        <property type="protein sequence ID" value="VDP20064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5L6"/>
    <dbReference type="WBParaSite" id="OFLC_0001503901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001503901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001503901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001503901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4373" checksum="85011085E00CEB0E" modified="2016-09-07" version="1">MRSFICCCIFSSKIIASKTTEQYHTKCIFNSEYSSIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Z1</accession>
    <name>A0A183I6Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042260">
        <property type="protein sequence ID" value="VDP22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Z1"/>
    <dbReference type="STRING" id="387005.A0A183I6Z1"/>
    <dbReference type="WBParaSite" id="OFLC_0001551401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001551401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001551401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001551401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17379" checksum="1725BDD500711E7F" modified="2016-09-07" version="1">MNDSLEKAAFGRKHLRRRSSLFFKNAEIDNVITDDLSEVDCCNNSNEKRLEEQVVTAGRKQRRASMQITYEPPPLTLKPILMSAVQKTARRLTMKAKGWNKYKRVHFHSTPNVYDISPRSGKIPGVVKMPDSPPIIKESVISEVRFSFFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UAU0</accession>
    <name>A0A3P7UAU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001119">
        <property type="protein sequence ID" value="VDO31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="69" mass="7816" checksum="02EFB8A5C6177D14" modified="2026-01-28" version="1">MKREFPDSGFYTQDPVETVTVLNLAGNAANPVVKPFQEPLFRTDTAKEIREKVSEGDVGDEDSEMRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UD33</accession>
    <name>A0A3P7UD33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000679">
        <property type="protein sequence ID" value="VDO29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1T0"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="493" mass="54394" checksum="4A17B1CA32400218" modified="2026-01-28" version="1">MVRSSRIFEVVFGRKLRRVHDGTTMGYSEASVHHAVIVIFLEYFAWGLLTVPVINALANTFPTNKFLMNGLILGIKGLLSFLSAPLLGAMSDKWGRKSFLLLTVFFTCLPIPCLKISPWWYFALFSISGLFSITFSVVLAYVADITDKADRSTAYGLISATFAASLITSPALGAWISESWGDDSVVLLATAIASFDVLFILLIVPESLPCRNGRIVDAIRWQTADPFATLRIVWEDRLVLHLAAIIFLSYLPEAGQFSCFFVYLKLVVGFTPEAVAIFIGLVGILSVFAQTGILFLLTSTVGTKYTITLGLSFQFAQLLWYGLGTKYWMMWAAGLLVAMSQLIYPSISAFVSVHSDCDKQGTVQGVITGVRGLCQGLGPALFGFIFYLFNMDLNMDSEGMGHVGIPPFPAPRIRIQPIISSRRNVTSVEKLEFNWKLIPGPPFFFGSLMVLVALFVNSSLPKVPSVNTRFFRRPSTTRSRQSSEDASHLLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V0D5</accession>
    <name>A0A3P7V0D5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000447">
        <property type="protein sequence ID" value="VDO28027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V0D5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="398" mass="42979" checksum="00F16BE19883494F" modified="2019-02-13" version="1">MLSSLLDNNRGNFGDWRNGSDSSKRRNSCDEDGRDSYHHREVNSFQFPDEEISRDGGDSPELGIREHTPEVIGREIEDDEEFGDFALARNLQSQYQNISTPSLVATQSRPIHKPYPLHTTDVPIPAVVPPPPPSAGSNVITPTTFFLDLLGLDEFNGNGNSGYSSTSFFKETSGTFTLQPPSLLKTVNQLASTRQPILPLHYDNLSPESISNTALSNANQQCISAAASSVAFADSITLPAAAAPAQATFPSVLSGNATLFSGSDDVSTTHVTLPDTTVQSPRHNTVLLAAATPLMPMPTHSVSVIPSHVNVPSPQVEQVSKSVLKIPSTWADASSKVNINLDDLGMKKKPQKHSVPMNQMTTLMSVPTADKDLFTKSIVFTSAPQQRVSSDDMLDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VBX0</accession>
    <name>A0A3P7VBX0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase family 2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001272">
        <property type="protein sequence ID" value="VDO32457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7VBX0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="2">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="154" mass="18178" checksum="7D817835C67C7D78" modified="2019-02-13" version="1">MILDKKFQADQLDLICINRYFGWYIDNGYLDTVNHSWIYEMDNWKLKYNKPIIVSEYGAEALPGLNQEPGRAFSEQYQQELLEQTHHAFDVLQKNHIITGEMIWNLADFMTADGVTRAVGNHKGVLTRTRQPKMAAYILKKRYKNLEKEMKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VPU0</accession>
    <name>A0A3P7VPU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005461">
        <property type="protein sequence ID" value="VDO45079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HET7"/>
    <dbReference type="OrthoDB" id="5798599at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="68" mass="7320" checksum="3EC600DC7A21FF5F" modified="2026-01-28" version="1">MSSNQPDCLTSLVSYVPDLNFGLNLPSTGVVNQFGISATNQIQQSVPLLPEQLIPLESISARIDCNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X7A4</accession>
    <name>A0A3P7X7A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000088">
        <property type="protein sequence ID" value="VDO25312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5827570at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO25312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="142" mass="16606" checksum="FCEC93A200490B70" modified="2026-01-28" version="1">MGCNRSRIYHENEVGIDHKDLALTTFEMQKADIVHDLDTDNDQTGRVTVDCIFRPTREIYGQRASDMAEQLIMWSRYGIIFRKRPFPHDFPAFAHEKPQVELAHLSRLHYSTALQKSKENSELKKKRTINENESIEDVTSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XCQ3</accession>
    <name>A0A3P7XCQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000397">
        <property type="protein sequence ID" value="VDO27718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XCQ3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="8">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="9">
        <location>
            <begin position="270"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="7">
        <location>
            <begin position="415"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO27718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="675" mass="78720" checksum="F09A6A4212ACCB10" modified="2019-02-13" version="1">MQRLRIADTEDKLRKLQRELILREDFQSVAYSELLWNEALDDFSHSIIAQSELICFILMLIVHLSKSSLITFPLPLMVFFWGVLAIPRPSKSFWLVTAFYIQFIIVFRLLFCNELVQTLIYSEKEISDNNPFSVQRLLAIDPNINGSFWDIALLAMVFFHRYKLLRLGMCRVDFQVRERHLSFSDDLMQEEGDEKMLDEVQFLNFCLLNEYFVLSKISKSTSCEKFCEALLMKKIPSSMDWYPWMVGCDISCLILISFFYLILGHGGSGNIYLNIPFLFELRTAMDWTFTSTALTMADFTRMENYYNEIEAQHCWILFDHWTNNYFPTRKGQPTPTSGKFFKGVLSIIALIIIILAPILLFAFLNSFGTRAPPKSIHFVASIEGYPALYSTDTVFNDETMSHLSKHNMQTLINELTNLEESDIKRNALSFISDYTYQDVFLINLTHHSLRNWDISLPGKKQLMNELHSSKTMRIVFEMSLLRTVDSKQRSHNFILATALTSMQSKIFLNLINGSITTARMSFPFAQFLFAPPNGYLLPVNVINLALKRIHSVSTWQYHGDYWSVTWDQKFVIFVDRVIPSWITIIVGSGGMIAMYIAVILVVGRFVREIVRTPIHKAVIQNIPNCENLLRLFHDIYVVREKRKFYLESRLYGKLVFLMRSPETLIRWCRYRPLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YP83</accession>
    <name>A0A3P7YP83_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013326">
        <property type="protein sequence ID" value="VDO66583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YP83"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="140" mass="15954" checksum="8EF62C76DD796C20" modified="2019-02-13" version="1">MHSGENDHFAQWHLVSDKIEDEAAIARHLTPQGIYQFRVIAKNEFGWGAPSLTSRIIQTHPKGSPKLQIEQLQSQCRVCVVTKPPKTRLISKSKNLGEITEEDEERDEAEEITPKAEFQGLTLITSEDPEKRFQVIILFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Z8K8</accession>
    <name>A0A3P7Z8K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005635">
        <property type="protein sequence ID" value="VDO45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Z8K8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="327" mass="37747" checksum="A54DE3C319AEF54B" modified="2019-02-13" version="1">MQKEEILCKTKRLSTSIETINEQSRRFSVTSKSSISSRQSRLSILSVSEEISADQIKRLEEFEKTINLLMNSLDVGFIWNFLERKLKILIQQKQKEQQNGATDPHLLTNEVKMLKEEEERRMTQELTNFPQIVLFCLNTIELDSHGDIRERYLPQLLSSILTTLAEKDVASIDGQLLVRLLIVAKAILNEINQSAVVMEAGIVTRKRGEVYEIVRCEEFDSMEKPSTESGAIKEQWRVENCLSSCQRLLSQICDWYCKERDTERLQAFYAISILTREFADFPLYDLNMQEINGHCKQHVSSNYPVWLSALLNILSIDEWDASVNSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BCT3</accession>
    <name>A0A3P8BCT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040520">
        <property type="protein sequence ID" value="VDP15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="95" mass="10485" checksum="B205337BD616C8AA" modified="2026-01-28" version="1">MPFRTSSIFCKKSAELLGYLSQAVFGLHSSLSLTVTPTVLIPTAKNIPEAINATILTHTVPHISRSKSYVKSKRRPKFHSGIDRGCGCQRRSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BPJ1</accession>
    <name>A0A3P8BPJ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015629">
        <property type="protein sequence ID" value="VDO73952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8BPJ1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO73952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="158" mass="17718" checksum="53DCE590F1982B4E" modified="2019-02-13" version="1">MNLQNSDGPGYLAQHRLFDQIPELLNDIIIPDYCAFGEDGIDNVDMNIWIGPSETVSPLHFDPKSNIFCQVVGRKFLRIVSAAETENVYPRKDGVLTNTSQVDARNPDIAKFPRFGEAHVFDCTLYAGECLFIPAGFWHYVLALDPSISVSCWFTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CB18</accession>
    <name>A0A3P8CB18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018161">
        <property type="protein sequence ID" value="VDO81332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CB18"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO81332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="75" mass="8461" checksum="F3817A6C5118B9C7" modified="2019-02-13" version="1">MFLFFLLVSQGDQEDAFLLRIIEGYTSTTLPIKRGRNGTQSSSVHECDAPQLIVAENEKMFVEEVIGDQVIVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CE97</accession>
    <name>A0A3P8CE97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040795">
        <property type="protein sequence ID" value="VDP16725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I3Q2"/>
    <dbReference type="OrthoDB" id="6161911at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026193">
        <property type="entry name" value="NDUFV3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15880">
        <property type="entry name" value="NDUFV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="92" mass="10562" checksum="C38300D72685254E" modified="2026-01-28" version="1">MLGAVCSIGIQLRSRTLNISNLVRTVYSTGIEHAEMMKQAGMKKKVNPEEYKCSDYFKFEKYSYCDIEAEVVSKRLPQPSNKKPDEERKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXU1</accession>
    <name>A0A183GXU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Male sterility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS51</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000012">
        <property type="protein sequence ID" value="VDO24340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXU1"/>
    <dbReference type="STRING" id="387005.A0A183GXU1"/>
    <dbReference type="WBParaSite" id="OFLC_0000005001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000005001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000005001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000005001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38264" checksum="8EC9462270B2F055" modified="2016-09-07" version="1">MVFKTSLRNLANQTGRHVSPRAPINVAKLDVILNFAVDMMLSPLCLQMGTDCCGKGVLTNMCGSSSAKADIIPVDIVSNLMIVAAAHRTYTKYESIPVIHCCSGALNPVQWHFIVNFIERFFRAYPLNECYRIPSTHFHSSRFLFEFNFYMKHMGPAYLIDLLNAFWGPKIRLTRIYQKVLRLVETLHYFTARGWDFDSKGLLELWETTSDEDKKIFNFDVRQLDWDSYLFDYLMGVKRYVVKDRLEELPKARRNLSWLKLYATIFNAIIWWISVRIFARQRSRRYRWFSGSIGFLLTYIWSNYNFRPPVRLKSLEEYKQRTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY00</accession>
    <name>A0A183GY00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCDC34 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000026">
        <property type="protein sequence ID" value="VDO24571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY00"/>
    <dbReference type="STRING" id="387005.A0A183GY00"/>
    <dbReference type="WBParaSite" id="OFLC_0000010901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000010901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000010901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026106">
        <property type="entry name" value="MAP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739:SF9">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000010901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59540" checksum="DC37277EA786C7C1" modified="2016-09-07" version="1">MKNGHSSRYNDMLDEMLGIRSKEGKVIQKVALSKQMQLVERPPTRHGRNQETIVADQIKNSFSLSFKPDSTNKIDGTIERWQRKGEEEESDDEEEEEKDESNSGSSNVNGTESKPWMKVQKVETGNDNVTIARKITHSPAISIAESGSRSYHSIDTSNDGQNSDQSITTIRQRNHSSGVEPNSLKDILAIEKTNATERQASQGNLCDISRMRSSDITSRNKTDSELRKSVEKHPKTITPNENPSPGKAAYEKWFKEKLKQEREKRRKQKEKEEEEEKARIERKKEAERNYEIWKQRTDEAIRENRRKKKEKAEALTKEKMEEMRRKKEEASKMFQAWKNDRLQRLSKERKQYKQNQENDELKKKREMETRSNEAQKAFEAWYKENKTRSVEAQRRLLKSRKTEEMQNINTKEYKEALAKEAYDVWLQIKENERRFNESLQGRIMKFDEMSRRLHSVPWIPPSNIIPRKFVPTHTRRHQSVKRAIKSNQTSYKKFPSAVHRSKSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY34</accession>
    <name>A0A183GY34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS144</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000035">
        <property type="protein sequence ID" value="VDO24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY34"/>
    <dbReference type="WBParaSite" id="OFLC_0000014301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000014301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000014301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552285" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000014301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8518" checksum="C6D643575A775947" modified="2016-09-07" version="1">MLLMVIGLFIYGRIVMREVLNTLREREGEREGSGKEEGQEINCDIGFIDIGMQQASVKCFCHFSALEVCENSRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYS9</accession>
    <name>A0A183GYS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS389</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000123">
        <property type="protein sequence ID" value="VDO25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYS9"/>
    <dbReference type="STRING" id="387005.A0A183GYS9"/>
    <dbReference type="WBParaSite" id="OFLC_0000038801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000038801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000038801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552308" evidence="1">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000038801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12247" checksum="E6D4E094588909B2" modified="2016-09-07" version="1">MFYQCLGLLFVVSINAINLQHQLKLSFHLNSCSIKFILNQAIFSVPLPEELDYDGEIPNCRDGGKPLLAADIGVYTCDKNCPKGFRCEYRTMDSTSKKGVVNISFTKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYZ9</accession>
    <name>A0A183GYZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS459</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000151">
        <property type="protein sequence ID" value="VDO25870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYZ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000045801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000045801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000045801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000045801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22941" checksum="10FC797718233B80" modified="2016-09-07" version="1">MENCTVTFFESIQNDAKNGTRWIYVEFFNCPSILKINVDTIRAALARWINEECATAIQCSLDNEVEEKNVLIGTLFCGTPNNFITFLVLRNASGDASLQANHLDLNIVGKVIQSREHLLSVLLHSDLKLVTIRVFNEDRKRNITSDIHSLCERLNCTVVILSFFVFIVIFFIICFIQRNFVDRKFIRQSHSLLALQPLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ14</accession>
    <name>A0A183GZ14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Nuclear hormone receptor E75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS474</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000157">
        <property type="protein sequence ID" value="VDO25925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ14"/>
    <dbReference type="STRING" id="387005.A0A183GZ14"/>
    <dbReference type="WBParaSite" id="OFLC_0000047301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000047301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000047301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07165">
        <property type="entry name" value="NR_DBD_DmE78_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06941">
        <property type="entry name" value="NR_LBD_DmE78_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000044">
        <property type="entry name" value="retinoic acid receptor beta isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048008">
        <property type="entry name" value="NR_LBD_DmE78-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF10">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="271"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO25925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000047301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="62742" checksum="0CEAFC415B2D94FA" modified="2016-09-07" version="1">MSFATSAPRKPISPNEVSRGSVFLSARRSSTPIVSGPTTGSAPYSGTPQRPMNLMQNNWNGSVGTFPQLNYLATSDFQQSNTTSGIMSQNGTTNSTSGYLIPSGNYNGMSSYPQQTRLTEVRYCDTSYYGNESVNNAQSHLAALATDELYPDSSTSNKPALCKVCGDKSSGFHYGVTACEGCKGFFRRSIQKQMEYRCLRDGKCHIHRLNRNRCQFCRFRKCLAVGMSRDSVRYGRTPRRKGDEVDNENVPSWEETSKLTHYEVANIANARLRSFIESVTDAHMTCCNYMSTDLKDLEPRVAHHLPNTKSPSANRHQLWHSMNEAMFEDLGRFIEFAKRIPGFMNISHKDQLLAVKTAFFEVWLVWISCTMNSKTGTLTFSHGITFSQEQLSIVYGVVLVKQMFEFGNRFATYKLSECLLGLYCAVLLFTQDNIPKLERPHKVLILRERVMYALKLQLSTERPAESELFHSLLVKRELLRSIAVRHQMALDWYRVHLDLIRLPQIFVDLYDLDSPGLVSKSTFNDSIASLGTDRPIKEEVIEKQDVDLASKGNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZE4</accession>
    <name>A0A183GZE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS604</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000212">
        <property type="protein sequence ID" value="VDO26375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZE4"/>
    <dbReference type="WBParaSite" id="OFLC_0000060301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000060301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000060301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000060301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42957" checksum="912D147A2C13E442" modified="2016-09-07" version="1">MAVSSRNGFRWSLNPLLVIVAFCEFCLGINHLLFCLPFYPFLIPVIAATFAFITAFHGLFLRFPNRMDFVLHCCSAALGLILLMSSITETFCGVDGMLNEEENDSNGHVTSSGMHLFNDFYLFVYRSNRISMLQALCYGLAYRTSSYQKSCNDLLKPFHDSLLFKLDITYHTSSINFMTSFLLSGFALAHTATCIALAYYSAEENGYLIRSYHGQLVIGIMMIPVALLHRFYCCTYFYLWPAVIVGLYTVFQCIITWKHQYRGKFVRLANIFGSGMAMALAAAASFGMFCTLTRFSMNHFAFQRHCNSPEFEYHYCYRVIDFRSPYTEWKREYVIAETSAIQVLINLWLCISAIVLFSFSLKSAFTTEILPGYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZG5</accession>
    <name>A0A183GZG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ferric-chelate reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS625</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000220">
        <property type="protein sequence ID" value="VDO26452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZG5"/>
    <dbReference type="STRING" id="387005.A0A183GZG5"/>
    <dbReference type="WBParaSite" id="OFLC_0000062401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000062401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000062401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF171">
        <property type="entry name" value="OS01G0895300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552313" evidence="9">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="47"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="202"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO26452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000062401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53901" checksum="E1660AA7FA4B473E" modified="2016-09-07" version="1">MNVTNSSITIFIILFVTVCSSQLDLSECRKDKTCLFVSEHCEEMGNCEKIVSYAVQSNEWIIIELFYNTTHPGTNYAAIGFSEDTQMGDDGVTHCGFDEKTNQMNVFLSQNYDKRNRPLNLTAENTTEYVELLQGSHTSDSIYCKFRQKIMPDKAAQNAFVPDLNRTYYLLLAYGETSKYGELGIHSLDTRSEDFPTFISTPVNVATGASAPVKPVKLPTNRFRELDFKKNQPETKISGILMLVGWMWLIPSAIVAARYLREHWPEVKPFDLKIWFHIHRTLNYVAVILAIISVFSVFIGKKWRWTGPSVHKSRERNLSAGAIHSIIGVIAVGVMVIQPISAFLRCDQGSTYRPIFNWSHRCIGLLTFLLGQIAIILSVIFFRLWIARWAVILSYAVYLILIVLLLFLTTKINSLKGKQSTTVSYAGRHYQQEQIVITKAKQDNKTKKLLLLVVMAFSILGAVITIVMAILMLAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZM0</accession>
    <name>A0A183GZM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin_8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000248">
        <property type="protein sequence ID" value="VDO26685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZM0"/>
    <dbReference type="STRING" id="387005.A0A183GZM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000067901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000067901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000067901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000067901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32429" checksum="BDC6B7FDD85F33C2" modified="2016-09-07" version="1">MMSNEGKYFLAKGDTFLLPTNAIYRMNDKLDDASDLSSVYSNEPESAIGDGFDAEELYMDDAEFTRRLYKFGLDINGLPLRDDLLFKTFDKAANFTLKVQELSWWQKFKGIKANPIQANIFFFAVPHIALWDYFGGTSCLDISCIAGDQINVLCEEFQVREIDSITSDGRTFLRLPMQWSLGQWIRKRSFQSNIGLIPSCWLITKSFYDENKKLFDHPTWFLGITDLNNAYDYLLEDRSSYRPAAERAQNDRNAQVTSTLYAPVVKDQTQTGLRFSKVYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZP4</accession>
    <name>A0A183GZP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NUDE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS707</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000261">
        <property type="protein sequence ID" value="VDO26778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZP4"/>
    <dbReference type="STRING" id="387005.A0A183GZP4"/>
    <dbReference type="WBParaSite" id="OFLC_0000070301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000070301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000070301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="124"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO26778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000070301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="27458" checksum="478E2A697CD8EC39" modified="2016-09-07" version="1">MDWEMLVEQYRAEAERYKQETNEAKNELKDFVTFSQQIENELDKELNAANLTLSKREKEIAILTQERDRYKEEVQRFRAEQYSRDMKLNNELQELRVEKENLMNTVHKLEQKNDDLERELRYTLKDTEKRLNEELEMRALLTTELDNKEDLKVRCQRLEDEVRDLKLDGMVKETKLSNCLISNQSNVVSVIQDKRSSGSLIQMKSGKNFILSWRYSDCYNYYIFSKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1I7</accession>
    <name>A0A183H1I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1347</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000615">
        <property type="protein sequence ID" value="VDO29198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1I7"/>
    <dbReference type="STRING" id="387005.A0A183H1I7"/>
    <dbReference type="WBParaSite" id="OFLC_0000134601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000134601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000134601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO29198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000134601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11953" checksum="408B634709093A59" modified="2016-09-07" version="1">MGGSTMKTAKVWKYFIQLPSEEQAAECRICCKRIKATNSRCYFILSLLPRLQFASDLSKVQQILDFSTTGMIRHLRSCHSNEYQVLQAARQNNAAIKQGRMFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1T3</accession>
    <name>A0A183H1T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS1443</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000681">
        <property type="protein sequence ID" value="VDO29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1T3"/>
    <dbReference type="STRING" id="387005.A0A183H1T3"/>
    <dbReference type="WBParaSite" id="OFLC_0000144201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000144201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000144201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000144201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51912" checksum="0DDA1CD83AC31942" modified="2016-09-07" version="1">MRDSVSEARKLIRKFNRGHRRAFSVPNASADRLRMAVVEGNNFSPYAQKQKTAEELKKTVTYISNGLPILVPVSEDDDADLNVKINEDEIVLPNEENAKRKSRVAVRRIWEARWKATNFELLPEWLQDNEYLRTGHRPPLPSFGSCFKSIFSLHTETGNIWTHMYGCVAFIGAAAWFLTRPSTLVQLEDKIVFGTYFIGAVACLGLSFAFHTVQCHSHGVGKLFNKFVLFCYFNYKGKIISLPYFDFIICTEPTYKKIKMIMNLTDSITWFLLHFRLDYTGITLLIFGSFIPWIYYGFYCRLVPMILYSTMISILAIAAIVVSLWDKFVQPRYRPFRAIIFIAMGLSSVVPALDILINNGLTYLLNEASLFWFILMGFLYITGAVLYATRTPEKCFPGKFDLWLQSHQLFHMFVIAAALVHFYGISTTAVKRLEQGSCDEQMLEQYANEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V8</accession>
    <name>A0A183H1V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1468</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000697">
        <property type="protein sequence ID" value="VDO29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V8"/>
    <dbReference type="WBParaSite" id="OFLC_0000146701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000146701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000146701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO29652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000146701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4657" checksum="3BB11AED863C5D0C" modified="2016-09-07" version="1">MHIARAVVLTAAVQLNRSVTTAAYRSYLLVCLCVFGYVCELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2D6</accession>
    <name>A0A183H2D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-formylglutamate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1646</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000819">
        <property type="protein sequence ID" value="VDO30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2D6"/>
    <dbReference type="WBParaSite" id="OFLC_0000164501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000164501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000164501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000164501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7762" checksum="07A38EC1F26E834B" modified="2016-09-07" version="1">MMPYLPISGIFANNTCASRLRGVIARLCGRGWKGAVEGKEVLILCLHVGQNDRWPREAFFMKAFLPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3W9</accession>
    <name>A0A183H3W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2179</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001197">
        <property type="protein sequence ID" value="VDO32141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3W9"/>
    <dbReference type="WBParaSite" id="OFLC_0000217801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000217801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000217801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO32141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000217801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12971" checksum="C7611BBDE8CCC2BD" modified="2016-09-07" version="1">MMRKNDADEPIGFQCVPPTTDHTRRFLDLNEILLHGATHTICEVIVTNNLLLVIFYNIDCGGWRRLYYLEWYYQHGTIEGSTTVIPHLLFIKFEADIKCVFTRLDRCCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H477</accession>
    <name>A0A183H477_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FEZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2287</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001283">
        <property type="protein sequence ID" value="VDO32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H477"/>
    <dbReference type="STRING" id="387005.A0A183H477"/>
    <dbReference type="WBParaSite" id="OFLC_0000228601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000228601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000228601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000228601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30797" checksum="70A85310ACEEE74F" modified="2016-09-07" version="1">MCHQFTVTAVNFFPCVGAAAPNFPLSDNFPYQKLPESPADIDFIRRNKENSDPGIDLSEEDEDLRSALDMHQLISQRGPLSESPPQTADQVIEEIDQMLQSCDFSGSIMTDHTMESMDSMYSSMRSPLPNGQYEMDVKLRQAVAITSNYENLESFSYSRLLALSTEMEQLIQVYNDSLVEQLAHRDELEYEKEMKNTFISLLLSIQNRRRHFTNERKRKPLKIDPSQLPQYMTATIPYDENRLSMDMNMLMALIKCDYFKSLVSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4H0</accession>
    <name>A0A183H4H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001359">
        <property type="protein sequence ID" value="VDO32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4H0"/>
    <dbReference type="WBParaSite" id="OFLC_0000237901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000237901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000237901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552379" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000237901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10669" checksum="924253F5C029E40A" modified="2016-09-07" version="1">MFTFRIILRIYLSLHIALPLASYSVAIEETDVERFFRLHGQPQGCGGQGNEVEKGLLDKDLLEVDKVGKVVEVVDMLLVHNYSHQRTMPDIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4U8</accession>
    <name>A0A183H4U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS2508</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001454">
        <property type="protein sequence ID" value="VDO33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4U8"/>
    <dbReference type="STRING" id="387005.A0A183H4U8"/>
    <dbReference type="WBParaSite" id="OFLC_0000250701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000250701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000250701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000250701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15753" checksum="4BD61E805500123F" modified="2016-09-07" version="1">MNSSGKNNGNSRIIVIEGRGKLEEEDLRGIFKDFDLNGDGYIQKDELNAVMVKMGQCPTDDELNAMFSAADTDQDGNIDFDEFLSIAYANPLSLSLKAIFDELDVDGDGCITRSELRTAFQRMGHTLTDGDIKAIYNQNFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H502</accession>
    <name>A0A183H502_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2561</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01001496">
        <property type="protein sequence ID" value="VDO33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H502"/>
    <dbReference type="STRING" id="387005.A0A183H502"/>
    <dbReference type="WBParaSite" id="OFLC_0000256101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000256101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000256101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000256101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17594" checksum="E4A28BB95F50DBC4" modified="2016-09-07" version="1">MEEAIYLSAEIGVLQIFTDDRQECVPNVVWKTFYDRYGIRFVKRYTTYRYFRRHGWIVRSGLHCGVDFMLYRDGPQYYHSSAAVRIISTGCRRDTSSFIALNRELNSMKKTLIEVIVVIPEDCDIQSIDSIRHISVTHVTALTWKTSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5C3</accession>
    <name>A0A183H5C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH_hydro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2683</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001594">
        <property type="protein sequence ID" value="VDO33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5C3"/>
    <dbReference type="WBParaSite" id="OFLC_0000268201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000268201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000268201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000268201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47243" checksum="580DC4AE8B011B3A" modified="2016-09-07" version="1">MSTCIKACYPRDRLEEITLIGKSWYIKFLSLDMILLRAALVFRNPEAKLSENIKFARNKAIGESLQTEFQIFFSNLKIILLSPLKICVLHTLMTSFAPSLFVFFFHLINNWPKFAVYIFNHSTSSSLEEFIEIKWNRPGKLKSNERGSVFANSASDFRKYYGLVHLSACSSLLRTWQNRTVQSLEWTVSDQYNQQHFCWITQECQTSWLAPKQSNYIVKVSVKLVDHKILHGKARITIRDYWIGVIGDSFASGEDRCHRSSRSWAYKVYEQMTSAIIEQSAVHFTYLPCTGASVDNGILVVFNSTSQINVLEQITRIRGTGPDLLMMSVGGNDIGYSEILSTLIWGPTASLFSTIDMRFFYASYQLDRVAKAIQKLKPNQVVIPHYFDLTRNERGVVDADCADMRQVQFCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H721</accession>
    <name>A0A183H721_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3283</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002149">
        <property type="protein sequence ID" value="VDO35965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H721"/>
    <dbReference type="STRING" id="387005.A0A183H721"/>
    <dbReference type="WBParaSite" id="OFLC_0000328201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000328201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000328201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31430">
        <property type="entry name" value="PROTEIN CBG22332-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000328201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36068" checksum="8E893A1EFB93734D" modified="2016-09-07" version="1">MSRFLPPIVTNDSCRIDSHDLCLSIEPDGRKLYTYTVTWHDLQQIKQSDLVDDMRQPTASPQFSFMNVSSKQVLSAEDIQICKRVAPSNISRSRTRECYCDGPCGKIKPVSEMHIMGRCDHYICQDCFEKAPVVENVDGFGCPNVRCYQTDLAFLSKNSRRRRHKIRKISTMPLRRMASTVTTIDKLFFIDENFLKDEKMPNMLENMPCLSLVDVCLTTFIPLRNSDKICRQQQVVEIYGDYTMLQTLNVLKEYERLSSLDIANRVYYCPKGPINERSSWKHIREEDLSLPITKFGRKDQRIDIIFDCTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H767</accession>
    <name>A0A183H767_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3329</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002195">
        <property type="protein sequence ID" value="VDO36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H767"/>
    <dbReference type="WBParaSite" id="OFLC_0000332801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000332801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000332801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000332801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3585" checksum="B531E928A4F86A28" modified="2016-09-07" version="1">MKSERTVKDSDDRRFVAHLGDKHEEGTLETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H786</accession>
    <name>A0A183H786_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS3348</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002211">
        <property type="protein sequence ID" value="VDO36184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H786"/>
    <dbReference type="STRING" id="387005.A0A183H786"/>
    <dbReference type="WBParaSite" id="OFLC_0000334701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000334701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000334701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF31">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="251"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="357"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="458"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO36184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000334701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61984" checksum="ED86D84BCF1DFDF9" modified="2016-09-07" version="1">DRETLDRHVLKVTAYERLDPSVSASSSVIVEILDVQDNAPIFERNSYYAEIREDAPIGTTLASVFARDLDMGLNGEIVYSIAEEPGADLLQIHSSTGVIQTAQHLDRESMNLIRVYVYATDKGVPPMSSRALLEINLLDVNDNAPVFEEEFCNVTIMENITIPSNILQIKASDNDSGQNGIVRYSIVASSVNGFSIDYESGWIKLHQRLDSRSNPATLLVRAKDSGQPAQSSTINCAIYITDINDHKPHFIASQQELFVEENVPVGFEITRIFAIDEDNDMNGRIVYKLEGEDNANETFRIDRTTGVITTISKLDREKKEKYILKVKAEDGGEPPLSDSLLIMITVRDINDNAPNFEPNFYNITIAENEVRGTPLITVKAIDHDIDDKIVYRIERADKDIFSLIHSADQGAILSLSGKIDRMDDILHVIITATDKGGLTGTCTITITVIDINTAPVFLIHPFTIHIPENIPIGSEVIQLKAEDQDRHENAKLTYSVDSEEFNINKDTGIIVVAEELDREEQSNYLLNVTVTDHAANSLGASTLLEIILDDSIYFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H854</accession>
    <name>A0A183H854_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS3666</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002534">
        <property type="protein sequence ID" value="VDO37354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H854"/>
    <dbReference type="STRING" id="387005.A0A183H854"/>
    <dbReference type="WBParaSite" id="OFLC_0000366501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000366501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000366501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO37354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000366501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19781" checksum="986061779579B9E1" modified="2016-09-07" version="1">MINLSGKSGKAATRGQKQIYEENQTVILYYSVAAIFSSVFYILISLFFFLRTAWEWLGFSICCVLQIAAILTMRSMARCRRNERGQVTDAGSDLNQPDAFGEYCKDVVILCSFIATVATIWSTILWLLLVIPAYVLYKLWKVIIAPWFFAEPLEQEEEKKMKKRERRLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8Q3</accession>
    <name>A0A183H8Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3865</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002732">
        <property type="protein sequence ID" value="VDO38022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8Q3"/>
    <dbReference type="WBParaSite" id="OFLC_0000386401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000386401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000386401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000386401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18846" checksum="DFE0E71803596602" modified="2016-09-07" version="1">MNSNFEFSFSTVVDSTNFIYNYERIPKILLLQLSCDSESLCFAGRHSEYHLCEYLLTLYLRLVDRLGFYIVENAMYRLGGVKCVGGNDGINAAAVVVMMAWIRTVNDLVTFQAWIRTVNDSATLQPNVLIRGILSPLPVTDLFCGTARHGFSDTARARRCRNITLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8S6</accession>
    <name>A0A183H8S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-processing-splicing factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3889</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002758">
        <property type="protein sequence ID" value="VDO38117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8S6"/>
    <dbReference type="STRING" id="387005.A0A183H8S6"/>
    <dbReference type="WBParaSite" id="OFLC_0000388701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000388701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000388701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROCN" evidence="1">
        <location>
            <begin position="54"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="2">
        <location>
            <begin position="628"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000388701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="87182" checksum="726B2C2C213CC100" modified="2016-09-07" version="1">MRRATAASANKSHKIVVDTFTKRFYKEPSPIDDEDFILPEEVEPIFSETPLYTENTGNGIALMWAPRPFNMRSGRTRRAIDVPLVKSWYREHCPSGMPVKVRVSYQKLLKVFVLNALRHRPPKPQKRRYLFRSFKSTKFFQSTTLDWVEAGLQVLRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLNNVDAYQLADGLQYIFSHVGQLTGMYRYKYKLMRQVRMCKDLKHLIYYRFNTGPVGKGPGCGVWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARVILQHLSEAWRCWKANIPWKVPGLPTPVENMILRYVKAKADWWTNSAHYNRERVRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKNRLNQSQREELALIEQAYDNPHEALSRIKRHMLTQRAFKAIFKDQSFLRFQEVGIEFMDLYSHLVPVYDIEPLEKVTDAYLDQYLWCQGINNLQEVWDTVEGECDVMLEARLEKVYEKMDLTLLNRLLRLIVDHNIADYMTAKNNVLINYKDMNHTNSFGIIRGLQFASFIVQYYGLVLDLLILGLRRASEIAGPPQCPNEFLTYQDVATEIVHPIRLYCRYIDKIWIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9B4</accession>
    <name>A0A183H9B4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS4076</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01002961">
        <property type="protein sequence ID" value="VDO38786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9B4"/>
    <dbReference type="STRING" id="387005.A0A183H9B4"/>
    <dbReference type="WBParaSite" id="OFLC_0000407501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000407501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000407501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CBP/p300-type HAT" evidence="16">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="15">
        <location>
            <begin position="343"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="13">
        <location>
            <begin position="343"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO38786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000407501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66594" checksum="4D4AA53B55DA3EFE" modified="2016-09-07" version="1">ASLSRRVYIAYLDSVHFFQPRQLRTEVYHEILLGYLNYAMMLGYTMAHIWACPPSEGDDYIFHCHPPEQRIPKPKRLQDWYKKMLDKGVGEHTVFDYKDIYKQARDENLVTPMELSYFEGDFWPNVIEDCIREAQNEEQERKRQEEAARQEQQNAEDEDGDDMFHDGDNGKSKKNSKKKNNLKKGNSKNKKKVCSQTGNEVTDKLYINFEKHKEVFFTIRLMSPQSELSAQNNEIKDPDPLIASDLMDGRDTFLTRARDEHWEFSSLRRAKYSTICFCHALHNQEKSEGLSYTCNSCQGTAIWHCTTCEDFDLCNKCYETMSHPHKLEKVSTLVEVEDKHDASNSRTESIQRCIQSLVHACQCRDANCRRSTCHKMKRVVQHTKGCKKRQNANCAICKQLIALCCYHAKHCNGTSCQVPFCLNIRQKLQEQRRSQNRRADMMMRRRMDMLSSGYGGTNTPGPSQSSGPAGALNISQTVTTHHGTGPMQSYQGTGMTHMHHVQMGQPQGVMASGQQQMAQMQQLQPHQYQTHGKGANAYMLLVNVINMLLITGGAVQGSSQIHMMGVPTTIQQSHAISQVQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA01</accession>
    <name>A0A183HA01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4313</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003219">
        <property type="protein sequence ID" value="VDO39594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA01"/>
    <dbReference type="STRING" id="387005.A0A183HA01"/>
    <dbReference type="WBParaSite" id="OFLC_0000431201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000431201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000431201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000046">
        <property type="entry name" value="Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO39594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000431201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28294" checksum="A4350CD30E97B47B" modified="2016-09-07" version="1">MTESNSEDVRLLIRCALQSFDDLSISCRSSWTVLQLKEKLAVDCPSKPEAKRQRLIYAGHCLHDEDTLKSVFELRPIDDGNVHVIHLVYPPKDFNTHLDASVLRRRNVNHTQANSTSLETATQAQTHNVNNAFPLYTYPSWTSTAPQGGFVTPQPMLVSSSAHFQRAYQAYVISYSNYMYQMMSALENSGSNGVQFSSQLLSNNQRTVLQPPQQANQPERVCFSSFINKSYSKLNKLSKIYQLLLLILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA99</accession>
    <name>A0A183HA99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003332">
        <property type="protein sequence ID" value="VDO39920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA99"/>
    <dbReference type="STRING" id="387005.A0A183HA99"/>
    <dbReference type="WBParaSite" id="OFLC_0000441001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000441001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000441001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000441001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33226" checksum="5A271F502DE8C53A" modified="2016-09-07" version="1">MAWTLLVSREQPAGVSHLCLRILFKKGRSQSLMMFNEELKLQTYKWLSKRYFPKLVFKLIAACDHSPTGYITTNPEDLFSRRYRRGNSESVRHLSVRVRVAEEEVKKYRLQNEDLKKTVAKMTKELCDKQYEMESLRKTFEQQVDGLQHQLSKKEREDKQSKFEAIMSLLQGNAGPPKIYEPPFSFLDEPKPETVNVEAQTDDWMLRSIQKSVNAAVAGPSVISKCNADNESNDAEKCGKMAEEIAKLENEKFFLTTQLKLTRNKIVGFFLDNLEIVADQQFIIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAJ7</accession>
    <name>A0A183HAJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003456">
        <property type="protein sequence ID" value="VDO40195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAJ7"/>
    <dbReference type="STRING" id="387005.A0A183HAJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000450801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000450801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000450801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000450801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11498" checksum="82A983B10349F9C5" modified="2016-09-07" version="1">MKSNWITVDNCETIDRNTRPFYNVGLAVVNDQLYAVGGFDGTTYLKTVEVYDRETNQWRQSGCMTYRRLGGGVGVVRLDHDQYVPFNSDPDLAPFDDPPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAN4</accession>
    <name>A0A183HAN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003496">
        <property type="protein sequence ID" value="VDO40291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAN4"/>
    <dbReference type="STRING" id="387005.A0A183HAN4"/>
    <dbReference type="WBParaSite" id="OFLC_0000454501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000454501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000454501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000454501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20272" checksum="C2B7EB5AEDE84394" modified="2016-09-07" version="1">MKMTKSSDLDGGFSQSLCCRRPCNAMAPKALFINGECMPRGQLNSQCTANEQCGGGESMICNRGQCECLAGFHPLVDPVTHPLRNPSQTCTRDCESEVLSRDTTCLKPVALEAHCFIQKQCPMNSGCYRQCKCGFKKEKQRCVELPPSPTTTKQPSVPASVIVPGGDFLSLIGNFFRGTEPRSAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAR0</accession>
    <name>A0A183HAR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4572</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003531">
        <property type="protein sequence ID" value="VDO40375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAR0"/>
    <dbReference type="STRING" id="387005.A0A183HAR0"/>
    <dbReference type="WBParaSite" id="OFLC_0000457101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000457101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000457101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000457101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35123" checksum="B68B7871D5A7E316" modified="2016-09-07" version="1">MSDANVPSRTLHDIITEKIEKKEAELELRSVCPEDDDFVIKQMDPAVVEMYREIGLVLSRYRSGKIPKAFKVLPKMMNWEQLLYLTNPDKWSAAAMYQATRIFASNLHSRMCQRFYNLILLPRLRDDIMEYKKLNFHLFQALHKAIYKPQAFFKGILLPLCESGTCTLREATIFGSVLAKASIPMMHAAVAMLKIANMEYTGSNSLFLRILIDKKYTLPYRAIDALVNHYLRFRKEERQLPVLWHQSLLAFAQRYKNDISDEQRVALLELTKVQNHYQITPEVCRELISAKKKESEIESASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBT4</accession>
    <name>A0A183HBT4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS4947</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01004014">
        <property type="protein sequence ID" value="VDO41540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBT4"/>
    <dbReference type="STRING" id="387005.A0A183HBT4"/>
    <dbReference type="WBParaSite" id="OFLC_0000494501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000494501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000494501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="173"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO41540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000494501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40043" checksum="F7C54E0E81A3AC1C" modified="2016-09-07" version="1">MFLFNLRENSDINTADSVSYHIEQCCLAFLKSLVNISKNPSGYIILSNPRAIDNKAHKLKLTPKNSRLIAQMLRTISMIYQLRISKACKTKRDLFYEQKNLFGEQRNLDKSINRIYCWLGMDPTSGYLLSSGHGLVIGQLKIYGSTGIVDCSLKATIIDDFSRSNLFTTAQCILVVEKDAIFQELIGEGFLKLFPNALLVTGRGYPDIATRIMLKKLSNLPLFGLVDCDPHGIEIAMTYKYGNCSKKFDVANRELSHFEWIGLSRCKLPKFVISVVQFLPLQKRELAKLEKLYQRTAILGNEILLKELVSMRQHGNKLELEAVSGVAPGSMCQYLLRTKLSKYAALEEKLALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBY8</accession>
    <name>A0A183HBY8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5000</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004087">
        <property type="protein sequence ID" value="VDO41730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBY8"/>
    <dbReference type="STRING" id="387005.A0A183HBY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000499901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000499901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000499901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO41730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000499901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="55213" checksum="172B679BE7E675CE" modified="2016-09-07" version="1">VESFFILIGHFIINKNSKLCSFVAGVIHRERLPAFERLLWRACRGNVFLRQSEIAEPLIDPTTGDPVINTVFIIFFQGDQLKTRVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVAASKNVRMWLTKVRKIKSIYHTLNLFNLDVTQKCLIAECWCPVADLNRIQLALKRGTEESGSTVPSILNRMSDITEAPPTFHRVNKFTRGFQNIVDAYGIASYREINPAPYTMITFPFIFAVMFGDCGHGLIMLLCALFFIYREKRLESARINDEIFQTFFNGRYVIFLMGCFSIYTGLIYNDVYSKSFNLFGSSWRNIYSNLNKLEYERELMLTPQWAYYNVVGHLYIFLRFFLKLFSVGPYPIGVDPIWNLAESNKLSFLNSMKMKMSVIIGIAQMTFGVMLSYENYKYFNSRLDILYMFIPQMLFLGCIFIYLCMQIVFKWLLFSAKVGILVFLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCI0</accession>
    <name>A0A183HCI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terribly reduced optic lobes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5192</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004330">
        <property type="protein sequence ID" value="VDO42333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCI0"/>
    <dbReference type="STRING" id="387005.A0A183HCI0"/>
    <dbReference type="WBParaSite" id="OFLC_0000519101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000519101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000519101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105:SF0">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO42333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000519101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17953" checksum="D121E396E1F3414B" modified="2016-09-07" version="1">APLYGRRGDLSEATILNVKADIRSDWCNCRRMNEADVDQFDDDFEDDERLMQADRPSIIHRTRHFRQRKRRKGCGASRHGHQQMLCPTRSSHHYDVCITSEQLCDDIVDCPGGEDENPSNCLFYKSIKDQLKHIYNTVLLLADHAAGQNNNHREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCU1</accession>
    <name>A0A183HCU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5306</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004490">
        <property type="protein sequence ID" value="VDO42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCU1"/>
    <dbReference type="STRING" id="387005.A0A183HCU1"/>
    <dbReference type="WBParaSite" id="OFLC_0000530201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000530201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000530201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000530201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8543" checksum="4FA6B51D078C7CC0" modified="2016-09-07" version="1">MVYPCHGLKGNQEWKYLFYKNQILHVITNKCLEMSRDGTRLIMNVCDQTNPHQQWLVQEFNQTLAKQYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD26</accession>
    <name>A0A183HD26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS5388</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004602">
        <property type="protein sequence ID" value="VDO42972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD26"/>
    <dbReference type="STRING" id="387005.A0A183HD26"/>
    <dbReference type="WBParaSite" id="OFLC_0000538701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000538701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000538701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO42972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000538701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39350" checksum="867313E659648F21" modified="2016-09-07" version="1">MAVNAVKKIVNSDDNNVDLRMIKIIKKVGETVEESRLVDGALIDQRSMGRGGPTRVEKAQIGLIQFQLSPPKTDMENQVILSDYTQMDRALKEERTYLLDLCKQIKKAGCNVLLIQKSILRDAVNEMSLHFLAKMKIMVVKDIEREDIEFYSRILGCRPIASIDHFVPEALGSADLVEQIPTGGDGKIIQVTGVQNPGHAVSVLIRGSNKLVLEEAERSFHDALCVIRCLIKKRALLPGGGAPEMEVAVQLRQLAQERFGAEQYCWRAFADALEQVPYTLAENAGLNPIATVTELRSQHANGKKNHGVNVRKGYVTDIREENVLQPLLVSSSAIKQAAECVRSILKIDDIVSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD29</accession>
    <name>A0A183HD29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004605">
        <property type="protein sequence ID" value="VDO42978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD29"/>
    <dbReference type="STRING" id="387005.A0A183HD29"/>
    <dbReference type="WBParaSite" id="OFLC_0000539001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000539001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000539001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000539001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8067" checksum="AA55509F5657001E" modified="2016-09-07" version="1">MNLHFAAEIYDEELIMIEDLCSQMANEVPNQLGIPSPNRSASASYDVDCIANKITIRLTFSQTCNQIFLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD75</accession>
    <name>A0A183HD75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5437</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004669">
        <property type="protein sequence ID" value="VDO43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD75"/>
    <dbReference type="STRING" id="387005.A0A183HD75"/>
    <dbReference type="WBParaSite" id="OFLC_0000543601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000543601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000543601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000543601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44816" checksum="E9AA31EE32658D56" modified="2016-09-07" version="1">FFIFQEILYTPRQGIRCRIDGIRPLNHEEKWPEEVQKCIDNLLAPSASFEAIFGSPNKDGVYPIKVMVLRNQLIEKDSFGMDEANNANNKIELVSWLVAKGYAETQDIWRKYPVKNLLFDGKHEYTMIITEVDGQIIRARPYVFAEQYNKMKKALANIELIPLGTDATTGLITLNKENKRAMLISTANNASSKKCLLVDEGICIEEIPVQFYGSKELYDSDSFLVRTCHRLSVQCRFTKFLLDEESRQMILSSAASGPAKVILTEYIEDSYLISDIFFSDRTTLIEKVKKAKQGKIDEKESVLGFVANDLQQASGGNLNQSEKAEDLRLPTIGKKEIECSQNLVIDENSYLKPQVSEIKVYISDDTEKEYKTFDPEIITFMDSLVASVSKFDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDH4</accession>
    <name>A0A183HDH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5536</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004811">
        <property type="protein sequence ID" value="VDO43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDH4"/>
    <dbReference type="STRING" id="387005.A0A183HDH4"/>
    <dbReference type="WBParaSite" id="OFLC_0000553501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000553501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000553501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000553501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5560" checksum="E512B819DB532D09" modified="2016-09-07" version="1">MFWDEQNWLPRGVSWNDLKSNDTIRYPDIWELTYAMKYAFEYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEK8</accession>
    <name>A0A183HEK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5920</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005354">
        <property type="protein sequence ID" value="VDO44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEK8"/>
    <dbReference type="STRING" id="387005.A0A183HEK8"/>
    <dbReference type="WBParaSite" id="OFLC_0000591901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000591901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000591901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043581">
        <property type="entry name" value="Axin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF2">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="4">
        <location>
            <begin position="293"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000591901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42353" checksum="8279428DA2933877" modified="2016-09-07" version="1">MKTPYICNATTSKNDSAVSSTFSSDANGQHPTVKLSTIREEQLKGNPATHTLARVERVDGGSMVTHCTEEGRRAFAALLIEKLNVLSARRKRNDVMSQQLRAIESRKCSAREVVNDVEPTVAEEDDELERYVRQRMADDSSKPSPSYHSPDSLNTQSLRFRRRSPRSSSPEHFRQYVASPIANVFYAPNPYSSNGFAPPPINRHNRMTNVNPVILKGARCDMKSMAIYDTSGIESMAPSSVSERDDAARAAIFQKARMLSYGSCASNSSSGRRSTHKQHHDFNSLSRSRGTESKQLVTISYKEKGRVPVVAHVPTHPITFREFRKYLGISSKSSLQFYFKTACEDGNSPYQLLLVNDDATVLPVYEGRITAECKSISDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HET0</accession>
    <name>A0A183HET0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005455">
        <property type="protein sequence ID" value="VDO45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HET0"/>
    <dbReference type="STRING" id="387005.A0A183HET0"/>
    <dbReference type="WBParaSite" id="OFLC_0000599101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000599101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000599101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000599101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29694" checksum="B4CE0B7CA7225A8A" modified="2016-09-07" version="1">MTDEECEIFVAYFGTIEIRRDVAKSRIILRNYLLQRISRFQVDGIIKNISFTHNYIFGLAPSDHRIYILRIDSFFVYSLDLDAISENLKFEHLASIIVETERMDGKVSCNDTQIPELAHCKIERTEESMKSNLNKIEDFLICTTNQSCFLARNMANNEPSIYRIFTENKTNDFQLLQFGSAQSIRQLSAGNDHILILTVNGMVYSMGTGSRGELGHGTVECEQQPRLVECLSSLIVVQVACGGWHSVALTDDGDVYLWGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFJ9</accession>
    <name>A0A183HFJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6261</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005847">
        <property type="protein sequence ID" value="VDO45942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFJ9"/>
    <dbReference type="STRING" id="387005.A0A183HFJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0000626001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000626001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000626001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000626001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37776" checksum="D0E7CE102099ADB4" modified="2016-09-07" version="1">MKTFGDDIIRRRGQSNADFGKEIRLLVICLDIPGEEMLITLIKKPFIKVIRSNQTNMTYNRKVENVYKISFQTWLPPSPPPSDNGDDIYYDSTGEYWFEQLPMAESRLPTTIHELHRPRPLTPTSSLLPEQFVPEIIAPSSIPYQLAPGVVPPNVAMPPIVALPPSPTGMCTVASGIVRDIVSSPTASLSSLSHERSINLIPQTGVSTGAAYLDTSNLLRPATPSRLPGSVDDAIDSVRKSAQKAASVQGTHRSQVGSGRPGLLDSRCGKAELRRPFTPPPRYREAIDYEGSEWSIAEDYEALMILTELQRLPNHLHSAKIGQYANWDMVSVLLATSSEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFL4</accession>
    <name>A0A183HFL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6276</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005870">
        <property type="protein sequence ID" value="VDO46003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFL4"/>
    <dbReference type="WBParaSite" id="OFLC_0000627501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000627501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000627501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000627501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16520" checksum="C7909C087F8498D6" modified="2016-09-07" version="1">MPRGALRQVQNISTDAMWKGGELKRSKTITTNAKAPYDCCTSKYINCMKTRKDGNEQNGAKTENWNLKRTLVNIEENLNETKVRKVELLHESSNTVEDGKEQNGAKTESRKLKRILVNIEENLNERKVLELLHESPNTVEVFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG17</accession>
    <name>A0A183HG17_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS6427</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01006106">
        <property type="protein sequence ID" value="VDO46507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG17"/>
    <dbReference type="STRING" id="387005.A0A183HG17"/>
    <dbReference type="WBParaSite" id="OFLC_0000642801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000642801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000642801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060169">
        <property type="term" value="P:negative regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF43">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO46507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000642801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17188" checksum="5564BE67532B508A" modified="2016-09-07" version="1">MKAAKRGIHRTVHAGESSGAKEVVNAIEEMRAERIGHGYRLLRDENAYKKYAIEKRIHFEACLKSSVMTGSVPLIWSQHPVKRFAADNINFSLSTDDPTCFDNSLLSEYQLAYQEIGLTRKQLWNCSLNAARSCFAEEPLKSEIIAIVEGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG36</accession>
    <name>A0A183HG36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006136">
        <property type="protein sequence ID" value="VDO46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG36"/>
    <dbReference type="WBParaSite" id="OFLC_0000644701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000644701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000644701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000644701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24402" checksum="18710D1E1B72BB5E" modified="2016-09-07" version="1">MCLNNSGIFTLAELSAADDDNVGMLYDIPMPEPLFHSNELNNQGSTSECLNDEVHTAVEQSYIESSSLSSRRSEIFTAALRNDSSFLTNRVDTVGFNINFRTIPCLRIKRNEQPQIVELKQLATTNLQKRIAEVVNRCGDLVKTQLPNCDNRKIAECIRTLNPRKLSKKDALWFDVCYLVAQREWFVLRVKLAKLTNEKLDKNKIIKVLGRQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI13</accession>
    <name>A0A183HI13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7124</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007222">
        <property type="protein sequence ID" value="VDO49432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI13"/>
    <dbReference type="STRING" id="387005.A0A183HI13"/>
    <dbReference type="WBParaSite" id="OFLC_0000712401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000712401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000712401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO49432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000712401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16835" checksum="01A5C8E5A2E4C349" modified="2016-09-07" version="1">MELAAGDRLPEMPTSRLSVVNDPSENRINCHISNITTPGKKESNSRARVLFTYSPKHEDELALREVGQIIEIVSKSNEDPGWLLAEVDGRQGLIPDNFVEILRPTVSTSTINSDTQKVSFKFFFFFGEVEEEEKRRRQRNEVKGILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIA2</accession>
    <name>A0A183HIA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007378">
        <property type="protein sequence ID" value="VDO49857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIA2"/>
    <dbReference type="STRING" id="387005.A0A183HIA2"/>
    <dbReference type="WBParaSite" id="OFLC_0000721301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000721301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000721301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000721301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28017" checksum="83A29B74CDAE0F22" modified="2016-09-07" version="1">MRACSFGKPVIPSSDQLELNTKHLTDYEECKEDIHKYCIRPGMELKSDMSVLECLQDVKLSETELLTAPCEHLVWNFKVNLTQDDHFRQASKLFCKDEMMTNSAMAQCAEKTEPGHALSCFIDFILNLPKESRCFQFLDRSARLAFSDFRVVGPFVAVCKNSIQRLQCGTLTPPSAHAKVRVPHSQGHTLECLISKMYQAQQKDPNAAPIVDEACQHEVMRIAELQTEDFHLDRPLYFACREDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIA7</accession>
    <name>A0A183HIA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007394">
        <property type="protein sequence ID" value="VDO49882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIA7"/>
    <dbReference type="WBParaSite" id="OFLC_0000721801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000721801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000721801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000721801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5378" checksum="F58A58837E375800" modified="2016-09-07" version="1">MRCEKETNEAISIDKFFAAFASLIEIVKFFRHKLKVRNTRNISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HID9</accession>
    <name>A0A183HID9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007435">
        <property type="protein sequence ID" value="VDO50043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HID9"/>
    <dbReference type="STRING" id="387005.A0A183HID9"/>
    <dbReference type="WBParaSite" id="OFLC_0000725001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000725001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000725001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000725001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36719" checksum="6422D8E547E6F86E" modified="2016-09-07" version="1">MREIVKNHKNSTNQEKNDLLNVFEKILNHKIPEHFIIEKEKKKNVEQQISPKLNQWLKAFGKNKSPIAKRKIPPKEKVIETQQFTRPKPPKSKVKSNKKPDYHKPDGPLIVGGIPPAIMPADAPQAPNPYGYDPLASVTPLGHKQLPSAYRRTPDMAKAPPSQKFRLQPQLHKIVLDTSEKMETMPEKISDKSWSTGVTSVPGPSNDYKSTEHEIKTITVAQVDIERSINHNESWRSHRDRDKDNQRENRYTVKEEYPELQYRSPLVRPGPMVQSYSYFCKIDILRISSASKLGQNSYRCSSKTFKRRHTDSFSAADCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ61</accession>
    <name>A0A183HJ61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS7522</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007911">
        <property type="protein sequence ID" value="VDO51367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ61"/>
    <dbReference type="STRING" id="387005.A0A183HJ61"/>
    <dbReference type="WBParaSite" id="OFLC_0000752201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000752201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000752201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO51367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000752201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20818" checksum="09044C594C290E59" modified="2016-09-07" version="1">MVKRHLSTSLYFTLISFTTIGFGDVLPSEPAYIAYIGVCLLIGLALVSTVINVIQQQIEALATGMDKSIDNEYKDALENAKYDERDFIRYSDNDKDNDDVNNDIATQEFPKKDEEPLISFDKILSKMPLKNHVLYKIMPEVSKKQIVKKVELRGKQRVKSTQTDTSLLETLVNFFFALLVCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKT3</accession>
    <name>A0A183HKT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS8097</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008897">
        <property type="protein sequence ID" value="VDO54011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKT3"/>
    <dbReference type="STRING" id="387005.A0A183HKT3"/>
    <dbReference type="WBParaSite" id="OFLC_0000809401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000809401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000809401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.930">
        <property type="entry name" value="Mammalian shaker kv1.2 potassium channel- beta subunit complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO54011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000809401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16263" checksum="96F240320606093F" modified="2016-09-07" version="1">MRVARIFKLARYSSGLKSFGLTVKTSLPELSMLTLFLLTTVIFFSTLMYFAERDEPNTKFKSIPHAGWWCIVTMTTVGYGDYYPETLFGKLIASCASISGVLVLAFPITMIVENFSRNYDSERNDFKRIQRRRRLAKSYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLJ8</accession>
    <name>A0A183HLJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIK helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009383">
        <property type="protein sequence ID" value="VDO55277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLJ8"/>
    <dbReference type="STRING" id="387005.A0A183HLJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0000835901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000835901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000835901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000835901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="24471" checksum="5A3A7B2D8109B489" modified="2016-09-07" version="1">MLLRERHCVKINYYLLVINAAAFTKQTGVDRLQKRTKEYGERLIEHVDWLDRLTFPRIEQIKKEREVEQRCLYLIVEMARVVCGDCIYSVVYYEDEEETGARSVYPLVDPEMDLENLCELKHHMMTRSSRAGFIERELKPNASARLYLEKIIQLPPTHAINIEERDLIWKFRYFLRNNRKALLKFVRSVSWDKNEEAAYALVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM88</accession>
    <name>A0A183HM88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal_L18_c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8597</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009863">
        <property type="protein sequence ID" value="VDO56437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM88"/>
    <dbReference type="STRING" id="387005.A0A183HM88"/>
    <dbReference type="WBParaSite" id="OFLC_0000859901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000859901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000859901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO56437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000859901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15086" checksum="028C166B77615FB9" modified="2016-09-07" version="1">MVKGRTKNTFQSSEEEELIILALISLTKYASAYATGLLLARRHLLKIEDERAPSRAVLDVGLARTVTGAKVFAVVKGVADGGIDVPYSKTRFFGYNSETKYNAEAHRNRILEKHVTDYMTLLKEIDEDAQKQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMX9</accession>
    <name>A0A183HMX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8843</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010335">
        <property type="protein sequence ID" value="VDO57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMX9"/>
    <dbReference type="STRING" id="387005.A0A183HMX9"/>
    <dbReference type="WBParaSite" id="OFLC_0000884001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000884001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000884001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000884001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10976" checksum="1609DEB356BE1612" modified="2016-09-07" version="1">MAPEVVLGHTRHGRKADIWSVGCTLVEMLTTKPPWNDLEPMAIIFNIAQHNPSYELPLGVDPVLAQLISMTFERDVDKRPSASQLLNNLASYRFSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNK1</accession>
    <name>A0A183HNK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS9064</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010748">
        <property type="protein sequence ID" value="VDO58568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNK1"/>
    <dbReference type="STRING" id="387005.A0A183HNK1"/>
    <dbReference type="WBParaSite" id="OFLC_0000906201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000906201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000906201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO58568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000906201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8749" checksum="D775490BEC3D06E9" modified="2016-09-07" version="1">MNGKLWWSAISSRKTIGHSIKPLDDIIVRFATTHFGFQEVDEKEKSKKVHAVFASVANKYDLMNDAMSMGIHRLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNQ2</accession>
    <name>A0A183HNQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9115</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010851">
        <property type="protein sequence ID" value="VDO58764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNQ2"/>
    <dbReference type="STRING" id="387005.A0A183HNQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000911301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000911301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000911301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000911301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17327" checksum="CCF9E2EFEF3BE43D" modified="2016-09-07" version="1">ATVKQAAAIVENAVATVQASENESRPATKAETEVSEKLCPATKAEEKVNEKKDSKPTSAAGKKIEHVNSSVATKDVKNTTAPASEKSTSETGSEGSLKEKPSTASKNKSSTKRNSSSDSKPGKMKADSAIEQVDDIEVHERPQISEAICGKLLVTLMIAMAREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP71</accession>
    <name>A0A183HP71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9283</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011226">
        <property type="protein sequence ID" value="VDO59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP71"/>
    <dbReference type="STRING" id="387005.A0A183HP71"/>
    <dbReference type="WBParaSite" id="OFLC_0000928201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000928201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000928201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000291">
        <property type="entry name" value="Transmembrane matrix receptor MUP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000928201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15651" checksum="DA480BFB992ABFF7" modified="2016-09-07" version="1">MERNFFTNLLTTPGYIIGPGGKCQASGTCQPYLPNACDQRRNEECLPDDYGGFTCQCPVNQIRHPVTQICCKFDLCQIDENRLVDECASGIHDCDRNANCINTDEGYICTCKEGHIDESPDQARKPGRVCRPRTCLFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRJ0</accession>
    <name>A0A183HRJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3694 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013128">
        <property type="protein sequence ID" value="VDO65848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRJ0"/>
    <dbReference type="STRING" id="387005.A0A183HRJ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001010101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001010101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001010101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001010101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19265" checksum="4C95479EF58CF95F" modified="2016-09-07" version="1">MLDNEEDAKKGFTVCPQEKNCFKLRRDREKRVVVVLQQTHGERVLTVKKCFGLLLGAGRNLRHNDMHLLDMQSMGRGNDAKTYIIEAIWDPHLQNLEVLNTETPRETRVFMTIAADVILTGIDEPVRFNMECKARIFHEHERFWYVSRRPVVEKYFLTAKVCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRT2</accession>
    <name>A0A183HRT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10199</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013336">
        <property type="protein sequence ID" value="VDO66613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRT2"/>
    <dbReference type="STRING" id="387005.A0A183HRT2"/>
    <dbReference type="WBParaSite" id="OFLC_0001019301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001019301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001019301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051073">
        <property type="entry name" value="ZNRF3_Arkadia_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16200">
        <property type="entry name" value="RING ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO66613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001019301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13818" checksum="6FF674C79D074EE2" modified="2016-09-07" version="1">MEIRKFEKNGNFEVNTIDKLPKKRSLLCFASKRRYLPVFGSLASVARSQNGQERCSICLEEYKEGQELRVLFCGHEFHPKCVDPWLLSNRRCPLCQYDVVYKEYPKTENKTKNHQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSA2</accession>
    <name>A0A183HSA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10361</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013741">
        <property type="protein sequence ID" value="VDO67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSA2"/>
    <dbReference type="STRING" id="387005.A0A183HSA2"/>
    <dbReference type="WBParaSite" id="OFLC_0001036301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001036301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001036301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF2">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001036301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15841" checksum="2A7D6F1E0B658A98" modified="2016-09-07" version="1">MDRIRRSFQESFRRRISRQHFVRRTPPGRHSSTKRAMNSGSTKSELWQPDEIAVRNGTCSFTVKYLGGIEVFEARGMQICEEAMKLLRGQRRPPIKAVLYISGDGLRVVDQESCRGLIVDQTIEKVTFFFFILNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT36</accession>
    <name>A0A183HT36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10646</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014411">
        <property type="protein sequence ID" value="VDO70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT36"/>
    <dbReference type="STRING" id="387005.A0A183HT36"/>
    <dbReference type="WBParaSite" id="OFLC_0001064801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001064801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001064801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001064801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8330" checksum="1E56BBBE55D4BFD0" modified="2016-09-07" version="1">MMNNNGLVRMPTLEMTPRHRLAMEVIDFSNNHIEYLGDGQLRAVHANKIRLSNNHLREIGSHIFANCRFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTJ5</accession>
    <name>A0A183HTJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014831">
        <property type="protein sequence ID" value="VDO71433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTJ5"/>
    <dbReference type="STRING" id="387005.A0A183HTJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001080701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001080701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001080701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552624" evidence="1">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001080701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12948" checksum="F2004ACD273CD67D" modified="2016-09-07" version="1">MIVFAIITVTVLLVAEREKGEKSRLTSVERVRVRLRTTAYELLKYYVYFQGINTSEVLTHSIESRDWLSCAEPTAVRSAMKHFISDLAAIDSAIKPFVSFLQMQIFHCGVKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTU0</accession>
    <name>A0A183HTU0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS10905</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01015106">
        <property type="protein sequence ID" value="VDO72289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTU0"/>
    <dbReference type="STRING" id="387005.A0A183HTU0"/>
    <dbReference type="WBParaSite" id="OFLC_0001090201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001090201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001090201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO72289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001090201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12187" checksum="94466DCDB8F0F6AB" modified="2016-09-07" version="1">METQAGTYVKEFVHGDFGRTRPSLADLLNVECGEIDILELDVEGVDMEWPPKYWMHNDRLIAKTFQNSPYMDYLQILLMVMRTGRKLKYVGNFVACTISVSMEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU64</accession>
    <name>A0A183HU64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015379">
        <property type="protein sequence ID" value="VDO73182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU64"/>
    <dbReference type="STRING" id="387005.A0A183HU64"/>
    <dbReference type="WBParaSite" id="OFLC_0001102601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001102601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001102601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001102601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9529" checksum="B85B9D357E42B95C" modified="2016-09-07" version="1">MKADVMQGIVHALAYNFQIVNMAVSCPSPVMIADRMAKRGRCNYVAMFGDESENSDNGSGIEKDLIQLNNQLSYISKPLETVRFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUA0</accession>
    <name>A0A183HUA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11057</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015474">
        <property type="protein sequence ID" value="VDO73464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUA0"/>
    <dbReference type="STRING" id="387005.A0A183HUA0"/>
    <dbReference type="WBParaSite" id="OFLC_0001106201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001106201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001106201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF28">
        <property type="entry name" value="ZINC FINGER PROTEIN 37-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO73464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001106201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19855" checksum="8C3F5DF7EF30881F" modified="2016-09-07" version="1">MVLSDASNTSIILHRKSTNSTPGQHANSVPNHSPNAPEESHTACSKMSTSNSSMLISSMDSSDIDTGISVTSNGMVKQTQPIKLNEAEKANGYNTVDATVKDQKWSTSMQPTVTSASSINAAAVSTALPCAICGQSFPDAFALQRHWLSHVCDRPHICKQCDAGFTTADALDIHTLTHQNNRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW14</accession>
    <name>A0A183HW14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11674</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017162">
        <property type="protein sequence ID" value="VDO78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW14"/>
    <dbReference type="STRING" id="387005.A0A183HW14"/>
    <dbReference type="WBParaSite" id="OFLC_0001167601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001167601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001167601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="2">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001167601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11588" checksum="3856B2634FF1E3D2" modified="2016-09-07" version="1">MQKEQIDTDVAQNGEKEIEEAKDMMESDTEEALLEPRFKYSRILNNVPEILRKDMATCMAIHDKFAAVGSRSGTVYIFDHFGSLHPENVRFDSFLPYLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW17</accession>
    <name>A0A183HW17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11685</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017194">
        <property type="protein sequence ID" value="VDO78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW17"/>
    <dbReference type="STRING" id="387005.A0A183HW17"/>
    <dbReference type="WBParaSite" id="OFLC_0001167901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001167901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001167901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001167901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14179" checksum="2238064A5E06E948" modified="2016-09-07" version="1">MARASVLTFLDSHCECNVNWLEPLLARVNENYRAVVAPVIDVIDRDTFKYVAASADLRGGFEWNLVFKWEYLTGKLRNERHARPTAPIKTPVIAGGLFMIQKDWFEKLGTYDEEMDVWGGENLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW36</accession>
    <name>A0A183HW36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS11697</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017235">
        <property type="protein sequence ID" value="VDO78516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW36"/>
    <dbReference type="STRING" id="387005.A0A183HW36"/>
    <dbReference type="WBParaSite" id="OFLC_0001169801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001169801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001169801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF295">
        <property type="entry name" value="SODIUM: NEUROTRANSMITTER SYMPORTER FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO78516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001169801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11602" checksum="0B8EF7FC383AC90C" modified="2016-09-07" version="1">MWFEERSWSNLKMSSMLVEEWRDLWSIKIDMIVASLAYVFATTNFLNLPELILRNGGLAFVAAYIASLLICVLPVIVMEFSVGQLVGRAPIKALYNICPLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWG9</accession>
    <name>A0A183HWG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11833</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017619">
        <property type="protein sequence ID" value="VDO79594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWG9"/>
    <dbReference type="STRING" id="387005.A0A183HWG9"/>
    <dbReference type="WBParaSite" id="OFLC_0001183101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001183101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001183101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO79594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001183101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15307" checksum="3EEB0161AEC72D16" modified="2016-09-07" version="1">YNNKIIIGWRGPQCNLPCWAGHGNADCKPCNCKNDAGCDPLTGECICTPGWTGKSCEKPCSKNFYGINCSQECQCKNGAVCDPVNGECICAEGWIGSDCSVSCPSGEKKDCLGSCPCVHGTCAGGFEKCDCQPGYTGHICDKGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWU2</accession>
    <name>A0A183HWU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11957</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017927">
        <property type="protein sequence ID" value="VDO80721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWU2"/>
    <dbReference type="STRING" id="387005.A0A183HWU2"/>
    <dbReference type="WBParaSite" id="OFLC_0001195401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001195401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001195401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO80721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001195401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="6802" checksum="B90CAE477C3B2382" modified="2016-09-07" version="1">MPGIDGPPGPIGKRGLPGENGLPGNRGSPGLPGPIGKVGPDGNNGVCPTYCATDGGVFFVKPPEWFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWV3</accession>
    <name>A0A183HWV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11967</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017947">
        <property type="protein sequence ID" value="VDO80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWV3"/>
    <dbReference type="STRING" id="387005.A0A183HWV3"/>
    <dbReference type="WBParaSite" id="OFLC_0001196501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001196501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001196501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001196501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9021" checksum="E06A0A8D9CEB89A8" modified="2016-09-07" version="1">MRKGKISKRMILEQKVLLRLQGRTHVPLLWGSGSTKRINYIIMQLLSQNVNDIRKQSPFKRFSCSTMARIVIQVNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXS9</accession>
    <name>A0A183HXS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018888">
        <property type="protein sequence ID" value="VDO83543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXS9"/>
    <dbReference type="WBParaSite" id="OFLC_0001229201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001229201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001229201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001229201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9901" checksum="62722F361553EE29" modified="2016-09-07" version="1">MRSSQSKEPLSPTSIPSVAPSMQPKPIPKLSTLPSLSETAVETPSLFFNQISVKRRQNPWQQVDHEPSDFSYELESDSVNDSIYLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYN4</accession>
    <name>A0A183HYN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABCA8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039878">
        <property type="protein sequence ID" value="VDP11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYN4"/>
    <dbReference type="STRING" id="387005.A0A183HYN4"/>
    <dbReference type="WBParaSite" id="OFLC_0001259701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001259701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001259701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF260">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABCA1-4-like C-terminal R2 regulatory" evidence="1">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001259701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18342" checksum="19E4E3E9C818F07F" modified="2016-09-07" version="1">MDPSAQRFMWNVLLKLRKNKRAMVITSHSMEECEVLCNRVAIMNRGQLQCVGPIQHLKHRFGEGYTLTIRLSTNESISKVQSSMENLLPAARLEAVHFRTMFYQIPNASCTISDTYDVICKMQEFTDIDDYSLSQTTLDDMFVSFVSVSSDETGKTSPNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYR4</accession>
    <name>A0A183HYR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12626</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039886">
        <property type="protein sequence ID" value="VDP11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYR4"/>
    <dbReference type="STRING" id="387005.A0A183HYR4"/>
    <dbReference type="WBParaSite" id="OFLC_0001262701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001262701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001262701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001262701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12257" checksum="5C4AE8BFD8E328B0" modified="2016-09-07" version="1">MEDTPAIEKAKNTNLVCNENIAHRKSPELFPENVPGAWDMNRTLTTAAGDFRSSRFRTELDTQDVRLVNELGQFSADQLMEYVRNLQNSAYTLGIEEGYFVLCFFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZL7</accession>
    <name>A0A183HZL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS12929</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039980">
        <property type="protein sequence ID" value="VDP12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZL7"/>
    <dbReference type="WBParaSite" id="OFLC_0001293001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001293001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001293001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2034"/>
            <end position="2087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001293001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2198" mass="254662" checksum="71EA948631F9891F" modified="2016-09-07" version="1">MEGHWQRAKGVIAAGERLVATGQNKEDIQTRIYNLHAKWEQLRKVVEAVGRWLREAEQAHQYFQDANEAESWIREKLPLVKSSDYGRDEQASESLLSRHLRLEEEIQSYRADIIRLEEMARELANTEFIAGAVVRIEEDTEELIVPQVKMLYAYAGNNIEVKKDEILALIEKSNNDWWRVLKQDGIEGYVPANYCKIVEGETVTVAQTITTRKTEREPQGSRNAIMERQEAISAGYRNLNNLAEERRRLLNDVIKLYKFLRECDQFETWAKETKTALTDSTTSDNVKASRKKFNKLENEISANGKMQIERINNVAEELVNEGHSHSDEIRRRQDVANLIWNKIRDLLKTKQRQLEAAERVAAFNETCEDARSWMQDKFDLLEHKVDMNDPKAVQAMQKRYQNLGKDLKPLEEKICILQQLADEVKKEHPGEATKIEQMIRELVLMHDELRQKSAARIEEAEQTQGHQMFNGAVKNLQTWIDKTKSTLVDNTRPVDVSSAEELLKKHYELNDDISGKKYEFDYVRDLGQRLLQKNSALNDVKGSLKKLDTEQQTLNALWKEKERWLKELLNLQLLNTEAERIDAATKGHEAFLELSSLGDSVETAENLLKRHSDFEAKLRAQEDRLKVFARSADQMIQAGHSEADFIKKRRDDVLTRRSLVHQAASKRRAQLEASLQYQNLRRNIQELTQWIAEKKRIANDGSYRDAASITMKLLKHKAFEAELKANAARLDELNAEGNALIAARHYESKSIQKLLSNVNAEWADLLHAANAKGECLRQAEDQKGLNSALDDAHLKLDEIQASLNSKDLGSDLRGVKELIYKHVVVEKEMIVFEKRTFEMTEKANVMIQQGHFDSIAIKKAVQKLAERFESLKKPAKDRRTALEESLKWHQLSFDIDCEMHWISEKVPIASSEETGRSLTEATNMQKKYEQLEAEVASRLPHIKQTLNRGNDLIKEKHYAQEQIRSKYEQLAEALTYLNNLMQKRKNLLDWALKEEQYMFDAAEVDSWMNEKRGALTSEDYGQDEDAAQKLLAKHKALQADMVTYKQWLQKLAVQCKELENSNRSNSERFVTRQVELEKEFEMLSNLADERRQQLENAVYLYQYLRESQDLEAWINEQLLVAMSEDYGIDYEHLKELQSRFEDFKQSVKTGSERFVHCESAANALLRRNPPFGRDILKRQEKLRSVWSLLLDYIESRDQKLEAAEELHRFNRDVAENQERIAERQASIPAELGKDIKQVHSLWLKHEAFENQLGAMEQQLRDLLEESARLKASYPGGNAEHITAQQAALAEAWQDLQDATVLRRDMLKAAYDFQRFYVNARDLIAWTEVIVRDMQSKQTVHDLQNAEWLQKEHLRLQIDHALKRVRDEWTIRREWLSQVEAALAQLRVQMNVRKSILNDALNLARFNSDMMEIESWIDDKQKRINAESDRQAKLTSIEDKMKRLQKHQAMEAELSTNEYRIQEIRVRAQTLASKPTNDGHDINKRTAAMLNKWNELEAMSRDQSSALEEARDLLDFKQLVERVMRWIKDRELLVSAGKMGRDMEHCQALLEKLDGTQADASVDQTSVESANCLGQKLIAQGRSSKDEVQQQLKELNDAWTQVQVKLSLYRSQLRSALEVHAFNRDVDDTCERIQEKLTAVTNDDLGKDLHSVEALIRKQEAVERDMTAHDIEAQKLLDKKPPLCNTVIESLQKLENSWKQLAERATDRGHALMASGELHKFLDAMRKAEIWAVDALSRLTTQEAPRSVADADASIARHVEKLAEIDGRQREMSELREWSTKLIAKQSDHKGEIQRALKRLQNVEHQLRQAWEARNIALARARNRQLFADQAARAEQWLASKEAFLKQADMGESVVSVDVLLKKHCDFEKTLIAQSDKIDALKKDADSLALGDADYRSEIEKIRNTVLSRHAALMDSCKRRHELLNESRKLHEFIDSCGELMTWINANIQLAYDESFLDQTNLRAKLQKHLTFDAELEANEGRVKLMIEAGNKFIASKHYAADRITLQIAEVKRGWDELRNKSIMKKRRLWEANEAYQLNRRIEDLEKWLERVENDLSSEDHGKDYISVEALIKKQDDLEAEIKSRKDAVHEIVSKAHEFQRQGYATANESLEMAIALEIRYNELKKPCIIRRENLNDALAFYGWISEAEEQIEWLSDRKRQTISTDYGDTLHAVQLLIKKHTHLETDINSRRVRFNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I086</accession>
    <name>A0A183I086_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13148</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040064">
        <property type="protein sequence ID" value="VDP13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I086"/>
    <dbReference type="STRING" id="387005.A0A183I086"/>
    <dbReference type="WBParaSite" id="OFLC_0001314901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001314901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001314901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="312"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001314901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="668" mass="76283" checksum="C2F7439891036A28" modified="2016-09-07" version="1">MLRILQGSSASRFERVLWLLHPVSGSSYRTLQCFCQIPHRIDGPNPRLLRIHEIEISKQNFPRNKGSLPNDGRKSRGSGFLILLLVVTAGVGASAYYWYFENEKKSKHKTDFLLKTATAPASTSKAPEQTVSHEKESISQRKQHETMEKMLKTSLQSAIAKVQSATEAKYRTVDIINEHTRVMKQAVDEGEKGDWMLVTDALQKVDKAAKNDAEEENDARNYLDNVRKIIEQGEIAEPTRSNPLLQNAHETIHKLERQLDEMNLVIKRTRDEGRILSEYKDLIEKSRKQFASELKSVLPNVDIHAQDSKLSEEELNALIAHAHLKVDQLRKQLAEQQFLIRLAREEQNIASALEEQKKSQSKLTEEEINLKVQALREEIHSESEKMLAMQRKLWEAELEEKLQRAAAAHSEHIEEVVRVQRNLFEIEEKQKIEEAIGEERSQLSTELAVAQGKLEGIETALKSRTSQDVENRRAKQIWMASHDLVDSVIHGRRSGADDDARRKPLATELQMIREANSSDEFVACLVNALPDETIYNGVYTEEDLKTRFNKLYKICRRVAKMDESNVGVFQYGLSYLQNAMSFDPPRKFSKMGKFDPMTLDSYEILSRAKSFVAEGDLNSAVRILQLLTGPARFVARDWINDVRAHLEARFIAELLVAHAAVNNYSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I095</accession>
    <name>A0A183I095_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13157</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040067">
        <property type="protein sequence ID" value="VDP13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I095"/>
    <dbReference type="WBParaSite" id="OFLC_0001315801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001315801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001315801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001315801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8463" checksum="212D3622B014812B" modified="2016-09-07" version="1">MRPLEKLNLSWDPVNLTVEKTALAGTKGFIVFLATTQIFEDELKTYTIYCIKSSNILKKFGENLEGFEFQIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0E9</accession>
    <name>A0A183I0E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13211</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040089">
        <property type="protein sequence ID" value="VDP13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0E9"/>
    <dbReference type="STRING" id="387005.A0A183I0E9"/>
    <dbReference type="WBParaSite" id="OFLC_0001321201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001321201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001321201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000442">
        <property type="entry name" value="Paralysed Arrest at Two-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000401">
        <property type="entry name" value="Troponin C 25D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001321201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18489" checksum="38A3FBCDD7C943EE" modified="2016-09-07" version="1">MAEDIDEILAEIDGSQIEEYQKFFDMFDRGKQGYIMATQIGQIMHAMEQDFDEKQLRKLVRKFDADGSGKLEFDEFCALVYTVANTVDKETLEKELREAFRLFDKEGNGYISRPTLKALLKEIADDLSDEQLEAAVDEIDEDGSGKIEFEEFWELMAGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0H4</accession>
    <name>A0A183I0H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13236</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040103">
        <property type="protein sequence ID" value="VDP13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0H4"/>
    <dbReference type="WBParaSite" id="OFLC_0001323701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001323701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001323701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001323701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43675" checksum="6AF79998DD930E33" modified="2016-09-07" version="1">MNETQRDLFGSARDLSEWLPVDWMCQNRCPERVIDDYTLPSVQYSLPSLLKLSTYSFNANMLCSNSGIKTVFRCLRFLYQQIAYNTAEITIIDLDRSLSYLTAFAQNMELDGDVETLYGIAREFKFFLIQAGSLSHYITSDGLFTTRNIETNYIFHALLITWMKAVRISSFFKRFDGFEKLYPVGDASSSTEQLSMLVSYGLLLSASRTDRPCICRCVTTAWHQLYVFNREMFWSNMVKLLGLCTGDIHYSPPESPSSDMFLDLCDVSGTVSAETFLEIICELGIGFDDTYISSGEKFRKINTKQRMFSKASCSYIECLQQIVLKVSEKKSTLSFQFYESQFFRKLYFLFCRHQGDSLLGTESILQHFFTYLCSNIMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2E2</accession>
    <name>A0A183I2E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS13904</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040460">
        <property type="protein sequence ID" value="VDP14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2E2"/>
    <dbReference type="STRING" id="387005.A0A183I2E2"/>
    <dbReference type="WBParaSite" id="OFLC_0001390501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001390501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001390501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051446">
        <property type="term" value="P:positive regulation of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000215">
        <property type="entry name" value="Cyclin-dependent kinase 2 (CDK2L)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDP14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001390501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36875" checksum="F63A5446A883163A" modified="2016-09-07" version="1">MDSREISALQNYSRIEKIGEGTYGVVYKGIDKRSGKMVAMKKIRLENEDEGVPATAIREISLLRELTHPNIVGLEEIILEENRLYLIFEFLHMDLKKYIDTIPDSELMDKTLQKSYLYQILQAICFCHQRRVLHRDLKPQNLLVDKNGAIKLADFGLARAIGIPIRAYTHEIVTLWYRAPEVLLGATRYSMGVDIWSIGCIAAEMATKAPLFQGDSEIDQIFRIFRIMSTPTEDIWHGVTQLPDFKMSFPQWKEDGLRKILDTYMDPEGIKILRDMLIYDPAQRISAKKLLKNPYFDDVDRKKLPAGDYDGTLVIPPRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Y8</accession>
    <name>A0A183I2Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14100</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040597">
        <property type="protein sequence ID" value="VDP15488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Y8"/>
    <dbReference type="WBParaSite" id="OFLC_0001410801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001410801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001410801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001410801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11839" checksum="2B64E69E3ABFFDED" modified="2016-09-07" version="1">MRQMSDSFPDKMEEIWIDHCIYTCVYICVKLMVADMLQSKCPHFASHYLYLIEVTFPQVVITPVRLMLRVMRMNVAIITIVDLSLPCASKPLSLRYIFSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3E0</accession>
    <name>A0A183I3E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane and coiled-coil domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS14252</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040713">
        <property type="protein sequence ID" value="VDP16184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3E0"/>
    <dbReference type="STRING" id="387005.A0A183I3E0"/>
    <dbReference type="WBParaSite" id="OFLC_0001426001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001426001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001426001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF14">
        <property type="entry name" value="DEMENTIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP16184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001426001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44858" checksum="8182765DF83F782B" modified="2016-09-07" version="1">MLAPITKHDPHPESDGSWLGSSFRSSDGCESHGGVDDAGLDERTRIERKIEQIKERLSRISLAREVDVDDFLSMTSSMEGGSENPQLTRVRQHFEKKNKKSSQEIEHLKKKLEQLQSKLVDLNMGIVTELSPKSAVLNNIRKTGPLLREVISAPRGIAHIIKSTFGSADNIPGSVESDVSNVGHSTFYSDTQNSDRIPKFDLEDCDVAPSPAKRGHKRNETLPSMVFDLDNLVTSSHTEISHHEPEVKFTTADIMVKVRNDIQELKAQNQILLEQLNKLQAQNKSEFNYFNNSLHEERIKAQRLEEILNETIELHQAEMIALKSDLSTIATRMDYQYSDRFRCIEENIESTQNKMIRMEVNVKEWTESRPQTTFSSVMLSGTNILVEFIKLVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3S3</accession>
    <name>A0A183I3S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma70_r2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14385</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040812">
        <property type="protein sequence ID" value="VDP16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3S3"/>
    <dbReference type="STRING" id="387005.A0A183I3S3"/>
    <dbReference type="WBParaSite" id="OFLC_0001439301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001439301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001439301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001439301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6405" checksum="AF48F1B944CA04DC" modified="2016-09-07" version="1">MDEQVEGAVRRIFDNMDEDAYEIARQFYCRLIDLRLIGALTLCLSTNIGNINLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4C8</accession>
    <name>A0A183I4C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AcidPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14590</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040980">
        <property type="protein sequence ID" value="VDP17762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4C8"/>
    <dbReference type="STRING" id="387005.A0A183I4C8"/>
    <dbReference type="WBParaSite" id="OFLC_0001459801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001459801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001459801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP17762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001459801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15699" checksum="EBE1C8CC128E465D" modified="2016-09-07" version="1">MVGELRPIFMDICNPLFDNTYCHDQAYITDYKCRGNKYNYAVKEARLSFFSGHASLAMTTAVFFVVYLQSRIPRKDLIIAKSLVQLFALGLGLFTGYTRVIDGKHHLHDVIAGYIVGALIGYITAKDIVELEVKSDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4J0</accession>
    <name>A0A183I4J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CLU_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14652</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041042">
        <property type="protein sequence ID" value="VDP18033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4J0"/>
    <dbReference type="STRING" id="387005.A0A183I4J0"/>
    <dbReference type="WBParaSite" id="OFLC_0001466301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001466301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001466301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clustered mitochondria protein N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP18033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001466301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17287" checksum="202B9C2562AB5D03" modified="2016-09-07" version="1">MGEDNGLVCSPEAVLASAAKTLSEDGQENSPHNSANDSGHETSSPDSPLTPVEEETVPTVAEKTGNDDEAICPSDDCDATFRIRIIAPGAEPFDLQVSSGEMVQELHQVLLEREATCHRTCFSLQLNGVSLDHFTELKNVAGLTDGSVLRVVEGKDMASSVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Z4</accession>
    <name>A0A183I4Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14806</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041224">
        <property type="protein sequence ID" value="VDP18899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4Z4"/>
    <dbReference type="WBParaSite" id="OFLC_0001481701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001481701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001481701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP18899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001481701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22570" checksum="045D5CFB9205A2B1" modified="2016-09-07" version="1">ILDKCRNRINCYNGGYNDPNNCGRCKCPTGFGGIDCLSVQKSRTTNCGGDLIADDSDQIITSTGLYGHVHCVWRITSKAQVAVFVSELRLPCEYETCTNYXXXXPYLHCCGPSQTWITSENNTLIVIYSTEDYSPGSWGFTPPPLPEKAITTPPTTTTTKLITTTKETSMWSEWGKWSLCSTTCGGCGKQRRVRACYGQDRNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I561</accession>
    <name>A0A183I561_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone deacetylase complex subunit SAP18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14873</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041310">
        <property type="protein sequence ID" value="VDP19366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I561"/>
    <dbReference type="STRING" id="387005.A0A183I561"/>
    <dbReference type="WBParaSite" id="OFLC_0001488401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001488401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001488401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001488401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="693" mass="79751" checksum="D68C33BEF079CF37" modified="2016-09-07" version="1">MKKSGKTRKTVSSSSSSLSSSSEESSDDSSESSSDSDNSSSDSVEESSSDSSSESNSSEISKAKIRKKVKDIPHNERNLLDKGEDSKADRERHLRRDPPNYYDRSYRHKRHNNDHVGSRRFGRSYDHNGGGRRDWCTRRYDHRDDLHRRNDAGSDRRRKHDHNEKRYHQEKEKRSHRKHHDSSDSDTDRRHKHDEADRNDKEDRKQLRQRSSSVEEKKDSRSKLRENILDTKEIKEEPALSPNSVFEESSRSTRNKTPVSQSNTGEITLPEKQIMEGVKMDIDVQKSKTKINSSDEDEVKRSSDRKRSRCHSSEIGDNSEKRYRHDTPESEDGTESNSSSNDEFLHHSDSARSSTTTSNGSAAEHIFNENSDEICSPSHSPKGTPEIKERSKRLGSRERKTHSPENKHERSNSNKSTRKHKSCKDSKDGNNYRGHGSRGSFSESLNRNLSRVESDHDNSESDKRNYCRSDNFRKYKKHYTKSSESNSRRSGSDESRHHGHHRLTSSDRIHRLSRRKSHSNDSIKRKRHDKSRSRSHSKRQVTRSRSPSRRHHKHSENQLISSHQDIHKAASVLSRKRSYSPKNSSTKRFTSTSESKKSENSKSVESSESVESTSEEEEHSKRRRHDSSTSEDDDEDTEGLNSKRSRRSSGSSSSSSNSSQSSKTRTGQKSNDYGKKRHQQHASILREPVDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5L1</accession>
    <name>A0A183I5L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Condensin complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15023</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041498">
        <property type="protein sequence ID" value="VDP20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5L1"/>
    <dbReference type="STRING" id="387005.A0A183I5L1"/>
    <dbReference type="WBParaSite" id="OFLC_0001503401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001503401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001503401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001503401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27134" checksum="236A38DDDF97106C" modified="2016-09-07" version="1">MDSNIRETSARAVAADFLMRLRKKGGDENRLKVARQLYDYINGELRDNSEQFTAEFFATFDAKVDQSAIHTLMTSPDNDERKAGIILIACLVENAGDETKRVPRFAKYLLKALVQGDEAGMKLVARAIAYLIQTSKTFAAELVEKSINQVCEWLEESERHESRRLAAVFLARQLALYTSTSFFLRASNFFSNIFKVIRDPKTTVRIAATKALHAALTVTSQREARQKSEWYWVSYFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I684</accession>
    <name>A0A183I684_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate kinase</fullName>
            <ecNumber evidence="4">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS15246</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:18159"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01041824">
        <property type="protein sequence ID" value="VDP20994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I684"/>
    <dbReference type="STRING" id="387005.A0A183I684"/>
    <dbReference type="WBParaSite" id="OFLC_0001525701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001525701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001525701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP20994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001525701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20206" checksum="DD29852342CA4F6B" modified="2016-09-07" version="1">MNTFYRQKQKLASASESTNLEHLCNLNIHEEPLLIRKTGIICTIGPACRSVEKLQEMIINGLNIARMNFSHGSYEYHAETIANVRAAAHSFSEPRLVAIALDTKGPEIRTGLLEGGASAEVELRKGSRIRLTTDPSMETLGTAENIFVDYKNITKVLSIGSRVFIDDGLISLIVNSVGKLSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6N6</accession>
    <name>A0A183I6N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15399</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042067">
        <property type="protein sequence ID" value="VDP21679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6N6"/>
    <dbReference type="STRING" id="387005.A0A183I6N6"/>
    <dbReference type="WBParaSite" id="OFLC_0001540901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001540901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001540901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP21679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001540901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14301" checksum="E3CBFFCD34974CA2" modified="2016-09-07" version="1">MIIEAISTTLHISSKTDENIEKPKKVHLIIRAKSEERKSIRISDTKNEADLESSKNVDPTIWMDPCPEFDYDARNYGDPFQVPEYAMDIFNYYHQREAKQKKIFFFSLNLFFFLFLNLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6Z6</accession>
    <name>A0A183I6Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15508</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042274">
        <property type="protein sequence ID" value="VDP22262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6Z6"/>
    <dbReference type="STRING" id="387005.A0A183I6Z6"/>
    <dbReference type="WBParaSite" id="OFLC_0001551901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001551901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001551901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP22262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001551901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32543" checksum="CCC3AEAF4FF48DA8" modified="2016-09-07" version="1">MVIIHSPNIKSVHFIDRYLTPRMPWHDIHACTYGTSARDIARHFIQRWNATKTEKSKELKEYPFLLPKSYDTVKVPRVLETYSNLADVQVLRSVSKWSSLTNSTEDSIQQAYVSLIANAQHYIYIENQFFVSIIDSDDVRNEICKVLCERIKRAYRDHAKFRVYIMLPLLPGFEGEIGAPGGSALQAVLHWTYKSLSRGPDSLIESLKRYIPDPMEYIHIGSLRTYETLSGKLVRMKFLLTKKKKEKKTLCCPPNRFMFHIFEKKKKILPIIFPNEWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V044</accession>
    <name>A0A3P7V044_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS1028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000437">
        <property type="protein sequence ID" value="VDO27947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7V044"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF490">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO27947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="460" mass="52178" checksum="99C73A5D1C290907" modified="2019-02-13" version="1">MNPSVKCCDFADKSNSTAKSTKIDYNSLWLPRPFRIICCLGGYPIPENPQIIRNWTHEESDYINDERYGEHIISSSAGSRTRGTAKEKGTDSKCRMYHGSYFLSASAIFTFDDFSGIGVTCKCPEVPPHEYLDRSCRRLKPCINNGHRSFSSNSECICPEPYFGEQCEKYCDQGQRMRDANGRDYCACTPFYQGEECRNIVCLNGGTEIRRQCLCPPNFLGYHCEIDANRTSVMLQFHGYREQNFYQDNDFLSRDVSSTLFSLVMIAILILSMYLLMKHRMQVQNRFATVRREALVRSGIEITARRGNVIVPEDPRILSFRSVTFPNEGPPPYIINSHSGGPCQRDNLPPLPTYEDATKLPPFIRQVPSSQVEGETGTGEEEQMIRNDASSSELQINERMRETDSNDELSIVCSSTYPPEPRHLSETTTSVSDRVSVSMHVFTTDNSSVFSKKLLARKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WSV8</accession>
    <name>A0A3P7WSV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007475">
        <property type="protein sequence ID" value="VDO50167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WSV8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="207" mass="23228" checksum="4A1D487FF8009E88" modified="2019-02-13" version="1">MFFKNWLHFFCYTDVNEEVFPLAKKKKKSESPPILRKPRPLSEILAKVRAERDSTFVPRNIKLKQENGKSFGESTADVVGHAIPKTDGGRHDNVEYGPRPLEALGTQPISDDEDELQLSPLKIKQTEASKSIKIATISKVLFDSEKKAQIGKDGEIPVSDASAGPSFSNDDTIDEMITEKHLRSERGMSGNESEKRRKTDGEFETSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WUF7</accession>
    <name>A0A3P7WUF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007802">
        <property type="protein sequence ID" value="VDO51094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HIZ7"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="124" mass="14197" checksum="1B706F4FFD39845A" modified="2026-01-28" version="1">MKLLTHNFLSSFFLKGVTEGYPLILTATKKEIKEHEYNDSFVQRMIPKLNYGAFREAALSIGEGEKLPEQLPEKLEDEELKNELHRLLVCVEIIDGELKCPESGRIFPIREGIPNMLANPNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7X0L8</accession>
    <name>A0A3P7X0L8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006846">
        <property type="protein sequence ID" value="VDO48313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7X0L8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="211" mass="25046" checksum="78D7ADCDE1F38471" modified="2019-02-13" version="1">MDNISVVYRNIKSPLGVNGKYRANFISLNELNLQDYTVAFYLRQFWRDNRLAFESAEERELTIGIDLIKSIWVPDTFFPNEKKSFFHEATTHNSFLRIDNRGNVFRSISLSNNNNNLVSHIKWKYQNNHLKTRNVAYQAEYQMLPEVEPIQMIYFPLDIQVCALEIEVHSLFPLFISTFDKQKMICSGPNLHFTFFYTHSIVTKFYLFYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YS71</accession>
    <name>A0A3P7YS71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005037">
        <property type="protein sequence ID" value="VDO44008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HDY4"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF18">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="164" mass="18928" checksum="42564EF69CF5AE5F" modified="2026-01-28" version="1">MLLARTGRLNLARCYAAGAEFLKDVPLIKRDGEIVKTNDLKNKAIILYFSSGWCGHCRLFTPKLKKWYNEAAKDENIEIVWVSRDREAQHQLDYYNKALPNVPYIPFGDKHISEFLKKYDVKTIPAAKLVNSKGEVIDQEVRNKIQDEGEVDAKKLAKEFRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A914</accession>
    <name>A0A3P8A914_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS8920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010482">
        <property type="protein sequence ID" value="VDO58025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8A914"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SNF2 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO58025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="266" mass="30113" checksum="EF2EBFEC07F389C8" modified="2019-02-13" version="1">MSLIGFFIIQKKALRVILLTGTPALSRPVELFSQIRIIDPKMFPNYRDFAFRYCDGKQGKYSFEAKGCTNSDELAIILTGSVMLRRLKKDVLDDLPVKRREVVNLTDDSIYTNISKLREAKNAYSGAKDNNTKHQRLVEYYYETGIAKAKSVARYIIDHYFYDGAPKRKLLIFAHHQVVLDMISMDIAKKGLRSIRIDGATASRSRDEQCRLFQENDDVMVAILSITAAGIGVTLTAASIVIFAELHWNPGVSTIVNIDFYCEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AHC9</accession>
    <name>A0A3P8AHC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040192">
        <property type="protein sequence ID" value="VDP13717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825430at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="136" mass="15932" checksum="230547744A52645C" modified="2026-01-28" version="1">MYCSLTAICTFVFLPALLLESFFLTKVSSLRHFEHNSDKPTPRIQWVPVVQRNFTKMSYEHDDREIPYQSMEMDNIRQWKWKMGNEKTRTFKQQVQKGIAENTTKSSIAAKSASFISQTHLLFAIWPFTVSFCAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CVU9</accession>
    <name>A0A3P8CVU9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042540">
        <property type="protein sequence ID" value="VDP23045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CVU9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="19104" checksum="DE2F1613C9E98A90" modified="2019-02-13" version="1">MNYYFSEASDQPTCSRSLPTRTREDGSADIIGHLQSISQKIFFNKIKSKMLEDLTLLKKDVQMVKPTFKLEAHWSNIVHNSDKLSMQACDQQEAIWEFITTEHQYLQANEIFLLKQMNEFRQYFLKLQEAGHMRDIDSRRIFLNYSELYAHHSKFWENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXQ7</accession>
    <name>A0A183GXQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS17</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000005">
        <property type="protein sequence ID" value="VDO24215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXQ7"/>
    <dbReference type="STRING" id="387005.A0A183GXQ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000001601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000001601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000001601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF164">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO24215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000001601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22511" checksum="69A7B6D0598DD56E" modified="2016-09-07" version="1">MEEIEPYVRRKRINPGKSNKLQGLNEEEQAVLRMSINSRERKRMHDLNDALDELRQCLPYSHRTGSRKMSKINTLLLASNWQVIKHLTNANNELRQKLDELRSNNRSNATTVLQATSTSAHHLGSPSTLAPLELFRPSPPSLSFKLTPETAQPILRLSVPVSLPVPAPVQPCIKSTNGLCFCINCLIANTGLTRNLRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYX6</accession>
    <name>A0A183GYX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS436</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000142">
        <property type="protein sequence ID" value="VDO25790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYX6"/>
    <dbReference type="STRING" id="387005.A0A183GYX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000043501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000043501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000043501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="571"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO25790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000043501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="717" mass="81205" checksum="17AC7E206440F6CE" modified="2016-09-07" version="1">MEDFNDLSDFKHFLLYSGIVICGTFEFEFQAKRRRKKTSVGKLEKSVSLTRRFHNLPKIPNIPDAKHRRQQTGEIETNFDPCKITQLCQNGGTCVSKKGAYYCQCLPTHYGKTCEFLADQTSCKENLCQNDATCYSIQQKRQIVSITRKDEAVENFTDTKVIKWIQYECWCRQGFTGSLCEYSEELRECEQDYCLHKGVGKFVNRTDGTAECDCHCQEHHAGKRCEIVLPCRDYTCYNGGICVNELMLNHTDGELTYAARCECPPRNVHGVAATFEGEHCERLIVTGNERIYDECFPCRKNAKDYAADCLDEYSQKTTLQYMEEILQACGKPCESAARFCLNGGLCDVEGHLGEDNTTSYMIPVCQCVGLDEGILCEKHVNSPCDASTYDSRTPAPCMNRRTVLHVRSLPGSSRSCFDGWTGEKCDIEEPCYNNACSPGSLCVAVPIEQREKYSLGYTCLCEINQDPDFTGPNNSTFTSCILARIIPVALRCEEQGRRRVGCISFYLISAVKCIKTDFGICTQQMCKNDGLCYPCEATDLNNLQLCSDEEKRRGFRCLCPHGLLPPFCEKEANACDQHKCQNGAECVVDSENEFNYICRCRVGFTGSFCEQQLSPCIMKGLQTCVMGSCVQDISFVRGFRCECLDGYEGVDCDLPKRTDVVGFIRRNYWWTYPLIVGLILSPVVITLIILSEDRAKREYEYKLAEKQYLEVSNSFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ36</accession>
    <name>A0A183GZ36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS496</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000167">
        <property type="protein sequence ID" value="VDO25992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ36"/>
    <dbReference type="WBParaSite" id="OFLC_0000049501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000049501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000049501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029153">
        <property type="entry name" value="CPG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF4">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15481">
        <property type="entry name" value="CPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chondroitin proteoglycan 4" evidence="1">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO25992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000049501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29972" checksum="7DAF8C4081E6973B" modified="2016-09-07" version="1">MKGFLSGDCVEPCISEMQLIMESTPFGRSDHQGQLSWTQLSQASKNRRVTENSFHNICEAYKRIDKCLEDCEKASEYSTSFRQTYAGLHFICIEQKEEFFNNLPCLAQYEPVAMSRCQKQINQSLVASNSFSAAVINREQHNIQNKLGTLCRDLANMIKCIEPITRNGCGEDAAKMMLKFITIGFTSFEQLYNHLGITDQLPYTCRQLLNLTIESRINNEKWLIFSSSQARNPHPENVMDSDHASHAIPSVIFPLLSISFCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ71</accession>
    <name>A0A183GZ71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS531</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000185">
        <property type="protein sequence ID" value="VDO26112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ71"/>
    <dbReference type="WBParaSite" id="OFLC_0000053001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000053001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000053001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000053001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10318" checksum="675A261CD9619683" modified="2016-09-07" version="1">MEQKSEEEVLRESNEVAQIEKGYRLVDSFKEKKGNKIIEVEGKQSTKKQQNFIRCLFRRIFIELPQGTKLQRNASNSYIIMFIVHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ76</accession>
    <name>A0A183GZ76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS536</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000186">
        <property type="protein sequence ID" value="VDO26122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ76"/>
    <dbReference type="WBParaSite" id="OFLC_0000053501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000053501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000053501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000053501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12091" checksum="976DBF00229C8016" modified="2016-09-07" version="1">SIHPSIHSATLHNTPTIGGGGGGGGSIYDEEKMNWTDSDLNRSIRRATVSEGRDRTRMGHPCRYVALLPVLIIIMCCHCQPLNLCIKLSGDGDIAPFVTITVILMEVAVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H020</accession>
    <name>A0A183H020_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS827</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000329">
        <property type="protein sequence ID" value="VDO27237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H020"/>
    <dbReference type="STRING" id="387005.A0A183H020"/>
    <dbReference type="WBParaSite" id="OFLC_0000082901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000082901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000082901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="32"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO27237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000082901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55807" checksum="7F9325238F4C2A77" modified="2016-09-07" version="1">MTRGKTLPTVGSFEVIESGKSMNERHRNEQGLGWIITSFFVVGDLAGGGIVALPAAFVQTNFWSGLIMNIVMALSMTYTAHMLGLSWTILQRRWPEYREHCRKPYPEMGGRAMGNTIKHIVSVCIDITQFGIAVVYLILSAKNISDFIDAFFKIEVSFCYVILIVGICLLPVTFLKSPQDFWWAIILAMVTTTLALILVMIGAVMDYSTCAPEIAFNEKVVPTNYFLALGTTLFSYGGHAAFPTILHDMRKPYHFTRSSILAFAIVFMLYTPVCILAYLTYGNSLRESILNSVQNTALQQGANFLITLHCILTLTIVFNPLNQEAEEVFSVPHHFCWQRVLVRTGMMLTVVFVAESLPSFGPLLGLVGSSTLTLSSLIFPCLFYLYLTVSDQIAEEKGKKMPDEIPSFVEVLVRSPRRRLIICSLIIIFGLIGGGMATYTSIKELATTRFTEPCYIKPFLSSSESKSIEGYLNCCGAWQNITRQGDISDCNPYVDFYSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0J8</accession>
    <name>A0A183H0J8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS1008</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000423">
        <property type="protein sequence ID" value="VDO27869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0J8"/>
    <dbReference type="STRING" id="387005.A0A183H0J8"/>
    <dbReference type="WBParaSite" id="OFLC_0000100701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000100701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000100701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="15">
        <location>
            <begin position="231"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="429"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO27869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000100701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="600" mass="68361" checksum="C3603FBE05EC4487" modified="2016-09-07" version="1">MDESRQICNRWWKQLLEHNFIKFDGLKTDPERFVDFTEVLESFDQGLAAKFYINSIFYVTVLSMGTNRHYHILEKCMNNEIVGCFCLTEVSHGSDANSIRTECHYDKGQFVMHTPDDEAIKCWAGNLGMNATHAIVFAQLYVNHTCHGLHAFCIQIRHLKRMVPLEGITIGDMGEKLGAWNGIDNGWIKFNKYRFHLDALLNRTATVHPDGTYQSAIKNIKEQQLASLAILSIGRAAIVGKGAVAARLAAVIATRYSAVRKQFRFATEERSIIEYPMQQHQLFPHIAASVALTIFYRKFISITYKHFVRCCVEDEKLPHELMLSREIRILSCAAKVISTEEGVNALDDARLACGANGFLKSSRLNDLRDAFDPSRTFEGDNNILRQQVVYALLSLSEENFHNWNDSPLGSLEFLAITPEKFSAWKNDPLEDIAKAYVWLLHFLIATIKEEIKCKVNEGFDERQARMEAQSEQYTMITYAYCELTMLNFFRESLQIASENICEVLRRLATVYAYSSIDKHIATLYIGGYCICEEWGNTVKKRLRESEAMILSDAVSVCDALAPPDFILHSILGSSDGQVYQRLIQYFMQISVKVSSDNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H161</accession>
    <name>A0A183H161_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1221</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000542">
        <property type="protein sequence ID" value="VDO28722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H161"/>
    <dbReference type="WBParaSite" id="OFLC_0000122001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000122001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000122001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000002">
        <property type="entry name" value="WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="949"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="1380"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1657"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1674"/>
            <end position="1683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000122001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1683" mass="186530" checksum="A3690B9FCE7F86EC" modified="2016-09-07" version="1">DAGPCKNFIERWFFDISSGLCQSFQYGGCAGNRNHFFSEHECEIHCARFFNGRTGRRRIAAYQNASHAQHNTLTWSQSNETLNENEHENSTSNDVNGQIISASKPEIISTQQGDNRWTDNRLISLDEMNTDTETDHTRDLIGQQKQSSIVNQKIDNSQTRQQNELSQEKSSSEKLLGHDRKLFQHENIEDIASLTTNIFDSKTAKQMLTDLAAVQNSQTSNDEQLVKLPQAEKSESQITSMMANDDKNKLTTGMEKAITEKTQTSNGASDNLLHDNQKISIDRNSGKLIAKELSMDSTSPRFESKNTIQLNSLNEFYEKKHKHLTDKVTNHMQFGEANSQSNNHFSHNAITDAANTGPTQLNRVPHNKILENENFNGARVAHLQHAAGENTAPSSAEEFPHDPMTMHTYTRSHEDQTGIETELPMKLSSFGSITDNANDNNNAGIVNQEESNLSPTMSSMEWNNDSDEYRIIDKMDISLEITPSHESLTSTIIPITTESDAIRPSESVMEKIVDPSIASASKILSTSDAALTVIPETTSINHSLLSSATIMPANINIMSTPSETIAKSDLISSQIAVPGSAIIENDIEGSLEPSIQTSPQILDQPIPSDKLWLYNGLQSLINSQSPTEQHSQQAESSEKELSFDSFDPADKLAPTTFSTTTINIDSVSAKKPSMLTDNLANSAQKLAGMNATVGGVKLQTIRRIGQPEKFKKIEETPHFNVDPLVFKNAYKSQNKSCTVILISRNGSNSINMTEELKHNLNATEEMENVRGEGIAGIMDDTTIHDFNNVPINRAILEQLNADILHQIASESSTKEVPIPPVQPDPQPDMNLNQSDRLNIVEDHSLHSLKHQTMQQSVNLNEITEQQLTTAPYTQMAQSTTSWTTLEQGESEEMPRDRTNMNQAEMTESEMESNQQEFFDLQETEETTPHAIVHGVTSLQQLQLEQDDTCVLPPDAGTCREYVPRWFYNSQTGKCEQFSYGSCDGNSNNFLDRHACEAKCSQGDSIKSQFPERCTYKKDEGHSNGYYVKWYFNVRNLRCEQMVYQGQGGNSNQFETLNDCQAFCKPLSENVLGRDKTTKQIEHSPTTTSVAPVQQTFVPSREHENQKQAGSVIEAGNISESGFHAHTISENAPKASHRAVSEIASIDDKNMQRISSEQHPVSLNTSTESTLPFTPIQEISQILDIEKNETLTAEDSSESLQLTDVMNESDNLVAEKKISSAKIFTEKIRSKNNNANILEDVSRAPSCPNGLKPMQHADGRPMMCLPGRNQCSGNSLCYFNGVDFFCCPNAEDPYDEHIFGGYGGEEVKRGYKNVKKTPINANEMIVRKLRLKRQAQVFSSSPLTINKAARIDFEVPKHSLARASFSKVDSDVDVDQVNDSCMQDLDKGTCSEAHLRFFYDYKVGFCRLFYYTGCGGNENNFATEEECRQKCKDKIQSENAPPGSCPFGDPPFGDNAPVICGKDAGSFDCPKGYYCHMGPPNVCCLEKNLPGALERTLITKKDQKNVRFSPQYPGGNPPGYQDGEYQKAREVNAALAVPTDICPDGSNALLDDQTGQPLKCGSGYDGSFCPIGYYCSINSESNERLCCELGVLGVKIPPPPTVPPYFGMRRSNPGEVISRGSLPSDYVPENESGISNVAEPSEGHRSRLVLFGTKLATDVKPTSDSDTSEEEEYSSENLTSSILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1V6</accession>
    <name>A0A183H1V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein Hox-A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1466</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000696">
        <property type="protein sequence ID" value="VDO29642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1V6"/>
    <dbReference type="WBParaSite" id="OFLC_0000146501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000146501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000146501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000146501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8436" checksum="A318C49BD9E51C78" modified="2016-09-07" version="1">MDCSTSNTSRLENASFMDPKYIPGVKSEGIPLQPQPSTSISTSAVSTATYRDFFVPSAGATAYQHPMHSFFSGFAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H256</accession>
    <name>A0A183H256_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000764">
        <property type="protein sequence ID" value="VDO30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H256"/>
    <dbReference type="STRING" id="387005.A0A183H256"/>
    <dbReference type="WBParaSite" id="OFLC_0000156501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000156501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000156501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000156501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37413" checksum="680D4D76108D337C" modified="2016-09-07" version="1">ATHRKHHHHHHHHHHHHHHDTKKDQQDDKLTGTSEMAVDISPTVVERKGDSMMIGTGDDRRIDKNSKYIRLNNDGHPIIRQHPSKSGLQKLQNSAKHRITSRKDENLKSAVMQNDDLDTYKPSISQPQQSGSLCSGQNENDSYKDRYRRDYGSSSSGNFHRTHYNHTSYRDRTRSGRYEHYTYREHRREHTYYRDKGDRTSYWERSYTDAYRDHGDRDYRQEFRHVSGASNSTANTNSALWSGPPVGFSSHTTPSFVNGPTPSFTSLCPTPGLLDIKPLSSVVSESSCTSQKSFIRPPPVPPHLDRLGTIDPIISKTDRTTDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H346</accession>
    <name>A0A183H346_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001004">
        <property type="protein sequence ID" value="VDO31210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H346"/>
    <dbReference type="STRING" id="387005.A0A183H346"/>
    <dbReference type="WBParaSite" id="OFLC_0000190501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000190501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000190501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000190501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11358" checksum="EE667C673B09FC93" modified="2016-09-07" version="1">MLERSEDDDILEDDATTSILVPPPTYRVTVQIDYEEGEPFGIVFGKNLTIIDVKKDMRADGVLYPGDVIISINDVVVEDQTQFYDVNEQLMMSFIIAINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3X9</accession>
    <name>A0A183H3X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myb-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2191</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001207">
        <property type="protein sequence ID" value="VDO32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3X9"/>
    <dbReference type="STRING" id="387005.A0A183H3X9"/>
    <dbReference type="WBParaSite" id="OFLC_0000218801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000218801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000218801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000218801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56473" checksum="C2623504AFBB480A" modified="2016-09-07" version="1">MFPTSNPPFTTPNAQQNVNNSMNLAAALYLHPSLGIANQAYTQFYQQAQNQAQLTQQQQQQQQLQRQFEQLVVAQAAQNAHVHLQAIQQHQQQQHAYQNQQVQTQNQQKMQVAQQQAQLQQSQAQAVQIQRLNALRQSNQHMSHSHSIRGSMPNIVKSRQEIQTEVDARRRRSLIADFMVAPNPATFLDERRRSDSISSGVFGEMRKSETMGSEFSVIADETTERKKNSITDHLEAVEKEKKFVDNQITIIQRKKEQYESELAKISSDNTDNDKENDDTTEDIDSMSLVERIYAENRKKAFRTEAQMPAILAPSAATIPQYRNPWDSPLVQQTIERYKTVKPYLVKMLTEQRQNDLLAQKYQIEKYNMLYAEWLKKDESARDEKHREIFEKTFPELKKTREERERCGRVGLLSGEQLEQDEEYKRRRAAAVLPPMMMNSRMRNAPFYIDLNGVVVDALDDHNAHIEYFLGKWTDDEKQVRQISCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H426</accession>
    <name>A0A183H426_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2236</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001243">
        <property type="protein sequence ID" value="VDO32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H426"/>
    <dbReference type="STRING" id="387005.A0A183H426"/>
    <dbReference type="WBParaSite" id="OFLC_0000223501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000223501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000223501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF32">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000223501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36507" checksum="86D841DBC17009D9" modified="2016-09-07" version="1">MNVYYHYHDDSIDSAHSNSAESSRKNSNRFDEFRQFMKGRKNIEKASPCDQLTCSLLNESISRRKISLDRQVFEIKEWDEERDKVLSRRFSVPEKDYVILRQSRERQLHVVAAFDRHTDPYKQYMQSLLCYDLAPVHGSAVLIDGDLPCGFQMRKSLLALYQSGHDAAIVINSIAHNAIGMITVTDCLRAIDLILNIDSEIGDRPVRDFIKVYSKKKIVAATVNMSVWDTAKLFCLNHVHRIPIFQIDENDLFSDILYMLSLRRIFCETIVKLIEPSFSLAPHLKQRTLFDSGIGTWGNIVTVVLCCSQLHFQITLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5I2</accession>
    <name>A0A183H5I2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ins145_P3_rec domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001650">
        <property type="protein sequence ID" value="VDO34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5I2"/>
    <dbReference type="STRING" id="387005.A0A183H5I2"/>
    <dbReference type="WBParaSite" id="OFLC_0000274101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000274101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000274101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol 1,4,5-trisphosphate/ryanodine receptor" evidence="1">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000274101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8140" checksum="69B62C466B9C359B" modified="2016-09-07" version="1">MSIDAFHNTSLHIGDVISLYAKGRYRSVEDRSEERLSPRTGFLSTLGLVDDRCIVEIGNGTPDSPPKKFRGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5J8</accession>
    <name>A0A183H5J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2758</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001663">
        <property type="protein sequence ID" value="VDO34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5J8"/>
    <dbReference type="STRING" id="387005.A0A183H5J8"/>
    <dbReference type="WBParaSite" id="OFLC_0000275701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000275701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000275701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22426">
        <property type="entry name" value="ARGININE_SERINE-RICH COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22426:SF2">
        <property type="entry name" value="ARGININE_SERINE-RICH COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="2">
        <location>
            <begin position="228"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000275701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35371" checksum="F1AB84587E67F46D" modified="2016-09-07" version="1">MTDNSFRPLTAKEIRKHIERRSDDRQSQEKQKKRSDDDDDKNRSNDIVRKKCHDDDRFCDWKHGRERRGRSMERHSDNRHRSDKHGHGREVDSVVQGRSSGCGHSRERSRDRYSNKEKEDRPVHRGHYYKESGSKQHRSNKPSYERNRNIRKSRPSRHHSSEDDEDGNSDRPAWATKAVVKRAEEIQKRKLIWSKPEEKKELESDTVSSSVIGLRPSTTSTWNSILAASSSDSKQLDKFKRLMGMKKTDEEDQGETSKMDDNQVEAERKRQHELYSHLDHQYAVARSFTHLGRGQGLGFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6A8</accession>
    <name>A0A183H6A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3019</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001892">
        <property type="protein sequence ID" value="VDO34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6A8"/>
    <dbReference type="WBParaSite" id="OFLC_0000301801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000301801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000301801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057143">
        <property type="entry name" value="OB_DEPS-1_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24342">
        <property type="entry name" value="OB_DEPS-1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-granule-associated protein DEPS-1 second OB-fold" evidence="1">
        <location>
            <begin position="66"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000301801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49687" checksum="B486C3A713294D4D" modified="2016-09-07" version="1">MSKCAGLISHQADNGLLYVFVPGKHPDLVIDERKTSNDEQRLHVGDFISFIDVNGSVTSPKRMKKLFETRFSNNCLQVQVLVVFPPEEFCAVSNNKTLAWSPDFAFVSCSPDVVKRFCPNQIYMAWIERLVFILDSPAYYRVPRLIQKVADILVSWQIVDDIFDKCDEQNRQLISKAPWNDKKNNHYFRSIPCCPHRMQQKPFHNQRAITTSLKKYIDNYQGLVTEVNDSSAKVWSLAIPDSEVVFLFGAREGMKVGDWVQFNCAPSIRPYLNCYLHGKKFLIIEPVLPAKPFNNTVQVELMMTITVDNLKYYPTGEVTVETEMLGAVEFGSGRFRKNYYNRCLSLIVCKNRPSKQTGSVWQVFCVVIEGCVEFMQLSNSSINFPNTNGIPAKEFVSMKKDKCNAEVEIDDYPFNESKLQENLSSDLPGPSQKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7F8</accession>
    <name>A0A183H7F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3420</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002276">
        <property type="protein sequence ID" value="VDO36438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7F8"/>
    <dbReference type="WBParaSite" id="OFLC_0000341901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000341901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000341901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000341901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7071" checksum="0C188ACB13AD2FBE" modified="2016-09-07" version="1">MVFDFFFGIINVSVSNPYSASFLTCLRDTFGEFQILRIISIHSSENSHPSKLGTWSSGGVGDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7M1</accession>
    <name>A0A183H7M1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3484</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01002333">
        <property type="protein sequence ID" value="VDO36675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7M1"/>
    <dbReference type="STRING" id="387005.A0A183H7M1"/>
    <dbReference type="WBParaSite" id="OFLC_0000348201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000348201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000348201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14341">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000271">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048637">
        <property type="entry name" value="MELK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21594">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO36675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000348201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47299" checksum="2980DF3926600EC1" modified="2016-09-07" version="1">MMSIASSHNSGIEDNELVFTSSYAALEGLYALHDELGSGGFGKVRLATHLLTSQKVAIKIIDKFRIKKEDLPRVKTELDALMLLSHQNICRLYQCIDTPVKFFIVMEYCSGGEMFDYIVKKERLEESEARHFFRQLVQAIAYVHSMGFAHRDLKPENLLLTEDLQLKLIDFGLCAKPELGLCDFLHTCCGSPAYAAPELIQGLPYKGHQVDVWSMGVLLYTLLCGCLPFEDDSVQKLYAKIATGRYYEPDYLSPLSRDLLKSLLQVDPKKRITVSELIVHPWINKKYTHALKWKSVYDKNIVDEEVIRELASHFGRLFSEMEALVKEVSFQWKFDYLTATYRLLLQQKRRGMNFVLPVLKPRNGTASPKQIVLGSQTIHASLDNDLNNSGLDETDLMIAETDGIMPKANGAEKSFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H832</accession>
    <name>A0A183H832_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Forkhead box protein fkh-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Forkhead transcription factor family member fkh-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3645</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor. Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002514">
        <property type="protein sequence ID" value="VDO37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H832"/>
    <dbReference type="STRING" id="387005.A0A183H832"/>
    <dbReference type="WBParaSite" id="OFLC_0000364301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000364301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000364301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="9">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000364301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16121" checksum="6F5F68282136E4A2" modified="2016-09-07" version="1">MHDEDCQLPSLDWLINSVKRKSSTLHIPDPSASNFLQHAKHSRIHNSQKSAPKDVDFSNEAIKPPYSYAQLITLAMRHHGQSKVLLSDIYDYVKKNFAWYRKTDITWQNSIRHNLSLNKQFIKLPRKKGEKGKGSYWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H853</accession>
    <name>A0A183H853_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Upstream stimulatory factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002533">
        <property type="protein sequence ID" value="VDO37352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H853"/>
    <dbReference type="WBParaSite" id="OFLC_0000366401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000366401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000366401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000366401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="14615" checksum="7618CA2AC8EB4BEB" modified="2016-09-07" version="1">LGKVGKVTNFRSAPALTGTAGPTSNDTVIVDTSSGTPTDIFGQSGTNISTSHHHHHHQSLGDEVTYVTNSNSLAVPATTTSTTTLKATTVTATTEVGFLTSEAEGTVETVVVRSNDINGSDESEQLSLMDAYPIGQITSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8G3</accession>
    <name>A0A183H8G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3776</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0389 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002633">
        <property type="protein sequence ID" value="VDO37714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8G3"/>
    <dbReference type="WBParaSite" id="OFLC_0000377401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000377401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000377401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009432">
        <property type="entry name" value="DUF1075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06388">
        <property type="entry name" value="DUF1075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO37714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000377401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20199" checksum="CBDC4831ACB0D259" modified="2016-09-07" version="1">MLPYIQFPKRLAPWPWYCGIRYGSSTTPAPGRIYSQRQLFEVKRAQLTGFEIETVMKLNLKHQLIISLLKANNPEKYALASDFLAHRADRPKSYKPEAPTGRTITPSPQEKRLLVLTGMYKRESDIPEFISEVRIAMMKERLNFMVSIFYVATFIIAFLTTIKAMYRTMTIAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9B2</accession>
    <name>A0A183H9B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4074</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002957">
        <property type="protein sequence ID" value="VDO38782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9B2"/>
    <dbReference type="STRING" id="387005.A0A183H9B2"/>
    <dbReference type="WBParaSite" id="OFLC_0000407301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000407301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000407301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000961">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO38782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000407301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10426" checksum="D5907BD221B857E8" modified="2016-09-07" version="1">MASVAHSSQAILTAVQPFYRPPNVEQHDTQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIRMLSSFRHDNVSIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9D2</accession>
    <name>A0A183H9D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4094</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002983">
        <property type="protein sequence ID" value="VDO38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9D2"/>
    <dbReference type="STRING" id="387005.A0A183H9D2"/>
    <dbReference type="WBParaSite" id="OFLC_0000409301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000409301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000409301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="71"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="263"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="370"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000409301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53160" checksum="D3CE94811351EEF0" modified="2016-09-07" version="1">MEETDFEEGLKLIRLVEVLSGRSLGRYNSSAIADRNLKLILGLVWTLILHYSISKQIWDDHAGDATKVEDVSPKTKLMTWLKGKLPAGLPFTNFTSDWNDGILLGALVDSCAPDLEVDWRNWLPSQALHSTRTAMHLAKAYLKISPLIAPEELISPAVDERSVMTYLSQFPGAKYTPRMARFRDIDVMPIVGVDSKFTLQMSNARTVPEINIRGPTESSISYTFCRISETIYDFIYQPKIAGEHQKLLQIVAIVRDEVSGNFAQLTSPIIIAVEGAHLLYDRNVQLGMPVEFTIENPGKDSIEVLVVAPYDEGFLVPVILDGNVYRGQFIPKQEGAYELNVFQKGKQIKRIAGSPFPLTVIAQVITDIHRKSVDRTQINIWGRGLEPNGIQSGEEVIVYADYSDSLLKSLHMRVHGPCVVIAGNEIPVSETVDGNLHLKIFKYRPREVGIHEVDVLFGENHIGKSPYKFSMDLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9I2</accession>
    <name>A0A183H9I2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4144</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003035">
        <property type="protein sequence ID" value="VDO39072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9I2"/>
    <dbReference type="WBParaSite" id="OFLC_0000414301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000414301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000414301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF15">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000414301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14348" checksum="9E0F55413B5D1C2A" modified="2016-09-07" version="1">MTTASIQKEEPALSVDPETAVFLPNGGKSEHMLVNISDKRIAVRCSDNSLFRVSPVYMFIEPGSCVNLVITRLPGPIKSDKLVFHYFACEPNDSEPKEVFKINSQKLPEMLKMPINIISADDVPKVKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9T6</accession>
    <name>A0A183H9T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4248</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003147">
        <property type="protein sequence ID" value="VDO39409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9T6"/>
    <dbReference type="WBParaSite" id="OFLC_0000424701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000424701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000424701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054291">
        <property type="entry name" value="DUF7027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22954">
        <property type="entry name" value="DUF7027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7027" evidence="2">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000424701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30628" checksum="7B416D87FDC2E79A" modified="2016-09-07" version="1">MDFDPDHPRWHFCCCHLRHALMILAGSETVVSLVVLLLSIIYVAVSNVKEVYNNIPWFVAILILFSIAYGQSSACLFFGVYKYKEYLMYPALTVRAVVFIFSYAIAFSILFQSSRVMDEVNWDNSEELNFQAGTNFIKLLLLIIFILFPISLFIFYTTNLIALCIHYVKTYEELRRMHSMNIPLQIDIAIHQLRTAVFNANIRKPKSEKPDRYNMSIFLSDKTYNCHTVNELNRAVNCISLSSITNRADQGSIDDCELHQKSTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAC5</accession>
    <name>A0A183HAC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS4437</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003373">
        <property type="protein sequence ID" value="VDO40006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAC5"/>
    <dbReference type="STRING" id="387005.A0A183HAC5"/>
    <dbReference type="WBParaSite" id="OFLC_0000443601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000443601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000443601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF6">
        <property type="entry name" value="PROTEIN PATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO40006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000443601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27773" checksum="BF5FB4B98CC10897" modified="2016-09-07" version="1">MGLDDAFDSRFQVLIQTSATKGSNALNKESLLKHVEIMQEIADFQVEMYGEKNFFNVLAMSFLTKFCDLRNWTLSDICFKPPAPQLALGPFAEVLIKLLNRLIPCIWITPIDCFWEGSKPLGPSPPLSLGPDVQAFINNLPKDGISWKNLDPTAVLKEVATLFDIGSLFNIFERTGIGSAYLDRWCIDPLDPECPLTSPNAFDHCGALKKFQTWNMAKPESEQIKLEAEEIRKPDDPTFQLLDNIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAY8</accession>
    <name>A0A183HAY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prefoldin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4650</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003638">
        <property type="protein sequence ID" value="VDO40626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAY8"/>
    <dbReference type="STRING" id="387005.A0A183HAY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000464901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000464901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000464901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO40626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000464901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16767" checksum="022AA3AA060B3801" modified="2016-09-07" version="1">MFFVRVALYIQLIQEGINKCKIFILIKKYRHELDLLEDDATVYKLIGPVLVKQNLIEAKQNVEKRIDYITTEMRKEKGLFCTFHMPCRKRLEELMADAATKQENQKQIVMRLQNAGRIMLRCNGYANLACPNRSGYSWADVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAZ7</accession>
    <name>A0A183HAZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein alan shepard</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4659</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003650">
        <property type="protein sequence ID" value="VDO40659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAZ7"/>
    <dbReference type="STRING" id="387005.A0A183HAZ7"/>
    <dbReference type="WBParaSite" id="OFLC_0000465801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000465801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000465801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000465801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15104" checksum="97E189A0608ADAF7" modified="2016-09-07" version="1">MRLVSSQPGTPQQLVIVHHQQQQQQQHPGNATIAPCSTTRGAETAVISTTQGSIPVANPGSLSGASTIHVAPQSRHVPHPAPQYVQQIQAQHASHPYLIVGAGPGISYLPSYVEERATPQSDPFTPPSYAPEMKNVVVLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB81</accession>
    <name>A0A183HB81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4743</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003756">
        <property type="protein sequence ID" value="VDO40920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB81"/>
    <dbReference type="STRING" id="387005.A0A183HB81"/>
    <dbReference type="WBParaSite" id="OFLC_0000474201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000474201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000474201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000474201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40116" checksum="217BBE83C7D2C593" modified="2016-09-07" version="1">MGIVGGEKVITDSGNSLFPGTLINSGTDESRSGSSSSSSLNNLTVGKASAQALALTKKRLELNDSEDDLNDESVNLVALDEVASGQYSELYVALNGEIHFYLLTLVKLIVDYTGATDELARHSPGSLHHGRRRVATNSETGTDSRSFAGSCSSISDLDMEASAHGTTATESHLIGLMKSMSDISCKKPVMEINWDPDDPAFVTTEVSVDSRNGRNSPGSASRRSRFPYCFKHHTVSFLTELDNRLISTDVLFGKSNDSARRRLSNTGPAVLSTAVIARSSSAPRLQTYKAEDEISVGEIRRFWPPLRSLETLHDNIRFSQLDRFLERLMKIRTPIPSPPKTPISTNRMTSVVAAELSDTAKKLERIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBA1</accession>
    <name>A0A183HBA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003786">
        <property type="protein sequence ID" value="VDO40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBA1"/>
    <dbReference type="STRING" id="387005.A0A183HBA1"/>
    <dbReference type="WBParaSite" id="OFLC_0000476201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000476201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000476201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000476201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35087" checksum="893E9AAB37EC4AAA" modified="2016-09-07" version="1">EEDCGWALKTRRHQGTYHRLNAEYNTRHEQWCKKPLMLLLLLLRCQYVPGEKNHRIRFHQQAARDSGQTEQNHKYHRGKSAHMSVDYSAHDFHESRAAIDAASRDNVHVQRHGDTTVVTEYRDPYSFYWQLDKARPREEETPKPLPQTDYVIDEEIINDAVLSPDSHDSGINVEVQYSRPMRVDDAPPAKPLPFGWERHEGMCEYPSGFSYYWHVDSGTIQREPPQTELPIVPMSIQPEFRDQETQADAFPTSPPVQQIVQLPAQQPIIEEHAFKQTTTKRSVNNDFSDNDDDITSKVGFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBL7</accession>
    <name>A0A183HBL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1794 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4879</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003927">
        <property type="protein sequence ID" value="VDO41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBL7"/>
    <dbReference type="WBParaSite" id="OFLC_0000487801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000487801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000487801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000487801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18316" checksum="340197A1A6F040CE" modified="2016-09-07" version="1">MLVKDGWREEKKQEKYLKSSPEAKDCVNSRHLAISRIQKVEDTRVNYLRNKQQKPVEKRGMDNDGAVMMSSFSLLIINIILLIKFIHAELTLNNQKLEWIIGSWRSEFSGKVFWPTVPTMTFGEELIIAEAPVAKSVNVQFLNFRSNLPLKETNVSIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCE9</accession>
    <name>A0A183HCE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004292">
        <property type="protein sequence ID" value="VDO42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCE9"/>
    <dbReference type="STRING" id="387005.A0A183HCE9"/>
    <dbReference type="WBParaSite" id="OFLC_0000516001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000516001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000516001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000516001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41031" checksum="82C778AA75E36C95" modified="2016-09-07" version="1">MLHISNEKKKTSLRMKYFLAAFCTYSLFFVDHVSAECREQVEVLPRNSRDPKIFQNLYIFENDTQKCNEAETLLISSRPPFCDSHDLNVTFSSIAVLPSGINMLPYILLNVSIWINNPSSSVFLRLECLEAPNLEDDYCHDHEEQYRRWGRMIWPCRSLTLSEPDLVNYPFFFGYHCFRLSSYSHYRLNVSCAPNLCRKSFIVTIPEETQVHLSINRFYNKDATNGENYWSPLVSVDLTLLDRVVIRYDRQPSFKSARISVAVFETIASSSVHLFTDTLDADAVEYEWKNVPAGNFTAYLYVSRIDCNLMCSNGISNECILCPNTRIHFTVEEDKIWFSVSVKSLLYYGIFIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDE2</accession>
    <name>A0A183HDE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004765">
        <property type="protein sequence ID" value="VDO43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDE2"/>
    <dbReference type="WBParaSite" id="OFLC_0000550301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000550301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000550301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000550301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12203" checksum="EBA65E242F0D64F0" modified="2016-09-07" version="1">MDSGLHTYNCHVAAFIHVFTNVFDRFNGATVLHVYVRFVIFDSKGEYGTTHRLSTSMSPFQICIVANLPPSSADLLLYKGYPPFPVTMLDTNARGYCLDHFFVYRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDX6</accession>
    <name>A0A183HDX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005020">
        <property type="protein sequence ID" value="VDO43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDX6"/>
    <dbReference type="STRING" id="387005.A0A183HDX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000568701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000568701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000568701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000568701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16122" checksum="B8F56DBAE4FA166F" modified="2016-09-07" version="1">METDRENCLCFRKYLLNSYEKAVRNYDEKLKQLHDIFMEPLQMIARDMFDLSHKLSKTKKQLEETLQLITITEQTNECRLEIAQIANGNSNSSISKSMKRNELSSLLKEFELHARQQKINAANSLALTQEWLHDMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE39</accession>
    <name>A0A183HE39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5750</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005111">
        <property type="protein sequence ID" value="VDO44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE39"/>
    <dbReference type="STRING" id="387005.A0A183HE39"/>
    <dbReference type="WBParaSite" id="OFLC_0000575001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000575001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000575001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000575001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21414" checksum="8F87E2F89D714CE3" modified="2016-09-07" version="1">MAADKMGNTVLMYAAMYSQSSLLNFLIEELSRQWCIEAFRTKNLMGYTAESLARKNERYMMLKKGRLRLLKRLRDQVTSNLMFAPPFHKWNVYSSIYKAKQKFLLCAQRYVQTLQDSTSSPARNSKSSLPEIQNHFHSGVSNGNPLKKYQSKTNSTANSVVVMNINLPPLSQSIVNVSTTFSDKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEF6</accession>
    <name>A0A183HEF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bromodomain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS5868</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005282">
        <property type="protein sequence ID" value="VDO44616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEF6"/>
    <dbReference type="STRING" id="387005.A0A183HEF6"/>
    <dbReference type="WBParaSite" id="OFLC_0000586701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000586701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000586701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF2">
        <property type="entry name" value="TOUTATIS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="185"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO44616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000586701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35452" checksum="8EDECBC0F7D6BD65" modified="2016-09-07" version="1">MKASCQICRTSENESQLLLCDACDMGYHMYCFRPRIAAIPDGEWYCPLCVQRACRKVLCLLCAKWNRPNSQPLEPIIMCSKCYNGYHASCFDRSPTLNDPKQWTCPGCLNADGFSTELANSLLNGDVEIALAQQEGQEKQTTCVQEDASGRQEAPRHRRRMTPADYDFPLDMMKNLFNTMLDELWVRPESGPFQYPVDTKEVPFYKKVIKKPMDLNQMRMNVESNKYLTQESFIEDLEQIFENCRTFNEDESPIGQSGVALHKFYLKRWKQLRYNYSKRLKRLKNPRLVHSVTVTSSSSLATNQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEZ1</accession>
    <name>A0A183HEZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6053</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005539">
        <property type="protein sequence ID" value="VDO45237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEZ1"/>
    <dbReference type="STRING" id="387005.A0A183HEZ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000605201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000605201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000605201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000605201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25106" checksum="A474B0C29F0070F8" modified="2016-09-07" version="1">MRPVIFTASALSAFVLFVCLSAMVYIKRDVQDAYRSLDVEMYNFKVITDDLWNELIILGRNPPKLRRRRQNGKASDSIHQNGEGISQSKTSPTVDNRDSRHDSHASPPSISPVQGTENDVSLDSNKFKLNDDRNKGLDQFFKPSGSNMDGKQRAKAFLPSGPQLAGVCIAFKIFVNQLGVMKVSESKRLDFFFIYGEKSLLHFILALSFFKVIVFYQFTTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF58</accession>
    <name>A0A183HF58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6120</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005642">
        <property type="protein sequence ID" value="VDO45490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF58"/>
    <dbReference type="STRING" id="387005.A0A183HF58"/>
    <dbReference type="WBParaSite" id="OFLC_0000611901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000611901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000611901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO45490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000611901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22763" checksum="CADA3C757084F9DA" modified="2016-09-07" version="1">MIHNPSTSAMGNAHDDDCDSLKSCASTSCSPVSTKRRKVSACSNSRPTTSSADCNDYLCEWNGCGKHFSSASSVLYHCTKEHVGDVHNIQCHWPRCDSTVRAKWSMVTHLQDHHCNEVALKAAAKRRKEGHGLPLGPVNPERPRDNVQHPGYSKNAAVEAIRRHAFNYLPRDITDDPEGPVTKSIRLTSCLILRNLARYSNDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFW1</accession>
    <name>A0A183HFW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing factor 3B subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6374</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006018">
        <property type="protein sequence ID" value="VDO46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFW1"/>
    <dbReference type="STRING" id="387005.A0A183HFW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000637201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000637201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000637201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000115">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000637201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26459" checksum="7E361B2480E85CCC" modified="2016-09-07" version="1">MISTMRPDIDNVDEYVRNTTARAFAVVASALGIPALLPFLKAVCKSKKSWQARHTGIKIVQQMAILMGCAVLPHLRSLVEIVETGLVDDQQKVRTITALCLAALAEAATPYGIEAFDSVLKPLWKGIRSHRGKGLAAFLKAIGFLIPLMDAEYASYYTREVMLILIREFASPDEEMKKIVLKVVKQCCATDGVEAAYIRDEILAHFFKAFWNHRMALDRRNYRQLVDTTVEMAQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGM2</accession>
    <name>A0A183HGM2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED15</name>
        <name evidence="12" type="ORF">OFLC_LOCUS6634</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006424">
        <property type="protein sequence ID" value="VDO47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGM2"/>
    <dbReference type="STRING" id="387005.A0A183HGM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000663301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000663301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000663301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000006">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019087">
        <property type="entry name" value="Med15_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09606">
        <property type="entry name" value="Med15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 15 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000663301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26097" checksum="717D302C59E2F4D5" modified="2016-09-07" version="1">MGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCVSKDEYMRTIAKVINAINCNSKSTTVPPLFQPSRIQSASQNYRAAGLGVPPDPQPTQQQQQKVMERYHTPLLGQPPPIIQSQQSSSNALSRTSMQSSQSNIQQHSPVTHPVVPQQTPYNMLSPIPSVPGSHSTSPNHQMYSRVKTEPKSGGNDGTNAAEVPISDSMSARVWKREDPSSGAYYPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGR1</accession>
    <name>A0A183HGR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6671</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006481">
        <property type="protein sequence ID" value="VDO47417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGR1"/>
    <dbReference type="STRING" id="387005.A0A183HGR1"/>
    <dbReference type="WBParaSite" id="OFLC_0000667201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000667201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000667201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO47417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000667201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24381" checksum="129F024155CEB88F" modified="2016-09-07" version="1">MTPEQRRAYNQKRSRAKKERERVMRAASEDAMSSLSSSINGNESSVQVNSTNSGMEQKPVIDSVVSEEVLSTLERDVLKRTRQANMVLMRQKRLPPQEQFVIVSTNPDGTQTVIPATTTEDGKQIFHIPATATTTEDGKQVFHIPAITQQLINADPSTLTLVDDSSKLLGTVQQPLQIASVPQLLGLPQQQHSNSHDHGETSHQVREVFFILSSSNILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HH88</accession>
    <name>A0A183HH88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted RxLR effector peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006768">
        <property type="protein sequence ID" value="VDO48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HH88"/>
    <dbReference type="WBParaSite" id="OFLC_0000684901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000684901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000684901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552538" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000684901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10353" checksum="7C38433E5BAE9C05" modified="2016-09-07" version="1">MWLYSTTVLITFTYLASSGNLANAKKQLKQDVNHTSAANHRRRYHLSPDEKKEMQVPMKIPKLSRAQKIALIIESGQNPFEKKRKRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHC2</accession>
    <name>A0A183HHC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006831">
        <property type="protein sequence ID" value="VDO48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHC2"/>
    <dbReference type="STRING" id="387005.A0A183HHC2"/>
    <dbReference type="WBParaSite" id="OFLC_0000688301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000688301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000688301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000688301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18997" checksum="671CB004861BF8B6" modified="2016-09-07" version="1">MLSRQVQTWRSLCRFTGIISKNARSCTTNASGKAEKDAKKSFLRVFSKFDRLFSATIWKIDDMKREKLAKFGRYCAECLPKFVQRVQFAAGDELELLIHPSGVIPVIAFLKGNHAAQFTNIVFITGMDVPSRKFRFEVSFLLTHSFETISKYIRFLLDNLCLGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHM3</accession>
    <name>A0A183HHM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory factor X, 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6985</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006992">
        <property type="protein sequence ID" value="VDO48738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000698401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000698401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000698401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO48738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000698401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14398" checksum="2E33894D792BCADF" modified="2016-09-07" version="1">MSRFYDKLFVYADTLCFTFLSGYPPGVSHLQSQNNQHPSSSAVFPASASGAPVTPVSRGTMYPPSSLVASQQSSGSQSAQYPPQSCYQAKGQQQPKYPVQSSVYRQQQPQSVSVRTYLGNQPSSLSASPTYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIV2</accession>
    <name>A0A183HIV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007728">
        <property type="protein sequence ID" value="VDO50883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIV2"/>
    <dbReference type="STRING" id="387005.A0A183HIV2"/>
    <dbReference type="WBParaSite" id="OFLC_0000741301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000741301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000741301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000741301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12849" checksum="9A776F5E16D178D1" modified="2016-09-07" version="1">MLRNDNQPKLCSKKINKQCHKATILTGFFKGKDVLNRILMIPTDVPFQFKRFPIRLAFAFTINKAQGQSLELCGVDLETDYFSRGQLYVACSRVGKQTICMSIQTMEQQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJD4</accession>
    <name>A0A183HJD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS7595</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008037">
        <property type="protein sequence ID" value="VDO51771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OFLC_0000759501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000759501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000073">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
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    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
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    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO51771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000759501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22425" checksum="7F32377C16A054FA" modified="2016-09-07" version="1">MWEAFENPHTSTVALVFYYVTGFFIALSVLCNIIETVPCKYLVDDTTISCGELYERQFFVLDTACVIIFTVEYLLRLFAAPDRCKFLHSIMSMIDVVAIMPYYVGLGFTNKKDVSGAFVTLRVFGLRILGYTLKSCASELGFLVFSLAMAIIIFATIMYYAEKKVNDTRFTSIPAAFWYTIVTVSSRSLLFFFFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJK8</accession>
    <name>A0A183HJK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
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            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008163">
        <property type="protein sequence ID" value="VDO52114.1"/>
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    </dbReference>
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    <dbReference type="WBParaSite" id="OFLC_0000766901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000766901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000766901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000766901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7680" checksum="861AB60A285D3540" modified="2016-09-07" version="1">MESGNEQVEYAREFTKFRILNSIEKRGTKKLFSVLPGFTVMSECEGTSIRLVDYVVIIEFDETQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK69</accession>
    <name>A0A183HK69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7881</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008530">
        <property type="protein sequence ID" value="VDO52977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK69"/>
    <dbReference type="WBParaSite" id="OFLC_0000788001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000788001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000788001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO52977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000788001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11855" checksum="8A29A2AE84D4CC0A" modified="2016-09-07" version="1">MFLMFSLLAGVMVITYIFFTKTGRNYVKEVKFKNSSPSSWRSFMSMKKAGGTTKRSSSQTSSYPTIPVFQNVFEHPPRPGSNTASQSITPLPPEYMSTTRTFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLJ6</accession>
    <name>A0A183HLJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8358</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009379">
        <property type="protein sequence ID" value="VDO55268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000835701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000835701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000835701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000835701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12790" checksum="B01F4AD9D3CB04D6" modified="2016-09-07" version="1">MKNMKDVGVVEFTYKNAGSKCNDSRDVRRFCIEIANEVKIREYADSSAIRDVIVRSTPQDSGKLSTTIEYPSDISDFYGCNTPENLSNEYEYSGYDSDDQFVHGDGFPWELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLL5</accession>
    <name>A0A183HLL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2OG-FeII_Oxy_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8378</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009417">
        <property type="protein sequence ID" value="VDO55377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLL5"/>
    <dbReference type="STRING" id="387005.A0A183HLL5"/>
    <dbReference type="WBParaSite" id="OFLC_0000837601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000837601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000837601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000837601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18479" checksum="A229A053486C1FCE" modified="2016-09-07" version="1">MPSQSGRRKQDYGPRVNFKHKKVKMDRFSGMPTYIDVILNRMNSISSDLFGSYQPFELCNLEYNDDRWSTIEMHYDDTWIWGDRLISVNLLSKSVLTYANEEKRLIIYVPLPTRTMVCMSDEIRYSWRHGVFPEHIHGRRIALTMREPSAAFKVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLQ6</accession>
    <name>A0A183HLQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009504">
        <property type="protein sequence ID" value="VDO55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLQ6"/>
    <dbReference type="STRING" id="387005.A0A183HLQ6"/>
    <dbReference type="WBParaSite" id="OFLC_0000841701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000841701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000841701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000841701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25494" checksum="993011D0C2D9056D" modified="2016-09-07" version="1">MLCRADRFSIMSLASNVPISVQNFGSDVNSVSEVTSLPMDLNMEAIDRSIQAQVSLADHGLQIEQSALSGCGVQTDIAQFEVDEIMLRLYNLQSKNRPKLMDRSMETSLEEANVVIVQGENTDYENSAQFLTYSVSATIPACVDVSTETERLIPMMVEQSVATEEPNHVFHRSMETDAWMPQIQMPECSRAVQTLFDDDNNDEDSRAKRKKKKISSINAFLIENRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLR1</accession>
    <name>A0A183HLR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009519">
        <property type="protein sequence ID" value="VDO55595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLR1"/>
    <dbReference type="STRING" id="387005.A0A183HLR1"/>
    <dbReference type="WBParaSite" id="OFLC_0000842201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000842201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000842201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000842201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11189" checksum="591EFB86417A42AD" modified="2016-09-07" version="1">MTNDACFGWLSPRATERALIRCSNLMNIQLIDPIDKEGKHLFDPNSLKDLIESKESKTSKKTNGTLHCCSDQAVSFGGLNYRNHRILDFVTNRIKVFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM24</accession>
    <name>A0A183HM24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8537</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009738">
        <property type="protein sequence ID" value="VDO56155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM24"/>
    <dbReference type="STRING" id="387005.A0A183HM24"/>
    <dbReference type="WBParaSite" id="OFLC_0000853501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000853501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000853501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000853501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19684" checksum="6ACA9A9381D68866" modified="2016-09-07" version="1">MQSARYCIPVVLNFQYNFKITGLTGEKSVSEVSAVDEDGSCFISSVIKEPGAKSDVDNAQTLKRVALKLLYLIQEKMTIIGYEIENLFEMLNIHVPEEQVKDIVSLYRSLFKRSLSLNALAQHFFDEPIEEEETDPIDLARLSLRLHAKFNELKEADEADINITALTQSLEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM84</accession>
    <name>A0A183HM84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8591</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009847">
        <property type="protein sequence ID" value="VDO56401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM84"/>
    <dbReference type="STRING" id="387005.A0A183HM84"/>
    <dbReference type="WBParaSite" id="OFLC_0000859501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000859501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000859501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000859501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17986" checksum="532A30BAAEAED672" modified="2016-09-07" version="1">RRSGLIGTDGWVAPEALISDASITCAVDVFSLGCIYYYVLTNGSHPFGDALKRQANIMQGEYSLKLLSTAGNLMAVSLIETMLRRDPSLRPISATLAVHPFFWSKERQLRFFMDVSDRIEKLSEQSFLLYRIEENSRHAIGFNWRNAICPILAAGSFFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HML5</accession>
    <name>A0A183HML5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THADA armadillo repeat containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010094">
        <property type="protein sequence ID" value="VDO57079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HML5"/>
    <dbReference type="STRING" id="387005.A0A183HML5"/>
    <dbReference type="WBParaSite" id="OFLC_0000872601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000872601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000872601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000872601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38219" checksum="6B75E7F4C37EA6A4" modified="2016-09-07" version="1">MPSDSSSMLVKLLGEAISEADICKVEAICYLLERIADYMTENDAITISQILEHCASLLSWHLTDDIYGASQLGKSLMNLLYSLSHLICTGTEADKQETVCMELSLAFINITDSTEEALKNLEKYVESRTTHLDIMDRVIQKCYDYFNDDQKPRRLRICALRCLGLSLAVHESDYVLKSLDSILTPRLKILQMLAEGCLPTSSQSTKSLEEECIFELDVLSSLIGTQKIQANSSVSESQLKEKNLSKRAVHIVLWQSMPLLLNLLRNFSSSEILVEKICDVLRSGLVAVQDDAEALLDSYCIVLDFIMLKHPVAACKLAKSVVLIYSSNNLNDLVVKLAIQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMU2</accession>
    <name>A0A183HMU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8801</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010251">
        <property type="protein sequence ID" value="VDO57465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMU2"/>
    <dbReference type="WBParaSite" id="OFLC_0000880301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000880301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000880301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000880301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10159" checksum="AD6B27C1867484F4" modified="2016-09-07" version="1">MDQLVGSILSIDITESSSIRMNEQYLSRRRPSCHACYCNQHAVSRSENVNTNFCTTQQNFACLFTQIRRYIIQDEEAKGFKISKSQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNJ4</accession>
    <name>A0A183HNJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRELI/MSF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9056</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010738">
        <property type="protein sequence ID" value="VDO58535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNJ4"/>
    <dbReference type="STRING" id="387005.A0A183HNJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000905501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000905501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000905501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO58535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000905501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22450" checksum="569C30CAADEC2979" modified="2016-09-07" version="1">HRYPNTTAKHVISEDLIEVAVDGDQIKTKKLILKQTGTFLKAVPRWMSCLTNVRVVPTIEESIFDRSKRSLVTYTRNITMLSICKIHERCVYKPGFKNGMPETVVERAGFVSTSFGKLNAIIERVLMTNFKKSMRKTVVAYMEKLTKRLLFIMFFLCYAWIIMSNTRALKFGEPALANHRTNEPHLLRQKIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNX8</accession>
    <name>A0A183HNX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011021">
        <property type="protein sequence ID" value="VDO59123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNX8"/>
    <dbReference type="STRING" id="387005.A0A183HNX8"/>
    <dbReference type="WBParaSite" id="OFLC_0000918901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000918901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000918901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000918901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12668" checksum="2F91FA444F802BE7" modified="2016-09-07" version="1">MDVSDGIAEWRDIVSPLHSSMNRNNSKRKVPGSIAPKEAKILKKIGKESTSDVSDDIEIAQSSSVDLHFSPSQIAKIVQELRTKVQQKKKNLSKKFLGFNDFDDIEMPPGGTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP10</accession>
    <name>A0A183HP10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HHH_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011085">
        <property type="protein sequence ID" value="VDO59232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP10"/>
    <dbReference type="STRING" id="387005.A0A183HP10"/>
    <dbReference type="WBParaSite" id="OFLC_0000922101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000922101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000922101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000922101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6816" checksum="51CA2860DC8949D1" modified="2016-09-07" version="1">AIKFLSVIRSLTASDAQRLIVTFGNIQKIASADIDRLLLCPGLGPTKARNIHAFFRATFQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR23</accession>
    <name>A0A183HR23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9937</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012721">
        <property type="protein sequence ID" value="VDO64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR23"/>
    <dbReference type="STRING" id="387005.A0A183HR23"/>
    <dbReference type="WBParaSite" id="OFLC_0000993401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000993401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000993401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000993401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15440" checksum="A4101C9A8BFFE41F" modified="2016-09-07" version="1">EDLRAAFDKFGRILEVRIFKSQGYAFVRFDKKDSACNAICKMNGQELCGQNIKCSWGRTPEGHNQQATAYNQAQAYANYGGYGAYGYGNGASAAPGGSAAAQQQYWNYYQQYYSNPQLVQQQWQSYWQQQQPQGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR75</accession>
    <name>A0A183HR75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAT_RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9987</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012835">
        <property type="protein sequence ID" value="VDO64936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR75"/>
    <dbReference type="STRING" id="387005.A0A183HR75"/>
    <dbReference type="WBParaSite" id="OFLC_0000998601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000998601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000998601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13155">
        <property type="entry name" value="KOW_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000021">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041995">
        <property type="entry name" value="KOW_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25092">
        <property type="entry name" value="SH3_KIN17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kin17 KOW" evidence="2">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO64936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000998601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5973" checksum="1ABD6D8B231FA307" modified="2016-09-07" version="1">MMLIVNGAYRGTRAVLQEIKEEQFAVVLRLEESFAKGRILCLPYEDACKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRL8</accession>
    <name>A0A183HRL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II toxin-antitoxin system HicA family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013202">
        <property type="protein sequence ID" value="VDO66088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRL8"/>
    <dbReference type="WBParaSite" id="OFLC_0001012901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001012901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001012901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO66088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001012901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8351" checksum="A766896E1FD838FE" modified="2016-09-07" version="1">MHSLRNLAIRAGWVVETSNENEITFVNWNKEEERGKKSQEVHRSSMPNNATAHTGQKCQTSFVYRHDNCYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRR1</accession>
    <name>A0A183HRR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRP9-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10173</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013290">
        <property type="protein sequence ID" value="VDO66417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRR1"/>
    <dbReference type="STRING" id="387005.A0A183HRR1"/>
    <dbReference type="WBParaSite" id="OFLC_0001017201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001017201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001017201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO66417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001017201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4581" checksum="9F4B4EA475C9C5A6" modified="2016-09-07" version="1">MTLKMTDDVVCLQYDTDQIQDVKRLEKLTATLMRHIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSR9</accession>
    <name>A0A183HSR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transcription factor Y subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014136">
        <property type="protein sequence ID" value="VDO69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSR9"/>
    <dbReference type="WBParaSite" id="OFLC_0001053001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001053001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001053001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001053001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16812" checksum="80E4C3ADD88C84E2" modified="2016-09-07" version="1">MINDIIIWEFSPSETWDYDLSRVQHLPYRFAGFRNLRSPSPSIMYPYEFARYYQDRLPRRPICPPEHGRYYPVPLSPRYTINPIYYPPPNYIYVSPNKRLPQKRKIISKLARRRGVMIEPSTGQIQIVKRRTHADIKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUT8</accession>
    <name>A0A183HUT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11253</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016031">
        <property type="protein sequence ID" value="VDO75121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUT8"/>
    <dbReference type="STRING" id="387005.A0A183HUT8"/>
    <dbReference type="WBParaSite" id="OFLC_0001125001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001125001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001125001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO75121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001125001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8720" checksum="338B1D30DBB16F81" modified="2016-09-07" version="1">MYLHQYWRDERLSWSHHFHIDEMTLSGDFSQHIWVPDTFLANDKQSFLHDVTEKNKMIRIEHNGQITYGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVJ4</accession>
    <name>A0A183HVJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11501</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016663">
        <property type="protein sequence ID" value="VDO76911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001150601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001150601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001150601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO76911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001150601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3576" checksum="0067B27237F420BF" modified="2016-09-07" version="1">MINEIFENILHNVAVFLFPDYFAWLIIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVS4</accession>
    <name>A0A183HVS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11587</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01016907">
        <property type="protein sequence ID" value="VDO77588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVS4"/>
    <dbReference type="STRING" id="387005.A0A183HVS4"/>
    <dbReference type="WBParaSite" id="OFLC_0001158601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001158601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001158601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO77588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001158601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21272" checksum="3013397F2B64EDAB" modified="2016-09-07" version="1">MCENAGEETNSSANPKLSVYRDCFEKHFIADTESYFANEAAEFIVANSIIEYMKKVEIRLKEEKERCDLYLHESTQDLLAKTLEKVLITKQLDLFQNEFGNLLESNKDSDLERMYTLCDRVENGLDELRVALEKHIARQGEAALDKIADVAVNVSIKKYLEKLILHLISFEISYQKKDRIISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW29</accession>
    <name>A0A183HW29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11693</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017222">
        <property type="protein sequence ID" value="VDO78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW29"/>
    <dbReference type="STRING" id="387005.A0A183HW29"/>
    <dbReference type="WBParaSite" id="OFLC_0001169101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001169101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001169101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001169101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5177" checksum="08152A33BDCBDF3A" modified="2016-09-07" version="1">MSQYRRIIIDDSSSDDDTNDNSGEVLDENQRNNSEDDENSDINIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWQ5</accession>
    <name>A0A183HWQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017833">
        <property type="protein sequence ID" value="VDO80347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001191701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001191701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001191701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO80347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001191701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7614" checksum="381E39DACE6A90E7" modified="2016-09-07" version="1">MKKNTGTNDCSYIINACSHSDSAIICEAVSEHDECGKKLTRNDFLKAHKKKIPLKGYFLQCALRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXB2</accession>
    <name>A0A183HXB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12124</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018422">
        <property type="protein sequence ID" value="VDO82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXB2"/>
    <dbReference type="STRING" id="387005.A0A183HXB2"/>
    <dbReference type="WBParaSite" id="OFLC_0001212401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001212401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001212401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001212401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14569" checksum="D247A3630F227C4D" modified="2016-09-07" version="1">MAERVVQIEKLQRKRNVITDEVFREFCQRINIKDIRQYEQREMRFHEEMQDQLKKFDNELDRLRNELDYLKSEDKRCNFLCFTNVSGGAFMHLFKGFSKIILNEFVLTFMKILTFEVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXE2</accession>
    <name>A0A183HXE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12157</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018516">
        <property type="protein sequence ID" value="VDO82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXE2"/>
    <dbReference type="STRING" id="387005.A0A183HXE2"/>
    <dbReference type="WBParaSite" id="OFLC_0001215401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001215401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001215401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001215401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7880" checksum="1C9B8690858A2A05" modified="2016-09-07" version="1">MSSSQNTTVLAESSANNSYCILDGNDSQNTDMMDFDDSSGPADPRLEKQQPQLLHADFYNDFGDLFDNVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYU5</accession>
    <name>A0A183HYU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRICHOS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12657</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039896">
        <property type="protein sequence ID" value="VDP11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYU5"/>
    <dbReference type="WBParaSite" id="OFLC_0001265801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001265801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001265801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001265801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35822" checksum="3868892A7BEB57A3" modified="2016-09-07" version="1">MEQQDDSADVYAPRSDASLIAGFTRSPSQSSEEMLTPWEQMVQFMRKIISRARNTTWTPRLICLLLLFLLLVTLFFVLLGIIFRALFGSYSARTLSLYPPICEKCHNSVYNQFPSRLHILFYSSSQVHFELTGNLPLRSNSFSVIDFETGYVAVADHALIDASGRHIACFLIPLDRSAIPSISALHDALSSVSSEIHSEYGWQEYWQYHAEAIDAKNAEHKFTNKIDQCRGAKWYLLKHTVYTRDSSCSNCYDFCLPNYAIQRLHKYEDDMSIGIRRLDCFRLYVPEWEKYQLIPDNQGGHWSYPVIPSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ00</accession>
    <name>A0A183HZ00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12712</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039911">
        <property type="protein sequence ID" value="VDP11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ00"/>
    <dbReference type="STRING" id="387005.A0A183HZ00"/>
    <dbReference type="WBParaSite" id="OFLC_0001271301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001271301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001271301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07204">
        <property type="entry name" value="Pat_PNPLA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001271301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58602" checksum="ACF62AA3A5E3A8F3" modified="2016-09-07" version="1">MPASGVRIINADPGRIYKASLSLSGCGFLCIYHAGVCAAIKKYAPQLLQNRISGASAGSIIAAAIACNVCISQATSLFLSVVSEARSYTFGALNRDFDLLKLVRTKLNDLLPSNAHEICSNRLRISVTRFHDMENVILDEFHTKDELLDAICCSCFIPVYGGFVYPTFRGEIYIDGGASDNQPVIDTNTITVSPFSGESDICPTDEESASLFEWNFGGTSIRLTANNLYRAAVCLFPPSTEECAAMCRSGFNDAQKFLFNNGFISNAVCLSTDADLLTKLNYINKGVDAILTSDSAVYEESHKDEKIAGYIDAVLATDSTQLPHSVQSVFDKTTKRNWFLDYIYSFRVMQLAHYMTLPLAATYQWFKFCQCLSTWLTARIARRIVDDWQSMRVKHIIDFILYEIHLQGTKVSARFSQQLTITEVEFSGIDQRSFVQEQLNINLSSEAIKEREVLRSIDRLLSKKSVEVCGFFCVREQTISHNNWSKCVIKQYLYDQIFNIVIFFLDCSLQQRNMTFVKTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ11</accession>
    <name>A0A183HZ11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12723</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039914">
        <property type="protein sequence ID" value="VDP12005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ11"/>
    <dbReference type="STRING" id="387005.A0A183HZ11"/>
    <dbReference type="WBParaSite" id="OFLC_0001272401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001272401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001272401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP12005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001272401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41858" checksum="A9BD793B4997294E" modified="2016-09-07" version="1">MSFKIGARVETEKGRGVVEFYGETEFAEGTWVGVNLDEPNGKHDGTVKGMRYFECEPNHGIFLKANQVRLESRGKSGMRLPTSIRKDVRSKISPVTSPKMTPSSSTEKLKTMSGITGPSAKKQSKEDMRESTGRLGGQSLSQTTMEESFNASQKSQSHTDETPLKSSGIPKKSSIVSKLGSVLSATNAEGKAIAESLPLSVPLPPDMDERSELEWLRIQHKDLSEKLESLRIKRKEDHIKLVEFERNRIQLESLLQFRAKILEEQTSLQRKLQEKEKELRDVLDSKGNENDSLAEIEERLELITIEKEMAEEKVDILQAEVEAEKQRVQELEVELDLLRSEMEQAGDGSFQACLHQRLYCNQWSSEIEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ46</accession>
    <name>A0A183HZ46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12751</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039922">
        <property type="protein sequence ID" value="VDP12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ46"/>
    <dbReference type="WBParaSite" id="OFLC_0001275901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001275901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001275901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001275901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="3980" checksum="04788D6E96D77115" modified="2016-09-07" version="1">MLISYTTDSFPVEYVPTVLAFSLFINSFCFAHCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0N5</accession>
    <name>A0A183I0N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13297</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040131">
        <property type="protein sequence ID" value="VDP13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0N5"/>
    <dbReference type="STRING" id="387005.A0A183I0N5"/>
    <dbReference type="WBParaSite" id="OFLC_0001329801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001329801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001329801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001329801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12928" checksum="3DE639FC4CEE9B3A" modified="2016-09-07" version="1">MENKGKWSLFASATDMNPFNGTIHNNNFDGNQNYRNSLIVTSPQFHVSDNEFEQFDLDNKHTYKEVSYNFVYNIDIINTTCFHAIPVMKPLRTLQISAKNSENLKKESLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I129</accession>
    <name>A0A183I129_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13441</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040200">
        <property type="protein sequence ID" value="VDP13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I129"/>
    <dbReference type="STRING" id="387005.A0A183I129"/>
    <dbReference type="WBParaSite" id="OFLC_0001344201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001344201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001344201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22433">
        <property type="entry name" value="KH-I_HNRNPK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="43"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="310"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001344201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41808" checksum="04B71D1D2C9E2960" modified="2016-09-07" version="1">MHQIIMKRQRIEDPYGYSYGYGTGLTAGKRHRQDSYQKALAEGKYELRLLVTSRGAGAIIGKKGESVKNIQAECNATVSVPDSQTPERLTEYSIINVVCCMFNCLSCYVVIAKIFRCFNCSVVQLVATVQNVVKCVEMIIARIDEVHDNQDRDSELKVLVHQSHAGAVIGRGGSRIKELREENGVDLKVYSECCPQSTERIIQINGKPEKIVACLVTIITTLKEVAEFLPLLTLIANFKAFVKSQVEHVKIPIKGPSRPYESVFFDPMVANEYGGYAVDHGGRGMRAYGPRSRIPLPPYGPVPPAYDDGPLETAQVTVPNELGGTIIGRGGERIRRIRDESGAHIKIEEEDPNGERIITISGTPSQIEMAQFLLQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I219</accession>
    <name>A0A183I219_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS13781</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040391">
        <property type="protein sequence ID" value="VDP14639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I219"/>
    <dbReference type="STRING" id="387005.A0A183I219"/>
    <dbReference type="WBParaSite" id="OFLC_0001378201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001378201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001378201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF116">
        <property type="entry name" value="HYDROLASE PNKD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP14639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001378201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30218" checksum="16C546050D23948A" modified="2016-09-07" version="1">MKMKKDSLAFRFIYRIYNTNCFGAWYTKRQLNRARKKRPNGHSSVATFTYGDIIVRAIPQNRDNYSYVVICRSTNDCVVIDVGDAQPILQCLNDENKIPQAVLVTHKHWDHCYGNKELKKMYKKLNIYGGEIDRPAHVNIYVQNETLIQIGKLHFKALHVPGHTAGHMIYALQLNNELKCLFTGDFLFIAGIGKIFEGNTAQMISSLLMLSDFPPNTIIFPGHEYANLNLSFALSLEKDNEELKAVSKAVHEKRAAHSPIVSDAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2H1</accession>
    <name>A0A183I2H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13933</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040480">
        <property type="protein sequence ID" value="VDP15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2H1"/>
    <dbReference type="WBParaSite" id="OFLC_0001393401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001393401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001393401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001393401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9497" checksum="B89D8A1A438AD8BB" modified="2016-09-07" version="1">MDVTQTLNEEHNAVVEMIDKTAVPMGRYPNIYKSPQPMLRLLFMEIACQRVGIQVKYDVYLVNIECKCYVSPMTWKRKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2U7</accession>
    <name>A0A183I2U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14059</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040569">
        <property type="protein sequence ID" value="VDP15389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2U7"/>
    <dbReference type="STRING" id="387005.A0A183I2U7"/>
    <dbReference type="WBParaSite" id="OFLC_0001406701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001406701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001406701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="61"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP15389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001406701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23232" checksum="FCF2B9E612682A8B" modified="2016-09-07" version="1">MYISTATLSKGSANHWGLNKLIACFIILSVSKNIIDFEKHEENMMKQKSSEETERKLLKEPHSIVIHRGKVGQFVRSLEHDMRAIMEPFTASKLKVMKRNNLKDFIVNGAVLGVTHLLVLTRGENSITLRIIRSPQGPTLSFRIKEYTLARHIISASKRKMHFQRLFISAPLVVMSGFNSNCGRHVQLVQSIFQNMFPTVNVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3R8</accession>
    <name>A0A183I3R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ISP3_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040806">
        <property type="protein sequence ID" value="VDP16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3R8"/>
    <dbReference type="STRING" id="387005.A0A183I3R8"/>
    <dbReference type="WBParaSite" id="OFLC_0001438801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001438801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001438801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001438801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19523" checksum="64AF01548AEF1AD4" modified="2016-09-07" version="1">MDFASFAAAALRNSAVLPCESFDNYWITNAPVQFGLKGVKCTFRFETSFAEAEDEAGTLVNGENRHTVYILWVSSCEDPSLLYSCRMDSTIDKVALRYGQRTPSILKNMIEGANMPSDDPRFTMINLIGEQEMGLFIRLCIVPGDGPSALRLALRTPSAAEWKNHLLWATFNQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4A5</accession>
    <name>A0A183I4A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IlvB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS14567</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040965">
        <property type="protein sequence ID" value="VDP17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4A5"/>
    <dbReference type="STRING" id="387005.A0A183I4A5"/>
    <dbReference type="WBParaSite" id="OFLC_0001457501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001457501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001457501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF166">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="60"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="281"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP17661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001457501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="59853" checksum="1A0BF1D7C1BBFD4E" modified="2016-09-07" version="1">MLLLLEILIILVVIVIWLFKFTGIDSIETLHQILVDFYFSDRSHWILDLFQVDENSDHYGGELVAAVLKAHNVNEIFTLCGGHISPILVAAENIGIRVYDTRHEVNAVFAADAVARLRQSIGVAVVTAGPGLTNTITAMKNAQMAETAVVVIAGSAPALLKNRGSLQDIDQLSLMRPLCKYVARVTRIKDIVTILKKAIHFAQSGTPGPVFVEIPIDVLYSYKTVFKELNLIKVKNFKQKIINAYILLHIFRQFSGGWRIGQNVLPIPPKITFPKNKDVMKLMHLLTKSKKPVLVIGSQTVLPPISVHELKDAVKAIDIPTYLVGMSRGLLGQQSRIHMRHNRKDALKEADLIILAGQVCDFRLSYGLNLSSRANIVSINRDRAQMLKNEGTFWRVNLMIQADVATTLVNLAHCLKSSDHEYRSSVQEWMLYLTRKENEKNAENMKKMSEALIGNGINPLHVLSLINKVLPEDAILIADGGDFIANAAYTVHPRGPLQWLDPGVFGTLGVGAGFALGAKAVRYAMLHKNLTTFVLKKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4D7</accession>
    <name>A0A183I4D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040987">
        <property type="protein sequence ID" value="VDP17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4D7"/>
    <dbReference type="WBParaSite" id="OFLC_0001460701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001460701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001460701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001460701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6885" checksum="AFD319094A69EADC" modified="2016-09-07" version="1">MGSKLELTDRNDSSKSKWSVIRFGEEPRHHSMLRSFRDEQYYTAKADRQRVSVDQKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4D8</accession>
    <name>A0A183I4D8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS14600</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="UZAJ01040988">
        <property type="protein sequence ID" value="VDP17797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4D8"/>
    <dbReference type="STRING" id="387005.A0A183I4D8"/>
    <dbReference type="WBParaSite" id="OFLC_0001460801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001460801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001460801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="217"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP17797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001460801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="603" mass="69125" checksum="FB9E0DC9AC5315AE" modified="2016-09-07" version="1">MFPSNVPQDGMTRSWCIISNSDIQILDLKKDSSKKSRTQQRKELEEQHWYHGLLSREDIEKLLVKNGDFLVRVTDIQGVHQIVLSIHIGERNIHLTIAVLVASFSYSEFIWKFPNIHKYSSCSTVIEANFSNSFKSFILSLIRIFHTRCRTSYSTEDGHFQFSALRRGKKFASIYDLVQYYKIHKIKVKDASGKDIRLGDGVPRPKWLVGYDAINYDKNAPPLGSGNFADVYLGTFVCNKDGNKQVIPVAIKIIKPEKDCGREAKQSMIREGKIMSFYNHENVVQFYGVACDRPPIAIVMEYCPGGSLENHLKKQKENIVIGERIEYCLEAALGMRYLHMQRCLHRDLAARNCLISMDGLIKISDFGLSKTNALDKDNFEMTDIPVRWMAPETLVKNPYFSKKSDVWSFGVLLYEVFNMGIKPWPNDENKKIATNIRHLRMPQMPVITPLPIKALVSTIWIKNADNRPSFKIICKKLYDMQKGDLKPPPIAECAVNRIPNVKRVEYTKIEHILDETEETVAEPVDGEGMTTEETIEGGKRVHRGPIKSFFVTPGPAHIVQFHFIEKCYIRCITLCIFTFFAMVGEINYSYHIVDSMINKCVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4S6</accession>
    <name>A0A183I4S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS14738</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041142">
        <property type="protein sequence ID" value="VDP18495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I4S6"/>
    <dbReference type="WBParaSite" id="OFLC_0001474901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001474901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001474901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552767" evidence="9">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="177"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP18495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001474901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50075" checksum="AC78EF484A1A4BED" modified="2016-09-07" version="1">MTSLLLALLLFGCGLSGSARNNKREIDAFQFTAPNYNVSLEENARGKDIYAIVNEPIRMGIPLPSDDAILKFRIVEGDRQYFKAEAKIVGDFAFLRIRYRNDGILNRELKERYEFLIKASCRRKDATNLETTVVVNLFVTDQNDAGPIFEKEEYRVEIKQNVCXXXXDQNDAGPIFEKEEYRVEIKQNISPFTTILQVQASDADIALNSQIYYSLVEWSFDFMIDPISGAIRNLRPLESGTYELTLLAEDRASRLFRKRAHIDNENNLFSHNKAKAIITVESVEKSERKLRIEVKPISASLWNVTQIVAIARIEGMTTEAIARLEIIDEEHAGAFVLKKDSGSNNVWLVETIAGIWPHADWFIQLKATVVDDFVEDLMGNISIELIGKRLIQFEDLSTLQISVNESVPIGYVVAQLKARVVNGFDGDDEQIRFDINIILII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4Y9</accession>
    <name>A0A183I4Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14801</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041220">
        <property type="protein sequence ID" value="VDP18876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4Y9"/>
    <dbReference type="STRING" id="387005.A0A183I4Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0001481201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001481201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001481201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001481201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13626" checksum="F8EB9CDA886084C6" modified="2016-09-07" version="1">MEGVKRLIGHVCTDNDFVRSFWIKNPESSTYYGDVPDEPKNWTSLFGSTSVSIRIMLVLVIGDFHIPHRNHNIPAKFRKLLVPNKMQHVLCTGNLCTRETFDYLRSLASDVHVVCFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I521</accession>
    <name>A0A183I521_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14833</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041260">
        <property type="protein sequence ID" value="VDP19090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I521"/>
    <dbReference type="STRING" id="387005.A0A183I521"/>
    <dbReference type="WBParaSite" id="OFLC_0001484401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001484401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001484401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10454">
        <property type="entry name" value="GIY-YIG_COG3680_Meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEM" evidence="2">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP19090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001484401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44687" checksum="55BCC13845ECD06B" modified="2016-09-07" version="1">IQQSFLHALNGLFSCARKKTSKTSLRQNRPHSWSPSYDGTGNFLSEEERRLRWAFRKNQPDFPSSETRRKKQFFSPVAPEDNTRGKNDSFCSRNSSNATYILSQEMESLKLGLTSLQGKDGEIKESPAEISSIKIPQKILAVVRQLSDERLKQELSKRGECIGPLLESTRPAYELKLARLIANLPSNVPKLKYSWALERWMAGHSFAEGSKLDQILINNFAELSDEQWRGGNRPTSFCYILIDPSFISVPSNTCTMQQFVDSIFYIGKGKRSRPFQHLVDAVRAKDFGNNVLSKSKKLQRIVDLWNAGHGVVSLHVFQNTIPTEAFTREAAMIDAIGLRNLTNVRRGDYYGLAKNWTTKEKTIYGSYLLFNALSIFHVEGCREIYENDIQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I646</accession>
    <name>A0A183I646_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15208</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041764">
        <property type="protein sequence ID" value="VDP20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I646"/>
    <dbReference type="STRING" id="387005.A0A183I646"/>
    <dbReference type="WBParaSite" id="OFLC_0001521901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001521901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001521901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001521901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8370" checksum="863F07D57D1B0E87" modified="2016-09-07" version="1">MDRFTGITSCADLVDPLRRSLIPSFLHSWPAFVGFPPPMLNASQGSVADVLLRPCWYFYCVSNAFFTVLLSTVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TSG4</accession>
    <name>A0A3P7TSG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS93</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000021">
        <property type="protein sequence ID" value="VDO24501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834526at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39385">
        <property type="entry name" value="PROTEIN CBG20422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39385:SF2">
        <property type="entry name" value="SLIT-LIKE 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="207" mass="24029" checksum="9AB0FB881A277902" modified="2026-01-28" version="1">MINFSLFATFYLSIISPAIYGYVFACLDGCQCDTDDEVIYCHNGHRTTLNLPDTRLRGFVVIGLTNNAIEKLPDEKSILEKYPDLKAIDVEGNEQFDCDSLKEYKTVKVYSDCEGSEPMITNGHRLPDINIGQPTDARIDILNNTWFQTCDFQCQVDKHYKILYNYLVKLWKMLKTKYDEIDKEKIVKDVQDFFVTIVKKIDELHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UEE1</accession>
    <name>A0A3P7UEE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001436">
        <property type="protein sequence ID" value="VDO33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="82" mass="9124" checksum="F9D648F4350CC419" modified="2026-01-28" version="1">MDALMSSDMKTTKDRRRKDGLPHSSGGRHKVLPINSYGFDEWFCVSASSIIKLFPNTTTTTDENASSQKVPELFGEEKEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UH14</accession>
    <name>A0A3P7UH14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001724">
        <property type="protein sequence ID" value="VDO34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="98" mass="10882" checksum="3C5193D2FD35BB2F" modified="2026-01-28" version="1">MRQVLNVTSGKASGGWEEEKGKMAKQDFHILSSPILLITPTLRANILVTLYYTVSWKGKLSLSLLASSSPKSLAVKDSSHYTTPTFIISTLFEIYSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UMU6</accession>
    <name>A0A3P7UMU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002273">
        <property type="protein sequence ID" value="VDO36431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7UMU6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="161" mass="18113" checksum="EF9763E5FFDAE77C" modified="2019-02-13" version="1">MFAKQTKFSVIFSWRRPLQPAPYPYSPVFDSYGYADTRRRKPPGKLPVMDVAVADVAPPPPLSSIPLSGILERRKEMDLQEHILRQQQVIDDLAKKLSTQNAAPDYTRHTEMNDPYAIMQAPSTSLLPTGSTTNKMPAWVTPSIYTQSQGGNSAETYEAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W3K1</accession>
    <name>A0A3P7W3K1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein heavy chain linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004126">
        <property type="protein sequence ID" value="VDO41834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7W3K1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="12">
        <location>
            <begin position="144"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO41834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="483" mass="56383" checksum="00D7700F706B4B55" modified="2019-02-13" version="1" fragment="single">MNLPIYFFSKVEQFRAAQRLLTQQRYQFPNSWLFSENVDGEWSALSDILERKDSAIQAQVANLQTKIKEEDEMVEKRTQDVLADWDKCKPVQGTQKPSEALVALATFEAKLNKVKEDRANMVKAKGALEMVEPVFTANHAAKLDTAVEELSDLKGVWQSLIPMYDAVDELKEKTWLSVQPRKLRQSLDELLAQLKQLPAKYRSYDSYEYTKRILQNYSKMNMIVVELKSDALKERHWKQLMKELRVSWNLSELTLGQVWDADLLRYESAIRQVLLVAQGELALEEFLKQVREYWQSFEVDLVNYQNKTKLIRGWDDLFSKLKEHMNSLTAMKLSPYYKQFEEDALAWEEKLNKISALFDVWIDVQRRWVYLDGLFSVSADINTLLPVESSRFSSISTEFLALMKKVTSTSRILDIVNMQGAQRLLERLADMLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIMGNSKDITRVQKHLKKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WCK8</accession>
    <name>A0A3P7WCK8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003755">
        <property type="protein sequence ID" value="VDO40913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WCK8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000291">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF337">
        <property type="entry name" value="ARISTALESS RELATED HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO40913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="171" mass="20109" checksum="7B210C8B8DDDC44B" modified="2019-02-13" version="1">MFLIRIQFSCSVKILLFYNIKALGFDCVNARKIYEHNYRAYLAPYSAGAVNDRSKRKQRRNRTTFNQQQLSELEAAFRKSHYPDVFAREELAMKINLPEARVQVWFQNRRAKWRKTERDDQKLDHCNNQNETVVSNVQLSDLDLIPQLSPTSLSTALSQFCSIRTLTQPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AJM9</accession>
    <name>A0A3P8AJM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040330">
        <property type="protein sequence ID" value="VDP14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="170" mass="19169" checksum="61C1157694E84714" modified="2026-01-28" version="1">MAKLCPGEKAFCLTKALQGQCYGSNVKAETLKRTCSCACDAVHFDRIQTCCKMLGRQGMEFCLPLCRYNTTLDELNTGLGYKCVSQLTTWAYCAADVRDNEECCKQRGIAPECLVFCKGDVPTCDLQSLFTYQPCLRHIETITHCHMKNLSSVPRWDPEWTGYCDWDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AMQ0</accession>
    <name>A0A3P8AMQ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01012101">
        <property type="protein sequence ID" value="VDO62285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8AMQ0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO62285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="71" mass="7537" checksum="5825939356675234" modified="2019-02-13" version="1">MIPATIRSQNGIALALASFGIAATLLSGGRTAHFALKLPLSMQIIETPTCSISKTFGTRKVLQKKQTYCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ASZ4</accession>
    <name>A0A3P8ASZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040195">
        <property type="protein sequence ID" value="VDP13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="128" mass="13997" checksum="6D3143318177F6A8" modified="2026-01-28" version="1">MSLPDFNRIISIDESTNCMTLSDSFITQSQPSQLADHKLYSSLIGLVGLSAWLACFLHLAASLVLPVFLAAFRNIEGPVGVWPGLVFWLYSVHLHNRANTKFISKAVLGGKGGGSVEVVLFKRKRPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B2Q0</accession>
    <name>A0A3P8B2Q0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042006">
        <property type="protein sequence ID" value="VDP21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B2Q0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16619" checksum="77509459CF136FFE" modified="2019-02-13" version="1">MLNNFKSQYSNFNLIVQEKFRRKELPVDGVYLQLAEVIRKNGISVIVGETGSGKSTQIPQVIYDVKTCLGRNCICTELILIIIQICYNEGLIGSGLLAITQPRRVAAITLARRVALEMNANLGEVVKLFYTSNTYICRNTMNVIYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CA70</accession>
    <name>A0A3P8CA70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040511">
        <property type="protein sequence ID" value="VDP15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2L7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="90" mass="10009" checksum="5EA80876A9421670" modified="2026-01-28" version="1">MSAPPPYQSPSYQYPPQQNYGGPGYTYPPQPQQPYYPNQPQPNFGYGYPQQPQIIQTTGPPQSSRYDSSKCCLWALLACCCGCCLAECCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8FQ80</accession>
    <name>A0A3P8FQ80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041825">
        <property type="protein sequence ID" value="VDP20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="451" mass="50964" checksum="FB866D104BA0330C" modified="2019-02-13" version="1">MKYVFIAQRFSXXXXIPYEPTTGKASTPSRIPVPTSALVAISQYGTPSPLKYGTPSPLKRSALVDYELTPQSHIHDKKHTPQQECSRVKSEHRNTNLMNSVTQIPLSRFAFEHLKSGGTPRPTSSTEKKWKKIAGDNSVLSIPATPIAKIDISQMLVDNVMRSGPAYRRRPHPPKLLSPIGKLRFDNSSENSNLSSKNTSQTTKVPQNSPLTAQEEMNDTKLVVIDSFNSDTVERLAENTANLSIAEQQQSILSEEPKAIFDTTTSEYRKQQKIPIFDTGNYFGRRRILSMLNESNVSVNTPGKEEDLTVVEMNPSFSGDSRNPSDTSASPVHIIAAKDENKHAAVLCARKIVHCEEAGQGLRRSTRNRVAPIRRWLGEKPIYRRDQQGTYELVRVEEAIIKDPLFIKYNTIDMSEVLERQKREQKQHARARKLRDLDRARRGYTKKDRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYL3</accession>
    <name>A0A183GYL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS323</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000097">
        <property type="protein sequence ID" value="VDO25392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYL3"/>
    <dbReference type="STRING" id="387005.A0A183GYL3"/>
    <dbReference type="WBParaSite" id="OFLC_0000032201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000032201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000032201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="8">
        <location>
            <begin position="443"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="9">
        <location>
            <begin position="535"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO25392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000032201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1148" mass="133768" checksum="667059DE135B9E65" modified="2016-09-07" version="1">MQQQAVFLEGDNAGGGSNDGILLTLHRKESLEYNPVPHFYSVHVKILDELKQCVCSYYHWFVLLFLLSDGIRLSSPVLSVVLIMLAFINLWRGADLYLSHPAVFIRKWRLITVYLLAAISIRIAALFMRAENSLRLQLEVTRGVGGDVTQNVATIKSFPKFLRKYMMIADGLLGHFLIYDKTNSISYMSFHVMLSYFSNSSEDNTSISFLLLFVFSERRYETVNVVIVGTFNAASLIYELIEFNNSIFRGVVLQTQLIYKAMTYHQQQDRRRLAKIKRTIETMTKVNLPLGEWFIECEFYRNHFEQGKIAVQQQEGIILINDNCWMVSECRFIISCFQTPYITISALLSACALWLARKTLGYRYIRFVINEEKRLLLEKLPAELSLVSQDSLSKLEKCNLGNEICLVTSSRDIIKYMNEVHDRWLKLPLLWRLLNAIGTFWVCNTALLCYLIIIVAHGQAACLFTFPLTILVFFWGAISERKRRLLWTIAIFYVQRNGFWYASSRQLLQNEGNKKCCLWSVLLDILRLRQRSPSNYYSWMILSDLFALIILIVNFSNFDLARRSAFTLLESNSSLLPDSFIILDRIIYLKRAIRAKFVYLVVEVIVIHVYILIILFISPQTDENRRMTSGLFIWYVARGIHMLSSAFQVRDGYPKFIVGDTMMKSNPISWALYVGYFYTVPVFEIATILDWTFTSTTLTLLDFYILKTINYYLYFIKGMRKFEAFYPRKRAELTSVSAKMFVGIFLPVQMVFTLRIDKHPILYEYHLEDLPLISDREYNHLIKYFAFDMYAQNFIKSLGAETIVEATLPSRGMIHYVHPDWKAQLMQLVNETTDRLKLKSRIYLRRMRVQEQRDNLLKKTDTTPLETAREWEMEMERQEVQDLSDVLGSTNCSDVFEMDISEIVRPLITVPNGGLMYEYPIIGEEQFIDGFAYFNYTFKYMTKLVFCFALIAITKKRGTDFFDKSPMPEISIFQQAIFDRTNCQPRQSESKTYFANRLILKPDCTENQIPIEGVSIPHVVMFEQYGVGHDGSIIGVAGALRFLFFVYKVSSSYLRLLNISTPSLVMTFAMIYLLSFKLRDILMTKPFELTFRELGDPSRLIRLCSSISIARETKLYDLEHDLYGKLIYILRSSEALIRYTQYKMKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYY6</accession>
    <name>A0A183GYY6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="4">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS446</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01000147">
        <property type="protein sequence ID" value="VDO25831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYY6"/>
    <dbReference type="STRING" id="387005.A0A183GYY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000044501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000044501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000044501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019346">
        <property type="entry name" value="Ribosomal_mL42"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10210">
        <property type="entry name" value="MRP-S32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="126"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO25831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000044501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38109" checksum="1E6D57A495F54E08" modified="2016-09-07" version="1">MNLIEVFSEPHTVVCKSGVVACWHPERSFPYKHSKPIDLKKIKTEKQSSGALSKEIECIADLQSSLSRTGPRNYLLREIFYTGKHEWYTSAADAIWLGRITYADGLRKQCYYVNKLLASRKLVSDSMKKSYLLLLEHTPVYTVGIRHFKYNEDEENRLKKLGADFYRTKRGGLITFHGPGQLVVYPIVDLHLLHVKGPDQNSTLVGVRRYVYLVEEAIIKTVRSFGLLDADRSSNTGVWLANGMRKIAAIGINVRDGVVSHGLALNCNTDLNWFHQIVPCGLVGKEVTSLTQELGRNVSVNDVFPIFCENFAEVFHFDIRIRGPDKLYEKDHLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ11</accession>
    <name>A0A183GZ11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS471</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000155">
        <property type="protein sequence ID" value="VDO25914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ11"/>
    <dbReference type="STRING" id="387005.A0A183GZ11"/>
    <dbReference type="WBParaSite" id="OFLC_0000047001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000047001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000047001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="420"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO25914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000047001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1239" mass="140385" checksum="6CC9045544A1E619" modified="2016-09-07" version="1">MRSPIGLLPFQSPLDLITKVLFEEKEKFSLVSDVNFSLDSGNTMEKSRITENEADESDSLSDDSNYYKPLRRRSATVSPAAGTRFRHHSKSRRRSEMNLIAQKQTPSLRRTDGSHVSPRYEHKDSLRKTNSMPSFEEAQKAHVEAIRQLLDLFPISPCNQSSSAHEVWQSHRQNLVPKMVESESEDDIINTDIEELRDAAQSIQSLQRVLKVPPEPTNINVEMVDRRTNCSVEGDSSSESLRQSGIASRLGGHPRGVIQFLPSAKQTEFFPALDTYNTYNKNKKVDKKSLLRRKTSLPEIYDQVYNSSDIIRPKAVNNAYKSGRWSFRSEIPNLQYSSKNVELMEQKTAIDSITGVSRFSKLLKSLRSSRQNSPEPHSSNSWNPLIYTSTYSGSSNPLMQADLLLWNKRSRTSIRRHNDVRNMAIRELCDTEKTFVENLEYLTQKYMRPLRQPLECTLIDPILADKIFYKVPEILIHHQHFLAALCDRLDTFQADARIGDVLLSHFRKQSMVDTYIAFVDNFKFSKQSIKQARERPAFEKYYMRCRRDHRNKLDLDSLLISPIQRVPRYELIVKQIIKHTSVEHADYDSLLVAQKYIHELATKINRQKEESEEMEQRLREIEAIVDGLDDLVTTGRSFNRYDVVTVLGVNQNKQRCLFLMSDQIIVTNVRGKSSPSFHSPDFLDNNRFKLLFKISLDDVVIAKDTLSLLHAAEIELQNVQEDINIVNKMTDLSRLLKKPNIELTNMLDNLEIEMIRRKRVLQEQLTSDPLLTIVQLQVTTTNGVGVLVIQFPNADRRAIWEHALIKAKTALSANLSFIYFIIIIFQESRCSESFAENELQNEERLNHLKSFITHRTRPGLTFSAAAATLGKSTEGAPNVWVCTSDKFSGQVAVINVNDEPTIESTTSIGNAAIVAICSVPAPRKKRKLPKLVDSPSRDLPGLELDSTSSESGDSDLETVRRNIQSTVWIGNEDGEIFVFNFLDNVRLKACEMMARLSMSIDDIVYLEEKVFVSISSGSNIQLFHFERNKEGKWDLDNPKSVQIDFRRRVKPMVVAASRLCFASGNSIYLLNTSSLQIEKQAAVSSSAMETVACLAVLGSTVFVAMTKSSVVKVINAFTLDCQQEFSVSHVVNKALSNSEDIVRKHKMGCLRITSLLCCNNRLWIGTSAGIVINTLIPNNKTSNWTPSLNVCQAGHIGPCRFLTAVSATATSSFNSRRRRMSLSAPTLQQIEQVSSIAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ72</accession>
    <name>A0A183GZ72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS532</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000185">
        <property type="protein sequence ID" value="VDO26114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ72"/>
    <dbReference type="STRING" id="387005.A0A183GZ72"/>
    <dbReference type="WBParaSite" id="OFLC_0000053101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000053101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000053101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO26114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000053101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8886" checksum="420640447870E300" modified="2016-09-07" version="1">MGLCVSQFAPAGDRHVWTTDDLLPAFVYVTVRAQLQHLGAEIRLIEDFTPQLQGSGQTELMFTTLRASYFQICNDKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H080</accession>
    <name>A0A183H080_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000363">
        <property type="protein sequence ID" value="VDO27471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H080"/>
    <dbReference type="WBParaSite" id="OFLC_0000088901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000088901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000088901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000088901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9524" checksum="3889C5675BD8BE2C" modified="2016-09-07" version="1">MIRAKRECGWMMRNGCMVWYLRWRENREDDKEANTAVETDDLTREHQHTDRRYQYHYIPHHALIDPTDPSPFPTISHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0C5</accession>
    <name>A0A183H0C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Voltage-dependent T-type calcium channel subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS935</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000384">
        <property type="protein sequence ID" value="VDO27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H0C5"/>
    <dbReference type="WBParaSite" id="OFLC_0000093401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000093401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000093401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008332">
        <property type="term" value="F:low voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000119">
        <property type="entry name" value="Calcium channel, voltage-dependent, T type, alpha 1H subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000125">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000007">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000117">
        <property type="entry name" value="Voltage-gated Ca2+ channel, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF230">
        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1158"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1256"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="69"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="655"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="1119"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="471"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000093401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1355" mass="156539" checksum="A040D41EB80CDFA5" modified="2016-09-07" version="1">MEVSPLKPWRDSILEEDDYQKQTQVGWDSEEDIINDECDLPYPGFTESSLHCLRQTVPPRSWALRMVMNPWFDRITMLVILINCVTLGMYRPCEDNDNCTTYRCYVLSTIDHVIFAYFVLEMMIKIVALGFFGSSAYLSDTWNRLDFFIVCAGCAEYLLQEYLGNINLTAIRTVRVLRPLRAVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVISLPEMNDIIDISDMSLTRYYIPEDTSLEYICSQADSSGLHTCNNLPPYVYNGVKCNLTIREWANLKNDTTECINWNAYYNECKVMHRNPFQGSISFDNIGFAWIAIFLVISLEGWTDIMYYVQDAHSFWNWIYFVLLIIVGAFFMINLCLVVIATQFAETKRRETERMIEERKRLRSSGSLSSDPAHSSRDGEQGDSIYAAIIKSIRHYSRRLKRRFLKQWKIWEERFATRRKFFKGHSNNTHPKTANSEEMKVNDSEETKMRDSEEMKVKDSEETKTEDVPVVNATTDITDDKLLPLGSTHRERSKLYVSIKNRKWSGNFTSNSPESDVEIGSTNDNQSKPLKRSIQVGELSSGEESDIELSDQISGNELECVDVGGVGSNYGYDHNSRVKPEKPIKSNTTLFGRFREKLRAFVVCNHFKRGILFAILINTLSMGIEYHQQPELLTTVLEISNYFFTGLFALEMLLKIGAEGLFGYLSDGFNLFDGGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQLVVMLRTMDNVTVFFGLLVLFIFIFSILGMNLFGCKFCKNPVNALDQTKKCERKNFDSLLWALVTVFQILTQEDWNVVLFNGMARTTPWAALYFVALMTFGNYVLFNLLVAILVEGFQESKEEEKRQLKEEAMKKATVEEEERERELELFLAKASSSTYLNQRKTSSYYTYSRGPGNFQAFQDVYHKRYSVPTSPDEEEEDEPLGHQSFLNRRTSSLNRRRLSRNINPNLNFSLYRHTSLILPQMVPYFDPYSRREIRQRMNSWCGMQTRLKPLHSINGRQAIIEAYTRDKLIEANEELQLAIEEEERRKIERRNTKFMRLLRKTCFYKRADYSFYIFSSENRIRIKCLQLTQKKWFDYTILIFIGINCITLAMERPSIPPKSLERQFLTFTGYVFTVIFTIEMSMKVIANGCVLGKDAYFKDGWNILDGALVIISLINIIFELLVHIDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMFHCVGPNISNVTTKTDCLMDPRNRWVNHRYNFDNLGQALMSLFVLSSKDGWVAIMYQGIDATGVDLQVIDVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0J4</accession>
    <name>A0A183H0J4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000420">
        <property type="protein sequence ID" value="VDO27861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0J4"/>
    <dbReference type="STRING" id="387005.A0A183H0J4"/>
    <dbReference type="WBParaSite" id="OFLC_0000100301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000100301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000100301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO27861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000100301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35593" checksum="73AC7CF3FC197BF5" modified="2016-09-07" version="1">MADVKSGDLWDVGSERTEDSSMKTEFEKEDDSGTSVSSNEDFEIIGDQARISGHVANVLFCDLQQKRATESETLTCTSKTGRTEEENEIENKSGYSCFLWKMMFLITVGIITSLLQLRLKCPESADIAHYGTPIAIFKIQESTFKENEHHDETLKETIARQQQIIKKLNNQLKSCTPLDVYNLPVRVEEERATAFERKDGFNYFFVIVDWKKSNRGKAQQHLHLAFKQSNSSIYVYDHGPLSGKYFTVGDRIIDIDGITFIRAVDLRDRILWSHHNKDHFTSIIERPATKQAINTVLALLQPSLSSFSVVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0M6</accession>
    <name>A0A183H0M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YcaO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1036</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000441">
        <property type="protein sequence ID" value="VDO27985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0M6"/>
    <dbReference type="STRING" id="387005.A0A183H0M6"/>
    <dbReference type="WBParaSite" id="OFLC_0000103501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000103501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000103501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF5">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000103501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32180" checksum="AD941DE350803174" modified="2016-09-07" version="1">MLEDVLSHDNQYIECSQVRKSQKANFYTNQEFSANVQRSHSLTLFGITNAETIDLIFPNWFNQAFEGTENDAAYRPYDLNMPSTLLKRPIMHYQADSPITEHGKICAALIGRGILLTGYKPKIIFTSPEMRCIETARSIQRSLHINNCDLCVEPSLAEYTRFRDNAEKYWLTTEWLQQQGILSSDRTYEPLLKLEELSRNETPQEFVDRLQRFYEHIIMNFEDRTSHYFRCSIIVSNITGIFVLCDGTAAVPWHLQEAHNNMNNCHLCAIEVTPDGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1C9</accession>
    <name>A0A183H1C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1289</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000583">
        <property type="protein sequence ID" value="VDO28987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1C9"/>
    <dbReference type="WBParaSite" id="OFLC_0000128801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000128801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000128801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO28987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000128801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15993" checksum="E57105A55554A7F8" modified="2016-09-07" version="1">MAADVCAEQLPSTSYASTVAISSSSTTPIMQASQALVKAATSTTLHLGSCYISRSASSASVNYHQDDEEAEAAFAISSLPPEIHLHILKHLPRCDIDNCRLVCKRWKEMIDRNIHSLRKHLVQMLELREYKSRFILTLKYILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1F6</accession>
    <name>A0A183H1F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1316</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000597">
        <property type="protein sequence ID" value="VDO29090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1F6"/>
    <dbReference type="WBParaSite" id="OFLC_0000131501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000131501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000131501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552336" evidence="2">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000131501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15698" checksum="63DF26A6C7C43BE3" modified="2016-09-07" version="1">MQTGTWLAAIMTSLLVIIDNQYCVSYTTDSNTGTTVAINTNVLPVIINDEQKAGTSHDYNGLSAYNRLRHSERQRRRYKQMLQQKQKQQLQMHRSDSSSMDDKFFDNFRRPLNVNNNNNNNNGVIRNKLKAHHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H299</accession>
    <name>A0A183H299_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1609</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000793">
        <property type="protein sequence ID" value="VDO30150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H299"/>
    <dbReference type="STRING" id="387005.A0A183H299"/>
    <dbReference type="WBParaSite" id="OFLC_0000160801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000160801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000160801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000160801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="678" mass="76084" checksum="510D1DCFC5F0E25F" modified="2016-09-07" version="1">MFIYLGNTIGLVSSSIQYTRETMPGAQYYDGKKLNIPISKEAGIELFERWTHQAISSIMACIATQYLSKLNEYERNRLQKCSRAAEDIHQQARCLVRAIDAKPKQIKPTRISRIQKLQKLLDGKQKKTVSTQIQSESHHIDVKPSKEAKKVEFRTRRSVINRHNYKLHTEFENLTPFGILGKYLSKMTKIIKNKDLNSSWKKTMYDIENIKQREQKKIEIAEQMRKRFPLKQYFENMKPKLILNEKYLAKELNISDHLLQRFDKTNVNTLEIAQLLQRAIKLALVLSGVNGTELENKTLKFGSPRLLSLVPDNVKDQINILSPSLFSVHDKGESLETLTSIPKLMNVSGNRDYEEWLNFIIEVSGTTEAIQELKEKQELDWLPPAYKSMPRGIDGQPLYFTKKNVTEIDPELARKVELFENLSYSLTPKQIAEFNTTGFSMMTSKQLMMFYGPQSPLNDSKSLEFFLSLSEDDMHRFLLNDIRKLASKHSSLKLRQKRQNILHPTALTTSNLATSALQLSVLSPSILTLSLLSPSILGITLLSPSVLFASFLSPSALSPSILSPGAMGIILLSPSAFNPSILSPGALTPAILSPSAFSPRILSPSILSPALLSPSCLNPSAFSSSAHNIVVLSPSCMSPSYWSHSFHNSVILSPSFNSPSFNSSSEGNTVIFSPSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2K8</accession>
    <name>A0A183H2K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS1718</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000863">
        <property type="protein sequence ID" value="VDO30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2K8"/>
    <dbReference type="STRING" id="387005.A0A183H2K8"/>
    <dbReference type="WBParaSite" id="OFLC_0000171701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000171701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000171701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000171701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24369" checksum="92673C8BEE69D723" modified="2016-09-07" version="1">MTSGDAVTGDIVQCEDFDTSSGEPPRIDLERRAFNSGLQANRTLPSEKLLKKGSADVVKTDTTISKFNTTYSFPTFYESEELNNKIVEKMELGEIVQTHVTTPLVPTSIAITGSNLPIPVASELSNVSSTGSVSDREPEVPDKSNYTKIVKSLEQKPLRKRRRNDGYPPKNDRKITECFKVFFSLPSTFFPAVELISCRKHGSWFQPKASNKRISCKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3K7</accession>
    <name>A0A183H3K7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS2067</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001116">
        <property type="protein sequence ID" value="VDO31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3K7"/>
    <dbReference type="STRING" id="387005.A0A183H3K7"/>
    <dbReference type="WBParaSite" id="OFLC_0000206601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000206601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000206601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDO31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000206601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36650" checksum="83A8FD9270FA9902" modified="2016-09-07" version="1">MGLCKCAKKKVTSLFCFEHRVNVCEYCLVENHSKCVVQSYLSWLADSDYDTNCMLCSTPLESKKTVRLKCLHLFHWECLDAWACRLPRNTAPAGYKCQQCQEGIFPAPNQTSPTIERLRTILQQANWARAGLGLSLLPEFDNLPSAASFIPSMTAPSGNEKQSHMSGPDVLHEANLNAECIRSSTPATVIDVDDEYNRQEQQHQFTARKSMNLNENNYVSANPLLHSRDRDEDLPENKYKRRSASEWLNRWFRSRYGRHSVFDTRAQWKHGIFYIIICIIIMMTVFTVLSRLISNPSNDDPAFNPLANPDIRIAFPEHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3L5</accession>
    <name>A0A183H3L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001120">
        <property type="protein sequence ID" value="VDO31780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3L5"/>
    <dbReference type="STRING" id="387005.A0A183H3L5"/>
    <dbReference type="WBParaSite" id="OFLC_0000207401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000207401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000207401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000207401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14236" checksum="F3C336AD8A08B8BE" modified="2016-09-07" version="1">MPTFPTRYVPYSIVLLVPFEKDNKKVDCDKTPLKVRLYKFEICYALVTSLLSIVLTKTSINGILGRGGMHLFSLNQLQQFLEVSTEWISHDKRLLDLGAGDGQITAVMARLYKTVSVTEASKIGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5M6</accession>
    <name>A0A183H5M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2786</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001689">
        <property type="protein sequence ID" value="VDO34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5M6"/>
    <dbReference type="WBParaSite" id="OFLC_0000278501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000278501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000278501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000278501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9289" checksum="83CAD67576185BE6" modified="2016-09-07" version="1">MSLAQILIDDYSSDVLVAMQLNYFGTKIGRILIFCLYVKSVHKGFANVRKGQKIIIQLTVMNPNLRNWTDFNATLKSQPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5T5</accession>
    <name>A0A183H5T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2846</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001742">
        <property type="protein sequence ID" value="VDO34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5T5"/>
    <dbReference type="STRING" id="387005.A0A183H5T5"/>
    <dbReference type="WBParaSite" id="OFLC_0000284501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000284501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000284501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000284501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18648" checksum="9A2C5C7C360E0304" modified="2016-09-07" version="1">MDRCQMLWNKIDQLPLLSTVTLLRVGDRCIDRDHKSFAELYESVIKRNNKLHECLDKHHYQLDESADCSVMSTNRTQWHSTFMESDDLQNTKSFADCLTHVNAVQFKCAQLCKCCPHFDKCRDETFDAKAELQITSLTVQLITQNYDCLRHKLMKMVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H622</accession>
    <name>A0A183H622_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TFIIIC_sub6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2933</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001824">
        <property type="protein sequence ID" value="VDO34716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H622"/>
    <dbReference type="STRING" id="387005.A0A183H622"/>
    <dbReference type="WBParaSite" id="OFLC_0000293201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000293201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000293201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000293201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15964" checksum="BFC60E6948FC3DEF" modified="2016-09-07" version="1">MFISVDSHTDDINKQDSKTIEQNEEWESKTVILEIGGIMDVNAARQALNRGDSAIRRCNTENPILQISNSLFTTEWNSIIGTDMIFKLEEKQLRFVECSDVRLKAEKALIIDNDDNSMEIVILPSIFEKLDIDVDKWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H675</accession>
    <name>A0A183H675_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase D3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2986</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001867">
        <property type="protein sequence ID" value="VDO34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H675"/>
    <dbReference type="STRING" id="387005.A0A183H675"/>
    <dbReference type="WBParaSite" id="OFLC_0000298501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000298501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000298501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000298501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50389" checksum="64B97B8FC3BC651F" modified="2016-09-07" version="1">MEWHNFRFHFVESIPENMTYPEQSNFPSTTEIWKRLISSAEKSIDIASFYWSLLSENTGSYRGPSTQNGTDIYNALIGAAKKGIKLRIVQNAQTNNETRTLENEGLAEVRSLNFSNWFPSGVLHTKFWIVDAKHFYLGSANLDWRSLTQVLKLTVKELGVAVFSCECLAEDLMKVMNVYWRMGAPGKKLPSSWPNDLATAYNASNPMLAKLNGERNGVYISSAPPTFCPKGRVDDLSAILQVISTARDFIHISVMDYFPATLYLTNNRYWPVIDDALRKAAYNGIKVKLLISKWKTTRPTLFAFLKSLEVIASTLPCKRTYDTKKRKLVCIPDTVGSIEVRIFVVPTVGDQEKIPYARVNHAKYMVTDNSALIGTSNWSADYFTNTAGASIVIQQRNRTPNSKIVYNLNEKIFMRDWNSTYASPLSDFDDKGHRIRNDTVIFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H682</accession>
    <name>A0A183H682_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2992</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001872">
        <property type="protein sequence ID" value="VDO34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H682"/>
    <dbReference type="STRING" id="387005.A0A183H682"/>
    <dbReference type="WBParaSite" id="OFLC_0000299201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000299201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000299201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000299201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10734" checksum="28775B24B44A273A" modified="2016-09-07" version="1">MKRKNSLFLSSVSSFGDSEGVEIAMEMAPGEPLRLSPELITEHIIMSEYAMICRDPIDGLYTVPSARNKFGNSVYYFFLHMYDTSLSKFLHIFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H738</accession>
    <name>A0A183H738_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telomerase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002168">
        <property type="protein sequence ID" value="VDO36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H738"/>
    <dbReference type="STRING" id="387005.A0A183H738"/>
    <dbReference type="WBParaSite" id="OFLC_0000329901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000329901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000329901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000329901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="48043" checksum="29BABF34A657D567" modified="2016-09-07" version="1">MTEQKNSLIASRICFRSSSRSWLNHRQGRMVSYPLRHTHYAGSISLCNEMIGAENFNKLDHLQQLFLEEMCSRILRKLTALSIQYFLDHTVPRLNDSDVASLLRKSVTYVQYRAFMSAIFSYLLPHGLVGKCNMELAVGRISSTLFKLGFDESIRLNDLFSTPFKTSALKWLRHLSSYELCCIHRKFMLWLLEFSVHVTRQSRILCNTRKQNETVTFLPKRYMETHRKSQFPFKVKGVMKSTVGVRIRFLPKNSGTRSLIVPTRKSFLRQYSTIALKIASAVIDLICAKQRKYSKELPFTGAAVWNGISGFPKRFRRFIQMNGSARIYAVKTDVQECFNCINHNLLRTVLRKFILLTKHFRLNANVIGMSSLIFARQYGFRCRIDDHNCNLSELCVTGEMVMWFLETYVINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H797</accession>
    <name>A0A183H797_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002222">
        <property type="protein sequence ID" value="VDO36233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H797"/>
    <dbReference type="STRING" id="387005.A0A183H797"/>
    <dbReference type="WBParaSite" id="OFLC_0000335801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000335801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000335801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000335801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9698" checksum="0E504795C7FB0B56" modified="2016-09-07" version="1">MHSQYQLDRSDNIAEQFKDNMNRNIFEGTRLASLFGILDLIKKKDRNAKLEFRDLRDNWIKYDFEDLRRRSQQSVIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7I7</accession>
    <name>A0A183H7I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3449</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002301">
        <property type="protein sequence ID" value="VDO36529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7I7"/>
    <dbReference type="STRING" id="387005.A0A183H7I7"/>
    <dbReference type="WBParaSite" id="OFLC_0000344801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000344801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000344801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF50">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO36529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000344801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32153" checksum="D51DB09830711E8E" modified="2016-09-07" version="1">MCRKNLCSRYRNYRIAVFSSTIAWVLAFSAAIPLYLYSEVVELPTNSTGGYTRPVCIAKWPSLTSARWYITISSILIYVVPLALMTYFNYHVLMKLRKALRNNKRMRRTSQSRTPYHRVTRFVLCVVIFHVACWSPFWLFNLLSSVFQFRIHTRFNRLIVNIIHLFPYINCALNPLLYAANAADFRRAFRSLFFGSFNRRIPLSSAKHQVPRTIAIDRIDPYMVTLPFLHLTIRKRRLIWCNERNRGIIARSLTKPLNREEIVVEHVELNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H829</accession>
    <name>A0A183H829_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual specificity protein phosphatase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS3641</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002510">
        <property type="protein sequence ID" value="VDO37272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H829"/>
    <dbReference type="STRING" id="387005.A0A183H829"/>
    <dbReference type="WBParaSite" id="OFLC_0000364001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000364001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000364001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF9">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO37272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000364001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25334" checksum="1BC83B6A45C9C103" modified="2016-09-07" version="1">MVMVETKECHTVASTSFLINPTPEYGQITELVPRLFICDASSLTWDNMNKYKISLIINATTEVPSIRSLGSIPRIKLWLDDTPSTDIYQYFDLISDQIEMTIAAGSNVLVHCVAGISRSATICLAFLTKFRCKSLRQAYLLMAQKRSLVRPNVGFWRQLITYEKEIKNCMASVKLVRSRENPENVLPDVYLSKSADSRGGWRSTKDKLKFLPMLETVPEGTEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8C6</accession>
    <name>A0A183H8C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002605">
        <property type="protein sequence ID" value="VDO37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8C6"/>
    <dbReference type="WBParaSite" id="OFLC_0000373701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000373701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000373701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000373701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11916" checksum="1267FEB3BE48737D" modified="2016-09-07" version="1">MDLILCNTQTASFPAITHLWRAPQPYIPYYFTSSPPQYSPFSPHLPYFSNPTTTRQQRKYQNKKAQKSSKTHFWCGGIAQLLWTIALIIVLGLLAMLILALFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8I3</accession>
    <name>A0A183H8I3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3792</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002654">
        <property type="protein sequence ID" value="VDO37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8I3"/>
    <dbReference type="WBParaSite" id="OFLC_0000379401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000379401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000379401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000379401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9879" checksum="5171CE92DC3BF090" modified="2016-09-07" version="1">MIIAPGWKWYTISACICAKLNEQFPLQFVHFCCSSASYRLHWETYLCTSSPPGPAPSPFGLAYLTLSDHSFLHPSSSSPPLSIEFSLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8S4</accession>
    <name>A0A183H8S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DCB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3886</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002756">
        <property type="protein sequence ID" value="VDO38106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8S4"/>
    <dbReference type="STRING" id="387005.A0A183H8S4"/>
    <dbReference type="WBParaSite" id="OFLC_0000388501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000388501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000388501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000388501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24217" checksum="429C3179E8D58788" modified="2016-09-07" version="1">MTSGPHFSPTGRPISRQNTERERVKNVLQESFRRALRVKSCADLCDITRCLKQLYIDALNVPGGIERYLAALRFALELTCEKSNEKEGRINCLKMSAHVALALSQEGLHEPLQLLVDFCVDMNDLCVTVTRSYVCALAGLLLNLNKLISNRLREQNPQKTNCSPLSKELRTSLFAILSKRLLDVVSLFTGFSRIVKYLYVENHLAMLFRYTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAC9</accession>
    <name>A0A183HAC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003377">
        <property type="protein sequence ID" value="VDO40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000444001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000444001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000444001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000444001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18798" checksum="311F426F1E457618" modified="2016-09-07" version="1">MLTVFYMLLLAIADLIVYTAMTSSSSFTYVSAINAVILLAILLALYGIWKELSLCMLPLIVIQVLLGAMMILTLIFSNFIEFHCFLIEICPGGRFLILTMGSAIFCVLHCYCVIIIWLCWKFFRYLEKKTKLERTWHIETIDDDIDEKILIHNMSFNANFTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAT1</accession>
    <name>A0A183HAT1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphotransferase</fullName>
            <ecNumber evidence="14">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS4593</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11028"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="14"/>
    <dbReference type="EMBL" id="UZAJ01003557">
        <property type="protein sequence ID" value="VDO40436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAT1"/>
    <dbReference type="STRING" id="387005.A0A183HAT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000459201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000459201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000459201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="220"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO40436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000459201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52717" checksum="49FD4B4D8AF8A0DB" modified="2016-09-07" version="1">MKREISSHSQRSSERFEKIHEFCKPLILSDDQLRRVMQEMHNKMEKGLSDQPGVKSCLKMLPSFVRAIPNGTEKGDYLALDLGGTNFRVLLIRLSGNEAEISGKIYGVPDAVMKGTGTLLFDHIAECLASFMEENDLKGANKLPLGFTFSFPVSQENLTSGILMHWSKGFSASGVEGKDVVEFLRDACNRRKDIDVDIAALLNDTVGTLMACAFKENTCQIGVILGTGTNACYMEKLSNCPKFKKFKFLEDKYPKEMIINMEWGAFGDDGCLDFIRTSYDMQVDEHTINPGFHLFEKMISGMYMGELVRYVLATLAKEKLIFGGDYDSISQPHCFPTKYVSEIEAEKGSDLLYQKTMQILEDIGVENVTIQDCEIVTYICSVISTRAAHLTAAGITCLLNRLQKPYVTVGIDGSLFRFHPNFARIMDQKIDQLLPKNLEYQLMLSEDGSGRGAALVAAVATRIRREARKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBE6</accession>
    <name>A0A183HBE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piezo_RRas_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4808</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003845">
        <property type="protein sequence ID" value="VDO41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBE6"/>
    <dbReference type="STRING" id="387005.A0A183HBE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000480701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000480701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000480701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="2">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000480701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27380" checksum="61869AF480DD6C95" modified="2016-09-07" version="1">MLFNPPVRYIKDLYPFMFLMDVLCFFVVSFGFSSFDYGGTGSVVRDISKIKFLSVVLIAAKYFFRFMAVPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAIIYNLKCARTYEKNFPTPRGVTKGAVIKYLMGVPVILGLILFIWLPLLSFSLLNRIGIVLPPNNVMLTIGIEGYPSIFTIEAQGIELEFLTDAEYFKLQNAFSEHYASSDAESILRARHAVAFIREYNPESIMVSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBV7</accession>
    <name>A0A183HBV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4969</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004057">
        <property type="protein sequence ID" value="VDO41627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000496801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000496801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000496801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552465" evidence="2">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO41627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000496801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40226" checksum="5B95220107641CE4" modified="2016-09-07" version="1">MILIFLSFVFELWNYTVHCSLQSNSLDDLGGNCLEGVLVNRCDEESSKLAAETEMLQVHSVSSSIVSPMSATCGTPNNAVSPAHLSASARCSTNSFYDSHSAAVTPQQSALTPSCDQSQRFAVTPALAVPASPIMVQENSLLCTRNASSSSSTSSIGSTTAMPPTSSQVGNNNINGGSSSVNDGNVYSNTTAVPALATVSSQQLHQPQQQQQYYPVTHFQQYHHSCHQQQQLLNLFNNGCHVSTNNATLSHMDNTRIYNGIEYPRFGHCYNQYNNHQNKSSIFPRFPSQTLVECSTTQQYDIHSMKYPNNGVAYYAQQPEMNMQQQTYQFQVPLFQPGYHHHHYHGSGNDPMTATQSSIYPMNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCM3</accession>
    <name>A0A183HCM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5236</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004394">
        <property type="protein sequence ID" value="VDO42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCM3"/>
    <dbReference type="STRING" id="387005.A0A183HCM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000523401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000523401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000523401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF126">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552481" evidence="6">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000523401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16048" checksum="E3561EE0C6B7A666" modified="2016-09-07" version="1">MKNLQMKAVLFVFLTILGICIGMRLQAVRAKGQLKCGDRPAKNVKVKLWDEDDGPDPDDVLDENETDGNGNFDLEGSTRELTTIDPVLKIYHDCDDSVKPGKRKIKLRIPGQYISPGSKARKAFDIGVLNLETIFPDEERDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDQ1</accession>
    <name>A0A183HDQ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vinculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5614</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004918">
        <property type="protein sequence ID" value="VDO43736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDQ1"/>
    <dbReference type="STRING" id="387005.A0A183HDQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000561201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000561201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000561201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000561201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60891" checksum="54796CC9FD2D82AC" modified="2016-09-07" version="1">MIFLGIQAIKAMTNEARNLSDLLPPAERSRLLDLCGEIDRLVDQLADLERRGLGNSPAAHAIRNQLRNKLHELADFMKKVVTDRVVEDFADISTPLKQFVDAVYAPPTMANREMNFEEKAHNLNTHSSRCANTALLVAKCGPCKNKKTVEAIIETANQVNAMTPQVINAGKIRLHNDSDSANQHFDNLRREYTDVLNKLRSYVDDAIDTGDFIRASEQAMRKYTSYCENAIRNNEPQQMVDNTSQIARFGNRVLMTAKNEADNSEEPSFVHKVNLAAQQLHSAIPPMVNQAKQVALNPRHGGSAQNWRDANEHLLSAVRQVGDAITGAGGSRPPSQNLLVESVPPKAPTSPVIHDRIYIREDIPTPPRPPPPVEISPPPRPPPPPETDDEEETRAFWERYPLPGASSQPILSAAHNLHQELRQWSSHENEIVAAAKRMAILMARLSQLVRGEGGTKKDLIDCAKAIADSSEEVTRLAVQLARQCTDIKMRMTLLQVCERIPTIATQLKILSTVKATMLGSQATIGPYGQPIDGKIEWHAFLSLTVLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDY5</accession>
    <name>A0A183HDY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autophagy-related protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005040">
        <property type="protein sequence ID" value="VDO44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDY5"/>
    <dbReference type="STRING" id="387005.A0A183HDY5"/>
    <dbReference type="WBParaSite" id="OFLC_0000569601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000569601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000569601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000569601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13831" checksum="19C0C5BDABD98528" modified="2016-09-07" version="1">MAYCIWLTVTIIFHIQTYRHWRILNQMHLLCFDWHSFLRDLFKKHASADNTDSGNSVRQISAISNNVLNMNYDDFVRHLQPEKGTIHVIGSYQHMMASTPLPNEEASSSLQMFDYDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEK0</accession>
    <name>A0A183HEK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5913</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005339">
        <property type="protein sequence ID" value="VDO44775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEK0"/>
    <dbReference type="STRING" id="387005.A0A183HEK0"/>
    <dbReference type="WBParaSite" id="OFLC_0000591101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000591101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000591101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000591101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30202" checksum="4B691263F21F2C3D" modified="2016-09-07" version="1">MNARMRPASTDPMQTLSTVSSSSSVTTSNNDIILRNDITGSKSSALTTQHSVVPHIKLPESNIDMSRQIPPLSDSGRSKHSSVDLPYRPRASVEPFQINQSKPFVDTRYESSSCPPLNKPFSVSTFGKDRANFTVLNRNSSPSPPKDPYPTAENTFDNKAAKLDERTFDTIDHLNKNISSSASEIVEKHQSQQPAKNTMMKSSSAAILGDEQLASNLIDKTKLTRADQISIRPDTLRAAKRRLENAFFERERERNLNLELFYYLPQYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEQ1</accession>
    <name>A0A183HEQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5964</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005417">
        <property type="protein sequence ID" value="VDO44952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEQ1"/>
    <dbReference type="STRING" id="387005.A0A183HEQ1"/>
    <dbReference type="WBParaSite" id="OFLC_0000596201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000596201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000596201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF114">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000596201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39061" checksum="2867997F52400B15" modified="2016-09-07" version="1">MILMDGMINYLIRRLVEEGIMGCINFILLSDHGMQQMDITKSVVTTNFLGPEFNNIFFPGVVARIEINQTAHSSQNDEDNIINNIISKMECQHGNNYVAYRKDLVPVRFHYAGSPRMGDIIIKGRPGVCIFLTEKEKESYKLLGDHGFDNRLVSMRAIFIAVGPDIAQKREINEFQNIELYNLFTHLLRIDAAPNNGTNGTLFTVLRNPPNFPLTAIDYPPDQCTDQINIKACSSSHDCPLMDDIHHNCPRTLHSFVNAAYDFTGELCSLQLCDAIVYFDKDLQRTVMVEGILKNTMWMQEAKENCIAYIDNVKQTNSCETPKNENFTLISLFGNLGNSFFYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF04</accession>
    <name>A0A183HF04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6066</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005561">
        <property type="protein sequence ID" value="VDO45285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF04"/>
    <dbReference type="WBParaSite" id="OFLC_0000606501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000606501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000606501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000606501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31652" checksum="8EACFDA09DC492D6" modified="2016-09-07" version="1">LDESNHGVISSPPIVEPGSSSPSAPESPILRATDVEMKEDESKTAQNENEDMQVMKNTVHSINNVSQDIGKVASCAVEVEYSEAQNSFNFAIPCAETSMEMEPCSSASIFSENKMKKSMEKWVPIKWMPKIAVNKETYVEHIMASFLGELRLARNDILIQPCSFTYPDYLTQQLGLNQYIHCMNMDFLADIITRYSVQDLSRWRTCLVCRPRLLEDETIRAQLGGTLNATSSALGRFVQSISSSDSNQMVQQLLTFCLDFETGLICKIFYNLIFFPHANSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFF9</accession>
    <name>A0A183HFF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005794">
        <property type="protein sequence ID" value="VDO45825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFF9"/>
    <dbReference type="WBParaSite" id="OFLC_0000622001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000622001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000622001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO45825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000622001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3362" checksum="FB1CC46B40750631" modified="2016-09-07" version="1">MAKMERAGKAGVGAGDRRKRRGRRKLNSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGC7</accession>
    <name>A0A183HGC7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cation transport regulator-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6540</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01006279">
        <property type="protein sequence ID" value="VDO46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGC7"/>
    <dbReference type="STRING" id="387005.A0A183HGC7"/>
    <dbReference type="WBParaSite" id="OFLC_0000653801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000653801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000653801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000653801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18383" checksum="A30754CEE53A7307" modified="2016-09-07" version="1">PGRTVTLVPDEKGSCWGLAYEVAEEQASDTIKYLDVREKAGYLRKEVMFYPDNGDPFFPINVYLAAEEQNPYFTGPTDEESIVHSILKARGLSGTNIEYVLRLAECVHRMAPHINDEHLFAIEKKVVEECRQLNIQDDYLANYLNHHQKNRTESHNKTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGN7</accession>
    <name>A0A183HGN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006447">
        <property type="protein sequence ID" value="VDO47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGN7"/>
    <dbReference type="STRING" id="387005.A0A183HGN7"/>
    <dbReference type="WBParaSite" id="OFLC_0000664801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000664801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000664801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000664801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6776" checksum="A818605ABD8AA94F" modified="2016-09-07" version="1">MVLARDPIDFDNKYKDEVKTFLENQRFWHSSFSFKNTALFLNTTDCFRTNQYNIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHN1</accession>
    <name>A0A183HHN1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6992</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01007009">
        <property type="protein sequence ID" value="VDO48775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHN1"/>
    <dbReference type="STRING" id="387005.A0A183HHN1"/>
    <dbReference type="WBParaSite" id="OFLC_0000699201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000699201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000699201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO48775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000699201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16412" checksum="6D3B1264D8762980" modified="2016-09-07" version="1">MDDYKKISEVGRGAHSVCWLCKRKNDIFRRKVVIKTMDLEGLTQEKQNAIINEVTLLKRLHHPHIIGYYESFKIEKSFSIVMEYAEGGTVDKMIAERGGIKFLESIVLNYFTQVVFANKLGNYLKNGIKECRCIYPKSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI97</accession>
    <name>A0A183HI97_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS7209</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01007370">
        <property type="protein sequence ID" value="VDO49831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI97"/>
    <dbReference type="STRING" id="387005.A0A183HI97"/>
    <dbReference type="WBParaSite" id="OFLC_0000720801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000720801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000720801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="72"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO49831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000720801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26203" checksum="7A4C251EAF0F49AB" modified="2016-09-07" version="1">MTSIEKLEDDIELRLMRTQQVKNSLLQFAGIADSVVPADDGTFQDDILLTVQQSNQLINSINNPKIRKKRQSLFLDDLPNEKWNVTLPIKYVFDSSLELSDEELVMKALNEIESQTCIKFELARIQPSESHLFYVKIFESDLCGLSYIGRVEDVNPIYLSFACNETIGIIIHETLHALGVNHQELRSDRDDYLTVNWENINPKLYDSFAVSDSNKFTRLKCFIFFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIR4</accession>
    <name>A0A183HIR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7375</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007673">
        <property type="protein sequence ID" value="VDO50703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIR4"/>
    <dbReference type="STRING" id="387005.A0A183HIR4"/>
    <dbReference type="WBParaSite" id="OFLC_0000737501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000737501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000737501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000737501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33679" checksum="DF322616BAA7C5B8" modified="2016-09-07" version="1">VIACDSPLTEKKLCSKADVFVNIINESNRFILSVLNTDPRHLKTVEREIAKILREFTNPCKLLLLETMEENQDDIKKSKQVDMYWYAVNPMTKRSCKIEEYSKLFDNSTVRTVAAKLKPRFVIGEIRDNVKSVVGENVLFLTNFKTASVGIVITMLAVMIVLAMTIAVGALIGICAICLCYTRHSKHEYPNINQIPKFGTIFLPNPPVGNSHDMLYETQMLEMPIGEEDSIMKPIGNGGGISHGILCSKSYDTDQDQSYQNYAHDVLIGGRKFPAEENTYAINERNRPQSQKNKYVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIS3</accession>
    <name>A0A183HIS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7385</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007684">
        <property type="protein sequence ID" value="VDO50749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIS3"/>
    <dbReference type="WBParaSite" id="OFLC_0000738401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000738401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000738401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000738401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17542" checksum="0EF78FBA75182AB5" modified="2016-09-07" version="1">MDPLTLLVAFLPWKRFIIIIIIIITTTQRIGTKREVLWGREKERYDVSPISLLWLFNFLISIAEEEQDVRQKSCFPCRILLKVNYTLFGLGLTMECSYSLIIISRILNQKIYFILTCGSNFIRHYYHDYGKITIQQMIDWSFPPATRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HL93</accession>
    <name>A0A183HL93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cadherin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8255</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009188">
        <property type="protein sequence ID" value="VDO54805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HL93"/>
    <dbReference type="STRING" id="387005.A0A183HL93"/>
    <dbReference type="WBParaSite" id="OFLC_0000825401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000825401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000825401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056448">
        <property type="entry name" value="EGF_Hmr-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24613">
        <property type="entry name" value="EGF_Hmr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin-related hmr-1 EGF" evidence="2">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO54805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000825401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21146" checksum="59C3449D3B45A077" modified="2016-09-07" version="1">MKNDDSSSSDSSRTDSDSIISVKQSKGVESGCSQRKTCANMGFTYCGGSFVCVDFWKGPFCTCPEGAQVLLGANGELVGCGETLAVSSLGISSPAIILILICLILLIIMVLMMVVYTRRHTPPFEPVRPEELNRDNLRPYDVEGGGEADNDQYNITNLRKPVIPIEENGVNGYAHPAYPVQRTPIGLKFKTFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLC1</accession>
    <name>A0A183HLC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS8283</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009232">
        <property type="protein sequence ID" value="VDO54937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLC1"/>
    <dbReference type="STRING" id="387005.A0A183HLC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000828201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000828201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000828201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO54937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000828201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17072" checksum="359959C31A59083A" modified="2016-09-07" version="1">MKEKCKLFLNICHCAQLPPPEDLSEDEVAKLLDSSDPSRYRIPLCVGDVEVVSDRKGEDSVKIDVIVNSTFYLMQLEKSEFFRQLLLLVVSEAIEKKHDIKIDVKGAIRLKNRKCIGDLSAQKIRKKPREAFIREVESVNQSEEQLPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLW2</accession>
    <name>A0A183HLW2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS8476</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01009618">
        <property type="protein sequence ID" value="VDO55847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLW2"/>
    <dbReference type="STRING" id="387005.A0A183HLW2"/>
    <dbReference type="WBParaSite" id="OFLC_0000847301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000847301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000847301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO55847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000847301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37146" checksum="87AC3597A3C17565" modified="2016-09-07" version="1">MTYHSDTIGESKRVIESEEKSNELRTRSDFIFLNEVGEGSFSTVYHVKERNTGREFAAKVCFKKQIIREKKIDYIFREKEALIRLSNSGGKHPFLVQIMCTFQDTENLYIIMTLAKKGDLLKLMRKSGGKFNLNLTKFYISEIVAALEHMHSLKIIHRDLKPENILISETGHILVSDFGSAKILDHAKPNRQTDRPESQKRRSSFVGTAQFVSPEVLKGEPVQQACDYWALGVIIYQLLTGQHAFHDVAEYLIYRRIMNAAYKIPNDFPEIAASIVRKLLVVEVKDRLGSIESGGAEAVKKEAFFDGINWNSITETEVPRLPCDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLZ2</accession>
    <name>A0A183HLZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SMC hinge domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS8504</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009671">
        <property type="protein sequence ID" value="VDO55999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLZ2"/>
    <dbReference type="STRING" id="387005.A0A183HLZ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000850301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000850301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000850301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000001">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="6">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO55999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000850301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22804" checksum="CE644EE1D14DA6A6" modified="2016-09-07" version="1">MSRQGEQLSENIVSQSNLIDDEKKNLQNLEVQVRESKERLEKVTSELNNVSRQLSEAHGDTAESERNRKRNETIENLKRIFPDRVYGRLVDLCQPSHRRFQIAITKVLAKNMMSIVCDTDETARESIVYLKEQRLAPETFLPLSVLDVHPIKEKLRELTEPRGVKLVFDVIQCNNSVARKALQFACGNALVCETPEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNE4</accession>
    <name>A0A183HNE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wsv293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9002</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010632">
        <property type="protein sequence ID" value="VDO58335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNE4"/>
    <dbReference type="WBParaSite" id="OFLC_0000900501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000900501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000900501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552581" evidence="2">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO58335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000900501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9098" checksum="572E4997DF62D7AD" modified="2016-09-07" version="1">MDGYVASLNSKPALKCREFIMLISFFLTFFQSNLGDDESKDDSSENYVDNNINNDDVDETEEMNRMMGVLQQLLLNYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNH8</accession>
    <name>A0A183HNH8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS9040</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01010714">
        <property type="protein sequence ID" value="VDO58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNH8"/>
    <dbReference type="STRING" id="387005.A0A183HNH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000903901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000903901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000903901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000903901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22674" checksum="1CCCBF4EE92F267E" modified="2016-09-07" version="1">MGSRGEYGCSVDELRTLMEYRGTEAREKLDAEYDGIEGLCRRLKTDPNNGLPQDKDELDRRRAVFGANEIPPHPPKSFLQLVWEALQDVTLIILLVSAVVSLALSFYRPPDDGLGAGSDDSEHEAGWIEGVAILISVVVVVLVTALNDYTKERQFRGLQAKIETEHKFAVIRGGNQIQIVVNELVVGDIAQIKYGKFLNICGCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNK7</accession>
    <name>A0A183HNK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARS2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS9068</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010754">
        <property type="protein sequence ID" value="VDO58581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNK7"/>
    <dbReference type="STRING" id="387005.A0A183HNK7"/>
    <dbReference type="WBParaSite" id="OFLC_0000906801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000906801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000906801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO58581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000906801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18868" checksum="5A4CA0C7FF73B196" modified="2016-09-07" version="1">MLIARLDRIIIYLRIVHSIDFYNHGEYPNEDVMPNRCGMMHVRGAPPSASQWGTDDNGKTLVAQKFVTDFIAGFNNRIETALMNETSLNESELNSLGRKDIEKEVESFITANCVELAKDKWLCPLSGKKFKGPEFIRKHLTTKHGEKLDQVRQEVHFYCLRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNQ4</accession>
    <name>A0A183HNQ4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS9116</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01010856">
        <property type="protein sequence ID" value="VDO58771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNQ4"/>
    <dbReference type="STRING" id="387005.A0A183HNQ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000911501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000911501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000911501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000135">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO58771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000911501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21543" checksum="E2972B660AD093FC" modified="2016-09-07" version="1">MHFCNGTVPIWALGRFGSPINLPEICVDVFLVVVLFEAAFRMSFFGDVQAQRDMEQMQAVRDQADWLLTNIIPQHAIDSLKLSTRYSENHALTAVLFATITNWNEMYEETFEGGREFLRVLNEIIGDFDELLDRPDFSQVEKIKTIGPTYMAASGLNPDKRRSALHPYEHLYQVSDFTKVLLNFQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNW7</accession>
    <name>A0A183HNW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS9177</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01010989">
        <property type="protein sequence ID" value="VDO59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNW7"/>
    <dbReference type="STRING" id="387005.A0A183HNW7"/>
    <dbReference type="WBParaSite" id="OFLC_0000917801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000917801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000917801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000917801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23462" checksum="35A7BECDBF9C3A45" modified="2016-09-07" version="1">CPFGTYGKKCAQKCSCIHGCDPRTGACLQCPPGRSGVLCEQSCPFKMWGDKCMNHCDCAESSECDSIDGSCQCYNGFTGVRCNRACPRDKWGLNCSQTCNQCRNNGKCDPVDGECRCPAGFMGENCELSCGMDRWGMDCMKECKCASDRKLCNPVTGICHCAPGLMGDLCNRYCPEGSWGPDCAFRCSCKMENSKCQATSGNCICHPGFTGPQCDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPA9</accession>
    <name>A0A183HPA9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9317</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011296">
        <property type="protein sequence ID" value="VDO59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPA9"/>
    <dbReference type="STRING" id="387005.A0A183HPA9"/>
    <dbReference type="WBParaSite" id="OFLC_0000932001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000932001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000932001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF89">
        <property type="entry name" value="POU DOMAIN PROTEIN 2, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="285"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000932001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42314" checksum="B2590EA47C74CBBB" modified="2016-09-07" version="1">NNNNNNNNGTNDNGTIGTSNYTQVIKPTCEAFQELSERWPPSQPPLPPPSLSLPPTVTMPQSVLQPYQPHATPFQLLFPPPQPDWTTYHEHHQHHIQQQLLQQHHSQQQQQQHQQQQQQQQQQQHQHHQQLSLMSIPQVIPSHLGNTGIMEMKQEPERPDVIQRLSAAAPSSWPYAFAQEDLPLSSSQLADETDSTCSEDLEAFAKTFKQRRIKLGYTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLYKWLEEADSTSSSPNSAFEKMTGQGGRKRKKRTSIEVQVKSRLEYHFQKNPKPNAQEIAQVAMELQLEKEVVRVWFCNRRQKEKRMTPQYGQELLLNPNNYPPDTFVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR34</accession>
    <name>A0A183HR34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mersacidin/lichenicidin family type 2 lantibiotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012740">
        <property type="protein sequence ID" value="VDO64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR34"/>
    <dbReference type="STRING" id="387005.A0A183HR34"/>
    <dbReference type="WBParaSite" id="OFLC_0000994501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000994501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000994501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000994501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10363" checksum="4EF51DF8BAA42D71" modified="2016-09-07" version="1">MSETLENIKSSIERWWTAVNADKRPKPNPARMVTVEELPMYPDETPYYKEVQELPMPVQKEMALLRQAALQRFGDLGVNFSGQIATFGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRJ2</accession>
    <name>A0A183HRJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Overexpressed in colon carcinoma 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10102</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013124">
        <property type="protein sequence ID" value="VDO65832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRJ2"/>
    <dbReference type="STRING" id="387005.A0A183HRJ2"/>
    <dbReference type="WBParaSite" id="OFLC_0001010301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001010301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001010301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO65832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001010301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9462" checksum="F6B258F5FB0C78E4" modified="2016-09-07" version="1">MSGCSWNENGEELQLNGSDDINENCCHRRAVSSGEPSLDGSVDEERAALSDSDLAGVARIQVIFCYSLTRSFRLEKKKSSMIGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSQ9</accession>
    <name>A0A183HSQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BPL/LPL catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10520</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014100">
        <property type="protein sequence ID" value="VDO69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSQ9"/>
    <dbReference type="STRING" id="387005.A0A183HSQ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001052001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001052001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001052001"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001052001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10892" checksum="77ECE8B7519F73C1" modified="2016-09-07" version="1">MSRNFGILKQNAKLFISRSQNIFENLAFEEWLLRNYKPDEEVESMLIWSNKPAVVIGRHQNPWMEADINYLRCNNIELARRHSGGGTVYHDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSY8</accession>
    <name>A0A183HSY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10598</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014306">
        <property type="protein sequence ID" value="VDO69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSY8"/>
    <dbReference type="STRING" id="387005.A0A183HSY8"/>
    <dbReference type="WBParaSite" id="OFLC_0001060001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001060001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001060001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001060001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9176" checksum="D0BE2C3293305FE9" modified="2016-09-07" version="1">MRPQLDDDAANYKKRQQEAENLRRVAFYGVALSTIASLICALSVPMFYNYLQHVQSVMQSEVDFCKSRSSNIWREVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT93</accession>
    <name>A0A183HT93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10706</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014563">
        <property type="protein sequence ID" value="VDO70631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT93"/>
    <dbReference type="WBParaSite" id="OFLC_0001070501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001070501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001070501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001070501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8245" checksum="7133E950661EB5C4" modified="2016-09-07" version="1">MSTVLLWWGCCRRSIQHDKEFHYLSVTSDGVTNALGNSVTRTSKTLPDDVPFLSKSKSIPHIAVINFSILVVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU22</accession>
    <name>A0A183HU22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA_lid_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10983</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015290">
        <property type="protein sequence ID" value="VDO72872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU22"/>
    <dbReference type="STRING" id="387005.A0A183HU22"/>
    <dbReference type="WBParaSite" id="OFLC_0001098401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001098401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001098401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001098401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9372" checksum="3328AB279962453C" modified="2016-09-07" version="1">TILDILRYEILPQLRVHEFFQVDIDKFVAKFEKYVKEGSSLEVWDVMLESEPGSDWNRFGFIVDMDRANKIFNRKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUJ5</accession>
    <name>A0A183HUJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS11154</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015746">
        <property type="protein sequence ID" value="VDO74279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUJ5"/>
    <dbReference type="STRING" id="387005.A0A183HUJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0001115701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001115701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001115701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552634" evidence="2">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO74279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001115701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24434" checksum="D022497D8601F935" modified="2016-09-07" version="1">FFFFFFFFFFFFFCRFEFPALLNLNAFIEDGDKKEPQDFLLHAVLVHSGDFHGGHYVVFINTNLGGPPKWCKFDDDVVSRASVRDAIEANYGGDDPDLPGKSFTNAYMLVYIKKSSINDVLCPVTEEDIPRHLRLRFEEEKSADAKKKKEKLEAHLFTELIVILEEHMYSYSGFDLFDPKILDEARRLKVEKKMTIDQLYTLFAEEFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUJ8</accession>
    <name>A0A183HUJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015755">
        <property type="protein sequence ID" value="VDO74304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUJ8"/>
    <dbReference type="STRING" id="387005.A0A183HUJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001116001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001116001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001116001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO74304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001116001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15804" checksum="132C2F4525BAEA91" modified="2016-09-07" version="1">MAMKNEKQEGEEKGRKRWQRLGPNAYVGWRTELLAHLKDSLEGNEITELRTRLLLAIVSRLPLNPRSGLEGHSKQIAEKLADYLKNFLSSYLTAQISFSDAQILLELPCERCNEEENISEDEKDDNKFCKRRQRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV64</accession>
    <name>A0A183HV64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS11380</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016376">
        <property type="protein sequence ID" value="VDO75999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV64"/>
    <dbReference type="STRING" id="387005.A0A183HV64"/>
    <dbReference type="WBParaSite" id="OFLC_0001137601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001137601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001137601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF11">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO75999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001137601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18450" checksum="6D9FBE749FE99375" modified="2016-09-07" version="1">KGKDADSGTYYCVAKNKYGEVWSREASLKIAMLRDDFRIRPRPLQAVIGNRAVLECSPPRGFPEPVVSWRKDEQDLRPQDEDGIVLHPSGNLVIEKVQRSDAGFYQCVATNMVGERLSNPARLSVYEKPYFLVIYIIDNHYYSKNFDWSDTLSVLLIIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVT7</accession>
    <name>A0A183HVT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase-3-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11597</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016945">
        <property type="protein sequence ID" value="VDO77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVT7"/>
    <dbReference type="STRING" id="387005.A0A183HVT7"/>
    <dbReference type="WBParaSite" id="OFLC_0001159901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001159901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001159901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001159901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19025" checksum="B0BF87FDC540FFFC" modified="2016-09-07" version="1">AIAKSAKKRKHFIESAIAFIRKYKFDGFGLDWEYPIGVAKEHGKLVKEMKAAFVEEAKNSSNEQLLFTAAVSAKKHAIDQSYNVRLIGKHFDLLFLKSYDFHGSWEKNVDLHAKLRPTKNANNVDFPRRYLPTKGGNSVELPGRYLPTKGKDSVELPGRYLPTKGKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW34</accession>
    <name>A0A183HW34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">OFLC_LOCUS11694</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01017227">
        <property type="protein sequence ID" value="VDO78509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW34"/>
    <dbReference type="STRING" id="387005.A0A183HW34"/>
    <dbReference type="WBParaSite" id="OFLC_0001169601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001169601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001169601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDO78509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001169601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16248" checksum="284CE047AA542A0B" modified="2016-09-07" version="1">MEKECPFWPDDRMCMSKECGIGYCDDEVPSGLKQPVTISVIGGVDSTCKKEESNAFDPLDTTLTEGDRQQLNDMDWHDENQDKFCDFEDEESADMHYVDLSRNPERYTGYKGDSAQKVWTCIYQENCFKLVENWFFYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HW90</accession>
    <name>A0A183HW90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bestrophin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11751</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017411">
        <property type="protein sequence ID" value="VDO78939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HW90"/>
    <dbReference type="STRING" id="387005.A0A183HW90"/>
    <dbReference type="WBParaSite" id="OFLC_0001175201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001175201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001175201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001175201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9631" checksum="D61C7E7D303AF328" modified="2016-09-07" version="1">MRLLSQSVGKPPIFVEKLILKWWKICLLSELLALVYIGIIIQPEYNEHTKISENALLPALVTERFTYSQRISTFLKELRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWJ9</accession>
    <name>A0A183HWJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017668">
        <property type="protein sequence ID" value="VDO79781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWJ9"/>
    <dbReference type="STRING" id="387005.A0A183HWJ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001186101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001186101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001186101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO79781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001186101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14762" checksum="AF410EE6865610C3" modified="2016-09-07" version="1">MSIICESNWIDTFWLTKVFDELLSHIFTQNVLAEVVGNLKNQLIKAYAEMNDFNELIWENMPMNFWIRCGGAVVFDHEPLLNLWDKVCSSADCGIIKLLSTVIYNYLIELKPYLPRLQVILSFARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXU3</accession>
    <name>A0A183HXU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12300</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018928">
        <property type="protein sequence ID" value="VDO83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXU3"/>
    <dbReference type="WBParaSite" id="OFLC_0001230601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001230601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001230601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001230601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18786" checksum="A09D954F40A0FFCD" modified="2016-09-07" version="1">MNRSLNAAALNPILAQPAAMLSLQQQLSKHISSTLAQPNVKSDANCAIRQHEIRRTETTSRAQLSFDRKRAIDCASNSSSISATPKRSKLLIDEILNLKTNETYPADSHETVPDGASQHESFSSPSISREQSSEPNLTKQDEKASMSDNCVLTDTFVVPADSSNSRRSSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYB1</accession>
    <name>A0A183HYB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS12473</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039850">
        <property type="protein sequence ID" value="VDP11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYB1"/>
    <dbReference type="STRING" id="387005.A0A183HYB1"/>
    <dbReference type="WBParaSite" id="OFLC_0001247401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001247401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001247401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20795">
        <property type="entry name" value="C1_PKD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000021">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001247401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15962" checksum="E84D5AEBCC22BC29" modified="2016-09-07" version="1">MCRHALYVHSYKSPTFCDFCGELLFGLVKQGLRCQGCKLNYHKRCVSKIPNNCSGYKQQLLPFYLLSLQDSTAKTSSRPPPSPFDEINNTSIKKQANSAMILKIKLFHFKVPPDISITTTDDISSYGRPVSPVNQNVRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYL9</accession>
    <name>A0A183HYL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAR1-RELATED SEQUENCE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12581</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039874">
        <property type="protein sequence ID" value="VDP11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYL9"/>
    <dbReference type="STRING" id="387005.A0A183HYL9"/>
    <dbReference type="WBParaSite" id="OFLC_0001258201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001258201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001258201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001258201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21961" checksum="D73D914A42F8AFE3" modified="2016-09-07" version="1">MVVLSLILIRSWPSELLIILEANELKRMLIGYGSKPGAFVKPSPTFPTFSTATLSPTYGPLPLFYPFFLPVKRSEKSDNQWLFFMNNCKQTFKKTKVCDQETKAIMMSIATLHGSVTSSMNSYDSSCEMKCFAEEKNQAPYGLPFGRMPSGPMDARSMSPTYAAFVMQQAAQTMSPTFEMYRNFPFGPASPSSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ54</accession>
    <name>A0A183HZ54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039927">
        <property type="protein sequence ID" value="VDP12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ54"/>
    <dbReference type="WBParaSite" id="OFLC_0001276701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001276701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001276701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001276701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11763" checksum="F1DF6D92BDECBB6D" modified="2016-09-07" version="1">MDVNTVPRLVSLENSCPKPSMIKSRAVHDSNIDDPFVSFTFQPNLTNSELNCKFMVYIAFLIMTSYPFFVMSCPSSHSVSTTNTNEPTLERNVHMREYQGKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ81</accession>
    <name>A0A183HZ81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12793</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039935">
        <property type="protein sequence ID" value="VDP12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ81"/>
    <dbReference type="STRING" id="387005.A0A183HZ81"/>
    <dbReference type="WBParaSite" id="OFLC_0001279401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001279401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001279401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001279401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20485" checksum="6A1BB9CFE19E0000" modified="2016-09-07" version="1">MGVKSQNTNNEFWSLYSFADRIDIQLMITGLILALIQAILLPFVWLVMGDFVTVSIVREQYKLEKEKHFELFNSSKTDGLSSNNSFDPFNLTEFLDALTRQSQMDAQFEYSATPAFVIMLSLSVATFIAAFFQRLAWEVSGIRQVFRVKKAYIRKLLHMDVAWLESRHSGQVASMLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZI8</accession>
    <name>A0A183HZI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAGUK p55 subfamily member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS12900</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039968">
        <property type="protein sequence ID" value="VDP12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZI8"/>
    <dbReference type="STRING" id="387005.A0A183HZI8"/>
    <dbReference type="WBParaSite" id="OFLC_0001290101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001290101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001290101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="297"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001290101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55121" checksum="0A1FF0E43F4F6E63" modified="2016-09-07" version="1">MGKRRFSRVEGIYLKHSAVRGTFRKCPETWPESFPLAHFYTEISEKVDRVLSYKQILQHYFVVCNETVKEDPETGVKRRTVVTERVVTTKTFHVIPINGDVDQSVTVDETEVSHADKSKMFRTAELTLRNNGISSPLLSETSSIPNTRIVRLSQNPFRGIDYDRVGDLIIITRVKPDSIAKDIRASDAIVEINGIPVTQIKQLTELKDSSVLKIMPTPLHQGPSVYYRAISDYDGSHDNRVPTNFNGLSLKKGDVIQAFSKDSNWVQGRKVNDLNQTGLCPVSILGEQISMLTPYGRRVVVLLGVPGVGRRTLKAMLLAHLPQYFAAATPYTSRVPKPNELEGREYYFRTKEEMLERIRAGDMIEWGELDEQFYGTSVETIRSCIRSGRVCLLDCGPQALQHLYNAEFMPLVVLIAPPGINDFRQINKFRRRPFTEEQMEAFIRENKELMESSYAKMFHIVLVNRNLDITFRRSFFIYLLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZJ6</accession>
    <name>A0A183HZJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12908</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039971">
        <property type="protein sequence ID" value="VDP12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZJ6"/>
    <dbReference type="WBParaSite" id="OFLC_0001290901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001290901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001290901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001290901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10019" checksum="419316143DFAC66A" modified="2016-09-07" version="1">MRVCRQIHSTTCPAVALHAVYHLFIPIFTVRHRQSNDKHSLLPLQHRHSEHCLQLVLLNLPYSFESFTVIFNRSEQLDFIFSSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2W7</accession>
    <name>A0A183I2W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS14079</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040583">
        <property type="protein sequence ID" value="VDP15438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2W7"/>
    <dbReference type="STRING" id="387005.A0A183I2W7"/>
    <dbReference type="WBParaSite" id="OFLC_0001408701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001408701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001408701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10569">
        <property type="entry name" value="FERM_C_Talin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17089">
        <property type="entry name" value="FERM_F0_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17090">
        <property type="entry name" value="FERM_F1_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000007">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000028">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015224">
        <property type="entry name" value="Talin_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036476">
        <property type="entry name" value="Talin_cent_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09141">
        <property type="entry name" value="Talin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109880">
        <property type="entry name" value="A middle domain of Talin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP15438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001408701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68603" checksum="56C0410D17D3D649" modified="2016-09-07" version="1">MGVITLNVVWSPQGDEQSRLKKAMQFESTTLVFDACKIIREKVSGNNINPKEYGLFRLEEDPTKCVWMENGRTLEYYLVRNGDTVEYKKKIRPLKVRMLDGAVKTVLVDESQPVGEIMVAVCSKIGISNHEEYSMVRQSLDHDWRSTLTLKEERRGKSEERGLGFGTLGRNKEKKMEQLRAKLHTDEELLWLDHGKTLREQAIADDETLILRRKFFFSDTNVDCRDPVQLNLLYEQCKMGVLQGNHPVPRDLACDLAALQCQIQYGDLQEHRQRTNFLDLREILPKEYVKSKDNEKRIMDAYRELAGKSELDAKSKYVHLCRSLLTYGVTFFVVKEKMKGKNKLVPRLLGVNKECVMRMDEKTKEVLQEWPLEQVRRWAASPKTFTLVKDFGDYQDGYYSVQTADGEKIAQLIAGYIDIILRKKRTFDHVGIEGDEGSTMLEDVVAPARATLVAHGQIGEGFAHEGSVAIPGVLRTHGGSVPGQRGMLNGAQYGAVSGQILQQQLTKRKEKERILQGQRPRVIDSQERAQRALIGTIEASIRAVEAAEEEIKKPVEIQIPRFIDDPTSRRWMETKVEVEKQKASFCLSFLKKYVFVYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2Z1</accession>
    <name>A0A183I2Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040600">
        <property type="protein sequence ID" value="VDP15499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2Z1"/>
    <dbReference type="WBParaSite" id="OFLC_0001411101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001411101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001411101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001411101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5368" checksum="9D0F2E68C3884B13" modified="2016-09-07" version="1">KTLRIIFGYFKAFNYKFLVIVIKKKEKLLKGQKIESNKTHCCLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3J4</accession>
    <name>A0A183I3J4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="13">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS14307</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040752">
        <property type="protein sequence ID" value="VDP16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3J4"/>
    <dbReference type="STRING" id="387005.A0A183I3J4"/>
    <dbReference type="WBParaSite" id="OFLC_0001431401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001431401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001431401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001431401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13337" checksum="01714D20BC3A16FB" modified="2016-09-07" version="1">MTAIGVPIKILHEAEGHVITLETTIGEVYRGKLNEAEDNMNCQMSEVTVTYRDGRTHHLDNVFIRGSKIRFMILPDMLKNAPMFKNIGRAQKGAVGMGMGDNRDGRGLRGKLFMLAGIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3U9</accession>
    <name>A0A183I3U9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">OFLC_LOCUS14411</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040833">
        <property type="protein sequence ID" value="VDP16939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3U9"/>
    <dbReference type="STRING" id="387005.A0A183I3U9"/>
    <dbReference type="WBParaSite" id="OFLC_0001441901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001441901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001441901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF32">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP16939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001441901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="413" mass="48091" checksum="31711DBA220C96E8" modified="2016-09-07" version="1">MDKLSIVIESLTKPRYEEDSIDRLNYHVTTFILLLAAFTIIAKIRNCVLQEYGGDPIQCWLPAELASQKSWEQYAEGYCFVENTYYIPLEQNIPQSAKHRDEKLITYYQWVPFTLMLQAMSFVLPHVFWRMLNWTSNVQTRAVISMADSVRQMDPCSDEAHDTVDAIASHIYHADKSTKRLHKILKNYNLLTIFARIFKQSYLSTIYIITKLLFVTNATVQFWIVSLYLGGNGYELTKALMKQQTWQNTGLFPRVTMCDFKIRAMGNIHHHTIQCVLMANMFNEKIYIALWWWLLVVITVTIINLLYWLYVLNSITSSYRFLIELVKLGVSLQLNFGIDVGFTTVSSPQQPQEKMTNNLIQQFAEQFAGDTTLVLRLVTQNASELVASNIAARLFDIFAKKRYFSRYFSRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I414</accession>
    <name>A0A183I414_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040889">
        <property type="protein sequence ID" value="VDP17226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I414"/>
    <dbReference type="STRING" id="387005.A0A183I414"/>
    <dbReference type="WBParaSite" id="OFLC_0001448401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001448401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001448401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001448401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="505" mass="57766" checksum="E8DEC6E781314F7D" modified="2016-09-07" version="1">QFCRPFKTASIYVQSLALSSVSFLGAVKNAKLSLLPDGYKTEDKLPSSLSAGLPHFATGIWRNWGRDTFIALPGCCLVTGRFEDARNLILSYGGAMRHGMIPNLLDGGHGARYNARDAVWFWLYAIVKYIEMVPNGVEILKNTVLRIFIHDDTIYGHDLTEQCLADTMQETLMRHFNGIEFVERNAGPRIDECMQRTSKYQIFPGFHVKAYVDHNTGFICGGNLYNCGTWMDKMGSSEKAGNKGWPATPRDGAAVELQGLCYTVIEKLEELYQKKFYPYEGVFTENKEIWTWSKWANIMRNNFERFFYVTDDDSSKYVNRRGIIKDSYGSTQIYTDYQLRPNFSIALAVAPRLMNAEKAWHALQIAETELLGPLGIKTLDPSDYNYCPFYNQDDDSTKKTARGWSYHQGPEWLWVAMFFYRAKLSVAKVISVDKNDMTFYEEAKRFIRSRMGAYWEHLKCSTWASLPELTNANGTPCYHSCGAQAWSIGCLLETVDELYELHKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4F9</accession>
    <name>A0A183I4F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14621</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041012">
        <property type="protein sequence ID" value="VDP17911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4F9"/>
    <dbReference type="STRING" id="387005.A0A183I4F9"/>
    <dbReference type="WBParaSite" id="OFLC_0001462901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001462901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001462901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF1">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552768" evidence="1">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP17911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001462901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25489" checksum="6CAECDDDE1B629CF" modified="2016-09-07" version="1">MLWQFILAPLFIQQSAAQELKQCPYIPISGCCSLRWTSDCVPKHCFKYILAQCPERKTLMFKRNVKETNNLKRSPNSAFQGHPLPLCGTVELGYKPCTSRAVADKLFQSCCNIYVPKECRSMCVYETDQNATRELLISNFREKKCGLKYLSSILYCASQNRDNRKCCIHLDLNDPQLQVGSRCLRMCDPTGTAIEQITTEDATCLYNWNVIMYCHHSGIREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5B2</accession>
    <name>A0A183I5B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041362">
        <property type="protein sequence ID" value="VDP19611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5B2"/>
    <dbReference type="STRING" id="387005.A0A183I5B2"/>
    <dbReference type="WBParaSite" id="OFLC_0001493501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001493501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001493501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001493501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25872" checksum="BF5D524DDCC4CB0C" modified="2016-09-07" version="1">MPSPCCSRYVWIGISEVGVQKEWRGGVRAGVNHRGTAGETGRSWGKLITGDRAPKLSLRLAMIVLRLQHKLRPMRTVRWFYNEDFYVVNFPVDGVRRGEGMNSRYSDHDKLVVYASRQLMTILSVVGGKGPSPIEGEEPERASRSLYQSALTTEELGFFNEVKNFLGSTVNEQLLVQAIKSHGSHMQPHLSGNNVLNDVISLYFDKMESVDKPNKQVRFDEVIPLFNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5G1</accession>
    <name>A0A183I5G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS14973</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041433">
        <property type="protein sequence ID" value="VDP19829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I5G1"/>
    <dbReference type="WBParaSite" id="OFLC_0001498401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001498401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001498401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF65">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP19829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001498401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21053" checksum="8B59F8FAFF807C3E" modified="2016-09-07" version="1">MRSIWNESIRLGXXXPVGYVIASKKPSKICGPFGSQERFYSIIVQLLDRNLTKGLVDAIRYMISPGIVIPVLLLLLLTIYFLFALVRGLREANTDLTKQLLHERTEEKKRIFELAGGRKRSLTNNHDGTHPLHPLKSENSTDRTNKINNTTDHNHDVSPERVQKRSINDLHNYIPSLKYDYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5K3</accession>
    <name>A0A183I5K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041486">
        <property type="protein sequence ID" value="VDP20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5K3"/>
    <dbReference type="STRING" id="387005.A0A183I5K3"/>
    <dbReference type="WBParaSite" id="OFLC_0001502601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001502601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001502601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001502601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8377" checksum="304BF90515B95323" modified="2016-09-07" version="1">MAGNNIEVSALHSLSCTHVSKIDLRRNALKRTMRLTSLICCALTELDIRDNENLLELDLSNLHTIQVFKYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5Y9</accession>
    <name>A0A183I5Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P66_CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS15151</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041680">
        <property type="protein sequence ID" value="VDP20588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5Y9"/>
    <dbReference type="STRING" id="387005.A0A183I5Y9"/>
    <dbReference type="WBParaSite" id="OFLC_0001516201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001516201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001516201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP20588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001516201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="30884" checksum="491F2B9C8B2F33C3" modified="2016-09-07" version="1">IQEANIRKLTANVAQNGSGHAYKPPVAAVQNRSTSNSHSKASTSNASSRAVASAASAAAALMNLNLTPQQQQLLQNAAKSAALAAKETAAQRAAAAKLALRRQLEQQLLQVSLVFDEEKSFMGAAIDSYVVRVSEGPYLCEECGTDFTPVWRAIGADENSLNLYCDACVKAAQKKKLRQEHTALLRKAFNKVMEKEQELEKQIAEGKFETAVPSSSTPRSSTPATPPLNAAAVKTPSSSGASLSAPKASTSSASHQQHHTKSSSYKRPAATSSNTTAHAASQNAAAAAAAAALAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6U9</accession>
    <name>A0A183I6U9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15461</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042179">
        <property type="protein sequence ID" value="VDP21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6U9"/>
    <dbReference type="STRING" id="387005.A0A183I6U9"/>
    <dbReference type="WBParaSite" id="OFLC_0001547201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001547201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001547201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001547201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29401" checksum="C834F11E82C1295A" modified="2016-09-07" version="1">FATLSAKKASKELDVLQKQLKCFEEDYESKLDAVRHAEIGIKLAMEKVREGKQRLYEAVGIEDSANEAAETLEILKRTFISHAIPNTKEEVELEMAREQGKLDALHNEGEKKDIERFEKLTQKKESLIKEMATKQKDVSEWEDKINSLLEQWLLQLESLVTKLNQYFSSFFENMGCTGEVCLQKPDDKLDISKYGITVTAKFREDERLRQLTHQTQSGGERSVTTMLYILALQKLTVVPFRCVDEINQGIQVCGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I735</accession>
    <name>A0A183I735_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15547</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01042339">
        <property type="protein sequence ID" value="VDP22486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I735"/>
    <dbReference type="WBParaSite" id="OFLC_0001556001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001556001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001556001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP22486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001556001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30742" checksum="44BB411BCECB2E29" modified="2016-09-07" version="1">MAEDILYRIGSENSNMNMDFTAEIYKEALIMVENLCLQIANKVLNQLGMPSPNRSTAASFDMELHREQNYNIADLASYVSSNISKLMFEQKAIYDEIMQTVNKGIEKIFFLDASGGNGKTFLIKLILASIRFQNSIVLTLASSGISATLLPGERTAYSALKLPLNIQMIETPTCNISKTSDMGKVLQKCKLIVWDXXXXLPHATFPRHRTWVKYCKNANLLFDVQKIDRGSSSIIARFAWKHQIIWERINIICRRFQASIICNSSINTSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7K2</accession>
    <name>A0A183I7K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042698">
        <property type="protein sequence ID" value="VDP23403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7K2"/>
    <dbReference type="STRING" id="387005.A0A183I7K2"/>
    <dbReference type="WBParaSite" id="OFLC_0001572701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001572701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001572701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001572701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23632" checksum="C53D64230FB5D66C" modified="2016-09-07" version="1">MTAMNEWLNSAESYLGCLEHVSRIPETVEKQMNEHTNFQAEVSHYRELMTDLNSKGTKVQYYCEKKDAIPIKNLLVSAKHRFDKVASRCADRMKQLDLALQEARLYFVSHFQLVSWITSSFEWVNDQYAQTVSGDRLRIDLEKHRKFQHELTEQQAAYEATYKRGRALSEHAPREEQEGIDLMNEMLKEKWTQLVNATLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I831</accession>
    <name>A0A183I831_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15893</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043159">
        <property type="protein sequence ID" value="VDP24628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I831"/>
    <dbReference type="STRING" id="387005.A0A183I831"/>
    <dbReference type="WBParaSite" id="OFLC_0001590601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001590601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001590601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="2">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP24628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001590601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17456" checksum="F18AF7261547DD5E" modified="2016-09-07" version="1">MNASMHNFSEQQLRMRMVARLLRDELIMQLHTFFYLMPPFSHEVVDQSTTMDTLEDDNLHQLLSNAMLTTEIKTSVIHVYKTMLKQHPQQYVEDLLDLFLKFIPYLRGEHHIEDIMYRMNLERSSVMRVLDTFACVIAPFMRPEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8N0</accession>
    <name>A0A183I8N0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS16093</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01044024">
        <property type="protein sequence ID" value="VDP27079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8N0"/>
    <dbReference type="SMR" id="A0A183I8N0"/>
    <dbReference type="STRING" id="387005.A0A183I8N0"/>
    <dbReference type="WBParaSite" id="OFLC_0001610501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001610501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001610501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDP27079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001610501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11369" checksum="A9E5DFD3F8AF04FF" modified="2016-09-07" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VA69</accession>
    <name>A0A3P7VA69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005239">
        <property type="protein sequence ID" value="VDO44516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HEC7"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037201">
        <property type="entry name" value="CacyBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140106">
        <property type="entry name" value="Calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="232" mass="26851" checksum="C09E30B88869C681" modified="2026-01-28" version="1">MEERTELRRDLHELQNLRSIASRQMIKRMLDEKISELESKIKTLEAMNNVNECGDVPSLKQSRTEAVSSNTVPLATVKITNYAWDQSDKYVKLYLTIPEIHTVPQEQITVNFTESEVEVNVRNVSSKNYSLVIKGLLKAINPSSSSFKQKTDLLLIMMKKNEEENWKYLTKAEMQSKEKSTPKFDQKADPQESLMGMIKQLYDDGDDDMKRTIRKAWHESQTKKSADLDEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WFY2</accession>
    <name>A0A3P7WFY2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS6354</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005994">
        <property type="protein sequence ID" value="VDO46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WFY2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="197" mass="22603" checksum="0C7ED859F50B5E3B" modified="2019-02-13" version="1">MHCLSPNILLKNHFSYAPWCPACKDLQKAWHAFADWSKDLNINVAEVDVTVNPGLSGRFLVTALPTIYHVKDGVFRAYAGSRDKNDFINYIEEKKWTFYDPIPSYKYPSSPQMTVVAWFFKLSMFVRDRHNYLVDEVGIPSWASYSVFAGLTLTLGCILGFFIVCIIDRVFPTNDQFCKPEIKKSTKKDQKAKAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WYK7</accession>
    <name>A0A3P7WYK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013107">
        <property type="protein sequence ID" value="VDO65786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WYK7"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO65786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="87" mass="9004" checksum="5282CA60024A4889" modified="2019-02-13" version="1">MQAAVPAPSGGYPQRTIGASQPDEDLIAGVTAAFDSAHGPTTVAATDRLAVAASTSAFTEQQYRNMISSTGNAYKCEAKCHSLENEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XWH0</accession>
    <name>A0A3P7XWH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012713">
        <property type="protein sequence ID" value="VDO64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XWH0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO64547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="208" mass="24794" checksum="12A0810D2EB4B2E3" modified="2019-02-13" version="1">MFNIFESTYWLLIVLKFCYLDCQKYFSSFRIFLLVFYVRFWLNTDVKIIDARLGWIQKTFELSGDEMRQLIVTESRIIIYGVGPLERLVTMLNEELEFTKEQIKAILLEDPRVFMMESSALHATYNYLRFTMHLSNMQIAEWPLCLRFSIGAIRRRHEFLVQLHKADYDEGSPNYIPLSSLLQPSDQKFAVNVARTYLTVYNTFLKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y1B1</accession>
    <name>A0A3P7Y1B1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pao retrotransposon peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012674">
        <property type="protein sequence ID" value="VDO64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y1B1"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="53034" checksum="66F6B54BDFC190AF" modified="2019-02-13" version="1">MELLPAERNCTRFLWLRNIYGRVTEDNIVSYRFQRVPFGVISSPFLLSATLNYHLEANGSELASEIKKNLYVDNVILSADGTYEALKGYMEMKSIFKEASMNIREFLSNDRKFNEIIPEYDRAEVGTYKKILGLNWDPNKDVLQIILKPWKQQELTKRTILQFVASQYDPLGFLVPIMIQFKIFLQTLWKKNNSWDQLLSDEDELTWKNLINDWPENLKELSRPTIQFTNSSQIHVFTDASTLAYSAAVYAKQGTDTFLIYAKSRIASIKGMTIPRLELLAVLIGVRAAQFVLKQLDLETTQVTLWSDSKCALHWIRNHSRLQPTFIQNRVEEIRNAKFSFRYIPSDCNPVDIATRGLFPSKLGDNQQWWKGPKWLAGDESDWPLWEFNFKENDEEVNVITKTLKSTVTKGSLRLLDASPFSKWKKLVRTTIRILKFINLIIKEGSHGYKTFQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YNH5</accession>
    <name>A0A3P7YNH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003924">
        <property type="protein sequence ID" value="VDO41322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HBL6"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004757">
        <property type="term" value="F:sepiapterin reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051721">
        <property type="entry name" value="Biopterin_syn/organic_redct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085:SF2">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="268" mass="29475" checksum="4427461B6AB22698" modified="2026-01-28" version="1">MTFKGRKVLAVVTGASRGIGRETVLQLSKIVAKDSAFLITARTAAKLEVLKDEIKSGAEGIDVHVLACDAEKLNPGKILELQGALSSLIANSKTYDALLLVHNAGTVGDVTKRGVEISNSDDWHSYLQINFVSMVLINNSVLSTIPERVAPARYILNVTSLLAIKAFPSMAQYSVGKAAREAFFRALAVEEHNLRILNYSPGPVQTDMHNEIAKKSYDEGIRKSFQAQANSTEVNRRTLSPKETVEKMLSILEEDKFENGSRYDFFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YZF5</accession>
    <name>A0A3P7YZF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014459">
        <property type="protein sequence ID" value="VDO70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YZF5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="75" mass="8643" checksum="49031C7845380CEB" modified="2019-02-13" version="1">MCFFKVCQAIVTLTVNSIIRQPTGTFEARFGRRATRALVDWLRQNGHSYRSNINVIVADFVDENDFCNTMIDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B9C5</accession>
    <name>A0A3P8B9C5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase V1 complex subunit H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS15580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042399">
        <property type="protein sequence ID" value="VDP22682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8B9C5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDP22682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="267" mass="31087" checksum="0900D46E90152F96" modified="2019-02-13" version="1">MLYIIINDLKLSYTFSILSVLSGKTNFQLQYQLIFSLWCLTFNPTIAEKFPHTGAIQILGDILSESTKEKVKLCIFIFFLRTEEYVIRIILGTFRNILEKIDDRELERETALQMVQCKTLKTIELMDSKKFDDAELNDDVEFLNDKLHSSVQDFSSFDEYVSEVKSGRLQWSPVHKSEKFWRENAQKFNDKDFELLKILIKILEVQSDTLALKIEQLQGKQAVMKLLSADDPNVRYHSLLAIQKLMVHNWEYLGKQLDADNATATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8B9Y2</accession>
    <name>A0A3P8B9Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040275">
        <property type="protein sequence ID" value="VDP14130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794751at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="616" mass="68934" checksum="47F9376C236E0141" modified="2026-01-28" version="1">MDLTKYSAISVQHDHHQQQQQPGLNPQMSDLTSTDTSQVSHKSISQDSVLSSTASAIIPLPSTSCTATTKDFEPEDSQLSPKNNSASSLVQLLTSPNTTVLHRPTPIHPLASRLFTLATKTPALESNLEVPLDLSQSTAVRQQLLIKTEQQQQLKFLPTCANPSLNSNWIAIKFGAAVGPNRMSYPREFKLMVINYYYTNGQNKYRTCKEFQITKSMLNGWLQKIDKIRQSRPGSLKSGRSGRKPQFPDIEEQLFHLYHAHLGTGKKVGNRWIRETARNLAQQQCSEQELAGMCQFSERWLSNFKKRYRINLNRDWSSGNSSSGSLGSTESIGSGSSATNSIQQSPIKSDETAENESMDSDADSVLSDSLETLIDVEDQMSLDNPLSILTSGTFPNAQEHVQEILNKPGQLPIQAFYERFPWLCRKNQTGTEPGRRGRKVQFPGVEKVLFERLQEQQSKGERVSNRWLQQQARELALQICPEVLQEATKSARCLFSEHWLHNFKKRYGVTLKQTNRNVISPSKTSETLSPTTASQCDSSLTDDKNCISSINGTAAKPVTDLTTMLQLQNWFLAKYYSQEQGTHSATSLPQSAYRNTMVPLSSASVWYPASLTQCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C0E8</accession>
    <name>A0A3P8C0E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS12710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039911">
        <property type="protein sequence ID" value="VDP11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8C0E8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="625" mass="69639" checksum="8D3CBE5C543B196F" modified="2019-02-13" version="1">MIKNALFYSTQTGIISSWYDFAILITVFPVCHWGNTGHKGRWIGIGSFLMALGSFVCVLPHYMASPYRYDETQLNRSEHGQCTYRDDLVSDCSKHLSGSASYLNPYFLMFLLGQTLHGIGATPLFSIGTAYLDENVSQKASPVYLGKKIAIHSVVTSIGPVIGLFVGGFMLTIYTDFDRVDMSKVKLKDSSDPRWVGAWWLGFLGSAILAFITAFPILMFARELPEAKKHRLKDVNQVHAISQINDKDVILKGNLKYLPQAVWNILRNPTFVTTIVLGIFESIVINGFAAFMPKILEAILSTTPTKASYLSCQLFSAIVIFAAAAGVMLGGALIRQFNLQVSGMLKLIFVCHLIALILTPCFLIQCPSHDFIGINLNYDYQRIKGSTDNLHATCNANCYCTEKWNPVCHTGTGYTFYSACYAGCTNWVQNSSGTYWSNCACFDELISYASEIQYKDDRLQEGFCEKKCGYVQWIFLILLFLSVVASFATGIPSQQIMLRVVPFEQRTLGIGVHWTFLRLLGFIPGGVLFGMMIDTACVKWKEECGKRQSCLVYDSYRLSWTIMAVAIVCKLVSILGTILGYITYRPNDLDNNISVQTTDSRGPLSLTVNDDRPPDEMINSFDAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F0C0</accession>
    <name>A0A3P8F0C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040524">
        <property type="protein sequence ID" value="VDP15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2N7"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="150" mass="17587" checksum="DD409655125AA768" modified="2026-01-28" version="1">MSGDNLNDFYLRYYVGHKGKFGHEFLEFEFRPDGKMRYANNSQYKNDTLIRKEAYVGKIVVEELKRIIDDSEIMQEDDATWPEPDRIGRQELEILHNDEHISFTTSKIGSAADVNKSRDPEGLRSFYYLVQDLKCLVFSLIGMHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8F341</accession>
    <name>A0A3P8F341_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041143">
        <property type="protein sequence ID" value="VDP18499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP18499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="85" mass="9751" checksum="FEA7929A67437813" modified="2026-01-28" version="1">MFGAHPPTSSIGDKRHLLTASVQSSQSTRYALHRCACYSPPTKTFLVQYESRTWKNGKRVEKSDELETMRRLRLLVVISANLDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXX6</accession>
    <name>A0A183GXX6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2 10">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS86</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="UZAJ01000020">
        <property type="protein sequence ID" value="VDO24469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXX6"/>
    <dbReference type="STRING" id="387005.A0A183GXX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000008501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000008501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000008501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="11">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO24469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000008501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="669" mass="76708" checksum="85994FF51CCA3310" modified="2016-09-07" version="1">MSCCEKKGCLILSKCKCDYTPIEENIWKLCNKISASLEELNCCSVVFISNKNRMVPLWKQRAAAVGRDHVIWDYHVIMLYSKWGSVLIYDFDTTLTFPCDAEIYWIETFRPELNLDANYRRCFRVISSSDYLQHFSSDRSHMLETDGNYKAPLPSWPAIHDPDIGNNLDSFISMDSDLLKDISKVYDENSFSKHINELSRRFKLITLLLLKLNSEMAISFCYLFLVGRFEFRRAFTTSLPAKNIKQFCIDLAKRNLISSSHPSDLSSDDFKAVSTLPSVVYAGFDPTADSLHIGHLLVLTNLFRAILHGCHAIALIGGATAHVGDPSGHITDRVIVPDHEIDQNVKKISLQLMNLFNNFTEDNVQLNKHFSIMSSIQFLEVCRDFRLGDMLRLRMVKSRMRDGSGLSCTEFLYQIFQSYDWYRLSHDYNCYFQIGGNDQLGHFDAGYDYIKKKTGKLSASICLPLLTDAQGKKLSKTSKEGSNIWLDERKTSPFTFYQYFRQKPDSAIVPLLRYFSLRTIEEIEEIEREHQANLGKWVAQEKLAEELTKSVYGSNGLEMAKKCSELLFRGSLSELRKMPVSFIEEQFGSASVQQLFRSSFSTMGELAERVHDGEGCSINKMKAGALKLNGIRYMDPDEVVDFDKICLDGKNITLVCWGKRKYHLIRWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYK2</accession>
    <name>A0A183GYK2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal-dependent decarboxylase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS312</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000091">
        <property type="protein sequence ID" value="VDO25343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYK2"/>
    <dbReference type="STRING" id="387005.A0A183GYK2"/>
    <dbReference type="WBParaSite" id="OFLC_0000031101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000031101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000031101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055103">
        <property type="entry name" value="PDXDC1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055102">
        <property type="entry name" value="PDXDC1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF1">
        <property type="entry name" value="PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22930">
        <property type="entry name" value="PDXDC1-like_cen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22937">
        <property type="entry name" value="PDXDC1-like_cen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDXDC1/PDXD2 second" evidence="8">
        <location>
            <begin position="472"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PDXDC1-like third" evidence="9">
        <location>
            <begin position="591"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO25343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000031101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="837" mass="93944" checksum="CE75C0F28ED6E723" modified="2016-09-07" version="1">MCSNLRYGYSLTTEMHNNGSLNDSDVIERSILERLVYATDGNSSNSVEKLQRNTRQVSSTGDDNISQILQQLERLILSDDWIDKEIKDCGESSQSSYPEFPKKRGHIVSSRLSELGRTLVISSSLRSYINLLGTHHRQCIASWLYGSTSQTLSTLFHTPNNNLHCSEHDSTFANSIKAGIGYAIRLALHDTYGSDYSSKGWRVFLEMGSPVVYISPALHIDLTSYLSTEFLIGDIVILKKSDGAFANIEGRIDHIAFEQQLDDDIAAGKKPLIVIGVVGSAILGQNDIISRLLEIRKSKAQFWIHVVGQGLATLCLKEPSETHVKVLSQVDSFTAPLALWLGIPAAPVITLHRSIDNQKLVYHEKLIVLPWWIACHHLTSSRITDTIENAYFLSKVMLRGLIAFPQIEIFGVENPIEFANRVYEGIYTSPTVLIFNYRYPDLGEIKKEKILTADSPSFSDNLTNDYMYSDDANEMFVNNSFATSDNDVDNPAEYADSLNFWLNQRLISDCHQLGLQMITLGNTHCSAFRFCPLESAAFLISLLTSHFCSHSLRIRIFSLNCTNVDHVHKFIKQLSDALKIIESTVAAKKRFEKIISEYPSLGLTPVRKWAGVGAVCYIPSIVKETPMNEWNEKQRQQVSHLNLELVHSLHSVDMTFSIGESPACGVSCVKFGMLSDDKDLRDLVHLVVEYGKEVEQSQKYMDSLAEMIRQGIEAANKDLKRENDARIMQEGVIRQIPLMSSLVNWFSPLDKDLQNIKGRSFDLKTGQIQSTDVYYKHGFINQMDAISQDPHQMIAKISNELVKKQSNINSNRDTIENNNITVGNANENGEDCSSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYM0</accession>
    <name>A0A183GYM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bm4292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS330</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000101">
        <property type="protein sequence ID" value="VDO25425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYM0"/>
    <dbReference type="STRING" id="387005.A0A183GYM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000032901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000032901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000032901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO25425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000032901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29542" checksum="B5333BB9E297225A" modified="2016-09-07" version="1">MNRNTELNARLKDNVVRNPLYFSRSYGLFLVCFSDAVPSDIGSFSKFGSPCIWNDDYYPLDAAYEKYDSLQLYRYYAMWGAAILYLLGLVVFIICSIFGMVGCWRRSTKIVLTTALLMLFSVMFLAGSMACWHLVNYLERHVLDIPPFYKSWEPILKQGTRFSYGWSYVVSWVGIAFILLASTFMLLSYKKIKEEEERAFEAKHGAYMMPNYYDKSSAMMPYGYGTYGGYPTAYPAAYYGQYPVGTGYYGYMTYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZV7</accession>
    <name>A0A183GZV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS767</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000293">
        <property type="protein sequence ID" value="VDO26990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZV7"/>
    <dbReference type="STRING" id="387005.A0A183GZV7"/>
    <dbReference type="WBParaSite" id="OFLC_0000076601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000076601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000076601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO26990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000076601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53213" checksum="9189C77A1645EF62" modified="2016-09-07" version="1">MHGSILKDPVAVYLLKFSPLTRLTIVIFGAVLIHLSLGTYHTFGNMLPYLASYMRNNTDSTINHEMLVWIPTFQGCFPFAMIIGGFVNAKFGLRLATSLGCTIMTAGVFLSYWTIRRSFQAFLVTYGIMFGLGQGMAYVLTVSCWAPKHVGFVSGIVAAGFGISSSIFAPLQTIYLNPLNHKPTVFAYFTDRDMIARVPSIFYTFAAVYGIMQIIGLIVICDPADVDEQSEALQVQISISLWKWIDEVFKSKRTSLCRDTKQYAYSRLRTFSQRSMSESLEEEMVNLSEEPLSLSPLQMLRSSTFYWLFCTLFCCSFYGNMFYNLYKAFGETFIDDDMFMAYAFSTASICNALARIGWGILADRTSFQVSLACATFLATILLLTMPFTPFGGKWIYFIWMNLMFICLAATHALFITASVKCFGLDHKSTNYGCLIFSTTLSAILLAIGCEYVLAIVGYTFAFLITAILAFIGKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZX1</accession>
    <name>A0A183GZX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS781</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000303">
        <property type="protein sequence ID" value="VDO27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZX1"/>
    <dbReference type="STRING" id="387005.A0A183GZX1"/>
    <dbReference type="WBParaSite" id="OFLC_0000078001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000078001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000078001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000078001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="599" mass="66789" checksum="A3C5848D880EA0BC" modified="2016-09-07" version="1">MGSSSSRDSPRVIVRCSSPAYCVQVVGSRHILLGGGGGASKTGVPNNIQTLLLSFDSKSLGIATENLSIANEQLPLITEITNSLETDPYATMNMDCVLLGASEQGKYLLAAGHDEYCDLYESKGFTLSKLKENEEPRLALSFEKLSRITSDEKPNNAYQKTVRFDRNVEGQSQRLYTGGADGCIRIWDVETIRQSSTSKHTPLIKIKAHQDDVDDLDISPNGKLCISVGHDATVYIWNTENGEKICSLPVPKEVGDGFRVRSVRFTVLGSKNTIFLATYNQIRLTKKAVSHVALWAFNHERNVCRPILVREACKETISALAVSDCGNFFALGTMDGGVGIYDTHELKPLYFVQKTHGIFVTAVQFLSQRTYDFGPLNGGNGRQRSLYPGVASEYRAAVISLSADQTVQFHAVPFSKPTSFTYFLCKLSLLAFFLYYINMYAGKIISAKGYETPRRALGDLKNVFATPVSSAIKRRIPEKSQSLFDVYHEKETNKNERNIVSAPEGEDFEPVQENDDIIEKFNFEEHAETYEEIFPRPDQRIDVADLLHSVQTDNRFLRSLFSELLDEDSLRLLNEKNPLTNEDCDKALTEILGGEISKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0W3</accession>
    <name>A0A183H0W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1123</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000486">
        <property type="protein sequence ID" value="VDO28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0W3"/>
    <dbReference type="STRING" id="387005.A0A183H0W3"/>
    <dbReference type="WBParaSite" id="OFLC_0000112201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000112201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000112201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="155"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000112201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113878" checksum="46381DDBA00DB26D" modified="2016-09-07" version="1">MDLCNEYSGLDTLTMLCDRLRSEKLLIASELDTLQRLNEEVDNAQSELAHLAWICRQEQTILSRLINSHPDVRPENCCFLTSQFDSARFIDGYRRIDGQHYSSVTELLNLLLNSPNLVAEILHTADQTLKNNNSPFAELVSCVYSLLYGCAVFPEDERRVLETLFHLLDIQIASHSDPRLLLRRGNVSFCQLYRLFSEGMYSAKIFLTAALHDPVMFVLSQDDVFLDIEPTKTLIRFPVEERRRRFGEDENSLTFLQKLTTHRRYVESKLISVANRFIRAITDVMSCFPQSLSCIVRRLYTVLVDQRKLSREQATLICTDLIFTYLICPAIANPETLGIISDTPVTYIARFNLMQIGQILQTLAIAPFEPPSTHIAHFYSQFDQQSMSSVMQHILTTHGDSIENICAISTESPPQVVEQFVRRMFVGTVAELDSLISAVRCLAINSLSDESLRRVLTGILRRLPVRLARSDISNFGITEKRMTFSVESSDQKGSRTKHSKSMEPVESNHIQARNIEVLIFPLGEEREPLGMCSEEKFMESVQNPQRVRKHKTSDESAEKRTRFVDTESIDHTTDGGSDDEEAASLSSSIEGNADGMDDDAEDISTLPDNFSDVVPSSTNVSGRGSPSVSDPASNQGGSRSFRSAAPSNSENVNNARQENSNACQHNLPNLPVTVRRENTEGLEDKFGKFCLPPQGESRHKYRDETHSLISESWSTDVLPSDTEGFGFDTRQEGDNSTSTVAPPVLPAVVEVGEPRNESRPNRTGSQRSTIGSTIACLAVVGNGEDRSDTWSVDAVASDSEADPVQRNDDLLMIDDPDGADNASATSGSANATMLASACSGSSMIAGGSAASQVTFGEHNQNEASRGNSFSFQHVTKKSVPTPSADASIFRELNQGNLVASASSGHGRERLRRQSSGSSFYSKSDVDSEFSKDLNDDALSSLPGDYTPSFRNSVGELAPTSPAASVMATAGSFCNDDVEAGSNVVPTNDDLINSSRNDVTVTNIRKTEKCPEYEERIMVSIYILSKLGHSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H178</accession>
    <name>A0A183H178_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000552">
        <property type="protein sequence ID" value="VDO28789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H178"/>
    <dbReference type="WBParaSite" id="OFLC_0000123701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000123701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000123701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO28789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000123701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13483" checksum="0A1C892EA0C99202" modified="2016-09-07" version="1">RKGPLPDFQDIIPKEDWDKLTAVYQDTNLDNIEKLRRVDEIIDALPDSIRQKIPLSPPFQKLPDHIQQQLQIIHTQRGLTTEQRFRKMKAIVESLPWDMKELINKVHNVIPRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H217</accession>
    <name>A0A183H217_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1527</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000733">
        <property type="protein sequence ID" value="VDO29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H217"/>
    <dbReference type="STRING" id="387005.A0A183H217"/>
    <dbReference type="WBParaSite" id="OFLC_0000152601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000152601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000152601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000152601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17706" checksum="66F252B22B6FD96C" modified="2016-09-07" version="1">MFDPLERVITGVRLGGVGPLIATSPTPHSDPNLVGIQPIDIHQFSQNPNIWSGMEAMNAQGSMTQPQHASLQPTLQQSSPYAQILFVKYVKVFVIHSQVPNNENSGVLFEETTMVVDSQVPFEIRKLHEHHPGISILTTDYSLNLKILACCSQLGQPEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3I8</accession>
    <name>A0A183H3I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2048</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001102">
        <property type="protein sequence ID" value="VDO31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3I8"/>
    <dbReference type="STRING" id="387005.A0A183H3I8"/>
    <dbReference type="WBParaSite" id="OFLC_0000204701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000204701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000204701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09340">
        <property type="entry name" value="LIM1_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09827">
        <property type="entry name" value="PET_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033723">
        <property type="entry name" value="PET_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="8">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO31698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000204701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54753" checksum="1002FA6B15AB455B" modified="2016-09-07" version="1">MDTIISRCQMSRGCLSPASRIRIAADVHRHSISDDDSGCVLEEYSWVPNGIKPDMVHMYFACLPEDKIPYVNSTGEEWRTRQLYYQLPPQDSDARYCDKLNNKEIRELVQFEVGRKRECLGRGIIEQLPYDNKRRLCHQCKGLLYEGNLVIIAERFGRDVHWHPQCFVCTECSNLLVDLIYFKHRSDVYCGRHHAEQIKPRCAKCDEASSISASDFCSALIFSEECTEAEGRTWHMAHFSCSDCGIQLGGQRYIGRNDRIVCISCHNQNSSLVCNTCGKEIVVDKPHIIQNDIHWHADERCFCCTECSKNLLGKKYLFRGGKLYCGMDTKCGKRCPKVIFCTKVKSISSRRRGSIPEPPSRDPPSPPAENIYETVLPCSSRESDGRNGAKHLRGCNRRSQSVDVRRSWCNEYCSKEYCKKKRDHEDKKQNHYSQMPPSSPLLRRRHQRCSSCSSSESDSDDVYLLNYLAASLSQFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3M4</accession>
    <name>A0A183H3M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2084</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001129">
        <property type="protein sequence ID" value="VDO31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3M4"/>
    <dbReference type="STRING" id="387005.A0A183H3M4"/>
    <dbReference type="WBParaSite" id="OFLC_0000208301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000208301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000208301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000208301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5487" checksum="3FF6B2C6D3B010C4" modified="2016-09-07" version="1">MSRNNEEEEEEEEEEEEEDEVPITLRKGSGFKMVTSVTPVVNQDKTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3Q7</accession>
    <name>A0A183H3Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001154">
        <property type="protein sequence ID" value="VDO31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3Q7"/>
    <dbReference type="WBParaSite" id="OFLC_0000211601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000211601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000211601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000211601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8317" checksum="7484CD2D9BFFC3BA" modified="2016-09-07" version="1">MLIDFVRDPLRFTYACELHVQAEHNVEILYSVCIDPKNRIVTLNSLHRDGKLKFPCVIICYHITIIMPQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H417</accession>
    <name>A0A183H417_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS2227</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001236">
        <property type="protein sequence ID" value="VDO32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H417"/>
    <dbReference type="STRING" id="387005.A0A183H417"/>
    <dbReference type="WBParaSite" id="OFLC_0000222601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000222601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000222601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061177">
        <property type="term" value="C:type Is terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900073">
        <property type="term" value="P:regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000222601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14717" checksum="A0473352F5F561C6" modified="2016-09-07" version="1">MVLSSDLGESGSQEDGRSNSKQRKTKGPSLYEILGITKDASDDDIKRAYRKLALKYHPDKNLDDDPEKTERFKEVNHAHAVLSIPTRRKMYDEYGDMGLKLMEQFGDDSAAINLAFKPWFKVRLIPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4H1</accession>
    <name>A0A183H4H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2381</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001359">
        <property type="protein sequence ID" value="VDO32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4H1"/>
    <dbReference type="STRING" id="387005.A0A183H4H1"/>
    <dbReference type="WBParaSite" id="OFLC_0000238001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000238001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000238001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552375" evidence="2">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000238001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19811" checksum="A48B1742BB92E96B" modified="2016-09-07" version="1">MIFTIISLLIRIALCKGDYCGENKIPFGIEVYPNAQPLLHCSRPSCFERRYADCDDRARRKSCESNDSWVGGFEKSHGNHEPLYVLCCEFEGLADHSSPLYQTIIKPGQYFEGEEQAEEETDTVVSFDVITNFKMIRSPNLSIFYEMTVRRLRCYELPPVDRIKRVRRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4P6</accession>
    <name>A0A183H4P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2456</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001415">
        <property type="protein sequence ID" value="VDO33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4P6"/>
    <dbReference type="STRING" id="387005.A0A183H4P6"/>
    <dbReference type="WBParaSite" id="OFLC_0000245501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000245501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000245501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000245501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17826" checksum="7887B4A5B9F8879F" modified="2016-09-07" version="1">MFDLHIPELLTELGLFAIWVTNNIRHFKFIDDMIEYFGFEKIATWRWLKVTNDGEPVYSLNSQHKQPFESIVFASSSASHHMNIVDEFVLIRHIFHTPSAIHSRKPPLLPVLQALGILEELAVQLELYGRYLLPRTTTIGFEAAKLQNKRYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6G8</accession>
    <name>A0A183H6G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3079</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001948">
        <property type="protein sequence ID" value="VDO35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6G8"/>
    <dbReference type="STRING" id="387005.A0A183H6G8"/>
    <dbReference type="WBParaSite" id="OFLC_0000307801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000307801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000307801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552398" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000307801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12878" checksum="904FB660DEC98815" modified="2016-09-07" version="1">MQLILIFYQLIVVTTAIKVIDNGLAPPEIVHSPILTKPRCIVKAEPLDLVFLLDSSGSLKNKFQDEINIIRRIVNHVTIGEFATRVMLIQFRCFRYSKYSYLKNSLIFYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6I0</accession>
    <name>A0A183H6I0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3092</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01001959">
        <property type="protein sequence ID" value="VDO35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6I0"/>
    <dbReference type="STRING" id="387005.A0A183H6I0"/>
    <dbReference type="WBParaSite" id="OFLC_0000309101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000309101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000309101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="2">
        <location>
            <begin position="455"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000309101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="730" mass="83133" checksum="A939C959E6BDF2C6" modified="2016-09-07" version="1">MVKDVGLACRFIISKMPLDAPVAQRAIPLAIFQATPNISAHYLRKWTKDTTITKDNINIRNIIDWEYYIERFGATIQKIISIPAALQNIPNPVPRVPFPDWLENKRQQRKNDHKQPKINEIFKKTATSAFAPDIENVTNLKVANGSLSDDVTLNNNNFPNLEKDSSTLKATICNFLNATTKQSQSSTPTQKTDQWTVIQKKTIVEHGVDEWLRYLKAKWLKERKEKNHRKQNALSKGITPIMSMLERGKQIMRDTVWQIVKVKCYYCKLKLMWLQISETPNKGMLVLWCIILDKMMKINVRMRRIIYVNNREENGNFGTIVKRILPRLKPVFNLQRYVIDERIFESSLNQLNKELCAMRIEGVYESQVPLLFRALLTIGCSCRLKPDLQINSANTYDFEQLESDFSVHYLPENSIRTLFFYEHHQDSRCVMAVFNTAKSEAHIVVVNKTELNLPNLSNMYASEKANLSADVNVSFLNRKVDMNFTVNQCVAIERADRIIQKYIRSLHQADSYPTMIAVQSRQHLSALIKRLPALDSYPLVQIHASEPSGLFNVLDWQRIVLRRIIKHYFNMFLYLNQYVEVSRYLHVPIGNVPEDFSTFGPDVLFARSLINQGYVLWASPLSRPDLGGKELDDARLNAVWSSLCVKKQPTCVINESSFETDVCVELELGAVDVTAIVQSASIADAEGGADSVGFLTGAVLSADALLGHVRSIAQYDEGAAVAGPLKVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H794</accession>
    <name>A0A183H794_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3353</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002216">
        <property type="protein sequence ID" value="VDO36211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H794"/>
    <dbReference type="STRING" id="387005.A0A183H794"/>
    <dbReference type="WBParaSite" id="OFLC_0000335501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000335501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000335501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000335501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14900" checksum="8AEA86854CDF956C" modified="2016-09-07" version="1">MTKDEFLKMKQELEQEYLATFKKTVAMHEVFLCRLAAHPVFRNDPNFRIFLEYEQDLSVRAKNTKELVGSFWKRLTQSADEVLLSGQKDVDDFFEHERNYLLEYYTHVKEASLRCDRISRLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7A4</accession>
    <name>A0A183H7A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S1 motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3366</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002226">
        <property type="protein sequence ID" value="VDO36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7A4"/>
    <dbReference type="WBParaSite" id="OFLC_0000336501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000336501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000336501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000336501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28613" checksum="9AEFC60C4FFE2A3C" modified="2016-09-07" version="1">MNNGFITSKTQKGVITRTLGNLISVWPLNVHQEKELVFQDRAPISSQYLKVGDWIQMEVERGDEVVYREKIEPVLQTLVTLRGNIQVKTRIYFPNGINSEHVIGYSDDLGKVGIFFHCPELKANSLYDVWVSRPRKKFASLAKRYNVHWYLIRQPVVPLIRDGNARFFRKIWSNDDNSEHFNSTLTENNVNSCEINFSYVSFCALNFNDYALRKLYSDPKVREAVYQCNSDFARSIETYLRKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H803</accession>
    <name>A0A183H803_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Orexin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002480">
        <property type="protein sequence ID" value="VDO37155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H803"/>
    <dbReference type="STRING" id="387005.A0A183H803"/>
    <dbReference type="WBParaSite" id="OFLC_0000361401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000361401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000361401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000361401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19530" checksum="CB6C42114E9129C2" modified="2016-09-07" version="1">MFIGVSDWLLYIVVTQIPIIRSGCYQKQLCCLGGNFTCIAVDDGIGHLPTKLRQQRLKKGRRGRWHTVDRKMKRIGKLVKQDFLADNGLEVASNHGYDSSGDYLNNQGEQTDSIKLSNNIEISPFVRYQLIFGQPSYSEEQQPETIRYYKRHKLIRYLSSAVNVQRKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8J0</accession>
    <name>A0A183H8J0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCD1 alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3801</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002661">
        <property type="protein sequence ID" value="VDO37785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8J0"/>
    <dbReference type="STRING" id="387005.A0A183H8J0"/>
    <dbReference type="WBParaSite" id="OFLC_0000380101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000380101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000380101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO37785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000380101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25320" checksum="AB66DDF40F5EDC8E" modified="2016-09-07" version="1">MNFISKEISLFSLFLLNKMMSNSVFFSFYVIDLSKTILDNTRNRFILEHPTFIVTLDNQFNDYVMLSEQEARELRELQRQKSRDENQNIKQNNFRGRGRFDSGRFMSRGRRGGRGGFKRTYNSPDGKTSRESGRPWKCSRLSRGGYYQRCDFYERNNDSRDMPDTPNFAVQDCDQRPSISSQAEDPIIDAWSKALEIKSKKEVLPNADSSNEVQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H918</accession>
    <name>A0A183H918_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS3979</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01002851">
        <property type="protein sequence ID" value="VDO38461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H918"/>
    <dbReference type="STRING" id="387005.A0A183H918"/>
    <dbReference type="WBParaSite" id="OFLC_0000397901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000397901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000397901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="312"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO38461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000397901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42350" checksum="52549244B57340E7" modified="2016-09-07" version="1">MLCHTVFSLSDVYDKVLAFNNFSAAQVVLLIPAALIILNSFFLLDITLLYAGISFMLTIALMKLVLLRYSLIALMYLVMNAPDIAVTETSVAAGFSTVFTHDASIHLHVAPYCAGNTEKIAGVPNIVTVILASFRGYDTCCACGRDAACFISFALFTSLCSGFLIINSNIEVGYNPKLGTLGAGNHYGEVQVVEEIYDEYAASRMGIDRLGQVCVMIHCGSRGLGHQVATDSLVAMEKAMKRDNIIVNDRQLACARINSMEGQDYLKGMAAAANFAWVNRSCMTFCARQAFAEVFNTSPDDLDMHVIYDVSHNIAKIEEHLLDGKPKQLCVHRKGSTRAFPPHHPLIPVDYQLTGLFSSFYFGDFILKITKSVQQYRVNNLFEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9X0</accession>
    <name>A0A183H9X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4282</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003184">
        <property type="protein sequence ID" value="VDO39511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9X0"/>
    <dbReference type="STRING" id="387005.A0A183H9X0"/>
    <dbReference type="WBParaSite" id="OFLC_0000428101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000428101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000428101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO39511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000428101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35633" checksum="517722DF6AD88D30" modified="2016-09-07" version="1">MIYEASLKKSHSHHSVDSYNEETGPGLFPNKAKLPSGIENIRPHLENVDNVPLLVNLFTDCDHFSCQKMIEIMQIIIIQDYGEVVLVVGSSLNYFNSNIFSQGNCSISIEPQHPALCSRKISQNDSELKKASTIATLLMGLCCDIVVFPSQTMDLISLITFCRHQLGTFRSSFLFFLYSSTALTLQQIFTLLFLPNVLSVFQVFLFIVVYIPLLASSLMASSHKFDENRDEIAPKNVSSAPKRTVHRAIIYFSINFLPTLIVVCLIYYSTLLLYLCTLSMGFVHFRDNCWAKYPSSNYYWIATICCIILIQVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAC8</accession>
    <name>A0A183HAC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003378">
        <property type="protein sequence ID" value="VDO40025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAC8"/>
    <dbReference type="STRING" id="387005.A0A183HAC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000443901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000443901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000443901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000443901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29840" checksum="B2F649CAFD41D953" modified="2016-09-07" version="1">MQSREDCLSDWDTKTTDQFDVNNIMIDYLIKDRRNSEKEAKELIARKWGKNRRAIKNFACRYTVKSKYFLTKIKKENHCFQIVSFGAETVITQIVPTFKVKRQIYHKIVSLLPLLDGQRKSLQLCFINDNSDEFNDMKSATASRKKQFNTKWQLLESAINSNQEILFFISETEIADISIQHSSGNSGYPLYRRSAEDNARKYLSSNEDDGEFFHFSYMNEVRVVAHLAVHLENVQRVYFTAANVQQIALNPRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAG1</accession>
    <name>A0A183HAG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4474</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003409">
        <property type="protein sequence ID" value="VDO40104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAG1"/>
    <dbReference type="STRING" id="387005.A0A183HAG1"/>
    <dbReference type="WBParaSite" id="OFLC_0000447201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000447201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000447201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="81"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000447201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24732" checksum="738B480E06282219" modified="2016-09-07" version="1">MAFWIFSWNAWIAWVTSIIVTLAIDWDAEIIASPEESQFSYQGPLWTYFGNKSENVSIFHSREYMQKRVGKFKDVDPERISNHNYSFMTSWLKEYSIKYPNITWLYSIGESVRNRTLWVIAISRSPRFRELGIPEIKYVANMHGNEVVGRELMLYLIALLCDNYGKNKYLTNFVNNVRIHIMPSMNPDGYESGIEGDRSGFVVSLCLIITQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAS7</accession>
    <name>A0A183HAS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4589</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003553">
        <property type="protein sequence ID" value="VDO40424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAS7"/>
    <dbReference type="STRING" id="387005.A0A183HAS7"/>
    <dbReference type="WBParaSite" id="OFLC_0000458801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000458801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000458801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000458801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10412" checksum="346B742BDF44C5D8" modified="2016-09-07" version="1">MVPSHVNLTYSELHGTIELCIERALIHNYADLELCAALVFSAPVTDIKKVLLKTRSWCVIRKSPHITLNLIRLARFCAVVLDDHSSDKQLSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAX3</accession>
    <name>A0A183HAX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4634</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003617">
        <property type="protein sequence ID" value="VDO40574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAX3"/>
    <dbReference type="STRING" id="387005.A0A183HAX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000463401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000463401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000463401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000463401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30577" checksum="98CF7057B14E781F" modified="2016-09-07" version="1">MLKSNFLGRFQIVRHGFPDDPRCMAYDTVQRLLAIGTGHGIIRVIGDVGVDYCLKHESDSAVLHIQFLMNEGALVTACYDDLIHLWNFRQKVPVILHSIQLTKEQVTCISHSFQSKWLYLGTERGNVYFVNIATFTLSSYVINWNKAIDLSVRTHPGSVKAISACPTELSKLLLLYEKGTVVLWNLQTKEADRFISDHSTRCIAWHHDGRQFMCGTADGSLLIWNVRKPGECIQKLQPHGQNCSPITQIDWKHSADGEQLIIFSGGQYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC55</accession>
    <name>A0A183HC55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS5066</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004166">
        <property type="protein sequence ID" value="VDO41941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC55"/>
    <dbReference type="STRING" id="387005.A0A183HC55"/>
    <dbReference type="WBParaSite" id="OFLC_0000506601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000506601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000506601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO41941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000506601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23266" checksum="B6FDD41A6FCDF92D" modified="2016-09-07" version="1">MSLLHASLESNEWRSNRVLRSHRLLKCLAQCHVVLGLIIFILAALADYMSSRIHTIRMVGLEECCSFYFILTGIIGICGSASHRRGLILAFMLMNLHAILIFVPAIIIVSSFDIHFYQAECFGECDWHLLTPSLPENSRCQILCGENIDDNKRSLMTRLGTEYRLDAGIIAATILQMVLSLFSASLCCREVCMECRPIMWNDAVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD88</accession>
    <name>A0A183HD88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nsp1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004691">
        <property type="protein sequence ID" value="VDO43200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD88"/>
    <dbReference type="STRING" id="387005.A0A183HD88"/>
    <dbReference type="WBParaSite" id="OFLC_0000544901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000544901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000544901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000544901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21313" checksum="F47E08C41C839E14" modified="2016-09-07" version="1">EKKFNFQTGTAALTKKKKLLEQPLESLSDIKIWVDSIAEVDSQLEVVCSAANSTSILVSDDFKNEKERLEKEWHQKTETISQLQTIHDTIGILQNRLAENQSLSELVFLDAEIDSLNRQCMNIVDPSVISLRNCYRKKIEEELCTIVTESLSRAERQITELSMADETDVRRAVDILQSMMPAFASSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDH6</accession>
    <name>A0A183HDH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5538</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004812">
        <property type="protein sequence ID" value="VDO43472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDH6"/>
    <dbReference type="WBParaSite" id="OFLC_0000553701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000553701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000553701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000553701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31384" checksum="A25BAC07A39DD8C1" modified="2016-09-07" version="1">MRNRANHLLAALAITDMAVFIFMLPTSLSAMQRFYESTTFRIIYAHTKTHFAALANWFSSAAIWIVLAVSAERLLIIKFPFRSLKQYHALGSVITIFVILAFTLMLTCFHHFSYRCATLWVCNMTQVYVKCLPVTWNWTEFGLVPHYQPSERFAFYINMSVIANAFIGVIIPVFVVAFLNVYLIRLLQIRTEQAKSDEAFLGSASGNFCEQERKMTVTIAAIVTCFTVTQLPSAILFLYERIINDAKTIAFSKASCITNSLVLTGKMLNVVLFCLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDH8</accession>
    <name>A0A183HDH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004817">
        <property type="protein sequence ID" value="VDO43478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDH8"/>
    <dbReference type="STRING" id="387005.A0A183HDH8"/>
    <dbReference type="WBParaSite" id="OFLC_0000553901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000553901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000553901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000553901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45331" checksum="52C10E07559C0B92" modified="2016-09-07" version="1">MVDPVIKNVQFEQLESYFKQIHETYPNERAFVLYIDSRDNTHEVISDDLKLYEVLHRIITQHIHGSRAREAPKKVATLENIINKLNCKNFGQCYGVVPESFATNKWISTGKTLIIGYDVCHPEPQPKHERRMRMSPTQPSVLGISFNGAVCPETFIGDYSFQEPRKEQVTSSILEERIYWILSLFCGSRNGILPETVIITRDGVSEGQFRMVMEDEIEAIRQGMRNFGKAKAGIDNYSPNIVCIIACKRHNKRFAIENGRSLENCLPLTVIDRDVTRPDTTEFFMQSHKIIKGTGKLPAYSMPINEANLTMDEAQSLMMALCFTHQIVNQAVSIPEPIYQADEWAKRGRNNFKAMLRRVGGKEHLPILDGGNVDWNRVTRRLCYMDTELELTRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDM2</accession>
    <name>A0A183HDM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiolase_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5583</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004871">
        <property type="protein sequence ID" value="VDO43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDM2"/>
    <dbReference type="STRING" id="387005.A0A183HDM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000558301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000558301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000558301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF133">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000558301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39142" checksum="79416DE35BF6685D" modified="2016-09-07" version="1">MVENTSSKNGAVYQLEDVYIISAVRTPIGGYRKMLKSCSPVYLGTIATKEAIRRAGISPSNIDETMVGCVLTSCHGQNIARQISINAGIPVTSPSVTINKVCSSSMKAIIMAIQAVHLGDRDVVLAAGTESMSNAYYGVPRGDNNDMNSPFVDSMFEDGLSDAFTKLKMGVCAEKTCSEYSISRKEQDEYALESYRRAHDAWKEGLFTEEVIPVKCFDSNELFQDEEYKKLDPLKVPILKPAFIPDTGTITAANASSISDGAAALLIASGSFINRQSCQPIALVLGYAEAALEPVEFSRAPSVAVKKLLSKIGLSVEEISLWEVNEAFAATAIVFLRDMGLDSSRVNVRGGAVALGHPIGFVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDQ5</accession>
    <name>A0A183HDQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5618</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004924">
        <property type="protein sequence ID" value="VDO43747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDQ5"/>
    <dbReference type="STRING" id="387005.A0A183HDQ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000561601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000561601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000561601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO43747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000561601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10559" checksum="A37C0A1CEE0631C8" modified="2016-09-07" version="1">MSEDVDTHIIERYDLHKRLGKGAYGIVWKAIDRRARETVALKKIFDAFRNQTDAQRTFREIMFLQEFGRHPNIIKLFDVLKADNNRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDW9</accession>
    <name>A0A183HDW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005014">
        <property type="protein sequence ID" value="VDO43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDW9"/>
    <dbReference type="STRING" id="387005.A0A183HDW9"/>
    <dbReference type="WBParaSite" id="OFLC_0000568001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000568001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000568001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000568001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="18702" checksum="F702F84097A063D3" modified="2016-09-07" version="1">MLIRQPGKGNLAGTGTAIAPSTAMYSDSSGSYSYPLDNTQMMITPGNHETAIQDMSSSAVAATAYWNTSNLPQHNPYTQLISGSYNGTMLPMHSATDEDYARSLSVTASVAYPVPVSASTTPANGDVVEIGKLYDNDSNNPGVTVPPPMYSAHHSTTCYPQYFPSYVPPVSFRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE35</accession>
    <name>A0A183HE35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005107">
        <property type="protein sequence ID" value="VDO44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE35"/>
    <dbReference type="STRING" id="387005.A0A183HE35"/>
    <dbReference type="WBParaSite" id="OFLC_0000574601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000574601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000574601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000574601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30039" checksum="F4C9A164B1284305" modified="2016-09-07" version="1">MNKSFQEFIYEFFPQESEWQLLKNPITLSQFETLPFVRSLFFRYGLSFTDPNLHAIVKADRNGAATISITMSNEALNSLIFHYNLRFFDNDDAEMNGYNLKRFVMQSVIGDSAIFRVHCPSTRSLLLDIFANAVSPGHYLTGQPIKFKSICKFKIICEKLNVIMVPLPECASGEWGPAKAYRLFGLIPLTHEDAIINCGRTLKINFRMMKPLAEFVASLHMNQIDDRNLQNHCQTLIHGDTVRIQIDFYEDGQYGLDIYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE60</accession>
    <name>A0A183HE60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5771</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005139">
        <property type="protein sequence ID" value="VDO44265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE60"/>
    <dbReference type="STRING" id="387005.A0A183HE60"/>
    <dbReference type="WBParaSite" id="OFLC_0000577101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000577101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000577101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO44265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000577101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32175" checksum="112D4B12B4453FD9" modified="2016-09-07" version="1">MAPTSKLNRKLKIEGTDLPTAIHVSNSASCSLEDHENAFVFQLNGQPKQSCIDNEIWPPVFKPEFVRSAKAMIPRDTDIFVCTYPKCGTTWIQHICSQLLTDNYGPQVGRELCITSPMIERMGAKFADNLDSPRLLKTHFTWHNVPKNSNAKYILAVRNPKDCLTSYFYHNRNFKIYNYEHGDFSAFLELFLTKNIAFGNYFDYLLSWLPHINDENVLFLKYEYMCADLPQAVLKIGEFLGGKAAKNVRDEAILSQIVKNSTIKSMKQDQWRWFPENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HG60</accession>
    <name>A0A183HG60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6472</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006165">
        <property type="protein sequence ID" value="VDO46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HG60"/>
    <dbReference type="WBParaSite" id="OFLC_0000647101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000647101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000647101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000647101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11393" checksum="FAFD4DD3C25CB658" modified="2016-09-07" version="1">MDEYMCVSNTINLLLIYSFWLFPKLRESQWYRLEVTKSHMNHHCYQLSLIIMALHFVKEGGGEGEGESARFALIDYISTCNLDLDLKLFYGIYMPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHE0</accession>
    <name>A0A183HHE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6902</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006861">
        <property type="protein sequence ID" value="VDO48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHE0"/>
    <dbReference type="WBParaSite" id="OFLC_0000690101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000690101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000690101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000690101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="34" mass="4301" checksum="E3FC36157A24D85A" modified="2016-09-07" version="1">MVLENNRNWNRCMNSLHHILSSLFWFLLKYYKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIB8</accession>
    <name>A0A183HIB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007407">
        <property type="protein sequence ID" value="VDO49918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIB8"/>
    <dbReference type="WBParaSite" id="OFLC_0000722901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000722901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000722901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000722901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23660" checksum="0BDFC48A18E2A5C5" modified="2016-09-07" version="1">MSKVKILTVGQNFQPEKSKSGILLDRCDRWTAKILEDFPVIQMNDDTFPRTVFPTLQSSVGGGKMVRVAPVKQWTTSHPYLSPALKSHDKYEVLETKRRLYDVVPKSVVLETTQKPSNFPTSPVYDRRISNYERILPKEDLENVHRLLQTPTPRRRYAPGIRVENSFSSPTADQFPPNSLPASILKTRKERQHENTSADSNIFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIP5</accession>
    <name>A0A183HIP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7354</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007629">
        <property type="protein sequence ID" value="VDO50597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIP5"/>
    <dbReference type="STRING" id="387005.A0A183HIP5"/>
    <dbReference type="WBParaSite" id="OFLC_0000735601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000735601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000735601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO50597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000735601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10858" checksum="5F0C0DD5C2B08332" modified="2016-09-07" version="1">MGHFYANYLADTFFNPTGWGKGQLFINGHNIGRYWPSIGPQITLYVPKPYLKHHNTIIMLELEKSGNCHNQFCTINFIDYPIFNFTESKNYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJM3</accession>
    <name>A0A183HJM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS7689</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008198">
        <property type="protein sequence ID" value="VDO52195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJM3"/>
    <dbReference type="STRING" id="387005.A0A183HJM3"/>
    <dbReference type="WBParaSite" id="OFLC_0000768401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000768401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000768401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000182">
        <property type="entry name" value="Paired like homeobox 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO52195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000768401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16947" checksum="5C35FBB786520145" modified="2016-09-07" version="1">MRANTAGLMAGIQGSSLVGGILIKGAICGKNNPMERRKQRRIRTTFTSAQLKELERAFLETHYPDIYTREDLAMRIDLTEARVQVWFQNRRAKFRKQEKMRRMKEEIRVQKNTQSGGHSLGQNNEDDEDRNCGHEVSSSNILLAGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK05</accession>
    <name>A0A183HK05_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MED19</name>
        <name evidence="7" type="ORF">OFLC_LOCUS7816</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008407">
        <property type="protein sequence ID" value="VDO52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK05"/>
    <dbReference type="STRING" id="387005.A0A183HK05"/>
    <dbReference type="WBParaSite" id="OFLC_0000781601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000781601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000781601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000781601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14120" checksum="F418A909596208E4" modified="2016-09-07" version="1">MLVEKPPITGKEITNLSASAMAGFRLTPGAVPEPYRYFDNKIEDVNGDATNYDENGEETKHKRKYKWSLDDLDDADSDRKYRKHRSEEKDRKKEKKKKKDKKRKKDLKEEEPNNKMRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKF2</accession>
    <name>A0A183HKF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7969</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008680">
        <property type="protein sequence ID" value="VDO53417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKF2"/>
    <dbReference type="STRING" id="387005.A0A183HKF2"/>
    <dbReference type="WBParaSite" id="OFLC_0000796301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000796301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000796301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000796301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17467" checksum="90B8E5F7802DFFEF" modified="2016-09-07" version="1">MNGSNWSDELLKDDTLHKEHEKSWPEKNSQSVCSPQCSGFTDAHITFRKKIPAVVPLMPSPVDSTPSLMLSPILLRPVRSLSTQNNFHGLSSEFDEEHRLSRQKAVASYQLPLTIATSKGPTVGAKTAIDRGSADNLESRFLVQMSHRRGRRLSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLR7</accession>
    <name>A0A183HLR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009523">
        <property type="protein sequence ID" value="VDO55603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLR7"/>
    <dbReference type="STRING" id="387005.A0A183HLR7"/>
    <dbReference type="WBParaSite" id="OFLC_0000842801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000842801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000842801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO55603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000842801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16187" checksum="BFEC4C3D0297C77F" modified="2016-09-07" version="1">MVAIPVYVRHNISFKPGTSGRIELTVGPKQSMGKVLEDVIVEMTMPKPVQNCMLISSTGKCCFDPTTKLLQWNIGKIELGKPPTLKGTISVSGTANVEAPPITVYFKINQLAVSGLKVNRLDLYGEKYKPFKGVKYITKAGRFQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLU9</accession>
    <name>A0A183HLU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009582">
        <property type="protein sequence ID" value="VDO55756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLU9"/>
    <dbReference type="WBParaSite" id="OFLC_0000846001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000846001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000846001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000846001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8476" checksum="514AA3E939E750F1" modified="2016-09-07" version="1">MTGNQVIVTDDNFSSIGKLTGSTNAAPNAKIMLLADQKYRKYARRVNQKDIEERKSGICIVYCLDLSQNPHKHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMP3</accession>
    <name>A0A183HMP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010153">
        <property type="protein sequence ID" value="VDO57230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMP3"/>
    <dbReference type="STRING" id="387005.A0A183HMP3"/>
    <dbReference type="WBParaSite" id="OFLC_0000875401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000875401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000875401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000875401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13291" checksum="FD98A520E4D8A415" modified="2016-09-07" version="1">MRGCVNRFLLFGLDEDVRDALTDKSECRTTDRRLLHLVALTPQTDLISLPASFPGGNVLMYGPAMQSRKHGLRPVDRCFFCMQRIPSDSYADFSLRSAHLDDISLVHVTCHALKAQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMV8</accession>
    <name>A0A183HMV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8818</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010286">
        <property type="protein sequence ID" value="VDO57550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMV8"/>
    <dbReference type="STRING" id="387005.A0A183HMV8"/>
    <dbReference type="WBParaSite" id="OFLC_0000881901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000881901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000881901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000881901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="15733" checksum="7B6CFACBBF672432" modified="2016-09-07" version="1">IPSAASANAGIGTPLLANFSNAQLATSLPSTATVTNALDLFGGSQNNAHLTLTPERQQMAAAAIAAAAAANALGGNFVAPRTPTHSSAAVSGTSAIGQLASTELLAQYALLAQQQLLHQQAAVAALSARYGSQVISSSSTSPHSTSSNSQLSSNPHSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNG9</accession>
    <name>A0A183HNG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010696">
        <property type="protein sequence ID" value="VDO58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNG9"/>
    <dbReference type="STRING" id="387005.A0A183HNG9"/>
    <dbReference type="WBParaSite" id="OFLC_0000903001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000903001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000903001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000903001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18895" checksum="4065C6068E44B3AD" modified="2016-09-07" version="1">MINLNQKSNQISIQFISAATGIILLYTRWMIRHCYLLMRGKNLEPFTLINRNKYHPPELVKFGLTDIPQYPGGNWRWKHKKWTFYASRGNRPYMEDRMHYLNDPHHNFVMFSIFDGHGGPVICILCNIMQVEYFLNLSKLFHLNIPKSPGNLDVCKILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNH7</accession>
    <name>A0A183HNH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gawky</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9041</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010715">
        <property type="protein sequence ID" value="VDO58479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNH7"/>
    <dbReference type="STRING" id="387005.A0A183HNH7"/>
    <dbReference type="WBParaSite" id="OFLC_0000903801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000903801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000903801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000903801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="21898" checksum="D5B4C787A978E3F9" modified="2016-09-07" version="1">MNIITPRVRVNDQRGGTGNQQRWLDHHQAQQWNTQGAQWGPHVAGGPSPPHPWPLTAAAQQWPGTPSPNTGTGGSTYAEHAKKNMFVRSGQGQVQGRYDQQQQQWNQVKVDQQTPWDTSSLAGFSSMHGTSDAKLSAAEWGSAGAPNTRWVPPATQWPVPAATSSATGPDWATAAAVVAAAAAAHHRHDATTAPWTNTTMAPHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNR1</accession>
    <name>A0A183HNR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9124</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010870">
        <property type="protein sequence ID" value="VDO58798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNR1"/>
    <dbReference type="STRING" id="387005.A0A183HNR1"/>
    <dbReference type="WBParaSite" id="OFLC_0000912201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000912201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000912201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000912201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6903" checksum="78DEE27181DBA226" modified="2016-09-07" version="1">MVHDYLLYENDLRKAARWFSTHANAILDAADSESSRETYRLLCMPLESFDGLTLPELALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNV3</accession>
    <name>A0A183HNV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9163</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010958">
        <property type="protein sequence ID" value="VDO58982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNV3"/>
    <dbReference type="STRING" id="387005.A0A183HNV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000916401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000916401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000916401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO58982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000916401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15583" checksum="DBEDABC8DF554779" modified="2016-09-07" version="1">MLRLLNRHIIRQGINAVTNGSRINSTRNYFLGPRYPLSSVFRSIDRQLQELERQFDRVFWNSPRDWFDSFRPIGIREHPSQTEAYRIQNPIVEEDGVKKFLLELDVRRFKPQEVTVKTNANENTLTIEAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNX3</accession>
    <name>A0A183HNX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9185</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011009">
        <property type="protein sequence ID" value="VDO59093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNX3"/>
    <dbReference type="STRING" id="387005.A0A183HNX3"/>
    <dbReference type="WBParaSite" id="OFLC_0000918401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000918401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000918401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO59093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000918401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23265" checksum="D169DD31E96A9F8C" modified="2016-09-07" version="1">TKCKYCSSESNPSITRHREAARAIRTIQKLPLTSADENYNNKFSNEDAVLEQIPLHKMQIDDANEIKSTRSNFSEISSAKSELSQFTSCTNPTFDSVHHIWRSGSLLQKEVLAVLAATTELIKDTNGTESDAEYFAALLTVIEVMPAVDESKLAAAAYLLGLVAKKIDRNVSRKCFSRAHQVDSFIWDKSKKLFLLTSVSVSLLLAIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPK5</accession>
    <name>A0A183HPK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9416</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011512">
        <property type="protein sequence ID" value="VDO60418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPK5"/>
    <dbReference type="WBParaSite" id="OFLC_0000941601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000941601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000941601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000941601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14923" checksum="F89EBC36925DC0A8" modified="2016-09-07" version="1">MKNCVLFHRSPTKNQKNCPLLIDTNCRMMNWKISKICRISSIHSTLLDVAYVQTKKFRHFRTFIHVLLHRMRSCQQHKVFTLVLPAVWHILVCSPHMLRPTCTVSFLHYFILFLFFAVNRFKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPT1</accession>
    <name>A0A183HPT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9492</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011683">
        <property type="protein sequence ID" value="VDO61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPT1"/>
    <dbReference type="STRING" id="387005.A0A183HPT1"/>
    <dbReference type="WBParaSite" id="OFLC_0000949201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000949201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000949201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000949201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15587" checksum="E16EF24CCD68FD3F" modified="2016-09-07" version="1">NFEVNDIQQNLFEKSRHVVPCTIASNSAYVHEGGYMTFGSIKSIRKIGTIQISIQFRPAVKDGFIFGLMTNKDPENARIAVYLKNSLMTFEFVFNDERRDLKHVFKTDLCDGAWHNVTLSISHSKMIVITVDGVCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQH9</accession>
    <name>A0A183HQH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012277">
        <property type="protein sequence ID" value="VDO62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQH9"/>
    <dbReference type="WBParaSite" id="OFLC_0000974001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000974001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000974001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000974001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="40" mass="4911" checksum="0510D8897DF0A24F" modified="2016-09-07" version="1">MRNLILDQLPSTVRFLTQQTKSERLKGVLYELKEKRRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR44</accession>
    <name>A0A183HR44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012772">
        <property type="protein sequence ID" value="VDO64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR44"/>
    <dbReference type="WBParaSite" id="OFLC_0000995501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000995501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000995501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000995501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3580" checksum="123CEB40C35B56AA" modified="2016-09-07" version="1">MDAIRKRKGLLTDELIVINAEKQRTLKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HRD9</accession>
    <name>A0A183HRD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10051</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012997">
        <property type="protein sequence ID" value="VDO65449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HRD9"/>
    <dbReference type="STRING" id="387005.A0A183HRD9"/>
    <dbReference type="WBParaSite" id="OFLC_0001005001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001005001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001005001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO65449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001005001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10088" checksum="13F6048A16C06966" modified="2016-09-07" version="1">MHPNVSTDSAINLLPVNPVLLTWEDLSVTAKKTKRLLLQDVTGIAQPGQLIALMGASGAGKTTLLNALLHRNLKGLKVSGVVKVNGRIIGRKITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS05</accession>
    <name>A0A183HS05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase_H2C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10269</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013505">
        <property type="protein sequence ID" value="VDO67169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS05"/>
    <dbReference type="STRING" id="387005.A0A183HS05"/>
    <dbReference type="WBParaSite" id="OFLC_0001026601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001026601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001026601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO67169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001026601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21345" checksum="F7AABC6E93B908E7" modified="2016-09-07" version="1">MVSTKFYWNSITSDVEQFIKQCPRCRITRMRYIASNNVPWRKGGRYGDIYTGNWDGNEDDYALSDRSSNRTWKFARSLNGGEYAAYSADNEINILPSSWKHDRPANDVMIADEMANEEIDIENDTNELGKKIPRYSVINLQKYIRFYLSQLTVQLVKCDTHSMKVIFVFEIEIIFLTDLIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSZ4</accession>
    <name>A0A183HSZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014332">
        <property type="protein sequence ID" value="VDO69883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001060601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001060601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001060601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO69883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001060601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5790" checksum="1F38A20B05320DD8" modified="2016-09-07" version="1">MKQRKAVCELVYKQEEARMLGIRRRVLSEREERKRIPEVLQCEIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT78</accession>
    <name>A0A183HT78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10687</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014517">
        <property type="protein sequence ID" value="VDO70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT78"/>
    <dbReference type="STRING" id="387005.A0A183HT78"/>
    <dbReference type="WBParaSite" id="OFLC_0001069001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001069001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001069001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001069001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14500" checksum="2E5E2577852322DC" modified="2016-09-07" version="1">MLQNLMKLDLEVLPELVAYCLDSIQRNEKFVFRNILCSLRAHLEIENLGNMETGANKKTVNLILTRIFEIILKKIKTSDGHYWKDTIAMLTTERQEQNDGENEREDIAEPEENLVPVLKKGKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT81</accession>
    <name>A0A183HT81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS10694</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014531">
        <property type="protein sequence ID" value="VDO70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT81"/>
    <dbReference type="STRING" id="387005.A0A183HT81"/>
    <dbReference type="WBParaSite" id="OFLC_0001069301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001069301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001069301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001069301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19546" checksum="247791153D6375C4" modified="2016-09-07" version="1">TAAAALEGYYKKKKGKLIDLSPQNIIDCSRKYGNKGCEGGNILSSFEYAKEYGIAKESKYPYVQTEQPCKWQKKIGIVTVKDYAFIPQGDELALKHAVAKQGPIAAIVYSLLPDFKVYKSGIYSSPNCQEPDHAVLIVGYGTHPIAKDYWIVKNRFALIHLLNYLPAYLFCTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTD9</accession>
    <name>A0A183HTD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease subunit SbcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10752</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014696">
        <property type="protein sequence ID" value="VDO71053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTD9"/>
    <dbReference type="STRING" id="387005.A0A183HTD9"/>
    <dbReference type="WBParaSite" id="OFLC_0001075101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001075101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001075101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001075101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22546" checksum="D03AEB698F57932A" modified="2016-09-07" version="1">MVKQICPSAEISSSSINNDSVFNSYKELIKRQDETIASLSQQIKKLKEDAEHQQNYDKENELASLWKQLAEQCQVSGANISRQQEIEHYKCMAVQWQSEAKRYQKWAEQWQQYQISQNSGDFQSSNPQDPVVEQLVSQNKELEEQLERGWQMYDSQGVSLAAALTEIEEAKAKIRILEGQIAQTAMDHSYKQVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTQ0</accession>
    <name>A0A183HTQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IRK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10860</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014971">
        <property type="protein sequence ID" value="VDO71917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTQ0"/>
    <dbReference type="STRING" id="387005.A0A183HTQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001086201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001086201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001086201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="3">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO71917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001086201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11226" checksum="1B2D642707633F85" modified="2016-09-07" version="1">MDDNDNHEALLGLPLIKNKICRPRLVAKNGRCILRQIGMPNPCRSFYRNWFHLVIECSWRIILCVFASGFIITWITFALIYYIIVLCDQSSVSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTV7</accession>
    <name>A0A183HTV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypoth_Ymh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10917</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015136">
        <property type="protein sequence ID" value="VDO72390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTV7"/>
    <dbReference type="STRING" id="387005.A0A183HTV7"/>
    <dbReference type="WBParaSite" id="OFLC_0001091901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001091901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001091901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001091901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16788" checksum="9704B071F95B9EDB" modified="2016-09-07" version="1">MNEVLTDLITRLSIELKLPQSERNTYALKFEDRGNDGSGVFLTKENRCLVPQGFILILTASPECYAQNLLGRLRNPSEHTGDLRTTLTELIALCGDISFAAQFMRIGGYDYVFEVIEKGLCAEYVLNFISYNILFEFAFFSSIFSNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTZ0</accession>
    <name>A0A183HTZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS10945</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="UZAJ01015206">
        <property type="protein sequence ID" value="VDO72598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTZ0"/>
    <dbReference type="STRING" id="387005.A0A183HTZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001095201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001095201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001095201"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058642">
        <property type="entry name" value="BRE1A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26052">
        <property type="entry name" value="BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRE1A/B-like" evidence="8">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO72598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001095201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23191" checksum="485B25F913C48106" modified="2016-09-07" version="1">MKLVDCELTRLHIFRQQIETAKSQLAALRSAHSKQIEVMESEECQAREQMQDTMNRHEEELYQVRREYEMLRLEFEQNLSANEQSGPLNKEIRLMLASAKAENQQLKQEANRFKRKWKEAVSSLAKCNKELESERRYRERCLLIEIEDDNDALASPDQDRNIAEPSESILHDGGSCEYNNEIDGETDVGAHPNRVIQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU86</accession>
    <name>A0A183HU86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015458">
        <property type="protein sequence ID" value="VDO73432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU86"/>
    <dbReference type="STRING" id="387005.A0A183HU86"/>
    <dbReference type="WBParaSite" id="OFLC_0001104801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001104801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001104801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001104801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15282" checksum="48B2330AE1556508" modified="2016-09-07" version="1">MKRKGDDTLEQIDRKREKRRLICMQIDDYIEEIKLPSTKRCKLEALAEFVKNAIYAAEESENAFQMDDLRELHLGKIQFPLSLPFDLELSSVKSSCDCRWIHPDKIDTLGSWHVGHQTKMEPILDLIVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUK5</accession>
    <name>A0A183HUK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11165</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015781">
        <property type="protein sequence ID" value="VDO74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUK5"/>
    <dbReference type="STRING" id="387005.A0A183HUK5"/>
    <dbReference type="WBParaSite" id="OFLC_0001116701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001116701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001116701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001116701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17558" checksum="1138546F67130883" modified="2016-09-07" version="1">VHQCHPWYFTYCWIVFTYFYAILSVFVHSSSLWLTVNMAVLRYLVLKRSSTSTSKIPIVNTFKAAFIAIIAAIIISLLGSLPNMLRYQIRDSGFLNVPPYCIANQSAYAHHYTDNPKVHAYNIAQPSWWTCRWERFNFWAAVHKRVISKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUP2</accession>
    <name>A0A183HUP2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS11203</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015886">
        <property type="protein sequence ID" value="VDO74693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUP2"/>
    <dbReference type="STRING" id="387005.A0A183HUP2"/>
    <dbReference type="WBParaSite" id="OFLC_0001120401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001120401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001120401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO74693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001120401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9728" checksum="0851E7B6295B94BB" modified="2016-09-07" version="1">MLGFLVQAIITRWQRMIHDIGFIDSLSLTIAGYIHDNTDYCRMIRRNIVRYICLAQLLVSRELSIAVRKRFPTMDSIVSAVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVP3</accession>
    <name>A0A183HVP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016821">
        <property type="protein sequence ID" value="VDO77350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVP3"/>
    <dbReference type="WBParaSite" id="OFLC_0001155501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001155501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001155501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001155501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13381" checksum="BA54D1555DB2C51D" modified="2016-09-07" version="1">MYSMTNSTHSTMTTVVKCAYDDFSTPTPLRSARVIVEGEKACNSSRTVYVNPGWLAEFSNFFVMVFFGKNAGQDLTLDDEVSYEHFIELLRVVCYCPTRKPITGYFLFYSSFYSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVT4</accession>
    <name>A0A183HVT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11595</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016943">
        <property type="protein sequence ID" value="VDO77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVT4"/>
    <dbReference type="STRING" id="387005.A0A183HVT4"/>
    <dbReference type="WBParaSite" id="OFLC_0001159601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001159601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001159601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552653" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001159601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7819" checksum="46587710FB763680" modified="2016-09-07" version="1">MTLLIGLFLILKAEALGALGKVDEAKEQVRQADKFKQERAALDRLLAQSANPTSHIEDLANQLSKPMEVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWD4</accession>
    <name>A0A183HWD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11798</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017540">
        <property type="protein sequence ID" value="VDO79337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWD4"/>
    <dbReference type="STRING" id="387005.A0A183HWD4"/>
    <dbReference type="WBParaSite" id="OFLC_0001179601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001179601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001179601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001179601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14737" checksum="0EDF786A7E3B2478" modified="2016-09-07" version="1">MRNHLKECLNTVIDATFKKGHECESTGRLTRKRPISYEQLYPSLFSRRRKSSTMKTPTMTQLNIFDSVESDNVQFKSGTGDGDVLSECLPSKPKRKRGQNSISDNKYADDKSFSEKMGLDKSIYDSGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX56</accession>
    <name>A0A183HX56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynactin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018263">
        <property type="protein sequence ID" value="VDO81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX56"/>
    <dbReference type="STRING" id="387005.A0A183HX56"/>
    <dbReference type="WBParaSite" id="OFLC_0001206801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001206801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001206801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein associated protein" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001206801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11700" checksum="A26AEE6D6D466443" modified="2016-09-07" version="1">MRREHVTKSHKAEQWAQCAKFNYLLNALECVLRKFESAVQHCSVERLSRLAQLQLEMAAQERMIDQYIDLLKTDHLDENTSSANLEKGITYFQELFGILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXN2</accession>
    <name>A0A183HXN2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS12241</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018761">
        <property type="protein sequence ID" value="VDO83136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXN2"/>
    <dbReference type="STRING" id="387005.A0A183HXN2"/>
    <dbReference type="WBParaSite" id="OFLC_0001224501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001224501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001224501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO83136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001224501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8673" checksum="B5CAD637F589A907" modified="2016-09-07" version="1">MDKSSEQLKVNKWDGPSVRNTIDDAIRKVFNEKYDNWTERHTLADGRLIISTVAVAFAAFALIYDYYESFPKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXX6</accession>
    <name>A0A183HXX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12336</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01019051">
        <property type="protein sequence ID" value="VDO84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXX6"/>
    <dbReference type="WBParaSite" id="OFLC_0001233901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001233901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001233901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001233901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="32" mass="3787" checksum="88F364B25AAB8B31" modified="2016-09-07" version="1">MMSRKVAFLQRIHHLLVNVVQRKVNIEQGLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HY60</accession>
    <name>A0A183HY60_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12422</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01039839">
        <property type="protein sequence ID" value="VDP11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HY60"/>
    <dbReference type="STRING" id="387005.A0A183HY60"/>
    <dbReference type="WBParaSite" id="OFLC_0001242301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001242301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001242301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001242301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18477" checksum="7CE14FDD3D8915C0" modified="2016-09-07" version="1">MLVRRFCRQEHSVEMALKRIQKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPESPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRERYNQLAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYM4</accession>
    <name>A0A183HYM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS12586</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039875">
        <property type="protein sequence ID" value="VDP11680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYM4"/>
    <dbReference type="STRING" id="387005.A0A183HYM4"/>
    <dbReference type="WBParaSite" id="OFLC_0001258701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001258701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001258701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP11680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001258701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11645" checksum="3DE31D55B8F21575" modified="2016-09-07" version="1">MVGIETALKLDDLNCKPQIEYENCPVCGDRVSGYHYGLLTCESCKGFFKRTVQNKKPGLLKIRFQSYQCSADQNCAVDKSCRKRCPHCRFQKCIQRGMKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ20</accession>
    <name>A0A183HZ20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039917">
        <property type="protein sequence ID" value="VDP12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZ20"/>
    <dbReference type="WBParaSite" id="OFLC_0001273301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001273301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001273301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001273301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7652" checksum="C2CE2BF204B8B362" modified="2016-09-07" version="1">MISKNYEVITRNGTFHDVDVNHAATFARCDKIDGTDKVGIEQASCDWTFIPIFLPKTRKCLRIFCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZT5</accession>
    <name>A0A183HZT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12997</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040005">
        <property type="protein sequence ID" value="VDP12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZT5"/>
    <dbReference type="WBParaSite" id="OFLC_0001299801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001299801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001299801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001299801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14217" checksum="8635044E5074D9FB" modified="2016-09-07" version="1">MIIQDQDFTDYHVILTHHQRLKSSDFVESTDTFSFDIPIVPIDLSLLDCHRKPHPSRRLPQTSILSSLSTASSMPCRHHWFRLALSLLCINFAFSSNVNGFVVVVVVVVYRMKSCQDRAWRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0F5</accession>
    <name>A0A183I0F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLM10_mid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13217</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040092">
        <property type="protein sequence ID" value="VDP13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0F5"/>
    <dbReference type="STRING" id="387005.A0A183I0F5"/>
    <dbReference type="WBParaSite" id="OFLC_0001321801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001321801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001321801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF4">
        <property type="entry name" value="DUF3437 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001321801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="987" mass="114736" checksum="FA3B6DB98628BD60" modified="2016-09-07" version="1">MWTTDDRYDDEKKTLKEKQSEKNGYIYTSAEGYLRDKPKFQRTRREYSYLPYYETINRNASCWLEQIKAGLAASTLSYVADSGLSFWMSQLSQYLNRFYCRFSKADHIKLIEFIFNIILEPDYDRRLIHKACSLIITLINEEIIKRSDLTLSWRPLYDLYIEVTYKRNSKNLEKSVIRSAVLACKELFPLSATKEILDEIRPFIDLWNDYAMTKFVTIFSIFVPLKMSNDEHDRWGAGLWYDELWYFYNFIEMNGSWESRIQHIFSAISEYCPGYIDWSSKHTIIFSKLLRSLNLSVRYNKVTIGDGTGMGSESSGAEWIVWMLGGMNESAHQCFERLIKCVESFLHPLHEGDHMPTLQSFLDALVNEMVRRVRIERVRKKTRNKVPPKMRLTDEQIEWFVSILLPSVLYSVFSTTETSASSIMRNLAFLAPQLVLPKCLDLIYPSLLTITEPHRLKQSLECIVEICVPLVRDNGAYSYRTYNVCKQVWITKMNKITEDRKRESASLSIVNESETHSDRYRTLETIFHLIPIVNCSLALEMEEYMDLAEEEKELCKLTSRFPNIVQDFVNKVFKVITQLASSAPSDCVSYMDSICDNSDILLAGTEEIEISKSIQSAFHALFLHCSSTFVELIGDQTYKFISTSEFENVIAADAACSLIQESTYANPTRYFPMYIKFLLEKQKQHITEEKKILKELDATTMWFTYLSEMIFSVPSDLLLKYQEECIQMHKCTISMMCYNAYQGACWSLKNLLTQLIEIYPISEEDRQHNLDLPLHLSLPIKDWGINCPKDIVTIKWHIPTDAEVDFAEKLLNEFAYSEIQLLTTPQNMDKFAIKRSLFVIDSLLSCVGNRLPSFNAPEIKLSETAVDMNPIHISSMSPLFSINGENIREVVRVTIHNLMEFLLNQQDDQSKNLLLISSILQMLCTEGSLPSFRASRKNIKINYNDPIRGRRAELYDDLYIKNSKFTESHLKIMKDLVKLGTNFFTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1A8</accession>
    <name>A0A183I1A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13520</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040241">
        <property type="protein sequence ID" value="VDP13966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1A8"/>
    <dbReference type="STRING" id="387005.A0A183I1A8"/>
    <dbReference type="WBParaSite" id="OFLC_0001352101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001352101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001352101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01756">
        <property type="entry name" value="PLAT_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="512"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="649"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP13966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001352101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1065" mass="121397" checksum="83FB87CE4CD50BC9" modified="2016-09-07" version="1">MSDPDNGDNTLLWSSSHSTPEQHLTPDIVNPHPPNVPTLPNRQIQNYRTSNRSFTRPYSAKTVFFYKEGDIYFSGLRVPVSKARYRTIESLLDDLNSNISMPFGVRHLTTPRGKTMIKSIDQLQHNGRYIASSIKTPRPLNLSMVEKIQRIRRANRVHMFHHYRNWFNCWKDRISKNQNKSERVKIPLKLSLIPITSKQILFVLNGKPSRIYRALLNPSRKQTIESLLEEVSEGLQIAIFKLYTYSGKRIISMDQIFSLNEARLLAVPRNERPIFQENIFPMASPLPPISRMTPSSLLGQSTSGKQVIQSVYRENSIERPQRVINNSKMMPLTSMSRLNRRESNDSKNASLTNETKKRSPEVSQHSPVLSSPERSPETGEKTTGLCNAECHKNNELTENDIREESCASKLTESDDEKEAEDDKKEERNDEENETNIAESEEEEEAEEEVLVQNNEEIEEHEAMEEQKTNTAVKEVRELMLATSNDQALDNNETTTTTAPEADFSLNAEENGMTYTVSVITGNRWAADTDLDLFIILYGDLNKSEKHLLRQDKHEPKFQQNRMDSFHIETTKLGLLQKILIGHDRIGYGAGIYIERILVTENIADGRQYLFQCAKWLDSGQVDGKIERTLKTTAFCYLTTILRDSKSTSGRWELILHSGKSDGSGATTSNLNIVGYGNQGSSITTKIYDNRMAKVPSASLVQISFEIPFLTFILQTTEILKYKTVDFGKIGDLLKVRIEIDGNGEIPNYYLNYVELRDLDTEERTVSYVRKWLKIGCDEKNAQSFREFPVFRAAFEPLNVLSYEGKIKLSSRKQRFLKKSIAYVRIFGEIGETGYFPVDFRCASDLKQELSFKAEAVSVGRIQSTRLYVNMNDIGNEIYEGMQMLQSIYDRQHVTSVSVASDWIAEKVVVRESHHAPYRYVMAVTRVKSMKEENEEVEDDDIYNDIGDVFVELLLSEMEGLSTKTSKKKALSKKKSQWILSMTIGEGSTLIPRITLCAENASAEMTIVATTPTDMIITFQQKAADLSTITKVRIGVDDSQRLNHIPTDDVKVDKENIIEIQKACDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1T7</accession>
    <name>A0A183I1T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fcf2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS13699</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040345">
        <property type="protein sequence ID" value="VDP14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1T7"/>
    <dbReference type="STRING" id="387005.A0A183I1T7"/>
    <dbReference type="WBParaSite" id="OFLC_0001370001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001370001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001370001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001370001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25487" checksum="1B08A3D6904016D3" modified="2016-09-07" version="1">MFQEVKTNDLFVLDVDGTSNIDMNVARKPFFTTKCDVKKSKTLDTDSILDKTTKELLSKSIIKPGFEKYLGEGHMPVSWRALKKQRKMDRERTKGDAWYNLPAGEMTEKRERDLKIIQMRESLDSKAHYRKNDRSVLPKYFQIGTIIETKADFYSSRIPKKQRKKTIVEELLADTDLQTKQRQKYQEIKAREAVAKRGAFQHSSYPKKRKFRQNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2M6</accession>
    <name>A0A183I2M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13988</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040519">
        <property type="protein sequence ID" value="VDP15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2M6"/>
    <dbReference type="WBParaSite" id="OFLC_0001398901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001398901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001398901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552745" evidence="2">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001398901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5111" checksum="37A2EC1DE68934E9" modified="2016-09-07" version="1">MVYVITLLAATQLPVAYACIASPQVITPAPTPTTTPTPTRPPTPTPVPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I388</accession>
    <name>A0A183I388_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040666">
        <property type="protein sequence ID" value="VDP15914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I388"/>
    <dbReference type="STRING" id="387005.A0A183I388"/>
    <dbReference type="WBParaSite" id="OFLC_0001420801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001420801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001420801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001420801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13405" checksum="93B223D3BDAC7E76" modified="2016-09-07" version="1">MDGPYLRKPRIVYRTGVPNPLTLDQYSAVLDKVEKNRNLVCTNGPMYRPDGGTIVVYDCTLYPRGTLNDDQVRRTFRVDGYRWGNSKGVHNLSNGLQKRYNLLYCKNDSHGDDRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I392</accession>
    <name>A0A183I392_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Folliculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS14204</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the folliculin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040671">
        <property type="protein sequence ID" value="VDP15940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I392"/>
    <dbReference type="STRING" id="387005.A0A183I392"/>
    <dbReference type="WBParaSite" id="OFLC_0001421201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001421201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001421201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1730">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044886">
        <property type="entry name" value="FLCN_DENN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032035">
        <property type="entry name" value="Folliculin_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16692">
        <property type="entry name" value="Folliculin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="17">
        <location>
            <begin position="87"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDP15940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001421201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68800" checksum="8FDBFB1BCA5BCB73" modified="2016-09-07" version="1">MQAVLALCYFCETHGPRVLMTTQSISEKLRQDYCLPTTSKGLSTFVSAKSFRTRLTEESRCVACTSFIDGAGVITDDIEVGISYITTQVALNDRVYNLVKYSCLHSLSCEVTTTPKDNIPKLSPIKSRAVQIPESNKKWESPWEEANAEAKDGVILFGDDEHGYTLSYTFRLHDYKARGFSRFLSLILVSIDKLFITSNFHFFVSTMSSTIRFLQMESNMVFDREQNDPSNEVLKQAAASRASLLPAHFLRTYVTKLELDTSRSLAVITGRADIFTQLHMFMVCILRTQTRLCKEYLLEGVPTQDMLVMKERELKTDDGASAYDISCSRCLDCFETLRKIAHMLENLPKINGQSVLEIVLTQLVTGGQIVLKCRNEALSKRFLLALSSLLPLGCVRILYSEEYRHVFVSNLFGCPQETELSPDAIDIVVLLLDILFDRIHSRQPMAEERETCSLSSGSCISSPMSTSPKDDNVDESLAKHLIEILPPTKSFDFEDYVFTLIAYPKYTAPKYGTPTIVNRYKQLILDDDLSFRVLASVVGNTREQWLNKAKLIYQLGRQKEGIDLKKVLQIMKCTKEDGTVLLFFQAGLSYTYKQQVMGVIKKERGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3H7</accession>
    <name>A0A183I3H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14289</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040741">
        <property type="protein sequence ID" value="VDP16353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3H7"/>
    <dbReference type="STRING" id="387005.A0A183I3H7"/>
    <dbReference type="WBParaSite" id="OFLC_0001429701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001429701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001429701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001429701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7844" checksum="E44A2D03D4FC5118" modified="2016-09-07" version="1">MPIAAFSVLNANISLPIERILYLYHAIFLFIEIIAGFLMIRKISRYQMARFKERVLEEDEPKNRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3X6</accession>
    <name>A0A183I3X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040855">
        <property type="protein sequence ID" value="VDP17046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3X6"/>
    <dbReference type="STRING" id="387005.A0A183I3X6"/>
    <dbReference type="WBParaSite" id="OFLC_0001444601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001444601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001444601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001444601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12217" checksum="CAD9C28D0A9DB8DA" modified="2016-09-07" version="1">MRARHSLASMGSSVLSGITLTKFGGILVLAFAHSQIFKVFYFRMFLGIVLIGAAHGLIFLPVLLSYIGPPMNKRKLIMKTRSESCCINDCSGAVKKACLTKHCDPSPLPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5V7</accession>
    <name>A0A183I5V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15121</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041641">
        <property type="protein sequence ID" value="VDP20490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5V7"/>
    <dbReference type="STRING" id="387005.A0A183I5V7"/>
    <dbReference type="WBParaSite" id="OFLC_0001513001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001513001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001513001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF14">
        <property type="entry name" value="FOLLISTATIN-RELATED PROTEIN 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP20490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001513001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17710" checksum="E762C21AF8A5F24F" modified="2016-09-07" version="1">MIQIFKNETNASFLYALMACNQTHQLTSINEKSEESMIDNQIECPKPKSCHGLRRPVCDSNGRWHRNQCTFLRAQCLAARRGEHLSLADTKLCSTNSQKKEAKKVSASNRCYRRCPANLTYEPICTTTFVTYPNRCLFLNAKCRDKSLEQLYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6V5</accession>
    <name>A0A183I6V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042195">
        <property type="protein sequence ID" value="VDP22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I6V5"/>
    <dbReference type="STRING" id="387005.A0A183I6V5"/>
    <dbReference type="WBParaSite" id="OFLC_0001547801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001547801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001547801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF282">
        <property type="entry name" value="CUTICLE COLLAGEN SQT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001547801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="18170" checksum="55E0AD3FB5D10245" modified="2016-09-07" version="1">MLSETIQPQFHINLKQQQQQQQQMDTKTKHGPLGALGRPGPRGLSGNRGRAGLPGRNGSPGLPGEPGSPGPRGPDGPAGPPGVKGEDAEQPVGRPGLKGEPGLPGPSGPPGMSGRHALSGPSGPPGPPGNPGLRGPQGPSGPYGEVGLPGKDAEVIILYCSYPERQESAIGYAKQEKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7C4</accession>
    <name>A0A183I7C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS15636</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042515">
        <property type="protein sequence ID" value="VDP22976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7C4"/>
    <dbReference type="STRING" id="387005.A0A183I7C4"/>
    <dbReference type="WBParaSite" id="OFLC_0001564901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001564901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001564901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDP22976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001564901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22806" checksum="8E227EC128FCF9CF" modified="2016-09-07" version="1">MRGEDMKCITEEEYTKLMIFFCNFIHAIGMDSQQPHKTRMQVIATACVYFRRFYARRSLKDIDPFLLAPTSLFLASKVEEHGMMSHNKLIQATNNALKRWPFIQQDLMIRVQHIQEAEFFLLEILDCCLIVYHPYRPLNQLIAEMGREHKDLDTISSYAWKICNDCTRTDLSLMYPPHQIAIGKFDFVSRKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7G7</accession>
    <name>A0A183I7G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5683 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15678</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042606">
        <property type="protein sequence ID" value="VDP23189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7G7"/>
    <dbReference type="WBParaSite" id="OFLC_0001569201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001569201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001569201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001569201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10686" checksum="3D4A1DAC26C8E0B2" modified="2016-09-07" version="1">MEKFNEPTTYAQYVKFRMGKLWSNTKQIYGIGFIRKWSLWWAMTTCMSLQISAYSQTLWGEVQKEETTLNGFAEATYTACGKYFKYFINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I874</accession>
    <name>A0A183I874_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15936</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043309">
        <property type="protein sequence ID" value="VDP25151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I874"/>
    <dbReference type="WBParaSite" id="OFLC_0001594901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001594901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001594901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001594901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="4483" checksum="FCA15AF7D78B893D" modified="2016-09-07" version="1">MVERTFENSRTRRTPETLKSKPTNKFWFYLKMTNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8D7</accession>
    <name>A0A183I8D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043546">
        <property type="protein sequence ID" value="VDP25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8D7"/>
    <dbReference type="STRING" id="387005.A0A183I8D7"/>
    <dbReference type="WBParaSite" id="OFLC_0001601201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001601201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001601201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001601201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6796" checksum="96683492D2F0745C" modified="2016-09-07" version="1">MEKCIFCGWYRRTNGPALRFYGIPREPGLKRVKWLCAIGDRELSPKDKVCSFSHISMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V4I1</accession>
    <name>A0A3P7V4I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000682">
        <property type="protein sequence ID" value="VDO29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="82" mass="9269" checksum="40ED26F63307BA02" modified="2026-01-28" version="1">MTCVHTLTVIPNCEKSVLGQVKGQAPSDVNHPHLKTSANRYTVTAYCSTEYCSSVKHCIEVFVHKLGERESFRDRTEFQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W6X1</accession>
    <name>A0A3P7W6X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002998">
        <property type="protein sequence ID" value="VDO38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H9E6"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="136" mass="15733" checksum="DD58334DBBDABF59" modified="2026-01-28" version="1">MLFKWNQKMAEDEDYEGEMDGDEYGDEEQMDDLDLEPAEDDAERIQVVEGSEKTASTERVTTPFMTKYERARILGTRALQIAMGAPVMVELEGETDPLEIARKELKHQKIPLIVRRYLPDGSFEDWSVDELDVTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XUZ0</accession>
    <name>A0A3P7XUZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001407">
        <property type="protein sequence ID" value="VDO33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XUZ0"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20924" checksum="D2D7C0746576F23B" modified="2019-02-13" version="1">MQFSKADDRSLERKIDEFLVLIVCQKFGRKDGYHSPWHLPQLRNLPSESLKQTSKRCLKELFSAEMYGKGISNAPFSVYFYNYPAQLRQRLKTQSRGAAIFFFKALYMKRVPLVVNGDEIADYKWVSAEEFVASVKHKISYLRALSTLFPSSLLGKNSFECDKRTGSQKTRLKTDIQMQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XYS3</accession>
    <name>A0A3P7XYS3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001811">
        <property type="protein sequence ID" value="VDO34668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XYS3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF22">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36846" checksum="A42169A505BE9541" modified="2019-02-13" version="1">MNHICIELFYSSIKFQNSRSTVSDFLHNKSQKVYILDEYGRPFPFTFIQKRRIQRSIRDDQVFANRLLQTLAPLRRQKNKKASLVIFDKDGTLICFHSTWVPWAINVTEKICEAINMNVEKEIYSLLGLQKEQQRVKSGLLAEGTMAQIHDAIARLLINRGIETAEAVKHVMVAILESNESSRHNVKEIFDLRSLFRQLRDNGIKIAICTSDSRKGTLTTLQRLQLEDYIDMVVCGDDAGSMPKPHPHNALSICRMLDVDPQDALVVGDTLADMRMGRSANLGSTVGVLSGVCGINELRPQADHIVRDVSELLPIVLDMRRWSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YD32</accession>
    <name>A0A3P7YD32_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012160">
        <property type="protein sequence ID" value="VDO62503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YD32"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001749">
        <property type="entry name" value="Neural/ectodermal development factor IMP-L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO62503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="201" mass="22852" checksum="0576A93892C91D0A" modified="2019-02-13" version="1">MKVEQEYFVNLFESKSSCICCRIYNDNVIHAVNESNAVEKLYNVGLNTIQLAVTASKILVPCNGTKNTAEYKCLANNGHQKLESTTTVAFLSFFTELSEEKAKCSRKHSPPTINVWTDSRFERSGATVQLFCRINGTPQPSVTWYNEENHKLNDVKKYKILSNGDLIIYDTQWEDLGVYTCVASNEYGEDRITAFFYPTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AV48</accession>
    <name>A0A3P8AV48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040332">
        <property type="protein sequence ID" value="VDP14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I1S1"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="440" mass="50298" checksum="3ADD0E06D0E67138" modified="2026-01-28" version="1">MNSENERSQILMDETIDDAMNDGPSSRIAECEPIQEQIRNCDPDDSTMVKVELSDTAVSKTSKSLKALFEQQEYEDMRNTSWADLMEQEVTKSRNGLQLKRDEEVAISKTESMESNCIVLSSGEEYPSLSVSTKQLDTERNKVNISKKKRGTKSKFECNSELTETLANQAPKIKGQDPGKAFRRAVKRDKTRRIQAFSVTSTDDEESPISSKYQKKRRKDIYKEKIVCEANNLRFDSKDLPLSDIKRSSRESSPGSATSTTSTLRIKKGWSEPKLGWCKDEVTLLRRSKEIEKAKEKPVYLKYLKKVPRHARTKDMPKTPNKYIQYSRRSWDKQVRLWKRRLYEWADEEPTQSCLSLNESTSDETSDSEAVSSFPATLMPNENKLSLDEIKVEQDAAASLLGYLDIDTRTNTLTVMKIDDESTLKGTSRNILGPRDFSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8BNN5</accession>
    <name>A0A3P8BNN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041295">
        <property type="protein sequence ID" value="VDP19290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I550"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="64" mass="6944" checksum="6BB11CD4C882EE32" modified="2026-01-28" version="1">MSGRQGGKAKPLKKPKKGQKELSEEDIAFRKKQQEEAKKLQEVQAKAAQKGPLVGGGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8C8U5</accession>
    <name>A0A3P8C8U5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017892">
        <property type="protein sequence ID" value="VDO80562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8C8U5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="175" mass="20145" checksum="FB85674C56B39003" modified="2019-02-13" version="1">MFASRQSWQIKLSDFASAQKLTSEIKQPSKPNVYWASPEILRTDNKKTPITGQTDIWGLGMITFCLLSGFHPFASEDDSEDEIKESTIYQKCNPNLIQIQATQESLKFVTWALKKDPMKRMRTDEALTHRWLSMDAVMIRRREAINYPSSRLRKTAILTANRIKGNPPMNHFGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CNC3</accession>
    <name>A0A3P8CNC3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS15582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01042404">
        <property type="protein sequence ID" value="VDP22698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CNC3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP22698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="277" mass="32233" checksum="2826701AF3081F23" modified="2019-02-13" version="1" fragment="single">MEIFLRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALSGNEDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYIGTFWDHPLHYDINRRLFQDEQHDLFSDLQALPRNAALRKLNDLIKRARLAKVHAYIIAELRKQMPSMIGKEKKKKELIQNLDKIFEQLQREHNISAGDFPDINKMREHLPDYDFTKFNPIKPKLLDVVDGMLASDIARLMAQIPKEENAPITNGLLQPHQTEVRGGAFDQAIESETPFGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXY8</accession>
    <name>A0A183GXY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0020 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS98</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000023">
        <property type="protein sequence ID" value="VDO24522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXY8"/>
    <dbReference type="STRING" id="387005.A0A183GXY8"/>
    <dbReference type="WBParaSite" id="OFLC_0000009701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000009701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000009701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF1">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000009701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38467" checksum="434EC9BD37297D13" modified="2016-09-07" version="1">MEPFVKKQLGQIQDVKIDETIMEGKILFDASNSDKLNSLRCAERLFLVVANEMIDCNWNKRQLFDKLFSLFGRNSLLNSACEAAFNCMLCCGEPSRSRTFRVSLKATGKWRRKIDTEKLSTSIACHIKRMSSFKNSLHFAVIEVCIHLSEKYIFIGIPITRERLSQRRYLLNNALRSTVVDAMLSMANIQDGDIVADLTCGSSSILLQTAHEFQDKGSCILNFVIPVFLLGIDFCWDALQQSQKNVDYLRKNDNAEPSIDLLCMDLFSDCLKYVVVDHIISDIPFGQRYGTDQSALQTLQRICDIFSKYVFCLNFFSKICKIHWEANLLFGQIKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY42</accession>
    <name>A0A183GY42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000038">
        <property type="protein sequence ID" value="VDO24745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY42"/>
    <dbReference type="STRING" id="387005.A0A183GY42"/>
    <dbReference type="WBParaSite" id="OFLC_0000015101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000015101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000015101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000015101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26453" checksum="9AE2ECF7289C0143" modified="2016-09-07" version="1">SLACSALAFFFQARLTFQFFYPSLICTISSIIFFAKPFMKDILTKWQYVFLHLIWLCNHMCNPFIYAYFNERMRLTYEQWLTCAPFRKCIRKLKKQHSRKHGELVRGSKRLNTAAASMTKNSHWRNRTNQSDNFVRLSLQMQSRDFEQFCEVMMSVNTANESSEGWTESSSDTEAEPINATIDASQQTSSRRNNIPAGKGMELNSLVFDLGRQTVEHWAYFAKKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYC8</accession>
    <name>A0A183GYC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS238</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000068">
        <property type="protein sequence ID" value="VDO25096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYC8"/>
    <dbReference type="STRING" id="387005.A0A183GYC8"/>
    <dbReference type="WBParaSite" id="OFLC_0000023701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000023701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000023701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000023701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61988" checksum="D9CAACDACD97E7EB" modified="2016-09-07" version="1">METTLTTCPQCTVYNEQLNNKADEIKILEEHVLKLAHKLQDESRTKEEMQERLNDKLMRLNDYAIRIRSLEEQLQSATDRRPISELSRAEVDSIIGRDLERIHSQLIEKDMKIIELNDTILEKERHIIELQEMCREQGELVQAKAKAFHIIQQKLQDLDTRTTREDSTETEAAYVFEPGFIPLSSLQQPQKEQRQQRDSFSPGHAVVQFKMGSSGSPPPVDPSEECSSITQSTSNIQDDHNGDSGGNTFSLQKKKQRKKVTFDLPPRREFKSGSGQEEDDNITQAIVDVTAENDQLRQTIQEMEKYQMFCIQFNFQLQTQLDEMRRDGRNQILKARAAMQGRIRDLEDKIATMNTEYTDKIEHLNANIETLRADREWTLEENTRLLKLLSSNKYPFKEKLNDAWEALDAKQKETMKLRSKLDDDRALIVQLADDLEEAQQTADILLEQKISVLDDVERLKEALEAQDQYIELLEKDTMIYEEHVGLLRDSLGASKAERRALIKSKAYETKLKALEQEKEQMNRRCNGKLNFLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYH2</accession>
    <name>A0A183GYH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS282</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000082">
        <property type="protein sequence ID" value="VDO25249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000028101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000028101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000028101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07385">
        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="183"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO25249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000028101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46820" checksum="0B4FB90B807FC78D" modified="2016-09-07" version="1">MVLTRLNIVFLQQIVLICGSVFIWWNLSPAFDRVCSALGNLTIQPSYNHWLTICVQSVLKVFVILILFLAHICSVFYYLWIGEEPNIFAMIALTSVAVHIYLIFFLLVFLLMQSIFRFILRADSKHFKILRWLVANELSNRLYTIVLAVVIVLGGLWAALLPPVVRHVTIKVENLPDAQKGFTIALLSDLHIGPTVGRSNIQKMVDIINPLKPDMIAISGDFADGSVHSLERAAYPLSNLTSKYGIYFATGNHEYIHGNVDEWFVFLKKINIIPLHNKHKKIWVGNSRICIAGADDLFAKYSRLAGHVMDYKKALRGCSKNDTTIMLIHQPNAARIILKDTETAKNVDLILSGHTHAGQLYIFVPLVYFWNAYFRGLYYNKATGTHIYVSAGVNYFGPPVKIFDGNEIILIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYP1</accession>
    <name>A0A183GYP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS351</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000109">
        <property type="protein sequence ID" value="VDO25496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYP1"/>
    <dbReference type="STRING" id="387005.A0A183GYP1"/>
    <dbReference type="WBParaSite" id="OFLC_0000035001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000035001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000035001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="698"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO25496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000035001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="916" mass="104692" checksum="07BD4EA2544C7D03" modified="2016-09-07" version="1">MDLKRDISRNSMMKSNNADNSVALVTSMISGNIDHYDPCDRSLLVQSMCVGSSDSYVTQKVRERRSLPKPPPPIKPTALKNKIAHRTIQNSIPSVSKLEVSITDGNLLKVPPNTSEAKTHEERNNCAEKIVSEDTATESDVSFEAMRITEEVKGVEDEKESLTSKSAQMSNNKTTATIMRTSFINEEIKKPKMKPPPPPIQPRSSQSGRNSSKIETIRKKLNLEGIFCTDQDVVQNTVIDGENVRSNIHRFERCIDDNWHIPSVPSIPPPLPPIFSPQDSINDEMYEEIEQLTCYEYLGMSYSRHTNEINSDNFYSGQDESYANEEEKKLSDSNSACSSSNHFGTMLQVPNKEKHYVKNHEKAMKRPKSALEFDKLLRIKSDIQLNITKKVGQIKFKVSSASQERQRYKRFSSILYTDREKLKDHSDDKVLAKIDFPLDEQCIYEEAKNQSNKVVDVGKGMSNGPYSMLSEIERELRLRFQAHDNLPDVVLESRRRSMSADQLLCDTKATTKIENASRSSFRQIQRYNEDNNLGICCQTKSDCLNPTIDGYETLISSIQSSPEHNYLPSTSSDYTLKEIDRSIYTAKIIPDPQPLYQIYMMEQNGRLIYETEEQEVTQPSLSRMNISTIQRATSSTSTDSGRGADCSTTKSQLTSNTSMRRDRLVASSHFASQRSLWCELPEVRNAGLLEKLDEDTKKLQEAYFEVITSEASYLRSINILITHFMAAPEMLGSKRPSSVITNEERKQLFSNIFAVRDCSEKLLSDLENRLQESLVLSDVCDILCDHFETNFDSYIKYCSNQVYQDRTLRKLKSGNSSFLSCIQRLENDRLCQGLDMRSFLMLPMQRVTRYPLLMIAILEHTQQDSTNYQTAQIALHLANRIVTYCNEGARHMERIEQLLEIERRLIYKSSDLRYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ50</accession>
    <name>A0A183GZ50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RhoGAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS510</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000175">
        <property type="protein sequence ID" value="VDO26055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ50"/>
    <dbReference type="STRING" id="387005.A0A183GZ50"/>
    <dbReference type="WBParaSite" id="OFLC_0000050901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000050901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000050901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08869">
        <property type="entry name" value="START_RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF7">
        <property type="entry name" value="CROSSVEINLESS C, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="727"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000050901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132553" checksum="AB7493C250A852DE" modified="2016-09-07" version="1">VAISNKWKYQRNSQTWSRIVRDDDTPGDSAWSSHKEEVSGAELNEASQMSFGYGQNPRRQPDGAPRSNDDIYNSRNQRGIPANLVTARSNRKNCFAIDSSSSSPTAIPAVNLQRSQSERLKERARALMKRMNIRSSSRRRRQRNSSVADSAFSSTAGIPHSSPSSTATSSLSKAISSTGSRDLVIGDPVLVSHFSASPRTMRMFPDGLSNILSSQAVTPQMLNKFRRDSTATTTDDHASDGVTFAVLQPMRQQQQMMSDSDSASPQYNNSSSSSSRIRTRFLGASNRRMGMVLDSSESSAPITTGHPSRHESICRNKSRDLSCDPVLIRGLPRHDRNTRIYDRVAQDLCADNTEYANPRRGPVDLEATTYYDRCPTITRNERASSSQYCYANKSNFSSSIRSDLQFSGENVLSDNSLNYDELKGHPRQHMECDRDRGLASEQSYVRSRLVVNADGYYEHIPSDDVHDISLDLAAFSSNLDDSVVGSGTSGAAVSIAACHRAVSPESSSSNTSSTIHPNRLKTEIDGRSGKRLVCGSGSSSFSAIRGMSTQRSHSSLESSGNDDELITRQHRSGVGERRDSGVGSSLSRSPSGPTTQRQRNSLLFTSTPTTLHIREMKVKHLSPNPLNSFRADFNETFISDANLTQCMDALSVGEMQQIRKLAFLKLSVMIETYAGSGIRIGVVADNNDSGRVSKNWTVHKFIRRMRNNDAINSTSKPTGTELSTFGLPLAAIQSRSGFALPRFVLEMMYFLRIAAPDTVGIFRKSGVRSRITELRMLCDVAPEAEVFTDGKLDLSQVHDIADLLKQYFRELPEPLMTAKYSETFAKIFIYIPMEMRMEALQHAVLLLPDEHREALQTLLYFLHDIAKHSATNNMTSQNLAVCFAPSLFQLCGSRLNNISPTRRHKTIGAAGLPTEREIKESRAAQECLVQMIEHCTKVFIVPASPGFERDRGNEYCKGTERDAPFLAELGLSQDGNYKTYLLQKARELLKEHRDRWKGWIVEGTVNGVEISTKKSTDGHPLRFFRVWVDIEAPPKEILTRIVRERNVWDHQTINWRTVAILNAENCDVFQYVINDTPSHPTRDATVVRLWRTDMKELRGGCVLVERSVHSSETQLLGGISAAVLSSQFLVEPITGRSRVTYITRTDLRGRSNVWYSKVYGQLIARQLSQLRDSFKQFTRVDDGPETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZC9</accession>
    <name>A0A183GZC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lanthionine synthetase C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS589</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000205">
        <property type="protein sequence ID" value="VDO26329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZC9"/>
    <dbReference type="STRING" id="387005.A0A183GZC9"/>
    <dbReference type="WBParaSite" id="OFLC_0000058801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000058801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000058801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO26329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000058801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="801" mass="89409" checksum="0B188E3D2B5AF78D" modified="2016-09-07" version="1">MSSKWLPRYMENPFQNDPNKGAKSVTRAWLENEARQILKKIMNRSSSNDDLHGGAYTGGAGIAYAILRASSSSFNHNRDESMKYGSRLLMQHLEAIRKKESNRETYYLLGSLSVYVIYILYEKRSERSKQLINRVIEIGHIIANSDVHDDGVDELLAGRVGFLAAVITLRQHIAHEIIPDDCIRIVVNKIIASGRSYAVSKRFKVPLMYQYHGRHYLGTAHGLMGILQMLLCFIEFLDEGAKSDVLETVDWILSLQLKNGNIPSKVEEEGIDRGENELVHWCHGATGAVHLMIVAYLQTHNEKYLKSANAALNLIWQKGILMKGPGICHGAAGSGYAFLLFYRLTNVQVLFSILISVRSSVPNSRNDISLGVQDVFLMFTVSESKGDDKAMFSILHKRYFDNPYLADSEAGSGKVTKEILEKEAAILAEEIMTRKQNPDDYDGGAYVGVAGDGYSVLYASRLLSEKAKQYADFCSKVVEDQIKQIKKSGRRKDEGQYLLGALGVYVIKAILDYEVKKFVNTTIIDKVASLIDVICARDYLPNGADEMLVGRAGFLAAVLTLRMRLHHDIISDSHLKKVVDCIIDSGRSYAKRHGSRAPLMFRYYNVEYLGAAHGLMGILQMLLSFFDLLDGAALRDIESTLDWLLEIQAANGNFSPSVDEIGVNRGSNELVHWCHGATGAVHLMIVAYLCTKKVKFLEAAEKALDLIWRQGILRKGPGICHGVAGGGYAFLLYYRLTQKTKYLKYAQCFARIACDQNFRKNARIPDSPYSLFEGVGGLLCFLVDVSNPATAQFPLIPIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZM2</accession>
    <name>A0A183GZM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS682</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat EBI family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000250">
        <property type="protein sequence ID" value="VDO26695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZM2"/>
    <dbReference type="STRING" id="387005.A0A183GZM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000068101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000068101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000068101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO26695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000068101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35377" checksum="4FEB7BE10446FC58" modified="2016-09-07" version="1">MTFTSDDVNFIIYRYLHESGFVHTAYTFANESRVLESGAAGNDVPMGALINIIQKGIYYTEAEACAVASTSAADEPRTEKTMVENLSLLEAVLNDVPSYKIKEKQQNKLMLMNPTVKDDRQLQQSRDREMREVHGEKQNYSVSKSKELKVSPSTSTTLLPFGSMGQSSGGSGGNGSSSNSTIIGVPTTSASTLLSNNHQQFHPATSSITGQPTITFPHHGKQFFLDRERESRDRSQNGLMGKAKVAAAEFRAAQANNGDFNGTPMDIDGLKSRVNNGNGILSPAQLENRPYEISRDKVRYLKGHDSEVFICTWNPKNDLIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H0I8</accession>
    <name>A0A183H0I8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS998</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000415">
        <property type="protein sequence ID" value="VDO27836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H0I8"/>
    <dbReference type="STRING" id="387005.A0A183H0I8"/>
    <dbReference type="WBParaSite" id="OFLC_0000099701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000099701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000099701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000003">
        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015792">
        <property type="entry name" value="Kinesin_light_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01160">
        <property type="entry name" value="KINESIN_LIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO27836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000099701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60741" checksum="EDE8F3EE442376F1" modified="2016-09-07" version="1">MGFRSYRKKIEDIGRMTALSQEEILQNTRTVVQGLEALKDEHESIKGTLVSSIQGLNADESALIEEKTHIVDRNLEVLRLGIEEAQVMMALAGHLQTVEAEKQKLKAQVRRLCQENAWLRDELNSTQQKLQATGQQVAQLEEEKKHLEYMNSIKKYDDQQENDKSMDQSDSRSDNTLQDLGFGPEEDEEISGHMTGQFAHPTPAHSMAASASAGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNEALHIREKCLGESHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIRENVLGADHPDVAKQLNNLALLCQNQGKYDEVERYYKRALEIYEAKLGPDDPNVAKTKNNLSSAYLKQGKYKDAEILYKQILTRAHEREFGKVADDNKPIWQIAEDREESKHKGGDTSTYQEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGKYEAAETLEDAALRAKKQCLDAAHQAKIARLIAEHTTGLLSPHGGVEVCSNRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H126</accession>
    <name>A0A183H126_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1186</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000523">
        <property type="protein sequence ID" value="VDO28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H126"/>
    <dbReference type="STRING" id="387005.A0A183H126"/>
    <dbReference type="WBParaSite" id="OFLC_0000118501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000118501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000118501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="5">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000118501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="53697" checksum="CB081E0CA0DA23C0" modified="2016-09-07" version="1">MSLVGDVAEGCPGYQVSQSLSPLISPSSPDVYSNRGGGSPSPCTSPKRLSDSLILLHLPFNQHSKVEVKPGILARDAIAKILEKRAILPQMCRVCIGGDPSSPRIDLSMDLETLSNTLEKKELWVHSAYLSILVSIKHSFVRKTFLSVAFCDVCHKQIWLQGYRCELCQFTFHQKCGSKVPNYCDRMQQISHDVRMANKLRDICDQYEGPNAALVAEIIQHFQSLTADPLPNRMDISREHAVRLPGQPEISIGINESSRDRSSSAPNIYEITKDETLRETKMLDALSNNVHVLVQPSGTIRTTKPTSFSGLRDWQLTSNRRSNRLHPSTLVGMGSPSSTSSSPPPAYSGVTYDTNSGLPPTPPQSAPPQKTFGFRFRSKSPNDKIPIKGPGGRSSVSSDRLGESQEGDYKEKLKQRILMEGWEIDRSLVTYHKKIGSGSFGTVYLGSYFGKYVDQNSFIIFDLLSVTLFIVSDGYLLKVSIIITPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1J8</accession>
    <name>A0A183H1J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1358</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000621">
        <property type="protein sequence ID" value="VDO29230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1J8"/>
    <dbReference type="STRING" id="387005.A0A183H1J8"/>
    <dbReference type="WBParaSite" id="OFLC_0000135701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000135701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000135701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="68"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO29230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000135701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="828" mass="93117" checksum="3408997C4C885B5C" modified="2016-09-07" version="1">MTASFVGRLVNAIHLNAEPPKPNSLLAFVCKLASSHSNSSAVHGFVIGDEPIALFRSELERLQCILHFPEELAFQLSATEYQLFYEIQPMDYVHYVSCDLTSVPVADNPSPIRNLVKRLSEISSWITHLIISIPTSEERRTTLASIFRMIDSCWNIGNFNGAVEILMGLKSEKLRSFWLSLKPEEKKKYEQLCEALLPSNQAALSTAYREAIKRALRMPQCRLIPFFGVFLRDLYAIVNDMPSIVMIDDEDDKGRLEFMKEKSGGSRYASEIGVSGLLNADKINLVAVVLDNLELFYRHYKNISNFVVDPTGPSIGKKNPKFKGYNPVQPMKDVVRTATLVPLDTNHFDLDVIQRLHHGTTVIHCDPNTGRSTLCLLKLDASCGLLSWRKIGYLGTKEIEDRDASIPSMARMQSAKPLTMTPTENRNPPSSPCTRPVEAACTALDCGFLKLTYVKSIESVTSHDIDIESIHRRHSNEEMPVQMCCWTINFGCYLSDNEFLYFIAPEKSAQCWITGLTTIINYLLDQQKCADRRVLWLRKLYLQLCTNNYGQGSITDESLISSPQLYKTLQAFGGRVEGWTRLGLQSIVSQSLRPGMVRSAEVTATKSFKQMANAVTRRMKFISRSATQSQSPQSFASLKTRYLSARNRISARQCTISDPSIPKEILGSRESSLSSDTASLFSWYKSRRLSARALSTLWSGKIKKTKNSEDASPSSVVSEDFSMSSKSYGGEYLEKPVTLFEFIELYKLFSANMRTDLKDIFNDFLVMCGCGNASSIKHERNQKFSQIESSLSDIEFISNDILTRNTSTTAQQISEKQKKIYSALVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H280</accession>
    <name>A0A183H280_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS1590</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01000780">
        <property type="protein sequence ID" value="VDO30086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H280"/>
    <dbReference type="STRING" id="387005.A0A183H280"/>
    <dbReference type="WBParaSite" id="OFLC_0000158901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000158901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000158901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08307">
        <property type="entry name" value="Death_Pelle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037924">
        <property type="entry name" value="Pelle_death"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="194"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO30086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000158901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42648" checksum="29E06D10CB94BEA3" modified="2016-09-07" version="1">MDLSGVPSRTDTYVYLLPFSVRKQLAAILDPDNAWELLAFVMPDIGNVDVRACRDAGSYESPTENLLAIWGSKGNKIIQLYNCLGRAKLVRAMKEIRHLVDPLFYRWEEQCLQSANKNNRESEKALTFSSCCSPKSDGVLMRCFGETFSLKYFDNVRWLDPETDTFTDSDVIYKTLQNTPCIKYDDIMKITNNFSSNNILGSGGYGTVYRGTWEQTEVAVKRIQSTKEYGAKVTPSFIKNLTLFTLYEFPNQILQKEQMRQSLQELRTLSKYRHDNILPLYAYSLDGPQPCLLYQYMSNGSLFDCLFGKKSMVLTWLQRMSIMIGCARALHYLHSIAKNPIIHGDVKSANILLDKHLEPKLGDFGLCRDNFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Z8</accession>
    <name>A0A183H2Z8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS1861</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000968">
        <property type="protein sequence ID" value="VDO31036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Z8"/>
    <dbReference type="STRING" id="387005.A0A183H2Z8"/>
    <dbReference type="WBParaSite" id="OFLC_0000185701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000185701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000185701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000185701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="512" mass="59324" checksum="8A207EDF2E5FA623" modified="2016-09-07" version="1">MNVSEDEENAAQTKTTHSLTFDSIDIDDHIHCAFCFYTDCQYDRCTVRSCPECRAMLHGCKLEDHLLICAKAYVPCLCVGFGCPVLLRRDRMSQHLEHCCASAVCCAVQWNRRTLSNYAKRKLKRFAKGLEQWGIEPEMDDREIDVSAALIDQEAVIDSYRISRKDRKRLTDFQNPCHPLMPLRLSLEKLSRFEDEDSSDEENRQKELQLKFKRSPFENCYLCKSDPSSQHLHVLGNISCERNENATEKVIPPVKVSRLPTFYEIRHLYLNIGRERFSVFARKGENMPCIQKGISVYTFCCNESFRRDEYCTHYELSHMGADDCIGRCPMYIDGCPFYYCKAEPCWGELRYNRYLNCVVHRPPETLILPCDGSPLCDLPPIILIEILKYLDSASLRCLSSTCKHMRLICFKMASDCAMVHIKWERAESGNWSEKCFMWEFSKCQKPICEWKSASTTILSSHLSECKYNVPEKISHDRIAVLPTVKQAFSETIHPIGGQNQQRVKQIMQSIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3F9</accession>
    <name>A0A183H3F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS2019</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001084">
        <property type="protein sequence ID" value="VDO31599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3F9"/>
    <dbReference type="STRING" id="387005.A0A183H3F9"/>
    <dbReference type="WBParaSite" id="OFLC_0000201801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000201801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000201801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="496"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO31599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000201801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70933" checksum="BF85B854F53FC3B7" modified="2016-09-07" version="1">KRRNINYIHQYHQQPRQQVRVSGCVICSQQHNVENQTSRSYCFCGAYMDTRQHYFTNSYYLRNSVTSCVKQSFTHIPADHASITSVNSSSTIHSSCKNSYTPSTAESQLSSRSSSLANSKYTYQESEENKKSYNKKTVGVKKKQAVIGGKLPKRCNKQMKQTEKFKTMNTFQGKSLKKKKQLQQPQQLNNFSVDLESSNKNGPQSQLLPPPFKSDESARTMSSSVGPYHHHNDVFIYFGDDCFFINKEVSECTADAIFQKEEREEMTNQKSNSVFIPTSTQNLHLPTSYYIISEKKGAPTAYSNVNSQERKDPNSVALDKTSKEARDQNIPESCWICGKVGHLTSYCQSTPPAIWLLAKEMKKAQQKKKVEKLRDEKGRVLYTSDESSDDELVYGSDSDESVKQVAKNSSSLDYDIKLISDDDEEDELALTLKYKAYFAHINMEFGHKYAVARSDGDISYSLWPLFFVQIQSDECQRMLETHLDSLIANTPLSNTEMVIGTLCIAYCERFDAKFRAVITTICSNVVEVFYIDYGNYEWVEHKMLWSIADQDKTTTLQPGMAIPCILNAYDQEKITSRLLRSDVVKMKLAVSCGRWGFYLKFQKQRPDGIYVVEVDEGTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3V7</accession>
    <name>A0A183H3V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2167</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001188">
        <property type="protein sequence ID" value="VDO32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3V7"/>
    <dbReference type="STRING" id="387005.A0A183H3V7"/>
    <dbReference type="WBParaSite" id="OFLC_0000216601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000216601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000216601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000216601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49919" checksum="DFE72B1C85534428" modified="2016-09-07" version="1">MYIGVTHRGIYIYHISRMIHHITWNELDKVDYVGKEIMITPVSSYVSPYSSSFENAEHISNTLKSTSNLKNGFIKPYKTISVLKFHCPSAMFAKHLWRHILSQQAFFTENDAKHIKPKFSKPRIPLLTRGSTFRFPTSRVLHEIEVEGSGKRNGPQPKFTRYPLLRQAPRQHVCTTGNKYNSLPLRSGEKISEVIPENVEEENAVKIDSNNAVMNEINLLSTAETSTVVTSGSENTENTALLSDKLYRELCNHPKIHKCLAAFNDLLIENHYSNHDHLQLGISDSGMQSPRKDSFEEMLDAVKPLYTSTPTGNRNSDSHMTFATTTTTKIDDVGCDINRSFEKLKYDRSMPATNSQILTNEERLGTIARRPTTSIFTSAAKIFFSLLLFWLLLAAVAISLFEHDSPWLDSIPALDSVKHVLYEPLRHYILALYVRLGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H488</accession>
    <name>A0A183H488_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RBM39linker domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2298</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001290">
        <property type="protein sequence ID" value="VDO32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H488"/>
    <dbReference type="STRING" id="387005.A0A183H488"/>
    <dbReference type="WBParaSite" id="OFLC_0000229701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000229701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000229701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Splicing factor RBM39 linker" evidence="5">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000229701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22500" checksum="4BFBDC97B4F2E992" modified="2016-09-07" version="1">MQTSQFRHADDGKRAMEQMNGFELAGRPMKVCSVEGDELPPPVPQRTLDTDDADRRGIDLGTSGRLHLMAKLAEGSGLELPKSAKEILAQNQQQLESATATGPAIPPIATQCFMLSNMFDPSQETGVLHIFVDKASPNGNVYVKCPSVAAAFKSVNALHGRWFSGKVITANYVPVASYSQLFPDSVVAREPILSAVKPPTTATAMPGIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H641</accession>
    <name>A0A183H641_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2952</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001840">
        <property type="protein sequence ID" value="VDO34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H641"/>
    <dbReference type="WBParaSite" id="OFLC_0000295101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000295101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000295101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1758" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000295101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10942" checksum="40570BF69614A657" modified="2016-09-07" version="1">MVFNPLLSQRQGKALALFDVGSQISFISKKLVLNLKKTAEQETKIASFGMKKSKTCITIRTQLICKRQNANKRHFKHEFNTADKKKMKYSSFAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H644</accession>
    <name>A0A183H644_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS2958</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01001843">
        <property type="protein sequence ID" value="VDO34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H644"/>
    <dbReference type="STRING" id="387005.A0A183H644"/>
    <dbReference type="WBParaSite" id="OFLC_0000295401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000295401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000295401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="10">
        <location>
            <begin position="6"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="9">
        <location>
            <begin position="199"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000295401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52282" checksum="CA48B88A041C4EEC" modified="2016-09-07" version="1">MDCDIASYHVESFDYLAEQGIHLAALDVPAEKFRLPTGEAVELRYSGAQLGYPMIEVKQGSSLVDSIKLFPSECRQRGLTYRGPLKVGVEIRLNGAKVDYCEVIIGEVPIMLKSNRCHLRCLTREQLVARGEEGTEKGGYFICKGSEKVIRLLVANRRNYPIGIVRRSFREKGPLFTQYGMMIRCVRGNYSAAMMTLHYLESGTIVIALQYRRELFYLPFMYIIKALTSMNDQCIMEHMIKCRPGDHFWKGCVTAMLALCNDDGIVNQKTALTAIGKRFRVAIQDRVGPWEVAEDVGRFLLRVCVAIHLDSDDDKFFLLSYMAQKLIALTKGECAAESPDNPQFQEAAVSGHILLLIIRERLENTLNIARRKIEFEAKRKGENFVLSSHELIRAMGTQRSGEITRGLEYFLATGNLISKGGLTLQQNNGFSVIAERINQLRFVSHFRYFFRSHFADPKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6D7</accession>
    <name>A0A183H6D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3048</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001918">
        <property type="protein sequence ID" value="VDO35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6D7"/>
    <dbReference type="WBParaSite" id="OFLC_0000304701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000304701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000304701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000304701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16040" checksum="5B5B79DF7B16F074" modified="2016-09-07" version="1">MKLAEEVSMRNPAITKHELSLFDVNDSLCKITEREISSTELEKLLRACSTVREVYWLLQVLVRKIERSLNVTSANLVSWVHPNGTALYQSGVSLRKICDLAAEGKMTDESSILFRRFEPMLLSRIRNGTANVYDKVIILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H713</accession>
    <name>A0A183H713_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chondroitin proteoglycan 4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3275</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002142">
        <property type="protein sequence ID" value="VDO35929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H713"/>
    <dbReference type="WBParaSite" id="OFLC_0000327401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000327401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000327401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF3">
        <property type="entry name" value="DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552406" evidence="1">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO35929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000327401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24175" checksum="03AFE506AB29D4F8" modified="2016-09-07" version="1">MLGTGFVAIIWIVFIADRLVTGLIRRCNCEDDHECREKALNLVDKCSSDCGNNMAPLGGNIQDLVDCFGKQGPSVQAEDICLRRKIGYKCENQSQSTFINEINSDNLEKHFSFIFRFSDLTSCITCLQFMIDKSTKPTFGSFMQEIYDSLNAIVKYNYCIRSCGHELVDRETLTSFVKDCIGAHPMFYIEQMQACNCLLHKLHIMQVFGKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7A1</accession>
    <name>A0A183H7A1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS3363</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01002224">
        <property type="protein sequence ID" value="VDO36240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7A1"/>
    <dbReference type="STRING" id="387005.A0A183H7A1"/>
    <dbReference type="WBParaSite" id="OFLC_0000336201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000336201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000336201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO36240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000336201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20010" checksum="5B50D3C2CA362A28" modified="2016-09-07" version="1">MKNWRETLDDREDLKCLVDGPASSDTNQNEKCSIRSLCMHDMDIVKAICLESFPIQYPDCWFEEVLNGKLISFGITCEGALVAILVAELKILSQCNAEDRNLLSGNNSPLVYILSVAVRPPYRRHGFASRLLDHLMFMVVQRPPYPKAVYLHVLATNHGAINFYKKRGFCHHTTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7D2</accession>
    <name>A0A183H7D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRB2-associated-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3394</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002252">
        <property type="protein sequence ID" value="VDO36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7D2"/>
    <dbReference type="WBParaSite" id="OFLC_0000339301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000339301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000339301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000339301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="27768" checksum="78FDE236BD8BFCE4" modified="2016-09-07" version="1">MPSENTLERWFCEGQTFSGIVREGGQGSTDYSSVTLEENDELCGNQNQWNSSSPLHPPTAISNTYFYSATKIRPVSSNFNRSISSGTATNPGTNLTDYEPSNSSSVNPSQNSDSRLFHSNPVIFSEPSSYSAIVNQRTSKSVSTIPHPTIPPPPPPSLKLLSSVLRSPPTLPLLQSGEIRNDNSSLSLPLPPVGTKVGTTIAPGHLTFDIPDLPAIDSEDTENNSHINPEISHNTAANTANITDYLNNTDRNCLTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Q7</accession>
    <name>A0A183H7Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002370">
        <property type="protein sequence ID" value="VDO36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Q7"/>
    <dbReference type="WBParaSite" id="OFLC_0000351801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000351801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000351801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000351801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22443" checksum="6F7534D6B09F075D" modified="2016-09-07" version="1">MVDEVEAESMVTASANLKRVEETPDPLNCSFDKLPTLIGHNNFSILGMLQNCAVFYILGDNIKPHTNINLSKIEGSLNRCQSTKPLFYKRNNEYQLLIAQKMSIYTGQCVWQNNSDVYLSCLFDRKHWKKHSIKPSSSDDTEIIGHITDVDTHILHVFYIDGQYSFFIIHHKLHSNTFHKLNLTDDFYIIATMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H859</accession>
    <name>A0A183H859_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS3670</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002538">
        <property type="protein sequence ID" value="VDO37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H859"/>
    <dbReference type="STRING" id="387005.A0A183H859"/>
    <dbReference type="WBParaSite" id="OFLC_0000367001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000367001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000367001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000367001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42034" checksum="EE9D0857E1AA9A0D" modified="2016-09-07" version="1">MSSTQADQQTSKAGTGEAEKKEEQMEVEDEPLDEEILRMSADDLKSRTHLVENEIRIMRSEIQRISHAIDTLTSHVKENTERIKVNKTLPYLVSNVVELLLLEELQEDEGANVDLDAHKTKCAVIKTSTRATYFLPVVGLVDPSELKPGDLVGVNKDSYLVLEKLPAEYDSRVKAMEVDERPNEQYSDIGGCDKQIQELIEAVVLPMTHKDRFLNLGIHPPKGVLLYGPPGTGKTMMARAVAAQTKSTFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPAIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNDDIKVIAATNRVDVLDPALLRSGRLDRKIELPSPTEDARARIMQIHSRKMNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8D0</accession>
    <name>A0A183H8D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002606">
        <property type="protein sequence ID" value="VDO37618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8D0"/>
    <dbReference type="STRING" id="387005.A0A183H8D0"/>
    <dbReference type="WBParaSite" id="OFLC_0000374101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000374101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000374101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000374101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17361" checksum="DFD88EBCC4B1EA34" modified="2016-09-07" version="1">MFYRVLAKRLQHHERNRIRRIQTKLKKQAAARAAKTNESQSTLASATSGIEGSLPAGDIENYESDDSDKTLVSSGAASPNTSASNSGCLMEQNSYLQMSRVETPEPVLRNQEFMSKMMLDNTIQESGKCKMKSGMRRQLSAKRALTDRKEKKASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8P9</accession>
    <name>A0A183H8P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein muscleblind</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3861</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002729">
        <property type="protein sequence ID" value="VDO38009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8P9"/>
    <dbReference type="STRING" id="387005.A0A183H8P9"/>
    <dbReference type="WBParaSite" id="OFLC_0000386001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000386001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000386001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO38009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000386001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45188" checksum="A5503FD6460C6E20" modified="2016-09-07" version="1">MHAMSMFGNDQQETVAADGGFIPNNIIISDYDQTCQNSILNNVTVEGNKLNEAGNYQTVYSEYQPLIGNSVGMTTSAIPPASTPASYQQLNQMSPQPTAASASQFDHITVMTNLQQPSDVYSGIPVSSVSNGIAYTIPNSTNAAALQIYPPSAITQQVQQSVPALNAIPPMMQNRPDYNIQRLQTSRSSNSRTKTTYSPLLPVTGRSSNRQIANISVVSDDGPTVRQHLQQQQHRARLQQQLALQEKAKMDKDDLMTEYSGMLSSAVDKMLPVSTTINLPSSGPANMLVSAPMNIPATPSMNIPSSPSMNVLNSPSINIPSSPSTNVPVSPSMNIPPSPSMNISRVPQMPRQQYVPRSAPQKPRIMTDRARRMPIYDNHVYQTAPSYCTQKLRVTDIHEEAIQRAAAVYNQIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA24</accession>
    <name>A0A183HA24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4336</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003247">
        <property type="protein sequence ID" value="VDO39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA24"/>
    <dbReference type="STRING" id="387005.A0A183HA24"/>
    <dbReference type="WBParaSite" id="OFLC_0000433501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000433501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000433501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="174"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000433501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="51553" checksum="E06C3C8C43F56191" modified="2016-09-07" version="1">MDYVNARLDKDIFLEEEVCKLYMLRIEHLYYKYEIEDSLEHGQESSIALMERLCKEVYVRDDTKRLRQRAMLCQIYHLALHDKWHQARDLMLMSHLQAIVDHSDVSTQILYNRTICQLGLCAFRHSFIKEAHQGLSEIQNTQRAKELLAQGIAMRQQERTAEQEKLERARQIPYHMHINVELMECVYLICSMLLEIPHMASQEYELRRRLLSRSFHYQLKQSEKSSLIGPPENTREHVVAASRAMLNGDWKKCRDFIVNDKMDAKVWNLFRNSEKVKEMVIRRIQEESLRTYLLMYSTVYTTVSLETLSHLFELDKSTVHSVISKMIISEELSASLDEPTDCLIMHRVEPSRLQLLALHLTDKLTQLADSNEQILEPRAGRSYTGPGAWYGLRQERTIAEQQQRPNRMTYQDSSNKNRWNANLQNRRRMEQRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA27</accession>
    <name>A0A183HA27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003252">
        <property type="protein sequence ID" value="VDO39696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA27"/>
    <dbReference type="STRING" id="387005.A0A183HA27"/>
    <dbReference type="WBParaSite" id="OFLC_0000433801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000433801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000433801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000433801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7809" checksum="22104ACDBDCA6FE3" modified="2016-09-07" version="1">MGSVNPQFTALFAQLYEHRHTLCRLLLSSHKSAFASVLGQILSSPQGMTSAQQNQMNLFIQNFSTQNLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAN9</accession>
    <name>A0A183HAN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4551</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003503">
        <property type="protein sequence ID" value="VDO40307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAN9"/>
    <dbReference type="STRING" id="387005.A0A183HAN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000455001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000455001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000455001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000455001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24256" checksum="A8BDB71DC4989A50" modified="2016-09-07" version="1">TYVTFGGKSRNKSPQLVPGSFLLAGCKTSGSDAWVRLNGNFGRTNGSAITDNYNIFGNNGFDGYAAIAQVKNIWGTDGNDNQVSVPDLVPQGFPGNGIFSRKVFIGGLPPDVNADSISLFFEQFGANKIDWPHRKCTGGDTPPNGYAFVVFISDRSVEYLVSRCTYKQGKLNIVLKNGAKDVKVVQVRPWVLSDQVYRVIDELPLSDRYSVFIGGVPRTTTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAS2</accession>
    <name>A0A183HAS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Filamin/ABP280 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS4584</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01003550">
        <property type="protein sequence ID" value="VDO40410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAS2"/>
    <dbReference type="STRING" id="387005.A0A183HAS2"/>
    <dbReference type="WBParaSite" id="OFLC_0000458301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000458301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000458301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF16">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="113"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO40410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000458301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38530" checksum="18E9A259735CFFBF" modified="2016-09-07" version="1">MYVQIRLQDKEKKRIEESDFNFGKSKITSKHEIVRRGKDVDVKVDSLKLGKDDQLKVFVALAAKGGTEREEIEPKVKKSRHSYEISFRPTEVGTHKVMVYVNDTLHPMCPFPIRVYDASEIIVGEIAPQSTINDTVEFTVDAGRAGFGNLEMAIKDSDGIIIPSHVAQLETGTAKFLVTFNPTSTGMHTINITFNKEVLKNSPFEVNIVDEKPFDEMENVLVDGKKKDSRKEKEDKKREEKERMKKEKEEKLMAETLKKTKGKEVKKKKHQMERRTSVSKIPSLSRIGRPAQILITLAGEESLDITVIDPEKKKIESSMFDHEPGVKRVEFTPIQVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB86</accession>
    <name>A0A183HB86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4749</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003768">
        <property type="protein sequence ID" value="VDO40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB86"/>
    <dbReference type="WBParaSite" id="OFLC_0000474701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000474701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000474701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000474701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12314" checksum="892D4CCD2243AF0C" modified="2016-09-07" version="1">MSTINDNTSSFWVFVNHLYWLKGERLLKRAGVVERKGKVRGRRVPLFNCNFNSGREYVICRVLQPSQIAPAIIDSNPNIERKLFNSFLIDICHFFISKFADFWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC06</accession>
    <name>A0A183HC06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS5016</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Postsynaptic cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004105">
        <property type="protein sequence ID" value="VDO41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC06"/>
    <dbReference type="STRING" id="387005.A0A183HC06"/>
    <dbReference type="WBParaSite" id="OFLC_0000501701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000501701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000501701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000501701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17781" checksum="642F8EA4BB25F331" modified="2016-09-07" version="1">MVDLFRGYNSLIQPVRNLNETPIIVKIALQLALLINVDEKDQVMHTNVWLTLKWHDFQMRWNPVDYGEIQNIRVAPDKVWLPDIVLFNNADGNYEVSFMCNVVINYKGEMLWVPPAIYKSSCIIDVEFFPFDEQTCHLIFGSWTVGFYSMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC34</accession>
    <name>A0A183HC34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5045</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004138">
        <property type="protein sequence ID" value="VDO41874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC34"/>
    <dbReference type="STRING" id="387005.A0A183HC34"/>
    <dbReference type="WBParaSite" id="OFLC_0000504501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000504501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000504501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000504501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47460" checksum="F93739E599A1AE28" modified="2016-09-07" version="1">MSYLHSLNVLHRDLKAANVLIKEKVCDCLLNVEANTDEQLAHSLQARNGVCQKCGGSALNCLTLKIADLGLSKKLRVADCRMSVVGTVPYLAPEVIRDRKCSKAMDVWSFGLVLWEVLTGATPFEGLGPGAVQLQIGTFVKQKIPSSCPPDLRLIIESCWRDNPLERPTFKELIVELEKFGDKFRTTDPHDQTFLESSLNTLRKSMMEEISSIAREMARKAEELQKREENLKKGERELKLKTMIFELQQTLSERPPKEKPQPPKRRQHLKCEDISKPYDMKTEISLTKNMQMIESLNRDAGMGKALNGATLNGSTDQLSLVSKTKHVDDANLGFATLPRIPKKLTLKNENFDCVECYPIQQRVPSKSTPDLLKLYRLPVPYHNASPKLKRVNACKVKRDSTRTSGEEEVDERCVEVINDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC60</accession>
    <name>A0A183HC60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS5073</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004173">
        <property type="protein sequence ID" value="VDO41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC60"/>
    <dbReference type="STRING" id="387005.A0A183HC60"/>
    <dbReference type="WBParaSite" id="OFLC_0000507101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000507101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000507101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="166"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000507101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38690" checksum="7E814AB132A9EBE3" modified="2016-09-07" version="1">MEKLRLLDGLEEVPLLRIQSHCDTLFLYMQHLYNTSRFLDVIIQVGGSYATSAHRLILAAYSRHLGAALFNVQNSAVITLNIDPKVTGVEMDDLRTVIKYMYTGRCSNRSRSKTLSVANVLGCDSLVRLLESEEARIYPNVELENSNHAQELLQAIHRFKTQRKFIDCFMSIENRMILRCHRLMLCAFSTHFENALACTEKSAIVTVDIDPQITGVNSMALRNIVDFLYSGSIRKTSRHHKMLRQAAVTLGMARLVDTIDEELIASETHRSYYADEYDEALLTNTIYGLSDTISSRNFVENNESNISVVNCSNFEDEDDDSNQAETSAEDLMEEASNYIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HC78</accession>
    <name>A0A183HC78_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS5090</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01004197">
        <property type="protein sequence ID" value="VDO42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HC78"/>
    <dbReference type="STRING" id="387005.A0A183HC78"/>
    <dbReference type="WBParaSite" id="OFLC_0000508901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000508901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000508901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000508901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14266" checksum="5A519D21901BCA86" modified="2016-09-07" version="1">MGVARQQNVSLDCWDVFAQWVGLFGIARWFTCGVFVCDVRTASSGVCDGYRIFEMSWLWDWVSGMLNYLGLTKKNGKLVFLGLDNAGKTTLLHMLKDDRMAQHVPTLHPSKFFHVMVCIRISFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEA7</accession>
    <name>A0A183HEA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5817</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005210">
        <property type="protein sequence ID" value="VDO44444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEA7"/>
    <dbReference type="STRING" id="387005.A0A183HEA7"/>
    <dbReference type="WBParaSite" id="OFLC_0000581801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000581801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000581801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000581801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26483" checksum="6F1F0AAF80A09855" modified="2016-09-07" version="1">MDSKFKSIRFHIEISNLRDLFGLARHLSSVELYKSLSELCAAIFPTLLENGFINELSLDEIAYIEDAFRSYALENIVRTVDQFELSIQNLMIPKRTVRNIIMDILAVVKEPMDMKKLIDFCNSIKNDSHPKKRTKHMRSSVIIFSSADDVERIRNCESEKKFFPSEKDDVRNCGPQMELSTNEKGDNRCVQMPNIFSKATFKLVDIEKEYPSLSDIQIATATSEVCGKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HEI9</accession>
    <name>A0A183HEI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF2012 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS5900</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005327">
        <property type="protein sequence ID" value="VDO44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HEI9"/>
    <dbReference type="STRING" id="387005.A0A183HEI9"/>
    <dbReference type="WBParaSite" id="OFLC_0000590001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000590001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000590001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552496" evidence="7">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="51"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000590001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25168" checksum="13D1678D483FA107" modified="2016-09-07" version="1">MVLAMFPLLTLLLSMVRESAATLEETIEHATATYKIEGQIIFPELFDSQNGKLSPSRVLLNYNFKHVAFVRHDGSFVVSGVPPGSYIIQVSNIDYAFEPVRVDITSKGKIRARRLNLLQVSFYNIFFAPFQPSLVSSLPYPLRLNAVHQINYFRPREEWHLTDMLANPMVLMMVVPLVLLVILPKLVNANDPEVKKVNHLLKFINFFLLFKESIIVMTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HF57</accession>
    <name>A0A183HF57_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS6119</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005641">
        <property type="protein sequence ID" value="VDO45487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HF57"/>
    <dbReference type="STRING" id="387005.A0A183HF57"/>
    <dbReference type="WBParaSite" id="OFLC_0000611801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000611801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000611801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO45487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000611801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22205" checksum="EBA74F9460FC4DDB" modified="2016-09-07" version="1">MKEGDDLHKIANLINRLAEELGSTDILIQINAVEMFADGASQKASTAKYLLSIGIVDHLNRLFIQCMDQPDTGFLYPALIKFFGHLSVSNVECLPQFPKFLDSLFDLIYHFDRLDASLRLLAFDTLAAVGSTDRAKKFLDRQHNNCTQCDMRRAMNAFGVAIASGPLDLRVRHINALSMMLEVKNEAKVMMHLFIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFT6</accession>
    <name>A0A183HFT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS6349</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005987">
        <property type="protein sequence ID" value="VDO46282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFT6"/>
    <dbReference type="STRING" id="387005.A0A183HFT6"/>
    <dbReference type="WBParaSite" id="OFLC_0000634701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000634701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000634701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO46282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000634701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13781" checksum="2462DF618557A9A6" modified="2016-09-07" version="1">MDNIYEFGAKLLFSAVEWAKNIPFFNELSDTDQVHLFILLTLLRASWAELFVMNAAQFGMPVHVAPLLAASGLHSSPPLPTDQLVVFMDRIRVFQGQIERLKALQMDPAEFCSLKAVILFSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFX1</accession>
    <name>A0A183HFX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS6382</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006029">
        <property type="protein sequence ID" value="VDO46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFX1"/>
    <dbReference type="STRING" id="387005.A0A183HFX1"/>
    <dbReference type="WBParaSite" id="OFLC_0000638201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000638201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000638201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000638201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28279" checksum="FB16CBD82FEAA90C" modified="2016-09-07" version="1">MDHQSSEMPSLPPQTVPVIPTPSPAIPPPQGTVYFRPPYVFPDGLPEPVSCEQPNVPSLLENNSTEDFTNNNAGLVQEATPEVSPNAIFCPPLPIPFPFPPPVQSIPFFTPNISPIPVICVLPPFPCISIPGNALPFSSYQNWLMANAAPQNPTMRRTPRKNNIFSTGAYQSSIRFCGNDDCRNFQRDNAIRSELMHQIRSGPSLSNYRTRLCINFKNGHCPYGDRCQFIHQQTSDGIMKTRFSVNAPEFVPGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGB0</accession>
    <name>A0A183HGB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006238">
        <property type="protein sequence ID" value="VDO46802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGB0"/>
    <dbReference type="STRING" id="387005.A0A183HGB0"/>
    <dbReference type="WBParaSite" id="OFLC_0000652101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000652101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000652101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14288">
        <property type="entry name" value="UBA_HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041918">
        <property type="entry name" value="UBA_HUWE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000652101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37722" checksum="304CA943F888B792" modified="2016-09-07" version="1">MTRTRRIQENEGGTPCENAVQLALQIMKGFQQALEWKPYDKTDPAIMLPYLAIWINNLSNILYDERKSPYHLMLSAFYRTGTHDTFFNIISNYFGSDQDQNYCVEMGQLLQAWLSLTERLVNAHAFRHSRYKMSERFAEAKRFPTEKYLTKCQQDAFRQANVVFSMLSSLPLSEAVNFNICDMIVSIYREIVKGIVPLTEKQRQAVTTTSEDRKKMEAELDGASIDLLVDMGFDRDAAVDALLEYSTVPEAAEYLIATDGLGRLRQSSTDERIDADEIDAEEGSGSQNNDLNVEFEDVLLKEPISLNEVPPLDTRLVLTSLCKDVGYDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGD7</accession>
    <name>A0A183HGD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS6546</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006289">
        <property type="protein sequence ID" value="VDO46898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGD7"/>
    <dbReference type="WBParaSite" id="OFLC_0000654801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000654801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000654801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO46898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000654801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11490" checksum="5035B700ABDE406B" modified="2016-09-07" version="1">MGELSNGGGMMMMNEDCISEDGTHSLLVQQRNGSPIQSCSGNEDEQMDEEETTTKRSFKGRSGQDTKNNQNQDLLKQQVSDLAIQMTYLSHQVISLFNYFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HGH2</accession>
    <name>A0A183HGH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6583</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006341">
        <property type="protein sequence ID" value="VDO47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HGH2"/>
    <dbReference type="WBParaSite" id="OFLC_0000658301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000658301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000658301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000658301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32381" checksum="441510B1D09B0403" modified="2016-09-07" version="1">MVIDELDEALMQIGDASGSEQHAEYVDRMHEQGKQGNTVQQDVGLHMSVSEEVIVETEESHPAMSPTPGSDVGDMEECINDEEGLYSDDEDHSDMFADREVDQVIRDPVTGEISLTMDLEDLVSRTITFDNGERIILCFSKRCRPQIAWNGHLYVAASDLSEVSYTKWRCVNEGCPGALRTSPGLTELRSSGHHHLTTCKPDDLRVRLRIVIYDLRLMAEFTDDPLEDLYSHFVEKLAAENPDVLALFPPLDTLVKRLTKHREYKVRIFFIFSELLLQNNFYDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHU0</accession>
    <name>A0A183HHU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS7053</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLF family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007108">
        <property type="protein sequence ID" value="VDO49091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHU0"/>
    <dbReference type="STRING" id="387005.A0A183HHU0"/>
    <dbReference type="WBParaSite" id="OFLC_0000705101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000705101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000705101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019376">
        <property type="entry name" value="Myeloid_leukemia_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13105">
        <property type="entry name" value="MYELOID LEUKEMIA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10248">
        <property type="entry name" value="Mlf1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO49091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000705101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20011" checksum="6D8DD3AAAE42FDAB" modified="2016-09-07" version="1">IFRHAIRTGEDGVGDKLTIGHTIGDRTHVIEKKRDRDGRIRERQSFVNLTQDEAEAFDREFASRARRNLMDGRTDGQRNRAIEGGNRYGGTSSSSRSHAPRIDGTGTNAPIITLPDEEDDSDVMIEEDYDRGRRSSARFGSASSGPVIREVTDDDEDGGNNHKRRKGFFGRLFKENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIX6</accession>
    <name>A0A183HIX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7435</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007769">
        <property type="protein sequence ID" value="VDO50996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIX6"/>
    <dbReference type="WBParaSite" id="OFLC_0000743701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000743701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000743701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO50996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000743701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17110" checksum="B9A81A5AD040DBA0" modified="2016-09-07" version="1">MASPKLISLLLLFTIDGLILSGVGHYYSNLGGKQSLMLTPNKWNYNIYSKLPITFSEMRLSGQYFTTFVTTIILIITIISHIMQLYWCKYSRLLFLNFSVIKLKFWVKRLHDHFLDDLDDQEWKRYTFAKHSLTFKEYNNETCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJA3</accession>
    <name>A0A183HJA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007992">
        <property type="protein sequence ID" value="VDO51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJA3"/>
    <dbReference type="STRING" id="387005.A0A183HJA3"/>
    <dbReference type="WBParaSite" id="OFLC_0000756401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000756401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000756401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000756401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7274" checksum="95CB503DA773C8FD" modified="2016-09-07" version="1">MNKYKADRNRTIDSRFDKYMLPRKQCNDFLRGVVYTDDIYEKPSIFRKPQRLEALSVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKL4</accession>
    <name>A0A183HKL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RNase_PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS8026</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008784">
        <property type="protein sequence ID" value="VDO53707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKL4"/>
    <dbReference type="STRING" id="387005.A0A183HKL4"/>
    <dbReference type="WBParaSite" id="OFLC_0000802501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000802501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000802501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO53707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000802501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="27678" checksum="18BCF8508F0C3041" modified="2016-09-07" version="1">MQHSSVRPVPLNNLLKRTENDKAGTSFGSTSNTFRSIVMQTGALHDQKGTVYVEFGSTKVICAVDGPKEITKNTDADPTEGQICVFLKNVSMESTAVPGSSSISNKENSGMRNAVESALRSIICLELFCKAQIDVEITVLNDDGGVLAASLIAASLALIDSGIQVYDVCVAAHIVMLADGRIIVDPSTSSFPFSSVTDSEEFPGNAHLSVTVGMLPSLNQLACCEFVGIAEPQQLRHAIAVAVENSLKLYPLVRKTLMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLE6</accession>
    <name>A0A183HLE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS8308</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01009280">
        <property type="protein sequence ID" value="VDO55051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLE6"/>
    <dbReference type="STRING" id="387005.A0A183HLE6"/>
    <dbReference type="WBParaSite" id="OFLC_0000830701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000830701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000830701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO55051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000830701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17796" checksum="5896D91D2CE3A25E" modified="2016-09-07" version="1">MNEKKKNDNKDENQEEMAVDNDKENGNSENSSDVVDEDSDDEKEDDKDEDDEDEEYVVEKILDKRYNRRKKRIEYLIKWAGYDNENENTWESAENCVSSSIFIHLFLSLLAHLLLEITSFIIYVKLICIPPIIDNISTCWKDSLYLLKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMD8</accession>
    <name>A0A183HMD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8650</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009959">
        <property type="protein sequence ID" value="VDO56721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMD8"/>
    <dbReference type="STRING" id="387005.A0A183HMD8"/>
    <dbReference type="WBParaSite" id="OFLC_0000864901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000864901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000864901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO56721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000864901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14691" checksum="D4518A3A464E9A84" modified="2016-09-07" version="1">MTRKVPLSNRKHLEQKNVSKSNSCVSESKNFMLNGPDNIIPEIIKKTGRKVPLRHLDLISNNSNEKNQENKHRVITSCLKQPNKSLDEQTYHCSNCPSFFTSRRGMANHYKLHGANKRYKCTSCDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMD9</accession>
    <name>A0A183HMD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8654</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009965">
        <property type="protein sequence ID" value="VDO56749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMD9"/>
    <dbReference type="STRING" id="387005.A0A183HMD9"/>
    <dbReference type="WBParaSite" id="OFLC_0000865001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000865001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000865001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000865001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6188" checksum="DE0D3E895A7A5970" modified="2016-09-07" version="1">MPESLTSSYLGGAGDMMRREDVAAPLHFYTHPLQVSVACRYNFMQISKSFPSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMM6</accession>
    <name>A0A183HMM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8737</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010116">
        <property type="protein sequence ID" value="VDO57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMM6"/>
    <dbReference type="STRING" id="387005.A0A183HMM6"/>
    <dbReference type="WBParaSite" id="OFLC_0000873701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000873701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000873701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000873701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13068" checksum="B5A0F6EEB520D11F" modified="2016-09-07" version="1">MAPETLSKKPKFTTKSDVYAFGILIYEVYSCGGEPWPEVAMVQDIIPLVRKGRIMATPSLLNDKNVKEIMHQCWKRKAVERPDFIEIVKRFRTILQSQKVPIIFWSLIGSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMQ3</accession>
    <name>A0A183HMQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IHABP4_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8767</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010179">
        <property type="protein sequence ID" value="VDO57302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMQ3"/>
    <dbReference type="STRING" id="387005.A0A183HMQ3"/>
    <dbReference type="WBParaSite" id="OFLC_0000876401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000876401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000876401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO57302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000876401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15518" checksum="D53AB36390D4EEEC" modified="2016-09-07" version="1">MVEYGVNVTNKFGFLSDDEVDDPEMIFRKAEALSKKEEKSASQKKADKNAAARKKKEIISATVMTAVARETEAKKPQLPVGGGMKKNDFSKENKENRPDGERSRGRGRGRGGIGRGRGFIQQSDNTRPALDQVIYFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HN76</accession>
    <name>A0A183HN76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OB_NTP_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8943</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010525">
        <property type="protein sequence ID" value="VDO58129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HN76"/>
    <dbReference type="STRING" id="387005.A0A183HN76"/>
    <dbReference type="WBParaSite" id="OFLC_0000893701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000893701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000893701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552582" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000893701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13581" checksum="798844FA51DFF544" modified="2016-09-07" version="1">FSFFFFLFSIVFIVSDNPKRIFVADFSVTINADLIKFGELQAHRRIIGFIGVIQAPVEDEKAELPQQFSDVDITGDHRASISNPRSYFANIKEQYDSVKTEYESTIVDSRCIVIGYSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HP15</accession>
    <name>A0A183HP15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9227</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011103">
        <property type="protein sequence ID" value="VDO59261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HP15"/>
    <dbReference type="STRING" id="387005.A0A183HP15"/>
    <dbReference type="WBParaSite" id="OFLC_0000922601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000922601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000922601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF172">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO59261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000922601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="9011" checksum="06F45FD11E75F083" modified="2016-09-07" version="1">MKASFSSLFRLLKIFGKKFSITKKELRKWHKDFLNDYPSGEMKLDEFQNIYKQFFPKGNPTKFATFVFNVFDKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPF7</accession>
    <name>A0A183HPF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9372</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011420">
        <property type="protein sequence ID" value="VDO60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPF7"/>
    <dbReference type="WBParaSite" id="OFLC_0000936801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000936801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000936801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000936801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11944" checksum="D29DA220BAB207C4" modified="2016-09-07" version="1">MLRKKGAGDCILKVWFRIYMNYEMNSSNPPLMKLNLVKKRTVITQDRKQANVGTNNHTSHPFSSLLPYPLDLIEVVVVTIIIAALVAVVVVVLIVAVAVAVLLVANFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPM0</accession>
    <name>A0A183HPM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoporin NDC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS9431</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011540">
        <property type="protein sequence ID" value="VDO60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPM0"/>
    <dbReference type="STRING" id="387005.A0A183HPM0"/>
    <dbReference type="WBParaSite" id="OFLC_0000943101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000943101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000943101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO60522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000943101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21415" checksum="1D30B69B38011FCA" modified="2016-09-07" version="1">MFSGWSVSFFFIYVLWKNLASLILLYQKFVAAYFATVILISFAVCYRYGPPTDIRSYNLAQWTLQLIALVLIYFSCQITDISIGVIALLLLWAVSKNWLINIATKFMSIFNVVWHFLFPQYQRLLTMEEYQKQGEEETRKALEELRQYCRSPKADVWKITSSVSDPKRSVNFCCNLMIFLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPM1</accession>
    <name>A0A183HPM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9432</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011546">
        <property type="protein sequence ID" value="VDO60537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPM1"/>
    <dbReference type="STRING" id="387005.A0A183HPM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000943201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000943201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000943201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO60537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000943201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13008" checksum="18DD90DC063114ED" modified="2016-09-07" version="1">MNGKLYDAGKFASSLRKTLMMEHLGLLPEQKRKPPKREIDLDDPVADSFFFDTWVAIAKKNTEIFEQVFNVIPTDKLKDFEDVQMYIAKLPLSETMPQVAEEYLRGLIGNLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HPU3</accession>
    <name>A0A183HPU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9507</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01011715">
        <property type="protein sequence ID" value="VDO61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HPU3"/>
    <dbReference type="STRING" id="387005.A0A183HPU3"/>
    <dbReference type="WBParaSite" id="OFLC_0000950401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000950401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000950401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="89"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000950401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24170" checksum="0B1DD6B0ED0DD404" modified="2016-09-07" version="1">MANETIEISALKVNQQQNQKSSTVQEIERLQRNREERRAQQQEAKKQKEQMKSIDPGNPNWQFLTMIRDYQSQIDFRPLKISDQVNDNRICVCVRKRPLNRKEIMKKEIEVITIPNRDHLIVHQPQVKVDLTKYLENQKFRFDYTFDENTSNEMVYKFTAQPLVRTIFEQGFATCFAYGQTGSGKTHTMGGDFTGKTQVSKKFSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQG0</accession>
    <name>A0A183HQG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS9725</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012247">
        <property type="protein sequence ID" value="VDO62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQG0"/>
    <dbReference type="STRING" id="387005.A0A183HQG0"/>
    <dbReference type="WBParaSite" id="OFLC_0000972101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000972101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000972101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO62815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000972101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12640" checksum="4FE5C6860A70B785" modified="2016-09-07" version="1">INFLVFNHISAVVYFCHILPVILDYFHPANIQFLRFKQENLSTMNNTSSLMGSQGTSGSCAGAIRALTLELKGLQTSPVEGFTVTANEDNMFVWTVALYGPPGTLYQVNNFNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HR21</accession>
    <name>A0A183HR21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9931</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012711">
        <property type="protein sequence ID" value="VDO64530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HR21"/>
    <dbReference type="STRING" id="387005.A0A183HR21"/>
    <dbReference type="WBParaSite" id="OFLC_0000993201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000993201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000993201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000993201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="6514" checksum="DFC66B1BB9F82733" modified="2016-09-07" version="1">MHFEMTIDGQLIPLLKPCDKEKFLQRAEPYLGSDMFHVMIADRLMMFIWKIIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS94</accession>
    <name>A0A183HS94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS10353</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013711">
        <property type="protein sequence ID" value="VDO67819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS94"/>
    <dbReference type="STRING" id="387005.A0A183HS94"/>
    <dbReference type="WBParaSite" id="OFLC_0001035501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001035501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001035501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO67819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001035501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7634" checksum="EF732272D674BB05" modified="2016-09-07" version="1">MLQSLAIPGSIFLTVLSGYLFPFPIALFLVCTCSACGAQICYFFSFLFGRERIMAFAPEKISKWKNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HSD8</accession>
    <name>A0A183HSD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0020 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS10396</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01013818">
        <property type="protein sequence ID" value="VDO68154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HSD8"/>
    <dbReference type="STRING" id="387005.A0A183HSD8"/>
    <dbReference type="WBParaSite" id="OFLC_0001039901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001039901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001039901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO68154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001039901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21867" checksum="E0BCE3613D66C08E" modified="2016-09-07" version="1">HPYRYCLLIIVFQRHVYVFEFPSLNDVILILSRSVLVKFAIEWMANCNDYDELCATIGEKEHDIKNYDSTEQSFAIRIRSIGKKNNRIPPRTIITDIGKALNFKKSPVDLSNPCNVFYVIEEYDLNLLQKLYFGKLIGCGQGHLKNHYCLAERCYIGNTTIDPELSFLQANIAKVDVGSLVLDPFCGTGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT32</accession>
    <name>A0A183HT32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014404">
        <property type="protein sequence ID" value="VDO70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT32"/>
    <dbReference type="STRING" id="387005.A0A183HT32"/>
    <dbReference type="WBParaSite" id="OFLC_0001064401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001064401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001064401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001064401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7938" checksum="CD07B082BBAF0486" modified="2016-09-07" version="1">MAYQISRPNDDTDRTLWMGDLSPDWDQTFIADAFARMGEEVTNVKIVFDKQNGKVVFIYYLQIAISSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT53</accession>
    <name>A0A183HT53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10664</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014449">
        <property type="protein sequence ID" value="VDO70380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT53"/>
    <dbReference type="STRING" id="387005.A0A183HT53"/>
    <dbReference type="WBParaSite" id="OFLC_0001066501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001066501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001066501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001066501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8591" checksum="5C325CCF5A00E625" modified="2016-09-07" version="1">MDKRVNSMIRRQNRLRDDLRDAKRLLGVADEHFLTASTSNLQGATLLEALTQETKILEKRLIACRNHAMIVTCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT79</accession>
    <name>A0A183HT79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS10697</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014537">
        <property type="protein sequence ID" value="VDO70557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT79"/>
    <dbReference type="STRING" id="387005.A0A183HT79"/>
    <dbReference type="WBParaSite" id="OFLC_0001069101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001069101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001069101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO70557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001069101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17252" checksum="F460754A259517E2" modified="2016-09-07" version="1">MALPWECFMMRTPITLTLFLNAASIPTIVIERVIATYFSSRYEKFGKSIAVILVIAQSATGIGSFLFIASDFELFDSEKTVYCSTANDGNATKSAVITGFYMTIDFISVLTFPILFFINKAILIHYFLISSCKSSIDSLINGWIDASASFSKSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU32</accession>
    <name>A0A183HU32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015301">
        <property type="protein sequence ID" value="VDO72932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU32"/>
    <dbReference type="STRING" id="387005.A0A183HU32"/>
    <dbReference type="WBParaSite" id="OFLC_0001099401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001099401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001099401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO72932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001099401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12951" checksum="CF1D771A37A26429" modified="2016-09-07" version="1">MGLIIANLLANGFKEILELSKKQAENEEMVSEAKQRSALFIDFEEEWKNKETAYIQEIQELKLAVGKTETDKIEEMKRDISFLNSIIAEQYKKEKDLKEQIAILNSLPANEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV68</accession>
    <name>A0A183HV68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11378</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016373">
        <property type="protein sequence ID" value="VDO75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV68"/>
    <dbReference type="STRING" id="387005.A0A183HV68"/>
    <dbReference type="WBParaSite" id="OFLC_0001138001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001138001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001138001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001138001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16303" checksum="815D27AA2396EDFF" modified="2016-09-07" version="1">MEPSASLIQHLSPSQQQQQQTPVDAWDDEVDEKVEMIETKEEMVIKEAVKDDSPPVEEVQEPVKPTGLETMKPENIVGKANNISATKETADEDTTLPVKFKQAVYIDDNNRKEHVNMVFIGHVDAGKSTIGGHLMYLTGMVDKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVB6</accession>
    <name>A0A183HVB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MIF4G_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS11425</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016482">
        <property type="protein sequence ID" value="VDO76344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVB6"/>
    <dbReference type="STRING" id="387005.A0A183HVB6"/>
    <dbReference type="WBParaSite" id="OFLC_0001142801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001142801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001142801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO76344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001142801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="21133" checksum="D7844315FFF2E12D" modified="2016-09-07" version="1">MILETIFSQLFRLPHPPLRPLFYGSLMIELCKIKNMPQVIAQAAELFYQRIDTMQLECIDRLIDWFSYHMSNFEYRWSWIDWDDCLDLNDYAPRRYFVKEVIEKCMRFSYHERICDCLPSSFEEITPEKPSILFLVNQGLLFNYLYIYIYIYLFLFGIYLKLKLTLFCFNKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX92</accession>
    <name>A0A183HX92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">OFLC_LOCUS12103</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01018347">
        <property type="protein sequence ID" value="VDO81939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX92"/>
    <dbReference type="STRING" id="387005.A0A183HX92"/>
    <dbReference type="WBParaSite" id="OFLC_0001210401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001210401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001210401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF93">
        <property type="entry name" value="CARBOXYPEPTIDASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552661" evidence="3">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDO81939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001210401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17058" checksum="27EDD1CAC1DD2E6E" modified="2016-09-07" version="1">MNNQKLKILALNLWIIKMKLASRSNSRMCMLFSGGITNGAKWYSISGGMQDFNYLATNAFEITLELSCEKFPDGSLLPKLWEDNKEALIDFIKKIHIGIKGTVMNKITGEPISNAVIWIKNSTDITPIKHPVTSCKFKHQNDEFRANLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXK1</accession>
    <name>A0A183HXK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12215</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018675">
        <property type="protein sequence ID" value="VDO82886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXK1"/>
    <dbReference type="WBParaSite" id="OFLC_0001221401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001221401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001221401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001221401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11751" checksum="A790CDD5F0112F5A" modified="2016-09-07" version="1">MEASAISRTIILVCVHMRLLNSCNMVIVYLYRQGDLRHFVIRWFKDQFRGRKSHTDRESVGCLFNNFSNLYIEVYFPLFTQSVHFNFEFLADLTIKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXZ9</accession>
    <name>A0A183HXZ9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS12361</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UZAJ01039830">
        <property type="protein sequence ID" value="VDP11157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXZ9"/>
    <dbReference type="STRING" id="387005.A0A183HXZ9"/>
    <dbReference type="WBParaSite" id="OFLC_0001236201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001236201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001236201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP11157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001236201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35786" checksum="1635CDD0C02437E3" modified="2016-09-07" version="1">MGKIKLKKKDAPKRTNIMQALPFNTDRGQHILKNPGIVNAIIEKSSIKATDIIFEVGSGTGNLTIALMERAKKVIACEIDRRMIAELKKRVIGTSHQQKLEVKQGDVIKIEWPFFDVCIANLPYQISSPFVFKLLLQRPLPRYAVLMFQKEFADRLLAKPGDKLYCRLSVNVQFLAQISISFVEHLMKVKRTEFRPPPKVDSAVVRIAPRNPPPQINFQEWDNLLRIVFLRKNKTLLSLFKNNQVCDSLEKSYKVLCSIKNKEIQSQFNMKEKVEDIIAKSGFASKRARQMDTEDFLSLLLVFNKEDVHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYQ0</accession>
    <name>A0A183HYQ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SFR19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS12612</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039882">
        <property type="protein sequence ID" value="VDP11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYQ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001261301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001261301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001261301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057031">
        <property type="entry name" value="SFR19-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23030">
        <property type="entry name" value="SCAF11-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SFR19-like C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001261301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12637" checksum="AD1C450BA9ADF943" modified="2016-09-07" version="1">MDNVVLCDDSKIGESGRKSASADDEETGEAIKVKKFHKNGAMFEEARRMLSSSLKKVYRLKQITKQEYKEIMKKGVTALSQRTKLDQRKVDEYAAKYVECVVHRRKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYZ0</accession>
    <name>A0A183HYZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12702</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039909">
        <property type="protein sequence ID" value="VDP11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYZ0"/>
    <dbReference type="WBParaSite" id="OFLC_0001270301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001270301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001270301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001270301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12785" checksum="18D7A21331B13533" modified="2016-09-07" version="1">MILRFCYSGSALNRLEAPTVLKWMDVLESMDCYYCDHGLECGNIQRKMKSQQKFGDINSQLVLGQKYMWHMIKACFTDEENISAEIRKGLKSGFSRFILGISFIAGVVVFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZ83</accession>
    <name>A0A183HZ83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12795</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039935">
        <property type="protein sequence ID" value="VDP12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183HZ83"/>
    <dbReference type="WBParaSite" id="OFLC_0001279601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001279601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001279601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001279601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24000" checksum="BA606CCF15AA358B" modified="2016-09-07" version="1">MALTEKNVRIFLSPKIKVAASGQTKITDFASSTLKGTYGDGRAFIAHFKKPARVVANIPYRATVTFKEEVETFAGGNGQEDILVYVGSGGVVEQNCTATTPAVDQSSVAVFAFHNDDPNGIRRGMTRGPAVYTDAIGGFYNRPTNNVAPVYSEGCLYEGQIPEIHFMAPMEVKKEVSDVMERKILNFHACXXXXLDWGIIDVFSRRKILNFHACFFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HZI2</accession>
    <name>A0A183HZI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12894</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039967">
        <property type="protein sequence ID" value="VDP12419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HZI2"/>
    <dbReference type="STRING" id="387005.A0A183HZI2"/>
    <dbReference type="WBParaSite" id="OFLC_0001289501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001289501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001289501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP12419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001289501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13320" checksum="B824C6D23EFD3835" modified="2016-09-07" version="1">MSMCWPGFDPVGSYGATSNYSHQPGTCPTLSMTIAKQNDQQIAHQFHPCNFVTFAQHFSTLSFNTNNTPSLLWPSTSTKKKPTPVPENLKDEVNTFHKKVCLILHLLIYNTTLPYQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0Q0</accession>
    <name>A0A183I0Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4819 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13312</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040139">
        <property type="protein sequence ID" value="VDP13426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0Q0"/>
    <dbReference type="STRING" id="387005.A0A183I0Q0"/>
    <dbReference type="WBParaSite" id="OFLC_0001331301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001331301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001331301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032147">
        <property type="entry name" value="Cic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16090">
        <property type="entry name" value="DUF4819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein capicua homolog-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP13426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001331301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38520" checksum="C9EC848920A42FDB" modified="2016-09-07" version="1">MSIEFRLFPDFLYFIRLVSVESMNETTVNLEVWKASRVLARPPDIDGYLPACIKGVRANKDVTVQFDNGTEHVFEDVITSLREYPDILADQAPSPDSINVADVVCVKWKNDENIYRLAEVLKKTAWPIMFQMRLHVGLSTDFWFHRASIRLLRPPWYDELNAMGSYNSSAIKSRDENGGTYSNSCSRVLASAITHFAPLTLPVAVQTTSSSHLRHFLFSFSIKKDTIIYFGATENESQTLQKKASYSDTADSDDEQIKDDQIDGTSDANNFSGESTPRSAVGTTATERMSAQFFGLTPAQTISGSATTFDEVQQVQQCVASQAVSAVCAAAVQVKILTSVVMKYTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I164</accession>
    <name>A0A183I164_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2156 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13476</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040220">
        <property type="protein sequence ID" value="VDP13862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I164"/>
    <dbReference type="STRING" id="387005.A0A183I164"/>
    <dbReference type="WBParaSite" id="OFLC_0001347701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001347701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001347701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP13862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001347701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11012" checksum="3D0C4C1659460A69" modified="2016-09-07" version="1">MKSPIFLLAPIMKNEIIGAEKIRIDDIPDLFNTVFYLARCWRAYGGDLDRIKRYMKDLFDHRRMLACDCIGRQSQFSIKLSFLHLKDSVKSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I1C3</accession>
    <name>A0A183I1C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor 3B subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS13535</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040253">
        <property type="protein sequence ID" value="VDP14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I1C3"/>
    <dbReference type="STRING" id="387005.A0A183I1C3"/>
    <dbReference type="WBParaSite" id="OFLC_0001353601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001353601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001353601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000141">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001353601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28599" checksum="056889C882061617" modified="2016-09-07" version="1">MSAGPILERNQDATIYVGGLDEKVTDGILWELFVQAGPVVSVNMPKDRVTSSHQGFGFIEFMGEEDADYAIKIMNMIKLYGKPIKVNKASAHEKNMDVGANVFVGNLDPEVDEKLLFDTFSAFGVILQVPKIMRDAETGNSKGFAFVNFASFEASDSAIEAMNGQIIVHESKFSAPLPMWGMPPPPPITPGIRPPTTPTPTPPPPPPPRGFPRIPPPFPPMQGRASFPPPPPPSVRMMRPPPPPVIRPTRPPPPPTSAPAPPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I221</accession>
    <name>A0A183I221_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS13783</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040392">
        <property type="protein sequence ID" value="VDP14641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I221"/>
    <dbReference type="STRING" id="387005.A0A183I221"/>
    <dbReference type="WBParaSite" id="OFLC_0001378401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001378401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001378401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP14641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001378401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42730" checksum="C5DB5C87114E0294" modified="2016-09-07" version="1">MFIDVLEWGIISRGIKIFEMTLYLLNQWKNQPGGAQDASAFLLALKSEHSSMREKELIIEVLDDWDVLTPTWFEVADYLSVIEGLHENENFKQRYLAALLASKVAFCLGDYNGALQLALAAEDKFQLTPRSPSILVGSQDEQYVNKIIEHALDTYKQAKRNEEEIDPRLEKLINRLFERNMKKRELRYVIGLALDTRRTDMILVAIKATDDQATLLTETVAKVLESQMDRTFRSIVLDLLLRLFSELEEPDFVSMCQCLIKLEKPDDVADILQRLVSNKGDNGVLLAYQIAFDLYENASQQFINKIEQSLIDNAPTEIPSTSGVVIHPMEITTEGKTESQILSDDTAIANEEEEERKNNEQSKNTSSSKSLEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I256</accession>
    <name>A0A183I256_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS13818</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040412">
        <property type="protein sequence ID" value="VDP14740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I256"/>
    <dbReference type="STRING" id="387005.A0A183I256"/>
    <dbReference type="WBParaSite" id="OFLC_0001381901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001381901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001381901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDP14740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001381901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21157" checksum="57D7F6D4296BE428" modified="2016-09-07" version="1">GNRSEVVIVEYFTTVGTQLYFTRLCHQKVACFQIFFLVTSYGTVYLMFFKFRATYDRSHDTFRIEFLIIPAIALAFLINHHFSFMEIAWSFSLYLEAVAIMPQLFMLSRTGSAETITAHYLFALGAYRALYVLNWIYRYYTVGYLDPIPAVAGVLQTVLYADFFYLYVTRVIRGRGNLELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2C4</accession>
    <name>A0A183I2C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS13886</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040449">
        <property type="protein sequence ID" value="VDP14896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I2C4"/>
    <dbReference type="WBParaSite" id="OFLC_0001388701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001388701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001388701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDP14896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001388701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15237" checksum="8D11EF841A439CEB" modified="2016-09-07" version="1">MIFINECYCSCICRLFKKHKNLAKYYDAEDIDPDSIPKSQKFVLYGMQELQYFFQLPHVYGDDRKWKSALSAFKDHYEELDMPLTEFIKSKDALMATMKKHAGGVSPDQKRNWDALFDKACADMKQWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I373</accession>
    <name>A0A183I373_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14185</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040652">
        <property type="protein sequence ID" value="VDP15824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I373"/>
    <dbReference type="STRING" id="387005.A0A183I373"/>
    <dbReference type="WBParaSite" id="OFLC_0001419301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001419301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001419301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08959">
        <property type="entry name" value="ArfGap_ArfGap1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP15824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001419301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46903" checksum="F302D5AC928E71AE" modified="2016-09-07" version="1">MASPRTRRIIQDIRAVPGNNICFECGASNPQWASVTYGIWLCLDCSGLHRGLGVHISFVRSTTMDKWKDSELNKMKAGGNTKALAFLKSQPDYKSNWSLQERYNSRAAALLRDKVLTESEDREWSIETSPARNYTPNTSLNPSSHSQISGNSSSNSLSTYYGGNATQIGSDSYHSDYDNSGSRYQGFGNVQMNSKDPSNELLSGALSSLSVGWNMLSKGATTAALYAKDIGSQATAKATELSESVRDGTLLNKPGLGGLAQKATEIGSKSWTGISNFIKSPSLQGFVVPGKSDYEDLATPNNQENRFFEQQASNYQTCRIYLEHFRNNSAECGHPKFRITSDPVNYSSSITDSKQSSNKISAMAKREQTPPLIDFSLDDNKMVTNEAMITTRVQEDPIKIIKATINTKNAAPKKDWDDDAWELLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3M7</accession>
    <name>A0A183I3M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14339</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040778">
        <property type="protein sequence ID" value="VDP16608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3M7"/>
    <dbReference type="WBParaSite" id="OFLC_0001434701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001434701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001434701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP16608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001434701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27312" checksum="1632B1201718D1DA" modified="2016-09-07" version="1">GNRKSYHYGAEGHKREKKLKHLEEQNHRDSDNIHSIRFNKVNSGSIQKYESRSSCSGSSRSSQESSVLNTSSYKDKNRSTITDMDNFADIKCHVDDFAKSEQFDVLWHPMLERKNLLADFGNDSNKTKLDGKKCFKNVAVQTVHLEQNCDLLPMFTPLLLKDIEENMKEMNEREVLSTIIQTHVNLIRRQAQREKRMLEEWDSAISDLEERCQFVNFERLKLLLHSNDYFYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I493</accession>
    <name>A0A183I493_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoprotein TPR/MPL1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14555</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040954">
        <property type="protein sequence ID" value="VDP17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I493"/>
    <dbReference type="STRING" id="387005.A0A183I493"/>
    <dbReference type="WBParaSite" id="OFLC_0001456301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001456301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001456301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="3">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001456301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="36008" checksum="03844EBA6D76A3B1" modified="2016-09-07" version="1">MSDDQNSLGTKDQEKEKQQQQSERSGNIGMASGEGKSERQHESMFGKSLPGTSINISNLPDKNIFLEDTLSESVVLPTENVPEHVLFLTNEELDAVRDKLCRVSEAENALKKENEELLRDRSQRMAAMRELEAERDRILLAKNECEQKAEMLLRQREDYEGKINRLNHDKSLILSDLQLQKNEVAKLIEKNVSLDFKLDEYNKQKRVIEFEKERWAQEKEIYLHNKDWFMNEIKERDRKFAVLRIEMVRYTGELQAEIASITDKYESATNDIKKLTATVDDRNKEIRRLNDRVKEVILSKFYICSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4G7</accession>
    <name>A0A183I4G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14629</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041018">
        <property type="protein sequence ID" value="VDP17947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4G7"/>
    <dbReference type="STRING" id="387005.A0A183I4G7"/>
    <dbReference type="WBParaSite" id="OFLC_0001464001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001464001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001464001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP17947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001464001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10663" checksum="94BF4896C7C3F3C8" modified="2016-09-07" version="1">MCAEENAHLVSIHSETENAFVYELASCDRIFIGLRGQTSDRFEWLDGSKVDFKKFFPGFPRGTQYCAYMNGNDMFWYTDSCFTKGCAVCKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4N3</accession>
    <name>A0A183I4N3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041096">
        <property type="protein sequence ID" value="VDP18286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4N3"/>
    <dbReference type="STRING" id="387005.A0A183I4N3"/>
    <dbReference type="WBParaSite" id="OFLC_0001470601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001470601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001470601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP18286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001470601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18058" checksum="C6B92C923F34A086" modified="2016-09-07" version="1">MCYVVLKENVLAKIYYDGAFMLRASTAYRSLLWRLLENLELITLLEHRSSSNLSSEKWPNTILLEASRLASDSRVPKSSSMPARLSVQKPNNKFNDSNHTNSVHFVRSNDTQLLRRSRIPLLSQRPVRTKSGIEAYSNRSSRSSSCEGGETSAGATSPSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I540</accession>
    <name>A0A183I540_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cmyb_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS14852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041280">
        <property type="protein sequence ID" value="VDP19225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I540"/>
    <dbReference type="STRING" id="387005.A0A183I540"/>
    <dbReference type="WBParaSite" id="OFLC_0001486301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001486301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001486301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP19225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001486301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27332" checksum="4CE1057FED26AF8F" modified="2016-09-07" version="1">MENPGYEAFAEHNFWTSNIAQEGNDSCSSQKHSNLESSNNRRRSSFTKHYISTATDDNSVSKRANGQRVKTLANAFMEKENFDYTKRIILKKSSFSSPSQSAFAFSSTSSLSTQCDASSLQSYSAECPADCSFLKRNWFTGPLQHAVPSLHTFKPGRSAKDLITQEEMQKLNPNPKPAVKPKPLTLRRERSDLTSGYVPRIAAYYTKQNNSGTGGDVGVRCALMPPSTCFDENTLLKCLEELKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I664</accession>
    <name>A0A183I664_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15226</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041796">
        <property type="protein sequence ID" value="VDP20920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I664"/>
    <dbReference type="STRING" id="387005.A0A183I664"/>
    <dbReference type="WBParaSite" id="OFLC_0001523701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001523701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001523701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP20920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001523701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12921" checksum="49895A497CC8B725" modified="2016-09-07" version="1">MSKAQAQTSSGKSYNRAHGRYKRGHDNNTDGDDGVSSSRYQRTLTEEEKNDFVNYQKEMDERRDRYERIVKLSRDVIIECKRIIFQLHRTVTVNTSEDKGLIGFNFIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I6G2</accession>
    <name>A0A183I6G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wsv250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15324</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041959">
        <property type="protein sequence ID" value="VDP21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="OFLC_0001533501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001533501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001533501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552785" evidence="3">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP21343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001533501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10180" checksum="70339E4044E426C1" modified="2016-09-07" version="1">MLMMTMTMMMMMVMVMVMIGXXXXXXXXXXXXXXXXXXDDDDDDDDDDGDGDDDRYXXXXMMMMLMMTMTMMMMMVMVMMIGILYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I745</accession>
    <name>A0A183I745_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15557</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042361">
        <property type="protein sequence ID" value="VDP22561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I745"/>
    <dbReference type="WBParaSite" id="OFLC_0001557001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001557001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001557001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP22561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001557001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="48" mass="5647" checksum="15D83911C1BDDB19" modified="2016-09-07" version="1">MIVYDIIGVVGSLQISHDLDDSIEILVMLIHKQLRLMVHRIDWKFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I859</accession>
    <name>A0A183I859_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kringle domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15921</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043256">
        <property type="protein sequence ID" value="VDP24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I859"/>
    <dbReference type="STRING" id="387005.A0A183I859"/>
    <dbReference type="WBParaSite" id="OFLC_0001593401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001593401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001593401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF16">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001593401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="19034" checksum="8B084B3A71F235B4" modified="2016-09-07" version="1">MKLAIVIYYGGEKMEKMITTIYVLENSSYDELHANCTVPQMNCFVHDADHWRTPPFWPERYGQFCFCQNSNNNTYWCLRTVNSTHNFLYCEFITEFISYYDLNTDPYQLHNIIWSIPLGVLEQLSRQLELLRTCQGYAQCEHYSSPAWHLPFTKGDDSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I8D0</accession>
    <name>A0A183I8D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15992</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01043504">
        <property type="protein sequence ID" value="VDP25722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I8D0"/>
    <dbReference type="STRING" id="387005.A0A183I8D0"/>
    <dbReference type="WBParaSite" id="OFLC_0001600501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001600501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001600501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP25722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001600501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19582" checksum="D6D6B588A7F62C17" modified="2016-09-07" version="1">MLVALGVDSRRVYEEEFEEPFLRVSAEYYRAESQNFLLENCASVYVKKVEECLMDESNRAKMYMDKGTEQKILDVLDEELINKHMMTIVEMDNSGVVHMLNNDRIHDLRRLYILLKRVKKGLPTMTDCISRYLRRKGEFLVSENGDREAGTSKNPILYIQVSKYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7V2X7</accession>
    <name>A0A3P7V2X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000662">
        <property type="protein sequence ID" value="VDO29464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H1R0"/>
    <dbReference type="OrthoDB" id="6777468at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="422" mass="47495" checksum="D83FAF2FF97A8A8F" modified="2026-01-28" version="1">MSNRMNAAVQISGLRTPTRSEDASPQQPRRLEVVSKQATKVTAISTRLEWKIDQFEKLMKLFKNGHNLISKQFGCPQAPTVTWELHVYPNGKREEDVGNVSFFLRQVGLQRGEDPIMTEFQIYALDANSLRVSVCRDTKDFTNQQGRGKFQVSRDKMMAALKTDGALLLICEVEYFPPGSKISVEQAVEAEPLDDFDEKNEVSIRDSLKDMLDSELFADCTIKVGNKTLKAHRCILGQHSEVFRSMFAQESMLEAQKGIIDIQDSRFEPVRAMVDYIYTGSTDLVEGYAEDVLAIADKYAILPLKEQCERYLSTTINCKNVASTAVFADTYSASILKQACTKYMSLHHRDVLRSAEWKQMKRERSELANDLLESVLVGDGVANPGEFSFSGSDESSSTSSGNVLMNDNRPPLRKRVRRAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VFN0</accession>
    <name>A0A3P7VFN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001501">
        <property type="protein sequence ID" value="VDO33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10613892at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="98" mass="11355" checksum="EB8580E6E8F04523" modified="2026-01-28" version="1">MTSGCFDFESCYDMMETSSLFVGKADHAKKEIIPETEKDSYNIFHTIKRRHKQLGDAILKTPFNKVMSNYQKTPSLTVSDYFLLNITDIEISLPRRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WM24</accession>
    <name>A0A3P7WM24_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006683">
        <property type="protein sequence ID" value="VDO47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WM24"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="186" mass="20485" checksum="DE4F2823BDB4F4EE" modified="2019-02-13" version="1">MQGGCGSCYALTAAAALEGYYKTKNGKLIDLSPQNIIDCSRKYGNKGCDGGSVHASFEYAKKHGIAQESKYPYVQTEQRCKWKKKIGIVTIEDYVVVKHGDELALKHAVAKHGPVAAAVHSLQPDFKVYKSGIYSSSNCQEPNHAVLIVGYGTHPIAKDYWIVKNKFALIHLLNYLPAYLFCTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XRQ9</accession>
    <name>A0A3P7XRQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009701">
        <property type="protein sequence ID" value="VDO56083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XRQ9"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO56083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="218" mass="24677" checksum="36C3BDB2B5E68799" modified="2019-02-13" version="1">MNNEKFAVRFNEGLKGFEADSWGTEFIFVLPSNSRNINRAACHIFGMNKQENITVNIEYSVSSSEIDNSVVGRKKDNIIFKGHYKFMRYSALPLEVEIKKKMIKLQYDFDNLVVDDTVKGLHMLANNQIHISSSNKISIIAYTIDEKSAADYFLVHPVGMGGDFYAFSLPGPSTVTLYFLPLGATNKTILQSHGVHNVLITARENDKLEIMNQTMQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XSL3</accession>
    <name>A0A3P7XSL3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001249">
        <property type="protein sequence ID" value="VDO32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7XSL3"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058586">
        <property type="entry name" value="Ajm-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038825">
        <property type="entry name" value="Apical_junction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26649">
        <property type="entry name" value="Ajm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="231" mass="26737" checksum="2633CC874271EB50" modified="2019-02-13" version="1">MNCSVHENSPLQNERLYVRCARCHQTRELTEARMQYISCKHCYTYYCSRQCREQDWPKHREVCSFSRINTLCKEVIMKVRKDPEAQFHMSKIARDGYSTLGRGSVNLRMNSAHIAQSYITDGWRAVANSQLNKLLHYYTIAALIAERKEPSLITLCRQYDPTDKFILSVSIMADIEQCPQTPPPEPAVVQRTLPLSQYARQSPLSPQQLTNQENVDFIQSDEFRSAVPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YNB0</accession>
    <name>A0A3P7YNB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017303">
        <property type="protein sequence ID" value="VDO78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO78639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="109" mass="11913" checksum="6FD116DACAF19136" modified="2026-01-28" version="1">MKQQKMKTTYNNLQHKTGSGKVIGLKELSFRNGNKAEHEIRASLSFVTAVEAGTQGSAGDFSDDGKSVTEDKVRSVKGRTVPGIIFFSLRFSPRARRSFSAHFAALSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7YZE8</accession>
    <name>A0A3P7YZE8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS6365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006004">
        <property type="protein sequence ID" value="VDO46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7YZE8"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="257" mass="28833" checksum="84DB75C75384FD86" modified="2019-02-13" version="1">MKLSEDRLSVSGFEGYSVIRATHSVSHGTWYFEVIFTAQPPGSHIRIGWSQAGKFSAPIQACVGYTQLSYAWRSHKGTKFHQAKGKHYADGGFKEGDVLGCLISLPLCPADKEYDFTSVESLPPSSTYLPPSYKNLPLINFKHHYFYEEKDDVSAALKNLRPTFGSWIEFYRNGKSCGIAFKDVYAGFYYPAVSLFQGATVRCNFGPSFRYSVPPGARGMCERVGEMYIEQTLSDVLYLVENEDELAEEAAKCVRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8AXL7</accession>
    <name>A0A3P8AXL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS13977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040510">
        <property type="protein sequence ID" value="VDP15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2L4"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="184" mass="20781" checksum="E652621A51D56234" modified="2026-01-28" version="1">MTEKQEYKFKWDGKEIKHRWEGFVKFGNASAVEMTGKNFDKWLKDGGVIDNKNITTTMTGIAFSKITGSKKKANFNETKEVLVAVAEDRARTTKKDPQEELDVIIEKLSKLEAPSLKGVAKASADGVYNRLTDHTKYTGSHKERFDAEGKGRGKVGREDIVEQTGYVAAYKNKDTYDKIHKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY82</accession>
    <name>A0A183GY82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCHIP-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS192</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000051">
        <property type="protein sequence ID" value="VDO24915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY82"/>
    <dbReference type="WBParaSite" id="OFLC_0000019101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000019101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000019101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO24915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000019101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41299" checksum="6618C46A652B0189" modified="2016-09-07" version="1">MAIPDELQTTDDVIQEDELETMSDATATATDPFNQHDYSINLRMESMRLNADYPMKPERTSLGGCNKNTTKVLTEDIISGVENWQQSECYDQNNLCEKESLRKTHSPVQELLLSDHQTKEMHDVRVELQDDIALGIDESLIQAGKQNKCDFMSHDCDKFNSSFANNSVINNGNDNESSATYNGNNNDNIANNPLTKARNNGPSITLSPDTEIPNDAQYSSLAKQSNDFELISHNNNALATETNDSRDNNDDNSKNILLKNSASEDLMKKSDDIRKISDKLEAFNKNNAMSNVPKKISRPKIEETEMPTKAERQIDRLVYDRISGVVSNLKSLFENNAVHNNNDTCKSASYKLEYGVGRSSGTLNKGVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYB1</accession>
    <name>A0A183GYB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS221</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000061">
        <property type="protein sequence ID" value="VDO25042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYB1"/>
    <dbReference type="STRING" id="387005.A0A183GYB1"/>
    <dbReference type="WBParaSite" id="OFLC_0000022001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000022001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000022001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14073">
        <property type="entry name" value="STKc_NUAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000389">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO25042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000022001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="892" mass="100852" checksum="F000398B539DE985" modified="2016-09-07" version="1">MTIGSSSTGSRNNNRSTKNAKYSTSKVRSNHASGITGGNSMLGGQPLCGLPGGSKSEIKHRFEITKKLGSGTYGKVSLAYDHKTEREVAVKLIKKSAIENKQDLVRIRREIRIMSALKHPNIIQIFEVFENRDKIILVMEYASGGELYDYVSTFGSLPEPEARRIFRQITSAILYCHKHKVAHRDLKLENILLDADNNAKIADFGLSNYFSDKTLLNTFCGSPLYASPEIINGTPYRGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFEPDTPSTASMLIRNMLRVNPERRADIDEIASHWWLNLDENMPVIQELPENQIIDHTPLTDRAETMVVQDLADEADVFMDFGHLSQSTRLKIEEFRRRRKEAEEYIENSPIKPPKARKTDGTELPTLTAAEKSLRYDPKLSREMRERVSVEESDTYYEPLERLKRLESRLQNKDNQATSINKEVRRLKQPSTGTIHGCNGNSSRMKSKNERLSPEQPDDPITSNSKISEISTATNNEISKPSFIPLDSDGMIAATRSHRRQSVETWKLETDSLNILMNQVLEQVEKGPVSMTLVARIKAHPFYDSRPMVKELLESIIAAQPPSVQKEASKLIQQQSQELIKRQTAGIAASKGTTFGITGTRRSSKAYEIAPISPIKVDEKRISGKYQSVGTAQHNGQTKNFGERPWHSVEVGFDPDEDVENDLGTPQSFTHNDELGETTVQDTLFEESSDEEIILNSDRNQIKSNLRDHEEKLKESEECDDEDDDEVEASDSEIDELGEEVEQIENEENGSYHTAISEENLGDLAENIPPPDPHMKIVAPQFVDTFDRGLAKRQSKGKYQHSKVELYGRGVSTECQSPTLPHRRIGGPQPTIERSLFLFDKAFFEFFDSKQKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ60</accession>
    <name>A0A183GZ60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS520</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000179">
        <property type="protein sequence ID" value="VDO26079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ60"/>
    <dbReference type="STRING" id="387005.A0A183GZ60"/>
    <dbReference type="WBParaSite" id="OFLC_0000051901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000051901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000051901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF70">
        <property type="entry name" value="GILT-LIKE PROTEIN C02D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO26079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000051901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21883" checksum="1426987E7C1AE08D" modified="2016-09-07" version="1">PAKLQTAEVAVGNVVNLAVYIEAQCPDTSRFVHRQLLPTWQNMSVTNRISLKIVPFGKAKCFPFDNDYSCECQHGPPECELNQLMNCILEMVSDPHQYVPVISCIQGKRDLHSAGLKCLSKLHISAKRILRCAEGEEGRRLLAKAGIETLHLQPPLNFVPWILINGKRSSDAFYDLKKNLCDALDPVPDECKEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZC1</accession>
    <name>A0A183GZC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS581</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000201">
        <property type="protein sequence ID" value="VDO26296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZC1"/>
    <dbReference type="STRING" id="387005.A0A183GZC1"/>
    <dbReference type="WBParaSite" id="OFLC_0000058001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000058001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000058001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDO26296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000058001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="43590" checksum="1AF436563ED81F42" modified="2016-09-07" version="1">MGKSHKSHLTSSPLHHLWLVKWNFKKLPITLIFWSLLAGSTLIIYYFLLFWSKIPCKSTRISMKVHSFVREVYSLAVRSKIKAGKTDDLKHDEIPKKFPKLEQYVYFFFCPSLVFRQFYPRNSTCNWQIVKNYAYEIILIIYCTDLVFIQLILPRFEKENLTALQFPTIISDIFVSIMAGALCLLLLFYGLLHCWLNMFAEMLRHSDRQFYLNWWSSKSMAEYYRFWNLVVYEWLYVYIYKDISELVGGKKGRFVAQTMVFFFSSFFHEYWFGLALRMFYPVIFTLYFVFGGIFFFISQFITSKRIWNMVMYTNLLIGTGMFVSLYSQEWYARQQCAPYFKNSMLDFFLPRHWFCREFNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZR9</accession>
    <name>A0A183GZR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS729</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000273">
        <property type="protein sequence ID" value="VDO26854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZR9"/>
    <dbReference type="STRING" id="387005.A0A183GZR9"/>
    <dbReference type="WBParaSite" id="OFLC_0000072801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000072801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000072801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19857">
        <property type="entry name" value="DSRM_STAU_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19861">
        <property type="entry name" value="DSRM_STAU_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="457"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="747"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO26854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000072801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="821" mass="92799" checksum="E3106BA04321C876" modified="2016-09-07" version="1">MKGAGVQRVVNGTASEDSLLHPEMWWGLHFTEQEVSPTKYVYNYSQLDENHQRTPMCRIAELARYNKIRHEYKLMDESGPAHKKQFTVSLVLTPNQVFYGKGASIKKAQQSAAESALNGTTLPKPPDKIPSKKVKNDFQNPVVLLRYIAGRLGVEIKFIDEIVPICSTPSHPITRLPMQLVIHYSTANYRPLIRSPFIPMINEQFLVLPPPRVVFGQQRVPTALQPIPVIMRPPNTMISPRFSFFHRYRSQSQFHKIRLILSKDFPEFIGKGITKKRAKSSAANEALSYLGPYLATLEAQSKNKMNGSKDASGLATVEVENIKKDNLKSVITTARNGKPKSSISQIHECALHMRMNVEFLVLKEEGPAHDRHYLLRCKLISAERVFSADGEGSSKKIAKQNACSLMLTKLQSIESSPIFIAAAMLKSQKKIGAPKELKRKTISKDMKMNPEYGHQINPVSRLMQIMQARKQNEPKFQLIAERGQSRYKEFVMEVICDDGLRCEGIGPNKKLAKRAAAEAVLARIGYVKPMPKPGKSLLKKKPEEYVQKSHIDVFELEKERKLVRQRNDEENETENVEKISEVTLSVTASMGSQVMAFADVDRTLYSGEQKGIWGNNTAETKSISDEEKSCTKQHDSQPKRRVTFSNEVSACPPPDDSSYPSALITPLKSEVVVVNKLRKKGRDSKKWLTEIEKKEIAEMAQEFFKYSNIVHPLKIEEKMENDRFDLLDRQMEQLSLNEMSSSSIFSVARHHLESVAEHYKFSVNYTDFPVTPNGIGNQYFSLISIGIDKPIVCHGSGNTEEAAHEDAARNALLLLCKIWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1E7</accession>
    <name>A0A183H1E7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1307</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000593">
        <property type="protein sequence ID" value="VDO29064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1E7"/>
    <dbReference type="WBParaSite" id="OFLC_0000130601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000130601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000130601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552331" evidence="2">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000130601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19946" checksum="F0C905B70CA4010E" modified="2016-09-07" version="1">MYRIDIALFLIPILAINRSYGTSLDIALAFARYAGALFTFEEANFLVIEVMPDVNKPLDNIADALRLSPLAIAMANEFAHNLSRTLMRIAFDLIIFGYLIPLAIIILITVLSCWYIREEIRNLYIMLVPFPVAKKACQAYLERMDKKLIKKLKKQQEEMEKDTVTVTGTPTSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1W3</accession>
    <name>A0A183H1W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS1473</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000699">
        <property type="protein sequence ID" value="VDO29666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1W3"/>
    <dbReference type="WBParaSite" id="OFLC_0000147201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000147201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000147201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000147201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25571" checksum="49310D03DD3C6302" modified="2016-09-07" version="1">MPSPSSPLEYRPTPHLVLIMLFVFFPLIYLCGRLTFTVCSVLVFILKSMFSPVLQLFYENELIPRIAKTQTLEGMMQEVLIEQSSDEQLTDESDEEHELISTVKITDDFIKAQSKSSTNVQTIQSSPLAIQTGLSSIYFQIHHRLYLQKCFKKFCNISEGLHDSEHDSGNDEDHSGLSTTSTATTYTNQTSDISGIRSMQNRDAFKEKMKWRRHGDNAFQINDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2G5</accession>
    <name>A0A183H2G5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="2">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS1675</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01000837">
        <property type="protein sequence ID" value="VDO30399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2G5"/>
    <dbReference type="STRING" id="387005.A0A183H2G5"/>
    <dbReference type="WBParaSite" id="OFLC_0000167401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000167401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000167401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="9">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO30399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000167401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10958" checksum="F1DFD8008DEA54D8" modified="2016-09-07" version="1">MGTCSYVLTGTQQGMNETFATTCHGAGRALSRAKSRRNIDFQEVLNQMQTLGISIRVASPKLVMEEAPESYKSVTDVVNTCHEAGISKKTVKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2U8</accession>
    <name>A0A183H2U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1808</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000924">
        <property type="protein sequence ID" value="VDO30862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2U8"/>
    <dbReference type="STRING" id="387005.A0A183H2U8"/>
    <dbReference type="WBParaSite" id="OFLC_0000180701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000180701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000180701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO30862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000180701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41447" checksum="D19262026218FDA5" modified="2016-09-07" version="1">MIRKLAIHDERILRNVNKNVLDGLVNIDELHICSNFFTKSQYDPLIESLFSFSKLYVLHIQQRYNEDKCHWNIVHERHVKQFASTSLGDIKLQGVVITGSVLKLLCLKYQKTLEKLCLMGALVPSQDASICFQAINSLDRLSYLTLAPSLYSISTTNKAFFKSYPSLKNSKTLKLVAAYVSRPDVSQLKLLLQQIFPVSVEQLILYDESYRSAYQIEQELKKFKCKVQFCRDDDIIIDNYWMNGKSELITHTLWKPPYKTNISLPAMLPEWYCILSELMETALMSEYSCRSSSSTHTARNISQLDECICMNHSASYSDGNQAAPYSLQDKMLEGLSGIAHKHFDLMSEMFTLNMHNVTINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H3N7</accession>
    <name>A0A183H3N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS2097</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001140">
        <property type="protein sequence ID" value="VDO31864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H3N7"/>
    <dbReference type="STRING" id="387005.A0A183H3N7"/>
    <dbReference type="WBParaSite" id="OFLC_0000209601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000209601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000209601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO31864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000209601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24075" checksum="9F1329DD59DFCD0D" modified="2016-09-07" version="1">MKHDVAAVIVEPIQGEGGDNHGSPEFFQGLRDITAKYGVVFIVDEVQTGGGGTGTFWAHDSWNLSSSPDIVVFAKKLMVSGYFYAEHLQMKEPYRIYNTWLGDPTKVILLEKALQVIKRDNLLEQTQRVGKALQSKLRQIESVNNSKIRNVRGLGTFCAFDMPDTATRNKFLEIAGNNGLFIGGCGKVTVRFRPALIFGDEHLEIALDIITKSLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4N2</accession>
    <name>A0A183H4N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2442</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001407">
        <property type="protein sequence ID" value="VDO33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4N2"/>
    <dbReference type="WBParaSite" id="OFLC_0000244101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000244101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000244101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000244101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12555" checksum="264254F09D786569" modified="2016-09-07" version="1">MPPKFQLERAMPMEITANVVLNVKQTPILTQLSHKEEKEEDEHDLFEEECQPEWVTSSFRLGSIRRRKNEKNVAMQRIQKEIELEKQRYSEMMKMRQSDKITLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H4W4</accession>
    <name>A0A183H4W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS2524</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001469">
        <property type="protein sequence ID" value="VDO33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H4W4"/>
    <dbReference type="STRING" id="387005.A0A183H4W4"/>
    <dbReference type="WBParaSite" id="OFLC_0000252301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000252301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000252301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000252301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24392" checksum="481C4073E3F92048" modified="2016-09-07" version="1">MFVLALLEDTVRIKPHQFGESFEPMLMKRLNEQFANKIVPGLGLCIVIYDLIDVGVSYILPGDGSTHTKVKFRFVVFRPFIDEVIEAKVLSSSAEGLMLSVIFFEDIFIPAHRLPQPSIWYWEYQPEDGQSAKLYMDPGKTVRFRIIENIFKDVDPDSSQDELKREKSYQIIGSMAETGLGCVLWWAPNEENANNEEDEGQMEEEMVEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6E7</accession>
    <name>A0A183H6E7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3058</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01001925">
        <property type="protein sequence ID" value="VDO35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6E7"/>
    <dbReference type="STRING" id="387005.A0A183H6E7"/>
    <dbReference type="WBParaSite" id="OFLC_0000305701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000305701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000305701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="9"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000305701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57310" checksum="5D4166E8D7C51EB9" modified="2016-09-07" version="1">MQCGPGIRAVTTTFGVLRGEMISPNVGDLPPVTQYLGVPYGVAPSGQYRFNMAISAAKWTHMPKDAYSLSSVCIQSGIPELAEAKALKTTSAQRYDHMHKLLPKLKPQSEDCLHMNLYVPERMTYHTDLNRKKLPVLVVVHGDEYGWNSGNPYNGTILASYGQIIVITLNYRLGVFGFLGRCESSSCSGNSGLSDLVAALKMLTNILPAFGGDPNLITLLGWGSGASLVSLLMASPITQPNNRLFQRAILLDGSALAPWAMSKNPQPIFFQLAEHLKCVEKMDEKEHLTFNKRSAESIVRCMQDHSPQNITRAARKISTPTFLSRFAPIVDGQVVPNKPEALFGTQYGSLFRNVDLLVGMTSNPAHHLLPNDDIRLGIDKEKRKKIFRTLIRNLYDFHRKEIFAALINEYTDWDNPKDHPKTIRNGVLAALSDVLFVAPLIETARLHSLDDDQKTSNTFMFLFAHESKNMAEEMLATGIQGSISGDHIPYIFGHPLNDDDDVSCNLSFKFTVTSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6F0</accession>
    <name>A0A183H6F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001928">
        <property type="protein sequence ID" value="VDO35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6F0"/>
    <dbReference type="WBParaSite" id="OFLC_0000306001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000306001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000306001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000306001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12758" checksum="FC06B3FD158D9A56" modified="2016-09-07" version="1">MHDCEHIDRVLQLQICFVLNRMNATGIEWLKDIKEKQEISFDPHVLICITIEMCSYCKALKFNGETKGMCCVGEKIKLPQLGEPPQPLKALLAGYTPNQSVSYPKSGNTTCAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6M5</accession>
    <name>A0A183H6M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3137</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002004">
        <property type="protein sequence ID" value="VDO35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6M5"/>
    <dbReference type="WBParaSite" id="OFLC_0000313601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000313601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000313601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000313601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6877" checksum="5D0B5A21A95481BF" modified="2016-09-07" version="1">MYLSVYLSVSSYTCLSNCLKVCLSSMCVSVVETSESNFIGSIHPAILNCTQQFHLQLLRQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7L7</accession>
    <name>A0A183H7L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3479</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002331">
        <property type="protein sequence ID" value="VDO36650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7L7"/>
    <dbReference type="STRING" id="387005.A0A183H7L7"/>
    <dbReference type="WBParaSite" id="OFLC_0000347801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000347801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000347801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO36650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000347801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15572" checksum="113D57EDEF9D1F06" modified="2016-09-07" version="1">MYGVRYNKKLPTLPFPDVDCTNADKGIRSFVKFYTNFILYKFSYEVYMTLVLLSAVVASNIISLLSVIGLVLCLLVDRWRIRRIFLIFVCYHLVVFVYSLLAYIGPIPGECYYGKGILYYPIVRLSNRDITKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7Q5</accession>
    <name>A0A183H7Q5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type phospholipid transporter</fullName>
            <ecNumber evidence="4">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">OFLC_LOCUS3518</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="4"/>
    <dbReference type="EMBL" id="UZAJ01002369">
        <property type="protein sequence ID" value="VDO36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7Q5"/>
    <dbReference type="STRING" id="387005.A0A183H7Q5"/>
    <dbReference type="WBParaSite" id="OFLC_0000351601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000351601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000351601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDO36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000351601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38210" checksum="F5570E214F137622" modified="2016-09-07" version="1">MPFFDCRIKKRCRISASRIIYVNQTSQPEKYRSNAISTTKYNIFSFIPRFLKEQFRRYSNVFFLVIALLQQIPDISPTGRFTTAGPFLIILSVSAIKEIFEDIKRRKSDQTVNNYYAAVLKGHEWKYTFWKDLEVGDIVRVDNDQMFPADMALLSSSEPLGTAYIETSNLDGETNLKIRQGLECTSDLITSAAIKDFQCTIECEHPNQNVNEFTGTLHVHHLRQPLSISQLLLRGARLKHTQWICGVVLYAGHDAKLLMNSKIAPLKQSKIDVIINHRILFLFFMLITLAFISAVGAYLFDHKQLTHAYYLGFQGLFRFFFFFFEITLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8H3</accession>
    <name>A0A183H8H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrocephalus-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3785</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002643">
        <property type="protein sequence ID" value="VDO37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8H3"/>
    <dbReference type="STRING" id="387005.A0A183H8H3"/>
    <dbReference type="WBParaSite" id="OFLC_0000378401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000378401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000378401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="1">
        <location>
            <begin position="70"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000378401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58609" checksum="DBBA61A76BC8C633" modified="2016-09-07" version="1">MDRETSDRMLEELAKLVALRDLQHQLNQHISLPQHGLIIPPIQMTRFPKLEKFAVCPLPDHLATTIIRPKLQSDVFIYSPFQCESVPKVTWVQDCACEVAISVINCLPCELSVSSLALLSEGCAFEPIPMRLILPSSLLLNSIYCINCLRESGRLIITGYSCEILGVRNVCKLRDFPDRVRSKGFLSSMFDIEILPALPVLELKTSLSRAPISEDDIEPTAEITVYSGQTFEHSVSLVNTSETIAIRNVNLVIRQPKVCGGPCMIEIASTEYMKDDNNIIELRRIEPLERKQIKFRIFGIDPSAMAEDGSQKERNSEIEISAYDAPSTEETHDRIPFTGRLLTCEFIFHYRADIDGSNGEQYERKCRLPLAVSIVPAVTVAAWHVLPGDGPTTRYVVVDVTNNTEWDAELTYGKDRVIGVQPKEFCRQINCLVCLLRVPLLCKCCSEVASNAFQEAASRASHMMQMQEMERLRQILERHVSWHLDIRWSISSSNLSGSVPVGPLLSSVSLLKQLVVPVISVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8J2</accession>
    <name>A0A183H8J2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3804</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002664">
        <property type="protein sequence ID" value="VDO37792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8J2"/>
    <dbReference type="STRING" id="387005.A0A183H8J2"/>
    <dbReference type="WBParaSite" id="OFLC_0000380301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000380301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000380301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO37792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000380301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37729" checksum="60126A1C13989959" modified="2016-09-07" version="1">MGVQVCNSRHRLHSVYVRGVDGLSTYQIEKMFAEFDPVAVEMIDEVSCNVIWNDRFAVAKMMLEMTKPLKRIRSRRQVEEGEVADSVEEEEDGEMREEQGDDVTISMVKGSSNKRNTEANVIEVEVDQVEVPPGKWRVITKHVGHKRLIILRFSLREDIAKGRISSTRREISSDSVDPDGYTYKWMNRKNRIRPGLNIFDEKGNELEWDYEHDTRFYEGPGKTADEEDSSPMPTNDKVIIVGTRKHKIRTRGRGAKRFKTVADLLSDSGSLAADREDIRSLKRKSVSGSHGNDSDEDEGDLSDDRDPSPTPQPWDLKKTGVHLRVSAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8T0</accession>
    <name>A0A183H8T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS3892</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002761">
        <property type="protein sequence ID" value="VDO38125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8T0"/>
    <dbReference type="STRING" id="387005.A0A183H8T0"/>
    <dbReference type="WBParaSite" id="OFLC_0000389101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000389101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000389101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO38125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000389101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32322" checksum="3A12543D54C31ECB" modified="2016-09-07" version="1">MSGSTGLTNGQSFRLQSAICTERTSFGSDGSRDKHTGRPKAGREDSELAKVTAKLSPQLSSSVSQAFHLNHHAFQEDVAIDVISDQELISLYEERIPRSSVKYDNVLRKAIFLLREKTRVEEEITGLRARNESLQQLNKTIREKSVRLHAKAEQEEEFISNMLLKRIQKLKNDKEALALKYEQEEEFLTNDLTRKLSQLQNERDELAGQVEAEQSWVVDTLLVKIRKLEAEISANHTALEQLRREKVDLENALEHEQESLFNTLGKRMDQLEAEKRSCFLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9A5</accession>
    <name>A0A183H9A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002948">
        <property type="protein sequence ID" value="VDO38755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9A5"/>
    <dbReference type="WBParaSite" id="OFLC_0000406601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000406601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000406601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000406601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17120" checksum="A2269EFEAB9A6D83" modified="2016-09-07" version="1">MNDKEQSLKHDNRWNISSLFKLNTPPLTFLTSTIHTKSDRYLPETLITNFPHFDRRHKTNPNYHVPPRIESCNHIYIPSAVNHMLIPDRAAKYKFANFMAWREHESAMRLIGTRIKRADYSGRVRYYQIIACGMIPEDLSEPMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H9I5</accession>
    <name>A0A183H9I5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS4148</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003039">
        <property type="protein sequence ID" value="VDO39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H9I5"/>
    <dbReference type="STRING" id="387005.A0A183H9I5"/>
    <dbReference type="WBParaSite" id="OFLC_0000414601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000414601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000414601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000414601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33568" checksum="343FEEEB2BC8709E" modified="2016-09-07" version="1">MPLKSRIDAKRTESERLQAIVVDLLREEENKYCADCEAKQPRWASWNLGVFLCIRCAGIHRNLGVHLTKVKSVNLDSWTPEQVQSMRIMGNKMARRVYEAELPEHFRRPQTDSALESFIRAKYEQKRYILKDWSPPSLDVNDLPLLLDKRQISDRGARSNARERDHCSNSMEKTRNMAGDSNTANITNDSRDGTVTDAPLLDLNTPVVEPFSMMDKKTVDLNNSIMEISESDGMDDFGPIVSAPPAKLGSDIFAVDAVASSSNGKCGTIIGGSENNLEDLASVLGSNPVVNGKCRHNIILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA40</accession>
    <name>A0A183HA40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003263">
        <property type="protein sequence ID" value="VDO39718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA40"/>
    <dbReference type="WBParaSite" id="OFLC_0000435101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000435101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000435101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000435101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21448" checksum="0B500CF115FD7102" modified="2016-09-07" version="1">MNGEEVEKSSLFSPGTDPLIYSIDSLHSNHPPLLFKLLTFTSIIIDDYKGTEKQCSNSFQPADNLPALLFPLTCSVDRGANDYRPVGLKISYDFFQVCRNRPFLSLWIKPRRTKGLSILFFPVLQMQKTKDERKRCYFDFKNCAWYSCITNFKPSKQQFSSELLVPLCMQHIKQVKKSMWYNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAF2</accession>
    <name>A0A183HAF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS4463</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003396">
        <property type="protein sequence ID" value="VDO40083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAF2"/>
    <dbReference type="STRING" id="387005.A0A183HAF2"/>
    <dbReference type="WBParaSite" id="OFLC_0000446301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000446301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000446301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO40083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000446301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38048" checksum="A7FC770D4A606A6B" modified="2016-09-07" version="1">NIILNVIDFIGNIDEKGTEDEGVRTVEKTSGIDLPSNSSEDDWEEEYTTRCYCGLNHNDEFMIQCDMCNVWQHGKCMDIDRRRVPDTYKCEECNPRLLKLSKTQAREMQLKVLARQRKEKEKKHRQRAKGHFKNKIREKSVGLKGIISSNTGKAEEMKKKRIRRNLSKDYIECFKYEYTRSVMAFSRKHVDTGNPSILEALRNDNGVSVMYVTQESMGLVSTRLYHVNEPVIYICGRVSLPHECRGRKEPGTIIPFVILYSDLVVEENKESTPICIDARQFGSKARFARASCRPNIKMQHFFLKGKLHIIGIAAGNIERGDEVVNYDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAV3</accession>
    <name>A0A183HAV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4616</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003594">
        <property type="protein sequence ID" value="VDO40513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAV3"/>
    <dbReference type="STRING" id="387005.A0A183HAV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000461401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000461401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000461401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO40513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000461401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21807" checksum="8DF58B6EBBBDE275" modified="2016-09-07" version="1">MLNDDENGNPKWGRIEQQGTQWREFKYGKTCYPLSFKRNWLLGYIDNNDKHSCDASSEGSDDLPTDLNPIIETKTVTPPSVLDVKLFSLKRRRKGRLSTSDRFPSVMKMSNDALERVSFIVDMENSICSQTWSEIPHLNGAIASLGSIRLPSHYLRTTFRSKHQVRRKLRARRLPRSMSDGEHLGMFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HAW1</accession>
    <name>A0A183HAW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Venom protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003603">
        <property type="protein sequence ID" value="VDO40537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HAW1"/>
    <dbReference type="STRING" id="387005.A0A183HAW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000462201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000462201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000462201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552466" evidence="1">
        <location>
            <begin position="27"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO40537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000462201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="42526" checksum="4D1CCB73E76D8D0F" modified="2016-09-07" version="1">MKVQVLLQTATLTIFVLNVTVSNECAEQLQRCAIITEEYERLMQERKRFAFLNCFTKQICSYELALFENCFERSVRAVRTSFNREILSSDYFIDSANRYLSALENCFDPTQESTQFPDFKPTLIDEDAIYARTIYSVEYADHLWGLPQLTPTYPYLENSATLACLIKERTGRVFGNGINRFIDSTNLKLYVILEKLLLRLEKKIKKIKFTFGKHTYCMQFRNNVNNSCLLEKNEMQCYRRHLSNDKFYQELLIDRDHIIRTCIRNIRLQTRCHSINASRLRACLCSAREEFENRIQTSILQCIQQSHTDHLHRQRQEVQRQWYEQQNKYFSKFILDTGKKQYVLEHAIFLKNERIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBP2</accession>
    <name>A0A183HBP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLOC-1-related complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4904</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003962">
        <property type="protein sequence ID" value="VDO41401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBP2"/>
    <dbReference type="STRING" id="387005.A0A183HBP2"/>
    <dbReference type="WBParaSite" id="OFLC_0000490301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000490301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000490301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO41401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000490301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16567" checksum="51A14BDF21B4A258" modified="2016-09-07" version="1">MERLCNDLQKQGEVVSAQFSEMANSNTNVIMHQMELSRATSSSLLEELNEAHSRTEQFIERNIVRPLSTGATPIRRKQEPLPEPVEIPDANELINKSKENEVPRRLSQYRPRDSILETPFTILSPKALKQTLKCDLDEIVEIPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCN9</accession>
    <name>A0A183HCN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Coiled-coil domain-containing protein 77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">OFLC_LOCUS5252</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004419">
        <property type="protein sequence ID" value="VDO42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCN9"/>
    <dbReference type="STRING" id="387005.A0A183HCN9"/>
    <dbReference type="WBParaSite" id="OFLC_0000525001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000525001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000525001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="141"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDO42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000525001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30044" checksum="548D5A6F42A7AB3B" modified="2016-09-07" version="1">MQNLNLVQLQVCQQDILKVDIAVKNHIEEIRQQKFMTQKEITQCTRDIKDEMAKLAHLIDTLEKFANKINFRNDRIELLAQVKEHRNELERNRQMLRQAILEFVKVMEEQSRNYLLQNGDDPQDIEFRSRRKRAENLKTQTLKATESLSSLVSKMSDQLKLSEDTTSTLIHSSFLLKDTESEYSSMGAHIQSGGKLISKYGRRECTDKILITFALLLYVVKTKTARAELIDSLRENKAENAKRLLQKYDILRSGKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCS0</accession>
    <name>A0A183HCS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS5282</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004461">
        <property type="protein sequence ID" value="VDO42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCS0"/>
    <dbReference type="STRING" id="387005.A0A183HCS0"/>
    <dbReference type="WBParaSite" id="OFLC_0000528101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000528101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000528101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="178"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000528101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53303" checksum="55B2A675932F20AB" modified="2016-09-07" version="1">DDESDENEPRHYALRTHINPVARFCIEPRAPTTRTYTLRRELSSNDLRGSGSRRHIHRKRLFGRSDSDSSSTSSEGAMQANGNARFECHRLRRMNKARAQLRPVNNDDLSYTIGVRELIRRKAGAANISGSDIDPMHIDRSIDFSKIGGLDYHIQSLKEVVLFPLLYGEIFSQFSIQPPKGVLFYGPPGTGKTLVARALANSCSEGDKKVAFFMRKGADILSKWVGESERQLRALFEQAFIMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRCEVVVIGATNRLDAIDPALRRPGRFDRELNFRLPDKNARLEILKIHTSSWGANRPSGNVFKWLSERTSGYCGADLKSLCTEAVLIALRSQFPQIYSSKEKLYIDSKTLKVEKKDFDIAMRRIVPAGRRDFTIPSRILDDRLKILLGHVIDLICRRIPKGYHDIIDSGRELGDIEQILKTVYSNSSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDJ4</accession>
    <name>A0A183HDJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HELICc2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5555</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004838">
        <property type="protein sequence ID" value="VDO43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDJ4"/>
    <dbReference type="STRING" id="387005.A0A183HDJ4"/>
    <dbReference type="WBParaSite" id="OFLC_0000555501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000555501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000555501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000555501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10431" checksum="E45F397F8EB53EE8" modified="2016-09-07" version="1">MQSEFGPRSGVEYYEAKCMHAINQSVGRAIRHRNDYAAIVLIDIRYKNRRIVKDLPSWIQPQLCHATDLDDAILRLENFFSSMNNYIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDV5</accession>
    <name>A0A183HDV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5667</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004992">
        <property type="protein sequence ID" value="VDO43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDV5"/>
    <dbReference type="WBParaSite" id="OFLC_0000566601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000566601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000566601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF90">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000566601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32991" checksum="01F34CC92B300843" modified="2016-09-07" version="1">MKWVLKMYCRILEHRCFMVILFVAVLIYWYFAIIGALRIKTRLDTVKILPRDSPIQKPNRILNDIIWNEYHPVTILINNPLDIRKRQTMQRFWQLVDDFESLPLCKGNISTLLWLRDYEHYYKHGDAISSLWSFFSFGDTESTSKISHSETGLDYDKLESFLESPFYKHWNTCMIVTKTNNGLRVNRFWFIVAYRNTSTWEVRIELMEKWREIADNYKDLNVTVWEANGMFVDQMLSLKTVAIQTGTLTLICMTIVCALFIPNPCSIITASIAIASISLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDW4</accession>
    <name>A0A183HDW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005002">
        <property type="protein sequence ID" value="VDO43924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDW4"/>
    <dbReference type="WBParaSite" id="OFLC_0000567501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000567501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000567501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000567501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3306" checksum="2876A47AB0574A1C" modified="2016-09-07" version="1">MLAGFFEDVSAVARDWKHDPVPFDSIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDW6</accession>
    <name>A0A183HDW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Smg4_UPF3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS5678</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01005009">
        <property type="protein sequence ID" value="VDO43936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDW6"/>
    <dbReference type="STRING" id="387005.A0A183HDW6"/>
    <dbReference type="WBParaSite" id="OFLC_0000567701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000567701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000567701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO43936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000567701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20750" checksum="B5939ABE94A43B7E" modified="2016-09-07" version="1">MKDDSSKLASNATSSKKEKIRRKMPLKIVLRRLPAAMTWEQLETQLNPIPEFEFSEFVAAKSGGGISFSRVYFVFKNDDDIIAFKERFHGYVFVDNEGGESVGIVELAPNPKIPHDKLETAKERDLKCGTIETDHEYKKFLSERENPQKIDPVPLEQLIREIDEKEKMVESNFSLVAFPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HE84</accession>
    <name>A0A183HE84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01005179">
        <property type="protein sequence ID" value="VDO44381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HE84"/>
    <dbReference type="STRING" id="387005.A0A183HE84"/>
    <dbReference type="WBParaSite" id="OFLC_0000579501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000579501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000579501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO44381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000579501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10529" checksum="7E29D1500C441543" modified="2016-09-07" version="1">MSMISIRIVLCNGSTFEQITNGNGNFSDVYYLDNIVGPEKDSLQDLGNDDLFGDLAGMDPIVLSNVDELTSSFESIELRNMESNRMNTNEQPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HFU9</accession>
    <name>A0A183HFU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc knuckle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">OFLC_LOCUS6360</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01006000">
        <property type="protein sequence ID" value="VDO46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HFU9"/>
    <dbReference type="STRING" id="387005.A0A183HFU9"/>
    <dbReference type="WBParaSite" id="OFLC_0000636001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000636001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000636001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF1">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="5">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDO46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000636001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21926" checksum="B123118EA7481CB4" modified="2016-09-07" version="1">MLFCLSSMGEGEETEQIGTCKWFNVLKGYGFITPDKGGDDIFSELNMDGFRSLDAGERVRFVIRKRPEGNEATAVVSAEPGGKLKGSSIRPLGKYKSHVIRCFKCGHYGNHTAAKCKTSVGAEKACYGCHATDHLVADCPQKVNFKNGNKAKKNGSETNNTNAKIENNENLQSETKEEKTDSKMKEITNDKGDISKESNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HHL0</accession>
    <name>A0A183HHL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS6971</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01006974">
        <property type="protein sequence ID" value="VDO48690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HHL0"/>
    <dbReference type="STRING" id="387005.A0A183HHL0"/>
    <dbReference type="WBParaSite" id="OFLC_0000697101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000697101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000697101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO48690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000697101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8666" checksum="2E67347DADCE576D" modified="2016-09-07" version="1">MPPRLIAFDERVFRQRHKYEIKRSMKKNEWILVIKDVQENDVGGYSCQLNTDPVISRTGYLRIKGNLWLNEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HI92</accession>
    <name>A0A183HI92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7204</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007360">
        <property type="protein sequence ID" value="VDO49814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HI92"/>
    <dbReference type="STRING" id="387005.A0A183HI92"/>
    <dbReference type="WBParaSite" id="OFLC_0000720301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000720301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000720301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO49814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000720301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11094" checksum="0446DE550CC0F46D" modified="2016-09-07" version="1">MHKMPITSDNVQVDRIFRPRRAPTFVAIIFLVSAWFANEVALAWAHDRIPRGEMLPLPDLWFSLFPEVRSLLFYENLKYKNDNLIRLLSQSVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HID7</accession>
    <name>A0A183HID7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="5">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS7249</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="5"/>
    <dbReference type="EMBL" id="UZAJ01007432">
        <property type="protein sequence ID" value="VDO50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HID7"/>
    <dbReference type="STRING" id="387005.A0A183HID7"/>
    <dbReference type="WBParaSite" id="OFLC_0000724801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000724801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000724801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000724801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17725" checksum="AA32CBB26B85F4B0" modified="2016-09-07" version="1">MAPSENAENVANDNSKNQCEINGEPFVMKNEPREARCVGRCDMELGDVTHHNVEQLRRLNQAVFPVAYNDKFYKEIVTAGELAKLAYFNDIVVGGVCCRIDTQNGIRRLYIMTLGTLAPYRRLGIGTMLLEHVFVLCDKDPTIDNIYLHVQVFFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HIU0</accession>
    <name>A0A183HIU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7403</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007713">
        <property type="protein sequence ID" value="VDO50834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HIU0"/>
    <dbReference type="WBParaSite" id="OFLC_0000740101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000740101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000740101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO50834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000740101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4065" checksum="3D21295EF15975A9" modified="2016-09-07" version="1">MGIKRKPFNAPTRVFPLHIVFSFSTLMSLSLDLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ37</accession>
    <name>A0A183HJ37_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7498</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UZAJ01007870">
        <property type="protein sequence ID" value="VDO51258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ37"/>
    <dbReference type="STRING" id="387005.A0A183HJ37"/>
    <dbReference type="WBParaSite" id="OFLC_0000749801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000749801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000749801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="7">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO51258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000749801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16064" checksum="EA69E6C437E3D91F" modified="2016-09-07" version="1">MPPASGRPLYGRGLCADELTERNHDIVPSFSTSSQRKAMMDVNQDTYQYGNESFSKDECEKPMPNEEISLLNKILHKKLENLQNGNLEISQARSDPNSPLYSVTSFQSLRLKDELLKALDKMSFYMPSKIQEAALPLLLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJ52</accession>
    <name>A0A183HJ52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7512</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01007894">
        <property type="protein sequence ID" value="VDO51328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJ52"/>
    <dbReference type="STRING" id="387005.A0A183HJ52"/>
    <dbReference type="WBParaSite" id="OFLC_0000751301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000751301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000751301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO51328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000751301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12081" checksum="3B6B93370D2A43B9" modified="2016-09-07" version="1">MIVSVGVVPYVSTYDTQEQARRRGYWIPGLPVKARITEVKRDHKFGLHLINAYLYVIELEHGPFQWTVVKQNKDFAVLAARLLTHRAAERIRGPVRRIMPETSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJS0</accession>
    <name>A0A183HJS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">OFLC_LOCUS7727</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Postsynaptic cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01008250">
        <property type="protein sequence ID" value="VDO52321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJS0"/>
    <dbReference type="STRING" id="387005.A0A183HJS0"/>
    <dbReference type="WBParaSite" id="OFLC_0000773101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000773101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000773101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO52321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000773101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16232" checksum="7CFB10EFA2510E70" modified="2016-09-07" version="1">MIFKFLKFSIETIFIVLKDERNQVLTLNVWVEQSWHDERIRWDPIEFGNISKLTVGKKYLWTPDIVLYNNARDFSRGFVDTNLHILNNGYTQWAPPAKVYSICKLDVRYFPFDDQFCLLEFENSKQNKEMALNGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV3</accession>
    <name>A0A183HJV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7765</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008317">
        <property type="protein sequence ID" value="VDO52434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV3"/>
    <dbReference type="STRING" id="387005.A0A183HJV3"/>
    <dbReference type="WBParaSite" id="OFLC_0000776401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9170" checksum="D31A48DB9C458B60" modified="2016-09-07" version="1">MINYICRVLKKNWKLFRWFTETSESEILEIGDEDWNPPVPESSFCNTEPATGINSTTMQRSLCPWQWKFVFCFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HJV6</accession>
    <name>A0A183HJV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7766</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008318">
        <property type="protein sequence ID" value="VDO52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HJV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000776701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000776701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000776701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000776701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7934" checksum="494CF55E8D052DD2" modified="2016-09-07" version="1">MIRIFDVVEKEGRKEELLCVVSALTAIVRLSGCKYHANNASSGCSSFKQLSGLVMQIMQSSGRPPFKQYPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK14</accession>
    <name>A0A183HK14_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="2 7">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS7830</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="2 7"/>
    <dbReference type="EMBL" id="UZAJ01008424">
        <property type="protein sequence ID" value="VDO52707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK14"/>
    <dbReference type="STRING" id="387005.A0A183HK14"/>
    <dbReference type="WBParaSite" id="OFLC_0000782501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000782501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000782501"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO52707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000782501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14371" checksum="BCD0D6FF35557ECF" modified="2016-09-07" version="1">MKGKTPEEAAKELKDSGMSDEKIRHILPHKVSVQTAVFEGNKPTNSIILPKVTPFTLGTLIALYEHKIFVQGIIWNINSYDQWGVELGKQLAKVIQKEFEVNTQCTTHDCSTNGIINFIKMEKQTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HK70</accession>
    <name>A0A183HK70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS7884</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008534">
        <property type="protein sequence ID" value="VDO52983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HK70"/>
    <dbReference type="STRING" id="387005.A0A183HK70"/>
    <dbReference type="WBParaSite" id="OFLC_0000788101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000788101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000788101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO52983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000788101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10237" checksum="76FC7E270DDF76E9" modified="2016-09-07" version="1">MVSTENTTKWIARKNDDVDGEKMQELPQKKFYRQRAHANPISDHEFDYPVFPEHMFLPILAGPATLCISDPGSLWGSVRFACPAPANLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKD6</accession>
    <name>A0A183HKD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7945</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008641">
        <property type="protein sequence ID" value="VDO53288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKD6"/>
    <dbReference type="STRING" id="387005.A0A183HKD6"/>
    <dbReference type="WBParaSite" id="OFLC_0000794701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000794701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000794701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000794701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16052" checksum="0D71677959EACC1D" modified="2016-09-07" version="1">MTIIVPGEDEFLNYKQLEYSIPFQGYRRWVAFAYIGVNAVGFAANFWVLYTVAPLLFSSTAKVPKSILFYIITLCISDLMIMTVVGTWKFSTVSCVAYLVFEAMNKFVAPVIVVLISRTCYVTVCLDPKSREIAASLKVSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HKI5</accession>
    <name>A0A183HKI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS7997</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01008721">
        <property type="protein sequence ID" value="VDO53558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HKI5"/>
    <dbReference type="STRING" id="387005.A0A183HKI5"/>
    <dbReference type="WBParaSite" id="OFLC_0000799601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000799601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000799601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO53558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000799601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52857" checksum="67B941728A08AC9E" modified="2016-09-07" version="1">GRTVLSDYPSSEKCVGPLSLLFFSRDVEGLPLQEFVNVYNSGWSDLQPELLPFHFSILRDEISGRNAESQLYSSPRGGGLHDRTSSSNEVKPSVSPSAYTGDEYRIYRPLEPLIVPSGAEQKTTDYDISMSSKIKSGRSLPIGIAHPLPKVSEISGSKRHDEISEVRDSKIMPTHSDFDYHRKIREVDYWIGRRSERQSKPCRDLTADIGIDLASDANWEENNAFETHPLESVDKRQSGHDFSAYHGKIGARKIFSTSNLHWTTVSETTSVSYKKRISIERRRPHPISTSHLATYRRQYRPPPPPAEVSAYARHDRAIFESSTLPRTYAGVAIEGDLRTQRVRYEASSLPSTYYSGTETRIQHNPVRYDLPRPSSPPRYEYWTRESNNWTVEGLPRQSCIVDQNGHSVFDDRYVRQTKQEALRYQKSNLEEIPIISLIKDLPMIEDGADECSCATISPATRIKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HLL4</accession>
    <name>A0A183HLL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8374</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009411">
        <property type="protein sequence ID" value="VDO55353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HLL4"/>
    <dbReference type="WBParaSite" id="OFLC_0000837501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000837501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000837501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO55353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000837501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="35" mass="4223" checksum="1DCAA8150B1FADA6" modified="2016-09-07" version="1">MPRRRTNLGYRTRKAEVPLRIIANQTEERRILANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HM29</accession>
    <name>A0A183HM29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS8541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009753">
        <property type="protein sequence ID" value="VDO56181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HM29"/>
    <dbReference type="STRING" id="387005.A0A183HM29"/>
    <dbReference type="WBParaSite" id="OFLC_0000854001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000854001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000854001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO56181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000854001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22559" checksum="BE88DF286278E593" modified="2016-09-07" version="1">MASDDGLNRLEGTSDTKGGLFIRKKTNSNDELFKHPAKSLLGLDVLAKSRARFETNSRKRRAEDGSPGGLSESIHKQIAVYVCEKDKGERRGIYADTRKNECKQRSRHHDKGSREKNRKSQDLRDRSAKTPIFKAPDTPSRSAWEEDDAGQISKRYHSNWDTPTSSGRHDDISSSRSVSSIWRSERNRERQKRNKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HMQ2</accession>
    <name>A0A183HMQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatogenesis-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS8764</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010171">
        <property type="protein sequence ID" value="VDO57285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HMQ2"/>
    <dbReference type="STRING" id="387005.A0A183HMQ2"/>
    <dbReference type="WBParaSite" id="OFLC_0000876301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000876301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000876301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO57285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000876301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26134" checksum="07BAAEDE5E15431F" modified="2016-09-07" version="1">MTDAAELLLNSMKRSMKPKRGVLPLFEKIERMCYNYLKDTFDEQYKGFGPAPKFPNCVYLDFLLCFYCTHANNEAGRNALQMVGETLMAIDRGGIHDHIGKGFHRYSVDSKWHVPHFEKMLYDQAQLLAVYAAYHAITGEFIEVIEDIVSYVDNNLTHKCGGFCSAEDADSLSSFNSVQKSEGAYYVWTEKEIDEILGNKPVNGVQGLTCAEIFKIYYDIKSNGNVPQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HNR5</accession>
    <name>A0A183HNR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS9130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01010883">
        <property type="protein sequence ID" value="VDO58819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HNR5"/>
    <dbReference type="WBParaSite" id="OFLC_0000912601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000912601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000912601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO58819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000912601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11160" checksum="47FF7303615B9725" modified="2016-09-07" version="1">MTNESVFSSSIQNASDDADLQNLNALDSELEDHPRPESLEGTVESKKSEESREEMSKDKKQNMDQKKIKEIEVFDTRQMSVNAAAFTTDLDGSFEVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQ33</accession>
    <name>A0A183HQ33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9596</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01011934">
        <property type="protein sequence ID" value="VDO61767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQ33"/>
    <dbReference type="STRING" id="387005.A0A183HQ33"/>
    <dbReference type="WBParaSite" id="OFLC_0000959401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000959401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000959401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO61767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000959401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17547" checksum="F86C0A449D0B22B6" modified="2016-09-07" version="1">MITIIIKGQLYNEAVDFWSFGVLMYEMLIGQSPFHGEGEDELFDSILNERPYFPKSIGKEAAKCLSAVSYSRNFQLFDRNPNTRLGMPECPDGPIRTHSFFRGVDWKRYEARQIPPPFKPSIVKIKYYFDIFSFFNLNLKYFDIFEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQJ5</accession>
    <name>A0A183HQJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS9763</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012320">
        <property type="protein sequence ID" value="VDO63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQJ5"/>
    <dbReference type="STRING" id="387005.A0A183HQJ5"/>
    <dbReference type="WBParaSite" id="OFLC_0000975601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000975601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000975601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000975601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15913" checksum="2D878ED6411E26E4" modified="2016-09-07" version="1">GRVEFENNERLGLVEILQWKNGSYVNFGIYDGTEAVLRLNPALENWIPPLDSTIVVRERQHVAVLLFVMLSLIALGGVGMAIVFLVINIRFQNHRYIKMSSPNMNNLIIAGSICTYFSVILLGFDTRFVSADTFVALCYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQM1</accession>
    <name>A0A183HQM1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L50, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS9783</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01012359">
        <property type="protein sequence ID" value="VDO63212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQM1"/>
    <dbReference type="STRING" id="387005.A0A183HQM1"/>
    <dbReference type="WBParaSite" id="OFLC_0000978201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000978201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000978201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542">
        <property type="entry name" value="39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO63212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000978201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23923" checksum="FD9A9242B827C602" modified="2016-09-07" version="1">FLKYRYNYQPPNDLENQVKEAIDKLLVDVNDDIRSIDLTKNRRFKFQLLDLLGERLCHIVPNSELHQMKTVGDLIDFYERPFRNLTKYAQMARDNKQTLPKNLHIMEHPFRFHPEDIHAYHGGETAFPGKGGEVFSLRNKRLYRQFKPKKDWFDFEEESFDYTRQDEGMPWDPEIAERMDRYPTKRYNLKTKRFRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HQV2</accession>
    <name>A0A183HQV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator complex subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012564">
        <property type="protein sequence ID" value="VDO64001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HQV2"/>
    <dbReference type="STRING" id="387005.A0A183HQV2"/>
    <dbReference type="WBParaSite" id="OFLC_0000986301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000986301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000986301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO64001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000986301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31097" checksum="89B28F2418932FF2" modified="2016-09-07" version="1">MLSEVLQTVSVQSELQSLHHPHVNGLGGPKHQEILRELIEETLENCEQTFHLICSSWQLESAPPFLDDLFAPLKELQPNTPFRNTHLSLWTAALILISPHNLHNMRCARNLLMEFHKEVILEDWQDSCLQASLQFAIAISYNWLSVHQLVQEVLGGFAIKEDELLEKAIDGLAFQFIRKCVIAMPKFRENFIAFATVDTLIKNFIAHLSNQVFLLQHSGEMELQYVEEMLERGQLHRPRLHFENFIRCIADLYDGDSKYLEQLSTQFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HS68</accession>
    <name>A0A183HS68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intraflagellar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS10332</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01013667">
        <property type="protein sequence ID" value="VDO67664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HS68"/>
    <dbReference type="STRING" id="387005.A0A183HS68"/>
    <dbReference type="WBParaSite" id="OFLC_0001032901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001032901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001032901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO67664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001032901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15336" checksum="233959C696927FD3" modified="2016-09-07" version="1">MSERLAEALTPSKEDISNETDRIKLLELIAECCVQQRNYHFAAKKYTQAGNKLEAMRSLVKSGDTARIVFFATAARNKEIYILAANYLQTLNWKEDGDLMKQIESFYNKANAHEHLASFYEACAQVNYFFFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HT92</accession>
    <name>A0A183HT92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS10704</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014553">
        <property type="protein sequence ID" value="VDO70604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HT92"/>
    <dbReference type="STRING" id="387005.A0A183HT92"/>
    <dbReference type="WBParaSite" id="OFLC_0001070401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001070401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001070401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO70604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001070401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13863" checksum="3AFA47B87B1C61EE" modified="2016-09-07" version="1">MDVDEENTSPFQKEIWQLKHLPYYEEMQKEADDHFRHIKVGLVHAVLLRDIRPGFVHWICELDKYINLYSRRFTKADHIALVKLCYACMTMKGADFRIVKICAQSVSNLLLYVSLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTI7</accession>
    <name>A0A183HTI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS10800</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01014826">
        <property type="protein sequence ID" value="VDO71419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTI7"/>
    <dbReference type="STRING" id="387005.A0A183HTI7"/>
    <dbReference type="WBParaSite" id="OFLC_0001079901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001079901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001079901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="6">
        <location>
            <begin position="37"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO71419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001079901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15650" checksum="6E188A055FFD0DEE" modified="2016-09-07" version="1">MLLFEKYLYQNPLYVEQKQKKNQSISLAAEDAANAVKIAMGANLLDVCFKLYGAFITGSKSLAAEGLHSSLDLTNQIILMYGIRWSKLNPTPTYPYGYGNARYIASLISGCWLFGFGGGVSLYHGITGLLHPHAIESPAWASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HTK4</accession>
    <name>A0A183HTK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS10815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01014861">
        <property type="protein sequence ID" value="VDO71545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HTK4"/>
    <dbReference type="STRING" id="387005.A0A183HTK4"/>
    <dbReference type="WBParaSite" id="OFLC_0001081601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001081601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001081601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO71545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001081601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25205" checksum="F3F2938B89824AB6" modified="2016-09-07" version="1">LLLIFFLAVAGRSPVGIRQPRLPPSPTPLSKYKLSQLPPRYMEPTVPGNSQSSISSTSTVKGTSLREKEQRAKILIDTTNNINLSMSRPESREKQQYSPVLAKPVEVKIARPIIVEKVQRNIRMNERNPSPLYVSSSSHANNKGSTFQDDIFTFDSLKRALEFESKKQQLQPQQQQRQQSKRPTTLATGQRLRQLDFPSSSRATTAQYFGTIDKHEVSNLNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HU09</accession>
    <name>A0A183HU09_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS10961</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01015239">
        <property type="protein sequence ID" value="VDO72713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HU09"/>
    <dbReference type="STRING" id="387005.A0A183HU09"/>
    <dbReference type="WBParaSite" id="OFLC_0001097101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001097101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001097101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDO72713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001097101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17916" checksum="D7E1560E9A319C9A" modified="2016-09-07" version="1">MRKKVADDFKQVQKAEVDAEVDDGFEIIGKKGAGKNERTILVEIDTDDEDDFGIVVDNCHYMPIIDAVLLSPPWGGPSYLKSKLFSLKNMDPKGDKIFRTTRKLTHNIAYYLPRQTDVKELVKLSKDTGGMVEIEQAEVNRKVKAITAYYGELACDASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HUZ4</accession>
    <name>A0A183HUZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-coenzyme M reductase operon protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11306</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016185">
        <property type="protein sequence ID" value="VDO75508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HUZ4"/>
    <dbReference type="STRING" id="387005.A0A183HUZ4"/>
    <dbReference type="WBParaSite" id="OFLC_0001130601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001130601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001130601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001130601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12592" checksum="DF0F3DB80E8EC8DD" modified="2016-09-07" version="1">MSSISMSLRIGNLSNPINHIVENVRAVVENVFQYCPGGLCNIHSVSLQMVTGGPSLPLYIDAGPRNAVKLPMPIKMKDLKAERDKKAVVDELSTLPEGLEVLVYKDGEVKVVDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HV46</accession>
    <name>A0A183HV46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytokin_check_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016320">
        <property type="protein sequence ID" value="VDO75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HV46"/>
    <dbReference type="STRING" id="387005.A0A183HV46"/>
    <dbReference type="WBParaSite" id="OFLC_0001135801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001135801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001135801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001135801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21454" checksum="14804755E4E62C88" modified="2016-09-07" version="1">MTTNAIEITQKMSTETIVLTVSTVEEKKQEENETEGMSYADKILEIVEKLTEQNDNPCTTFIIEEFNDKVTFGKLLSKPEIIDELRKIFHGVKPTNDINITNAIESFHKIPWSSQITNILFVPDEAMYRNRDIYKSDMKSAKDLLKQMAIENPISAPRIVIGNPVYFQDIHSTVSSYSSDTNVDELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HVP1</accession>
    <name>A0A183HVP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01016806">
        <property type="protein sequence ID" value="VDO77324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HVP1"/>
    <dbReference type="WBParaSite" id="OFLC_0001155301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001155301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001155301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO77324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001155301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5817" checksum="1A8403724EB64BFF" modified="2016-09-07" version="1">MPFSSCCKTEKERGIQWNWLGEHTSLRLRWKTRSGQTYALFVAFSEVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HWT4</accession>
    <name>A0A183HWT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS11950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01017919">
        <property type="protein sequence ID" value="VDO80681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HWT4"/>
    <dbReference type="STRING" id="387005.A0A183HWT4"/>
    <dbReference type="WBParaSite" id="OFLC_0001194601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001194601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001194601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF477">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO80681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001194601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11499" checksum="452816CC9DF7BC91" modified="2016-09-07" version="1">MPFCARIQKRILCMHGGISEDLTALVQLDRIERPCEIPDLGILTDLTWSDPSYYVTNYDYNSRRGVARLFGINAVKEFCQILGLDMIVRAHQVIHLLITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HX61</accession>
    <name>A0A183HX61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018246">
        <property type="protein sequence ID" value="VDO81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HX61"/>
    <dbReference type="STRING" id="387005.A0A183HX61"/>
    <dbReference type="WBParaSite" id="OFLC_0001207301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001207301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001207301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552670" evidence="1">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001207301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13863" checksum="865DEDD7A07B1516" modified="2016-09-07" version="1">MVSTQWSWEGARLIALVLNALCGLEEYYHDYYKDLNVVDLFGLRIIEGNLRNIAENVDDHDIHSEIMNEMYNLSLIAGMIANKALPFVANRDREYFIQVINSLLSNNLIKIYFMYANRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXF0</accession>
    <name>A0A183HXF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12163</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018528">
        <property type="protein sequence ID" value="VDO82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXF0"/>
    <dbReference type="STRING" id="387005.A0A183HXF0"/>
    <dbReference type="WBParaSite" id="OFLC_0001216201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001216201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001216201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001216201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="5959" checksum="C26F627CCCF3A156" modified="2016-09-07" version="1">MEYVQINSLECGPGGSSANFETVYEGCSCTGPCTASIGCTCLLYKQVSLTLCYKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXJ8</accession>
    <name>A0A183HXJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12203</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018632">
        <property type="protein sequence ID" value="VDO82774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXJ8"/>
    <dbReference type="STRING" id="387005.A0A183HXJ8"/>
    <dbReference type="WBParaSite" id="OFLC_0001221101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001221101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001221101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO82774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001221101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16183" checksum="51EE484A6EFD441D" modified="2016-09-07" version="1">MYQAASTSCQQKLLLKFPQQTTLVDIWSAGIIFLSLLCRKHPVMRPGDDYEAIAQIAVIFGSEPIEQLARNNNSILLTSWNYPGFDMVKFVNAIRNEEIPRQGKYCYSCRNLFFDNHDGNCMCRISEEHSLMELARGNSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HXL8</accession>
    <name>A0A183HXL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS12229</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01018728">
        <property type="protein sequence ID" value="VDO83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HXL8"/>
    <dbReference type="STRING" id="387005.A0A183HXL8"/>
    <dbReference type="WBParaSite" id="OFLC_0001223101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001223101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001223101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001223101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10435" checksum="46A15E52CBBA974E" modified="2016-09-07" version="1">MTVGDINISKRESQDSPSSEKSSIDEGSSGMEQESDKGAKKRKAGLKLNQIAARLQEKNSPENPSTSDNISDSKYEDLLLSRMKENPVSEMSGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYJ7</accession>
    <name>A0A183HYJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dehydrogenase/reductase SDR family protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS12559</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Putative oxidoreductase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01039867">
        <property type="protein sequence ID" value="VDP11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYJ7"/>
    <dbReference type="STRING" id="387005.A0A183HYJ7"/>
    <dbReference type="WBParaSite" id="OFLC_0001256001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001256001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001256001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001256001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65134" checksum="B2A30698363838AF" modified="2016-09-07" version="1">MDRLYGTVYWDFDRRNGDLLTFVLHGSRSLKSSAERYLQLMRIVYVISMTLIDELLEKGESVISGKDKFLVRKNYSKRSSPNHLSDAIERAITFIIGIQDKPVPVQICVGSTAGWQVFSFYVSDYVLIFQDNRICVHEGKQNNGGCCWVLFDFTSGFFMFHEIGPLTTMIVFVETSITITAVIASQMEQTWQHAADLIAAIKPYIHYIVLPVGLYTASRFLCSLIPGPQHRSKLDLRNRVVLITGASSGLGRELAICFYRRGAKVILTARSIDKLKELCEELKLLPDVTNRNEPVYKYLDISDPNGMAELVSLAVNQRIDVLVNNAGLSMRGSCKDTSMDVHRQVMEVNYFGHVAITKALLDYIPEDGAIVYISSVQGRIAVPFRSSYSASKHAAQAFFDCLRTEERFNTQILVVSVTYMNTGFGRRALTAEGRPMDEDDPNQAKGITPNYAAECIIKALVNRNTELILAPLSHRLAIFLRWFCPTLLFYIMHRRGLKEKSIKNYNGFQFCNSQGYIKFNQSKLRHDIVQLRKDITRMASNRNNISENEISDFLRNNAYLLGSYSAGFLLGYTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYM1</accession>
    <name>A0A183HYM1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS12583</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="UZAJ01039874">
        <property type="protein sequence ID" value="VDP11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYM1"/>
    <dbReference type="STRING" id="387005.A0A183HYM1"/>
    <dbReference type="WBParaSite" id="OFLC_0001258401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001258401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001258401"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057726">
        <property type="entry name" value="Tsg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057635">
        <property type="entry name" value="Tsg_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04668">
        <property type="entry name" value="Tsg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23782">
        <property type="entry name" value="Tsg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552680" description="Glucose-6-phosphate isomerase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Tsg N-terminal" evidence="12">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tsg C-terminal" evidence="11">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDP11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001258401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="701" mass="79199" checksum="46E4E2EC5B7F4D0B" modified="2016-09-07" version="1">MIANIIGWLLPLVLFTLLQDLLQAAMDCNETECGPRVSKCMLLKACNCSINRDNILHNNCSCCNECIQCLDKQYMQCCACVGLCNPHKEASHLNSYVDRFDQDDEDVIVFDKVALVNKVGTTYTFPALREYSFDRRGIFLRCCPNMKVLTRTHRETNCTVVYLDKCMSHKQCSRQCLILGASMLRWFHTGCCECIGHTCLPYGSTTARCKYCTDFDDSLIMIHPYVTRLFGSLQSTEKISGDGGGGIWMAWLLATDHRIPNGMSLHKDPAFLQLQQHFESECKYLKMVDLFKQDPQRFQKYSLTMNTPDGPILFDYSKNIINEETMKKLFNLVNSRNVLNMRQDMFSGKKINFTEGRAVLHIALRNVNNKPLTLDGQNVTSDVNGVLEHMKMFCDQVISGTWKGYTGQAITDVVNIGIGGSDLGPLMVTEALKHYQIGPNVHFVSNIDGTHLAEVLKKIKPETTIFIIASKTFTTQETITNATSAKEWFLSKALNPEAVAKHFVALSTNGPKVREFGIDENNMFGFWDWVGGRYSLWSAIGLSIAVHIGFDNFKKLLQGANAADEHFLNEPVEKNIPIIMALLGVLYINCFKAETHALLPYDQYLHRFAAYFQQGDMESNGKFVMRDGNRVDFPTGPVVWGEPGTNGQHAFYQLLHQGMLCTRLIPCDFIAPVKSLNPIRQNLHHDVSTCSFHCYHNFIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HYU0</accession>
    <name>A0A183HYU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS12652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01039894">
        <property type="protein sequence ID" value="VDP11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HYU0"/>
    <dbReference type="WBParaSite" id="OFLC_0001265301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001265301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001265301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001265301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10251" checksum="EA5387F64F10130B" modified="2016-09-07" version="1">MPPCHGPWLECHHAMVHGKIPCHGPWHGILAPGYQKEASREAMPSGNQTLQFYPSVNDGVKSNRFPLFHISNISPVRICDYSHSTLIMLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I0S4</accession>
    <name>A0A183I0S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13336</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040150">
        <property type="protein sequence ID" value="VDP13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I0S4"/>
    <dbReference type="STRING" id="387005.A0A183I0S4"/>
    <dbReference type="WBParaSite" id="OFLC_0001333701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001333701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001333701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001333701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="9741" checksum="4DB934F06B35DF62" modified="2016-09-07" version="1">MNPNGMLATMNGAAAAAAAAAAAAAHSGSGNGPNGTVTTNGAGTGICGGTAGAGRFSPAVNRGINSTTVAPPTSVVQHQQQQQQAAAAAAVAAAAQAQMPQLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I183</accession>
    <name>A0A183I183_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUC153 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS13495</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040231">
        <property type="protein sequence ID" value="VDP13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I183"/>
    <dbReference type="STRING" id="387005.A0A183I183"/>
    <dbReference type="WBParaSite" id="OFLC_0001349601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001349601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001349601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001349601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10296" checksum="0A56F96A0B6B459A" modified="2016-09-07" version="1">MQFDFHVTKCLLGNTWEIPTVKFTIAKGPSTSPFSLSRHNDDSENSDQFAVSFDDSVYANEFDHVEKVDSRGQNSEQTKRSRFQQFLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I290</accession>
    <name>A0A183I290_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein espinas</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">OFLC_LOCUS13852</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040432">
        <property type="protein sequence ID" value="VDP14815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I290"/>
    <dbReference type="STRING" id="387005.A0A183I290"/>
    <dbReference type="WBParaSite" id="OFLC_0001385301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001385301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001385301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09414">
        <property type="entry name" value="LIM1_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09830">
        <property type="entry name" value="PET_LIMPETin_LIM-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="9">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDP14815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001385301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21693" checksum="5399C026A28C639C" modified="2016-09-07" version="1">MLSTGTSQTTRRTDAPGSTSHGYSWVPPGLTRVKVEEYMAQLPNHVVPRINSSGEKFRERQLMLQLPRQDLSLAYCKHLSNSVERKLYEEFINARNEIALDIGFVCPVLPKQMECKKCRGILERNEMAVIAPKLGENNGWHPACFTCATCEQLLIDLTYCVKDGIIYCERHYAELHKPRCHACDEVSFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I2C9</accession>
    <name>A0A183I2C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin N-terminal SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS13891</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040453">
        <property type="protein sequence ID" value="VDP14925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I2C9"/>
    <dbReference type="WBParaSite" id="OFLC_0001389201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001389201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001389201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001389201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11344" checksum="25F30BE107672EE7" modified="2016-09-07" version="1">MSSLDYEKDPGWQYLRQTREQMAAEQSRPFDSKKNCWIPDAEDGYIAAEITSTKGDNVTVVSARGNEVCLLCKNRRKXXXXEGSRLAVLATDSRADGCCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I335</accession>
    <name>A0A183I335_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">OFLC_LOCUS14147</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040625">
        <property type="protein sequence ID" value="VDP15678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I335"/>
    <dbReference type="STRING" id="387005.A0A183I335"/>
    <dbReference type="WBParaSite" id="OFLC_0001415501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001415501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001415501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002780">
        <property type="entry name" value="Protein CBR-EOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001967">
        <property type="entry name" value="Ras-responsive element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDP15678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001415501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30871" checksum="7A15DB2AE7D018C0" modified="2016-09-07" version="1">MAGEKIDVKTHLAVRAHHCKTCNRSFIEKSHLVRHERIHLEDKPFKCDNCDYSSSRRDKLKEHIQKHHSNSNNGKQHRRRYRRAKQLAQLAAQAKQIQPNMENMFRPIPSSELVDNSSNSLNRSVATNVLPQQNIAEFALSDISRSQNEHRQSQTTDHIEATQQAHPHSFMDFSALNATNSLNIGRPSSATVPATTAMSISPAMSLNFHIGAIMDSPIESLRTPVPRSPHSVSIHSDFFDSSSPAIGPDAQRPMSLPPYSSGGSSTTNNQVGPSWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3F0</accession>
    <name>A0A183I3F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">39S ribosomal protein L55, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040723">
        <property type="protein sequence ID" value="VDP16231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3F0"/>
    <dbReference type="STRING" id="387005.A0A183I3F0"/>
    <dbReference type="WBParaSite" id="OFLC_0001427001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001427001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001427001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.20">
        <property type="entry name" value="Mitochondrial ribosomal protein L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018615">
        <property type="entry name" value="Ribosomal_mL55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044884">
        <property type="entry name" value="Ribosomal_mL55_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09776">
        <property type="entry name" value="Mitoc_L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP16231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001427001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14689" checksum="477F9603463D6757" modified="2016-09-07" version="1">MLKLLRKAAAIRVTSLLSTVKTLYCPDRCNAHHAAISRIKRAKYVRQYYVTLLHPDGSTVQIRAAEPMDLIQMPFNMDTLTDEERRHLEMKRHKIKKFTKKQETVKFNADEYIDLWRKSSKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I3W6</accession>
    <name>A0A183I3W6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED10</name>
        <name evidence="9" type="ORF">OFLC_LOCUS14428</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01040847">
        <property type="protein sequence ID" value="VDP17007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I3W6"/>
    <dbReference type="STRING" id="387005.A0A183I3W6"/>
    <dbReference type="WBParaSite" id="OFLC_0001443601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001443601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001443601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDP17007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001443601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28840" checksum="B38F332BC24149A3" modified="2016-09-07" version="1">MPSIFPECDKLKQVRRAFLGHNILLQAYDSCFSDFFEKFISAEKSADSNPCGYLHGIYRNCIEKNLEKNKIYDIDLNELRKEVLNTTEDLLKDSQTADKYCICPCIADFRIFSIVMKTGIILELKREEMDPSLMGSMSNVPVLQETATDMRYNQLEQTLENFQENARQMGVIASDFTTRSQEPLNQKIHTLISGLHELDHLKNQFMDVKIPLELLEYLDQGKNPQLYTKECLERTLNKNKEVLNFDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I434</accession>
    <name>A0A183I434_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01040903">
        <property type="protein sequence ID" value="VDP17322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I434"/>
    <dbReference type="WBParaSite" id="OFLC_0001450401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001450401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001450401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP17322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001450401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11013" checksum="80C33C95D8D0DADC" modified="2016-09-07" version="1">MFVKCKHMYVLSIQYSSERAISEGTPVRAISSDRSKIILVMVEWKPWKAETKTGKIRFLKGLVGKARLSVIRQHVIDRSYLIPQPYFEEIITDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I4L6</accession>
    <name>A0A183I4L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS14678</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041077">
        <property type="protein sequence ID" value="VDP18190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I4L6"/>
    <dbReference type="STRING" id="387005.A0A183I4L6"/>
    <dbReference type="WBParaSite" id="OFLC_0001468901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001468901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001468901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP18190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001468901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="616" mass="70804" checksum="202D980AB7C20EAA" modified="2016-09-07" version="1">MIELHNVFDLLKQDVSDYLLFIFAAITNGEIGNNCEAINYYKKATELDAEKPLAWQGLYKLYEQGKYVDLEHILIVIQNLLRLPGITPEKVSVYEKELGFILLKLKRFDEAFSNFDRLDVEFCCEALKAMLSTDDWNGDRKKLIEQCLIKIDMGKLDEKIHQKCVKLRCSWAETPEEIQDVLSWHAKYISFDDEWLIDLLRYFVIISYLEQRQVDPSNDAINMLKNAKGKETEFELLLKHIEKMEISSAIKNIDENLKSITCKWPYIGLTLPLLLFQERYEQVLSLLDIVIPQMHPAITKTLNEALFGVRCEALYGIHDDSALMQLNLLLNNNLNNKRLRKDIRLTKYEDPAEEVYWKVMVLKNSQSEESLQEAKSLAANFAKVDSQSWQWLLLHSEICLKLNTEDAFATSALVKAAKLNPYSSKAFFLLGLSLKQKNRAKAIACLERAAKIRPQDAKIVKLLDELLSLEGRNEDLFKHVLQYSKMVPTDLWARKRLALLELQNGNIDAAIGQMQHIVVLDKTDAGIWTTLGDAYKKRGNYQSAIKAYKEAIDLGPDDEIAQIQFIQMCQLTGQLEEAIEQCLKLIEHVESGQNNTNCVYLLYAESILKLAQKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5H9</accession>
    <name>A0A183I5H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS14991</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041457">
        <property type="protein sequence ID" value="VDP19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5H9"/>
    <dbReference type="WBParaSite" id="OFLC_0001500201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001500201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001500201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001500201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11464" checksum="C7FA597B87B7B15A" modified="2016-09-07" version="1">MANVGDAFVILELVVHRLLQRNLLLVVEIVVKVKMAVEIQKRKAITAIWAIVLTVQAVEMLVGKQARMMQHVVVQWLLRMQVSLIRTSRRRKLRMLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5L9</accession>
    <name>A0A183I5L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15031</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041511">
        <property type="protein sequence ID" value="VDP20079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5L9"/>
    <dbReference type="WBParaSite" id="OFLC_0001504201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001504201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001504201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001504201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="10120" checksum="E61C57BBCEA76DB5" modified="2016-09-07" version="1">MCLMRRQTYASIKQIISGTLYQKTMWREQPRLVHQRVRRLLPNPRSRIYWSVCATHYGNAWQRNDRLSARVFSKRFVGPDKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5R6</accession>
    <name>A0A183I5R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbonyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS15079</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01041577">
        <property type="protein sequence ID" value="VDP20284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I5R6"/>
    <dbReference type="STRING" id="387005.A0A183I5R6"/>
    <dbReference type="WBParaSite" id="OFLC_0001508901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001508901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001508901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDP20284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001508901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15318" checksum="FAE4E3A4D1E6C808" modified="2016-09-07" version="1">VTGANKGIGYGIVKGLAEKVYGAVIYLTARNDKLGMESLNKLVKELGNKCHSDIRFHQLDITDRNSCENFASFLKKEHSGLDALINNAGFAFKHSAKESPEEQARVTIGINYEGTKQVSSILFPLIRDGGRLIFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I5U1</accession>
    <name>A0A183I5U1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS15103</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="UZAJ01041617">
        <property type="protein sequence ID" value="VDP20404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183I5U1"/>
    <dbReference type="WBParaSite" id="OFLC_0001511401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001511401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001511401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="237"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDP20404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001511401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36725" checksum="6346CAB0CFFF8310" modified="2016-09-07" version="1">MDLQESGPSVDEEEPPKSLKRKTNEIKKELYSEESGGDDSEEIKSKRTKVDCILGVKKEDNEILAVVRFEDGHHDLIPTRILINKCPKVMSNAIETGAVQVNDVLASGKPKTAKELKKEAAKAAKLAKFYEKVKKAEVKANQTKQPTAEARKREICEYTANTKSGEKKNTVVELPSAYSPKYVEAAWYEWWEQSGFFRPEYKRDLSKQNPKGIFTLVIPPPNVTGTLHLGHXXXXNPKGIFTLVIPPPNVTGTLHLGHALATSVEDAMCRWHRMKGKTVLFNPGCDHAGIATQVVVEKRLKRELGLTRHDLGREKFVEEVWKWKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I620</accession>
    <name>A0A183I620_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15181</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01041727">
        <property type="protein sequence ID" value="VDP20736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I620"/>
    <dbReference type="WBParaSite" id="OFLC_0001519301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001519301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001519301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP20736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001519301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10927" checksum="7CC37BC887F6EC52" modified="2016-09-07" version="1">YVNYENFINFYLIFQQNKISFSILIIGSSIFGQTPSPTVTNSVNFFKPDYQQNETYDTKGGSDIDRLINMLIRNGIQRATPNPDISPNLLQAIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7D7</accession>
    <name>A0A183I7D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS15648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042538">
        <property type="protein sequence ID" value="VDP23042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7D7"/>
    <dbReference type="STRING" id="387005.A0A183I7D7"/>
    <dbReference type="WBParaSite" id="OFLC_0001566201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001566201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001566201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDP23042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001566201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14650" checksum="DC29324F117FBAD0" modified="2016-09-07" version="1">MKSHTNIYQFRCRDCTYATKYCHSLKLHLRKYNHNRATDVTDSAVGIAINATASTSNLCNGSTQAVTENDDTTMRCLSESLAVPSVDCSSPEPLPTTSTMAQEITAALGMTPVVTSNSLNIASHLLFRQQHQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183I7N4</accession>
    <name>A0A183I7N4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypotheticial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01042761">
        <property type="protein sequence ID" value="VDP23594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183I7N4"/>
    <dbReference type="WBParaSite" id="OFLC_0001575901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0001575901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0001575901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP23594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0001575901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11455" checksum="7E1B80941CF1D73C" modified="2016-09-07" version="1">MFVTVNRIAEIVLMNRIVQRYVHVNQTNSNVIMVVVCKKCGSVMVMMIVVIIRMNKLVAIVHHLMVAQQVNLDVVMVDNVFRLVFIVMVPMIVRMDLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7TWR7</accession>
    <name>A0A3P7TWR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000301">
        <property type="protein sequence ID" value="VDO27040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO27040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="113" mass="13161" checksum="677085D9DCCBEA8E" modified="2026-01-28" version="1">MQKSDKRCAESKFLLVIFRKRISLIVEKRKAEVGFAIISSNQNGYWICTLLDDRGQSDGDSEIRFDRRRRIGVELSVRLNGKRYILTVYSTVTFRSVFHQEPSTGCHIKLFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7UQI2</accession>
    <name>A0A3P7UQI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002550">
        <property type="protein sequence ID" value="VDO37400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="86" mass="10284" checksum="D59D1329E20F6B47" modified="2026-01-28" version="1">MHRRIRTHYQICIRIRTCNHICTCTCTCTCIRSPRQQPTRIAVRERFADWKERKVKVTPMTPMQTMRRSANIMRDFLNAISDDQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7US98</accession>
    <name>A0A3P7US98_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor 1-like 2</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">OFLC_LOCUS3807</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. Plays a role in maintaining mitochondrial morphology.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="UZAJ01002667">
        <property type="protein sequence ID" value="VDO37806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7US98"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDO37806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="117" mass="13602" checksum="D879F556B01EBE7B" modified="2019-02-13" version="1">MDLQDVGGQDKIRPLWRHYYTGTQALIFVIDAADRERVDEARQELHRIINDREMRDAIILVFANKQDLSEAMKPHEIQDKLGLTRIRDRNWYVQPSCATTGDGLYEGLTWLSSNCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7VQH6</accession>
    <name>A0A3P7VQH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002341">
        <property type="protein sequence ID" value="VDO36704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="387005.A0A183H7M9"/>
    <dbReference type="OrthoDB" id="10011855at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11468">
        <property type="entry name" value="bHLH_TS_bHLHe22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF104">
        <property type="entry name" value="GH17679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO36704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="94" mass="11007" checksum="327439C9D4953E53" modified="2026-01-28" version="1">MSSTQSTNQATRLSINLRERCRMHDLNEAFDDLRIILPYANDTSVRKLSKIATLLLAKNYILMQASAIEQMRHIIYHLQQQLRNISYTPCDIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7W8W1</accession>
    <name>A0A3P7W8W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS5414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004635">
        <property type="protein sequence ID" value="VDO43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860759at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="69" mass="7539" checksum="AAEACA6C9B171F89" modified="2026-01-28" version="1">MMTSDSTIAHSASGTQLALQLMIEFIVILRPIQACMSGQCCSPPSTLRCRPKQQACPASYPRCHLLCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7WR79</accession>
    <name>A0A3P7WR79_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS7144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007254">
        <property type="protein sequence ID" value="VDO49527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7WR79"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO49527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="128" mass="14987" checksum="FEFADDD77474EAC7" modified="2019-02-13" version="1">MIFGNLILIIVSNFKVIARIEEENERSLRFLHKSSHEKVTKLCQDVMVDAHKERLYAVCHEYIEGECMNDLHNMYRILKPINGGLSVVIREFQNFVKKTGLEALKGMRGDNIPQQFVENVLQDYYMCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7XY57</accession>
    <name>A0A3P7XY57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS2866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001755">
        <property type="protein sequence ID" value="VDO34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826620at2759"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="87" mass="9820" checksum="48A5031672398613" modified="2026-01-28" version="1">MVNNAATQQNTLKMIRINADNPVTNSNEPLKIETFLPIELPTTKPDTNGTHHYSFTIEFEAPKELLLSNKPKFIDLQLEAVLEGQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7Y8T2</accession>
    <name>A0A3P7Y8T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS11025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01015380">
        <property type="protein sequence ID" value="VDO73199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7Y8T2"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO73199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="173" mass="20042" checksum="460403074FAC7E9C" modified="2019-02-13" version="1">MDFIQKFCFLTVLQDDDNSAEQAEAIRERLQICEITSVGINEIVWEASDNEKKTFHELQPINKNEYEFLIPSTSKRVLKRSQDITEERKNEHKRWRTAIDGYAQYSEWINKVNEKVEDMPDLDSAGSVTTTEVTDDPEAEYFIAVDSMRDVINQVGRNSTCNISRINKIDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ZH03</accession>
    <name>A0A3P7ZH03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS7067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01007129">
        <property type="protein sequence ID" value="VDO49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ZH03"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="227" mass="25895" checksum="74E3B1FAEE038C14" modified="2019-02-13" version="1">MNFYQKTSVLDPDYPIQNVYGPYEKLSIRAFFFPIETRLDFSQLNPSILPDLAPKLLVMPEVYAQPSLISSQRTDFVVNYNARATFRYGDTFMIPSTTKTKRVRLHPDTLRGIELRGHHDQNDIGLSALKGVLSVYDNILELNPDMRAKIRNSLVGKLDPEIFAETLTKMNLKYSQDEINGNIRFTFDTLGAVVYIENGGFRTVIRSPNRENRQLLSEAVAVCLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8A4H6</accession>
    <name>A0A3P8A4H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS8499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01009660">
        <property type="protein sequence ID" value="VDO55972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8A4H6"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch helicase C" evidence="1">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="2">
        <location>
            <begin position="192"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO55972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="334" mass="37786" checksum="9FD79D57A28A73B0" modified="2019-02-13" version="1" fragment="single">MIHQAKNLYRFASIVAKRLESLGALTHGDRRATESRDLSQFNLDTRYGRAALDVLLRTITGLLDPPLIPPPKDYKPGNFISDMQCYMEGVGLLSLENGVYTIEKESATIPKFLNRLLGLPVHAQNALFQYFSDIVAELVAQAKHDGTYDMGIMDLGMGGDEARRLETRIFMGRYESGYFRVEIHKIGVERGVSWEDAYAIWKDHHEDQDGFYLASIGNNGKKTAALVYGIGKKRLDTGARLFCITRPSTGRSAKLETIDEITKRFHLATPEEIEQVWKDQFEGSNKTCQHNYFHGRCRNEAMGVYCETGRRTRTYFVLSGSVLSVWPIVEEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8ANZ5</accession>
    <name>A0A3P8ANZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS9696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01012172">
        <property type="protein sequence ID" value="VDO62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8ANZ5"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <sequence length="114" mass="13071" checksum="EBD68D0823EBE17F" modified="2019-02-13" version="1">MLDHKHVTGCLEQLAVIIQNAPDASFSEIVNTRISWQAVVVLLTNQSDERFRDHVFSLLKHILLRADSKMRFNFIKNAGFELLSNQMKGYPVTDEIASSLFSLLFEEAVRFNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P8CZ10</accession>
    <name>A0A3P8CZ10_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS15856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01043066">
        <property type="protein sequence ID" value="VDP24305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P8CZ10"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25478">
        <property type="entry name" value="EGF_Mua-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDP24305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11950" checksum="18349BD7C5CAC747" modified="2019-02-13" version="1">MQCNKNFCRCECPDTHRDLNPANPGRECLSYTGVNECERKEWNECDENARCIDQERLYRCECIKPYVNAAPPGKLPGSVCRLDYCADVNFCPANTTCQNLEGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GXV6</accession>
    <name>A0A183GXV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS66</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000015">
        <property type="protein sequence ID" value="VDO24388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GXV6"/>
    <dbReference type="WBParaSite" id="OFLC_0000006501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000006501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000006501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO24388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000006501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9392" checksum="D3BB4EA360DE8CC9" modified="2016-09-07" version="1">MSPRKKKCQMIRKHYLKMLDKPIICNDSSNYSSTFSQIYFIFQFLLCASNTKQVNLWMCSFINNFVGYFRVLSIIYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GY15</accession>
    <name>A0A183GY15_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS125</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000030">
        <property type="protein sequence ID" value="VDO24641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GY15"/>
    <dbReference type="STRING" id="387005.A0A183GY15"/>
    <dbReference type="WBParaSite" id="OFLC_0000012401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000012401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000012401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="9">
        <location>
            <begin position="447"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="10">
        <location>
            <begin position="574"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO24641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000012401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="690" mass="78189" checksum="F5F8F6AA3D2AB3E7" modified="2016-09-07" version="1">MTRCGIFNKCYFFVLEGRVSIYDLAHTLNVDYEHIENAVSMISKQSSNFILCNAELISRFFVNFFRDYINLLCRDLNERLIDDGIVSISQLAKTWDLPTEILNGLVLVEVGSKVDAIRDGDALYTRSYLSAQRNIIRAMLCGLTKVTPIARLQSELELTNAMFWSLFDELDATKEVPGKIVGARTSNHCLYHPKIYTVLVKQYILRTFLQEGILKLSVFKKLSVAEPKIYMKEVLNNVEHSTLINFPSAIISMKVWNEIEAAVKEEMNSKSFVDIRLHMPEAVQSNADMNQAVTFLMKNSEDWLFVSDTSYIYSRQLHSFAMRSLESLINTRAEEFASSWGKQKIPKKQEKKQDEDWSAAKGKKGKSGKGKVVKQILAEESTPDLLIRISEEELIMELKRTSDIPDELLEDIVEQIRTKAETLLKTRVELLLHNVQTISVQDQKRSHAQLQETLRALYNNICIFEDGAATFEDTVAANLKVYLLRTVCTHFANYVLSYISRTQNIDTLTTKARNETIASIGNTENRTAVEKLFTALLTKNLESFHDAVFGVCSSAICALNLKVPDKKQRVELIKIYEEQLLSQLRECTDPPSGLLLALLILLARNEKIAVHASGKFVSHLIAKVEKHPETSTELAELLTSFQKMVISSMQSKDDVNLIAKLNEKLVALMAAVNGFEYVEKPTVDDVVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GYU0</accession>
    <name>A0A183GYU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tubulin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">OFLC_LOCUS400</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01000128">
        <property type="protein sequence ID" value="VDO25658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GYU0"/>
    <dbReference type="STRING" id="387005.A0A183GYU0"/>
    <dbReference type="WBParaSite" id="OFLC_0000039901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000039901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000039901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552302" evidence="7">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="63"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDO25658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000039901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28279" checksum="B53864D63AA57A93" modified="2016-09-07" version="1">MLLILQKFCNLMILCHGISQLGCECFLDRKIRAKQVPTYTNLNRLIAQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYSPIISASPIVNFLVKKLSTSSYPFRKSPINVLNQVAKWSNATHEMANIWRAVCCIAEMWYQRCPTGFKVGINYQPPTVVPGGDLAKLQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSFDSAEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZ59</accession>
    <name>A0A183GZ59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COPI_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS519</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000178">
        <property type="protein sequence ID" value="VDO26075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZ59"/>
    <dbReference type="STRING" id="387005.A0A183GZ59"/>
    <dbReference type="WBParaSite" id="OFLC_0000051801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000051801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000051801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="3">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO26075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000051801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11905" checksum="A8A61C47BC216813" modified="2016-09-07" version="1">MKQGQILGAYKLARYALEQLSCLKIPYRFEKLIETEALMIRSKPFTDAEELLPMCYRCGISNPLLGTNECIHCKNPFILSFVSFALYHSLMSGLNFLTPPRTAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183GZI2</accession>
    <name>A0A183GZI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000230">
        <property type="protein sequence ID" value="VDO26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183GZI2"/>
    <dbReference type="WBParaSite" id="OFLC_0000064101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000064101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000064101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000064101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14593" checksum="068F130EC61F842D" modified="2016-09-07" version="1">MLRVTLSERLARELQRSVARQEDCVRCLREEKRLHRVRRVYEEDLYLLFWENREYETFIENIESARFSRGDTIGFYKTDSVYTGKRTCRNQDRSDFSVLLNHARSPVFLYSIFINRFSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H1W6</accession>
    <name>A0A183H1W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KTSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS1476</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000701">
        <property type="protein sequence ID" value="VDO29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H1W6"/>
    <dbReference type="WBParaSite" id="OFLC_0000147501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000147501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000147501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000147501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10636" checksum="C04E37A2C2556C06" modified="2016-09-07" version="1">MPWNAANTNQLSVSLFQIIRYGSVTNFWYIEKNKIFYDISYHAVPVNGTAERLKLFINSSNTDSVEILKHITKIGSYYFDLTKYGLRFDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H2Z5</accession>
    <name>A0A183H2Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS1855</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01000963">
        <property type="protein sequence ID" value="VDO31015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H2Z5"/>
    <dbReference type="WBParaSite" id="OFLC_0000185401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000185401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000185401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO31015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000185401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="956" mass="110115" checksum="6071B5C8F5DA7C63" modified="2016-09-07" version="1">MFDCRSPIVVHEVVQSAEKKLNAKLAQSVPSLISSSAATLQHNEILLDKENQKKRMEMSKTVFFVEEGQCDDGWRLVTTRHRRRKSTEASSLLTNNKEENHIRVAVTASPKRTFTNVYERLTNGVLRPPNLSARTSTLSESSGRGLMYPRCAMDLPQTKASMAKVAYCRQLLWKKHQSDLAKKMERRRRQDLQSARKASSVPALSAINFADPDAVSRSAAAFKNRKKVLKKDGIIGIVKERSMPANFERIEELPSENDEDRENIPAGLEDSIVIHSSSDYFTHSRSEPPLSELVLPDGIDADDAWKAMTEEEESLVQEEESLKKEIEEEESISVDDELERQVAAEDVVLEQLEIEHKCEETVDAESCSNKKAPVTWQDVVNNWKRLFLIFFLIFAPFLFIVCLFVCFYSVIVCLIQLAEEMEEYASVSWSEIVEREITRYRKPGEFAERHEKLSSPSRKRNTENATKRHQERQRRAEEIRQMLQKEKAQRLKELSNKVEEVRRKRAELDERKLEHLQMRMAKAEENRQKSIEGIVKKARDDDVKVMEVQFINTIEADNMRHDVMVRNQEWEQRAQTIANERARKNEEKAAKEAAVEERRKIAENQRIEKTREKFEKQELLEAQRNEQEKERSEAARERNKQLNERVAEKKATEAVESEKLMKKIQKKQEETRRRYENTLIQVKHRAVELSSPRPMESVVSLADFSQIPSETPYASTIDNVIGGGTSKKCKLCDIPLDSDFFTMAHFLSASHLSKANIDIGKLTYDCLKTQIDQNVEDVNIEATRQLSLGGESEISKQSTNAKKRRTRLRQKIQARAKEYENLIGESDLAEVYRTPLGKTSIDRSLRDIAKILKTTLGDIVIKDCCNGLVKESFQNKVYTNADLHILERSLSEILRAFRTSDIPQKREMLLKAIVQNDFIDILTVLISCAANGSTFIPSRLQFTIILIIRFCLYSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H382</accession>
    <name>A0A183H382_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Poly(A) polymerase</fullName>
            <ecNumber evidence="12">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">OFLC_LOCUS1942</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="12"/>
    <dbReference type="EMBL" id="UZAJ01001032">
        <property type="protein sequence ID" value="VDO31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H382"/>
    <dbReference type="STRING" id="387005.A0A183H382"/>
    <dbReference type="WBParaSite" id="OFLC_0000194101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000194101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000194101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="227"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="382"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDO31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000194101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56932" checksum="E4C504EE725F63FD" modified="2016-09-07" version="1">MPQEVQQNTTIDAGNNNEKDNKPTTTYLGVSQPISISGPDEFDIVMSAKLDEYLQANGYFETDEEMNLRLKVLSKINAYVKKWVCIVSKRRQMPDCEIQSVGGKLFTFGSYRLNVHTRGADIDSLCVAPRHVDRNDFFTSFYEMLAEDPNTTELRQVQEAFVPVIKLKYYGIEMDILFARLALPRIPEDQQLNDDSILRNLDEKSVRSLNGCRVADEILRLVPNVSSFTYALRAIKLWAKNHGIYSNVLGYLGGVSWAILVARTCQLYPNIGPARLVQKFFLLYTKWEWPHPVVLKETEVSHSRDMPSLQELVWDPRSRSGDRRRFHLMPIVTPAFPQQNSTFNVTKSSLKIIMNEIEEGLITINDIMDGKAEWSTLFEEVNFFTRYKHFLALLCLSATEQDELVWCGLVESKIRFLIANLERRDSIRVCHVHTKYYQPRNDPFPVQISLQNPRCRIWFIGLDLNKTVSRKIDIQHEVQSFMDLLNSMATTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5A8</accession>
    <name>A0A183H5A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2668</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001584">
        <property type="protein sequence ID" value="VDO33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5A8"/>
    <dbReference type="STRING" id="387005.A0A183H5A8"/>
    <dbReference type="WBParaSite" id="OFLC_0000266701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000266701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000266701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000266701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22612" checksum="09CFAE514A902D0F" modified="2016-09-07" version="1">MTTPLSINNQEDYDLFVKNFQGNKEASRNRASRNNAYRPQTQKIQQNQPYFGQQQHHISNQKTLQFNQNSQRQQQQVHPQQLFAARFQAKQPVFSDAIRETVNFGQEVAKLVDEISQYSDVHHKENQDYESVQKLLYIFFNSVSSGQNDNGHTRPLKPLNDGTETGRNRPIAKNLFESDIVLTVDQLKRFEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H5U8</accession>
    <name>A0A183H5U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS2859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001750">
        <property type="protein sequence ID" value="VDO34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H5U8"/>
    <dbReference type="STRING" id="387005.A0A183H5U8"/>
    <dbReference type="WBParaSite" id="OFLC_0000285801-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000285801-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000285801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000285801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17707" checksum="BCB755EE0924FDA6" modified="2016-09-07" version="1">MNDCGKVQVTGEIVQPKYYRINATFISERDPIRNVKVDATSTVYAVVQIGLRGGIFQYTNALKILGKPSQLLTFDEAFFCYRGSTLIDQDKCSKDDFPSNSRPITTPSFPDKPRDVKTSIIIPPSSLSTFSRLFTSTIPTIPSTTDSQTSSSAKKLAVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H626</accession>
    <name>A0A183H626_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kin17_mid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS2937</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01001827">
        <property type="protein sequence ID" value="VDO34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H626"/>
    <dbReference type="WBParaSite" id="OFLC_0000293601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000293601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000293601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000293601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42613" checksum="27425EDF64568681" modified="2016-09-07" version="1">MGKCQYAIDSLPAYTPQLIAFLIALLEFIIVIIAYIARETQRKKTFYGREDFEDIPEEEKMEQEGAIMGKNIEELHIVQSTDRTVEAEVGSVKTPSAKGVKVMVRRKKAISEHTESLEKEATPADAKIIHFTLEIDWTGRGFEFITLLQKALQEVEEFKYIRFKLTDDAQERLCDFLIRKMRTILEESTQRRWLVYGVIHNKIWKVNGLENLLEKGGDIRTQQMLHVTAQGPTEPMTILAYMIEIDVKLEQMKIQSPPIPFNMSSKNRSKMREESPTQSASRTFKKISHMKSKFSSATPKLATPADVTNYFTTMRTMSTLPSEKLPTVTDTFVRSRSSSKDTRHSSTSTKRKSQGRKTEEIRSEKSRNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6N1</accession>
    <name>A0A183H6N1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="14" type="ORF">OFLC_LOCUS3143</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01002009">
        <property type="protein sequence ID" value="VDO35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6N1"/>
    <dbReference type="STRING" id="387005.A0A183H6N1"/>
    <dbReference type="WBParaSite" id="OFLC_0000314201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000314201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000314201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF7">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDO35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000314201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49913" checksum="8E62AE43575C9E2B" modified="2016-09-07" version="1">MLLYYLAAIFKGLHPRVDDDFVDKLNYHYTSAIIFAFAIIVSAKQYVGYPIQCWVPAQFTDAWEQYTENYCWVENTYYLPLTSAFPLEYGDRRARQISYYQWVPFVLALEALMFYIPCIMWRGLLHWHSGINVQSLTQMACDARMMDADARAATVQTIAGHMEDALEIQREVTDVSGMCVSKRWGSYVTCLYVFIKTLYLINVVGQIFLLNTFLGTDNIFYGFHILKDLLNGREWEVSGNFPRVTMCDFEVRVLGNVHHHTVQCVLMINMFNEKIFLFLWFWYFMVSIVSMFSVGHWMLMSFLPGQHMKFIRKYLKATDLATDRQSVKKFVHKFLGYDGVFCMRMISAHAGDIMATELIVALWHNFNDRVRKSPIEMFEGGVTQSPSKLDANFKTWLLGQTRNKPPFDGSNPIRSKKRRKSDGYFTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H6R9</accession>
    <name>A0A183H6R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">OFLC_LOCUS3182</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002051">
        <property type="protein sequence ID" value="VDO35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H6R9"/>
    <dbReference type="STRING" id="387005.A0A183H6R9"/>
    <dbReference type="WBParaSite" id="OFLC_0000318001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000318001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000318001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDO35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000318001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37160" checksum="A0CFCCC40EC05093" modified="2016-09-07" version="1">MSPLLMHAGNSSVPMEPLDDMDETASESNDGTEHTAATTATPGKELVTWLAAQPKLNARSKSGYILFSAEVRKKVMQENPEAGFGEVSKIVGIEWKKLSEEQKKQYEVRAEYIANERAKQEAREPPHMRILPGQIRVYMCKWQTCDFQYDNPEELYDHVKTVHTSQIVIDGENQFVCLWTSCLKYRKDGKPFPSLPRLHRHIKEKHLATSAKSIYPNQRSKNYIPTYVPGSSASSVTPGTTTFVAVQQPTNGPQQVHQTYTIQQAPLTYVTQAVVSTHQIVANGYVNGTAVAVAPTAYLAATPTVVHTNSPHGYHPYQQVRQVNFFFPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H7U4</accession>
    <name>A0A183H7U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS3555</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002413">
        <property type="protein sequence ID" value="VDO36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H7U4"/>
    <dbReference type="STRING" id="387005.A0A183H7U4"/>
    <dbReference type="WBParaSite" id="OFLC_0000355501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000355501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000355501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000355501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15616" checksum="4E5EE74A16DE9301" modified="2016-09-07" version="1">MYKIDAILRRIKSIRLRDPTSKTLLFTSLTMLINPLCGLLVMPMNSGARGLNLTVANHIIFVEPQMDISQIAQAIGRIDRIGQKKQMIVHHFVVYGSIEEQIYYKYSQDQDKDWTVQSIVHLLGLIDNNEEIICDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H866</accession>
    <name>A0A183H866_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein lines</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS3678</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002549">
        <property type="protein sequence ID" value="VDO37397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H866"/>
    <dbReference type="STRING" id="387005.A0A183H866"/>
    <dbReference type="WBParaSite" id="OFLC_0000367701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000367701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000367701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO37397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000367701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="117558" checksum="2B826B686B420718" modified="2016-09-07" version="1">MVFRRAQQSQKEARVVLNTKKLSRLSDIKFRGTIDENEEFFTVRDESFVQMDSLPETMEVTEACDSLFSPSYNCPESSVNDSRDTKSEIFVDSSSEHPVKFTQSIKRLSRQLYRWMSSLDDDGSDILTSARKLVRFSTPLNIERNTEFAKYVSNMSHEICTLAIADSVCKTVLDQYCHWLCTVIFTAVYNELKLKYGIEAEIDKYCSELTINIFKCVYMNAVELLCGQERLHATWSRNDRDVHIALLRASSTNFKKSVSCECIQSLAHLIDQESALYCHSDLDDDSAEEFCYVLLEEDKEKLSQKLISVLQNFAEELWIHILALVLADVVLKNQNSKLQEQFPDINLSSLVQEKIQRRNENSFFSVDDHISLDESSCSMSSDEFINEYTLLDNEKDSLHLYMKQQVDGRISPPLILYEVDSARDIYLNPSLTDVCGTKKQRPVFRSNSGSENSETEWNTRQQYGSEYYNNECFYVEKSTSPAKLNNDGKTGNAEAMKYIEQIIKEAECVISDQAPPKTTQNAKIIDQERNMDLEFDFMMGLQEWSSSTLNAMIHHSTTIFDNEIKLEHHAETDLSKTLKSKDGIHNQEMQKEWKKEIEEGHTSLHSETLLDLTTEITSNYTEDKQIPLKPRCSPDEDKISNISRFMSERAFQDFKDKPIWQSYDSKNGKVKSCNEFDKRHSTEVAPTQVVISEKLIYQDNSIDLFKNDLDIPGPIFRNQKLNLVSAVKSDYTDSIDSDVLDQTYSNFDIVIKKRSNEDEQSFTVEKRKWSKFANEEIGKKLQIQENLRDSKKSETKSDLQFELIMAEITEDKHQETCDLRRVDLENKDAAHRLLHSINEINHEEIKCNDFKNKKEEWKAESYGHPETNQNNDQFKTTILQNLVAVPDGNIAGQKFDPLYSLMISDIDSQACKTDAKKSSSSSTFKPDLTIAGVSRYNTIADNSRQLLIKQKVEDPAEETFGRFQTLKSPEMKLPIEKDLAEVEGIKSNYEKYNMEDNQYPSSVTSGPDSQQESVDIQNMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8B2</accession>
    <name>A0A183H8B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002593">
        <property type="protein sequence ID" value="VDO37560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8B2"/>
    <dbReference type="WBParaSite" id="OFLC_0000372301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000372301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000372301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO37560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000372301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27708" checksum="D1F23FF0DACDA9ED" modified="2016-09-07" version="1">MKKTEKHVKFELPYISKNTSEFYRSQFKKPSLLSEAKILPKINSKYPRILSIPSLQRKAQIDIRSATSYNPSLHIAKLPSSDTTRPKRTTAAIYPTTDKVNCYLTRSRRSAALPVKEVIKSCINYPRISYVDAPISRSTQTNLQLTNWHHAYFHTKTSPIDITRKFCSICPERCRNFVNNNRSMRLSVKNATDNEFDGHLNTQMEMLRSNIPWSKIHPVIRPNSAFSDSVTSRGSQLAWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183H8S5</accession>
    <name>A0A183H8S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS3887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01002756">
        <property type="protein sequence ID" value="VDO38107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183H8S5"/>
    <dbReference type="WBParaSite" id="OFLC_0000388601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000388601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000388601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO38107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000388601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17693" checksum="50A135D3AAE95AC4" modified="2016-09-07" version="1">MESKDSSNESLLEALSTVTCTEKFTDFVPLPAIDYKIMFSVSVAGIGILPGEFAANGALRFHLPVIYIIISRQVRQEETPSVNILGEAKFPNLEWKYVMQMRFRVGTDESTKDRVVDGDLFELGKRHPPIVIRIGDRSIRRVRIEMKFVETLDSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HA95</accession>
    <name>A0A183HA95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS4407</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003329">
        <property type="protein sequence ID" value="VDO39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HA95"/>
    <dbReference type="STRING" id="387005.A0A183HA95"/>
    <dbReference type="WBParaSite" id="OFLC_0000440601-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000440601-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000440601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF28">
        <property type="entry name" value="BUB1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000440601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30422" checksum="F731BB490C5D6684" modified="2016-09-07" version="1">MTDTAEHEWELNRENIRPLRSGRKVKSINDVFAGDKITMIEAEKRFEKDFEKAKVSDNPLDICLHYVIWFEEHFPTGKPSYLFSILTRIINTFGYREEFLNDERMLKFWMKLIENKSDANVDTFFERAYLAGCCRRLAKFYVRWAEIRENSHDINGARTVLKRGRDNCAEPLNLLNEASDALEMRALRNLSDSEGDFIDGSELDMQRLALGQLTGLGPNHEAPVFRNSFKKPYSLHSDIRSHRSESAKKENTFQIYQVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HB91</accession>
    <name>A0A183HB91_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein MAK10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS4752</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01003772">
        <property type="protein sequence ID" value="VDO40946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HB91"/>
    <dbReference type="STRING" id="387005.A0A183HB91"/>
    <dbReference type="WBParaSite" id="OFLC_0000475201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000475201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000475201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="2">
        <location>
            <begin position="3"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO40946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000475201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41342" checksum="C4E050C0545126A8" modified="2016-09-07" version="1">MVLFPSDDNILGRVQLSTVIVDSIRLFAAPPALDSMSQAFSVEQCRECWEEFINDSVKVFLGVIQMFGLNPARQREKIVCCIEDFSTLQAEAERAENAFDLYYFGQESSINLSLTSFVMLHTLYLIKYHFYLSFYLDLFASFEYSYVYWYLNEVVFKWLVNTLDRSITLVAAGEKRMLKVRKKSDRKKMSKCKKEIEMKKKANEKQRFLLFYRAQAKIAEAFFMAAVALIASGKIRMPLSDLEQSRFEHRMSPFSSLSSVTFGISLFVEYTQFIHISRIESLRMLGGAKCFSIAADAFDWARGELESLTGNDEIAQEAAAIARICKNNSVVSRIISSGSKNEVNFVTLWYSLYNIFNLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBW1</accession>
    <name>A0A183HBW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surfactant protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS4973</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004061">
        <property type="protein sequence ID" value="VDO41640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBW1"/>
    <dbReference type="STRING" id="387005.A0A183HBW1"/>
    <dbReference type="WBParaSite" id="OFLC_0000497201-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000497201-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000497201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552478" evidence="2">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO41640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000497201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36584" checksum="773074BD250EB42B" modified="2016-09-07" version="1">MMVKLVIFSALVVLVAAYKEYILKENKTPKEILKAISFNGTCSECKMLISRFAEAIKDPKKVAELEDLLRLLCHETPYEDECRVLVNQLDHFIEKLEPYLVQKNPEEICQHFRLCSNRKIEHFHRINVIYGRKNVDEESAHDLICEECQFAAQELKRTIEDEKTQQRLKRFISEEICSQLGSLRGKCDLLLEEFMPELMEELDKLLQNTKTFCVDIGLCKRSVEPLIVSKNDDINPPKENNSNILRMENDFVKPMNEVTPGNILKSENSLTCKACRDALSKVKARLVDSVFQKVLENILYEKFCQKLPYEKSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HBW9</accession>
    <name>A0A183HBW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">OFLC_LOCUS4978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004065">
        <property type="protein sequence ID" value="VDO41652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HBW9"/>
    <dbReference type="WBParaSite" id="OFLC_0000498001-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000498001-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000498001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDO41652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000498001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10743" checksum="4FC873EC4F7073E1" modified="2016-09-07" version="1">MLIEMANQLQHLSRLLSYAVSVDLLYHVEQMDLLCLKILVGNVWARPTKFRLFRHLTRFRQWTEANILGERYFQQFGKIRRRSRSLSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCE8</accession>
    <name>A0A183HCE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004289">
        <property type="protein sequence ID" value="VDO42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCE8"/>
    <dbReference type="STRING" id="387005.A0A183HCE8"/>
    <dbReference type="WBParaSite" id="OFLC_0000515901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000515901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000515901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000515901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8488" checksum="0CFAB180E3F34D90" modified="2016-09-07" version="1">MSIHYLISGGSCNLCGSQKHLRKDCPLKKGADGNSQRESLVAARNNATGGDDDVLNVESNTESSRAKKMKLERKVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCM2</accession>
    <name>A0A183HCM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosinase_Cu-bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">OFLC_LOCUS5234</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004392">
        <property type="protein sequence ID" value="VDO42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCM2"/>
    <dbReference type="STRING" id="387005.A0A183HCM2"/>
    <dbReference type="WBParaSite" id="OFLC_0000523301-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000523301-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000523301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF84">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044552486" evidence="2">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="156"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDO42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000523301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32993" checksum="F2152392DC17F39E" modified="2016-09-07" version="1">MWFLLLLIPLMFAVEFISGQAQISQEPNRFIRNCDQAPTPAIRSICLNLQRMANNSRRNFEEESRARIQPPGIPEHLRPGMVVPGSRGQVASNPYDCMTLTCLCPYFRGEIDPRNQCVLGNGQVIAMAYRKEYRTLTEVERLRYHSALNVLKRSGEYDRLGRQHQSVAGSGGAHSGPGFLPWHREFIKRFEIALRLIDPSVSVPYWDSILDSYLPDPRDSIFFSTIFMGETDSFGNVITGPFAYWDTLDGRSAIVRSLGREGQLFTEWNIQQVMQQNAIQNILAYTAPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HCY6</accession>
    <name>A0A183HCY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">OFLC_LOCUS5347</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus membrane</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004547">
        <property type="protein sequence ID" value="VDO42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HCY6"/>
    <dbReference type="STRING" id="387005.A0A183HCY6"/>
    <dbReference type="WBParaSite" id="OFLC_0000534701-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000534701-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000534701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000099">
        <property type="entry name" value="Nuclear anchorage protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDO42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000534701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18859" checksum="80666CD2A88103F0" modified="2016-09-07" version="1">MDKSWRDGIAFNALIHRIKPELIDMDIVHRNTPKVNLEQAFRLAKEHLHIRPLLDVEDMLRDKSDKRSVITYVSQFIRTLKHLRPIATCPMIDVHSLISWMEDTLNILRSSIAIPLYDQYQIYLSLRKQYFEHRNAYYSLREHASTLPESEWNQIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD63</accession>
    <name>A0A183HD63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">OFLC_LOCUS5425</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004653">
        <property type="protein sequence ID" value="VDO43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD63"/>
    <dbReference type="STRING" id="387005.A0A183HD63"/>
    <dbReference type="WBParaSite" id="OFLC_0000542401-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000542401-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000542401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDO43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000542401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40361" checksum="92554FF5BDAE9747" modified="2016-09-07" version="1">FQDFRLSLPLITSSSKIHNSSSSFTKPTPPDDVKRKNPRVYSYSPISRTRLTVPKRQFSPEPVRKTAKILIGPRRVTETVHLSDLTKILCKLKAGEFSLPSGFTLKYRKRFADEPKSETMSLNLQDDRDSNDSVQLSFENNVENESKNETSAIFDTAVNAEYAVISEQKEETEISNLPSESKHRRGRKRLNINPTAEKILPANSIVETPIHHTVREESPTPLNIPISKTVKGKPRKRTALIKLKRGKPRKNFIFHATANENTPNSDSSGNVPSSSTLSPSKTSVKDSNRKLASSASKSTVFVTNVPHSLSHGENYGSETDEHEDSKIEVLDSGMSVIFSNKDRAQTGNARKVDDIFDAVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD64</accession>
    <name>A0A183HD64_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5426</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004654">
        <property type="protein sequence ID" value="VDO43101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD64"/>
    <dbReference type="STRING" id="387005.A0A183HD64"/>
    <dbReference type="WBParaSite" id="OFLC_0000542501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000542501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000542501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000542501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36985" checksum="D834A7A41E4252A8" modified="2016-09-07" version="1">MHNWNDVLDYSTASMERALQFEKITSEFFLLVKDCLRKHYKSNSSESYQKYDDRELLLVDDFCKIKTEINMALCDSVDTRTVIEKLRELIGIGNAYINEMEKKNSIPNCLLLRSVASYMTWLLKIFGVVSQNVDIGFPVEQNGTSSHDISNTSKEELLMPYLTALVDFRENVRKVAREQKIIEILEECDRLRDEVLPELGVRLEDRSAQTCVKLVDRETLLREQQQKRVIEAAKEEEKYRKQCEKAAKEASKNIPPWEMFKQGKEAEKFLKYDDKGIPTHLANGEEISKKQRKKLEKLYETQQKNYEQVRFFENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD74</accession>
    <name>A0A183HD74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">OFLC_LOCUS5436</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UZAJ01004667">
        <property type="protein sequence ID" value="VDO43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD74"/>
    <dbReference type="STRING" id="387005.A0A183HD74"/>
    <dbReference type="WBParaSite" id="OFLC_0000543501-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000543501-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000543501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF16">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cuticlin N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDO43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000543501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14398" checksum="20E0514CB5D2BE5E" modified="2016-09-07" version="1">MFANVKVMISFHEEFITKVDRGYEISCFYMEADKTVTYPLTVSMKSLEPFTELAEMPRCHYEVVDPISMEPLSVVSVGSKLLHKWKCDSTATNIVFGRIFLNNSQKINKAGTDTIKSPRVILLLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HD80</accession>
    <name>A0A183HD80_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">OFLC_LOCUS5443</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004685">
        <property type="protein sequence ID" value="VDO43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HD80"/>
    <dbReference type="STRING" id="387005.A0A183HD80"/>
    <dbReference type="WBParaSite" id="OFLC_0000544101-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000544101-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000544101"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044514015" description="Phosphatidylinositol-glycan biosynthesis class X protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDO43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000267606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="OFLC_0000544101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16102" checksum="E7DECD15E1E5F005" modified="2016-09-07" version="1">MIIHIFFSFAVFGLIFCQRCSWINAITTRKASIKFVIPAGAYVDLDSLKDYPLRTHAEAAFDVEASREKSKNTPLYVCSKRGLRKNFVYKEHFELPIHLRYHAATGKDAVVTIPPPQLLLRCMENSTFITSHCKKYLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A183HDE8</accession>
    <name>A0A183HDE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">OFLC_LOCUS5511</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Onchocerca flexuosa</name>
        <dbReference type="NCBI Taxonomy" id="387005"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Spirurina</taxon>
            <taxon>Spiruromorpha</taxon>
            <taxon>Filarioidea</taxon>
            <taxon>Onchocercidae</taxon>
            <taxon>Onchocerca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-06" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UZAJ01004774">
        <property type="protein sequence ID" value="VDO43413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A183HDE8"/>
    <dbReference type="STRING" id="387005.A0A183HDE8"/>
    <dbReference type="WBParaSite" id="OFLC_0000550901-mRNA-1">
        <property type="protein sequence ID" value="OFLC_0000550901-mRNA-1"/>
        <property type="gene ID" value="OFLC_0000550901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000267606">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location
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